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<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0R3WI52_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000017">
        <property type="protein sequence ID" value="VDM16153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI52"/>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16153.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000025401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9001" checksum="955E5241433BA3BA" modified="2016-01-20" version="1">MRASRGRSLPLRSSSRPLTAAVATHALGATSTSHTSPAAAAVPAHTQRQQAGKQAGEGPGRGGRELSHPSTTTVPLLSPAAWSATAPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI83</accession>
    <name>A0A0R3WI83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS294</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000021">
        <property type="protein sequence ID" value="VDM16207.1"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
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            <begin position="179"/>
            <end position="200"/>
        </location>
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        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16207.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000029301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23052" checksum="E05899D92F9D5C60" modified="2016-01-20" version="1">MAQQQQQQNFVKLIVAGVGGVGKSALTLYFMYDEFVKDYEPTRADSYRKKISFGSEDVQLHILDTAGQEDYAGIRDTFYRNSEGFLLVFDLTDRQSFVSLGEFVDQIFRVKRVDRVPMLICGNKVDLTENRRVSKEEAEEFCRKCHVPYLETSAKTNTNVEKAFLSLAQEVYQLKLAQRQQHQPGQPAKQGHKKRRCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI90</accession>
    <name>A0A0R3WI90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OCRE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS302</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDM16215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17780">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="559"/>
        </location>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000030101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="559" mass="62935" checksum="7E25634F1704328B" modified="2016-06-08" version="2"> </sequence>
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<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0R3WIB4_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS332</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000025">
        <property type="protein sequence ID" value="VDM16258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3WIB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000033101-mRNA-1">
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        <property type="gene ID" value="TTAC_0000033101"/>
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    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16258.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000033101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38998" checksum="D1D29105CA3EDBE3" modified="2016-01-20" version="1">MASVKRRAGHLGEEDGRPEKEKISRNTLESDEEISEDEEGGRMDEAELQVGQEPGTIGFDSDIVITPFNMREELEEEGHFDANGTFIFKRVAHFHFQTNDVGDNWLEDVDWNEVRRNEQAGVGDGGVPKTTTMVEEEALPEVTVDQQTELYRRAACLLRSGETVLRALRRLGPKRPAASSNAQRRNWVRRKDGSTGTSIKPLSPTDAANAEAFANLTELANDLLGSGDFDIYQKTKEVIEDLVASRTQRNEDNELNALGAEIDSEAGIEPLDGETAEKQGSVIPTTKWLVKRAKTVEADVQIEGPFEEAVLRQWLESAPSVNIFVKRQDVNEDFRPLSSVDFDKLEALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WID8</accession>
    <name>A0A0R3WID8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS358</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000028">
        <property type="protein sequence ID" value="VDM16302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WID8"/>
    <dbReference type="STRING" id="6205.A0A0R3WID8"/>
    <dbReference type="WBParaSite" id="TTAC_0000035701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000035701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000035701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="53"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM16302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000035701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="44331" checksum="40240BA938F9FFCF" modified="2016-01-20" version="1">MPSPVGIVYSSEVHHLSCLSPKYENRFSLVMGLIFAYGLAKKLLRIPPLELCSSKEMQHLTQFHSEDYVKALQLLDSIYALDDEPNIPDDISEHLDVFGLSYDCSGFRGVYAYALSAVRGTLAAVDSLVDSRCKIAINWAGGWHHAKRSEASGFCYLNDVVLGAQRLLSAPKFSSGPLLYVDLDLHHGDGVEEAFAYTSRVVTFSVHHGACGFFPGSGVPDSSTGDYFKGARGGRFSCFNLPLAEGADDRLWWSSVEPVLTSLYRSINPIAIFVQCGADALSTDPHRIFNLSASLTSNQSAYVSALKLMLSWGLPTLILGGGGYHLPDTARLWLILTAVAISCGTGEQISLNQDIPDHSNLSSFGPDFTIDVSPSMRLNRNSEEAVSQTVERLLRQIDDYCGFNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIF2</accession>
    <name>A0A0R3WIF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS375</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000030">
        <property type="protein sequence ID" value="VDM16323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIF2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIF2"/>
    <dbReference type="WBParaSite" id="TTAC_0000037401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000037401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000037401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00045213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000037401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50477" checksum="BA8F0A1949AED407" modified="2016-01-20" version="1">MTESSPPRLHVVCGSYDGTVFAMSYEHLGIRETGPNRLKAEFIDPEAHSAPVTALAVWNDTVASGSADESIQVGTPYPNIVLALSCSEHFTFARHLCPSCVSQVPFLFSVSRHSRMGCLELHTGSVRHLVFADSRHLLSAGEDACLGIWRRSGGLSRGASAWQCIRQMRRHKAPIISLLLHPSLRLAFTLADGDGDHTFRIWSLTRGRQAYTTRLRALNAEGATALAAVVMPDPPHHYHHLLLLFITPPSSVRYHRIDFIDLGQSRQRALFSARFPTLLSVPPVVFHVEEECLYLLAGIGNVLKVYRCQFGENKMELMSKAKVPGKRFKFLKVLLWPDEMVKAEPEVYGGRRRLVVLVTTDMDGSYVRGYAVDLETTPTSTAEDSSPSMALRPVFTYDVHKIRLTQVDAAWTSGVDGASEEVDHTVSVKDAEGMEISDDDESDSEEEEDDEDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIJ8</accession>
    <name>A0A0R3WIJ8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pleiotropic regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS428</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with CRIPT. Also interacts directly in the complex with BCAS2 and PRPF19. Interacts with USB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000036">
        <property type="protein sequence ID" value="VDM16438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIJ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIJ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000042701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000042701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000042701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000042701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47293" checksum="90636A0799CE3EF2" modified="2016-01-20" version="1">MFEADQVRLPEIDEESYKIKIAVKRRDQYGSTLKKSLGPTLHQKPLQNSLSAAVTSNEIVPIEELDEASDLQSQADTQLVQVGTDKLLLPKKAPTIPKPIWHPPWKLSRVISGHSGWVRCISFDSTNEFFATGAADRMIKIWDFASGYLKLTLTGHISAVRGVVISPRQPYLFSCGEDKTVKCWDLEQNKVIRHYHGHMSAVYDIDLHPTLDVLVTCGRDATARVWDMRTKVNIHTLSGHSNTVSSVRCQESDPQVITASHDATVRLWDLAAGKTMVCLTNHKKSVRSLAIHPTQNAFVSASPDNIKQWKLPNGTFLQNLSGHKALVNALAINMDGVVVSGGDNGSMYFWDWRSGYNFQKLNSVAQPGSINSEAGIFALAFDRSGSRLVTAEADKTIKVYKEDETANEETHPTNWRPGILRKAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIN1</accession>
    <name>A0A0R3WIN1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS468</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000041">
        <property type="protein sequence ID" value="VDM16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIN1"/>
    <dbReference type="STRING" id="6205.A0A0R3WIN1"/>
    <dbReference type="WBParaSite" id="TTAC_0000046701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000046701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000046701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF373">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132836" evidence="1">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000046701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10805" checksum="89165D0C1A1B1B58" modified="2016-01-20" version="1">MSRTFHASLEAVILVLFVISVLNSGYCRGKMSYINRCNLPISSGRCRGYFLRYGYDSETDECRPFVYSGCRGNRNNFFTYNECMNRCFMRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJP9</accession>
    <name>A0A0R3WJP9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS913</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000128">
        <property type="protein sequence ID" value="VDM17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJP9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJP9"/>
    <dbReference type="WBParaSite" id="TTAC_0000091201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000091201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000091201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22976">
        <property type="entry name" value="DD_EFCAB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049760">
        <property type="entry name" value="DD_EFCAB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056587">
        <property type="entry name" value="EF_EFCAB10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24548">
        <property type="entry name" value="EF_EFCAB10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000091201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14307" checksum="6C989550ACF56D26" modified="2016-01-20" version="1">MSNYQNCPKFIEAERYLSEKRIPELLHNLTSLVIFNKPENPLSYMVSILERLKAAQHGRGDNPFIFTLANAESIFYMLDPNMRGYITYEQYKHGLETLGISEFDIMPRGVGQNAITKEVFLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK77</accession>
    <name>A0A0R3WK77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear pore complex protein Nup85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1112</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000187">
        <property type="protein sequence ID" value="VDM17486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK77"/>
    <dbReference type="WBParaSite" id="TTAC_0000111101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000111101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000111101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132895" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000111101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11238" checksum="C0D159FE71AAF0EE" modified="2016-01-20" version="1">MWKWWTLALCDDVAVFVDWVEVLSECAIMIGGVSTDSVEGLSEQTRWFVQARTNLHVLLDSFAHAPSRDMSPELLRYLIRIMQVSDLELLALLVGGGMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKH6</accession>
    <name>A0A0R3WKH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heterogeneous nuclear ribonucleoprotein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1216</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000220">
        <property type="protein sequence ID" value="VDM17639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKH6"/>
    <dbReference type="STRING" id="6205.A0A0R3WKH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000121501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000121501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000121501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22433">
        <property type="entry name" value="KH-I_HNRNPK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000121501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30509" checksum="B17E9B399AB451E8" modified="2016-01-20" version="1">MKRGNGFADDGPPSKYRRSDDPSKLLRVLIPSRAAGPIIGKGGETIKDLRAQYSVRLHIPDSRGPERVFNMEGDRPNICGCLRELTDVLMDVLSAKNADQRLLEGRKDDEGNDLDPAKLLDLRILIHHSQVGSVIGKSGDKIKELREKHRMQIIKIYQEFAPRSTDRVLQLIGEPQNVFACVEDIMETLESAPPRGHRSDYDANNFDADSMPAYDRYMGPPPPPPPPYGYDGPYSGGGPAPPPPPPYGVYDDRAYYDRGYARRGPPPPSSGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKU0</accession>
    <name>A0A0R3WKU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1341</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000269">
        <property type="protein sequence ID" value="VDM17839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000135401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000135401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000135401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000135401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35291" checksum="E046797DA6E090BF" modified="2016-01-20" version="1">MIGDILGQKRSIQRPLSQRDESLEWGMPPFKDLSPMDLCTRLSFPVSPWLPTQQLTADLRFLPQSTLHPDDNILNPGDPFRGLISPDDLALRQRGGMTRHDFGKAVSAPTTVTSVGSGTCQEESGVGKSKKVRKARTAFSDHQLNELERTFERQKYLSVQDRMQLAEKLHLSDMQVKTWYQNRRTKWKRQASVGIELLTEATNNVNRFFQQQQQRTTDDRGNCQRHGLLEPLSALMLRSTPEGVKHPPLPPSDLLELFSTTSTTTTTTPVPSTTSNRALDLDLLKCLPLPPPPPQPPQILPSSLPKPFDHCTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKY2</accession>
    <name>A0A0R3WKY2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000294">
        <property type="protein sequence ID" value="VDM17926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKY2"/>
    <dbReference type="STRING" id="6205.A0A0R3WKY2"/>
    <dbReference type="WBParaSite" id="TTAC_0000140701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000140701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000140701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000140701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="27075" checksum="CF547F25190ADEC6" modified="2016-01-20" version="1">MHTALALTQLSGGNCTHIASPHSPSITIFIIIIPIERAVCASTHASVRACMLGRSASVYATRIVLMEARAHVTEWTSERSGWTAVVAAGGKLPAAALAMNGEGEDLVEQVCKRMKMEKEPEANGDMSVTSIPPACVSSSSSVSSSSSSSSITRSQAAMVCSVNGLVEALKGQQHSGEFAATTTTAATISTATPKVTTAIMMDANSAKNFVSQLLAAAAAGQGRIELGGTGTPTAGTTNAAPLPGEQALDMSVSLPLVCIRWLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL40</accession>
    <name>A0A0R3WL40_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000325">
        <property type="protein sequence ID" value="VDM18043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL40"/>
    <dbReference type="STRING" id="6205.A0A0R3WL40"/>
    <dbReference type="WBParaSite" id="TTAC_0000147401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000147401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000147401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272343at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000147401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="658" mass="73251" checksum="D4400954AC9DA593" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLR4</accession>
    <name>A0A0R3WLR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1689</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000449">
        <property type="protein sequence ID" value="VDM18400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000170201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000170201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000170201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000170201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11677" checksum="281297E4DA108BDF" modified="2016-01-20" version="1">MRGGVGLNSSLLRLEREKEVEVNEDEEEEEEEERGGGKEKGKAGGREGGREIGREMRVLVLISCLTPRQYLLLLLLLLLLLPLPLPLPLPLSLSLPLRLLKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM83</accession>
    <name>A0A0R3WM83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5733 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1858</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000559">
        <property type="protein sequence ID" value="VDM18598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM83"/>
    <dbReference type="WBParaSite" id="TTAC_0000187101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000187101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000187101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043791">
        <property type="entry name" value="DUF5733"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19004">
        <property type="entry name" value="DUF5733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5733" evidence="2">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000187101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42935" checksum="11230D3199DD3B9C" modified="2016-01-20" version="1">MEISRGYAPLFKTHVKGLAKVKIGAQEELSIGEIHQLIASSALKPNDGFLDYKMLLYDDAIRFEKNEDGSSFPEIPFASVLHLVTLPNFPDVCFIQFRRSTYRMYVILRFIKAKYISKVAKFICSWSNANVSDSEESVACTLEPSPPNNDKRLQVKKRTHNQPPVIVHRPNPTGSGPRNQCHRPKAEHTNKILKTEGTQTIIKKSVTNKSTGVGHSIHVHTNHFAPDEEKRVTAIAVKRHHSLPAPIKAEKAPLRKRSSSETSSGETEMAGNVEVNLHWQPGEYTIIVPRHRGWPPSKNARKRKMPKCHAPSHPRGVGRRIPYNTSDSSTSTTSSSSAADMVDMHGREVKTIYPSYMEPGRMSPRSRNNERLLHVLHKPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMN8</accession>
    <name>A0A0R3WMN8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2013</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000684">
        <property type="protein sequence ID" value="VDM18753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMN8"/>
    <dbReference type="WBParaSite" id="TTAC_0000202601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000202601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000202601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132905" evidence="2">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000202601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10164" checksum="21B3637EA0EDBCBC" modified="2016-01-20" version="1">MGAAPFSVLSLIVPLFGTNCVRACVPVLPLPTFPPTYLSLLRPLSFLLSALVQVLLLLLLGMNSSGLDSFIPFLVCVWLGANHCGCALVFGAKSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMS3</accession>
    <name>A0A0R3WMS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exportin-5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2048</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000712">
        <property type="protein sequence ID" value="VDM18788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMS3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000206101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000206101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000206101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000206101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45188" checksum="475A1C1DBD66BE78" modified="2016-01-20" version="1">MPELCVVLLPVLVHNSFITHFASFEFFFSSLETGLSVIQSCDYIFISYLIISGHLIIPYVRLCPAEHINNALIPLMPYVLDALYQKVNKSWAVVKLVNKDEVNGQEVVNEIFVEETVRLLSTSLVEITRTLLLFTGAHPRLPEGMETEEVEVVEGETEQEGEIGATTATSGSMEFGPVAKAFLVDWGTNSIGNHTEMFVRISSWLMAATTWPDSKVCTKAATLLVKVIDYTLSRDGPSVHFNLPTELASQLLIGGLRALQTNGQFLSDVGPPLFSLISRTIAMIEGGFEAVTVHLEPILLSALSSCQGTASDNQHSVEIRKYTELMFNRSKSPSEKVLRERLRNLLKPIIGIPLAEQHNQVLSITALEPLRRPSLRSRQRQRKREGVSVETRVELAIQALADLFEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNF6</accession>
    <name>A0A0R3WNF6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2281</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000923">
        <property type="protein sequence ID" value="VDM19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNF6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNF6"/>
    <dbReference type="WBParaSite" id="TTAC_0000229401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000229401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000229401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="88"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000229401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39488" checksum="DC7AF3085440F9F0" modified="2016-01-20" version="1">DSGESLGVCDSSTPAASTIATEGGSNEDSTNSTSTSRDTNQKEGENEKTVNYVTAKAVREQLVQNTACHLQRTFGSDPEDPSATVLKESWELKAQRIKEASPWGHLPGWQLAAVIVKVGDDLRQEQLAYQLLSYLKEIWANHSIALWLRPLKIVVTSPDSGLIEVVKDTVSLHQIRRHARLSLRDYIIREHGHPNSEGFLSAQRNFVESCAAYSLVGYLLQVKDRHNGNILIDKEGHVVHIDYGFILSASPGRNLGFESSPFKLTAEQVEVMGGVDGDMFNYFKWLIVQGLLTARKHRDEIFDVGRSGALQQRFMLNSTDDQVALSVDHLISQSLNSLSTRLYDNYQYYVNGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNZ2</accession>
    <name>A0A0R3WNZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2467</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001113">
        <property type="protein sequence ID" value="VDM20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000248001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10602655at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31473" checksum="0C9D72871F6F72C5" modified="2016-01-20" version="1">MKTLTFSLLRIRRGDKKDAYCFSSSRKGSSRSCDEEEESAKFSITSLPQSATKPIVLTDVRPLASELRKTPSPVDFNAYAVEQKEIPYSSQPPRTKSFPNFLEEVETCLPKRRISRVNEPLQVEEASRSASDTATAFAQSNIREPTNSVFLQDVCATVPHVVMRKNDALNQTLTRHGFPMPQYGLRSTDSSAWLPIPRSTVQTNMAAAKSDSPHAIVRSRSPSSVHVNEARSSYGRPSASAPSDRHRRLSHPSIRPVKNSTNSRHQPDLKNPITFSEVGSCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPP0</accession>
    <name>A0A0R3WPP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2715</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001424">
        <property type="protein sequence ID" value="VDM20971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000273001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000273001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000273001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270512at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000273001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="60171" checksum="A68E9E724EA9C60F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPR2</accession>
    <name>A0A0R3WPR2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2737</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001451">
        <property type="protein sequence ID" value="VDM21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPR2"/>
    <dbReference type="WBParaSite" id="TTAC_0000275201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000275201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000275201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000275201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13223" checksum="4595F0D06628A6BF" modified="2016-01-20" version="1">MIDKIGYGALRSQNLYLPGAVTAAFAAYLTWSAVMSQPKSVIRGLSVEKQAIQFFNLRLHSNRSASHRLALNQTGLLMDNICLPAILHRPSALDHISDLFAALGIIFVVGGSIYSRFEAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPR7</accession>
    <name>A0A0R3WPR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001458">
        <property type="protein sequence ID" value="VDM21053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPR7"/>
    <dbReference type="STRING" id="6205.A0A0R3WPR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000275701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000275701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000275701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287258at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000275701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28590" checksum="9ECC673BD72CC8D4" modified="2016-01-20" version="1">MRDKAKLSWKEARQEAETCSLVVPTADGDSVEEVVKTPVWMTAIDDSNGGLIMSTNNLSETPHPPLDAHRRWVAQTANSLPSNVRSKPSNTPPSKSISDPSVVDGPRLSSQKTDSLSRKRPMESPQLRPRLTSRLGESFAPNRDLNEAQPTTQAPSPPAHQQPAMASVNGMGQTNVHLHNAYYPMGPQQSPTTTKGWSQRRRPPHVLLSTGAKPVVSTTPGVIASPLQPGASLTRPPLKRDLLISDSRKVEESGSSSSGKCCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQQ4</accession>
    <name>A0A0R3WQQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3079</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001893">
        <property type="protein sequence ID" value="VDM21914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQQ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQQ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000309401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000309401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000309401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000309401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39874" checksum="A6307F81292F5D9C" modified="2016-01-20" version="1">SSSHSTTIIASRIPPNDHDQPKQTSVTRGKPEWQKNTLRVCGNWSEQLSSKGKVYFYNCITEVSQWQKPLEWTLPDMTQSQTVKRSYSTLSQVERVQSRLQDGASSPKRQRYTGSKGGSDRTKVEGSSYSHIEQHNLHLVSPRKVDHSGKAAVYSFKLEFSRDVGHGSPQRVSGNVRDSFEGVKTSSSLASSTHNAISLENHASCEGDADLQSKVPSGRVPAHDDQAHAIMPPKLATILASHSTRSPLLVASSSVQVPSGDPQPSISRSSSPSLPRGEAALTLRQHSANACQRRFPHDLPVVNNGGPLLPDTLPRDSCSSKSDRRSAQIDKQSADDALYHPLWVPCVDSGGVCLAEHIRQAFSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR51</accession>
    <name>A0A0R3WR51_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3226</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002092">
        <property type="protein sequence ID" value="VDM22191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR51"/>
    <dbReference type="STRING" id="6205.A0A0R3WR51"/>
    <dbReference type="WBParaSite" id="TTAC_0000324101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000324101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000324101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000324101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36634" checksum="D39A78E5CAA24808" modified="2016-01-20" version="1">MINGRSNSTSNDGNSSSHNEFVVNQEWKLIKRIGSGSFGEIFLAVNKKTKVEAAAKLELIRSGLPIQLKTEYDLLKLLNNASGITKLYWFGRDGVQNLYTALVMELLGPSLEDLHVYCDLKFSLKTVAMLADQMIKRVETVHKCGLVHRDLKPDNFAMGTGQNMNTVYIIDFGLSKFYIDPNTQEHYPFRDFRSLTGTARYCSINAHAGCEQSRRDDLESLGYVLVYLTKGHLPWQGLQAESKREKFRKIYKTKQTVKAEILCEGLPEEFLKYINYCRSLAYEEEPKYRYLRSLFWKIMDKNGYKYDAQYDWITPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR71</accession>
    <name>A0A0R3WR71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002120">
        <property type="protein sequence ID" value="VDM22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR71"/>
    <dbReference type="STRING" id="6205.A0A0R3WR71"/>
    <dbReference type="WBParaSite" id="TTAC_0000326101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000326101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000326101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000326101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16354" checksum="4A8DBED9901C1306" modified="2016-01-20" version="1">MKGVDVVSKTAEGSRKLLCGAIEGDVVYSGLERHFELRDLQPASRIAFRVRAINSAGAGGWSPVGGCVMPAARPDQPSGLALDSSSVSTTSITGAVSESEVSVGGVSMTTARLVWTAPFDNGCPITCKRFLIAYHSLVTFFYFTSEGVNEDFLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRQ6</accession>
    <name>A0A0R3WRQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002426">
        <property type="protein sequence ID" value="VDM22616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRQ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000344601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000344601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000344601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279890at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000344601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13688" checksum="87F272937F85BAC3" modified="2016-01-20" version="1">METNFLFHKYDKDGDNMLDFVECRRMREEMSLGIAFQPADSDDEDSHFEDHEKSQQGSDKNLFAELEDCEELFERIADVERNVNTAVKQICFILGKLQSAERHRREDEHTLMKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRT6</accession>
    <name>A0A0R3WRT6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3461</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002467">
        <property type="protein sequence ID" value="VDM22678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRT6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRT6"/>
    <dbReference type="WBParaSite" id="TTAC_0000347601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000347601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000347601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273039at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000347601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26408" checksum="1CE8548106A98EB8" modified="2016-01-20" version="1">MQPTGKVKYYVKCFTPEPYHLVSTLHIRDVDPSDVGRYECFVDNGIGSPVVRLIDLIYPFAPRVLEIGRWSRAAPPHDPPETAFNHTHLMPLDPMPPTAVVCIVAAEPAPTVVWFREPANLTLVEGGQFKSSITRLHAGRYRALLTIEFVRQVDFGSYYCQAKNDIGMDVGKVILGPTTSPDRPGNPVLMKATSSSLTVGWQQAFNGGPPQTFIVSKMDSSVLRFHSIKSSVVLNCLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS55</accession>
    <name>A0A0R3WS55_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRKCSH-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3580</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002671">
        <property type="protein sequence ID" value="VDM22913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS55"/>
    <dbReference type="STRING" id="6205.A0A0R3WS55"/>
    <dbReference type="WBParaSite" id="TTAC_0000359501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000359501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000359501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosidase II beta subunit N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000359501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33428" checksum="E7F0BBF903B7C622" modified="2016-01-20" version="1">MTSPLLIVSSPVGSLAPAMGRQTFSIWIFLLAMLRASEVPTGVHPSSENTVFAHVLLDSVFYEPFKPFTCLDKSATIPWDRVNDDYCDCLDGSDEPGTSACPDMEFYCPNVDHEGVFIHSSFVNDMVCGILANLIIAALLHKRYALMQSRALAKEREEQVQKRRKEIESGHQIYQEYVTRKAVELAEEAKRQAEEAEKRALEEAEKQMLNKSADSESDIEMPPLEGGKTEHIEEPSAAQANEDFIEDGDHEVEEDKQDDEWKIAKGVEEGASLPSGKLPFAEYKTQIRGGGPPYVLPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT28</accession>
    <name>A0A0R3WT28_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glyco_trans_2-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3903</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003267">
        <property type="protein sequence ID" value="VDM23726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT28"/>
    <dbReference type="STRING" id="6205.A0A0R3WT28"/>
    <dbReference type="WBParaSite" id="TTAC_0000391801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000391801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000391801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM23726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000391801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29083" checksum="FFCA78AF86CC654A" modified="2016-01-20" version="1">MVTKIGEISTAYRLPLRILVALLIVGSLVALWYYAFQTPFRKLVSSMVAFSAADIGGYEKGVALAFFGSIDSPEHKNCRLYRDRFPIKRDRDGVIDIAVTIAVYDDIRPVARIMRMIYRTNNYYCIHLNRDADHALQAAMKGLITCFDNNVELVPTNSSIALIRSGEGVLKAHLACAEQALRRNGKWKYLINIDDDEFPLRTNLETVSILQALNGANLVESFSTPSRDSLVGNKSLPLEVSRFVAYPAFHLADKLTIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT38</accession>
    <name>A0A0R3WT38_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3913</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003281">
        <property type="protein sequence ID" value="VDM23742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT38"/>
    <dbReference type="STRING" id="6205.A0A0R3WT38"/>
    <dbReference type="WBParaSite" id="TTAC_0000392801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000392801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000392801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10410030at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000392801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15541" checksum="88AB2527EAD5F351" modified="2016-01-20" version="1">MRHPPEQSNHRRLPSLTLQKEAKAKVLQPSALDLADPDKAHLLSWVRTPTKGNDNMWQENYPGLVVLSRDSANVSDMTLQVGDQKANGNFLSSPLSTQRKGQNCISFESDETGQLPDSEKVGHGKPVLPYSSMFIFAPTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTG5</accession>
    <name>A0A0R3WTG5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lebercilin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4040</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003538">
        <property type="protein sequence ID" value="VDM24041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTG5"/>
    <dbReference type="STRING" id="6205.A0A0R3WTG5"/>
    <dbReference type="WBParaSite" id="TTAC_0000405501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000405501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000405501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283759at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000405501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29764" checksum="4DBAA776DADE204C" modified="2016-01-20" version="1">MSPLGSSTPGTYVAPSLPTPSAQHKLQQQRRYRRHRSGIRGCKSSQQQRRQYHHRLQPSLETELSLEAWQASQNLIASLRSENHLLQNQLKECRVELRTVQRQCKVQSARLSKAVGREAEMPALVDRLNAEVRAMQIQLRRKQEAIDVAERRALEAEARLLPLLGKRNHKSATVSSPPSANEQEEMKRRTQALDAMQTTLEEERRKFRARRYWSLGDGTTEGDVGVEAAERTHGKWCALSDDRPFQFVLHLLHLCNLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTS1</accession>
    <name>A0A0R3WTS1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003775">
        <property type="protein sequence ID" value="VDM24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTS1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTS1"/>
    <dbReference type="WBParaSite" id="TTAC_0000416101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000416101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000416101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957665at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000416101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13849" checksum="2B4E82CF6D5A8A32" modified="2016-01-20" version="1">MIEIYGSDYLYASIPNLLEPLQGQGRETLEWRFIRLASDPSSNFNLHLYPVTLLDISHSPPTTSSSTTVSVLSSPLLPVSRLRRSHSGRSSIPPPAGKGTFWLGIGPNGFEFHEVGYSSNYSLLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUD0</accession>
    <name>A0A0R3WUD0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004216">
        <property type="protein sequence ID" value="VDM24739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUD0"/>
    <dbReference type="WBParaSite" id="TTAC_0000437001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000437001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000437001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10354244at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000437001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17348" checksum="7E238E57F2819C13" modified="2016-01-20" version="1">MSVDSLGSWGMKRKRRSRQFSQTLKSSITPAIPLLGQVIGENGESTNLDLDEGAFFGFCTDLRDSEVIRLIETIQRDDAKQFSSFVFKRIESLTMNVILTELPSAEYMARSFWNALNNIGLLHTACILSAHAIIDELLRRNVTFSMTDVNAAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV12</accession>
    <name>A0A0R3WV12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4586</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004825">
        <property type="protein sequence ID" value="VDM25232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV12"/>
    <dbReference type="STRING" id="6205.A0A0R3WV12"/>
    <dbReference type="WBParaSite" id="TTAC_0000460201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000460201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000460201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000986">
        <property type="entry name" value="Protein tyrosine kinase 2aa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000460201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17419" checksum="1D367F2F7D5C7273" modified="2016-01-20" version="1">NQEYVAHAGARFPIKWTAPEAANYSRFTTASDVWSFGILLTEIVTYGRVPYPGMHNAEVLRQVEAGYRMPAPPGCPAELYDLMLECWAADEAARPSFASIHGRLQVFCEEWDRPAYRDPATATSGTAVGANTTFERCESPPPPLPLYRRHVTTRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW29</accession>
    <name>A0A0R3WW29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005761">
        <property type="protein sequence ID" value="VDM25944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW29"/>
    <dbReference type="WBParaSite" id="TTAC_0000496901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000496901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000496901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000496901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7712" checksum="BED0DD167872B494" modified="2016-01-20" version="1">MYGEGHFTQCVWSDTRRAGFGYAKAREGDLAIVVGQYRPPGNYCGEFFAKVPPPLSGETWVPSVKELSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWA6</accession>
    <name>A0A0R3WWA6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5031</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006009">
        <property type="protein sequence ID" value="VDM26108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWA6"/>
    <dbReference type="WBParaSite" id="TTAC_0000504601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000504601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000504601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000504601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9334" checksum="CA333A601EB85C5A" modified="2016-01-20" version="1">MRIPNDLLISRFEILFDSTPPPSDASMRDLLKSRVKHVGADYRSFLHHWIHLQLLEYSSANRVDKVIAQISEAGDAEEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWP5</accession>
    <name>A0A0R3WWP5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COPIIcoated_ERV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5171</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006475">
        <property type="protein sequence ID" value="VDM26396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWP5"/>
    <dbReference type="STRING" id="6205.A0A0R3WWP5"/>
    <dbReference type="WBParaSite" id="TTAC_0000518501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000518501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000518501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="1">
        <location>
            <begin position="80"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000518501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24437" checksum="0E3861EFD84091C8" modified="2016-01-20" version="1">MDVLDLNGNLISSSSQIKATNCKFELPPKWDKRFKLKREQMKNLREQYHSLHQYFWLSHMDSEKFDLGPLHYFREVEALEAKADACRFIGTFKARKSPGNLHITTGRALGLNSNVHIHIAPLDPNGRRNFSHRIHHLSFGTPLENYIHPLDAEEVISDDPALMYQYFIEVVPTTFRTRLEEIDTYQYAVTEQVCTLLQRSISCDTPIQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXN5</accession>
    <name>A0A0R3WXN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007798">
        <property type="protein sequence ID" value="VDM27127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000552501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000552501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000552501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000552501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15518" checksum="6295C14A8BCF1FED" modified="2016-01-20" version="1">NQSVFRTDSNEFIRIKPITPHQRQPSVYPVTPDSHASSDTDGSSESPADGAEPRGRFVFNARNGASVASTSTIRLAPATGSVYAATGRYNCPTPYVSRQSDDSGYCVDFNGDYIGGYETANSPTAYRQQAMFQSSPFLMRLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY47</accession>
    <name>A0A0R3WY47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5673</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008517">
        <property type="protein sequence ID" value="VDM27422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY47"/>
    <dbReference type="WBParaSite" id="TTAC_0000568701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000568701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000568701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000568701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="6889" checksum="402A6C346D1AE7F4" modified="2016-01-20" version="1">MKGCRIDTAQVFEDRIERGYYRLDLVFIAGLLNTVGVQSTAAMKLLTGSSEFAHQTSSICTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZB5</accession>
    <name>A0A0R3WZB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6107</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZB5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000612201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000612201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000612201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="10">
        <location>
            <begin position="97"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000612201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="738" mass="83443" checksum="C675823EE5136EC8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZC3</accession>
    <name>A0A0R3WZC3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Scavenger receptor class B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6117</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZC3"/>
    <dbReference type="STRING" id="6205.A0A0R3WZC3"/>
    <dbReference type="WBParaSite" id="TTAC_0000613201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000613201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000613201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254507at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000613201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55822" checksum="0D8BAB65DF9D2823" modified="2016-01-20" version="1">MWEFFTMLQHCVMDSILDLHVDRRRTVSFYLFNLTNAEEWQTNGTKPKLRAVGPYRYRRITKKSDIHFSEGSCGQRVLEYKLSTVYHFEPNGFTRDPRQDRLIVPNFVEGIANSMIKQAGSLGTRAVWYFLSKPLLLNLTAEEIMWGHEYGNLVAGRVLGMVEDAKIGLFNRLNNTIYGPYKTDTGNINISRLGALVAFEGKTQLDKWGSDYANMLNGTADIITPPSVKMGDRRYMFSTEICRSVPLVAKKWVSAKNFPQLKLLSLEIDSKVFLSADEDPDNAAFHAHVYPTNKYPPTGLLSISPCVDFGIEGDEPLFISLPFFNQAADEVKDSVAFDGLIEPHLTSQVHVDPKTGILVEGELFFQINIFLSKTIQRTPKDIYFPLAYINECALFVVLHTLQMPIPLLLKTTYAEQESAKQLYRMVYETPEVIRRALRSLLGLSAILAVLFSISALILHWREHRHLFAPSEVNCGLEEGSLKEEDSFYCMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZT1</accession>
    <name>A0A0R3WZT1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6309</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZT1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZT1"/>
    <dbReference type="WBParaSite" id="TTAC_0000632401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000632401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000632401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005277">
        <property type="term" value="F:acetylcholine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF13">
        <property type="entry name" value="VESICULAR ACETYLCHOLINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000632401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="584" mass="64834" checksum="FD34F1572C634D53" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZT5</accession>
    <name>A0A0R3WZT5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6313</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZT5"/>
    <dbReference type="WBParaSite" id="TTAC_0000632801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000632801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000632801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254902at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000632801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16667" checksum="80E38A477D164E4B" modified="2016-01-20" version="1">MGSMLESIFFVITTLFSLLFLILAVSIESWPCGGVFANSCQVNLKNYPILPIGVLICISIILYAIAACMDLAQIYLHQLNDRVRHIVAYVALGTSVVSSLFVVSAMLAFFNLYMGSWSIMLSVVGMTLGCSITFQLGMRILFDLLGKNVDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0B3</accession>
    <name>A0A0R3X0B3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6538</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0B3"/>
    <dbReference type="WBParaSite" id="TTAC_0000655301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000655301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000655301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000655301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18763" checksum="2B008DE94D5A781F" modified="2016-01-20" version="1">MESTKAGGSDSESSSDAQSPFSSEPVPEQTGTNVENCATESNANNKRGEPYDDSDDDWYDNEDTLIKLEEGNVVVGCYKSSTQFNRNEAIDYFQRQLAKMSSDPKYWKVDECDMLPLKRTTPATFRIYCPAPFADGRVTNIITVLVDPAAFVVNLGTTTENAQTGRSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0H7</accession>
    <name>A0A0R3X0H7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-3CxxC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6621</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0H7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0H7"/>
    <dbReference type="WBParaSite" id="TTAC_0000663601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000663601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000663601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000663601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17129" checksum="EE493789B6A67CE0" modified="2016-01-20" version="1">MPCYEMVSCFQCSTCVITWISGAICPRCYSLKSRFGDPKPCTICQLPMAFGSALVCQRCLHYRTKFGDPRQCEKCLHMCAFYKDEVTTLLFPFTLQHLIKDLSAVKRPKAEEYTSRHTSNRSGNSTNYRYVATAPFVFRMHFLQTSYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0J8</accession>
    <name>A0A0R3X0J8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PPIase cyclophilin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6644</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0J8"/>
    <dbReference type="STRING" id="6205.A0A0R3X0J8"/>
    <dbReference type="WBParaSite" id="TTAC_0000665901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000665901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000665901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF25">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000665901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="900" mass="99013" checksum="7767C8A11C814509" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0R0</accession>
    <name>A0A0R3X0R0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6727</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020319">
        <property type="protein sequence ID" value="VDM30981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0R0"/>
    <dbReference type="STRING" id="6205.A0A0R3X0R0"/>
    <dbReference type="WBParaSite" id="TTAC_0000674201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000674201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000674201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="243"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000674201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64752" checksum="2750686FFF200015" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Z6</accession>
    <name>A0A0R3X0Z6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6823</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020325">
        <property type="protein sequence ID" value="VDM31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0Z6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0Z6"/>
    <dbReference type="WBParaSite" id="TTAC_0000683801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000683801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000683801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
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    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000683801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21805" checksum="EA6A992B64EDDCFA" modified="2016-01-20" version="1">MVSPPVSPGVASTESRAGIRDPRKLSTKGESLYELLGIPKDATTEEIRRAYRRLALRCHPDKNPDDPKAGEKFAELNRANVILTDATKKEIYDKYGSYGIYVSETVGEEAAMTYLKLNNPCLKCLFLTVFFLTGCCCCLCCCFCCSCCRKVPEEDLVDMAPESDEEAYQNASDKGDRAPEQPISSEPIVLPPPNDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X113</accession>
    <name>A0A0R3X113_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6843</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X113"/>
    <dbReference type="STRING" id="6205.A0A0R3X113"/>
    <dbReference type="WBParaSite" id="TTAC_0000685801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000685801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000685801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9987040at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF305">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000685801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="678" mass="75354" checksum="2C6379A57BEDDC1F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X172</accession>
    <name>A0A0R3X172_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid-sensing ion channel 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS6914</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020331">
        <property type="protein sequence ID" value="VDM31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X172"/>
    <dbReference type="STRING" id="6205.A0A0R3X172"/>
    <dbReference type="WBParaSite" id="TTAC_0000692901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000692901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000692901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000692901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30956" checksum="6BF915B37D1D8215" modified="2016-01-20" version="1">MGCRSSLRVAGYTARELRALALLAEALITLAILCLLTFRVLVWWRAEGYQRKSTFREEGGSNQDSESETLLPSLIFCNANPLRATALYYAGLYDKVSQAVQDPRFTLQDLDFSSEQLQQYAHSIYSMLKRCRLNNAECNAQNFESVRTKHGMCFRLQIPRGKQTRLEMILDPEESEYVLPNDGFTGFLIVLNCSTSDQSEFFIGSGFHNMVRISSADPHSGMACDSGGFQLRVDSITQTVRSALYQSFLPRDLSGDSTAEAERTMKRQTTDLDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Q8</accession>
    <name>A0A0R3X1Q8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5745 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7150</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Q8"/>
    <dbReference type="WBParaSite" id="TTAC_0000716501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000716501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000716501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044039">
        <property type="entry name" value="DUF5745"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19016">
        <property type="entry name" value="DUF5745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5745" evidence="2">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000716501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39247" checksum="A9F545294A757531" modified="2016-01-20" version="1">MSGVSCSRSRSAVRSGRGLVKSVVPVSNSHTSGSEHQNSSGKGSDADYFVRVYADIFGMDRIPYPNAHSAEQRFFNIEAIEKDIESRFDVTLSHIPPCHVVDRVSTAVEDLNEIMENIDFAKRAHKCISAEAFVSDMRRSISPEIPRGTVNENLPPCSEKPLCGKPLYRHLANESFALISPPTALCEQSVPEIVKNSSPKSPPDSGVTAVAPKPIVFDLNGPNSSFDAVSFLSEKIREARSQAALLCGLCTNRVQKRWTPELCELRNCLIKLGGDIEATVAAIDTLSPNPLDLLDPDTTTATSIPTDLDEVAELYRLNTECERVLAEKKKLMLDSVTHCVRQLKGAINPLPKNMKNATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2C3</accession>
    <name>A0A0R3X2C3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020371">
        <property type="protein sequence ID" value="VDM31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2C3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2C3"/>
    <dbReference type="WBParaSite" id="TTAC_0000743201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000743201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000743201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000743201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="503" mass="54056" checksum="7F3C547BD5416A71" modified="2016-01-20" version="1">MAQLRHRITVLKDLSSLEYLEALQVHLLRLMHSPFSCIAEVVFDADVTAIVTDHVLKQGRKPLSALHGIPVCLSNCFPVKGEDCNASAVFMAGHSQSNDCCLVQDLRKVGANPVALASTGLLPGEIDASSRLYGTVPHPTHPNRVVGSTSIAVIVEQKGAFLGFGLDVLGDVRLAAANVGVVGFKPTAQRLSTGGIVSAVNFHEFLPPTVGIVGSCVPDISDAMESLALAHTDLSTPPVPFKTDTSKESLTIGVYKNYSSIFQVVPAVRRVMAEATAALKAKGYNIIEVELPDPEEAFFLALQVILSCGSHWDIHVGQHYGSSLTWNEIIKCCLPKIPLSLRGLLGLVIQCQQKAKCKDMKQLLKAWKKPLSAECIHKGLEAYRRKFSDFWSDEEIDLLIGPAAPAPALLKGAPSSLALLQAGYATIFNIVNCPAGVVPFSKVTQEDVELAAEVNAAPKSLNALLQAHQKTAEGLPLAVQVVAKPWADELALRIMQELQEVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Y4</accession>
    <name>A0A0R3X2Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7663</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020392">
        <property type="protein sequence ID" value="VDM32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000767801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000767801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000767801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="64"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000767801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51954" checksum="F8898C090349AA9B" modified="2016-01-20" version="1">MLRSDTTPRVSNVTTNSGDGRIIPDMSGLVALFGTGTYSSHQIPEVRQILICCHAILILCGTTFNLAVLFALIYFKEQIFTNIANIFVFTLAASDVVLCGISMPIQLYYGIDENSRVNTALCRTLFAGFGIPMYVSCLTILLIAVDRYRLIVKPTAPRASIRTALCLILITVTFSALSAIPVGVYTESRGIEGFRNYCVEAWPKPIFRLIYSVATFILHFLLPLLVSGGLYLEIYRRLTVRPEQLSLSKESGRRKRRTTTLLACVVVCFVICWTPWCVFSLLVEIDAFVTKGSSAPHIQVNFSELTLEGCTAWLTDGALGDNQTKVPQKIYFSQSSSFIHITHFTLVDMVLKLWAMGSACINPFLYGWLNRPIRRAMTTVYVLSPRLCFRSMTQRSGCGNHEPEIFSRPSKVSSHSGCGKYPQAKRNLDQYYHRHGQKRTSLSQSSRKKEEIKYLGMECRCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3A1</accession>
    <name>A0A0R3X3A1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ELAV-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7798</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020406">
        <property type="protein sequence ID" value="VDM32256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3A1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3A1"/>
    <dbReference type="WBParaSite" id="TTAC_0000781301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000781301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000781301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="417"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="616"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000781301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="865" mass="92285" checksum="D26C16B39BD7BC6C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3U9</accession>
    <name>A0A0R3X3U9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ysc84 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020434">
        <property type="protein sequence ID" value="VDM32516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000804501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000804501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000804501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10435800at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000804501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19602" checksum="0F54B6679C736B5E" modified="2016-01-20" version="1">MLGTVVVCSSSASFTFIGLPRNYKVEAEIDAVGIEQGRQLLGHDMQIEDDRFFAGRLSSMTSFQASEYNAIGEEQERCGTKAMEIQRHLKPIVSGSYGGDEVIAGELTGFSEPSSPRTMKPGMPPTPLNSVVITDADIANLIPVDASPQTIRRLLESAVAEATNVIEAEPKKPSSKTELTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X472</accession>
    <name>A0A0R3X472_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein NDRG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8179</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020459">
        <property type="protein sequence ID" value="VDM32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X472"/>
    <dbReference type="STRING" id="6205.A0A0R3X472"/>
    <dbReference type="WBParaSite" id="TTAC_0000819401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000819401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000819401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000819401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47814" checksum="1D1873BABE29EA5E" modified="2016-01-20" version="1">MEMSQIRKTAKVPSVGFVGVPLEDNTTISHPVLSHESSGVLEEYEIVTSSGIPIRVYRQPSNSKSAILTYHDIGTNHTSFLGFFSYPEMQVISRHFTIYHVCAPGHHEGAEPLTLNPVEGETSLLRSNEERNISTTGEDSLFGRQSAYQNVADDSVTSTTTSQYPRMDELAEMLTSVVDYFKMKYFVGFGMGAGSNVLARFALRHPDNVLALFLLNPNGTTHGYYEWFRNRWSDLPNLQRGFFTDNLLSQLEAHWFGFGLAENHDLVAFYTQLARSLNPINVAGYIDSYINRTDLGLVRCLDPPSVIEQREREAGSQATQPTAIKVNCCLVTGALAQDLARALSDLNGRMDPRKTQFLLVPDCNGFLMEEDPDKLAVNFLHFLRNEGFLVSMTPEKLHKEAAALQMELARRTNQDLPNSAFMLEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4D9</accession>
    <name>A0A0R3X4D9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8255</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020473">
        <property type="protein sequence ID" value="VDM32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4D9"/>
    <dbReference type="STRING" id="6205.A0A0R3X4D9"/>
    <dbReference type="WBParaSite" id="TTAC_0000827001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000827001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000827001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="148"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000827001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="35510" checksum="B683918DBDFA98A5" modified="2016-01-20" version="1">MSGGAKSFIDRLRIYVRSGSGSPGNPLIHGKGGNGGSVYLRSVEGQTLNGILDKCPKKRFIASCGKPCSARRGICFGSNAADIEVSVPVGISVSISNPGEPTRLIGDLDKPNQRLLVAQGGYGGTPVTNYLGTPGEARSIVLDLKLLADVGLIGLPNAGKSSLLQALSGAKAKIAAYPFTTLRPQIATISFPDHRKITMTDLPGLADIAAKFDINQQSPPPLRHTAFLKHVERTACILVVLDALGFQANQHAPLRTPLAAAVLLVSQLQRYAFGRLLGKPMLCAINKEGLRHWLDVIDMRRKKKDFDEAEKSLEGAIESALKDHMPTTYENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X566</accession>
    <name>A0A0R3X566_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8575</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020535">
        <property type="protein sequence ID" value="VDM33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000859001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000859001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000859001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259343at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1638"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000859001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1898" mass="208317" checksum="34506ED87635C999" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5I4</accession>
    <name>A0A0R3X5I4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TF-B3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8713</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020567">
        <property type="protein sequence ID" value="VDM33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5I4"/>
    <dbReference type="WBParaSite" id="TTAC_0000872801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000872801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000872801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242124at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000872801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38602" checksum="DA5E00607E31E1BB" modified="2016-01-20" version="1">MSRSCGAGFRHWRERKKSLTPWLIGLRNPELVRELVDVIPFIYLCCKLSVCEQSWAAQPENPKAVVVKTSDFLRLCDGQFWIELLLDGSIKERLVCGWDCFVAHANEVKFVKETHCLAEAFGSIPCIMTCKEDLLVQPSASYECFDLVTYYSLVYSLSDTLDFRDYSSGGDNEMNGPSSTHSCGNASVTCAMEEKQLNTGNGADVGRQDVFQTVDQWVPTQNASDESLAGFAEVETHGCMDFSCAHENALILIGASAQSTGAPQRGKDVSGNRTLTNNDALGAEGDLSYLLRISPTPPVKAISNSDIPLFSGDTPPLLNSSNPGNPRDVNSSRLCLLGNLVNVPAVDRSNDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5R7</accession>
    <name>A0A0R3X5R7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8812</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020593">
        <property type="protein sequence ID" value="VDM33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5R7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5R7"/>
    <dbReference type="WBParaSite" id="TTAC_0000882701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000882701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000882701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245173at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23599">
        <property type="entry name" value="TFP_LU_ECD_Cold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000882701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135841" checksum="56747C8672E2E297" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X690</accession>
    <name>A0A0R3X690_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020651">
        <property type="protein sequence ID" value="VDM33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X690"/>
    <dbReference type="STRING" id="6205.A0A0R3X690"/>
    <dbReference type="WBParaSite" id="TTAC_0000901401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000901401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000901401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000901401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34200" checksum="A59C7C5488F59D3A" modified="2016-01-20" version="1">MEDFQYLERRKLSAIRMKICACREAKHELSRNFSRLQVHMKYVGKVLESTFSTFAKFSAHLYKLRKENIRELFQRFLPLKIATSSTDLDKIFGTPLNMDSRLLSVPEPTISSHAALTHMLLAQRTMARILDIWIPLDTQCLFRLNIFDDDSPLRDSITHVYRVVNQVIQLIFEVGVNTAFSSNSLSSQVVLPTKALLEQNRPLLKLHLLAEAFHHDLMKAQGDMFSSIGHEFALCPRSHKGKFNRSSVLIRRVGEGRTRSGVPAAKRPTVGGCVTQNLTNDASELTLMDWEIIPRDAFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6A2</accession>
    <name>A0A0R3X6A2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9012</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020654">
        <property type="protein sequence ID" value="VDM33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6A2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6A2"/>
    <dbReference type="WBParaSite" id="TTAC_0000902701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19512">
        <property type="entry name" value="RecA-like_ATAD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000470">
        <property type="entry name" value="ATPase family, AAA domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="340"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="585" mass="67074" checksum="71CF14F2EB018E98" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6B4</accession>
    <name>A0A0R3X6B4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disks large-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9026</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6B4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6B4"/>
    <dbReference type="WBParaSite" id="TTAC_0000904101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000904101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000904101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036956at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000904101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="742" mass="81212" checksum="D2C8D4F0B7BA4E6C" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Y9</accession>
    <name>A0A0R3X6Y9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9284</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020748">
        <property type="protein sequence ID" value="VDM34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X6Y9"/>
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        <property type="protein sequence ID" value="TTAC_0000929901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000929901"/>
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    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
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    </dbReference>
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        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000929901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22825" checksum="AD90DBAC4B40463C" modified="2016-01-20" version="1">MVGPGMCRPGIRGIRSSDINRLFFLTDQQDGPYEGRMFQRLSYISDDITKLAVDAIVNAANSSLLGGGGVDGAIHRAAGPGLLKECRGLGGCAVGSAKITGGYNLPAKYVIHCVGPSDGSAEALRSCYKTAMRLCTENGIKSVAFPCIATGIYGFPNMPAAQIALRTVWDYLEAHDDIERVVFCCFLDEDYRIYQELLRVKYQEFTSSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7A2</accession>
    <name>A0A0R3X7A2_HYDTA</name>
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        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9410</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000942501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000942501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000942501"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
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        </location>
    </feature>
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        <location>
            <begin position="517"/>
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        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34196.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000942501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64089" checksum="057272410AEB3B5C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7U5</accession>
    <name>A0A0R3X7U5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9605</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000962001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000962001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10595192at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000962001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24495" checksum="DB022BEB245CAEE1" modified="2016-01-20" version="1">MHLWKDIFCLSRVQKQQQQERQQSRSPHGATSSVCLHKRTSSSCVFTETPLLQVPPRAQMHSRARLPDTWLDDRRRRKLCSWELERLQRLLEHSATAMFADSASASNVGGDGGGGIDSSTSPTTTTTTATSPPPPNADLEERLSAQMAQRFNKMELNLLELEEKMTTTFVSLLSHLQCLQTHPRADVDASTMTEMVKSGDEEEIEVNVRLIDTSNGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7U8</accession>
    <name>A0A0R3X7U8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9608</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020923">
        <property type="protein sequence ID" value="VDM34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X7U8"/>
    <dbReference type="WBParaSite" id="TTAC_0000962301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000962301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000962301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UME" evidence="1">
        <location>
            <begin position="754"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000962301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1912" mass="213978" checksum="3B3108620AA77C4E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Z9</accession>
    <name>A0A0R3X7Z9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9659</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020963">
        <property type="protein sequence ID" value="VDM34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Z9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Z9"/>
    <dbReference type="WBParaSite" id="TTAC_0000967401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000967401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000967401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042941">
        <property type="entry name" value="KLDC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47196">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47196:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000967401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="35987" checksum="5AA378C1747437D4" modified="2016-01-20" version="1">MGDYLFIHGGISNASEKSQVCRNSLYKIRVFPSLGEWTELTTADSPFLSQHKCIPHYSSGCLCFVGGWTGKVRSAGVHVFDTNSGRWLPPALQEPHLKGLPKGSGLSGHSLTPIVTRGNQVAALVIGREGSLRTQRRHGNAYILRGKINGSLKQNGSGDPGRSQSSFVYTEMLSTTASRSYHTTIPVAAHTVLTVGGRATGFAEIVTTPNEVVLDVESGQCKAVSRLIEKFTETESSPIAESKLDKIGIRGHYAIAGGHGVLIGGGEGFNALRKDPSSEAFICLPSVSNSVFSLGKMKDRRCYAVCAVNATDGTAWLQGGLGGQKKPLRSLARLICAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8A4</accession>
    <name>A0A0R3X8A4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9764</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021035">
        <property type="protein sequence ID" value="VDM34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8A4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8A4"/>
    <dbReference type="WBParaSite" id="TTAC_0000977901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000977901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000977901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="777"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000977901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114454" checksum="AC55111E3AFFF564" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8C4</accession>
    <name>A0A0R3X8C4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9784</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021047">
        <property type="protein sequence ID" value="VDM34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8C4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8C4"/>
    <dbReference type="WBParaSite" id="TTAC_0000979901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000979901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000979901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="250"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000979901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55617" checksum="C9E7D3B234EC7E92" modified="2016-01-20" version="1">MRTDLKPSQHLVSEDLSAGKMKVSVEGDAAKDVDLLTLEDIRDQIRYIEKAVATKELHFMTRVLRGIVPIRRKLNSNVLRGLVYTYFAPQSQQWNYFMEFLPEAMDAPPKLNVKPKSQKSGTLFPEVEVYLHLLLLIHLLDSGSTKEATRCSTLLMERTQETGRRTMGVLASRCFYYHSRAFELDDRLEEIRPFLHSRLRSATLKNNHDCQAVLINLLLRNYLHYNLHDQASKLVNRVDFPESAPNNEWARFLYYLGFIKAIQLDYNAAHDHLVSAHRKAPQQTAIGFKQALHKLNTVVELLLGELPDRSIFRQEDLKDALHPYFQLTQAIHAGDLGRFNHVLKTYVQQFNRDKTYTLILRLRHNVIKTGVRRISLSYSKIYLTDVAAKLQLDSSEDAEYIVAKAIRDGVIEAVINRERGYMITTEASDLYSTREPMDQFNQRIRFCLGIRNQAIKAMRYPPKQYSKDLESAEVRLCRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9K9</accession>
    <name>A0A0R3X9K9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021437">
        <property type="protein sequence ID" value="VDM35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9K9"/>
    <dbReference type="WBParaSite" id="TTAC_0001023401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001023401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001023401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001023401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7608" checksum="3F640A434FE47B54" modified="2016-01-20" version="1">MSGLITCSPWGLRDQEVGGRGDLDPLWLTRLLERQEPYDTEVAIPIESTDVGRHLKRNYARPAIRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9V5</accession>
    <name>A0A0R3X9V5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10315</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01021538">
        <property type="protein sequence ID" value="VDM35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9V5"/>
    <dbReference type="STRING" id="6205.A0A0R3X9V5"/>
    <dbReference type="WBParaSite" id="TTAC_0001033001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001033001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001033001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="74"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="260"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001033001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49309" checksum="F0E13DEB03A43CC7" modified="2016-01-20" version="1">MADENELLDYDEEDQETVQDSKPNGDLQAKKAVKGDYVTVHSSGFRDFILKPEVLRAIVDCGFEHPSEVQHECIPQAILSMDVLCQAKSGMGKTAVFVIATLQQLDPEEEGITRVIVLCHTRELAYQISKEYERFSKYMPKIKVGVFFGGMPLRKDIESLNKCAPHIVVGTPGRILDLIRNKALRLDHIRHFIIDECDKMLDTLDMRRDVQDIFRMTPRNKQVMMFSATMSKEIRPVCRNFMQDPLEIFIDNDSKLTLHGLRQHYVKVKENEKNRKLFELLDELQFNQVIIFVKSVQRCIALAQLLVDQNFPAIAMHRAMSQEERLERYQAFKNFHKRLLVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFISDEHDANILNDVQNRFEVNISELPDVMEIASYMEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA93</accession>
    <name>A0A0R3XA93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021718">
        <property type="protein sequence ID" value="VDM35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA93"/>
    <dbReference type="WBParaSite" id="TTAC_0001047001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001047001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001047001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001047001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9333" checksum="D975667E13E67BB0" modified="2016-01-20" version="1">MFLLPADANATFRDPPCDDPLDLQWCVETGHIPPLPTSNALVVVLPPFNLETSLAPSFILPLPDLLSMDVVVIAIAVLLQTLTAEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAY7</accession>
    <name>A0A0R3XAY7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DAZ-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10697</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022070">
        <property type="protein sequence ID" value="VDM35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAY7"/>
    <dbReference type="STRING" id="6205.A0A0R3XAY7"/>
    <dbReference type="WBParaSite" id="TTAC_0001071401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001071401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001071401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001071401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="33221" checksum="6987E36E3EDFA6B6" modified="2016-01-20" version="1">MNTTIRGPTEPYDASNCSEADALTYGGWLSPEGLQALSQGMPIGSGGGGGVGGPGPMVGPGGGGGNRYSGGPPRGGVPPPHPPPPPAMYLGRQPQLQQQQQMQQRGVGGPPMYQQPPPPPPPPPPSQFAPRGLPPRQQQWGYPDGYGDAVSAVGSGGYPGYPPPPPPQQQQQQPQQQQAPPMPVAPPIQQSAVLGAGGVGVGGYDNAGLYAQPPQGAGYNVPPPQVTAGGPPAAAAAAMYRMNAPLNNPAAAAAAAAVAAAAAAATGGGGGVGVGGAPIYGGLAPPTVPGGGGPPQPPAPVPQPSPYGYAMGPAGAAAAAGLPAPNVPPPTAATAAGYPPGAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBR1</accession>
    <name>A0A0R3XBR1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10970</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022631">
        <property type="protein sequence ID" value="VDM35950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBR1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBR1"/>
    <dbReference type="WBParaSite" id="TTAC_0001098801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001098801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001098801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="198"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001098801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33071" checksum="022B1AE4A681421E" modified="2016-01-20" version="1">MDPLNCSRSTPRQLKVMQVEDLVEADTFPLHNSSPRGFCLPCLRLALADDGQKVDEREFKNLNSDGDKSLEDIKQSQQSSTSTIGQIYTDILKRTIGFGTKQTTFPKVEATTNGSGGYNDYDDDINVGTDEEDAETYSQAHFTKTSSNNGPANSNGSFESYHALVGYESQTTSTATPSVAAVSSVAIAAAAAAAAASAKQKRHRTRFTPGQLNELERVFAKTHYPDIFMREELALRIGLTESRVQSDWSGGGDGVEDQDKRGSGGLWRRWRYEQGEGGGTRQQMLTPRQNNFVLEVKATGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC07</accession>
    <name>A0A0R3XC07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11067</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022857">
        <property type="protein sequence ID" value="VDM36047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC07"/>
    <dbReference type="STRING" id="6205.A0A0R3XC07"/>
    <dbReference type="WBParaSite" id="TTAC_0001108401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001108401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001108401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001108401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8286" checksum="46A33630F572C268" modified="2016-01-20" version="1">MVRHEAAMALGEVAGSVEAEEKDSDDNSLAMRARRALLRGCNDPEPIVRDSCALALDMANYVASNERFQFAEVPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC94</accession>
    <name>A0A0R3XC94_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11154</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023081">
        <property type="protein sequence ID" value="VDM36134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC94"/>
    <dbReference type="STRING" id="6205.A0A0R3XC94"/>
    <dbReference type="WBParaSite" id="TTAC_0001117101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001117101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001117101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6226968at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001117101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36604" checksum="C56EB4B1361BC2D1" modified="2016-01-20" version="1">PTIVIQPKPVGSCVEDEPVSFRLQYEPSNDPNLVVHWYKDGEPLTNGTRFHVEYERGVASLLIRHTIPEDSGTYACKIANSAGTIESDHLDLQCSPSAAIITQSNLLEGSEGFKLIQAIEHGSSAYDSSTRYADEEQTPTSPTIDVEPKPAEIILGSPVRFLVRMSGHPTPEIEWFIDGQSVHQDSLIKVLSDGGISVLEINKIEISLGQHEIRVRGVNSQGTVEANTEMIVHPADYKLPDLKHVMPENPFRRQAQLKHVQRTEELSKAFSKAKPKPEQIIHMEQTSELRAKTFRSPEVVAAEELLSKVTTGLRKSNRTVAKHGTEFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD04</accession>
    <name>A0A0R3XD04_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11413</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024072">
        <property type="protein sequence ID" value="VDM36411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD04"/>
    <dbReference type="WBParaSite" id="TTAC_0001143101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001143101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001143101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001143101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10064" checksum="49F9362EF8AD0FCD" modified="2016-01-20" version="1">MCTFCLLKGARDSNMVEFKSPFSMSLFMVSPNREERIQINHPAASANCSDVPIFRLVKVALSHSSSQPDSGSVSLPEWFALPSNLNKHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDA6</accession>
    <name>A0A0R3XDA6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ERAP1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11516</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024634">
        <property type="protein sequence ID" value="VDM36824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDA6"/>
    <dbReference type="STRING" id="6205.A0A0R3XDA6"/>
    <dbReference type="WBParaSite" id="TTAC_0001153301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001153301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001153301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273601at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001153301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11129" checksum="97663CBA89D4F8C8" modified="2016-01-20" version="1">MSGENEEEVGLLLHDRATLNDERVRVLGSLGATTNGDLMQRLFELTFTEYVRKQDRTHALLGVTGTPGGRRALWNLVRGRIATLSDDLGTSHLLARVIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDM7</accession>
    <name>A0A158RDM7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS992</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Microtubule organizing center</location>
            <location evidence="11">Centrosome</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus end of microtubules and to the centrosome.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000149">
        <property type="protein sequence ID" value="VDM17280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDM7"/>
    <dbReference type="STRING" id="6205.A0A158RDM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000099101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000099101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000099101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM17280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000099101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="49982" checksum="AA190219B70D73FC" modified="2016-06-08" version="1">MVLSERQRDELHQAIADYLRSNGYEQALNEFKREASLNPNIETKFAGLLEKKWTSVIRLQMKVMDLESKLAEAERENKQLQTSVGYGPVGAAPGSGLPGRGGDRRGGVDAIPRPPAKYTLTGHRSTVTRVKLHPHYNVFVSASEDATIKVWDYEAGEFEATLKGHTDAVQDVGFDPSGNLLVSCSADMQVKLWDFTTYTCIKTLSGHDHSVSSVCFLPSGDFLVSASRDKTIKIWEVATGYCVKTLTEHREWIRCVRPNPDGSLLASCSNDQEVRVWTMGGSARDCKALAVLHGHEHVVECVAWMGPSNPQAAKDIAAAADKSENGAFQQQQVNGDIASIGSTTSDDAPIILASGARDRQICIWDVRAATCLFILTGHDNWVRQLVFHPHSKYLLSASDDKTVRVWDLRNRRCHKTLEAHSHFVTTLDIHRTAPFLITGSVDQTIRVWECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDV6</accession>
    <name>A0A158RDV6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyco_hydro_38C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDV6"/>
    <dbReference type="STRING" id="6205.A0A158RDV6"/>
    <dbReference type="WBParaSite" id="TTAC_0000615701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000615701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000615701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257990at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000615701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26396" checksum="0C755EA2132DEBB3" modified="2016-06-08" version="1">MLFRKQIDGGLTTPVVQRGRLDPLWADVLGDLKVLVDEESKMVVRVPRTHAYAGQYQCACESTDTAKTLVLSSPTAFESTDFLTEAIFQLNYTVVYEGKEVYQGSGASGVIELATRGMGGFFHMLATGVTLADNLRTTTEWSEDGERKNYETVYSQEERVQLYPGVKALSNWTELVNRVETQAVYPDAEDNETVIYRWSLPSQMPGSNITNVFHIVGKLFVQLISTGVGRQEKATAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDX0</accession>
    <name>A0A158RDX0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6228</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000624301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000624301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000624301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000624301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1326" mass="147087" checksum="4CC0C57473DC3749" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REU2</accession>
    <name>A0A158REU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8059</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020439">
        <property type="protein sequence ID" value="VDM32550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REU2"/>
    <dbReference type="STRING" id="6205.A0A158REU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000807401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000807401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000807401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072647at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000807401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="108471" checksum="7A4068F6DE1635A7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REU7</accession>
    <name>A0A158REU7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 251</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8109</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020449">
        <property type="protein sequence ID" value="VDM32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REU7"/>
    <dbReference type="STRING" id="6205.A0A158REU7"/>
    <dbReference type="WBParaSite" id="TTAC_0000812401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000812401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000812401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4899631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF13">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043136018" description="Cilia- and flagella-associated protein 251" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000812401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120942" checksum="49B1D23B841DD305" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF21</accession>
    <name>A0A158RF21_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8637</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020551">
        <property type="protein sequence ID" value="VDM33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF21"/>
    <dbReference type="STRING" id="6205.A0A158RF21"/>
    <dbReference type="WBParaSite" id="TTAC_0000865201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000865201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000865201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="277"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000865201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="802" mass="88260" checksum="8C5D4D13E1BEEAB5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EHL4</accession>
    <name>A0A3P7EHL4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000828">
        <property type="protein sequence ID" value="VDM19146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EHL4"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM19146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="395" mass="43470" checksum="8B182741CAF33303" modified="2019-02-13" version="1">MKRVAPRVIFIESQQCVVAMSLGTVSSFEELGLDDQVLFSVKRLGWKIPTEIQAASIPHALKGRNLIALAETGSGKTGAYTLPILQELMLSPKHYFALILAPTRELAAQVQAQCVALGHSIGLNTALLVGGSPITDQANLMAVKPPHILIATPGRFVDHLKRTKGFDEVKFKNLRFLVIDEADRMLGSDFESVIEKILIVLPPSRQTFLFSATMTEKASSTLHHCSFCLTSFYCDWTSAFHIASLRDPVRISTRKSKFQTVESLRQYVLLVPQAELESYLVYLVRTAFSPLPSPINGLEAIKLATDEIGIASAESRTESVGSAIIFTRTRETSNKLSLLLRQFLTTPVITLNGDMPQAQRLGAIGKFKRLPTSCLVATDVAARLVPFCLIGYLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ENY0</accession>
    <name>A0A3P7ENY0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000319">
        <property type="protein sequence ID" value="VDM18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ENY0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="54" mass="6740" checksum="FAB6751BCCB34228" modified="2019-02-13" version="1">MTELEKEFHFSHYLTRARRYEIASELGISEAQVKIWFQNRRMKLKKRLKSNRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EW84</accession>
    <name>A0A3P7EW84_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS4138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003753">
        <property type="protein sequence ID" value="VDM24266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EW84"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM24266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="304" mass="34200" checksum="122FCF964B055068" modified="2019-02-13" version="1">MCVLDPSDYSAAAWLVACSEYRNRADLWQRTVAAVFLTYCLSLGGYPMAWFGETDLFYSPPAPKSRPNSLPASWVAACMLYHLQSVPVNAHGHADDVFFSLQNLSSYAMREVFSALYPTLSLVNHSCDPSAFRTCTSRATCFLSALRPLTAGTEVFDCYIDCFSLKPRVDRRRELSSHYLFQCVCEACTKDWPTLSDPKRHQMEFLRCPQCSGIVHLPARRCPHCRSTRALTSYNQLVNVEIPKQMELISEGVVGVDAVEIAGELLKKLNQLVLRPGTVWDQAQELFKMVVNFTRGSWTLEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F4Y9</accession>
    <name>A0A3P7F4Y9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008641">
        <property type="protein sequence ID" value="VDM27486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F4Y9"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="98" mass="10758" checksum="785E3F9B0A00B35B" modified="2019-02-13" version="1">MTAESVKELRAFSLLRLMFPSGLQVALLLLALMVTLVSERVLCPTPTLLHIAMHVAVGVIAFIGVLGVTMWEEKSTVAMFSGTGFGRILDRLYHLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFB0</accession>
    <name>A0A3P7FFB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007595">
        <property type="protein sequence ID" value="VDM27027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFB0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="49" mass="5652" checksum="7E843835BE7A920F" modified="2019-02-13" version="1">MVLRFVRPRLKDSQRGLVALIFKAYSVHRDDNRILDILVSILQVIMANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFH8</accession>
    <name>A0A3P7FFH8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008900">
        <property type="protein sequence ID" value="VDM27604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFH8"/>
    <dbReference type="OrthoDB" id="6278808at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM27604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="186" mass="21157" checksum="797400F200CDA056" modified="2019-02-13" version="1" fragment="single">MMKLKCFRFTYFDLLVVFVIFDLEISLLLNMPTQGLMYWSFIGLLIRVKFLEPYYKVIPLDCYNFLVTNHGIIMIFFFLMPILIGGFVVSMYLGAGIGWTFYPPLSSSLFSESIGVDFLMFSLHLAGASRIFMTNIFSRTSIVLWSYLFTSILLLVTLPVLAAAITMLLFDNKFSSAFFDPLGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FHT8</accession>
    <name>A0A3P7FHT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022162">
        <property type="protein sequence ID" value="VDM35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FHT8"/>
    <dbReference type="OrthoDB" id="6270666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="138" mass="15301" checksum="7923B3644E43C4D2" modified="2019-02-13" version="1">MLVCGQAQNAAKVYRSGSGAEFCFIRRLQPYAQRTLTKAQTENAMIYHQKALNTMPQLQLKASFGIATPELPQGLTLTADESWQEAMSGFDPSKVAKWMTQKDYNSNQKEAEKLHSIPETPIYQGDKDPNNASGCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FJP5</accession>
    <name>A0A3P7FJP5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024075">
        <property type="protein sequence ID" value="VDM36420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FJP5"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="211" mass="24249" checksum="F64F2A4789F24149" modified="2019-02-13" version="1">MVDILQVVVRCLLAVASSRGGIAEVEKRKPVAWILYLHFFLVVCEFVAYSLVIYFEASSQKCLSKACFFLRNSCLLGLVLLVVSLIFILTTFDSTGRVWRHHPGLWCMEEGASSRRLNRAQAHRLIARLWRRRIRCLACLRNACRRLDLDTKRSSRDAMLLVSDMVGTRIWLPPTFLRDCYFCDGNHVSGLAVKVGFHYSASLKTRIYMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FU78</accession>
    <name>A0A3P7FU78_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL51</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L51, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL51 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020361">
        <property type="protein sequence ID" value="VDM31667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FU78"/>
    <dbReference type="OrthoDB" id="10059330at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019373">
        <property type="entry name" value="Ribosomal_mL51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10244">
        <property type="entry name" value="MRP-L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="429" mass="48891" checksum="F5E7F2F50406109D" modified="2019-02-13" version="1">MLIKDKIECEAGDRLAVNSQSFNRALMDALNRCDELETQLLSFESWIDLPIVNPVDSSSNFDDVSDDAHRLVDILQQVQSALLSAVSKDALRDALPERQSMKALKMEHPSQPQRMPQTLRTLMVPQHFQPQQPEMTELPVTTGSVPPVFMQDEQSAPPISGSPSPLGAPTPALSTPQHSFVPQKSQARRIYGDASSPYSQNQSFVMNRTGSDTNLMGQQQFMQHQEGLNDIRLYFSTVWMPTWSLLRQPTGFFCGRFFATWRDRATAELARTDEARATLVGGTGGGSGVRGPQPYLQPKPCNIRYNPRLYTGGVLPRIEWDDEPVKLPDYEPKDMWAPHRAYFGQNDYIDILGDGKLKPEDFYTGPSWALNAKHEFQRVCRLLYDPAVVAWLEEFEPTRLKDLRKRHKYLFVKMNKRINIKFKRYRDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4S5</accession>
    <name>A0A3P7G4S5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021533">
        <property type="protein sequence ID" value="VDM35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4S5"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="37" mass="4266" checksum="F1DBCCA1377F6116" modified="2019-02-13" version="1">MVEDFRASAISRMNGPSASEEHMAWSRRDREKQRGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6L3</accession>
    <name>A0A3P7G6L3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Essential MCU regulator, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Single-pass membrane protein with aspartate-rich tail 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMDT1/EMRE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000112">
        <property type="protein sequence ID" value="VDM17075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G6L3"/>
    <dbReference type="OrthoDB" id="10039145at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018782">
        <property type="entry name" value="MCU_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10161">
        <property type="entry name" value="DDDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="49" mass="5478" checksum="0015F10954765C71" modified="2019-02-13" version="1">MRARPKTDRYGVWKALGIALPFIGLGGYISMKGAALLEEHDIFVIEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GNG7</accession>
    <name>A0A3P7GNG7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003704">
        <property type="protein sequence ID" value="VDM24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GNG7"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40789" checksum="E2C811D73872EA50" modified="2019-02-13" version="1">MVCSVYGSETGLNFGSWMAYAFPISLIILLCIWFTICLIYLGPKQLFSCRRTKSKSASSEVDEVFTPEGSDAESEYHQSVEDISLADIVNKIIEEEEKVIGTMTWAEGTVLILFVSVVILWIGREPGVPGWSLFMPTKTNSKGRIIHYVGDTQPIVLVAFLALVLPYNNPFKLRIRPDEMRKEALARINRPLLPWTEAEKKCAWGVIILIGGGFALSKIVTSSGLSTVISDGLVGLNVLPPYAIIYILTVMCSFLTEMVSNTATITILTPIMFELADKLAIHPFCLTLPLVLATSLAFILPAATPPNAIIYAKGRVRLFDMVSCAYCASKWGSENALLRIYFLTWAQWKVGSSTVRCGGRIVQPGSSATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HHA2</accession>
    <name>A0A3P7HHA2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020652">
        <property type="protein sequence ID" value="VDM33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HHA2"/>
    <dbReference type="OrthoDB" id="6252992at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="422"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="539" mass="58852" checksum="E48E4E62FA278596" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HNQ0</accession>
    <name>A0A3P7HNQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023539">
        <property type="protein sequence ID" value="VDM36282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="254" mass="27223" checksum="9A14FF71F650C659" modified="2019-02-13" version="1">MSSDYGECLWCLREKLTSPPLRPFPSPSSHPSPSEFGQATNVADASTSASINKSIVLYTPLIIPPFCASSTKPESPAPDLAIAQDDNQVSSDADNSENDNGNTVLLGKAVFPPTTATPSPLPFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPPPHPCEKTIQDLTSKTTVAPFGRLSLRKRRIIRSPFPPQSTRKRHALIKPRPLLLSPPRMPSLVEVESPTNWSLQSPPSISEEIAAPESASGAVDGGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI30</accession>
    <name>A0A0R3WI30_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NYAP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS229</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI30"/>
    <dbReference type="STRING" id="6205.A0A0R3WI30"/>
    <dbReference type="WBParaSite" id="TTAC_0000022801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252197at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33001" checksum="A7918C36800DD18A" modified="2016-01-20" version="1">MMALGHGSSSKKHRKSRREGTSTEESPKPIKSLMQAFWRRHSSSSNNAEKVATSPRTRTLSPSQSPLSRKTSAPAVSSLEQALRIARGLVEDEVGEMGEKSGEGTVYDLTNEPLAYQSPPPGGFLPRIPEHGESNYTAAQMERLKASVVRRPNSRSDRSSFNSAPPGTYWPDGGTPPQPVISHQPQQQSQPQHHSPAFGLVDRLPRIPPLSRPTSSVFFGGARSPVTSFCASPARTASPTPFFQRPLPPPPPLVDRRGDKMSKSFNLGGNSGPMWQAIPPKSPTGEIEVIDTAVYSNVKIPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIN2</accession>
    <name>A0A0R3WIN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS469</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000041">
        <property type="protein sequence ID" value="VDM16494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000046801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000046801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000046801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059035at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132865" evidence="7">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000046801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25173" checksum="A998EC60847F2172" modified="2016-01-20" version="1">MLRSFLWVAVVFFVTNVGGVYEDARCKCVCVDHSVPKVSNESSAEPKRSVYVKSISSDKWYKRLSVMNFSTCPIMLEDKSDLCPYCDCKYQVRNTTTIKVVVILIVVILSTLSLYLVFMLILEPIFASRGRKTPLDSAQPNLFLPPKAIRSVRSYVLPSQRASGFGDLRVEGVSDEEASGSRDVVGRRGANAVVSRAREHQSRWKGRIEAQRERVFNERTILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIQ9</accession>
    <name>A0A0R3WIQ9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS499</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000045">
        <property type="protein sequence ID" value="VDM16537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIQ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WIQ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000049801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000049801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000049801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000049801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66498" checksum="1613D0DA5201C744" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIV2</accession>
    <name>A0A0R3WIV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ufm1-specific protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS557</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000055">
        <property type="protein sequence ID" value="VDM16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIV2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000055601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000055601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000055601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF3">
        <property type="entry name" value="INACTIVE UFM1-SPECIFIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000055601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26125" checksum="600A5DD2BFDB2000" modified="2016-01-20" version="1">MLRITSEDCLSENDREMGTLHTFKGVVEYWHYGSQKVDDRGWGCGYRTLQTIISWFKLNLSLQSTFPDIDDIQLTLIDAGDKPRSFYKSHEWIGSVEAGIVLQNLTNTDYKIVQVPNGKFDKECTMKIRDHFQNIGAPIMMGEPLSECDNSIGGMKDCSSKCILAIREKENCESPSLLILDPHYYATEEEPDLPYLWKEGWLKWWNTEELSETDFYNMCMPMAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJD3</accession>
    <name>A0A0R3WJD3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ENL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS779</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000096">
        <property type="protein sequence ID" value="VDM16980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJD3"/>
    <dbReference type="STRING" id="6205.A0A0R3WJD3"/>
    <dbReference type="WBParaSite" id="TTAC_0000077801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000077801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000077801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053467at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052790">
        <property type="entry name" value="YEATS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827:SF3">
        <property type="entry name" value="AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827">
        <property type="entry name" value="AHD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000077801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="734" mass="82180" checksum="EA37CFB9D0ADCB73" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKA1</accession>
    <name>A0A0R3WKA1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1137</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000192">
        <property type="protein sequence ID" value="VDM17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKA1"/>
    <dbReference type="STRING" id="6205.A0A0R3WKA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000113601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000113601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000113601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000113601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="912" mass="104018" checksum="8F9B93E40E823466" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL89</accession>
    <name>A0A0R3WL89_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1514</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000353">
        <property type="protein sequence ID" value="VDM18132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL89"/>
    <dbReference type="STRING" id="6205.A0A0R3WL89"/>
    <dbReference type="WBParaSite" id="TTAC_0000152701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000152701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000152701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="279"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000152701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="723" mass="76731" checksum="7A12BB335496453B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH7</accession>
    <name>A0A0R3WLH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1602</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000398">
        <property type="protein sequence ID" value="VDM18273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH7"/>
    <dbReference type="WBParaSite" id="TTAC_0000161501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272107at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35254" checksum="9EAB312B5494DB9B" modified="2016-01-20" version="1">MALHQQRQAKCREVRAASMAQHLQQRQQNQQKQPKYSPNDIQMADNIREFYRTPTMLAEDESFNPHGQLQPEHQLREEEHEEEHEQERGGWKAISIEEPSSTSYDMNSLVEEPDVQEPQAQEVKSEMFGEGDKFSHQTPLWLPSEEDRRTPTLPWTSSIDADVLIEVGTASNSGGGRRKSTKKTPAPPPPSMTRSQTHSLTSPNPKNERICPRAPYSSRYFCAILVNYDKYDSECRLAGLSRESVTSLHRAMVQCPKPLSLTSLVDTEFSNYPRTHLHSQSSLLSPIPLLPSLGPALNRAINTALIVTTITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLJ9</accession>
    <name>A0A0R3WLJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1624</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000412">
        <property type="protein sequence ID" value="VDM18303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000163701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000163701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000163701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6308084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000163701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15093" checksum="872A6F981FBACBF4" modified="2016-01-20" version="1">MDPWSYGYSRQGSQAYENAPSKGAQLLVYPSLANPPATPLVTHHKHVKLSTRFKRLLIVATALPLFALILVVCSTLSPQWERLEFAFDRLIQRACSRHTKTTWRLAHVILEEVDVDAQVEVEVEGQGQGQGQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM53</accession>
    <name>A0A0R3WM53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1828</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000539">
        <property type="protein sequence ID" value="VDM18568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM53"/>
    <dbReference type="STRING" id="6205.A0A0R3WM53"/>
    <dbReference type="WBParaSite" id="TTAC_0000184101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000184101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000184101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132927" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000184101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11740" checksum="969C21D13D68C363" modified="2016-01-20" version="1">MRMLLLYLLVLLGINDRFTATQSRDADTIENTEATATDVDEEALSEGNKSEPLYDKTTFDNIKEALKAERGISDVVLAVINTSTVLRCRPDKNFSNSDGQNGVKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMZ2</accession>
    <name>A0A0R3WMZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pkinase_Tyr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2117</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000766">
        <property type="protein sequence ID" value="VDM18957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WMZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000213001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000213001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000213001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000213001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7611" checksum="10E931E15F267457" modified="2016-01-20" version="1">MWEILSFGLKPFHNTSNAEAVAAIGRGERLARPDTCLVSHYRLMLECWMPDPLLRPTFNTLQPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNJ3</accession>
    <name>A0A0R3WNJ3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="6">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2318</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01000958">
        <property type="protein sequence ID" value="VDM19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WNJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000233101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000233101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000233101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000001">
        <property type="entry name" value="Peptide methionine sulfoxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="7">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000233101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15436" checksum="75A9327C1782B3CE" modified="2016-01-20" version="1">MTSRLTNDEWKRRLPSDVYRVTREKGTEEPFSGKYNKHFENGRYKCVCCGALLFESKDKFDSVCGWPSFSRVSGSSPSGDDAGTNVERRSDTSLGLLRVEVVCKLCDAHLGHVFEDGPEPTNLRYCINSASISFEPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNM4</accession>
    <name>A0A0R3WNM4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2349</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000990">
        <property type="protein sequence ID" value="VDM19763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNM4"/>
    <dbReference type="STRING" id="6205.A0A0R3WNM4"/>
    <dbReference type="WBParaSite" id="TTAC_0000236201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000236201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000236201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM19763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000236201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="48859" checksum="6D726AF7978F8E27" modified="2016-01-20" version="1">MEIPKDEDASEVTRGTTLEIFKHLSMTPASKQFRLCRKSDFTLTARYSNPDTLHIKNPLIGVFRITNIVPTPPDVSCLVKIKARVNSNGIFTISSADIMEKVEKEVEVPIEDSKPDTSSVANASGTEMETETHSSEQPPAVGAASGVAEAAVANQSPPKPKTRLEKKIVLRPRGVPVDATTSQLTPDQLLEFTDFQARLNQSDMIERERQDLKNALEAYVYEMRSKLETCLQHYTTETERDSFNKALTDTEDWIYDEGEDAKKSTISKRLKALQQTGDRYCLRFAEADSRRPAIEALANSCEKVKQVVEDYAAGDPQYDHLSKEDMAKVENTLKTMQQRLNAFVEAAKQLHPTSDPTVFVSELYNAQKELESICNPIITRPKPAPPPPKPADNGGSKTVGRATEDGEGNVASPKSGKTPSVPNGGEVPDSTSATTLAGGEDMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP03</accession>
    <name>A0A0R3WP03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001125">
        <property type="protein sequence ID" value="VDM20161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP03"/>
    <dbReference type="WBParaSite" id="TTAC_0000249101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000249101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000249101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000249101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36902" checksum="7A172AF5F83C962B" modified="2016-01-20" version="1">MPVHLAASYYLGCPIASMSSSYYLLSYPSDKPKEIPPPAATAVKFVDLNTDFYRINDEVKPVLIMKVFHPELSVLGTVPAILRPLIALLMEPNLFPTLPARIKVCVSDSESYTSARLRTVIKWVAETNPFRVLQAIMLSIRNSNYLDYISGIVLNFLEDFCPDFVEAFQVLKVLDMGEGVPSPVEWATNIKEDRVKECQTFPTIPLFVQTAAEFLKGTASPHQPVNFLYKWPVALVHLYRSNLLEKLFITPVYSEFGSIFDFANEYLVEFPNVFGPSRILRYGHYCLIKGVEEANGLISKLTGLRPYAIETCYEGHFRYKIYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP47</accession>
    <name>A0A0R3WP47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2522</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001169">
        <property type="protein sequence ID" value="VDM20335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP47"/>
    <dbReference type="STRING" id="6205.A0A0R3WP47"/>
    <dbReference type="WBParaSite" id="TTAC_0000253501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000253501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000253501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF25">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM20335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000253501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21915" checksum="90966C206CFB05AE" modified="2016-01-20" version="1">MSRNAVCSEGHTLGRMSLFVTPLPVVKRLISYIKEGSDKEEKWKEKAVKSLVKRLKKGNQLDELERAIVNQDSSTRCVTIPRSLDGRLQVAQKKGLPHVFYCQLWRWPDLHTQHELRPVENCQYSFQAKRDEVCINPYHYRRIENPSRLLMPSYLRPFFASVRRFCWLPSATMYSHFPDHAWRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPA0</accession>
    <name>A0A0R3WPA0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2575</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001233">
        <property type="protein sequence ID" value="VDM20529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPA0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000259001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000259001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000259001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000259001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24955" checksum="8683DEF20B2F770E" modified="2016-01-20" version="1">MTQSEQSSKSKVPLQPYSGGNPRFFHPSQHRLDPVTSRMLSRHNGEDASRLRKITKPLMEKKRRERINLALESLKRFVAEPILKEGAQKLEKADILDLTVKYVHSCANRNPSPLPPETPWLSFLAGYSACEAILRHLLTATPTTLLQPYPLPPRQTAALLMALDARKVTAASAYLDTLGQESVVAPPPPPPPPPLSFNSDALNQRSQQQHQQQERPPVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN9</accession>
    <name>A0A0R3WPN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2714</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001420">
        <property type="protein sequence ID" value="VDM20970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000272901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
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    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF423">
        <property type="entry name" value="PROTOCADHERIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
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        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="91"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="200"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="334"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM20970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="614" mass="67210" checksum="ABCF547E28335105" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPR5</accession>
    <name>A0A0R3WPR5_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001455">
        <property type="protein sequence ID" value="VDM21045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WPR5"/>
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        <property type="protein sequence ID" value="TTAC_0000275501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000275501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255900at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049043">
        <property type="entry name" value="WHD_RIOX1"/>
    </dbReference>
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        <property type="entry name" value="WHD_RIOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIOX1/NO66-like C-terminal winged helix" evidence="1">
        <location>
            <begin position="250"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000275501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38841" checksum="2890397A5154BE05" modified="2016-01-20" version="1">MPERFNKSFAMHLGYLQEIINGPLYSVITFVNKEFVGPLINPSSCRVSLPGDIFIIVMEGALEINVFSPKSEETGAALKGIFVSDDVVYVPHQFKHRAKLANSETSHAIALSIINRAPALELNLDEPNDKNSSLFRELLLSTHNSPKNMLDILYIDLNAEDGIEFVFRKWLKGIDGVFTNKEMKLINWEANELRKQFMEDTPAAKLHFTEEAGHAALYGPHWDDPNFVDLEADVANIEKAMRFPDPHVEGCVKFGQELGPDTLIRLTRRSVLSLILRSDDDFACLHHSLANGDDVRSENEPRCLRIPSKFLPMIQWLIAIYPKSTMIYNLPGGNVYDQVTCLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPT8</accession>
    <name>A0A0R3WPT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RT_RNaseH_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2763</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001484">
        <property type="protein sequence ID" value="VDM21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPT8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPT8"/>
    <dbReference type="WBParaSite" id="TTAC_0000277801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000277801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000277801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43807at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000277801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40541" checksum="2EBC1B4D3BD344DC" modified="2016-01-20" version="1">MKASLISIDLTQCFAHGISDVALPIIVYAQVNPLHLKFDVDTMIWLNAFFLSLKTNLQSLFDDSDVSVATSETMIPLFCRAEVLMPRVIFPMHPPPSNPDSTSDYPWTGPSALVVQVDTVLLQTIPKPLTTSMAKTLEECLDKLAKQSQPPPTWGCAHTPPDLPLFKKFTELKPPSQALEGEMKGLLVCIHCPSVWAEFLTICEAARRHSTGSPSFKTYRQALLDPSPFTCWVLIPSWPPWYRPPTAPRYPVTWSPNLSRHLTSPPSHPAPISIVIDLDSSVNPLSVYPVSSTSPHSGNKPKPLHFTIGHSGAVFTFRSVKHLRLPDAVDHLVFLYGLFFRLARLKASIGLDCLENMTRQQENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPW1</accession>
    <name>A0A0R3WPW1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2786</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001506">
        <property type="protein sequence ID" value="VDM21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPW1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPW1"/>
    <dbReference type="WBParaSite" id="TTAC_0000280101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000280101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000280101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="202"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000280101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41292" checksum="134E6BD7A353C247" modified="2016-01-20" version="1">MFPHFVALSQHSSSSQRVNEAMDTDADIVTSTTTSRLTDFEQFDERVCDDLTLREEVDYDGDDGGGGSTAGQDDRQDWENLHQTSTRNHPESRDVLGPMSNAKQDLVRRNGARGALASNQSGPSNTPLTTSGISSRKSNVVKEIERIQQRREERRAAQRAAREQPDVDPNSPSYEFLMMIREYQETLDYRPLTITDEIECHQICVCVRKRPMNKKELGRKEIDVITIPNKQQILVHEPKTKVDLTKYLENQSFRFDYAFDENADNALVYRYTAQPLVQSIFEHGMATCFAYGQTGSGKTHTMGGEFHGKGLQDCSNGIYALAAAGFIFTSTLTDVRHIAFIPFGVLITANLHNKFVSASRLYPKHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQM9</accession>
    <name>A0A0R3WQM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3054</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001856">
        <property type="protein sequence ID" value="VDM21841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQM9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000306901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000306901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000306901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000306901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44486" checksum="B71174295C3599CE" modified="2016-01-20" version="1">MSDSVNLTTSASSSDTLETKDATPFVTPPLISGIRYACIPIWSILLCFGIFGNALTVFVLRAKRLQQSSTSFYLTALAITDMLYLLTSLVASIANFIFFFPLELRQLSRTFCVFTPFLSYTLAYISVWLLVTVTVERAVWVVLPFRARHICTKRTAKFVVVLLVFGFTLLDIHFFVTMRYHEVRPKYWACMTTYFSDKVFPFLDLLLVAVLPCTIMLVANCLIGWKLRVMRKFRSGTASGAVSNNNTDQGSGDKREKSINLTRMLVSTNVFFIVSVTPLLIYDVVFFSVDIRAWAEEAEEVRGGMIFAIERLVYTLWYTNFAIHFLLYCLSGPPFRAEVLVLFNRLRDRTRKPARKPTVDHTELKRPETGLTSTINAVSIGDDVYSREELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR80</accession>
    <name>A0A0R3WR80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3254</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002131">
        <property type="protein sequence ID" value="VDM22246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR80"/>
    <dbReference type="STRING" id="6205.A0A0R3WR80"/>
    <dbReference type="WBParaSite" id="TTAC_0000327001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000327001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000327001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000327001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54271" checksum="4F79A09A2B7203B4" modified="2016-01-20" version="1">MHGYDNEERDMHPFMLAMGPDIPHFTDRQHFYQIDLYPYICAMLGLDKPNKIDGLIDRVLPFLKNKPSEEYLQQFRLYASDLPDWRRQLTSGITNYKSSYRLTSFSLQRKMQSLLVLLFLLCGTCYAQKVILVSLDGFRHDYIEYALQNGRNVSAFQKIAKQGFRGMQVQNVMVTLTFPSHFALATGRTVEHHGLVGNTFYDPDLKDYYKYTNSTKNLQPQWFTMNHNEQIWLTNQRNGGKSGVVYWPSSDSRMYGEMEYVNFGLYSSLPSIRFRVDRVMDWITKPDVNLVVMYYNEPDHSGHGHGPDSKEVLDALEVVNDGIAYLLQRIEQSDDFDEPPNIIVTSDHGMTRVSNKKIVNVSEVLSPDEYIFGVDGSPATLGVWPKPYSLTVDQLYDRLKKLPNCDVYRKEDIPDKYHYKNNKRIAPIVVFPHLGWMVQTNASDPYKDTLSKSSIPILTSYFTPFTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB4</accession>
    <name>A0A0R3WRB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002190">
        <property type="protein sequence ID" value="VDM22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000330401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18919" checksum="B2B7FB4C06D48F2C" modified="2016-01-20" version="1">MAEQEEAVPDCSHTIERGSQSVRTPLSTGHEKGAKSSAHGAEPFVISDGYGGGGGGGGGGGGDNKVLPLPINQRHINGCRYDSLRSVLRQSGMAYEGAYGERARMVAKAEKWCMRWRWRERKRTHTTENEVGCAVQSSVVVVNLEHVFGEFHRRLFRWSLKKEIRVRRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRJ2</accession>
    <name>A0A0R3WRJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibrillar collagen NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3368</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="183" mass="19936" checksum="916C2C88ED2F481E" modified="2016-01-20" version="1">MVSSAIADAMRAEFSDLVKVPLTPNSDLSSLSKLWLEHVTLRHSALLGECCAATVVLNSPSTVSNSLVQSARDFGRSWGRLTRLLAEVKFVNEAQLKIDEQKNWKSLASDFTESGLPEPTLAGVLYASLGDIAIISDLYKSLATSLTLQLHAAFERLLQSSDDRNDVRCLIEESVNLLAKEAS</sequence>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS3707</name>
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    <organism evidence="4">
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        </citation>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002899">
        <property type="protein sequence ID" value="VDM23191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSI2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000372201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000372201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000372201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001135">
        <property type="term" value="P:regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="57"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000372201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46032" checksum="E6C6166FF93F7524" modified="2016-01-20" version="1">MEKLFEGESDQFYFTKCGGDLTLWSQRREYRRLRGELCDWGDLKICPRTYWPPIWCRYDDSFVWNHRILQDLVAAALHYLHMEEGLPKFVTASRSLSPVDESAGLEDEMETCEPRRRAPVGAGQPTRLTECLCALESMLPPVINGFVKQHKLALHMWDVDGSISPNTSDPVTLTIISRRSQFRAGCRYRRRGIDEKGYVANYVETEQVLEVPSEVSVHVLSFLQIRGSVPVFWTQTGIKYKPPIQLHKSLSENREAFRLHIERPLRKFDRLVVVNLVETAPGHQESKITEAFVRQLLLFNNPNITYVGFDFHEYCKGFRFGNVSVLLDGVKDIIRDMKYCWLHKDYLICKQEGVFRVNCVDCLDRTNLVQSVFATSVIEIQVMPMFGGPIMFAQICSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSW5</accession>
    <name>A0A0R3WSW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Junctophilin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3841</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003136">
        <property type="protein sequence ID" value="VDM23529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WSW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000385501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000385501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000385501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM23529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000385501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="52680" checksum="25B1ADE929F29139" modified="2016-01-20" version="1">MRQGLGVRKSAPWGLAAEHHSTVRAAQSQSSLPSTHDSDRGGWRGPGSSGGSAGSVDHIHGGRFETFRSGFVLKATSYPPGSTPPPSRSQSATPFRSSSNDRRTSLKQFLLRKLRKPKSTGDLSSVGPHTIGGPGSAGSGRFGGIHGPRAGGSLRSNISGATGNSMFVEHQSRVDSAGIGATDSLDEPLGPNVTETYSGQWNEDRRSGYGVAERSDGLRYEGEWFNNKKDGYGVTYHPDGSREEGRYKENIIVQPLMKRTKLYLLRHSKLKDNVEEAVRKAREAQTARSVAKTAELRAEEAKNISDQARAIATEFASDFIQMGVQWERSNPFAHMITRSGTPSTTAQVASNGVTMRLANTNNLFVNSLEVSGGNRRGSFRSSFKRSTSGTLNESNLDGPKPGEEIKPQEAQGENPIIIAYRLVDLFSGGASRNMGRSSAPIAFWQDFVIKLARQPFEPPSVNRRVIVARKPKRRYEGTAMNKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH6</accession>
    <name>A0A0R3WTH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4052</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003568">
        <property type="protein sequence ID" value="VDM24074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH6"/>
    <dbReference type="STRING" id="6205.A0A0R3WTH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000406601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19126" checksum="52C5D23279DD922F" modified="2016-01-20" version="1">MASFPKPKELGGPSTSRARTGPMSKKTEDNVSKMVRLVKKHNLEPVIVFCFSRKECEIYALKMSECDFISPADKSVVEEVFKNAIGGLSPEDRCLPQVESVLPLLKKGIGIHHGGLLPILKETVEILFGEGLMKCLFATETFAMGLNMPARTVVFTSVRKYDGANYRWVCSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTZ9</accession>
    <name>A0A0R3WTZ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003960">
        <property type="protein sequence ID" value="VDM24472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTZ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WTZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000423901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000423901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000423901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000423901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33303" checksum="8AA86F301C6D4E83" modified="2016-01-20" version="1">MNESPLLRKSAPSELIVFRVKYRTATKNFQMSRTTSMDDIMKRILESFQEPVTDINKFRLGLFSGDSLVDYISDSKRFLLTNDLVELVQAPELSSKDLIALLACICECLCKPERLDEVENLSERLGELLHSMTCCEFSDHFLINGGATVLFEVVTSITRCADMKADLRVQLWRHLLSGLAALINYDSLILETGRGVDIIDYSFEGKGFEWTHVPDEIIGQVESTYLQQLIIIAKQFSDFVREELCELLYKFRLVFDTSTISLPTLRIRIIQVSKLKVTHHTSVEILKEKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV70</accession>
    <name>A0A0R3WV70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004956">
        <property type="protein sequence ID" value="VDM25358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV70"/>
    <dbReference type="STRING" id="6205.A0A0R3WV70"/>
    <dbReference type="WBParaSite" id="TTAC_0000466001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000466001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000466001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000466001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15895" checksum="2CE82C1207DDB13E" modified="2016-01-20" version="1">MEFTQDKSDPGFNKSLESRHLAVPPFTYHCRGKEIELPDKSRAYAVPNGSLSPASMAIVIVHDIFGFAINNTRRFADMLADQTNAHVLLPDFFHGKPWSLDDFPPRHPEAFSEWLEKISCWEDVSAVWHLSFIFCLSISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWB0</accession>
    <name>A0A0R3WWB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5037</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006024">
        <property type="protein sequence ID" value="VDM26121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWB0"/>
    <dbReference type="STRING" id="6205.A0A0R3WWB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000505001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000505001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000505001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133026" evidence="1">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000505001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11337" checksum="B29845EBDC484C55" modified="2016-01-20" version="1">MLAIAFLTFAITVTNALQLNVGVILEDPSPGKEAAFRKAIYLANERLGRSQRSAEQTLFLNLLIKNIEVADTFAAASASWLPLSLRIFVHDFQILLLKHSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWF9</accession>
    <name>A0A0R3WWF9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5084</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006199">
        <property type="protein sequence ID" value="VDM26223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWF9"/>
    <dbReference type="STRING" id="6205.A0A0R3WWF9"/>
    <dbReference type="WBParaSite" id="TTAC_0000509901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000509901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000509901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000509901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25471" checksum="B595B3C5401F117F" modified="2016-01-20" version="1">MDDSRSLYGFFARPGSGPYVVIALCCVANFINAADRVLMPITIISMADEFDWDLHFQGWILSSFSVGYLSSLVAGGSAAKNFGGRRVLTLAVLLWSLSSFLTPFFAASWPLMIFFRFLLGVGEGIGLPTMFHIFSHTVPVEERGRAFSYLIALGSVGQFVAGIISPHMTWPLPFLLFGGFGLLWVVAWVLFTKSFGDFEHLGPSDYLVSTPPVRHLFVSLTHPSLSSITFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWR0</accession>
    <name>A0A0R3WWR0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BLVR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5183</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006501">
        <property type="protein sequence ID" value="VDM26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWR0"/>
    <dbReference type="WBParaSite" id="TTAC_0000520001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000520001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000520001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000520001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13902" checksum="F180CB8F9DB00750" modified="2016-01-20" version="1">MSEISNPPVETKRPPSITASDVVMADSLEKSVEDISEQDHKHKHGKRSKKGHDSAGQSQNLKHKKKQKNKMAEIKVTDQQHVMFLLGEQHAEEEPHQSPAFVELDELYTDPTSANPPEWREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWU1</accession>
    <name>A0A0R3WWU1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">REJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006637">
        <property type="protein sequence ID" value="VDM26494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000523101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000523101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000523101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000523101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9408" checksum="6A29BF97A95AB919" modified="2016-01-20" version="1">MDDLAFVHRMHLASSTSPSSPLFSLTASVSSPSASHRALVCTASLFHFTYSSSSSSSTTTFSPSCAPTSVSTFHRCYLLILLTGQSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX80</accession>
    <name>A0A0R3WX80_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5355</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01007165">
        <property type="protein sequence ID" value="VDM26783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX80"/>
    <dbReference type="STRING" id="6205.A0A0R3WX80"/>
    <dbReference type="WBParaSite" id="TTAC_0000537001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000537001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000537001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM26783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000537001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22279" checksum="FA8C3C24E8A86614" modified="2016-01-20" version="1">MSGFSDLGLCDSLTKCCHSLGWKNPLPIQVSSIPPALKGSDIIGTSETGSGKTAAFLLPIFQHWLNSGRPKGYALILAPTRELALQITETANMIMNNFIDQDGKINNPLNVFQLVGGVSAADQAVALAWCQHHFVVATPGRLAEHIRQSSGFALHHLSTIKHLVLDEVDRMLSLEFADDLDLLLNLYERPLSCGSKDKGATFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXI7</accession>
    <name>A0A0R3WXI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5463</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007638">
        <property type="protein sequence ID" value="VDM27047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXI7"/>
    <dbReference type="WBParaSite" id="TTAC_0000547701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000547701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000547701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000547701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10018" checksum="51FA24F457C48624" modified="2016-01-20" version="1">MVSLPRRSKYETDGLLRTQQFHRAASGTSTARTQTPQCRRASSSTAAAATKSAAERCQRAGCSFACPRFSRLLSLPSRLHSPLLCLYGQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXR4</accession>
    <name>A0A0R3WXR4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5538</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007890">
        <property type="protein sequence ID" value="VDM27180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXR4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000555401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000555401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000555401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000555401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12045" checksum="30AAA5E1C513A4B4" modified="2016-01-20" version="1">MTYRASNQRHHGETTSPSTNLNNAYRIIKEVLKKFRSREAEEKERANLVEQDNLVIEPGKTAFRLRDLYIRPNIVAKRITGVKSFLTCVKITSLLPLKLLLCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYB6</accession>
    <name>A0A0R3WYB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5741</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008829">
        <property type="protein sequence ID" value="VDM27571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000575601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000575601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000575601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804959at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133121" evidence="5">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM27571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000575601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29206" checksum="BBBBCD82B08A7225" modified="2016-01-20" version="1">MFSLLQLLSSLLFFPTRYDYVKIFDGPDGTAQRLGEYCGRKLPHDSYAASGSMHIQFYTDDTISGKGFHAQYQLVPNGAVANQNQLSLSPIVKLPNSPPSFYRSEQPAYRHRRQSVRTPPRARAPFHGSRYISGIHRTSPWVSQKTLYGNYRPPAVETSRQLRVWRVPYRPPQPPTQTVRTRTRIYNPHAGWSANDYRRMHPQLRTDVEYGIHEVGGLISSYLPATTNPRNQQHQREFISPGATVNTSYRRISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYC6</accession>
    <name>A0A0R3WYC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008894">
        <property type="protein sequence ID" value="VDM27603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYC6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYC6"/>
    <dbReference type="WBParaSite" id="TTAC_0000576601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000576601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000576601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000576601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13751" checksum="862ED5711845808A" modified="2016-01-20" version="1">MLLLYPIKINDCSSPYTTGYGGTFCEKVFSLYIASADVHVAVPFPSRGCFYPRGNISLTFSTDQQEGILFFFSEAIDEPLSSHRFLMAQLHQGHVKISFAIDTGGVATAYSVSMVRRILERLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ34</accession>
    <name>A0A0R3WZ34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6009</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01010212">
        <property type="protein sequence ID" value="VDM28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ34"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ34"/>
    <dbReference type="WBParaSite" id="TTAC_0000602401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000602401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000602401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000602401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14758" checksum="2489579E1A8209DE" modified="2016-01-20" version="1">MESSEPEPLQKLRDLVTGSHWRKCCFSGDGEFVCAGSMKQHSIYIWERASGTLFKILHGQKGETLLDVVWHPLRPIVVSVSNSITKEQISIWAQTQVVNEIALPTFSLDLLLICRIPLFSSFAVVVMSSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N9</accession>
    <name>A0A0R3X0N9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6699</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0N9"/>
    <dbReference type="STRING" id="6205.A0A0R3X0N9"/>
    <dbReference type="WBParaSite" id="TTAC_0000671401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000671401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000671401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000671401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="653" mass="72827" checksum="390CC02AD2598501" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X135</accession>
    <name>A0A0R3X135_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock 70 kDa protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6867</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020327">
        <property type="protein sequence ID" value="VDM31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X135"/>
    <dbReference type="STRING" id="6205.A0A0R3X135"/>
    <dbReference type="WBParaSite" id="TTAC_0000688201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000688201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000688201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF34">
        <property type="entry name" value="CHAPERONE PROTEIN DNAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000688201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="68776" checksum="9ED10C5E2FE2B915" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X192</accession>
    <name>A0A0R3X192_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6938</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020333">
        <property type="protein sequence ID" value="VDM31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X192"/>
    <dbReference type="STRING" id="6205.A0A0R3X192"/>
    <dbReference type="WBParaSite" id="TTAC_0000695301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000695301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000695301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000695301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17712" checksum="C02D6195D60949CE" modified="2016-01-20" version="1">MVLLGIMSRLRWIRQVPSLVSPKTLSVIGTRPMSSLKYTKTHEWIRPEDGTYTIGLSKFATDSIGDVVYVDLPDPGTKLKRGESFGNAESSKATSELFAPISGTVEEINEAVRDKPSLLNKSPENDGWLLKMKPDSSTTSDDLMTGEEYREFLRRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1G4</accession>
    <name>A0A0R3X1G4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ER membrane protein complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7026</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020339">
        <property type="protein sequence ID" value="VDM31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1G4"/>
    <dbReference type="STRING" id="6205.A0A0R3X1G4"/>
    <dbReference type="WBParaSite" id="TTAC_0000704101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000704101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000704101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133144" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17907" checksum="F0363D5FFCA87C90" modified="2016-01-20" version="1">MGNVFLLCAILFVTISANLAFGDSLYIVRAYTNSNSSVLTGSCQALHIIASDGQMSLILNVDVSGSLIALSVVANNQTPYVGICCSTSPAVLSTMVSLRKPSFSVGPDTQEYLAKMDRRREEKLRQDQADNRSFLSKYWMYILPAVFFFILLNSAEQNTGGNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Q5</accession>
    <name>A0A0R3X1Q5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serrate RNA effector molecule homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7147</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Q5"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Q5"/>
    <dbReference type="WBParaSite" id="TTAC_0000716201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000716201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000716201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="6">
        <location>
            <begin position="55"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="5">
        <location>
            <begin position="775"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="869"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="243"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000716201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="986" mass="108676" checksum="11C82624CDCD89AD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1W8</accession>
    <name>A0A0R3X1W8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7220</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020354">
        <property type="protein sequence ID" value="VDM31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1W8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1W8"/>
    <dbReference type="WBParaSite" id="TTAC_0000723501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000723501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000723501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000723501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="514" mass="57836" checksum="E738AFF104AA9481" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Z5</accession>
    <name>A0A0R3X1Z5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7253</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020356">
        <property type="protein sequence ID" value="VDM31604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Z5"/>
    <dbReference type="WBParaSite" id="TTAC_0000726801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000726801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000726801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000726801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="20598" checksum="85D34EFEF971720F" modified="2016-01-20" version="1">MAIYIVALGDRFTHCLEHEAERQNGQVGRGKDPIEMGNQQVVAPASHQLFITSDRDDIGPPNIHSSASSASSASSCTTPLLATTTTTTTASKTVVKTPIPIGTLMRRPAPPPPANTAQGLSLPPPVATAAAMDTAPPPCTLANGMACELMLDDNNEKNLLFHPRERERVESEEKKGPSPACLNCGFDVVDCVANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2H5</accession>
    <name>A0A0R3X2H5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7474</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01020375">
        <property type="protein sequence ID" value="VDM31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2H5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2H5"/>
    <dbReference type="WBParaSite" id="TTAC_0000748901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000748901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000748901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000748901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="36703" checksum="B2AF8B455C03C986" modified="2016-01-20" version="1">MSKPKVGINGFGRIGRLVLRSAICKGTVDVCAINDPFIDLTYMVYMFKYDSTHGPFIGEVKEKDGKLVINGHSISVYKELNAEAIPWDKDGVYYVVESTGVNTDMAKAGAHLKNNRAKKVVISAPSKDAPTFVVGVNLDKYDPSMAIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHSYTATQKLVDGPNPKGWRDGRAGALNIIPAQTGAAKAVTKVIPELQGKLTGMAFRVPTPDVSVVDLTCKLAKPATYEQIKEVVRNASQSPALKGILDYTDEDVVSMDFRTSTASSTFDANAGISLNDTFVKLISWYDNEYGYSCRVIDLITYMYSKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2P1</accession>
    <name>A0A0R3X2P1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7557</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020383">
        <property type="protein sequence ID" value="VDM31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2P1"/>
    <dbReference type="STRING" id="6205.A0A0R3X2P1"/>
    <dbReference type="WBParaSite" id="TTAC_0000757201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000757201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000757201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000757201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39013" checksum="9559158BE346CF05" modified="2016-01-20" version="1">MGGDMKVILVTGGSGLVGQGIRLALETYNLKEPGETWIFASSKDINLCNGTETLSYFANVRPTHVIHLAARVGGLFANMDDNLGFFRTNMQINDNLLEACLKFCVQKTISCLSTCIFPDNTNYPIDETMVHNGPPHFSNYGYAYAKRMIDVLNHAYTEKCGTVYTSIIPTNVFGPYDNFNLEKGHVLPALIHKAYLAKTYFFLATEAGEPLLVLGSGTPLRQFIYSVDLGRLIVWVLRHYNHPEPIILSVPEADEISIKDAASVVASAMGCMGLTFDSSKADGQFKKTASVQKLMSLCPNFQFTPFRKGKSPLCLNSGSLAAAHNHSFNFAHYIPAIMDTCEWFIANFDTCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2V8</accession>
    <name>A0A0R3X2V8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7633</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020389">
        <property type="protein sequence ID" value="VDM32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2V8"/>
    <dbReference type="WBParaSite" id="TTAC_0000764801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000764801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000764801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6245124at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133155" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000764801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9585" checksum="395B27F2AAE69441" modified="2016-01-20" version="1">MLKVLVILSLTLAYHVPSSRAGFFDYYLDYFNLRDKYIPFINDDMDSVNRYKELKKKAREGLALHFEKQREKMEKKYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X362</accession>
    <name>A0A0R3X362_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7749</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020400">
        <property type="protein sequence ID" value="VDM32198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X362"/>
    <dbReference type="STRING" id="6205.A0A0R3X362"/>
    <dbReference type="WBParaSite" id="TTAC_0000776401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000776401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000776401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000776401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10249" checksum="A1B13172423ADECA" modified="2016-01-20" version="1">MTTFRKMDKLTGFSLSYLPKDPGPCYSAEKKWYFNPKSGLCLRFIYGGCGGNGNRFDKKIDCKRMCGVLQLLTTNPACTCCNDVTSKTIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3I3</accession>
    <name>A0A0R3X3I3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7897</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020418">
        <property type="protein sequence ID" value="VDM32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3I3"/>
    <dbReference type="STRING" id="6205.A0A0R3X3I3"/>
    <dbReference type="WBParaSite" id="TTAC_0000791201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000791201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000791201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF388">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000791201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62390" checksum="99D54BEC5C8E9310" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3P2</accession>
    <name>A0A0R3X3P2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7963</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020426">
        <property type="protein sequence ID" value="VDM32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3P2"/>
    <dbReference type="STRING" id="6205.A0A0R3X3P2"/>
    <dbReference type="WBParaSite" id="TTAC_0000797801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000797801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000797801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="11">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="9">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000797801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="31609" checksum="38372C127AA34396" modified="2016-01-20" version="1">MSDLFRGRASTWSAGAPTSDHESDAPRGFDYTDAATATAAAALALRTVTASTSAATTPADQPPNNSNTGGVGGFHYSPSTAADIGSQEFSSRRLVADKTPESTTSDYPQSFFANTASSPSRGSREWNANSGSGSGGGFQSSNFSVLSVAASSPFGHHADGGGGLLTPCGGGYGSSSPYANGSCPQPQQQQQPGLHSGSPSSVGSQLSIPQPSLMSTQGGMAPAATTTGGGGSVPATATTGGGGGSAAKRPARRNPWGSETYSDLIAKAIESYPEKQATLQQIYDYISTNYTYFRERSDPPASAGWKVSTGSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Z2</accession>
    <name>A0A0R3X3Z2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8080</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020443">
        <property type="protein sequence ID" value="VDM32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Z2"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Z2"/>
    <dbReference type="WBParaSite" id="TTAC_0000809501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000809501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000809501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF72">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000809501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30694" checksum="50C57D35E9EDEDC4" modified="2016-01-20" version="1">MDKVTHIPVVELNHLLTCHLCKGYIIDATTVVECLHSFCKTCIINYLDNHNTCPVCDTLLHKTRPQCAIRSDSAMQAIVYKLLPKPGSCKMICHCFSFSLALHPDERGLLSPEKRGDISLNAYVEKEEERVSIELSLWRDRCGPTPPASIQSTTYLLCPPALTVGHLEKLVRLKFDLPSTQHAVEFFFLDNSGVSGGERFTSEFTLSDLVCIYSCTHSWVRAKRNGYAGGEARPMKLFFSVLPISPKALETAEEAITSTSTVATTAATVASNPIALSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X450</accession>
    <name>A0A0R3X450_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8153</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020455">
        <property type="protein sequence ID" value="VDM32658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X450"/>
    <dbReference type="STRING" id="6205.A0A0R3X450"/>
    <dbReference type="WBParaSite" id="TTAC_0000816801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000816801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000816801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM32658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000816801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="580" mass="64009" checksum="7DC4560143C0C39F" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4S9</accession>
    <name>A0A0R3X4S9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020501">
        <property type="protein sequence ID" value="VDM32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4S9"/>
    <dbReference type="STRING" id="6205.A0A0R3X4S9"/>
    <dbReference type="WBParaSite" id="TTAC_0000843201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000843201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000843201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000843201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="10270" checksum="B0B895B21A16FA24" modified="2016-01-20" version="1">MFLPIGYIWIRSRFLQQSKERHQIFILLLTFVVYVLYHASRKPLSVVKTVFHRRCLPTSQKEPNWCQWKPFGMLSLDLFLLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4X8</accession>
    <name>A0A0R3X4X8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8475</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020512">
        <property type="protein sequence ID" value="VDM33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4X8"/>
    <dbReference type="STRING" id="6205.A0A0R3X4X8"/>
    <dbReference type="WBParaSite" id="TTAC_0000849001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000849001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000849001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="256"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000849001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51755" checksum="3D2408D22F0A50DE" modified="2016-01-20" version="1">MSFNDDDMFIDDVELSVAYSSDDNSEPDVDLENQYYNAKSRKDDNPDAAIEEFRKVLAIEAEGGAKGDWGFRALKQMIKLKFRLGRFDEMMEDYRTLLTYIKTAVTRNNSEKSINSILDYVSTSKQMDLLQTFYNTTLNALKDAKNERLWFKTNTKLGKLFLEQGDYVQLQRIIRELRESCQTDEGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLQIKSAIPHPMIMGIIRECGGKMHLRVGEYQRAHTDFFEAFKNYDESGSPRRTQCLKYLVLASMLAKSGINPFDSPETKPYKVDPQIVAVTSLVTAYQNNDVKEFERILREQRESIMSDDFIREHIEDLLHNIRTQVLVKLLRPYTRVRLPFISRQLDLEPREVEALLVACILDGTIAGRIDQASEVLILSPPNPSPVEARYEAINRLASSLSSLMNVIVTRSGTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X543</accession>
    <name>A0A0R3X543_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Negative elongation factor D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8552</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020531">
        <property type="protein sequence ID" value="VDM33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X543"/>
    <dbReference type="STRING" id="6205.A0A0R3X543"/>
    <dbReference type="WBParaSite" id="TTAC_0000856701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000856701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000856701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000856701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="71246" checksum="AB8959DA455BCFCA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X550</accession>
    <name>A0A0R3X550_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8559</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020533">
        <property type="protein sequence ID" value="VDM33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X550"/>
    <dbReference type="STRING" id="6205.A0A0R3X550"/>
    <dbReference type="WBParaSite" id="TTAC_0000857401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000857401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000857401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000857401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12880" checksum="C442B424DFAFCA90" modified="2016-01-20" version="1">MVSVKRMQLVRCLSSLIHGSSASKLMWIFQLYDTEGDGVIDKTEMLKVVQSIYDLLGKHTDPPYEEASVKEHMEFVFSKLDINQDGVISREEFIEACQNDPNISDALGCLHTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5I5</accession>
    <name>A0A0R3X5I5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8714</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020568">
        <property type="protein sequence ID" value="VDM33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5I5"/>
    <dbReference type="STRING" id="6205.A0A0R3X5I5"/>
    <dbReference type="WBParaSite" id="TTAC_0000872901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000872901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000872901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000872901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17548" checksum="1894C53578DAA877" modified="2016-01-20" version="1">MVTFFKRQAEEQTAPVRLLERSFHSCRHCFIEAMNRNRQLSDEDLGVFDEFYDWCMSFPTSQLDLIVYLRCSPEVCADRIRKRDRKGESAISMEYLKQLHDLHEDWLLGSKKDRVGAPVMVFDCDEPLEILRDVYFKHRRQVLCGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5M5</accession>
    <name>A0A0R3X5M5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8765</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020581">
        <property type="protein sequence ID" value="VDM33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5M5"/>
    <dbReference type="STRING" id="6205.A0A0R3X5M5"/>
    <dbReference type="WBParaSite" id="TTAC_0000878001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000878001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000878001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000878001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13564" checksum="A3845CBD7E1C8071" modified="2016-01-20" version="1">MAEKKQDLQDTQRYWVRITLTSVAVKPLEKVAEDVKMRAEDMNLKLKGPIRLPTKTLRITTRKTPCGEGSKTWDRYQMRIHKRILDLYTTSETVQRLTLCDLDPMVRAEVKIEGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5T6</accession>
    <name>A0A0R3X5T6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8834</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020602">
        <property type="protein sequence ID" value="VDM33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5T6"/>
    <dbReference type="WBParaSite" id="TTAC_0000884901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000884901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000884901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260135at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000884901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="789" mass="84574" checksum="10EA1E5F86BBF89A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X601</accession>
    <name>A0A0R3X601_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8904</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020624">
        <property type="protein sequence ID" value="VDM33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000891901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000891901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000891901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000891901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9528" checksum="0A5994F3745F325A" modified="2016-01-20" version="1">MVMLCKGTXXXXGRVEVEIVIACFYLPPGNVAYRFTDNVHPPLADTEASATRPTFNLTSNSSSSLSSLQFCLPYCVSSLHFRSGHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6W0</accession>
    <name>A0A0R3X6W0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020731">
        <property type="protein sequence ID" value="VDM34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000926301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000926301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000926301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6415022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000926301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11220" checksum="ED5D23C23BD6D235" modified="2016-01-20" version="1">MCRLDNLGTGLDNIARRCSLLPVTSSKHEVDGNAFKEALIAARRRSTLASAHGGVSGLRGMDWKAPCEFDLHMLVVGGADHLLRMQTATLRXXXXNTLLDDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X715</accession>
    <name>A0A0R3X715_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytidine deaminase</fullName>
            <ecNumber evidence="4 12">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 12">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9311</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 12">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 12"/>
    <dbReference type="EMBL" id="UYWX01020757">
        <property type="protein sequence ID" value="VDM34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X715"/>
    <dbReference type="STRING" id="6205.A0A0R3X715"/>
    <dbReference type="WBParaSite" id="TTAC_0000932601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14982" checksum="4C682F97C0E5EDE4" modified="2016-01-20" version="1">MASTLTPEMEKVRKASMSVLKNAYCGYSKFSVGAALLDLEGRLFTGVNVENASFPCGWCAEVSAFGAAITAGVKDFAALAVAVAGDKFTPPCGRCRQVISEFCYGKNMPIVLVNGKGEYHLTKIEELLPLAFLSKNMDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X763</accession>
    <name>A0A0R3X763_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9366</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020782">
        <property type="protein sequence ID" value="VDM34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X763"/>
    <dbReference type="WBParaSite" id="TTAC_0000938101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000938101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000938101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10474820at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000938101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12061" checksum="4D366173E67FE33C" modified="2016-01-20" version="1">MHALSRSLPGSCKLLRSKRKIRASFVVNHLALQPSRTATLLGVERCSPNINRCRRILTTLRCPRRCRHCRAPGFVWRVNQILAISQFIIRFVLVILAINRELSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X780</accession>
    <name>A0A0R3X780_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9386</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020792">
        <property type="protein sequence ID" value="VDM34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X780"/>
    <dbReference type="STRING" id="6205.A0A0R3X780"/>
    <dbReference type="WBParaSite" id="TTAC_0000940101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000940101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000940101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6101876at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="13">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000940101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11356" checksum="6E71F493898C0CE6" modified="2016-01-20" version="1">MSGLGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRVVLKVFLEDVIRDAVAYTEHARRKTVTALDVVYALKRHGRTIYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7G5</accession>
    <name>A0A0R3X7G5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Forkhead box protein K1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9475</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020835">
        <property type="protein sequence ID" value="VDM34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7G5"/>
    <dbReference type="STRING" id="6205.A0A0R3X7G5"/>
    <dbReference type="WBParaSite" id="TTAC_0000949001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000949001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000949001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20026">
        <property type="entry name" value="FH_FOXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF6">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="241"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="241"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000949001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50536" checksum="C375884E4357D20B" modified="2016-01-20" version="1">MTRKNSRGSVRTYAVILNGSQRYLMRNRRFVIGRRAGGSDTDIMLDSSLISRRHVEVTWFAGRLLLKCLGKNGITINGHFRRPGSVLYRLPRKCTIRFPNTSIELVVHCQPKRLRVSRRPLKAPHSPENKVAESPQHLSDVEGNDDNHSGRVIPPVSTNRRKQLLTSITINKSLIVDKSLNNSDAGSQQFVDELNHQHQEQHPNRVLQVFGPATSSEPSTGAHLLWDARAHSTYPLIATVKPPYSFAQLIVQALAGQPTRRLTLSGIYQFISQNYPYYRLEDKGWQNSVRHNLSLNKHFFKTPRLPDEPGKGCYWMIDPQFEERFISQAFRRRRYQEEHRTSLREHHLSPSITTYHPLPPVTPQLAVITSSAPSWKSQRSSNSFSVPSIERPVCLSQTPTQCNPVLSAQLVLPPCSRPRTAAKRILVLRHRPVTTIAGSQSSIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7J2</accession>
    <name>A0A0R3X7J2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9502</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020851">
        <property type="protein sequence ID" value="VDM34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7J2"/>
    <dbReference type="WBParaSite" id="TTAC_0000951701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000951701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000951701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000951701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="8021" checksum="3ACA9DE7AF9D7C83" modified="2016-01-20" version="1">MMEEEKEKEKEKEEEKEKEEVKEKEEVKEEEEKEKEEEEVKEEEEKEKEEEEVKEEEEKEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Q5</accession>
    <name>A0A0R3X7Q5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020891">
        <property type="protein sequence ID" value="VDM34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Q5"/>
    <dbReference type="WBParaSite" id="TTAC_0000958001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000958001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000958001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261798at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000958001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22079" checksum="E13CDF3099BA03CA" modified="2016-01-20" version="1">MAVPTANSTAKFCRQLFQDAAPRVMVQQALDQVIRADQERFRAKWNFDVAKGSSTAWRIVHEPKAAFYTKAPRRLKARRRLNQTVLERLQGEISTPNGGLLSDASLIGNLVFDFSGPPVKKKIRSDLIPSSEADPPPVSLATAPCECSTSSIPPTHPISPTADPIFKLPSPILKLLKRKSHPRMTDYFAVHKRAKALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X800</accession>
    <name>A0A0R3X800_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9660</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020963">
        <property type="protein sequence ID" value="VDM34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X800"/>
    <dbReference type="WBParaSite" id="TTAC_0000967501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000967501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000967501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000967501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11791" checksum="4F4011A4FADEA03A" modified="2016-01-20" version="1">MSWLVGTFRTASKAWQRLEKEDDQEEGETAPLSCTDVQGTALAFSRDSMLPPSHPPYSSTKPSELPRRIFHPSMRPPIVVRKDSVCYNTQHREDKVGFRKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8P4</accession>
    <name>A0A0R3X8P4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9904</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01021148">
        <property type="protein sequence ID" value="VDM34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8P4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8P4"/>
    <dbReference type="WBParaSite" id="TTAC_0000991901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000991901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000991901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="218"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000991901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55328" checksum="F64364C79C9C2971" modified="2016-01-20" version="1">MKPFSRIRQRWSEKQGNISEISMPTSVEKLLHVEYDPVTKKFKGMPEAWQELISQSNFTDEEQICHPEEIINACQTHDKFIKQQEHNEKFLGVSGSSLDDLDDSDRKLSDGSGIENGKLEHNSTGSDSSNNPDATSAQTLLAKVMMNSERNKPKVADGLAPTNPLKPSSSIKPSVAQTAVPEKAKDAPLRRKAKKMTDPEFYEALSKIISPGDPLDKYSLETVLGSGASGTVRRARCKATNEPVAIKIMNLSKQPNRDLIISEIQVMEHTRHENIVNYIESFLMRNEDELWVVMEYLDGGPLTDVVTETIMETPLIAAVVKECLKAINFLHEKNIIHRDIKSDNILLGKSGHVKLTDFGFCAQMGSRQSKRQTMVGTPYWMAPEVVNKSVKYGPKIDIWSLGIMIIEMLDGEPPYLNEPPLKAIYLIQTRERPEPKSTEVSPLLRDFLDKCLQVDPEKRATAAELLNHPFLSDTKPLSGLSALIKAARANLSKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9I1</accession>
    <name>A0A0R3X9I1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10191</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021411">
        <property type="protein sequence ID" value="VDM35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001020601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19803" checksum="B362E51D4A8EC4B8" modified="2016-01-20" version="1">MTDQRDWHEGILNEEVSIDEQVEGVGATRKSYSTAMTLFSVHVVHLIAELAERPSTYTQHRHSCPTNTXXXXXXFGQVAPTVSIALNGEVEDLHGGDLLIDSTCKQSPGCETVQCIGPVGSLRASLTEYKYKGGGGGKEGGSESLFEIWGMLSSFSHVDSVVEVLWKEREEGSMEADMVKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAB0</accession>
    <name>A0A0R3XAB0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS10470</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01021736">
        <property type="protein sequence ID" value="VDM35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAB0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAB0"/>
    <dbReference type="WBParaSite" id="TTAC_0001048701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001048701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001048701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="33"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="850"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001048701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="899" mass="97759" checksum="41C00218606E3DEA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCP2</accession>
    <name>A0A0R3XCP2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11301</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023538">
        <property type="protein sequence ID" value="VDM36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCP2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCP2"/>
    <dbReference type="WBParaSite" id="TTAC_0001131901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001131901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001131901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001131901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16836" checksum="1D82D8B2DE68BFC0" modified="2016-01-20" version="1">MDLTLPPFYPVHRWDMAPHIVNAFYNPRENHIYFPAGILQKPFYDAYYPLALNYGGIGVVVGHEIVHAFDRQGSKYDAKGNLRQWWSESTRADFERNSECMVHQYGNYTVQGKNVDGHLTLSENIADNGGIKAAYRLEKVTKRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCZ4</accession>
    <name>A0A0R3XCZ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Skp1_POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11405</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024030">
        <property type="protein sequence ID" value="VDM36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCZ4"/>
    <dbReference type="STRING" id="6205.A0A0R3XCZ4"/>
    <dbReference type="WBParaSite" id="TTAC_0001142101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001142101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001142101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001142101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10826" checksum="E519970CA7F92905" modified="2016-01-20" version="1">MIASLRSNKKQPHHTDSVSVQVPLTPSDVKTVLDALVYGGELEMKQSTEVDTSIEDEKIEDKPITTQSFLYRLAPRTPGFAFLAHIPCTIALASFCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD18</accession>
    <name>A0A0R3XD18_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS11428</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01024140">
        <property type="protein sequence ID" value="VDM36448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD18"/>
    <dbReference type="STRING" id="6205.A0A0R3XD18"/>
    <dbReference type="WBParaSite" id="TTAC_0001144501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001144501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001144501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM36448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001144501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39238" checksum="5157F008D22D304D" modified="2016-01-20" version="1">MHDTELFEVGMPSVKDEADFIKNVCQRFGVTPTDIHDKLTADCVSGRFDSPLCQGVKSLFRFDCLCGSYVSPAHHPNHYLFTKLFAHLIAGPKGIEELTLKNFDYSDRCSLVWIGDYFAYRCRTCGLTPSMSLCGACFTAGNHENHDFNKFKSMCGGACDCGDPSVIRPSGDTVLYALDDEDGDIAQDLVHTTLLESFLFMIVKLRFPESLSTLLIGLLPINDFKVSINLPIFLVLMHHVYPQICAFQRRFIDAYVDHYSRISSTLMITSRVRNISPEAAMQLNNRIVHISVQLFSGVDHAYRMVKEKSLHYLIVKWMRNMFALSRTVNWFATVSSVLLLMRICLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDH1</accession>
    <name>A0A0R3XDH1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11581</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01025281">
        <property type="protein sequence ID" value="VDM37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDH1"/>
    <dbReference type="STRING" id="6205.A0A0R3XDH1"/>
    <dbReference type="WBParaSite" id="TTAC_0001159801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001159801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001159801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001159801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15486" checksum="2663090CE3F3E40E" modified="2016-01-20" version="1">MSNDGLKKTIAAIPLLKTRAGPRDGDDWITRLKEEYTSLIKYVEHNKENDNHWFQIESNANGTRWSGKCWYIHEMRKYEFDVCFDIPVSYPASSPEIMLPELDGKTAKMYRGGKICLTDHFKPLWSRNVPKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD89</accession>
    <name>A0A158RD89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS87</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000006">
        <property type="protein sequence ID" value="VDM15812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD89"/>
    <dbReference type="STRING" id="6205.A0A158RD89"/>
    <dbReference type="ESTHER" id="hydta-a0a158rd89">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000008601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000008601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000008601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043135974" evidence="6">
        <location>
            <begin position="31"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="51"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM15812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000008601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="685" mass="76440" checksum="8B59634E7C4DAF6E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDB3</accession>
    <name>A0A158RDB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS270</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDB3"/>
    <dbReference type="STRING" id="6205.A0A158RDB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000026901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000026901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000026901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="441"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000026901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63449" checksum="5BBEC802811E5736" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REA1</accession>
    <name>A0A158REA1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6937</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020333">
        <property type="protein sequence ID" value="VDM31225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REA1"/>
    <dbReference type="STRING" id="6205.A0A158REA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000695201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000695201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000695201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="275"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000695201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63641" checksum="D25E7220AB9536BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REH6</accession>
    <name>A0A158REH6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7297</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020360">
        <property type="protein sequence ID" value="VDM31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REH6"/>
    <dbReference type="STRING" id="6205.A0A158REH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000731201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000731201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000731201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
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        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
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        <source>
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    <sequence length="226" mass="25470" checksum="938362B7CF368933" modified="2016-06-08" version="1">MFGTRGRKNSVSDRLVPCGPDEIRMEDGTVRIMTETELLDRQIDDATEESLDATRRMMAMCEEAKEAGISTLVMLDDQGEQLDRINEGMDQINEDMKDAEKNLDDLNKCCGLCVLPWNKRKGKSDFAKQLKDEDGFGGGDGPRIIVDQNGMGPTGGYITRITNDAREDEMDQNMQEVAGMIGNLRNMAIDMGSEITQQNTQVERIHLKVRLIIPLPRDLQYLLFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REN5</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="ORF">TTAC_LOCUS7668</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2016-04" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="F:kinesin binding"/>
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        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
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        <property type="entry name" value="JIP3/JIP4"/>
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        <property type="entry name" value="JIP_LZII"/>
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            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32088.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000768301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="63537" checksum="4EAF6314D3B46806" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RER2</accession>
    <name>A0A158RER2_HYDTA</name>
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        <submittedName>
            <fullName evidence="8">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">TTAC_LOCUS7850</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020412">
        <property type="protein sequence ID" value="VDM32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0000786501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000786501"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="GRIP1/2"/>
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        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDUF_B7"/>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="PDZ domain-like"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="70"/>
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        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="818"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="795"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000786501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="948" mass="104039" checksum="F8B24B0BBEE75B46" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RES7</accession>
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        <submittedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TTAC_LOCUS7969</name>
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    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020426">
        <property type="protein sequence ID" value="VDM32447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RES7"/>
    <dbReference type="STRING" id="6205.A0A158RES7"/>
    <dbReference type="WBParaSite" id="TTAC_0000798401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000798401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000798401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047138">
        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031:SF15">
        <property type="entry name" value="LD12055P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
        <property type="entry name" value="RHOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="601"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000798401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="814" mass="90570" checksum="E4FBB2DB6A1B79F2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EB19</accession>
    <name>A0A3P7EB19_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000501">
        <property type="protein sequence ID" value="VDM18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EB19"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="155"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="814"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="890"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="937" mass="103870" checksum="4C567B031FD205BB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EKH8</accession>
    <name>A0A3P7EKH8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAM91 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001128">
        <property type="protein sequence ID" value="VDM20176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EKH8"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="351"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM20176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="89804" checksum="32B9DF0CC6B13611" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EN47</accession>
    <name>A0A3P7EN47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003855">
        <property type="protein sequence ID" value="VDM24371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EN47"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="183" mass="19229" checksum="B21E1204FD3CA82E" modified="2019-02-13" version="1">MYIFPSLCLHVRLDHCLLSIFHSAFVISADVNTVVSHDSREEVGGYNGAYSSVRPLSLRLRIYTVTEGGRQEFRHQLAHCDGGDKGSGGGVGVSGDGDGDNVVRPNYGDSTGVKRTGDDATGVDNVERGMNVAPAHYSSSSSSFGGSSSCVSSAVVVITFLNPMLTDSSPTPLYHPTTSALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXS0</accession>
    <name>A0A3P7EXS0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001622">
        <property type="protein sequence ID" value="VDM21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXS0"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31861" checksum="5AD11F42A1906AC6" modified="2019-02-13" version="1">MDRAERIVLHCLYAIAVAAQTPKILKSIAKIAQGIKPWIVLLRLAINNLIPATCISLRVLLQHPQLRQQFIGFGGLRILFAFVVAETGGSRCEALRTIEACLANSDAVESLLKPLINAPAIVVSFIASMSTEEETQIAALDTIAQMARDENTLAIMSDLDVIEGLARILSVAYSEALKISVVRAIAACSYFGENAEYLGRANCVPMLTAIFRTSTSRARGESDIGAIQLRNAAVRALYGISRLPANVTRIWEADICDELTAMAESTDEQVQEAAAGVITNIRLLERQAACVKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EY85</accession>
    <name>A0A3P7EY85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004475">
        <property type="protein sequence ID" value="VDM24986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EY85"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="91" mass="10637" checksum="470C8C8CC7D2034A" modified="2019-02-13" version="1">MTSSDTPGSERSWQFWLKVFVVLVGMFSVGVFAYVQARYCCDICQRWCRLNRVCVVQEPSKERIAKMRMEQRLPTSRFCVVNEVDTFTAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F4A5</accession>
    <name>A0A3P7F4A5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-related protein Rab-39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F4A5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002456">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25811" checksum="9F3F3AE3639BC417" modified="2019-02-13" version="1">MFESPGLGICSLLLMANPSFSYQFRFILIGDSTVGKSSLLQYFCEGKLSSFAEPTVGVDFSTRNIVLSNGTVIKLRLWDTAGQEKFKSIARSYYRNAVGALLIFDITNHTSFEHVMGWYEDAATNMKCQSPAFLLCGQKSDLENQREVSRMEAEALAQTLGISYIETSALQGQNVEAAFKALTETVYQQMQAGAFRNLGTVSGWDGIKEGYDLPSQASRTRVAMAGERSPPPSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F6J1</accession>
    <name>A0A3P7F6J1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003692">
        <property type="protein sequence ID" value="VDM24209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F6J1"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="285" mass="30350" checksum="EE1A7F1BAFB3BBC7" modified="2019-02-13" version="1">MDDAVDNKEEPQKEAVDEEKKGSISATTSPTTTGPWTTSRWQADDESEKDATTSELNASTKISSVKLALGSSLETMPAVPVSIDMDMSDNESAPKVSTNPPVNESKGGSKAPMPEAPVDSKISAPVLNRPQSRSQERFLHLPPLQVVHLGAPRQTLLAFEPGAGPDHFAEEDQVDAVDEAEVQVVHVLVVAAASVVGVIISVLAPAAVVIAVAVALVVVKAHGVEGRGPTRIDRVVGGTALRIHVDVDARTPRIPVHRAVHTRPCRVIENQWLHHRELACDRSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FIL2</accession>
    <name>A0A3P7FIL2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022422">
        <property type="protein sequence ID" value="VDM35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FIL2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="352" mass="39034" checksum="F48A25C323D66687" modified="2019-02-13" version="1">MVRHTYLFVNRQFRYADKADVIMLIIGAIGSIIVGISFPLNLLIVTEVVNGFVGPDANIEALKTMDEMLKWYILLASITLAVGFAQMFCFSLSSKRQSRRIRLKLFKQMLRQDASWFDRQSMGDLITKMTSQVDQIEAGIGDRLGRFLQNLVLFISCFGSAFQNQWKMALVGLSTTPVIVIAFVILGVGLSRYSTKEEKAYSRANSIASEVLSSIRTVFAFIGQEKESTRYDTNLGAAARVSFKKNIVVGFGNISIPFFLHLWKLFAIFASAGLTFWYGAKLMFNGEPGVDGGKIVSVVLAFLVGSIALGLVLPEFTYFARAVAAAKSTFWVIERASSYHSGSANVSRPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FIV0</accession>
    <name>A0A3P7FIV0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023006">
        <property type="protein sequence ID" value="VDM36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FIV0"/>
    <dbReference type="OrthoDB" id="1063785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="139" mass="15613" checksum="1F8567129FC9A9DC" modified="2019-02-13" version="1">MDEIEDDLKKGEFNWKMAQSDQDYEQIELSLPKFKVEHQINLKPVLSWLGVRRLFDQGSAELAGISSDQRLYAREAKQVAVMEVNEAGVKAAAVSGIAIVPMSLPPPAVAFIVDHPFYCAIYDSYLDMPLFIARVVDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4P6</accession>
    <name>A0A3P7G4P6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023761">
        <property type="protein sequence ID" value="VDM36334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4P6"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="84" mass="9322" checksum="8574A60062585E45" modified="2019-02-13" version="1">MAESCDEVNYTDIIEALCRVHEIPLIKVPDGKQLGEMAGLCKLDRKGCPRKVVSASCIVVKDIGEESRGWKFLVEKHKIPVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G873</accession>
    <name>A0A3P7G873_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024136">
        <property type="protein sequence ID" value="VDM36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G873"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="227" mass="24282" checksum="E67F0D342F30A8E8" modified="2019-02-13" version="1">MPPPCSTSVRLGVWSSTPLPEVASAATDNGDDYGGDDDGGDDNDANISPHLRSTPLSVFSHPSILAVTIRTSRPLDTTTTCNRHDNSHHSNSGVALVTGARASRVGWSTCLPSTLLVSHPCKNAVSGGEAPPPPPPDSSASTLHPPRVTLHSHRVAMKCGFLHAMHTLLHRATLPHSHMGSWMDERADSSGLHRPSLLLIPSNQQTWPMRCPQPASLVLPLEVRRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H911</accession>
    <name>A0A3P7H911_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020351">
        <property type="protein sequence ID" value="VDM31518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H911"/>
    <dbReference type="OrthoDB" id="5947018at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="648" mass="73077" checksum="111656FD13593859" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJZ2</accession>
    <name>A0A3P7HJZ2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021010">
        <property type="protein sequence ID" value="VDM34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJZ2"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017964206" description="Prenyltransferase alpha-alpha toroid domain-containing protein" evidence="8">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="4"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="396" mass="44134" checksum="DDE4379AD9F669D4" modified="2019-02-13" version="1">MHFSLDIFRLTLLHFSVSGLAVLNEPPLTDAQHFINFIYAHQIPSSNVTSILFVTEYNTERCGFRGSSFIGVALNLDANDNWKYSPLPYDSCHVTMNYSALVSLLVLGDDLERVNRQALIDGIKALQSVNGNLVNGSLFCPEFDARFIFSAVASAYILDMLDQLNLDAFEQFLADSITYEGAFGSRPRLEAHAGLTYCSLASLKLMGRLDKVLPPGSPQREKLINWLVERQSGGFNGRCQKEADTCYTFWVGASLRMLGAHQYVNKISLLKFICSTYDPIVGGFMKAPDASNVDLLHSYLALAGLSCLFKNPPPMDSTDPDYVQLTDSFDQLHLDETDINDLVVQLDRLVADDLRPLIPELNLPVDSFQRLMEIHTKWRSSNSTPTTSNHHPPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHX1</accession>
    <name>A0A0R3WHX1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS161</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHX1"/>
    <dbReference type="STRING" id="6205.A0A0R3WHX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000016001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000016001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000016001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM15997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000016001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45836" checksum="DC2DFE07AF1BA579" modified="2016-01-20" version="1">MHPAQRITSQSVRYSCDWDVSAVLSNFQNRNWVEVDPSDHWNIFWASTGSALVIGYLKKINHFSNHYELTRKDLMVKNIKQYRKQLFKAQNPVAAVDEHDFIPTTYLLPQDYTLFTEEFRRNPRATWIIKPSARSRGVGIFIVNRLSQIKKWAREGHTGNRDAFSLPHVAYIENPLLIGGKKFDLRMYVLVTSFKPLKCYVNKLGFCRFCTVRYDRKDSELGNMFVHLTNISIQKHAADYNSRHGGKWSIFNLRLWLEGTRGKEVADKLFNEIYWMMYHSLQSVANVINNDRHCFECYGYDIIIDDTLKPWLIEINASPSLSSTTQLDRIMKYKLVDDVLNIVIPDNQIPDTRISKPTKDLTLGDFEVLYDEQCVQVESSAVLSRTSTTQSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI40</accession>
    <name>A0A0R3WI40_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytoskeleton-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS239</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000016">
        <property type="protein sequence ID" value="VDM16133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WI40"/>
    <dbReference type="WBParaSite" id="TTAC_0000023801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000063">
        <property type="entry name" value="Putative cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="262"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="559"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="826"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1428"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2021"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1434"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2073" mass="227376" checksum="5FB5021787AC1319" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI98</accession>
    <name>A0A0R3WI98_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS310</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000023">
        <property type="protein sequence ID" value="VDM16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI98"/>
    <dbReference type="STRING" id="6205.A0A0R3WI98"/>
    <dbReference type="WBParaSite" id="TTAC_0000030901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000030901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000030901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000067">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="454"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="617"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="726"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="889"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000030901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113768" checksum="761B0D56EB6DA4C1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIG6</accession>
    <name>A0A0R3WIG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS391</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000032">
        <property type="protein sequence ID" value="VDM16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIG6"/>
    <dbReference type="STRING" id="6205.A0A0R3WIG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000039001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000039001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000039001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000039001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="789" mass="86570" checksum="A5CE11F37A6C8C79" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIP0</accession>
    <name>A0A0R3WIP0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS477</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000042">
        <property type="protein sequence ID" value="VDM16504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIP0"/>
    <dbReference type="STRING" id="6205.A0A0R3WIP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000047601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000047601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000047601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000047601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29025" checksum="D0FE05213585227F" modified="2016-01-20" version="1">MAPTKQQSQKGAKKGGKKKTTDPFTKKEWYELRAPSMFSNRTCARTLITRTQGTKIASEGLKGRVIQLSLGDLSDKTQDIFRKFKLQIEDVQGRHCLTNFHGMDLTRDKLCGMVLKWQSTIEAHVDVKTTDGYTLRFFVIAFTKKQEDQKSHAYAQTTRIKKLRAKIVEVVQREVARCDLKSVVQKLIPDSIGQDAMHEASAIFPLSGAFVRKVKVLKKPKLDLARILELHNEGKVNEFGEGVARPAHYEPPVVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJD0</accession>
    <name>A0A0R3WJD0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="2">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS775</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000095">
        <property type="protein sequence ID" value="VDM16975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJD0"/>
    <dbReference type="STRING" id="6205.A0A0R3WJD0"/>
    <dbReference type="WBParaSite" id="TTAC_0000077401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000077401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000077401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000077401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="38676" checksum="15E63828882CB548" modified="2016-01-20" version="1">MPLPRYTIQPTHISRVHMPEKIDNELEYVSNETLCNLMHQMASVASVASEIFEELITDLSAISTRLGRIEERVSSVTATLKSLPTSEEFLSVGLQHLTAPTPGVREQELDSQVLHRSTKPRCMQAQYEAAEPPPPLHVMDALRDDGKTTARFYSDPLFFFDLWRKGMLEDAFDGIGGVGGGGAGGAKGAKKVAKKKRPKPKSKPSSTLGVNDYPPLQQQFLPQQEQKSLQSQPQQQLERQEAQPQQSLPVTLQSSMPSEGSNVAASSEYGEPETLTHPSEWITDAARPTPPFPYYRGGSDGDNIAKSCESPPPPPPPPPPLMDLSISSVGGTSGSACGSGALSVEPIHSLPPYAPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJD6</accession>
    <name>A0A0R3WJD6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS784</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000098">
        <property type="protein sequence ID" value="VDM16987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJD6"/>
    <dbReference type="STRING" id="6205.A0A0R3WJD6"/>
    <dbReference type="WBParaSite" id="TTAC_0000078301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000078301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000078301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000078301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30948" checksum="235B08780E57281E" modified="2016-01-20" version="1">MAELPMSGFLDEAKRLFGTDNLYTLLGCNKSSSQAEIKRAYYRCSLKYHPDRSERSNKTLATAQFQVISKAFSILSNKDAKDAYDETGVIGESFSEKSFEDWLDYFNLIFPRFTEKDIEKQKKKYIGSEEERNDIATYYERYRGSMDKIMESVIFADAFDEDRYRGIIQALIDDKVVKPYDSFVKEPAKKRARRLNRAKKEAAEFQRQANEQKGSEMRGDSMDSLILAIQANKEQRMKAADDLIDNLAAKYCQPPNKKARKSSRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK12</accession>
    <name>A0A0R3WK12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 70 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1039</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000163">
        <property type="protein sequence ID" value="VDM17355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK12"/>
    <dbReference type="STRING" id="6205.A0A0R3WK12"/>
    <dbReference type="WBParaSite" id="TTAC_0000103801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000103801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000103801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064205at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF6">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 152 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="710"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000103801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138878" checksum="488BA5DF1664A6DE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLE8</accession>
    <name>A0A0R3WLE8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1573</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000383">
        <property type="protein sequence ID" value="VDM18231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WLE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000158601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000158601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000158601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000158601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41248" checksum="4AAF08A7C2BDC342" modified="2016-01-20" version="1">MQHHTQNCKKLGTTIRSYPISAGFQGRHTSAIEFKMEFAKLAKRLDQVFKLPLAESWDNVGLLIHPSTSTSVSRICLTNDLTESVLSEVVHTGANFVIAYHPPIFRPLKRLTQGTSKERIVIKCIENKIAVYSPHTALDAVSGGLNDWLLSPFDVLCKIPIKGNNLVSRPPVLTTRHNCKFQEYCIRNNIAPINCDIASSDGRLAEAVVGGDASEFHDAEIGGAITFLPEEGTGRIGLLKEGYTITDVIKSYKTLLNTNILKVALGHGKTFDSPVTAIAVCAGSGGSLFSQEPMAQVADLLVTGEASHHEQLEAVARGATIITAGHSVSERSYLPQCLRPWLEREFAPTHVPIDIATTDVEPGVYVLPSDPTHSFVHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM93</accession>
    <name>A0A0R3WM93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Strawberry notch homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1868</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SBNO family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000567">
        <property type="protein sequence ID" value="VDM18608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WM93"/>
    <dbReference type="WBParaSite" id="TTAC_0000188101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000188101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000188101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000282">
        <property type="entry name" value="Strawberry notch homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="7">
        <location>
            <begin position="222"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="6">
        <location>
            <begin position="897"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="8">
        <location>
            <begin position="1226"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1531"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1642"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1531"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1642"/>
            <end position="1674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000188101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1697" mass="187963" checksum="89534695D4F87459" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN49</accession>
    <name>A0A0R3WN49_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2171</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000820">
        <property type="protein sequence ID" value="VDM19114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN49"/>
    <dbReference type="STRING" id="6205.A0A0R3WN49"/>
    <dbReference type="WBParaSite" id="TTAC_0000218701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000218701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000218701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000218701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28366" checksum="9FB2B831C5A03091" modified="2016-01-20" version="1">MASLVARTLTSSKSAELVLVEGLRCLHVSSVLSAEPLKKKKRVDPQQEQNRIRRKAKRIEREIRRLSKQGKKLKPVEEIEGDRQLMKEESRDRRRPLIVLSEEERDRQILLLKEWARYQARAAKEEEHKLRSVRAAQQRALRSLAAVSPYHLYAAAIQPVGVLTQEGKVVDGETVTPLRLSTSGPFATPPPRDPKSYDAPDGEKIDQTPTFEYEFELDRKFMAEAKRSKFVKIFGKNQAPLQKSNVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP93</accession>
    <name>A0A0R3WP93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2568</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001225">
        <property type="protein sequence ID" value="VDM20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP93"/>
    <dbReference type="STRING" id="6205.A0A0R3WP93"/>
    <dbReference type="WBParaSite" id="TTAC_0000258301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000258301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000258301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000008">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF709">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000258301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34469" checksum="8922E0256C24B28D" modified="2016-01-20" version="1">METMKTKRPWFVRCIKPNPDKKPMTFEDTMVMEQLRYIGILETVRIRSSGFPVRLPYQQFVHNYASLLDRQTFQQVTSIPDLKQRTQSLLNNVNKILVSSSSVKLGQDYEVGRTKVFLRQELADQLESIRRRRHVQAARIIQRAWRRRALGQLDRARNNAATLIQAVFRGYLARKKNQKLLMRIRIPAPENEEEMDYEGNLTAAEIASLPVPQDLAFVIEKVGQSHGKESFFINPEMEVSKTFMVKRLMTSDLPGCWTQFKGDLWTAPTIAQIIANSGSATSKYLDKLMRYLGDRNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPA9</accession>
    <name>A0A0R3WPA9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2584</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001245">
        <property type="protein sequence ID" value="VDM20565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPA9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000259901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000259901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000259901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000259901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26153" checksum="DA446C4BA048D854" modified="2016-01-20" version="1">MGKYVGVDALKTAEGTVEVTQEGEEREEPSQTRPKKINPTDWDAELLVPPHNAQNVREVERLHSQHPAHESSLMIAENRLLCELIPLRAFGDIRYKMPAKVLRSIARLCGLPPSYPVTPRFYISPPYLFATPQVVCHRLNPTRDRFVILASDGLWDMLTPKQAVSVVAQHYLDYHGNPSLAGPRDTAASRLIRTALGGREMDPARIAMHLSVPANVARFYRDDITVQVIYPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPV5</accession>
    <name>A0A0R3WPV5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001500">
        <property type="protein sequence ID" value="VDM21140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPV5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPV5"/>
    <dbReference type="WBParaSite" id="TTAC_0000279501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000279501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000279501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000279501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24420" checksum="F3CA3C41FD5EFA04" modified="2016-01-20" version="1">MSNLKPKDRHLNIADEFTKGDIRSKPDALHRRSLERRHFKHPLVSIVPLISNHLPFHHSDELCLSDPPPVDTVSVYANHLATTHFACVESLEVNHGMSSSLKQLGEDGSAQTSPSQDAPIFAIHSSSYTRTKTPHEVKLPLSPSTSSASKKRNSDDCLSPKSKVSGCSKQNTATNSIIGEGTDGIVAGSATCLLASRRNSKPTVCTADPAVLLKAKGVADEAIKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ86</accession>
    <name>A0A0R3WQ86_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2911</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001666">
        <property type="protein sequence ID" value="VDM21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ86"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ86"/>
    <dbReference type="WBParaSite" id="TTAC_0000292601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000292601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000292601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF10">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000292601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24941" checksum="5D7EA95C9CC755FD" modified="2016-01-20" version="1">MVNSYRLAVTRRELITLTGTNWLNDMIINFYLQMLAHRSRLTVSATSAGALRVATMNSFFYPKLISGPGYAGVRRWTRSINLFEHDIILIPIHDRTIHWCLVAIDLRRRTLSYYDSMGGTNDRCLDVLLNYLNSESEDKLQKPLMAMSTWQKINTGASVPQQRNGSDCGVFLCTYAEFLSRDADFTFSQEDMPDIRKRMMYEILTGQLLTTGTNLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQA0</accession>
    <name>A0A0R3WQA0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2925</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001685">
        <property type="protein sequence ID" value="VDM21526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQA0"/>
    <dbReference type="STRING" id="6205.A0A0R3WQA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000294001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000294001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000294001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281623at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000294001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36622" checksum="BDEB36C543F67132" modified="2016-01-20" version="1">MPWFHDVNWDGNGLPKASTLQTLIDGDAFGLFVSLACELALSDMPQGISEAFACFEIAQETLSQENSSGRKSLNEASNSGFIHCVITPYLLRAFLRWDEVVNEMPFAVTNDDPNHDFKRTISQLIDYLLLLLKTVGLHSAPLEDVASILSLLRQDSMKNKTATLLRTLTSIIRPTKSPVLGQPNGLFSWFEFESPTDSLLIVPSVEADDHSVIDECTSFAGRKRLSEFIPKTLGSDSDQDQAANTDSASLYPGVQGLTFFFWIYFDSLSFQSSSSKPQRGCLLRMLSVAGNGLEIFLSATGELFVATANSGEFYYIPVSNFLSLFHDHRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQI9</accession>
    <name>A0A0R3WQI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3014</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001803">
        <property type="protein sequence ID" value="VDM21745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQI9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQI9"/>
    <dbReference type="WBParaSite" id="TTAC_0000302901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000302901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000302901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000302901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14893" checksum="F88910BB6A06B562" modified="2016-01-20" version="1">MEAVYKSLTKEVEKLQEVEGNIQKRLQTYQQLAGQLSENENVEKDLEVLTEENRVFKLIGPVLVEQSLEEARDTVKKRLKYIQDEMKRNDELMKTMEKERDNHREQITKLQQRFQQEQTRAALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQP0</accession>
    <name>A0A0R3WQP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3065</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001874">
        <property type="protein sequence ID" value="VDM21877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQP0"/>
    <dbReference type="STRING" id="6205.A0A0R3WQP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000308001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000308001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000308001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000308001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40117" checksum="CD3ADCE5E3D50567" modified="2016-01-20" version="1">MGLRDVLTVSPLGLSKTFEFTSREIADSGLTLEDTRALSWDTTTPGRYDISVASNLTVCKSFQTHMLCGGRDVLFSLWDLEKPIVPVFSAKNVRPDTLDLRVPVWVSDVSFVEGYENRLFVTSSRYGDFCVYDVRSGQRRPVCRSAWRVSRKQGKKLVGTGRYPAMLRDLTVTRPITSCVALTSAPGVGLRAVAGNAIGDVCLLDFRMPFSSLVFGSGAEPRRKARSVGARAAAPPVHVRAYHPAAGAISALVCGGAGCANLPHAMPSAVINDQPVVISASVDRFLRVYHRDSGDLLAKIFTKTPVSTFLIRDSAKFPMEASSMPDKEGTAGPDEETDELWVSMEPLESEGEPPMKRRNNKSEVNFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR48</accession>
    <name>A0A0R3WR48_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002089">
        <property type="protein sequence ID" value="VDM22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR48"/>
    <dbReference type="WBParaSite" id="TTAC_0000323801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000323801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000323801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000323801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13007" checksum="3B8FF2C614C05DDB" modified="2016-01-20" version="1">MEKVIDFMKEDEEEGEAYLDAHLIGIATPHGNWGLVGTRAPPFPFAQAHTNYSSPFLIPPPPPPPAQTTSNSSMLHHRRLTSSPPRGAQYGKEVLEGAVESRVRDCLAFPVREVGEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR76</accession>
    <name>A0A0R3WR76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GOLGA2L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3251</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002125">
        <property type="protein sequence ID" value="VDM22238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR76"/>
    <dbReference type="STRING" id="6205.A0A0R3WR76"/>
    <dbReference type="WBParaSite" id="TTAC_0000326601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000326601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000326601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287952at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF14">
        <property type="entry name" value="AT31531P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Liprin-alpha CC2" evidence="4">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000326601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37701" checksum="A041E305612F4AA2" modified="2016-01-20" version="1">MTSINRTLKATPGQTALGSSIQECSQDSSESLKQRITELMAQSCELERKLTTSSRELSRANNQISQLHTELTESENKRTEQEAKIITLDQKCLSAQREIAVAQNQADKLRTELAGRVTQLKQMEEKVSRLQTSLETRENSRGETSSSLTEGNKLEQQEGEYDLPSMTQFQQQIISQRSKISALSLQLSNAQDHIKELTEQLEDGNSELVRAREREKLNEEHNERLSSTVDTLLLEANERLQSHLSERMSALQQKRDLVCEVERLRSALEEAIDAREALAKEATSLRRRLTETAESGTLLSPPLKCQNSPSDGMGNLDTMDALLAVDPSGRMSAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB2</accession>
    <name>A0A0R3WRB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CTNNB1_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3287</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002189">
        <property type="protein sequence ID" value="VDM22321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000330201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="33" mass="3143" checksum="28E1A3559CBB3EE2" modified="2016-01-20" version="1">MPESIGSAGGGTGGASSNGNMDNSQGLEVRASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS31</accession>
    <name>A0A0R3WS31_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS3556</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002632">
        <property type="protein sequence ID" value="VDM22868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS31"/>
    <dbReference type="STRING" id="6205.A0A0R3WS31"/>
    <dbReference type="WBParaSite" id="TTAC_0000357101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000357101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000357101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM22868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000357101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20738" checksum="0B0E7028B4731E29" modified="2016-01-20" version="1">MGALFTRLFDRLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNVNFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERLVEARNELNRMLSEDELRDAVLLVFANKQDLPNACPASEMTQKLGLNSLKNRQWFIQATCATTGTGLYEGLDWMAKALAEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT13</accession>
    <name>A0A0R3WT13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003238">
        <property type="protein sequence ID" value="VDM23686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT13"/>
    <dbReference type="STRING" id="6205.A0A0R3WT13"/>
    <dbReference type="WBParaSite" id="TTAC_0000390301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000390301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000390301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000390301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19391" checksum="D10FAE1D17C2BB17" modified="2016-01-20" version="1">MCATKSAKRAEEDATVKFDCLIQTIEAKKAELISAIKEERDRKLGALKEQIHQCTSKLTRSTGLIQFCIEMLKENDAFSFLLVSQSLINRALHTEQSFLHAIETPPAVVQFCPRTQPTTASGQSHPSTPAHWVKGRSAPLAHSSFVSLMQLDAIHKVISDLSLHEGIGNFNFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTM3</accession>
    <name>A0A0R3WTM3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Paramyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4097</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003652">
        <property type="protein sequence ID" value="VDM24166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTM3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTM3"/>
    <dbReference type="WBParaSite" id="TTAC_0000411301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000411301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000411301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="3">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000411301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33850" checksum="1BD5EB25CB7C212D" modified="2016-01-20" version="1">MRSRPPAVLRMYFEFLIYLRVGTSFHKVQEALAKTSASLTETRTAYEEAQNKLVSLESELQIEHESFASLDERERKLRTDYQAALEEITDLENRENEFKTLIGELETQKKTLSDQVGDISDQLEVEEQHRQKLQLEKGSLEQTLKSLNEEHAALEDKYTKLEKEKKSIESRLTDLSTHLTDEEERSKQLMKLKSKYESSISELEEKLSKEQASRQDLERAKRRLETEVSEKTEQGVDHTRLIDELKQQVANLEAKLSETQQKLDDEVMAKTVTMKQVSLCCVGSYYVLVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTX5</accession>
    <name>A0A0R3WTX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRRcap domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003892">
        <property type="protein sequence ID" value="VDM24411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTX5"/>
    <dbReference type="STRING" id="6205.A0A0R3WTX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000421501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000421501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000421501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF36">
        <property type="entry name" value="CENTRIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000421501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27552" checksum="5F655E360F1C893D" modified="2016-01-20" version="1">MYLTVLNVSGNSIENLEGLKSLTRLKCLNLNQNCISRLNGLENLKNLQRLYLNHNKLHDFPSWFQHNLFSLKCLQVGYNRIDNLHILTKLRRLPNLTELVIRGNPATDPENAHFNSICSSKSSADTDQQESVFKQCCRSFAIFHLRSLTLLDGQVVVPEERKEADSWFEQAEISRINSQLESREAEVAELSDCLARLSIEAEGRGALAEGLAKQKAEQDLRLDEMRKELAAKDELVSKFHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU59</accession>
    <name>A0A0R3WU59_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microtub_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4282</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004071">
        <property type="protein sequence ID" value="VDM24595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU59"/>
    <dbReference type="STRING" id="6205.A0A0R3WU59"/>
    <dbReference type="WBParaSite" id="TTAC_0000429901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000429901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000429901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-associated microtubule-binding" evidence="2">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000429901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="40934" checksum="5A947F43D55C0E7A" modified="2016-01-20" version="1">MRDTEGARVRAEVFEDLTARAIALSSSATAWARLRDVELEENRNMCAELKERRKVEEAETCALIEILQKALSSASVLVKTRAESDAKIDANLAAKLDRMQKIADFEEEALTQASSDLIGCIASAKEAQAAAVASVAPALDDCAVHLSSLSSSIQDAGAALDTLVEYTSQAANECMSSDGGIGKKLVDRSVQWQALGSEVKSLYDGKSTEFFVCAVKDSKTRLNQNKLTVEESLAKVDDAASAVNAYIPELDNISTALVPRLPVLLSEHLSKTVRSYKPTGMTPLRKDVPYPKHLARTAQHSLLLAEFRKAHGFPAHESPLMDVTNRDALSASSCLLLNPSSSSSPTIGCEIENAYVRKSDSRGSSGLGTLSPKSGGFQVIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUK9</accession>
    <name>A0A0R3WUK9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4434</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004411">
        <property type="protein sequence ID" value="VDM24930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUK9"/>
    <dbReference type="WBParaSite" id="TTAC_0000444901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000444901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000444901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10598943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000444901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16556" checksum="381FC8FFC6749860" modified="2016-01-20" version="1">MKEADIPSAQRLIALAPVQKRYNPEPPILQLMLGNHPVKQIKKLSQLPFSPPPLKTWDPALRINFFALLVDTPLILLLITLSFFIPPNRSLSVFGMTVIDAETEVNAVLLVNRIIPPFSSLSFLVCLSNSDPESLILPADETTLMYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUN2</accession>
    <name>A0A0R3WUN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4457</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004489">
        <property type="protein sequence ID" value="VDM24995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WUN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000447201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000447201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000447201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000447201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13330" checksum="ED219CB5D1F9EE86" modified="2016-01-20" version="1">MPAELVNRLARMFQDIKVSHDLTREFQEKASNNNLLGSTEVVSVLVSIKILSSGTWLPRSLPKCAVALPPELEDFIPQSPNYASAFFHNFLPCEFCYPSCSSFRAVHSFPVGSRNLIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUR2</accession>
    <name>A0A0R3WUR2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4487</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004575">
        <property type="protein sequence ID" value="VDM25052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUR2"/>
    <dbReference type="STRING" id="6205.A0A0R3WUR2"/>
    <dbReference type="WBParaSite" id="TTAC_0000450201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000450201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000450201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000450201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21640" checksum="CDEA9B6C1CA4E804" modified="2016-01-20" version="1">MAFSNPEALLASAQQVQQSNAASTTAKSLAKSTKETVTDGDPSRYELIAFISHMGESTAAGHYVCHIKRTALSKGIPGVAPACTPSPCLPDGEKADEWVIFNDEKFPEDSSIMVSREARSALSKAASSFVLCVTSMASIHCEAGKRKTLAASDVIGALRDMQFGHFESPLLQFLESKLVFTFILPVHPDLPTCEPTEMLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV89</accession>
    <name>A0A0R3WV89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4664</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005000">
        <property type="protein sequence ID" value="VDM25398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV89"/>
    <dbReference type="STRING" id="6205.A0A0R3WV89"/>
    <dbReference type="WBParaSite" id="TTAC_0000467901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000467901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000467901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000467901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16048" checksum="7EDB8EE5D0A7AAE4" modified="2016-01-20" version="1">MDSTAYNYSTGIATNNTGGNSISGASSNNRVILNVGGVRHETYKSTLKKIPATRLSRLTEALANYDPLLNEYFFDRHPAVFAQVLNYYRTGKLHYPVDVCGPLFEEELQFWGLDSNQVRRLYILFVLYGLRGAQLEQNNSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV93</accession>
    <name>A0A0R3WV93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005010">
        <property type="protein sequence ID" value="VDM25407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV93"/>
    <dbReference type="WBParaSite" id="TTAC_0000468301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000468301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000468301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000468301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8444" checksum="5FB4E28B3326B175" modified="2016-01-20" version="1">MTSSPRNNNARTVVVVEDGGEVDAGIGAVEHVVTNVVTTKEAVEFGDGPVETVGGTLAGQLVIAHLHGCIVFQQVQRHHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVE8</accession>
    <name>A0A0R3WVE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005177">
        <property type="protein sequence ID" value="VDM25526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000473801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000473801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000473801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000473801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9641" checksum="1FEFACB5FA802CAE" modified="2016-01-20" version="1">MARGVALLFGALLFKFVGLVLVYGVPVPTGVMLPSIMVGFSLLRIYAPNILGLRLRDTTSTSHFLHFPEGRVAFFLGNLMIDCGLLIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVN1</accession>
    <name>A0A0R3WVN1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CACTA en-spm transposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4806</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005397">
        <property type="protein sequence ID" value="VDM25690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVN1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVN1"/>
    <dbReference type="WBParaSite" id="TTAC_0000482101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000482101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000482101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286151at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000482101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14110" checksum="460452DD645D0ABE" modified="2016-01-20" version="1">MVSDNRGYLTPSLSRTQQTSTTAPMDESSETMSYRELQLLEELSSARQELAMLKRASSVIEEPLHKLPPPSTLPTQRRAFQQHHENVEMFSNRHQAHYQSHHDIHQGWVGKMFFFLDRKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVS2</accession>
    <name>A0A0R3WVS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4848</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005477">
        <property type="protein sequence ID" value="VDM25760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVS2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000486201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000486201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000486201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000486201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18928" checksum="F60E50E3CCA90ABC" modified="2016-01-20" version="1">MSKSPDSSPSCFSAEAVASEEEVSEGKLVVNEDWDRWMPDPLEALHHTGPPWKRRIDLLSLLVGIYGSKKSFLVEYRNLLGQRLLRQLNFDTAAQMRHLELLKLRFGEADLQECEVDGLFTSYFWTFQCELDRSLHTILSILNVIYCFGVELFTWREVIIALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVT7</accession>
    <name>A0A0R3WVT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS4862</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005517">
        <property type="protein sequence ID" value="VDM25781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVT7"/>
    <dbReference type="STRING" id="6205.A0A0R3WVT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000487701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000487701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000487701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6156247at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM25781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000487701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16010" checksum="38306CD1C8F17B46" modified="2016-01-20" version="1">MECSKPSNWVWGCGKRFSLDFNLRTHLRIHTGDRPYPCPQPGCSKRFAQSTNLKSHLATHTKLRSPHTSISPTAAAAAAAVASAGNSNGSGVHRMKQASAFLTDHQKHHHQNSHQQHQQHGGYGFYLPAASGTTVSATVAATALSPFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVW8</accession>
    <name>A0A0R3WVW8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4893</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005609">
        <property type="protein sequence ID" value="VDM25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVW8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVW8"/>
    <dbReference type="WBParaSite" id="TTAC_0000490801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000490801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000490801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000024">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000490801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16655" checksum="7092FB43CC378185" modified="2016-01-20" version="1">MREIISIHIGQGGVQTGNACWELYCLEHGIQPDGQMPSEKTIGCGDDSFSTFFLETGAGKHVPRTVMMDLEPTVIDEVRTGTYRQLFHPDQLITGKEDAANNYARGHYTVGKEIVDLVLDRLRKLADQCTGIQGFIIFHSYGGGTGSGFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWU8</accession>
    <name>A0A0R3WWU8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006669">
        <property type="protein sequence ID" value="VDM26518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000523801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000523801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000523801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6308084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000523801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23182" checksum="1E8248EDD3496E80" modified="2016-01-20" version="1">MAQWAYRCPIQGTQFYENCAFKGVQDFVYPSGTKSRTGSVETPHKHVKLSGQFRRLLAIAIALPLLALILVVYSGLSLHWERLEFIFHRIVQQACSSQNNASWQLAHVVMEGTGIPVTKFSKQTQLELCQQWKQAPPTILGVGIYNGSPENATLTEVFNVVGGAFQVCNEIHGKLFNYPVIISLSILISVFVSRTVKWSAHPTASSMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWW6</accession>
    <name>A0A0R3WWW6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS5240</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01006723">
        <property type="protein sequence ID" value="VDM26548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWW6"/>
    <dbReference type="STRING" id="6205.A0A0R3WWW6"/>
    <dbReference type="WBParaSite" id="TTAC_0000525601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000525601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000525601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM26548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000525601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20879" checksum="B234F75DA6B65231" modified="2016-01-20" version="1">MDDANGSSEGKRRRSVLILIPMRLGASDRIEVGHLPTLLRLLEDPACVGLIGGRPRHSVYVAGLQADRLIYLDPHFCQETVDIASLSDDDEFDTSTWHCSTPRVIRAQRLDPSLALGFYCGSREDAVSLLQRLPIISESEISSFSTSSSHHLVDVVTASQVQHLFAPLRFSDDVELDGIYNDGDTCLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX82</accession>
    <name>A0A0R3WX82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5357</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007176">
        <property type="protein sequence ID" value="VDM26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX82"/>
    <dbReference type="WBParaSite" id="TTAC_0000537201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000537201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000537201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276075at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000537201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="18211" checksum="1C5E4A78D142B062" modified="2016-01-20" version="1">MSRVRASVGTSRPLDGVARTPLRIDVEKDGVGGGGDGGGNGGGGGGGGGDGGGGGGGEMGQKEARQCRGLNDGIRWMLESGRLSANSRAARLLHNHLAGKEQPPPPRKSIIRVKWSETVVCHMRVFGCAGAVAFVVLLTHSLPVIVVELCSPCTETSSVSDLEQHATGGSNTLGQCGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXU3</accession>
    <name>A0A0R3WXU3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5568</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008015">
        <property type="protein sequence ID" value="VDM27237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXU3"/>
    <dbReference type="WBParaSite" id="TTAC_0000558301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000558301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000558301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000558301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9739" checksum="FED5E59282470FCD" modified="2016-01-20" version="1">MRHGRGRKSVKREAGEGPGEDENICAVTVPVTITAICERIAITPLTLYNVISFAASLHQRPPDNQSLSSIQTPGTIAGYNYLSASNLIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY31</accession>
    <name>A0A0R3WY31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMC_oxred_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008461">
        <property type="protein sequence ID" value="VDM27405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY31"/>
    <dbReference type="WBParaSite" id="TTAC_0000567101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000567101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000567101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000567101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19549" checksum="BDDA4C55149C175E" modified="2016-01-20" version="1">HGRVAVTITPFLTSDANHRLSISDASVSSFENVLLVLRRVLVPHSPPSQQSYSNAVMLEHQASYNTAGANVFTPSKVVPLLVQAHKRTAIGKEEAKSTKHWFDKMTVPCHSWDFGLRVEEKGEIASGETVGMTLSTSSSSPLPRHCPTLHHLPPYPERWLRDNGVVNTHPHTPTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYU6</accession>
    <name>A0A0R3WYU6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5921</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009734">
        <property type="protein sequence ID" value="VDM27971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYU6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYU6"/>
    <dbReference type="WBParaSite" id="TTAC_0000593601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000593601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000593601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000593601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20334" checksum="0BC036BA6C063B12" modified="2016-01-20" version="1">MGEGETADSNRGDFLEWCTHTAVMDGVLSSLKRDIAKTSENGSTEARAPDSLAERINSIQVESSNLKRHLLLFTYPTDIRHSIQRCREATREHDVAAINLEIVSLTSEHVEGLTKKCEDLVKRIQEGQNLIEQLQKKVSGVSPPPELHNANAELLEELKDLYEKNTKILDHVSRFVPYLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZX2</accession>
    <name>A0A0R3WZX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6363</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZX2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000637801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000637801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000637801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14700">
        <property type="entry name" value="bZIP_ATF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051882">
        <property type="entry name" value="ATF_bZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164:SF3">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000637801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="653" mass="71782" checksum="8C7FDEC20B046FEB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X097</accession>
    <name>A0A0R3X097_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X097"/>
    <dbReference type="WBParaSite" id="TTAC_0000653501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000653501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000653501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266139at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000653501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28433" checksum="9924B2CB4831F6C9" modified="2016-01-20" version="1">MLDQNTILEGVHKQFKLIESTRRKWDVTVLRSDKIFTALTYNLMREAASVKSSCQSDEIWSLKLIPQCSTACKVYLAGDPIRAAHLAAARRIEDDFDSLQDLLWNLQECVESVERIVQRLASLHKLKVPLTDASIVLTSPVTSPSRRKVKRGSGRKSEDGRTLLTAEYVPWSMVLEEGEALLHRLHEDLAFRRGLVRALVPTIGSVIAEGFRGPDRGSPQCLCFLWREARQIVKWEHVLDLVEHIHEVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0B5</accession>
    <name>A0A0R3X0B5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0B5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0B5"/>
    <dbReference type="WBParaSite" id="TTAC_0000655601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000655601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000655601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000655601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="57815" checksum="F8528BD825503655" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0I4</accession>
    <name>A0A0R3X0I4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6629</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0I4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0I4"/>
    <dbReference type="WBParaSite" id="TTAC_0000664401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000664401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000664401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000664401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14727" checksum="F9D6A78DD1FB7EEA" modified="2016-01-20" version="1">LISLFSGRTFDYVCRELPKVPHSVPVLVVGNFRDAVTEVRTFIRRMLKVRQSSCAPIRYCETSMKNGFGLMYIHRFLNIPFLHLQYTYLLQALAANRQAFSDISQQLDMAEENRESICSYEKYIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0J0</accession>
    <name>A0A0R3X0J0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6635</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0J0"/>
    <dbReference type="STRING" id="6205.A0A0R3X0J0"/>
    <dbReference type="WBParaSite" id="TTAC_0000665001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000665001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000665001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="637"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000665001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1251" mass="136956" checksum="7E5744FD4F37B512" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0P6</accession>
    <name>A0A0R3X0P6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6708</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="UYWX01020317">
        <property type="protein sequence ID" value="VDM30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0P6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0P6"/>
    <dbReference type="WBParaSite" id="TTAC_0000672301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000672301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000672301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000824">
        <property type="entry name" value="PRK00066.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="159"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000672301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35372" checksum="00D1B4BB74A01188" modified="2016-01-20" version="1">MAEHAILVPLAPHVHSKPKTKVSIIGVGSVGMAIGFSIMTKGLANILALVDFNEDKVKGEVLDMQHGSQFLHTCNVVDYSYTSHSDVVFIAAGARQIVGESRLNLVQRNVDIYKTIVPEVVKYSPDCIIVVVSNPVDILTYVTWKLSGLPRNRVIGSGTILDSARFRHMLGQKLDLAASSIHGYIIGEHGDSSVAVWSRVSVGGVNLSTVYPKFGEDDDPNNFKAVHKDVIDSAYEIIRLKGYTSWAIGLCCANLCGALLSDRNVVIPVTTNVSGLYGIEGDVFLSMPCVVNSSGVTSVVNMTLTDSEKAKLHNSAKTLLETTASIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0P8</accession>
    <name>A0A0R3X0P8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6710</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020317">
        <property type="protein sequence ID" value="VDM30963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0P8"/>
    <dbReference type="WBParaSite" id="TTAC_0000672501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000672501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000672501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246228at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000672501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24215" checksum="A9FFD92B962FEA81" modified="2016-01-20" version="1">MDMFKDIGFNFDNEVLRAVRFMYSDRRSSSSQNNLRVTKKVNLSSTHSVVRVATRLSNRLLSLYERNLIKRILISMHENVNEVTCRRLLLRLVKAPSVPCTPNCSCCQRITTEGFISPSFSNQKYNGDEDIGYPPMGARWVGSTVSDSRHFALPPENGPCPMEVSDKSLSQSLSLDTSPFSDPCPTPPTSLVEPSVNGHHDRLAADDLISSSSSCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0S6</accession>
    <name>A0A0R3X0S6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6743</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020320">
        <property type="protein sequence ID" value="VDM30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0S6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0S6"/>
    <dbReference type="WBParaSite" id="TTAC_0000675801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000675801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000675801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133122" evidence="9">
        <location>
            <begin position="29"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="10">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000675801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="902" mass="101622" checksum="534FA73211F89788" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1T3</accession>
    <name>A0A0R3X1T3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cilia- and flagella-associated protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS7178</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Flagellar protein involved in sperm flagellum axoneme organization and function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CFAP44 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020351">
        <property type="protein sequence ID" value="VDM31516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X1T3"/>
    <dbReference type="WBParaSite" id="TTAC_0000719301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000719301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000719301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935234at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000401">
        <property type="entry name" value="Cilia- and flagella-associated protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1567"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1946"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="927"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1497"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1633"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1757"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1830"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1567"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1585"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM31516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000719301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1967" mass="224533" checksum="71F5F7FBAD99E665" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X376</accession>
    <name>A0A0R3X376_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7766</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020402">
        <property type="protein sequence ID" value="VDM32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X376"/>
    <dbReference type="STRING" id="6205.A0A0R3X376"/>
    <dbReference type="WBParaSite" id="TTAC_0000778101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000778101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000778101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000778101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="642" mass="72421" checksum="0D6765E775436C5B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3J5</accession>
    <name>A0A0R3X3J5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7909</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020420">
        <property type="protein sequence ID" value="VDM32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000792401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000792401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000792401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277701at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000792401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1449" mass="161111" checksum="9818C92CE44407E8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X420</accession>
    <name>A0A0R3X420_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cell division control protein 42 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8112</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020449">
        <property type="protein sequence ID" value="VDM32614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X420"/>
    <dbReference type="STRING" id="6205.A0A0R3X420"/>
    <dbReference type="WBParaSite" id="TTAC_0000812701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000812701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000812701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000812701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21732" checksum="29BDEDEE7678EC9E" modified="2016-01-20" version="1">MTASSRTMKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGDPMVLALFDTAGQEDYDRLRPLSYPQTDIFLLCFSVVNPTSFANVKEKWFNEVKHHAPNTPYLLVGTQIDLRDDTATLDKLTRNRQKPITYEQGEKLAKEIKAHKYVECSALTQCGLKNVFDEAILATLEPPQTKKARCRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X433</accession>
    <name>A0A0R3X433_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF2012 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8133</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020453">
        <property type="protein sequence ID" value="VDM32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X433"/>
    <dbReference type="STRING" id="6205.A0A0R3X433"/>
    <dbReference type="WBParaSite" id="TTAC_0000814801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000814801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000814801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133192" evidence="9">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="10">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000814801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25598" checksum="DB30A15BF8221B97" modified="2016-01-20" version="1">MGLIFLTFSAILQFLLVRGTDIEGTIVAPIDASPNWAVETKVRVDGNRYLGFIKPDGSFIISDVAPGSYLVEFTNPTFLFQPVRVDINSKGKIRARSVNVLRTTAVKAITHPLRITTVGKAMYFQPREQLRTLDLLLNPTVLCMVIPLLFVMLIPKLMDTNDPEFKEMQKNSIFGGRSAETPDISDYLSSMSLFGGSGTKKPPPKKAVTAPVTSTHSAGQESRRSGNPRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X515</accession>
    <name>A0A0R3X515_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8519</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020522">
        <property type="protein sequence ID" value="VDM33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X515"/>
    <dbReference type="STRING" id="6205.A0A0R3X515"/>
    <dbReference type="WBParaSite" id="TTAC_0000853401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000853401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000853401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Nuclear receptor subfamily 2 group E member"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C4"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM33084.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000853401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56904" checksum="CD4DA459B8E8B30E" modified="2016-01-20" version="1">MYANSKNPVGKPSRGDFQQSPNSIGRILYDIPCKVCKDHSSGKHYGIYACDGCAGFFKRSIRRNRQYTCKSRNGQESCCRVDKPHRNQCRACRLKKCLEAGMNRDSVQHERGPRNSTLRRQVALMLQEQVPPKSRQEPPIPPQSLSSSCIPFHVSDWCFPKPFYNLCPGSYALSPPFTESFNIFLRSGLSLPPPNSFVQFQAPPLPPPISSSSRLPHGKAFLSNLLSPLPLPPPSLPQALSKAEAFGIDNLLNESPLVPVTGAEEERTPVFGKIEPRIPPQTSTTPEELSVCVKGILLSTMTWISTIRPDRQLLRMFLQPPVYSAATQLTPREIACLMSITWPKVFILEAIEVFLKGRDGEKLVAFLVRLCNNGNATGFNASERIETLVRALTALQPSADEFSLLKTFCLFSVGSDLANRVEFEHLSSLCVLLHQNLPVYIHTCLPIGLEQKEAFLQCLTLIESLPDVISCLIRGAFLQIFDCSFENLDYMIERMTFAAVEAANQATMKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6A3</accession>
    <name>A0A0R3X6A3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Usp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020655">
        <property type="protein sequence ID" value="VDM33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6A3"/>
    <dbReference type="STRING" id="6205.A0A0R3X6A3"/>
    <dbReference type="WBParaSite" id="TTAC_0000902801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21328" checksum="A3EEE2F6B7EACF8F" modified="2016-01-20" version="1">MPGGDKNRKQAIIVVRLKLDRTSTGDMSVDGSANVIPQRNVLIPIDASPNCEMAFNWYLENLKNDNDLVYFIHVIEPVYSSPAIGLAMESPPIMVDDMTRVMEESIMLGKKLGQKYMKLAKSANLSYKAFLHIDTKPGSAIVRSAAEHKAQLIVIGSRGFGAIRRTLLGSVSDYVVHNSNVPIAVVPPKPKQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7G9</accession>
    <name>A0A0R3X7G9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9479</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020837">
        <property type="protein sequence ID" value="VDM34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7G9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7G9"/>
    <dbReference type="WBParaSite" id="TTAC_0000949401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000949401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000949401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="541"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="665"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000949401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="740" mass="79698" checksum="4EC06529FE66F5FE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7P3</accession>
    <name>A0A0R3X7P3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA/RNA-binding protein KIN17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9553</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020887">
        <property type="protein sequence ID" value="VDM34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7P3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7P3"/>
    <dbReference type="WBParaSite" id="TTAC_0000956801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000956801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000956801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13155">
        <property type="entry name" value="KOW_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000021">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041330">
        <property type="entry name" value="KN17_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041995">
        <property type="entry name" value="KOW_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18131">
        <property type="entry name" value="KN17_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25092">
        <property type="entry name" value="SH3_KIN17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="7">
        <location>
            <begin position="54"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000956801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51361" checksum="919294BCCFB09471" modified="2016-01-20" version="1">MGKEKPGFLTPKAISNRIKSKGLQKLRWYCQMCQKQCRDENGYKCHTNSESHHRQMKIFMENGGKFISGFSSEFLKGYLDIVRRQFGGKRVHANVVYQEYIKDKEHIHMNATRWHSLTGLCLWLGKQGICRVDETEKGWYIEYIDQDPEAESRRASDARLTKTEDEINRQLLAKQIEKASKSLTNETNAKEVKPLIREDCNVPIKLDLQLASTKSKSESQAGDADVQSSAPEETQKLDQVVEPTSSDHVSPSSSDRVLSPKISVTEKLETIGKVQKIINPLLLAEKKAQKSKALSDADKLHHPSATGGKRSNLDELMAEEEMYKEKRNRKDYWMTVGIEVKLTYYKLPKDLLYRHAVIIDMEDDYTALVQVLGSSKAKLKVDQDHVETVIPPVGDPVLVVNGAYRGEVAILKRVDKERFQVDIIIESGLCRGRMVRDVSMEDVCKVCDISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7T1</accession>
    <name>A0A0R3X7T1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS9591</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020908">
        <property type="protein sequence ID" value="VDM34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7T1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7T1"/>
    <dbReference type="WBParaSite" id="TTAC_0000960601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000960601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000960601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="523"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000960601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="65572" checksum="BB8D4994EF4D6CDE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X871</accession>
    <name>A0A0R3X871_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coatomer subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Epsilon-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9731</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021011">
        <property type="protein sequence ID" value="VDM34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X871"/>
    <dbReference type="STRING" id="6205.A0A0R3X871"/>
    <dbReference type="WBParaSite" id="TTAC_0000974601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000974601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000974601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000974601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28480" checksum="637DCCE0121C7824" modified="2016-01-20" version="1">MNIESIIQDARDNFILENFQECLKLLHGISVCIIVPPEFRDRVDLLTFQAYIAQQKYNVVINEVSKSHELPEYRLVLLLAEQLSEVYSKDEVVDKLNAILMEDIPAKDATALTIGATIFMNLDMPEKALKLLHQSSDLVCDAMSVHCLLMMNRVDLAAKVVLRMQTKNEDSMVSQLASAELCLVQGGEKVAEALNIYQELQEKNKPSTLLLNGQAIALIALGRHTEAEPLLRQALDIVGLPSHRLLHPLHLFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8P6</accession>
    <name>A0A0R3X8P6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9906</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021150">
        <property type="protein sequence ID" value="VDM34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8P6"/>
    <dbReference type="STRING" id="6205.A0A0R3X8P6"/>
    <dbReference type="WBParaSite" id="TTAC_0000992101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000992101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000992101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF131">
        <property type="entry name" value="LD05287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="333"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000992101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="50599" checksum="881813032ED1634B" modified="2016-01-20" version="1">MNSSEIGLMPVQHKGESHDLSFVTSKTSAEIRSRDLPSSPSVSSNPSAEAAPSPAAASNGDDQHQRSTEVKFVAAAAAQIKRKRGRPRKYTFDPFPSQVSGAPHTRLGLSSAFPTVEANGLLPSDPNGSGALDQPKKPRLGRPSKTYISASNTTDTSTSMRSVEVKDPPHGSAVGATTSEQTHQQQLHHDLVSNKFHSPTVSTALFPKIISYPSQSPALLNGHTNGVNGTPSSTVNTTAQMVHSSSATLSNAPLKSSAPVLMEYYNGPFINGAIAGPAAALMSPPPPPPIPATQLAAAACSTMEAGLIRRLLPQAEAAVSATRAGGYPGPHAWTAEMVGSFIATLPGCQNLSRTFVENEIDGAALLCLEQHDLMSILKLKLGPAVKIFGAIRTLRQAFLSIPYNDLTADHSSMLATVVSCFPPLTAVSATQTSGSATGSSAAFSINNLAVEEASSAGSPPPSGSVGVVVVNGAGGRGSPSLVVGTAEKPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Z6</accession>
    <name>A0A0R3X8Z6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FIP-RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10006</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021234">
        <property type="protein sequence ID" value="VDM34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Z6"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Z6"/>
    <dbReference type="WBParaSite" id="TTAC_0001002101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001002101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001002101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="9">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001002101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31624" checksum="1306509A75B33CDD" modified="2016-01-20" version="1">MRQMEAKMDSMTSQAAAVSNADGLAGRLREENTRLCASVVMLEERIKEIEARHQRDLESERSHLDALMARSKRTYEAEIENLRARCQKLEADLSEATINLGKTKVELDSARAEGKRTSEALLDAQDKINSLTDQISSRSNAESWELQKAIADRDSALNALKEVNSAVGNGPRGSISMDTVARLEEMQQIIHRLKEDNKNLTKQVRDAQEESWFNNLRDGQKLLYETDSTLEAEMDMLTKEEVVKLLTQEKHTNNQLRAYLNTLLEKIMLNYPELLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X944</accession>
    <name>A0A0R3X944_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10054</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021275">
        <property type="protein sequence ID" value="VDM35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X944"/>
    <dbReference type="WBParaSite" id="TTAC_0001006901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22883" checksum="C2BDE99DA42672C1" modified="2016-01-20" version="1">MKWGRDSREEEEEEEEEENATIDQLQSATRHCVQHPPPSITRLIALRTVMGEGVQEHGTVVRGSSDRSTRNHTCTAATTEYRGEGVINVGEVVCAVMQCVGVINESVWCTSSRLHRTLSHGHVEVCVCRKESRIPHLVIRMLCNRAEAIASVRSCLREHLEVAEPAHCSSPLRQTARQTRLAVNDLTHISTSHTDSKSGAAAIPFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAB3</accession>
    <name>A0A0R3XAB3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Esterase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10473</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01021743">
        <property type="protein sequence ID" value="VDM35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAB3"/>
    <dbReference type="STRING" id="6205.A0A0R3XAB3"/>
    <dbReference type="WBParaSite" id="TTAC_0001049001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001049001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001049001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133252" description="S-formylglutathione hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001049001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23076" checksum="66F7F60411A93E66" modified="2016-01-20" version="1">MPPLLLRLCFVSFYLSGMALEEISSSKCFGGIQKVFKHDSYTVKCPMKLAVYFPPCYSLGQSCPVVFFLQGLTCTEQNFIIKSGAQRYASQLGLILVNPDTSPRGCNIPEEDDDFDFGSGAGFYVNATQDPWCKHYKMYDYVAVELPELIEKNFNIVPGKYGLFGHSMGGHGALMVGLRNADRFVSVSAFSAMCHPSVVPWGIKAFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAP9</accession>
    <name>A0A0R3XAP9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10609</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021934">
        <property type="protein sequence ID" value="VDM35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAP9"/>
    <dbReference type="WBParaSite" id="TTAC_0001062601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001062601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001062601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001062601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43187" checksum="B5AE6AFB6DAFD183" modified="2016-01-20" version="1">MDQNQSSVSSPHMDSTTDSVNSDTTIVPQSQENGNPIGAVPGGSMETTGLTPRPNGHATPAFPAPGPTIVPLGGLDVGQLTAIYQHMVDSVALTNFLVNSSATATVPSNNGHNQFLPPLYPNNTTVTQFQHTESTCPPMLTVPSETSSITTPSPGTVILPSVWQNSPSALNSTPVPSANNNQVAALGAFYEAMRSHPVMMQPAAFPQPPQPPTAYSMDVATQALAYMVAQQNSQLFLQQQQQQQQQQQQQQQFSANLVQNPQFHPNGVVLPTVPGITHNGAVPPPSSLTYPQFGMPNMQNLAQVFAPPVHHRPAGREPMLTGPENSNLFIYHLPQDYGDMDLVSLFSAFGHVISAKVFVDRATNQSKCFGKDLHHRQSTLLHLCLIKLSFFLSVCVCVYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAQ2</accession>
    <name>A0A0R3XAQ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10612</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021938">
        <property type="protein sequence ID" value="VDM35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAQ2"/>
    <dbReference type="STRING" id="6205.A0A0R3XAQ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001062901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001062901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001062901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043073572" evidence="11">
        <location>
            <begin position="18"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="33"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="253"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001062901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58778" checksum="C73C5926488AF907" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAU0</accession>
    <name>A0A0R3XAU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021988">
        <property type="protein sequence ID" value="VDM35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAU0"/>
    <dbReference type="WBParaSite" id="TTAC_0001066701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001066701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001066701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262795at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001066701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24980" checksum="95E2426F1593546F" modified="2016-01-20" version="1">MILFSALFTTATILFDYLLLPYFVIYLRRNLLTSSLNFFPFLDFILFYGTLFASEFLFRTIALEFKGLGSRIMRWSSPSLIGALVIVSTLSFPMPSILCWIGNVTAGAANSLFCFCLFALCGIQGLLKAAHVFLGGLLFTKYCDAVTFMPRSVAQTGELLLGILRCFCAALFFIIGGAVLYHQRFIAALVIVSTIYSLALSTAIVGYARVYAHDKALRIRIEHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB20</accession>
    <name>A0A0R3XB20_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10730</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022144">
        <property type="protein sequence ID" value="VDM35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB20"/>
    <dbReference type="STRING" id="6205.A0A0R3XB20"/>
    <dbReference type="WBParaSite" id="TTAC_0001074701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001074701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001074701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001074701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="604" mass="67429" checksum="77AD4E159EE3621E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBI7</accession>
    <name>A0A0R3XBI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein PXR1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10897</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022466">
        <property type="protein sequence ID" value="VDM35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBI7"/>
    <dbReference type="WBParaSite" id="TTAC_0001091401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001091401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001091401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001091401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="29640" checksum="791563709B994632" modified="2016-01-20" version="1">MHPTQKKVAEEKDKKKKKKKKQSKANDGKVEEEAEAELFEDILKIVRAVCPSYVECAEKCKREQDGGSGGKEKKDKKMKKELKMKKGDNKKEEVIFESILELVRKTCPSYFECMQQCKEGKEEFDSEEEEEEEEEEEKKKKKKDKEEEEKKKKKKEEQEEKKKKNKNKKEEKEEKKKKNKKKGEEEEKKKKKKKKQKKDDDDEEEEEEEDEKKRDKKKKTKKKKKSRSEKRKDKKKEKKKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBJ4</accession>
    <name>A0A0R3XBJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10905</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022480">
        <property type="protein sequence ID" value="VDM35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0001092101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001092101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001092101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272834at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001092101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20860" checksum="E653597F1D51777C" modified="2016-01-20" version="1">MVPPSSRFHASRRRSRSPLGISGRSLRGNHNNVSLRHLRENNIYSEYRPKFRDEPLVNGSRRDFGPRRYGVSQNEGACIQSGPWTGRNRGIQPNRLVSDYPPRRSSTDFDSEPKRNHRHRAISPPPPNSLPDRYSGDFRVANFGRGYYEERSRGRESMVERERRYDPRDEAAIKAPLDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBP5</accession>
    <name>A0A0R3XBP5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10955</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01022604">
        <property type="protein sequence ID" value="VDM35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBP5"/>
    <dbReference type="STRING" id="6205.A0A0R3XBP5"/>
    <dbReference type="WBParaSite" id="TTAC_0001097201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001097201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001097201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001097201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23944" checksum="E49FE18BE41F5AF9" modified="2016-01-20" version="1">MRGENGSGKIAITEKTPLLMALIAFRLLNAMIIRTTFVPDEVWQSVEVAHRWVYGFGALTWEWTPTVAIRSPLYPLFLAGIYKALALSGVDSRAAIVLLPRLFHGLLTGVTDFTIYLMAIQLSGKLSAEWVLLAETTSWFTAYCGPRSLSNSLEWTLHAMAFRYYPWPPRLGLDSASTTAVPFLFHVCLCILLRPTAAVLWVPVCLHYLLRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBT3</accession>
    <name>A0A0R3XBT3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10993</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01022685">
        <property type="protein sequence ID" value="VDM35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBT3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBT3"/>
    <dbReference type="WBParaSite" id="TTAC_0001101001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001101001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001101001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001101001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10723" checksum="9D8C23A207E27FC1" modified="2016-01-20" version="1">MLVRGYTRFAASCVVFLVSAFFHELMVSVPLKMPRMWAFLGMLGQQPYALLVHYYCPKGGKLGNMAMWLTLILGQPLALYMYFHDYYVLRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBX8</accession>
    <name>A0A0R3XBX8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MutS_I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11038</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022782">
        <property type="protein sequence ID" value="VDM36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBX8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBX8"/>
    <dbReference type="WBParaSite" id="TTAC_0001105501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001105501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001105501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS-like N-terminal" evidence="7">
        <location>
            <begin position="194"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001105501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44014" checksum="9A02121B41C2E5A4" modified="2016-01-20" version="1">MQRSILSFFSKVSGEKKESHAVGSSLSSDNVGTSSKTSTNVNADEDSSLRVTRHKKRRLVFDSSDDEKEDSSCDISDLSQKKSIANLYSCPNKRFARDLTNSPKLSSLPAGSKSRSVGHIKKCYSGTPNDTFAMASCFGLGPNDGSRSFAWPHLTYQFLLPDRIKDAFGRCPSHPDYDPRTLFVPEDFIRKQSPALRQWWILKSQNFDTLLFFKMGKFYELYHMDAVIAVEELKLTYMKGEFAHSGFPEIAFQRMADHLLHRGYKVARVEQTETPEAMAKRISGHSGVDKVVRREICQVITPGTWFAPLRNGISSDNALDAPCTTSSQSANYPEMETDLSFNRYLLVLLVGSDSERSETQLGIALLKAATGEIMVSSPPLFCRLFQHLLQFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC91</accession>
    <name>A0A0R3XC91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRICK1 subunit of SCAR/WAVE actin nucleating complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11151</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023071">
        <property type="protein sequence ID" value="VDM36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC91"/>
    <dbReference type="STRING" id="6205.A0A0R3XC91"/>
    <dbReference type="WBParaSite" id="TTAC_0001116801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001116801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001116801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883432at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008064">
        <property type="term" value="P:regulation of actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033378">
        <property type="entry name" value="BRICK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668:SF1">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001116801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9711" checksum="42DBFD3D9BCAC2C4" modified="2016-01-20" version="1">MEPADYPSEVQEDWTNRENIETICTSLKTVVEFLNRFYSSCRIRLAEMDNRLKTLERKMDRLDAHTAYNVTIQEQIRRNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCC5</accession>
    <name>A0A0R3XCC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger CCCH domain-containing protein 15 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11185</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC3H15/TMA46 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023147">
        <property type="protein sequence ID" value="VDM36165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCC5"/>
    <dbReference type="STRING" id="6205.A0A0R3XCC5"/>
    <dbReference type="WBParaSite" id="TTAC_0001120201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001120201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001120201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001120201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37949" checksum="7F097EBFD704EB59" modified="2016-01-20" version="1">MPPKKKGNDGPSKKTLEKEKKKIIEDKTFGLKNKKGAKQQKYVQQVQKQVTYGNKSFRDMEKIQQEKEARKAEKKGGPDELTLLFKPVTELQKISKGADPKSILCIFFKQGTCTKGDKCKFSHDLTIERKAEKKNIYEDERNEMDDWNQEQLEDVITKKHGAHNKGLPPTTIICKYFLDAVEAGKYGWFWNCPNGEGCHYRHCLPPGFVLKKDRKKMEEQKETISLDELIETERRALGMNQTKVTLQTFLAWKKRKRVEKIAAGKEAKEKKKADFAQGRMFGISGREMFEFNPAFVNEGEEIDGDICDSRLREPEEGEVMDSHSFLTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCF2</accession>
    <name>A0A0R3XCF2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11212</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023220">
        <property type="protein sequence ID" value="VDM36192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCF2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCF2"/>
    <dbReference type="WBParaSite" id="TTAC_0001122901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001122901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001122901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar GTP-binding protein 2 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM36192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001122901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29660" checksum="E45B614A3FEF650B" modified="2016-01-20" version="1">MRTKSTIRRLNMYRNFKAKRDKKGHIVRAAPFQSTVASGSVSRVEPNRRWFAFKEAMKIRNPYEIMLRQTRLPISLLDEKKMRKKPDILAAESFAYVFGKKARRKRPRLNCDDLDVSLLLVICFQMTCLKHPPFRLKSLVREAEANRKSYLKEKDGSLQHDNNGVRDLVSDPHFKAGSSKRLWNELFKVIDSSDVVLYVLDARDPMGTRSRYIEQYMKKEKPNKHLIFVINKVDLVPVWITKRWKTILSAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD22</accession>
    <name>A0A0R3XD22_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 5 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11432</name>
        <name evidence="2" type="ORF">TTAC_LOCUS2332</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000970">
        <property type="protein sequence ID" value="VDM19676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UYWX01024157">
        <property type="protein sequence ID" value="VDM36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD22"/>
    <dbReference type="STRING" id="6205.A0A0R3XD22"/>
    <dbReference type="WBParaSite" id="TTAC_0000234501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000234501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000234501"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001144901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001144901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001144901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000234501-mRNA-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001144901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9634" checksum="4963ECAE09028CA3" modified="2016-01-20" version="1">MRLEWMLLDIPKFVPPCPSQYLPKNGVATKRRVTGDCGFGGSLVHGRNRVSASVDGVTGGDGKAVRCHQPNEEEGSNVGVRAPLGESTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD60</accession>
    <name>A0A0R3XD60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RIIa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01024316">
        <property type="protein sequence ID" value="VDM36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD60"/>
    <dbReference type="STRING" id="6205.A0A0R3XD60"/>
    <dbReference type="WBParaSite" id="TTAC_0001148701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001148701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001148701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012105">
        <property type="entry name" value="Sp17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016533">
        <property type="entry name" value="Sp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="4">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001148701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11199" checksum="8619EDCACA568A20" modified="2016-01-20" version="1">MSAPLSNTNLRVPPGFANILWCFAREVLRVQPPDILTFGMEYFDHLLRVRLETGEEDVAKLGAAIDDRYYNNRSYVMSTPGPRSNRDKSQSSYLGGCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD95</accession>
    <name>A0A0R3XD95_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11505</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024577">
        <property type="protein sequence ID" value="VDM36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD95"/>
    <dbReference type="STRING" id="6205.A0A0R3XD95"/>
    <dbReference type="WBParaSite" id="TTAC_0001152201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001152201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001152201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001152201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16369" checksum="4B4744FB4CF6CBCC" modified="2016-01-20" version="1">MRQSTWSRCGELRASSGVCSPLNKRNAQSCENDGGALKYEMRDERIVVVVSRFVELPLFAFFKCASPTKNYLEPNSRKSSKLTQQVLREENENTGDCYSNGEDESGEEPAQSLQLSSTVVQQLVTELEGVESLNAESLLESIRGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDL5</accession>
    <name>A0A158RDL5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS901</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000124">
        <property type="protein sequence ID" value="VDM17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDL5"/>
    <dbReference type="STRING" id="6205.A0A158RDL5"/>
    <dbReference type="WBParaSite" id="TTAC_0000090001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000090001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000090001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MENTAL"/>
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    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
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    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
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        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="32"/>
            <end position="50"/>
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    <feature type="domain" description="MENTAL" evidence="6">
        <location>
            <begin position="25"/>
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    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="262"/>
            <end position="455"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000090001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53798" checksum="2E9350A5EDAFFD46" modified="2016-06-08" version="1">MVAIVSDRVNVAASAIEGLPDEQRTSPVRRTFLLSIFFEFVLILALWLIYIRTLGDFAEQIKDQVVNMRFNTTLFDVQVIAASRLVFLEVAYGACMTCHRWPSALSSQHESIGLCYTNLVLPIVMAWLLTLFLECRVLPRERMANRIVYSYQRMNPDYFSAIEAQSAHFASVRQWAARAATSRGGGSIYESPEGSFINDTESLLCVSKYNSGGANDAPVDVRFLLAFWTMPTASVRRKLANVVAALLTRAESLRQSAWSVFEDEAWIEVALSSSIKSGSSVTSADLRGFSQRVFRLDAILHARVKTIFNDLVHGFEFSPLWNSTIESARCLQKFPHEDLDIVHLVTKEVLGGLIKPRDFVVLRAWGVKGDTCYVASSSVVFPKCPPVETCVRAEQLINAMFLQPSGSVCHFVCITCCDLKNIPSWFSSQLVARGVQASLNSLYQSLQKRAISLSAGVEDFDESIIPRAPPLPTRQRPVLDEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDY7</accession>
    <name>A0A158RDY7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6331</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDY7"/>
    <dbReference type="WBParaSite" id="TTAC_0000634601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000634601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000634601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260541at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
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        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="4">
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            <begin position="626"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1652"/>
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        </location>
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        </location>
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        <location>
            <begin position="1985"/>
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        </location>
    </feature>
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            <begin position="101"/>
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        </location>
    </feature>
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        <location>
            <begin position="981"/>
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        </location>
    </feature>
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        <location>
            <begin position="1126"/>
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        </location>
    </feature>
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        <location>
            <begin position="1142"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1209"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1406"/>
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        <location>
            <begin position="1612"/>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1954"/>
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            <begin position="1985"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000634601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2005" mass="220662" checksum="8DCDECFC163DFA80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REC2</accession>
    <name>A0A158REC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutamate receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7046</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
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            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020341">
        <property type="protein sequence ID" value="VDM31352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000706101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000706101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000706101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9997229at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043135987" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="531"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000706101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1413" mass="160043" checksum="DA3DB1780A0EDDF8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REJ9</accession>
    <name>A0A158REJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS7410</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020370">
        <property type="protein sequence ID" value="VDM31785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000742501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000742501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000742501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000210">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase delta isoform x2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="166"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="267"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="1243"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="1340"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="1517"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="876"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM31785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000742501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1605" mass="177539" checksum="1E1BEF0FC4378284" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF30</accession>
    <name>A0A158RF30_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8676</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020560">
        <property type="protein sequence ID" value="VDM33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF30"/>
    <dbReference type="STRING" id="6205.A0A158RF30"/>
    <dbReference type="WBParaSite" id="TTAC_0000869101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000869101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000869101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000869101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1276" mass="142306" checksum="5400626A7A1D6B9F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF96</accession>
    <name>A0A158RF96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Usp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020742">
        <property type="protein sequence ID" value="VDM34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF96"/>
    <dbReference type="STRING" id="6205.A0A158RF96"/>
    <dbReference type="WBParaSite" id="TTAC_0000928501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000928501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000928501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="141"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="410"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000928501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="62445" checksum="971BEE4B74C9E33A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E5K1</accession>
    <name>A0A3P7E5K1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000281">
        <property type="protein sequence ID" value="VDM17880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E5K1"/>
    <dbReference type="OrthoDB" id="10317952at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018136470" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="90" mass="9956" checksum="4E095640689873D3" modified="2019-02-13" version="1">MKGLLAFLLIVESSATRLAHEGMDSGELHLSDMGGDLFKRGIMKMRIGKRGFDSGYEDLADDSESAYVYIPEGVMRAALKRAGIRRMRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EDK3</accession>
    <name>A0A3P7EDK3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fibronectin type III domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000243">
        <property type="protein sequence ID" value="VDM17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="111"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="415"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="539"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="702"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="802"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1396"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1513"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1612"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1712"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1827"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1936"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2051"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2158"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2266"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2683"/>
            <end position="2786"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2793"/>
            <end position="2892"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="3216"/>
            <end position="3314"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="3325"/>
            <end position="3435"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="3490"/>
            <end position="3593"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="3892"/>
            <end position="3992"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="4003"/>
            <end position="4108"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="4131"/>
            <end position="4232"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="4379"/>
            <end position="4479"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="4599"/>
            <end position="4706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="4834"/>
            <end position="4938"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4965"/>
            <end position="5247"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5346"/>
            <end position="5450"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5459"/>
            <end position="5572"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5584"/>
            <end position="5678"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5703"/>
            <end position="5794"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5804"/>
            <end position="5909"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="5926"/>
            <end position="6021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="5904"/>
            <end position="5934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="5904"/>
            <end position="5915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="6081" mass="678476" checksum="E56FC6EA1E486A45" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EJU0</accession>
    <name>A0A3P7EJU0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Monocyte to macrophage differentiation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000073">
        <property type="protein sequence ID" value="VDM16794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF3">
        <property type="entry name" value="LD03007P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24467" checksum="472539E2276369EA" modified="2019-02-13" version="1">MEGWAYLPTGLEKVANCATHLPFIPVSVYLAVNLINKTRTPTELLVAAVYGIALISLFGASSAYHFCALFPTKSRFHDLLHFFDRLVIFVFIAASYTPWLVLREFEMDIGLLMLKAIWTTALCGAVYQYFCRKKWRLLSLIFYLTIGVLPAISVAYIKDFSGLRIVALGGLTYITGTIFFKMDGVIPMAHAIWHCFVALAAYIHFSAIDRYLYSPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EKN3</accession>
    <name>A0A3P7EKN3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003112">
        <property type="protein sequence ID" value="VDM23481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EKN3"/>
    <dbReference type="OrthoDB" id="10465609at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11635" checksum="667B4A807B61CF2C" modified="2019-02-13" version="1">MRSRGLVCALPTACATMTSAIERGAGIGQKQGDSRMPCLDNAWLSPNLLLPEGEEASEGLKFTGVCAVAIPPRHPLIPLPNFSDGSGCPSDHCPVYFDLAFHDVGCSTPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ESI3</accession>
    <name>A0A3P7ESI3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002631">
        <property type="protein sequence ID" value="VDM22866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ESI3"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF631">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="195" mass="22335" checksum="453561B7B11F3622" modified="2019-02-13" version="1">MFFRYRDLAARNCLVGEAMTVKVADFGLARYMERDVTYRAREGAKFPIKWTAPEGLVYNCFSIKSDVWAFGVLLWEIATYGAAPYPGVELQDVYVLLEKGTRMEAPQGCPDAVYQLMLDCWSWNSEDRPSFKEMYTRLETIRTSSDINEAVEHELQRHRIRMPPAPLPPPPPTTVAALAPRRSSSCDRMDESNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F2D3</accession>
    <name>A0A3P7F2D3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002534">
        <property type="protein sequence ID" value="VDM22749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F2D3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="76" mass="8331" checksum="2F98F61BC29999E7" modified="2019-02-13" version="1">MRWHNSSDKLAVERADLELAKRLQAEEEAAYLKQASESASQSPSCSPSHHRQNGGGYGQTMSSSWVSLCFESICLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F902</accession>
    <name>A0A3P7F902_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004658">
        <property type="protein sequence ID" value="VDM25109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F902"/>
    <dbReference type="OrthoDB" id="6237547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19057" checksum="C3BBDC2E33808C41" modified="2019-02-13" version="1">MWQSDKAVVNLDFMSWSGGVGNGNCLVAFYTAERVGLQWKTVAVVEEDACNSDHAVICEHKVKDCEDPPGGFNSNTMQFSPTRPHPGTTTTVVCKPGFYSRPAEKSSKTAHPHADDKLLIAEFRCIGQRASPGVADPLQYKANFNYNGLPLNECDGKQLFKFDYIGLPGRRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FD24</accession>
    <name>A0A3P7FD24_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020699">
        <property type="protein sequence ID" value="VDM33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FD24"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000131">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein h3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="302"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="534" mass="57273" checksum="40C80648E74F1F4C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FX33</accession>
    <name>A0A3P7FX33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020650">
        <property type="protein sequence ID" value="VDM33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FX33"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="674" mass="73295" checksum="56C461542B59CEFE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4G0</accession>
    <name>A0A3P7G4G0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023462">
        <property type="protein sequence ID" value="VDM36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="EMBL" id="VDM36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="153" mass="17256" checksum="C4B0C317C1A2EF80" modified="2019-02-13" version="1">MKESNFFALSPSFYLVVIICGFIHPRCTETYLVFIEPITDEVDQRIASLVDALEAAKQSKEQAQLATRHALMEEQERSAQYLECLKAAEKSSEVANRRAQIATNEVVNLRNDLNALREDLSKAHEDLATEKLKCSAAVNKIQQVGWLVDWMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HDQ4</accession>
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        <recommendedName>
            <fullName evidence="7">TRPM-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">TTAC_LOCUS8564</name>
    </gene>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="896"/>
            <end position="915"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1122"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1240"/>
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        <location>
            <begin position="246"/>
            <end position="366"/>
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    <feature type="domain" description="TRPM-like" evidence="7">
        <location>
            <begin position="698"/>
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            <begin position="544"/>
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            <begin position="823"/>
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        </location>
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        <location>
            <begin position="827"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1944" mass="220755" checksum="1058F9E4B7C36700" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HGX1</accession>
    <name>A0A3P7HGX1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Voltage-dependent calcium channel alpha-1 subunit IQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS8888</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020617">
        <property type="protein sequence ID" value="VDM33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
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    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="491"/>
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            <begin position="658"/>
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        <location>
            <begin position="1194"/>
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    </feature>
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        <location>
            <begin position="710"/>
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        <location>
            <begin position="755"/>
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        </location>
    </feature>
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        <location>
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            <end position="793"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1223" mass="140727" checksum="54696B4D1FD83C1B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HI56</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SERAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020713">
        <property type="protein sequence ID" value="VDM33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HI56"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="80453" checksum="8C80D9E361A38638" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HNA3</accession>
    <name>A0A3P7HNA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023359">
        <property type="protein sequence ID" value="VDM36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HNA3"/>
    <dbReference type="OrthoDB" id="6278660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="167" mass="18197" checksum="4C23A57E1C9DB96B" modified="2019-02-13" version="1">MGLAGGITTLPSRIPRFTDLGVRPRRWRRRLSSLLSRFSFLLSTHSLTDGAHPSSTVMDPYYSVGCGSNRIRPTPSSLAALRSGDGDFVVDPTLSVFGSSGSRGGSRSGCVGRRNPLVFDVYVVIEEGVNDREILPDYSKSKIPHENTTHGRPSSQALRRNNACCMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHW4</accession>
    <name>A0A0R3WHW4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS154</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHW4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHW4"/>
    <dbReference type="WBParaSite" id="TTAC_0000015301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000015301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000015301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
            <begin position="271"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="4">
        <location>
            <begin position="912"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000015301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134648" checksum="847CC60BEC3D1989" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI66</accession>
    <name>A0A0R3WI66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS275</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI66"/>
    <dbReference type="STRING" id="6205.A0A0R3WI66"/>
    <dbReference type="WBParaSite" id="TTAC_0000027401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000027401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000027401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF21">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="106"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000027401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="895" mass="95468" checksum="15AD47717BC34519" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJU9</accession>
    <name>A0A0R3WJU9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MDS1 and EVI1 complex locus protein EVI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS967</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000144">
        <property type="protein sequence ID" value="VDM17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJU9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJU9"/>
    <dbReference type="WBParaSite" id="TTAC_0000096601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000096601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000096601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000096601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31790" checksum="69ADBCBC83ECF800" modified="2016-01-20" version="1">MCGFIVCRNTDVMINVQSESEGTRATAIIAAATAPITTTTTIYSSGNDSSSLPTATPRCLPLPLDLSKPEGGERLNTCSPCVSIRPTEMTPLALLPAHFRWDGTFRGIPTPAELGKIIAHRSLTLPDLTRLAKSLFPMPPPDSPTLSPSSPKRFHMPIRMSRNCGKQPQPVITGSLTSSSSSPSSSSKRSGERFYCQYCGKMFPRSANLTRHIRTHTGEQPYRCAFCPRCFSISSNLQRHIRNIHQKERPFHCSLCLKKFGQRANLERHIRNHYLLDSTSQHYSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJV9</accession>
    <name>A0A0R3WJV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exocyst subunit Exo70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000147">
        <property type="protein sequence ID" value="VDM17262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJV9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000097701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000097701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000097701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6150088at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000097701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18769" checksum="922D85288774B9B3" modified="2016-01-20" version="1">MLGDRLGRNHVVMDFAKRMFTIHGEVQKVDFISHAGKCVDDICNSLLAAAVTTKLNLSDLCSQPTSTMHDERKETYSLLIKYLGLFSLELTKLGRTEDVRGTINADEAKTMLQMSRRMLPHLQKEVKPPWAPPIVLLKKSVDSLRFCVDYRRLNTLTKDMFALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK96</accession>
    <name>A0A0R3WK96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5734 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000191">
        <property type="protein sequence ID" value="VDM17516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK96"/>
    <dbReference type="WBParaSite" id="TTAC_0000113101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000113101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000113101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10517816at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043792">
        <property type="entry name" value="DUF5734"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19005">
        <property type="entry name" value="DUF5734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5734" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000113101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8501" checksum="042128365F295596" modified="2016-01-20" version="1">MTEYTLTHLRVGKYKKETKMDAQMTKELQKAAKAKPVEEVVKIEPTVIKFKHHAEEIDRSKIAKMQRNKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKA9</accession>
    <name>A0A0R3WKA9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1146</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000195">
        <property type="protein sequence ID" value="VDM17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKA9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000114501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000114501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000114501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000114501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11131" checksum="3387FFC362468C24" modified="2016-01-20" version="1">MSRSDRANKALVQPIVGFRIFKFIFRLLFMKTPVQIWLYEQSNMRIEGRIVGFDEYMNLVLVEACERHMKSGAKKMIGRILLKGETITLIQKLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKY8</accession>
    <name>A0A0R3WKY8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5734 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1402</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000297">
        <property type="protein sequence ID" value="VDM17939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKY8"/>
    <dbReference type="WBParaSite" id="TTAC_0000141501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000141501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000141501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252090at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000141501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52097" checksum="4A55EA260B94D25F" modified="2016-01-20" version="1">MDKPVKPTKKDKEVQIRTPLRFLDHTKVKKNQQLEAILERENSYLHTSTTATYIGKIFKNRIEFAGEKNAKKPPVKRIKFSQVERIIPNDDALCVHVGWRQGKSVSVTSFAFTEEAVYNGFINNLESTRGFAQDSKNQANQSAGTETFYRPTPSSPSPRWENSEKNAEPSIHRRLSEGYTTSYIMWEEPQARTHHDMKSANLHMPINEAPSSFGTSDTEENVKIVGREEEEEEEEQTVTEENMDEVHHCPCCVQRSGINLKLSNQHLKAYAPSTERGQSYTNFPAHLSHNYKCYRPHQARTTSSMSRESTTDFNETLFDTFNDSDSTMLYPIRSRPRSLPPPIQSTRNVARPAAPQQRHQQTHHQQKFVPKVPRSYQHTLTVDSSSSSGYTSATFHEDGLELIVDPTTSGQYIRNQKRFVTGRVHSRNRNEPAYYYRKNPSSLPRIPRVRDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLF5</accession>
    <name>A0A0R3WLF5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-conjugating enzyme E2 J2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1580</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000387">
        <property type="protein sequence ID" value="VDM18243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLF5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLF5"/>
    <dbReference type="WBParaSite" id="TTAC_0000159301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000159301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000159301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM18243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000159301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26525" checksum="5DDB2FB1BE54FAA6" modified="2016-01-20" version="1">MPPTHKGGLSVAVQRLQQDYLRLVRDPVPFVIAHPLHTNIFEWHYLVCGPPDSPYHGGFYHGKLIFPREYPFRPPSIYMITPNGRFACNTRLCLSISDFHPDTWNPAWSVSTILTGLLSFMLEDTPTMGSIATSTYEKHIMARDSAEFNLKDEVFVELFPDVVREIKAKQLLTQASANSHLSSSRGGIPAVADVGNFINSQRGTGGGRGGQLPFVAVFILFGIFAISVKVVMEFLGDSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLJ0</accession>
    <name>A0A0R3WLJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GRIN_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1615</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in neurite outgrowth.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000406">
        <property type="protein sequence ID" value="VDM18289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000162801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000162801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000162801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10049175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026646">
        <property type="entry name" value="GPRIN2-like/GPRIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032745">
        <property type="entry name" value="GRIN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15718">
        <property type="entry name" value="G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15718:SF3">
        <property type="entry name" value="G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15235">
        <property type="entry name" value="GRIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G protein-regulated inducer of neurite outgrowth C-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000162801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44635" checksum="42D23D85685B8C3C" modified="2016-01-20" version="1">MDAIEKSSAPASANCQRNLLKRRSISLNTPVPLTQGELERYGRVGLVKRQVSTDECGRFNEEFQETSSGSSVSTIVLSKLRSFGRQIHRHMIETVNVTNDVSRGIPRSAVGDIYFQSKSPLEVINRKPASRQYRSAKLSLDLEDTWKCMRVIEMSHDLNDNKQSCSVSKLLDAPLFRESPAEDVSVKSKAPTERRLSTSAPHLEAFEQHHRDKQKKQTAPSAEESKKIISRNARPKEVNYDDQGQTWEIYGADQDPNALGQAIESHLEKMIQRKQREQRCFSLGTEIPHQNTCSTKSSSRASHTGEQILQAARRRFRRRAVSSVTSNSTHTANEESPDRETRGRRSRLLSYINRILRRSSTSALSAHRHKLLHQDSIMENKDTPSGMEKAVISAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLL3</accession>
    <name>A0A0R3WLL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1638</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000420">
        <property type="protein sequence ID" value="VDM18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLL3"/>
    <dbReference type="STRING" id="6205.A0A0R3WLL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000165101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000165101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000165101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF636">
        <property type="entry name" value="BILE SALT EXPORT PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="156"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000165101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44568" checksum="D4DD13D79A1E64A6" modified="2016-01-20" version="1">MKNIRSVMNIREVAGSQVVQESLSAEKTVFAFGLEDYFYKKFVSKSDIGTKQRVNDSLLFGLVHGIANALSYFQTAASFYVGAVLMNSHTLDVLAVFRTFSAFNFGAQGLTRVAALTPDFKKAADRIASVFATLDRQTKLDVTEGDYPSEPLSGSIVFKNVYFRYPTRKNVRVLRKFNYTVKAGDSVALVGASGCGKSTILQLVQRLYDVSPHGPGSGIFMDGHDVRTLAPNWIRQQIGIVSQEPNLFDLSIRENIAYGDNSREVPMEEIIEAAKEANVHEFVQNLPEGYDTPVGARGSQLSGGQKQRIAIARALIRKPKLLLLDEATSALDNESERIVQAALDEAMAKGGRTSLVVAHRLTTVENCDVIVVLQEGQECEIGPPDGLMAAKGIYYQLHNVDAAVKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM81</accession>
    <name>A0A0R3WM81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3868 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1856</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000558">
        <property type="protein sequence ID" value="VDM18596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM81"/>
    <dbReference type="STRING" id="6205.A0A0R3WM81"/>
    <dbReference type="WBParaSite" id="TTAC_0000186901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000186901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000186901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000186901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13238" checksum="9F75EC94F1566FB7" modified="2016-01-20" version="1">MHPFHHGRLRAVFRGRLMKSKNYRLSMGSLFHSVTLQPDETITITKYQAKRSQKIENYAIAYRYVLQVPDGLAYYPVEITFMNRLVWAFNWSYLDNLVATQGVNESYEIVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMA1</accession>
    <name>A0A0R3WMA1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1876</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000574">
        <property type="protein sequence ID" value="VDM18616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMA1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000188901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000188901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000188901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="3">
        <location>
            <begin position="102"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000188901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51109" checksum="A5D2193B0A5188CA" modified="2016-01-20" version="1">MFLNDYDDLPLDALKYLTGECNYGGRVTDGNDRRCLVSLLNIFYNHDLVTQDNYSLSPSGLYTVPPEGSYESYLEFIRSLPSRPSPEVYGLHENADITKDNQETTQLFDAILLTLPRESGGGEKSTEATVSDLAIDILNKLPPEDFDLQKVMKLYPVVYTESMNTVLRQELIRFNTLTAVVRSSLQGLLRAIEGLVVMSAELEEVYASMLVGKVPAVWAAKSYPSLKPLGSYVVDLLARLNFFNEWITFDSPPVFWISGFYFTQSFLTGVLQNFARKYTIPIDMVGFDFEMKRIYINSVLEPPATPSPTETTGSDEEATQEQAQPVDRLPITPSAAADGTLQRRNTFHGLTKPDNGAFITGLFMDGARWDSEAGVVAESKPKVLFDAMPVIWLVPKRLEKVVTEAKYSCPVYKTSVRRGVLSTTGHSTNFVLSILLPTEMPETHWINRGVAALCQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMA3</accession>
    <name>A0A0R3WMA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1878</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000577">
        <property type="protein sequence ID" value="VDM18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMA3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000189101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000189101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000189101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000189101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="632" mass="69174" checksum="2D8C974BBD49D542" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMC0</accession>
    <name>A0A0R3WMC0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Neurogenic locus Notch protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TTAC_LOCUS1895</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000589">
        <property type="protein sequence ID" value="VDM18635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WMC0"/>
    <dbReference type="WBParaSite" id="TTAC_0000190801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000190801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000190801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="10 17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="22">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="961"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="1148"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="1181"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="924"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1100"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1240"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1333"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1373"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1333"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1401"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1422"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDM18635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000190801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1516" mass="161351" checksum="2F7424078C320125" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMC9</accession>
    <name>A0A0R3WMC9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1904</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="UYWX01000595">
        <property type="protein sequence ID" value="VDM18644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMC9"/>
    <dbReference type="STRING" id="6205.A0A0R3WMC9"/>
    <dbReference type="WBParaSite" id="TTAC_0000191701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000191701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000191701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="77"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM18644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000191701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42263" checksum="4E9252BFE9529F1B" modified="2016-01-20" version="1">MFLTSSITEYDAADKRMFSSIGVKEYWFPELDNLTKKSGVETINPHMDKISLSRHYFKNGLFSVLLEKSILLFHLQGHWSYTNTNSSEDKWGEVAHKMCNGKKQSPIPLSYADAIYDPHLKPIGVYQHGSFGTNEPFVMTNNGHTLVVNIGSCHYFLDLQNKQDMKFCITQFHFHWGNKSSVGSEHSIDGKFFPLEMHIVAFDKSLYTTFSEASKGVNGLAVLGLVFQEDKNIPRNKTLLFNMGAFLQKVEEVQSPGQAANFTPFPVDALLDIGDANSRYFRYEGSLTTPPCTENVYWTVVAVPVPVSPQQLDAMRFLRYASEESASNMANNFRKLKSVNPDDVVVPRVVFRSWNAASRMAATSLVVLLLVPLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMM0</accession>
    <name>A0A0R3WMM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1995</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000670">
        <property type="protein sequence ID" value="VDM18735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WMM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000200801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000200801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000200801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="248"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000200801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62972" checksum="F2251AB9F41D1873" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMR2</accession>
    <name>A0A0R3WMR2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2037</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000701">
        <property type="protein sequence ID" value="VDM18777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMR2"/>
    <dbReference type="STRING" id="6205.A0A0R3WMR2"/>
    <dbReference type="WBParaSite" id="TTAC_0000205001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000205001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000205001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="164"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000205001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="595" mass="66584" checksum="4986130D76876DB7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN25</accession>
    <name>A0A0R3WN25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2150</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000803">
        <property type="protein sequence ID" value="VDM19044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN25"/>
    <dbReference type="STRING" id="6205.A0A0R3WN25"/>
    <dbReference type="WBParaSite" id="TTAC_0000216301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000216301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000216301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000216301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22259" checksum="D6DAD11A4E7F97C2" modified="2016-01-20" version="1">MFGIWDCCGCNFGYFRFLILATSVKLPQIIKILRTGSAKGLSILGGLLELLCYTATSSYSIQRKFPFSYLSQWLRLFCRVHSLIRSGILFAYLNAGGEYAGHFALSGNFGRSNALIVCLQGLQICTNFRNGSTGQLSAISIFLMTAGSLARIFTSVQETGDVLVILNFVVSSLVNIVLSVQIIYYWNSPLHEQKVIKNKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN62</accession>
    <name>A0A0R3WN62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2187</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000834">
        <property type="protein sequence ID" value="VDM19168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN62"/>
    <dbReference type="STRING" id="6205.A0A0R3WN62"/>
    <dbReference type="WBParaSite" id="TTAC_0000220001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000220001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000220001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132947" evidence="2">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM19168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000220001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31090" checksum="2BCADDE44FE00B37" modified="2016-01-20" version="1">MNMGLKGAVLLFASVTQEICLLTNARRVASVRAETYCNLYALDRTSFQDVLQNYPFMRRTLESVAAERLHQLGRDPLQVIHRKNLQEDLEIVKEIVNQAEKNVNGFSSSSFRYPNISSKTSESGSNSSEKSGGRSQGENTFAWSRTFRSRLYQRKVRVRSSATPHETATDMDEVDDEEDEKPQEEADGRRRDCGHRHRVTPQPRLSLICSPKHRFATKQRIESQAKRRRCSSSTTLKLALRRAAYYGGGGALRKESQMAAKEPVASTSTDQTGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNE3</accession>
    <name>A0A0R3WNE3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2268</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000914">
        <property type="protein sequence ID" value="VDM19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNE3"/>
    <dbReference type="WBParaSite" id="TTAC_0000228101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000228101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000228101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270512at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000228101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="837" mass="92697" checksum="DB0E1829319BC464" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNX3</accession>
    <name>A0A0R3WNX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2448</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001090">
        <property type="protein sequence ID" value="VDM20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNX3"/>
    <dbReference type="STRING" id="6205.A0A0R3WNX3"/>
    <dbReference type="WBParaSite" id="TTAC_0000246101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000246101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000246101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000246101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28347" checksum="7D38831E5D9F9FA1" modified="2016-01-20" version="1">MTPCFKEVDFIVALPLAAANILLSDKGEVKLADFGVAGQLTKTTKKRVTFVGTPFWMAPEVIRVSSYDHKADIWSLGITAIELAEGAPPHSDVHPMRVLLDIPRNPPPKLPERYSSNFRDFVQCCLVQRPENRYSAQELLKHPFVKKPRKTVYLQELIEAYRVAQLRGTLDEDDDDSDTGSTRQHGDNLNGHVLTFKWDFDTIKMPANASAAAQHGGSTSVGGSMVLPAVPAHGPPSPKKPIASQISSPGRNYTHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP11</accession>
    <name>A0A0R3WP11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SLC12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2486</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001133">
        <property type="protein sequence ID" value="VDM20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP11"/>
    <dbReference type="STRING" id="6205.A0A0R3WP11"/>
    <dbReference type="WBParaSite" id="TTAC_0000249901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000249901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000249901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000249901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8203" checksum="AC62BF53E40DEB7C" modified="2016-01-20" version="1">MLYILFLPFSNLVSYVRYLNVKAFVEVTVAGESIREALLHLVRLSGLGAMKPNTVCLGFYDNAEPMVRAFSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPM0</accession>
    <name>A0A0R3WPM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2695</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001389">
        <property type="protein sequence ID" value="VDM20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000271001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000271001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000271001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000271001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="26354" checksum="DFEC02F950C6CCE7" modified="2016-01-20" version="1">CNNILIVSLFERVLFNWSVRHPGSGYVQGINDLLTPFVVVFLSEYTKTGVFPSEQLLDLEGDVFWCVSRLLDTIQDNYTFAQPGIQNNVNKLSSLIERLDNELHRHLMEHKVEYLQFAFRWMNNLLIRELPLRCIIRLWDTYMAEPEGFSQFHVYVCAAFLLRFKDSLMRRNDFHGLLVYLQALPTHRWTNTDIEMVLAQAFQYKSLFSQAPKHLDYQRSEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQP3</accession>
    <name>A0A0R3WQP3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RabBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001880">
        <property type="protein sequence ID" value="VDM21888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQP3"/>
    <dbReference type="STRING" id="6205.A0A0R3WQP3"/>
    <dbReference type="WBParaSite" id="TTAC_0000308301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000308301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000308301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000308301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11271" checksum="441DF225B1C6E629" modified="2016-01-20" version="1">MIKTNPLESSPPSTSSSSVGSDIETGMARVPPTPPRRTLLELSSPEPIPSALVPLERLSLDHAPPSESEVEESETEKPHAATVCEGCRRLEERLQSLQMEHTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR06</accession>
    <name>A0A0R3WR06_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3181</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002031">
        <property type="protein sequence ID" value="VDM22118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR06"/>
    <dbReference type="STRING" id="6205.A0A0R3WR06"/>
    <dbReference type="WBParaSite" id="TTAC_0000319601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000319601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000319601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035014">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052651">
        <property type="entry name" value="WDR81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000319601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42098" checksum="743586587011CC2E" modified="2016-01-20" version="1">MQQTASLFVVKLDRHTSSLTVAKEEQKDSLSFPLDSSLKPALCPLSSVITASDTASLITESPDSQPTSGYQRSAVITELQATFTPEMAYITYIPLCRLAAVELKCGRIGNNFSAFLSSLTPNAGFESPFKLYVGGSHIESSLYNINHIHSLVRQHEASLHGSDNGTTGPTGRVKVTINTEYEAKLVASSSVSKSAVTHLHGEWVEYFRAKVETCPSLPVSPLVCGPPRLLKFIGKHLVTFSGALLFLPVAMRTTCTTFVPGHNGAVRSITPLVNENSFVTTSNDHNVLLYSLTSARESAAVALVASYASRRTVSDSGAFSDRLLGVQSPPSVVASPATQLTPVAPSLVFTGHRRAVFASAYLHFERLVASLDPSLLLLWDPVTGQKVFFVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRA2</accession>
    <name>A0A0R3WRA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KIX_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3277</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002173">
        <property type="protein sequence ID" value="VDM22298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRA2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000329201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000329201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000329201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257497at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000329201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23009" checksum="B032F6E0FCA2B198" modified="2016-01-20" version="1">MALKKDSFIFQSSVFPNLRDSAITVATKRLERTQNFASVNKDLHIFLSEAITYVHQKYANVKPSLIQECKYGTGSGSPGGATQRAASGWSYIYRARRSSNTSSNSDELLRMKRQSSYPGAPWQSEPLTWGSSSGSLPNSQQPAASQSLGSYQSYFSPNRQGGGGGGGGGGGSSSQHSANAPEKLSKWAAQLKLYVRVTFFSLDCYFRAQVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRM8</accession>
    <name>A0A0R3WRM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division cycle protein 123 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3403</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002380">
        <property type="protein sequence ID" value="VDM22560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRM8"/>
    <dbReference type="STRING" id="6205.A0A0R3WRM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000341801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000341801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000341801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000341801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34797" checksum="2BAD38280135DBC1" modified="2016-01-20" version="1">MFRESITFSSIEIQESWSNDGSDDELEATTFPDFEAKVNETIASLGGAVFPKLNWSAPKDAAWINFGSTLRCTSATDLLVLLKASDFISHDIYAPFAFCTDVNDDEPRHPLKLVLRAWRQIRPDGELRCFIRSNQLYVINATDSLVDVMDVYVGHKFGSSRCVRVIDFNVYGPPTDGLMFNWSELRLLRHDKEVHFRWQSDKTMRSSVFSQYKLPIDLVDISSGDDPEKLLDLIKARAVSSLNQGEICLVRFLPAEVRNDACVIGLKRHVASVRANTRRLSAGGMDERDSSVWSGAAITSFVGLGALSFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRR8</accession>
    <name>A0A0R3WRR8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002442">
        <property type="protein sequence ID" value="VDM22642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRR8"/>
    <dbReference type="WBParaSite" id="TTAC_0000345801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000345801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000345801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000345801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="5264" checksum="FF100CC93868CF51" modified="2016-01-20" version="1">MFVICAKKKAKDAAATAAAAVVVVVVAGAASGGTATVAAVLPICEKACKFQLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS36</accession>
    <name>A0A0R3WS36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3561</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002639">
        <property type="protein sequence ID" value="VDM22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS36"/>
    <dbReference type="STRING" id="6205.A0A0R3WS36"/>
    <dbReference type="WBParaSite" id="TTAC_0000357601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000357601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000357601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF709">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="72"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000357601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35377" checksum="861D8DDAD9D05576" modified="2016-01-20" version="1">MAPSMAGIREGVRILFDLGYMKDLMGEVCSVRRDGTQVRSTIDGEVKILNIKNLRRVRVVGPVEVDGVDNMTYIGNILVTVNPYVDLLIDGLDVMGTYRNQPIASMPPHVYGIAEGMYQNLLHDGVDQVVIISGESGAGKTEAFKRILRHLAASSEGDQITWGSAAQGVLESTPLLESFGNATTLRNDNSSRFGKFVEVFFSGPSIIGARVTNYLLEKSRVVQQSPGERNYHIFYQLLSGLDKDTKDAHYLTSISDFAYLQYGKASKVASRSDPEALQVLLNCWSNLRFTGEDMDLCLRIMSGVLHLGNVEFGERDGPNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSA4</accession>
    <name>A0A0R3WSA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosylphosphatidylinositol anchor attachment 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3629</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002769">
        <property type="protein sequence ID" value="VDM23021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WSA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000364401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000364401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000364401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000364401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60307" checksum="6D6609D2BD598F84" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSQ3</accession>
    <name>A0A0R3WSQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3778</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003033">
        <property type="protein sequence ID" value="VDM23344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSQ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000379301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000379301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000379301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000379301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7420" checksum="15FAB53C34BE1B37" modified="2016-01-20" version="1">MEKRHNGLVEDLLEFAYVDGATEFAAAFIVSPAIFQTLKVRLLVMDATGCGGSDGDPSTATNSCNDPKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSX6</accession>
    <name>A0A0R3WSX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003152">
        <property type="protein sequence ID" value="VDM23565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WSX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000386601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000386601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000386601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000386601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="38444" checksum="FD08E7D39351E97A" modified="2016-01-20" version="1">MRTLEKEIDDAALRVTNLAEALRKSAAATHDLLGKVERAIHSFPPSCQYIPQTIRSAMSTRLSNSDLAGLQCYNGSLINVLQFSQAEHERSLAVVQQLNLIAGPALLHRYLPSLIGKVAEGSRMRSELFDDVKGLQQDGPSISSLLPGLLDGPVRRKPGTLRSGLSSKLLFSASAAESKRGLGVKKPVSRIRQASTATSHQQQHRQKSTSGPSGPTSKNPWVSYVAPMGCNHVPEEYLNMLETAAPQVTATLASVEAANPSCSIFPVSDTAHVGDVTPPSATDFANHGPVAPRTVIRPTRVPRPISNMGIETEEMPPCHSRPLVRHHHVPVSSRGTFILPLRSCMGLCGSSGSLSIGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUT7</accession>
    <name>A0A0R3WUT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reticulon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004634">
        <property type="protein sequence ID" value="VDM25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000452701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000452701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000452701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262795at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000452701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27162" checksum="AA05C1B2919614E6" modified="2016-01-20" version="1">MVRIVDESVELTSPVSLQQKKKANKYLNFDSRIYTALITAYLFSGSIKRLLLRRFLSPTFFNAIAPTVLGLIGNGVFITALYKGANWNWLSILFMFGSRLCFGWSTYSAEDYNRRARHVIKIEREIGIVKKRVSDMVPDLQDFSFHAGVIVAIVICFIIEACLQFVGPEMAEFYSLLILSGLSTVLSLVSIPCLHIAVRRLLNMPIECEANAQCCSAPRTRPASSNDDADLTSTDVSLFYCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV29</accession>
    <name>A0A0R3WV29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4604</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004867">
        <property type="protein sequence ID" value="VDM25264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV29"/>
    <dbReference type="WBParaSite" id="TTAC_0000461901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11572" checksum="DC364E61AF76AA9D" modified="2016-01-20" version="1">MESKCALVEQKSNQKAIDQLRSAIEKLILTCIGDQLEEVRSLAFKRLQVFFEKAPLSISAAFCLRWIEEFKAALILGDQGVIPNMACICCCNLALLAKLHLATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV63</accession>
    <name>A0A0R3WV63_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4641</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004946">
        <property type="protein sequence ID" value="VDM25346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV63"/>
    <dbReference type="STRING" id="6205.A0A0R3WV63"/>
    <dbReference type="WBParaSite" id="TTAC_0000465301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000465301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000465301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM25346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000465301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21909" checksum="7E31CB7447F2FF28" modified="2016-01-20" version="1">MMRYGFFTVISLIYWKKPVESAIVMATGFTLLFSVGCLSLISVFAYICLAILCCTGAARVYYDLITSKRDETASPPFSDWLIKDKEALRQRVHDYVNDRFDKTESAIQDLRHYLLIENYVDSLKASSLLLSFALLVYLLSILGGFFNLITLVLIGFTLIFTVPKIYDLYHVQIDKFTEKPKQELRKIWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVZ0</accession>
    <name>A0A0R3WVZ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4913</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005656">
        <property type="protein sequence ID" value="VDM25866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVZ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WVZ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000493001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000493001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000493001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000493001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="16858" checksum="43C74D3E45B62D80" modified="2016-01-20" version="1">MVTYDRVVFEPTKQAIMGGCVTFQPAADTTAVLKERPANETIMTNQQPQQRKVTQSSTSSGLITAASAASSIPAAATAANQSGVGARQYRASRLPAPSTRMTRARANATSSTLLNLPEDAIPQPARNGDSDTTQHSIATDICESCGVPLRCGVENAQFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW84</accession>
    <name>A0A0R3WW84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5009</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005940">
        <property type="protein sequence ID" value="VDM26059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW84"/>
    <dbReference type="STRING" id="6205.A0A0R3WW84"/>
    <dbReference type="WBParaSite" id="TTAC_0000502401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000502401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000502401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000096">
        <property type="entry name" value="G1/S-specific cyclin-D3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000502401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36545" checksum="39C1394BD4C91E3A" modified="2016-01-20" version="1">MENSRTERDLSEKSEDETPATVPQPIADAYFNGNESIIRDLLNDQLRYHAFPAFCHRESVGQAVWMRRTLINWLREVCEHRNTEPEVLAHTVQLIDRYVSLTDTDKRDYQLVGAACFFISSKLKETIPVSVDQIVRYTDFSITKQELFAKELLIGLTLQFDLTMITPIDFIQPLACFIPCGPELQQLIRGSTNKIYMKILHVEGVNLFLPAYVATACIIYAMHLTVEPEQHELPRLTLGRLQEILHLESYKLEEMYSFLRSLFKPGTIHLSDLVTSIDRGDGAHSPEYQSRNSGVLVDNLPQLPVETSTPTGQLSSSSFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWE6</accession>
    <name>A0A0R3WWE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006147">
        <property type="protein sequence ID" value="VDM26199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWE6"/>
    <dbReference type="STRING" id="6205.A0A0R3WWE6"/>
    <dbReference type="WBParaSite" id="TTAC_0000508601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000508601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000508601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375837at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000508601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20741" checksum="32D231B86AF2F0EE" modified="2016-01-20" version="1">MADPERVSEITRVTGAPISLSLAVTDDVNAGGNTAGRLCWLQRRQLMPYSRTEIYCAQLETSGRAVRSKRLLKSFNANEEPSYGLIQDDDTILWTSLYRKVYRSLNPSASINVKGVCCSNGFQSMAIRNICKRSMTNACSYDNGRCRYFCLPGGREMAHVCRCPDDQPNCITEHANSRLVDYTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXA9</accession>
    <name>A0A0R3WXA9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nectin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5384</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007273">
        <property type="protein sequence ID" value="VDM26852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000539901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000539901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000539901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000539901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19951" checksum="27C5F3AD9128790F" modified="2016-01-20" version="1">MRTCEKKFTILELIGAVVGTFTATILLFLIGYILLYMRHRQQYPKSPSKTVYPLVTSTGLPKFPDYQVLESSPQHPIQGPLEAIGNHSCDLATEKRHLMVKTEWTDARRGPEARTSSSVYSECPTYDLPSNHMAATPLPPLPPEPPPPSPPSKTSQFGTVGGVPIVYPQPHFLDPATAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG7</accession>
    <name>A0A0R3WXG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5443</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007539">
        <property type="protein sequence ID" value="VDM27010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG7"/>
    <dbReference type="STRING" id="6205.A0A0R3WXG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000545701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13184" checksum="2EBBFF73BE6CDEA5" modified="2016-01-20" version="1">MPQVLPLAQVITSLSCLTAEDVAKLNQHSRCFKLLHSLRESVGRVPSSSGCGSADSSDFKRSYDRMRRFVNENSAGSGGEGGGGGNEDTGDEILEGVFESSDEESKDCGETHSSPLKVPNTCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYL2</accession>
    <name>A0A0R3WYL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009306">
        <property type="protein sequence ID" value="VDM27780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYL2"/>
    <dbReference type="STRING" id="6205.A0A0R3WYL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000585201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000585201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000585201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000585201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9436" checksum="BA9F88645F3FCA10" modified="2016-01-20" version="1">MQYFLSPFADYVHRIGRTGRAGKSGIAVTFLTKDDTAVYYDLKQLLLTSPVSTCPPELANHPDAQTKPGTFAAKKRRNDETVYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYT6</accession>
    <name>A0A0R3WYT6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CHCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5911</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009668">
        <property type="protein sequence ID" value="VDM27946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYT6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYT6"/>
    <dbReference type="WBParaSite" id="TTAC_0000592601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000592601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000592601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000592601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8580" checksum="8AC9FABC28318039" modified="2016-01-20" version="1">MSGHVYEPLVPADDNEDEDPVIEMIKRTGCLDEHNAIMECMAENKDWRKCQDKVKLFRDCMSKKDRKDGKTYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZB1</accession>
    <name>A0A0R3WZB1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Runt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6103</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZB1"/>
    <dbReference type="WBParaSite" id="TTAC_0000611801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000611801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000611801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251263at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000611801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24140" checksum="0BD2E36491E842B0" modified="2016-01-20" version="1">MELRNPQYYTSAARSRSVGPTIIPPPVDASAYPLVTDLSKGLRSVRTNDGKIAAIVQALPPKKFILGRVASNEDICIETETPFALSIAAKGKQICISKVASADDLQRSVITNAFSSEMVNQSKPEEGIPVSLRLTFGSTPCVNSIASHSAARESSLSKTFRSVLHINMTGGGGPSTTSNLQRPLQRPPLPLTSAATLRGSLPSLPKPPNRSPSAVQTANITFFEQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZK9</accession>
    <name>A0A0R3WZK9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6223</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZK9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZK9"/>
    <dbReference type="WBParaSite" id="TTAC_0000623801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000623801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000623801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000623801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35378" checksum="C79303BA39A8DF85" modified="2016-01-20" version="1">MDFSQSLSIADNYTSLLARIPLSFRLPVPPPDVMRECLSGSPLDVINPLPDKQLPDTPVNLCIRDQRPKSAFVSVNPRSSNRGNPLVSEIWTVPRASLGCEAPVIPLKAKENLYTVLPSTRRRAGWKGLSVCAACFRPFSKMSELNHHYMQKHQELLEREWNAALIKRQRRCYKTSNYRRLICDQPRTQKDVPPVETAWENAAQSQSQSVTEACNRLMARKMEKSPRKSHVCPWCSYCAKWPTELQKHIVVHANSRPYSCIICSNCYKWSWDLGRHFSTVHAGLPNPYKMNKRSLRAQIQRSKCDSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0F0</accession>
    <name>A0A0R3X0F0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0F0"/>
    <dbReference type="WBParaSite" id="TTAC_0000660501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000660501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000660501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249148at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000660501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54716" checksum="29A2FADD8F1737EE" modified="2016-01-20" version="1">MLRHDNSHMNVLLNEIYLVQQKMTPLEITTNEEAEGDSAEADPCENSPVILDTITEEEEEDPSSRSFDTSENITVQHQYSPVERSNSETDLLEAHYITGASYGTEWYVGETNLDYNELRDHATTCGTLSMPFALEQVQTDTSFLVKQEEIEFCAPQLPSKTYNYSSYHFNMNMKDSGSKSLPSVAPPSGAFLLRHTMSSSDACAIDENCSLANSKALSPTRTQLNDVAEWALSSPGVTTIMENQYADLNPRRVPFPLTTEVTCSKDTKKDSDDKCDEEKLENANAKSKMKRSPAVEGVSVLLERTSTSLSDFASGPVELVRNENPADAGSISTSESLSSSLLSLSRRYLDSSPMASRPVYDYGTDETLLEIFMTPALNGMESNGEKIVDIPPSCAGSTNQLSKQVVKALPFSDSEMGLVWRDTCQENSGKVSTAGNHSRLFEDDSDLPFIDTEESYSEAWYITASQQFSWLDRAQLADLDEITLYCGKLTNYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X111</accession>
    <name>A0A0R3X111_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6841</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X111"/>
    <dbReference type="STRING" id="6205.A0A0R3X111"/>
    <dbReference type="WBParaSite" id="TTAC_0000685601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000685601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000685601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000685601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="510" mass="56943" checksum="EBB94753E31F07B9" modified="2016-01-20" version="1">MSELKIIAEIPAPPIFLCGEVVRCEVSVVLMDPKTAWKIRSIEGILVGQYRLNAAAIGDKFKNRPVLNDVFSAPPDNEAKIDSAFISGLDSQSRISWIRQLNSTNQWPLIIHAGKPLAKIVLKSRLPENLPPSYRGNIIRFAYKVLVKAQVNDRPAQLLHLPLRVLPSVGSCYPFDSSISFDSLPCLSGSESHASLGCVYNPFHVDFHSQLGHKGGIPSEGILQKTLMHPAVSAKLSQLYINTQVSNGTTLGHKVQKTESIKRRKRKSLSQSPSALFAEIVSSSSVASFMLSGPNGHICRITIFKTVARLGDLLRGYLDFRAATLPAFECIIRADTYEFLDLTTYPDNDLRSNLLFSALTINVSTAFQNRDVPQANMDNGFKTSWFETRLTCSNVSFLPFAIPISLNAPVEFMLSSKYWNGLCRVQWYLRFQFTVAMSIPRRKPQLSIEPLLFNRFLQEKTVSNQLDYTSPISCETQTFSWELPIRIIPNSPTAFLLPSQSCSCCTFSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X165</accession>
    <name>A0A0R3X165_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6903</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X165"/>
    <dbReference type="STRING" id="6205.A0A0R3X165"/>
    <dbReference type="WBParaSite" id="TTAC_0000691801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000691801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1545884at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16357">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043194">
        <property type="entry name" value="GLOD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="109"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="591" mass="67581" checksum="DC47F93DD77CE912" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1D1</accession>
    <name>A0A0R3X1D1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DPH-type MB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6988</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020336">
        <property type="protein sequence ID" value="VDM31287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1D1"/>
    <dbReference type="STRING" id="6205.A0A0R3X1D1"/>
    <dbReference type="WBParaSite" id="TTAC_0000700301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000700301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000700301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="6">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="5">
        <location>
            <begin position="103"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000700301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44850" checksum="AEC59EA326F9AC48" modified="2016-01-20" version="1">MSVLHDEIEIEDMEYDEDEQLYHYPCPCGDRFEIYKADLEMGEDIARCPSCSLIIRVIYDLDTFLQRTEDEKNTGVISDVFRNCTDFFIQVLASMSSVLEKKAEIDLIRSVFTSDELIFSDPSLIEELDLLASQNLPIEDKDIELTLKIAFPELAIIVDLSISLPIGYPQLPPSIILRVKQSESIVNEKALNTAFHEWLDDACGTAEPVICSVADWLRSALDEDHWDAYLGRDAFKVAKSSPPQPQLKSVTPMDCHPATSSKTLPKKGSQEAEVCYWIFSHHIRNPKKRKVIVDWARESNLTGCCLPGKPGTVVVEGPEDKVEEYWKRIRVLTWKRIQLKDREVITQRRFTNGFFEVGGTLAEKIGYMREHGISQERIAAHFGFKVDESSINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1J0</accession>
    <name>A0A0R3X1J0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent RNA helicase DDX42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020342">
        <property type="protein sequence ID" value="VDM31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1J0"/>
    <dbReference type="STRING" id="6205.A0A0R3X1J0"/>
    <dbReference type="WBParaSite" id="TTAC_0000707501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000707501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000707501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249139at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284:SF13">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000707501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32780" checksum="EA89E19214821FB8" modified="2016-01-20" version="1">MSLEDFFNKKSRKKTKKTINAQELFEQITDGPLRQKTDPEKCTDEMVVANSDDIGEWEPIVNDDIELDFSNIRINDLATIKVEEEQAAASNINPTSKADDSKIVWGGKVKKEDPEIIEESAPKSNVYVPLPLRSARSNLKALPNLESTEEFPTLDAAAQEKSKKNVSTDSRDSSWVEVSRSSVPRRKEGIGVSGSSYASSNSYREDTLSYKHSSFGFRDSCSSRGVGSSSGGAWSRGEALKNKPVSSADSLPAFKMSPWERKPTPSSGTSKPYVVHQQRDILSFTQENRFAQLDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1M9</accession>
    <name>A0A0R3X1M9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GATOR2 complex protein WDR24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7114</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR24 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1M9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1M9"/>
    <dbReference type="WBParaSite" id="TTAC_0000712901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000712901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000712901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254045at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="WDR59/RTC1-like RING zinc finger" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="667"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="735"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1206" mass="131451" checksum="8AD06390124C0B2A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Y9</accession>
    <name>A0A0R3X1Y9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Granulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7246</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020356">
        <property type="protein sequence ID" value="VDM31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Y9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Y9"/>
    <dbReference type="WBParaSite" id="TTAC_0000726101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000726101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000726101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5854875at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00799">
        <property type="entry name" value="GRANULINS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133136" evidence="5">
        <location>
            <begin position="19"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000726101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="709" mass="75333" checksum="66B0EA1D755250D7" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Q9</accession>
    <name>A0A0R3X2Q9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WPP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7579</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020385">
        <property type="protein sequence ID" value="VDM31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000759401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000759401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273969at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000759401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47574" checksum="684A9D0006024D4B" modified="2016-01-20" version="1">MERALEVILSKHLREDVEKCHVLDRKFPDVSCVDHSNDQSPNCGTLLCMEGNGGLVSKICCGNKFLIDGPGDSPLWANFKSQSGSTLMHTGMADSGIKSNYVQKSECARLENAKYLSDLIMLHLLAEESSLKAEIDFLSSGMEAESNELDEAVIQEGVEQLHIQCECLRRACLESIRELSCNDTLETSRLMVDYRMAHQTAQFDAQDRQLMAVKLNCSQLEIFRDIMALEDSALAEQAQCLDKIHTALQKYLDITDDIKVRFNLGNELEAKENVCTASSICSAIDSELRRVLSSLFGNFVGKLDGPDDELNASLLNYLDERTSALDSKSASSLFSLKEYTRVTHEVFDLLCKALHQLGCHGNNEKQSSKVAMQTSSSVYWNELSPFTGVYPQCLIDRLLQARKTLDATTAALQNLEISYELYSGSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X368</accession>
    <name>A0A0R3X368_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7756</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020401">
        <property type="protein sequence ID" value="VDM32206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X368"/>
    <dbReference type="STRING" id="6205.A0A0R3X368"/>
    <dbReference type="WBParaSite" id="TTAC_0000777101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000777101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000777101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16468">
        <property type="entry name" value="RING-H2_RNF11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNF11_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052804">
        <property type="entry name" value="UEC_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359:SF2">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="130"/>
            <end position="189"/>
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    </feature>
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        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000777101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22282" checksum="ADB28E09978B48C0" modified="2016-01-20" version="1">MSKRLYRRSNSSEDGHRRSGHSTSSQPPAWYLENDPILHPAPGLSVPFSQLTEDQQVAIAMRMALISTLPAFIYAGDEKDRLPECVICMCDYEPGDELRKMPMCSHIFHRACIDDWLTRSLTCPSCQQEVPVPSSTNPTTPAAVTTAGAATATTSTGARYTTAGSAGRADEGGISQRSGPSNIDLRQEAQRIKERSKVRICLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3T5</accession>
    <name>A0A0R3X3T5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020431">
        <property type="protein sequence ID" value="VDM32497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3T5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3T5"/>
    <dbReference type="WBParaSite" id="TTAC_0000802701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000802701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000802701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000802701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="638" mass="72316" checksum="690DDEBF66F1EE21" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Z5</accession>
    <name>A0A0R3X3Z5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DDT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8083</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020444">
        <property type="protein sequence ID" value="VDM32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X3Z5"/>
    <dbReference type="WBParaSite" id="TTAC_0000809801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000809801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000809801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="11">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="471"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="2667"/>
            <end position="2720"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="2727"/>
            <end position="2779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000809801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2931" mass="322008" checksum="9805660B2BEF2243" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X470</accession>
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        <submittedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8177</name>
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    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        </subcellularLocation>
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        <text evidence="3 8">Belongs to the actin family.</text>
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        <property type="protein sequence ID" value="VDM32688.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Actin, alpha skeletal muscle"/>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="ACTIN"/>
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    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACTINS_ACT_LIKE"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000819201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="885" mass="101200" checksum="BBEBEDC47E84A282" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4F7</accession>
    <name>A0A0R3X4F7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyrotropin-releasing hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thyroliberin receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8280</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020477">
        <property type="protein sequence ID" value="VDM32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4F7"/>
    <dbReference type="STRING" id="6205.A0A0R3X4F7"/>
    <dbReference type="WBParaSite" id="TTAC_0000829501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000829501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000829501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004997">
        <property type="term" value="F:thyrotropin-releasing hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002120">
        <property type="entry name" value="TRH_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46061:SF3">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00751">
        <property type="entry name" value="THYROLIBRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01846">
        <property type="entry name" value="TRHRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000829501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49134" checksum="B24FB4A7726756FF" modified="2016-01-20" version="1">MDYNTSSSTSLLTNSSHYVSLALRPAIYYSLPYRILGTIAATLILIVGLSGNLLVITVITWSSKMRSPTNCYLVSLSFSDMLFLLHAAAPFIWELYVMIGQWTLGTQACRIIVAMQYLCVDTSALSMAAFSVERWVAICHPMRAQTLCTVNRALKIIAGIWIFCGAYNCVWLFTLDTQVVEYVYGTYQTCTYKFSRMRYSTVYLLDFILFYTLPLGLIFVMYTQIALRLFKFHKPLCLVLNKEKSADNRKAARDPRRSSPLACQLSILEQARQATLNRNGGRQIRSRKQVVKMLMAVVVLFAVFWFPYRTLVVYNSFVTPKRTDYWLILFVKTMAYLNSTVNPILYNAMSKKFRRAFRLLLTQASCFGRQSKMNSVLGSRRTECVRSRDYFRQVHQRRHQLSRTSTSPIQETELQVLTSKTNKEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4H2</accession>
    <name>A0A0R3X4H2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerebellar degeneration-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8299</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020480">
        <property type="protein sequence ID" value="VDM32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4H2"/>
    <dbReference type="WBParaSite" id="TTAC_0000831101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000831101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000831101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280963at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000831101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="54353" checksum="431C629844FB52B2" modified="2016-01-20" version="1">MRVNEARHQTGIEEIRRSYDKELLRLQSLLTKRQAAFSNVGLIELSKEEKDLKGEDYNFYDKESTPKEIELEKEIALQNHLIEGFQKENEALMKENKDLKQKLASTLIPSEDANAIAERLVHENARLQIDFQQVKDELNALKSAQDLASKKGEKDRSHSEELLLNTDSKILKKRIYFIDNNAQDIQEELEKTIRRLEEESCQNRGFQDSLCKLEAEVTAYFPHKLLFTKLKQTKEEQSRLQELLSTSDSKWAQEVKDRQRRIVALNAELRRVRQDHIVAMQTVQEKMRWQNHTQTISSRHLSTIKKQKLKMLKFKTELEKKQSVPSARSEMEDHDFADNPQYSTPVRELQMELRASHQRVSRLETQLNTLSRVHMALITGKSPNEALQWDCGIGERKSTHERIPNIGRPVNMEDESCVSYWRAIAEKRTNDVALLSKEVDKLTNLLEEISTRIPPATGLSIQLSEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4J4</accession>
    <name>A0A0R3X4J4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8319</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020483">
        <property type="protein sequence ID" value="VDM32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4J4"/>
    <dbReference type="STRING" id="6205.A0A0R3X4J4"/>
    <dbReference type="WBParaSite" id="TTAC_0000833401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000833401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000833401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000833401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11863" checksum="B01DCA1C6F6F3EE0" modified="2016-01-20" version="1">MSGDQQPTPAKRPKKESIIDLTRYQDKLIRVKFTGGREATGVLKGCDNLQNMVLDNTIEYLRDPADPSRLTEDTRELGLVVCRGPSVELVCPAEGMEVISNPFVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4Y4</accession>
    <name>A0A0R3X4Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8482</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020514">
        <property type="protein sequence ID" value="VDM33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X4Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000849701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000849701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000849701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000849701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22072" checksum="CACE682F8B58E61E" modified="2016-01-20" version="1">MTNRNANYKLVLLGESAVGKSSIALRFVKSQFQEYQEATIGAAYLTQSIVVGDPPVTIKFEIWDTAGQERYHSLAPMYYRGAHAAVVVYDITNLQSFERATSWVNELRERAPGVKVIALAGNKSDRYQERAVSELDAKKYAQENGLLFKETSAKLSTNVMELFKMIAESLPLSEPPLANSGTTRLGATPDRPAGGSTKCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X529</accession>
    <name>A0A0R3X529_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8536</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020525">
        <property type="protein sequence ID" value="VDM33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X529"/>
    <dbReference type="WBParaSite" id="TTAC_0000855101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000855101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000855101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000855101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27075" checksum="EF2F5587A1F54657" modified="2016-01-20" version="1">MMLCLKEELLSKEKPFGDFLKAFNSLKLESDDVAKSVDETGDLSNAPVRSMYREQLESAINRLGLTMDDYLQAQSVWSGDAAPDEKADADESTIEQEFAKLGLSDKEIEDVNKAASSQMGTIALKFFLLILEKVRMKESLTKKRDLLAQLLSTNFDAISSEQGKYQEILEDIRRDTEYIQEIPKWQIEMQKRLEMLKQMRKRRVAELSASYQQETNQSEALEKSPTLPTDDDEGGENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X544</accession>
    <name>A0A0R3X544_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MYT1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8553</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020531">
        <property type="protein sequence ID" value="VDM33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X544"/>
    <dbReference type="STRING" id="6205.A0A0R3X544"/>
    <dbReference type="WBParaSite" id="TTAC_0000856801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000856801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000856801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069059at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF15">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000856801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39760" checksum="71E862FA0267747B" modified="2016-01-20" version="1">MEILGSEKYYLLSVSDTDLCCSQQDLQRLREPSNPMQSSMAISNFYRSAFKVPTKLSSSPPECKQQQFQNGPFWSSSSGEWKCTLPMEGESPCFYSSMNDLQEGPIDLSLSKGKKTNDLSSLYSCEDGELYPEDLTVQTPTSLPSSNSVLSTVGQSKMPMTMKASSSRRPGRKLLQCPVPGCDGSSHASGNYASHRSISGCPKADKAIVQAFHVEQKCPTPGCDGSGHVTRNYTSHRSLSGCPRAHLMGIKRQHQILAYRSQQQAQAQAQLSCLSLCRLQALSSLHSRPKSGEAGTQWTPDSMIKPDAPVARKAANDFPPPKESHEIGVNEVLKAEALFSTAHLLNTGGSSIVSQTFNKQDSIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5E2</accession>
    <name>A0A0R3X5E2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8666</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020559">
        <property type="protein sequence ID" value="VDM33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5E2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5E2"/>
    <dbReference type="WBParaSite" id="TTAC_0000868101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000868101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000868101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000868101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20932" checksum="897DADA8C1898A99" modified="2016-01-20" version="1">MSTEPVVYQLRRPSSDKSWGFVLQGGADQGLPVFVHKITRNGIAHRAGLEPGDVIVKICKTPLSGMSHSQVKAELLRAGSDLDFTVLKRAFNVTNYNMSMKMMAAEQASPTLSPGAPEERSEIVEEHLWRHGGPTFKNVQPKSYKILEQQLPQSEMGGTGPGSVFERSVDERSPYLKATEQTIQKAYGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5K7</accession>
    <name>A0A0R3X5K7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8743</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020575">
        <property type="protein sequence ID" value="VDM33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5K7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5K7"/>
    <dbReference type="WBParaSite" id="TTAC_0000875801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000875801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000875801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000875801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22397" checksum="8B7E9ECD241BB1D7" modified="2016-01-20" version="1">MDVSLDEIISMNRALRRGRGSKSQNELRRTSGGRVQKRRINDFPRRSLPDKWQHDLFLGNGSGVPKGNAKILISNLDYGVNDDDIQELFQEFGILRRAAVHYDRSGRSLGTAEVIYANRADAAKAIERYNGLPLDGRPMNIQFVGAADGLAAARSRLGNVPRGRQQRGRGGGRGGRRGNRSTRPPVTKDQLDAELAAYTAQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6H4</accession>
    <name>A0A0R3X6H4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020677">
        <property type="protein sequence ID" value="VDM33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6H4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6H4"/>
    <dbReference type="WBParaSite" id="TTAC_0000910601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000910601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000910601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415359at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000910601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="64011" checksum="91E056E2B1C65325" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Z8</accession>
    <name>A0A0R3X6Z8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9293</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020750">
        <property type="protein sequence ID" value="VDM34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Z8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Z8"/>
    <dbReference type="WBParaSite" id="TTAC_0000930801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000930801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000930801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728874at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000230">
        <property type="entry name" value="Leucine-rich repeat-containing protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000930801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27064" checksum="33ADF3AE1926FE08" modified="2016-01-20" version="1">MGNNVSSRYENAKKTGSLQLSNLKLSKVPEDVKKLVNLRVLDLSFNSIRMIEPWIGSLSSLKSLNISGNKLTCLPTDVSRLTKLETLDASSNRMLSLSCSQRAVNFGLLQHLRTVNISNNNLTEFPVELCSKDIPLDLLDLSKNNIDFIPDCASLLQVIELNLNDNWVSAVSASVAKCPRLKVLRLERNRLRLEDIPLAILENSSISLLSVEGNPLSIKALQELPAYAKYMERYTATKRKAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X757</accession>
    <name>A0A0R3X757_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9359</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020779">
        <property type="protein sequence ID" value="VDM34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X757"/>
    <dbReference type="STRING" id="6205.A0A0R3X757"/>
    <dbReference type="WBParaSite" id="TTAC_0000937401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000937401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000937401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000937401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15112" checksum="7FB4AFF9563705FF" modified="2016-01-20" version="1">MTPTPALHPMSPSTPISTMNALLECKSNCQGELAGFSFYVDRVHRMLLRGNCTQCVSDKAPVCLAVVLEYLVAELLGVASGVAVDNEIGCMLPRHMHLVICEDEELNNLAANTITPPSSMGTVWDVAAGHEDGEVHGHQGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8D2</accession>
    <name>A0A0R3X8D2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9792</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021052">
        <property type="protein sequence ID" value="VDM34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8D2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8D2"/>
    <dbReference type="WBParaSite" id="TTAC_0000980701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000980701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000980701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990815at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="37"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="310"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000980701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41979" checksum="37F5E9293098F4D0" modified="2016-01-20" version="1">QCSDAFPHHRDAKDEVVPFYRAKKWHCVGGGKVEEEEEEEEEEAATQFVAIQFTKGFRETFTEETKECAAVESVFSKLFTLLDPLRAQAIDFLSELESRFAAWSTRLESTARGSHSHSSAALTVTSASGSASSASASATSADADADSPTTPVRIGDLFVTNLKMLQLYRSYLCETECLIIDLERLVRSRASFQSKMQSYEAQKSCYLPFYAFLLKPMHRLLQYRSVLERLMRHYNESNPDMQDCRVAHARLLDTIQSQWDSYKRCENLYKSLEVERDLVGVQVTGEVTTATTSGSGREKPTGWLASRSRQFIREGLLQKLSKKGYQQRMFFLFSDQLIYASRTNAPFLQFKDWLICMDPPFHWSSVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9A1</accession>
    <name>A0A0R3X9A1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10113</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021321">
        <property type="protein sequence ID" value="VDM35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9A1"/>
    <dbReference type="STRING" id="6205.A0A0R3X9A1"/>
    <dbReference type="WBParaSite" id="TTAC_0001012601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001012601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001012601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10332492at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001012601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18610" checksum="77DB9B0A6551C433" modified="2016-01-20" version="1">MVNNEPLPRLELVISETESEMSGSFTSYSTPSATSPQPTHCACERNLKVYNESSRRQEEQIKLAITNFPSKNHQNYEEREIRRKERNNAASRKSRALRKRRFQQMLLETERLTNSNAKLRALVEELNSIMAESKAILFKKFTSPITSNSTMAAQQPTANLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9F3</accession>
    <name>A0A0R3X9F3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10163</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021373">
        <property type="protein sequence ID" value="VDM35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9F3"/>
    <dbReference type="STRING" id="6205.A0A0R3X9F3"/>
    <dbReference type="WBParaSite" id="TTAC_0001017801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001017801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001017801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236246at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="194"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001017801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58790" checksum="9500ABEBD9E5C586" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9W8</accession>
    <name>A0A0R3X9W8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10328</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021559">
        <property type="protein sequence ID" value="VDM35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9W8"/>
    <dbReference type="WBParaSite" id="TTAC_0001034501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001034501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001034501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001034501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12021" checksum="174809CA87713330" modified="2016-01-20" version="1">MSMFAVIELLPRLQSLQPSSQVAVQAQPQWWWRRQPSTTTVANIPTVVATTTRMVSSIAASAQTTTPTSVPIASLSQPQTTEPTSTGMSMANHRTPSLRLSLCFAYNSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA32</accession>
    <name>A0A0R3XA32_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10392</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021639">
        <property type="protein sequence ID" value="VDM35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA32"/>
    <dbReference type="STRING" id="6205.A0A0R3XA32"/>
    <dbReference type="WBParaSite" id="TTAC_0001040901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001040901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001040901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="110"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001040901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46008" checksum="10E469D2DA9F8FAB" modified="2016-01-20" version="1">MLHQCEVFNSLDLEGWCALEVALETERRGEESWRGSPLYQQLCPLGLGHDNTDSSPTWYVERVEVESTETGEISLFPCNQWIDKVSENDEAYVDLPIQLAPSTIPPQSTIFYEFKIYTSNIPNAGTKASVYVVLTGLKGQKTSEVQLKGAFKQGCCEILYVDLEDVGEPLQSLHIRHNKEGINARWHLDRVEVRPMGSKLSDEEVYIFTCNRWLSDTATGGVTLNAAIGKRKLSSREEKNTYEIAVTTGEMSNFANTSGHVYLSLIDADGRREVRQLVARKGSVKPFQPGKSTYVKKSNADVEFMPVDSKVSIPSPASPPERHNVDMSEVNGEIPPIPSLEKLPPVPSESSVPSLSPDMPLPSPPPIGFNGSPRMPPLQQEGNNVTMEVPSRFHNPLPPLPPTKEEEEGNFSDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA92</accession>
    <name>A0A0R3XA92_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10452</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021716">
        <property type="protein sequence ID" value="VDM35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA92"/>
    <dbReference type="STRING" id="6205.A0A0R3XA92"/>
    <dbReference type="WBParaSite" id="TTAC_0001046901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001046901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001046901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="203"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001046901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41551" checksum="B188A50A99CFDA8F" modified="2016-01-20" version="1">MMNNLKRLEDNLQRYMFLIGLQDRNETLFYKVVTEHTEYCMPLIYTPTVGLACQKYGLVFRRPRGLYITIHDRYNIDDILKNWPEPIVRVSLGDLGAYGMGIPVGKLSLYSALAGVNPRHCLPIVLDVGSDNQDLLNDTHYLGISHKRIRDARYEELLDNFMRAIVRRYGNNCLVQFEDFGNRNAYRILERYRHDYCTFNDDIQGTASVTVAGLIAAGRLTGRRLSDDIYLFVGAGEAASGIAHLLKTAMVMHGVPEGDAINKIYMFDKDGLLVEGRPENNIDEHNCTFARTDVEPMRNLEEIVRKLKPTVLIGASGVGGLFTHRILQQMRKNVDRPIIFALSNPTDKAECTAEAAYSTTGVGDSMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAF0</accession>
    <name>A0A0R3XAF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021785">
        <property type="protein sequence ID" value="VDM35490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAF0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAF0"/>
    <dbReference type="WBParaSite" id="TTAC_0001052701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001052701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001052701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001052701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="712" mass="79320" checksum="D212AE1AF1886D6C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAK4</accession>
    <name>A0A0R3XAK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10564</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021867">
        <property type="protein sequence ID" value="VDM35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAK4"/>
    <dbReference type="WBParaSite" id="TTAC_0001058101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001058101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001058101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF157">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001058101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="48288" checksum="6B0C3C443CD5C8D5" modified="2016-01-20" version="1">MHIPSLHAPLPPSPVTRTRTASLLPPPLCHNQTNTSHRLPHLPPPPPPPPPGSEGGGTRKSAVEQCDAMSTAFNALLTITSPLPSPPLPNLLNPLKKARHGGGIIVFSSSSSSFLNPLRRQFDSAVDEVGFACFGGNLTEWLEFPNELSCTVVYADNACKVENYTKWWHGESGLRHQLNLTAACNSVCRVRDYNNRFGDWFSCPQASDYNPVCWESSSSPLPGNGDAKIQMSFLNPCLAGCASQGFHTEPDGKVVEIYTDCNCVTNTSLVPEGVHSLGGSALRGTTKKGVCRPQCLRYAPFLIVTFLTIFLTSVNQNPSNVITLRISSHELFMLAVSCVAPEDGTAALGLQVFFSRTLAFIPTPIYFGALMDRTCRVRALPQRVICESQQHHLLLLSAMKLAPLEGACLEYDVHALPFAWLGGVTVFKCLSILIAILTWRYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBM8</accession>
    <name>A0A0R3XBM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10938</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022572">
        <property type="protein sequence ID" value="VDM35918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBM8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBM8"/>
    <dbReference type="WBParaSite" id="TTAC_0001095501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001095501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001095501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="76"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001095501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16743" checksum="18A93F72018EA848" modified="2016-01-20" version="1">MEVLKLLRVSPLPKLTDYEVCIAVSLVDTTALETSWSSIGGLDEVVTDLLDSVILPFRASTYLLPRSRLFRAPKGVLFYGPPGCGKTLLARATARAANARFFNLQISNLVNMWYGESQKLAEAVFSLAHKLQPSIIFIDEIGKHSGPYMKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBT9</accession>
    <name>A0A0R3XBT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022705">
        <property type="protein sequence ID" value="VDM35979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBT9"/>
    <dbReference type="STRING" id="6205.A0A0R3XBT9"/>
    <dbReference type="WBParaSite" id="TTAC_0001101601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001101601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001101601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001101601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="26059" checksum="682F04D39A606182" modified="2016-01-20" version="1">MDFGITTTRWTAFACTDRQFLASLSPFTVVVIPSIVSLPAPVTYLNGSRTELSLTCEVWPPTANISFFIAHPAIMGTEGGSPLSLYPISSDSNGLFSISRRVSTPLNDSIGGGVPAFSNTSVSLTVRGGGVGSGGGGDAASKLWRLGAVDVHCKASTQFGSVLSAPFRVVQTRLPELSTPSGFTNTRVQEFISGNTAFVSCRIPPDSQPPPIIQFYLNDTLITNASEFLFSSPPCILRCSVIEGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBX9</accession>
    <name>A0A0R3XBX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022788">
        <property type="protein sequence ID" value="VDM36019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBX9"/>
    <dbReference type="STRING" id="6205.A0A0R3XBX9"/>
    <dbReference type="WBParaSite" id="TTAC_0001105601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001105601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001105601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001105601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25453" checksum="DD0B90E2077AE0A5" modified="2016-01-20" version="1">MAARSVWRAILDLYQSNLASEEARIEWHSTLYQSASKLFDLERLRLSTLQEALEFYRSAITESVQFIEKAFQTTRDTLTKANVEEDFISFHGKAVIASNTTPHHSSQGQPSTNRITNSRVLCRTNKAQPLAVVGSAQQYLLCLPGEDDSLYTPSKEIQKQSIRQALQKRFLIFPKDGPDTISSEVLADSAKRSEKAAFARQLIMSALNILVRECEKEERTKQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBY3</accession>
    <name>A0A0R3XBY3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11043</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01022794">
        <property type="protein sequence ID" value="VDM36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBY3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBY3"/>
    <dbReference type="WBParaSite" id="TTAC_0001106001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001106001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001106001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001106001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12713" checksum="308F57A01FC43C7E" modified="2016-01-20" version="1">MASYVFRVDPSDKVPPGKIGFGLAQRKWANISLDQTLSLDPCKISPDVYLSLAHFTVEMYGKKQGPRDPINSDVLSQRFSMHMGDLPLTVGQPLLFRFDQLLLSIVVKSLSGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCA0</accession>
    <name>A0A0R3XCA0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11160</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023095">
        <property type="protein sequence ID" value="VDM36140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCA0"/>
    <dbReference type="STRING" id="6205.A0A0R3XCA0"/>
    <dbReference type="WBParaSite" id="TTAC_0001117701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001117701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001117701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001117701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35599" checksum="E48670C20C978416" modified="2016-01-20" version="1">MKEEGQLESKVKVAAEAARAKTFFDFLGQILFRSQSVKTPAPKRSGQIPPPPRPLTKPKLMEERKSRQQTSPTTSSFDSATAINAQTTSSAPTSNLRQDVFRVTLYVFHSSLLLVSYLAWTAFFILLLPAFCISYCIRQFGLLLAQHRRSSLVETLSSLSLHYLHGEDAGRTTVVLIYLGSPGIKIAALKRLLVQRIFSTTQKRTSNGSQGMEKWFSERLQQTIVPLPTGYAWQRCTSINIDEHVMPAYLVGQNRLGYGRRLSPKKKPPEEEGMVEAEKDPVELLVGQLAAVGLPLNRPLWQVHLVEDYYDTVSFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCK2</accession>
    <name>A0A0R3XCK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1534 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023406">
        <property type="protein sequence ID" value="VDM36242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCK2"/>
    <dbReference type="WBParaSite" id="TTAC_0001127901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001127901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001127901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001127901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10781" checksum="0BF5CED72316EDE8" modified="2016-01-20" version="1">MVTRRHYSADDSRANRHARQDITATGISAVTSCGRLVIVTLKLSLKLAASLIFYVGVGHRPGGERHDKRRLHLCCQHPERRRESNFCAIEAGAVCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCW3</accession>
    <name>A0A0R3XCW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11373</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023818">
        <property type="protein sequence ID" value="VDM36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCW3"/>
    <dbReference type="WBParaSite" id="TTAC_0001139001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001139001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001139001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133288" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001139001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13210" checksum="42EBD9323028DF38" modified="2016-01-20" version="1">MQSASILLCLLLLLVCASHPTLAAVVRFHDADWQPTHWCEDVIDRRDVAQVADGRKRCSPADGVEVIGISVDPHQWRRGWMRREGGSRVRRVKRQLRFSRPIYSPRLPPTPTMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDK3</accession>
    <name>A0A158RDK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynein intermediate chain 3, ciliary</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS781</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000097">
        <property type="protein sequence ID" value="VDM16983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDK3"/>
    <dbReference type="STRING" id="6205.A0A158RDK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000078001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000078001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000078001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16983.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000078001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="917" mass="104055" checksum="D177821C0680173A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE10</accession>
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        <submittedName>
            <fullName evidence="12">RNA-binding motif protein 17</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">TTAC_LOCUS6422</name>
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    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <citation type="submission" date="2016-04" db="UniProtKB">
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                <consortium name="Pathogen Informatics"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000643701-mRNA-1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REH4</accession>
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        <submittedName>
            <fullName evidence="10">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1</fullName>
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    </protein>
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        <name evidence="8" type="ORF">TTAC_LOCUS7291</name>
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    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
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        <citation type="submission" date="2016-04" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
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        <property type="gene ID" value="TTAC_0000730601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INI1_DNA-bd"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000730601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="51522" checksum="C69E14DF9ED58100" modified="2016-06-08" version="1">MQTILRYGEKPIEFQLETDGEFYYLASEVGRYLRLFRGELLKRYPNLWKRLTTSEERDKLIAMGMLFQSNPFLLSSLHFEYRLISNTGLATPVTALNAVILRAIEVDELIGGSEDRFKSFEPSLNGSIAPSAIRPNLAGSTTSSLSGSVFGSTTAMSSPTAALTATGTAVGGEGFTNSSANPLKPAGGGGGSGGGGVGVSGVGGSSVVGGGSGGGGSRSGGSAAGRWIVLSVLLLTIDEDYSTPTDKVSSKVSNFPICLDDSDPVAYHENAQQPEHLVPIRLDIEFDGVKLRDCFTWNRTEQLITPEQFAEILCDDLDLNPISFVPAIAQAIRQQVAAHPVENILSGQTDTRVIVRLNIHVGNMSLVDQFEWDLSEPANSPEQFAARLCAELGLGGEFVTAVAYSIRGQLAWHQRLYAFTESPLPTIDVVFRSPNEADQWSPVVEVLTDAEMEKKIRDQDRNTRRMRRLANTQPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REQ8</accession>
    <name>A0A158REQ8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS7823</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020409">
        <property type="protein sequence ID" value="VDM32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REQ8"/>
    <dbReference type="STRING" id="6205.A0A158REQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000783801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000783801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000783801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="269"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="505"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="623"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000783801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75692" checksum="360F9E9654C514A3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF13</accession>
    <name>A0A158RF13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8539</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020526">
        <property type="protein sequence ID" value="VDM33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000855401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000855401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000855401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247498at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000855401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1287" mass="145381" checksum="B09C2AD64DE05229" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF70</accession>
    <name>A0A158RF70_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9065</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020670">
        <property type="protein sequence ID" value="VDM33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF70"/>
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    <dbReference type="WBParaSite" id="TTAC_0000908001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000908001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000908001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000908001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35696" checksum="8EEB3BCC4BCFB973" modified="2016-06-08" version="1">MPEGISERWMPLNPDPRSAAYPLMESFWPTALISLAYVVGVYTWMKVAEPKSKKISANGHSSNGNAVSKKEVAKASSSSYDIIKCLMVVYNIAMIFYSAFLVIEVIDLLRITGYGLGCVEFDPKDDPIQRRFIRVGYLFYFSKFLELLDTLFFLLRGKYDQVTFLHVFHHGAMPPSIWWGIKYAPGGIVYMFPLANSFVHVIMYTYYGMAALGLYRYLWWKKYLTVLQMVQFCIFIVHQGQVLTPFNWECRYPKVFPLAIVIYAVIFLVLFSNFYVQAYWRKRRLAKRVDELNGSAVTNGKMNHKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQU3</accession>
    <name>A0A3P7EQU3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000743">
        <property type="protein sequence ID" value="VDM18874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQU3"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000314">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate synthase central-N" evidence="3">
        <location>
            <begin position="48"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamate synthase" evidence="2">
        <location>
            <begin position="438"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="89239" checksum="28452AC224070453" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F3B3</accession>
    <name>A0A3P7F3B3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F3B3"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="246" mass="26999" checksum="C87A4C42FB0C3D32" modified="2019-02-13" version="1">MGEIAQYRQVDSARVSECVGSAMAWNVKTNPLSVGSILVGAAAQANPLLLILTAVDQAVDVSSTYVFTGAVIGCLYWSAVTYGALTVMQVCGHEAGLTAMERTDPVVLLLGLPAIPTCLIAIHMVDWQSWFLRLWRSRAYKLAVIQYLLPKDICRSRLEEARDPEGGSTIPRILCTSLALPSFAVFFGRLLFSRVQSRIGQAIAVSGCFQGGGLFYLGVTGFLHIYQREMTFLRNCRRHIVEYDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FG39</accession>
    <name>A0A3P7FG39_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021263">
        <property type="protein sequence ID" value="VDM35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FG39"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="558" mass="61201" checksum="86B7EF95D351055A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGD5</accession>
    <name>A0A3P7FGD5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021369">
        <property type="protein sequence ID" value="VDM35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGD5"/>
    <dbReference type="OrthoDB" id="6250975at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="974" mass="106249" checksum="15B41E46278C5317" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FH51</accession>
    <name>A0A3P7FH51_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021536">
        <property type="protein sequence ID" value="VDM35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FH51"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="363" mass="40002" checksum="2AF52EFCAB01A168" modified="2019-02-13" version="1">MPSELKGGKPVGKFVFGDFNMSSQIQLLIAGCEDMNCGKSHIFIHPLTSSGVWEKVDVEWNPPDLEGDCSLVPTTVDRFSSAAILGMSLGDADLDGYPDLAVGLRCVRSLNSDQIILPAILRNLAGAGERVRFQAYLLPGVESKGILKQIAFYDYNEDGILDLYISYEDKDGVSTSLYMQKLTKEAYFLKVMLTTGLCGSSSQCPNGVLPYGLPGYGFRASYETQGVDGGRIRSSGVFVTSSCCGALQLPFTTFGFGDFATYIENVPVSVPAPAQQIRKHELTFIVPNAQVVVVPYPPNNPLNWQAKLFLQPLYDMKVIYVAITLLVTCIVLLIVVVVLQYLEVREDQKERMQESQRFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FHC6</accession>
    <name>A0A3P7FHC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021826">
        <property type="protein sequence ID" value="VDM35520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FHC6"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="420" mass="43721" checksum="D3E248153D2C445F" modified="2019-02-13" version="1">MSKSIEAVGKKDDKKRGFLDPDAPEFKPSGFIIPLEPTSLAGTAFNPVAYSQPVPLSVSGFAASNQHSLPNGGAPAVQFSLPSSVSCVLPSTVAPQFTALRHSQISFPPQQLAMVSQQLPASGSLSTQPNVAPTAAGSRGPRQSVPAGNYSKQRSVDQANAASQQLPFPMFSPQGFSFVQSASYPIGVPLISTMPGNFQSTAYAGVHALTGAVSASQTSGQQSSTSHSAQPPSGQVNHIQTSSQAITSSPQAQGTQFHPGYNPHLGSVQCPAGVAAYSQYSTGQLIGSQASGSLGYYSQPVYQAPGLIPFPIQQVGAGGQPQIGSQLQSQSQQSLIPSQPLQLQAAQQQGAVQSVQQQPQPHVFFTAGPYQLSPQQVLAQAMTMGVPHQAVPNTFGIPQNVHPQPHPVQLYMPQQPNSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQP7</accession>
    <name>A0A3P7FQP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021029">
        <property type="protein sequence ID" value="VDM34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQP7"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="240" mass="26473" checksum="C25F487FB7338AF3" modified="2019-02-13" version="1">MNFSTTRPSSSTFQLTKVEEPSKFGVVIFESETGQVKRFVEKPTEFVGNRINAGIYLLNPSIISRIPLKPTSIEKEIFPILAEEGSLYCMSIEGFWMDVGQPKDFITGTALYLAYLAETEPKTLAAGPNICGNVIIHPTAKVNANSLIGPNVVIGPDVEVEEGVRIQASTLLRGCKVRNHSWVSNSIIGWNCCVGKWVRMENVSVLGEDVEVVDEMYVNGGRVLPHKQIKDCVTEPQIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FSF2</accession>
    <name>A0A3P7FSF2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021662">
        <property type="protein sequence ID" value="VDM35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FSF2"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="117"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="350"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="457" mass="50959" checksum="EBCFBB309B35F665" modified="2019-02-13" version="1">MVILDDVKFPKYAEIVRITLADGSVRTGQVLEVSGKKAVVQVFEGTSGIDAKNTTCEFTGDVLRTAVSEDMLGRIFNGSGKPKDGGPSILAEDYLDIEGQPINPYSRIYPREMIQTGISSIDVMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVKKRGGDGAEDERDNFAIVFAAMGVNMETARFFMQDFKEHGSMENVCLFLNLANDPTIERIITPRIALTTAEYLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLASIYERAGCVEGRSGSITQIPILTMPNDDITHPIPDLTGYITEGQVYVDRQLHNRQIYPPINVLPSLSRLMKSAIGAEMTREDHSDVSNQLYACYAIGKDVQAMKAVVGEEALSAEDLLYLEFLSKFEKLFISQGAYENRSIFDSLDIGWDLLRIFPKELLKRIPETTLNKYYPRRMERQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GR68</accession>
    <name>A0A3P7GR68_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RSE1/DDB1/CPSF1 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003827">
        <property type="protein sequence ID" value="VDM24345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GR68"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="82"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="539" mass="59631" checksum="DC597E1404B9482D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GV74</accession>
    <name>A0A3P7GV74_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005543">
        <property type="protein sequence ID" value="VDM25792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GV74"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00122">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MBD" evidence="6">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM25792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="157" mass="17788" checksum="066E0E0F32650AA7" modified="2019-02-13" version="1" fragment="single">MDDPSSGYRSESPFDYKGLNPLEIPLRAGWLRVYIKATPEAEGRDVIAYVAPCGRHIRSFSELDHFLHQTGSQLTSDLFCFDKEIKINGEFRCEKAFIRIADLSYGKENVPVPCVNSVDNESPCFIDYIPNRKPVGNVEINEDPDFLVCCDCTDNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HAN4</accession>
    <name>A0A3P7HAN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HAN4"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="257" mass="28569" checksum="1B982F02230CFCEF" modified="2019-02-13" version="1">MQKIGLPGRGDVCFLSPINVIYLFIPSLLVMDKFTTLDVLLRAELSPGFPDLFPDSTFDKLSKICESKGMSLVMGVIRYAVTCGLKVLRLCEEKLLDWLNDNFKHICEAAHSIASRRFMRHLENMLSCSGCDCNNAAFSVDNPTEGNALTSSDVDSSVLKRLAFQFVADKLPRQLVDKLFTSLCLDSLPTAEGGIDQTEDCGKPKVFRATMTHNNASKALWTSSTTAKPLVTKFSDQNKRMKMAKGTKSIMSFFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HBA0</accession>
    <name>A0A3P7HBA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020361">
        <property type="protein sequence ID" value="VDM31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HBA0"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="939" mass="99847" checksum="157E9B9AD96D88E1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHP0</accession>
    <name>A0A0R3WHP0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">TTAC_LOCUS69</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000004">
        <property type="protein sequence ID" value="VDM15781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHP0"/>
    <dbReference type="STRING" id="6205.A0A0R3WHP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000006801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000006801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000006801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM15781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000006801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17395" checksum="245CA0941542ED56" modified="2016-01-20" version="1">MDTRIIDGITNSSASIGEDRSCPDDDFVDRVNHTYTMNLLMFFTAIVLSRQLVGKPISCWIPNDFTGAQGEYAETVCWVTSTYFIPPAQATVPIEEDIRYEKKIYYYQWVPFILMIQAALFVLPCIVWRLFNAQSRINVSTTNCGFGPKWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHR4</accession>
    <name>A0A0R3WHR4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS101</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000007">
        <property type="protein sequence ID" value="VDM15847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHR4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000010001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000010001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000010001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="249"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="552"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM15847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000010001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117543" checksum="43DD3ACF102481F9" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHT3</accession>
    <name>A0A0R3WHT3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS121</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000008">
        <property type="protein sequence ID" value="VDM15899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHT3"/>
    <dbReference type="STRING" id="6205.A0A0R3WHT3"/>
    <dbReference type="WBParaSite" id="TTAC_0000012001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000012001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000012001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM15899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000012001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18443" checksum="47E9A178B1A24F22" modified="2016-01-20" version="1">MASANVRSGRYYCHGFVEEIDPNDMDSVINDFSGNPDMPPISNFLAAIQSALGNITVGFTSDNPNLNTSQDEPVSANTRSRSQRRPDMMMGGIELFMQMLLNADLNPFNMGGPPPATPADIASLPRKILSKADLKTYDVCSICLEKFSVDDEILTLPCLHGFHQPCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHW1</accession>
    <name>A0A0R3WHW1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS151</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHW1"/>
    <dbReference type="STRING" id="6205.A0A0R3WHW1"/>
    <dbReference type="WBParaSite" id="TTAC_0000015001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000015001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000015001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419752at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="372"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM15987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000015001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57454" checksum="EBED46C08180CAF1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WID2</accession>
    <name>A0A0R3WID2_HYDTA</name>
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        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS352</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000028">
        <property type="protein sequence ID" value="VDM16295.1"/>
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    <dbReference type="STRING" id="6205.A0A0R3WID2"/>
    <dbReference type="WBParaSite" id="TTAC_0000035101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000035101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000035101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BACK"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
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        <property type="entry name" value="Kelch_1"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF419">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
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    </dbReference>
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        <property type="entry name" value="BACK"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
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    </dbReference>
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        <property type="entry name" value="Kelch"/>
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        <property type="entry name" value="Kelch motif"/>
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    </dbReference>
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        <location>
            <begin position="38"/>
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            <begin position="712"/>
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        <location>
            <begin position="800"/>
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        <location>
            <begin position="872"/>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16295.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000035101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110449" checksum="4F59DA7A3BBED3F1" modified="2016-01-20" version="1"> </sequence>
</entry>
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    <accession>A0A0R3WIS9</accession>
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        <submittedName>
            <fullName evidence="9">YL1_C domain-containing protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">TTAC_LOCUS526</name>
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    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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        </citation>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="protein sequence ID" value="VDM16585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000052501"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="WBParaSite" id="TTAC_0000052501-mRNA-1"/>
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</entry>
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        <submittedName>
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                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
            <dbReference type="EMBL" id="VDM17009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000079901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23545" checksum="30DB7DFA00936CFF" modified="2016-01-20" version="1">MSAFMKRYGKFHRVLFPYRWPITSVRQVSVTLHLFSPFRVLGKQTAPDNSKRDASAAADDDDPFYLCDYKTSAEISPASTTITYRISYKPRQLHLIDWLRRLAQGCFHGVSTALSGADDKEFTTLITLFANQRHQSRSLQVPVICVGLGDACFTYPVFQIAADMVGQGGHKLWQNEVQSSIFEHAAQLRMTDVYEELYNSRYANSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ4</accession>
    <name>A0A0R3WJJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Breast cancer type 2 susceptibility protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS844</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000111">
        <property type="protein sequence ID" value="VDM17068.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A0R3WJJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000084301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="711" mass="76883" checksum="94D2B0FE344A929D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJQ0</accession>
    <name>A0A0R3WJQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS914</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000128">
        <property type="protein sequence ID" value="VDM17170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000091301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000091301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000091301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="516"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000091301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71517" checksum="BF64A8E98CC5F50A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJQ6</accession>
    <name>A0A0R3WJQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000130">
        <property type="protein sequence ID" value="VDM17179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000091901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000091901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000091901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033291at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000091901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30253" checksum="32926C2337297E0F" modified="2016-01-20" version="1">MGGGDSSRYELYRGRGSDQWGFKITTLDNHTYITGVYECTPAAKAGLKINEIVVTINRVPCALIYGVTDLLLAQTSPPKNSEDVENRHYSKPKKSSEKINSSPPKENVETREKSSSKHRSKSMTALYEINVEDSQTDVRRRRTKYEQKKRQSHRDSKMIEDRLNIEVPKNGTKNHAHLGKSVDRTESTSHRRESNNPYEPEADMTQMENCRSSAVLQQQEAESVTEQNPPFPSMSDLQRSLPAGKRRTLLLNTGKSLEDRIASLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJR6</accession>
    <name>A0A0R3WJR6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000132">
        <property type="protein sequence ID" value="VDM17191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJR6"/>
    <dbReference type="WBParaSite" id="TTAC_0000092901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000092901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000092901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6233505at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132886" evidence="1">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000092901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58738" checksum="DD666C65F7406A95" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK35</accession>
    <name>A0A0R3WK35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1064</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000169">
        <property type="protein sequence ID" value="VDM17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WK35"/>
    <dbReference type="WBParaSite" id="TTAC_0000106301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000106301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000106301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000106301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28843" checksum="1608702A5DF53D5C" modified="2016-01-20" version="1">MNAKTGKISHDLDSICLYLAQQTVDRCFFFRDTMQRFSLIGGTSGSMEGTKGILGPTLLLSVGNWEKRLVGSQAKAIRWEIPFRHIWSGNRNTLLHCSFTLERVDEATPGLHCTIACQQDGVPGTQQVLHLNVNSGSPEGKHLQLNPTSGSSYSEQNEFRLPSFVVFQLCSMLDPIAPLGNDWRQLAQHLAMERFLPYFASTQHPTEMVLNLWEASTTARGPLAHQELINILQSMHRLDCANLVRSQVSLVSSRKDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKL3</accession>
    <name>A0A0R3WKL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUC153 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1258</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000237">
        <property type="protein sequence ID" value="VDM17707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000125701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000125701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000125701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10412294at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000125701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8904" checksum="4E4358434663162B" modified="2016-01-20" version="1">MGAQPAKPSKKSRVEEDRTHKEDTFAEATSKKGSIDAMTTIEDWDLNDLWDLNDHRSVVPEHHDKSKFASKSSRHGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKZ6</accession>
    <name>A0A0R3WKZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000300">
        <property type="protein sequence ID" value="VDM17950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000142301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000142301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000142301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000142301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9986" checksum="DDB9746BA0FB699B" modified="2016-01-20" version="1">MVHPDVVAETSVAIEVGVDAEAVELQGEIEGVEEEEEMGYHTANHSVDLKDSEVEVGHSKKIANICTSELNTPTNRHLDGERGWWRMVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL78</accession>
    <name>A0A0R3WL78_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1501</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000347">
        <property type="protein sequence ID" value="VDM18111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL78"/>
    <dbReference type="STRING" id="6205.A0A0R3WL78"/>
    <dbReference type="WBParaSite" id="TTAC_0000151401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000151401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000151401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="37"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000151401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42249" checksum="1067EF0C5E1BF4BE" modified="2016-01-20" version="1">MQVQSRARIYADVNLNKPREYWDYENYTINWGDQDDYQIVRKLGRGKYSEVFQGINVTNNTNCVIKVLKPVKKKKIRREIKILENLRGAENIVSLLAAVKDPVSRTPALIFEYVDNKDFKDLYQNLTDYDIRFYMFELLRALDACHSMGIMHRDVKPHNVMIDHPMRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLLDYQTYDYSLDLWSLGCMLASMIFKKEPFFHGHDNYDQLVRIAKVLGTVELFDYIRKYNIEMDPRFNDILGRHGRKRWDRFITADCEHLATPDAIDLLDKLLRYDHHERLTAKEAMEHEYFASIRKARSEGAAAAAVVAANNGSKEGCNSVGDVNSKDVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL93</accession>
    <name>A0A0R3WL93_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MCM7</name>
        <name evidence="13" type="ORF">TTAC_LOCUS1518</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01000355">
        <property type="protein sequence ID" value="VDM18138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL93"/>
    <dbReference type="STRING" id="6205.A0A0R3WL93"/>
    <dbReference type="WBParaSite" id="TTAC_0000153101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000153101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000153101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="361"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000153101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="768" mass="84674" checksum="00D0A0A327B15818" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK3</accession>
    <name>A0A0R3WLK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1628</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000415">
        <property type="protein sequence ID" value="VDM18309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WLK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000164101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF248">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN UNC-71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="809"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1350" mass="144825" checksum="55A746778CFBA8A2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLT5</accession>
    <name>A0A0R3WLT5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1710</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000461">
        <property type="protein sequence ID" value="VDM18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLT5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLT5"/>
    <dbReference type="WBParaSite" id="TTAC_0000172301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000172301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000172301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279422at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="72"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="597"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000172301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="663" mass="73092" checksum="47AE992747DBD86F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM14</accession>
    <name>A0A0R3WM14_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoU_methylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1789</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000511">
        <property type="protein sequence ID" value="VDM18529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM14"/>
    <dbReference type="WBParaSite" id="TTAC_0000180201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000180201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000180201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000180201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8132" checksum="7BC5F8D4DAF79714" modified="2016-01-20" version="1">MESILGSAKCGEQVVFCMGSEECGVAANMSKVVVLRGSGGVVALDGGAAGDGAGAGTFGVRRWAYNSHIHLSDVSDVNAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMH6</accession>
    <name>A0A0R3WMH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CARD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1951</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000630">
        <property type="protein sequence ID" value="VDM18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMH6"/>
    <dbReference type="STRING" id="6205.A0A0R3WMH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000196401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000196401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000196401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1357022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041452">
        <property type="entry name" value="APAF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17908">
        <property type="entry name" value="APAF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000196401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84901" checksum="6F1396083D90BFD1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN80</accession>
    <name>A0A0R3WN80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CST complex subunit CTC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2205</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000850">
        <property type="protein sequence ID" value="VDM19235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN80"/>
    <dbReference type="WBParaSite" id="TTAC_0000221801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000221801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000221801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258948at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000221801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="827" mass="90934" checksum="E7CA754680677C7B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNM5</accession>
    <name>A0A0R3WNM5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exportin-5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000992">
        <property type="protein sequence ID" value="VDM19767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNM5"/>
    <dbReference type="STRING" id="6205.A0A0R3WNM5"/>
    <dbReference type="WBParaSite" id="TTAC_0000236301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000236301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000236301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2215036at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="121"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000236301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56254" checksum="316815F0030CD815" modified="2016-01-20" version="1">MDKIVACAYSGNVLSSRTVAVTTFTPLISVEERKAGRRILLAHLHDCFANADACLPADPGMRQYHLSILHTLVISCTEESSEFCLHLLMQDFATLRYNPYALATGKTVAVTDPKISKYLNVRCQSVRDLHMYVGVNVFRLVRAQTSSMLPYFDSFCSELNNIWTNGYGGLGERCLLLEVVIYLALRLPCTFAEQRDKLSIILAGVLTEWNNPKCPLVIIGADKAGNEGKFKGGTEWLIDYFGLSMDADEILGSMDFLTGRVATRLELRWISLATVAIVRQLKGTLSPEQTDAVSIPLIEKLVVPAFNLLRTLNKLWQPKTAQLCHPSMRSVLEVTHAEMALLANIKLKNPSRNSDPESLVTVEHREISEDYVPKLQSFLTQLYESTIHICNFMVAITASRFYALPTDQLSHLLYNYMCPSIDSLPDFRLLQLLRESFPTFHLLRALKTSFQSFKVGLFDFFSSNHHFCEGIFAVVLFVIITQSSLLEKRLRLIPSLYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNV2</accession>
    <name>A0A0R3WNV2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2427</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001070">
        <property type="protein sequence ID" value="VDM20009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNV2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000244001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000244001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000244001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266770at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone H2A C-terminal" evidence="10">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000244001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22630" checksum="294E910C90FD2B96" modified="2016-01-20" version="1">MGPLNQSEHPLLLLLPPPPPTICPHMGYNDAIPSSKPVMYFAFLMAVAARLEILYARPESRDSRSNRSIAYFCRQSRDEWRGKRGKSRAKSKTRSSWAGLQFPMGQVHRLLRRGDYAKRVGAGAPVHMVAVLEYLAPEVVDLADNAVRDNKKTHITRATIRKDEKLRKLMDGITIGQSCMLPHIQAVLMSQKEEKPVASKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP15</accession>
    <name>A0A0R3WP15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001136">
        <property type="protein sequence ID" value="VDM20200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP15"/>
    <dbReference type="WBParaSite" id="TTAC_0000250301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000250301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000250301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035275at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000250301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50781" checksum="8A598D0CC6B8B87C" modified="2016-01-20" version="1">MNASLSTSPQLRLIRFAQLTAQNVQFTFLLPACLVRGFISEVDSATFEYGNHMWRLRMVRTSLHIGAYLELVIPSRVTEGASSEEDFSLWLDFIFTVINLNHFSDNQTFTEKQVLFNRENMSRGSGCLIEATVINERNFVHEDGCLLVELELANVEVSLSLPLSLSKENHFESSCFVYGGEIWKAEMTVDLKFRASFNLSCQSTDQTLGYLVSFELLVNSTLEVSPRLDLLVHQSGGHIDLPDDINAQIFSSWTESFHRGLIFICLKGIRLYRVGLFILPNDLTEERSFLKCAEDAGGSSWTVAFFVASECLHVCLTPQGAETSALQPNSVRVVGWSWCFRDDPLQHFGEVQQVYIRQREPISQQHYLQTDPYIPAEVIHRKDSLSSQAQKNMREADEEVKSECTDPIFLSGSNLKVSNFLCVCNSSPCKKLCLFWYHLKLALEVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPB7</accession>
    <name>A0A0R3WPB7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2592</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001253">
        <property type="protein sequence ID" value="VDM20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPB7"/>
    <dbReference type="STRING" id="6205.A0A0R3WPB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000260701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000260701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000260701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021598at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696">
        <property type="entry name" value="AGAP012002-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000260701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57100" checksum="DBC0B4ED90189720" modified="2016-01-20" version="1">MDRKGRRKPPIRRLRAPRVSKRTKFLFSLSTKEHLLHGDIREETVEERIAFLPPLPSTLAIQSRALDQDILQLIKEEVVRFVGLKNISLEWVRGLLKEVASGTRKHRFHSTTSRPWLAFKECAATMKNPYLVPGTHNEQILQEKDEEKDAAPIESNSPKLLSESSESPPIKKPRSRFMATLFNERSFESSHLSTQLREIVCKGTTTLEKFIYKKPIEKVRYRAKDCGLGVVLPLQVVPKNNARWLFRMDVEDTLGMTAYVWKKWIHAQLSKRVVIAKSITDSEIRFSLPSDLHALEGLSVIDYLETNCAIAKSRMVIYEALYSRMKQAVINVQALKEAILKLIPTTPAENCLNELIDLLDLPEDYAFKTSTFCKCLGLSERLFAPVDKSNNEDEEISMDEEEQWKFQAGPLERLDFCQVSRRLTPLEVNPRLKRLLEKLERQINWQLKDFQIVPFSRRFTENPIKRLFKRAKSSIHKYETAKMHSTFRFAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ42</accession>
    <name>A0A0R3WQ42_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ApaG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2867</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001608">
        <property type="protein sequence ID" value="VDM21368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ42"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ42"/>
    <dbReference type="WBParaSite" id="TTAC_0000288201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000288201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000288201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5913487at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="63"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000288201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25231" checksum="B06FD0B346E067D2" modified="2016-01-20" version="1">MDYAFHDDIIPYTSKNALPLRNEYFEEFLRFDPSREPHFCPTERLQGWLEARQSSLEMKTVHRETTEGVRVTVVPFLMGQRKFRVSRCRRMRWYSEKTLNYYWRYLIRLENFTDECLQLRERFWKLFSINGSLESVSGKGVVGVQPLLSVQSPVFQYHSHVQVPVPWAHMWGQFRLEKPNGTTVDVKIPVFPLCVNDFQEDHGSATTDSGDSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQC5</accession>
    <name>A0A0R3WQC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2950</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001721">
        <property type="protein sequence ID" value="VDM21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQC5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000296501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000296501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000296501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF237">
        <property type="entry name" value="ATP-DEPENDENT DNA_RNA HELICASE DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="5">
        <location>
            <begin position="133"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000296501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31968" checksum="A414D9F0DB319661" modified="2016-01-20" version="1">SSSKNLFITTPFSFSITIEDIVYVVDSGQIKITTYDPSTNTSTLARVLVSKANAAQRRGRAGRVRPGQCFHLFSSFAHDRVMLDFLPPEITRIRLEDIILRIKVNPYHVLELGPVASFLSSCMDPPDLETIRRTLQFLRDIQALKPRVPACTDSVPTAQLSRMSKRKRDRLFEGVIKTATVGSPVAEENDVLTPLGHHMANLPMDPQCAKLLILGTFFCCLKPALAVSACLAFKEPFEVPLGSEALADACRAELTEGSQSDHWAFYVALSVSPTLVTKLLTTFISSVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQJ1</accession>
    <name>A0A0R3WQJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3016</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001804">
        <property type="protein sequence ID" value="VDM21750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQJ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WQJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000303101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000303101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000303101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000303101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16078" checksum="5DD422F928D14307" modified="2016-01-20" version="1">MPNVRQMRQGDSAWTQPSTPRRRRNLSVSPSDASARAMRQCILHSQASVAIDQPIEYFDPGRAEEEVMAPEDFRLGGPRECLYTSYLRRRLRETRPCSLDDGTMDDQHRKNTAAIPRRKLIGTRAISFDNPYFDVPQGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRE4</accession>
    <name>A0A0R3WRE4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3320</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002246">
        <property type="protein sequence ID" value="VDM22394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRE4"/>
    <dbReference type="STRING" id="6205.A0A0R3WRE4"/>
    <dbReference type="WBParaSite" id="TTAC_0000333401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000333401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000333401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10046198at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000037">
        <property type="entry name" value="B-cell lymphoma/leukemia 11A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001175">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM22394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000333401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33914" checksum="4194C58D5B114C25" modified="2016-01-20" version="1">MKPPQRKSSFLTVRDLLDTCSVGSNESPSSTSASPTEESVCSHPPPTASKPHGELKLGSTSLIDDAKTPSPIPQTSCPIPFFYPSYLNYSCFNLLKGPSEMKKQRRSITPPPPPLPPASQTFNAYRRERERERRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHEKDGRPSHRCRYCQTPFIVPSTLEKHMRRCGARVRGEARFLTSAPPPSQAPIPPPPPPPPPPPPPPPPISPQEIYGRAFSNALPSILSPWCYSLFSSLTPNSSAHPPPPPPPQSGLLPGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRS0</accession>
    <name>A0A0R3WRS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002444">
        <property type="protein sequence ID" value="VDM22644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRS0"/>
    <dbReference type="STRING" id="6205.A0A0R3WRS0"/>
    <dbReference type="WBParaSite" id="TTAC_0000346001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000346001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000346001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000346001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22297" checksum="2691C3BB0AB1E0C7" modified="2016-01-20" version="1">MAKNGTFRAACEYKLVFAEGDVCFEPYPTCDDMNWGPSWLHTRHYGLEFAHPSGVISLPPGRLTPSGHHVEPGRLELRCTRLRPEVQLFSKLKCNRFSDESLGQFHRIHLTEREAIFELNLPEPGNSHCFLYSYNTGVAFIGMSVCGERACQTASCDLTPVSASQSYLSRWQHGMLSAPAATLGSPHLLHTLSRLKSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS09</accession>
    <name>A0A0R3WS09_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3534</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002601">
        <property type="protein sequence ID" value="VDM22823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS09"/>
    <dbReference type="STRING" id="6205.A0A0R3WS09"/>
    <dbReference type="WBParaSite" id="TTAC_0000354901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000354901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000354901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10327092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000354901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6839" checksum="38A5DABEE855D112" modified="2016-01-20" version="1">MPAGWAAMLRKAGISVREQQQHIEVIWNALEICTTNKSTGTVKYMNDLSINTSTFYTRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS14</accession>
    <name>A0A0R3WS14_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3538</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002607">
        <property type="protein sequence ID" value="VDM22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS14"/>
    <dbReference type="WBParaSite" id="TTAC_0000355401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000355401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000355401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000355401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38868" checksum="989256C9FAA8C394" modified="2016-01-20" version="1">MVVKMDVSTLDPFRICMDRIRNAQKESKRVRKERWETARGEASRFKLFAVYNESKKVLHLLEQTPKKSDNESHLLRCEFYFATSECQEELMAYAKQQVIEMRQSKTSTDHFKNRRLLQPLPSVHTHPNLITDEFEEMTCKLTDNLNSQGTVYSLIKSVFKDPPDEAVVNQLATILGSQLHLHQYLVTFKQPKHLLPYLIHIFGGSDRTFHLINKALMGDLWSIYRIAKYVGFDLKATVRLLTSVEKTVAAATSCLVTKPCHFHHVEDLVNELLRREWTSADLIELANGRYVQSLKPGEKPNRNPLLTVATSMSENAFLEFYRALHQLNHRYFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSU1</accession>
    <name>A0A0R3WSU1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3819</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003106">
        <property type="protein sequence ID" value="VDM23471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000383101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000383101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000383101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000383101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7276" checksum="B7C5BE7F43C60B0B" modified="2016-01-20" version="1">MGIVVDLSDEVRATAPIYEGLYNYVFTSDTECEVLRGIKEQHCFMTLGFASELTTASNCHSLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT11</accession>
    <name>A0A0R3WT11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3886</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003236">
        <property type="protein sequence ID" value="VDM23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT11"/>
    <dbReference type="STRING" id="6205.A0A0R3WT11"/>
    <dbReference type="WBParaSite" id="TTAC_0000390101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000390101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000390101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000390101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20142" checksum="97B815B0E5844722" modified="2016-01-20" version="1">MQVRCLQIDSTAGAMDAPSDADDSRLVINDVAAYNRVFKPKHAIARSPNRLPFDGGSTGVPPLPPSSLQANVTTRSMQKLYIAPSSEGEDEESGPFYPPPQPQSGIRKPLPIGLLTSVLSNVDTCGAVQPFSLAAALIPTVRGVQSQLEPMLSDKNFVFLSIYSSLPLVLKEYPENKVSAEVFTGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT52</accession>
    <name>A0A0R3WT52_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein HID1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003306">
        <property type="protein sequence ID" value="VDM23779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT52"/>
    <dbReference type="STRING" id="6205.A0A0R3WT52"/>
    <dbReference type="WBParaSite" id="TTAC_0000394201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000394201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000394201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000394201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38279" checksum="4F441E3A58856446" modified="2016-01-20" version="1">MGSGQSVLNYRSAFVELTNKTQPIDAYNDEFWDQFWCGGPTRISEMFASVPGSEIRTLREESPGNLATLCYKAVERLAHIAEASFPTTQDQQTAINCVRLLTRIIPYIFEVPEWRPFFWSVLPAQQDSNPDAASSVPLAQTLISSLCDLLFCPDFTVQSITKSGPENAEDMHTIDSCEYIWEAGVGFAQSPPQNAQHDANRTEIIRLLLVCFSETMYLTQDEALREVNKWIAFFSGPENRHVLPLFTSLLNVVCAYNPASSSLPYNHLMFTDTREPLVEAALQMLCVTLEADFRNLDDGKTPSDSTTPDSTGNNLFLNYMSRIHRDEVRLYAVSQFLCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTD2</accession>
    <name>A0A0R3WTD2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003465">
        <property type="protein sequence ID" value="VDM23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTD2"/>
    <dbReference type="STRING" id="6205.A0A0R3WTD2"/>
    <dbReference type="WBParaSite" id="TTAC_0000402201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000402201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000402201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253545at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000402201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13663" checksum="708CFC387CD415D9" modified="2016-01-20" version="1">MQPSFCVARERRGEKELYRQVLNGDMSSWFLSYSPDYTQTTNSAATVEGRCSRGDNCEMCCSRQLYYQQDSPPHQQHHLTSQHSVPEDPPTDLLRRYSPVLATSSQVSNHIRQINRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTQ3</accession>
    <name>A0A0R3WTQ3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4130</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003728">
        <property type="protein sequence ID" value="VDM24245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTQ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTQ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000414301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000414301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000414301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM24245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000414301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31654" checksum="7360C357999826AD" modified="2016-01-20" version="1">MGVRGNRKHLKRLNAPKHWMLDKLGGNFAPRPSTGPHKLRECLPLAIFLRNRLKYALTYDECTKILAQRLVKVDGRVRTDKKYPAGFMDVISIDRTNEHFRLIYDTKKRFAIHRIHPEEAKYKLCKIRKVLVGPGKVPYIVTHDGRTIRYADPEIKANDTVQIDLATGRVLSFIKFEPGMVKFNHISFPSGNVCMVTGGHNLGRVGVITQWERHPGSVEMVHVRDNTGHQFVTRLNNVFIIGKSNKAWVSLPKGKGIRLSVLEERDRRLRVKRTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTR2</accession>
    <name>A0A0R3WTR2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LSM5</name>
        <name evidence="15" type="ORF">TTAC_LOCUS4137</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003749">
        <property type="protein sequence ID" value="VDM24264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTR2"/>
    <dbReference type="STRING" id="6205.A0A0R3WTR2"/>
    <dbReference type="WBParaSite" id="TTAC_0000415201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000415201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000415201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM24264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000415201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9725" checksum="389ED00A2BF07B85" modified="2016-01-20" version="1">MESAIGSTHLLPLELIDKCIGSRIHIIMKNDKEMVGTLLGFDGYVNMVLVDVTQFEFTAKGKRITKLAHILLNGSHIAMMVPGGEGPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWH8</accession>
    <name>A0A0R3WWH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5102</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006271">
        <property type="protein sequence ID" value="VDM26271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWH8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWH8"/>
    <dbReference type="WBParaSite" id="TTAC_0000511801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000511801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000511801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000511801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8319" checksum="AE8FD7FB1CB9956B" modified="2016-01-20" version="1">MLVSGKPYKRQFVVCGLSRRSAAGEIIADLKKSIEQYFSEKYGIRLKYPELPCVKLLCDCGDDDGGGGGGGGCGGGGGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWX5</accession>
    <name>A0A0R3WWX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4880 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006766">
        <property type="protein sequence ID" value="VDM26562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000526501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000526501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000526501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000526501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9402" checksum="9A2005DEAF4678D7" modified="2016-01-20" version="1">MDYAHVRLNAEHNVDAIDYRIREYVCVRTCTDQSAALAHAHPDWREHWQPIAAPAGLASTHKRAISAYNAHLNHVSVDDSSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX43</accession>
    <name>A0A0R3WX43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007017">
        <property type="protein sequence ID" value="VDM26676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX43"/>
    <dbReference type="STRING" id="6205.A0A0R3WX43"/>
    <dbReference type="WBParaSite" id="TTAC_0000533301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000533301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000533301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000533301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19606" checksum="9350F8813A124B1C" modified="2016-01-20" version="1">MVFDEEASRGLVRWAEEREFYTGKRAVIPPPRNPSLLQSGICAHYGAQLSTIPTAQWPGLLVRPIDLPPEDPGSYAVLGANVSGLCASSPVPDHMAEQLPAELHQRGVASYLDYARFKYGTRLRLVEETRGLDSSTPLVTATRISRHRNAANVSLGFLSANVILTLLCKVEGCLISFCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXZ3</accession>
    <name>A0A0R3WXZ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008249">
        <property type="protein sequence ID" value="VDM27336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXZ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000563301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000563301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000563301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000563301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11857" checksum="574CC5F2B20FAB13" modified="2016-01-20" version="1">MAACVEGKRLRGGVVLFGGRLHQHYEEFFSQCAPTVQLWLMRSSREVVPRVNVAGIICPVCNMNSTIARLHYVMHHSTADYLLSPMNSMWSTHLECHEDHLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY60</accession>
    <name>A0A0R3WY60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5685</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008564">
        <property type="protein sequence ID" value="VDM27439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY60"/>
    <dbReference type="WBParaSite" id="TTAC_0000570001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000570001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000570001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000570001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="5815" checksum="2363AE20C9DE5792" modified="2016-01-20" version="1">MGREEDLNVEVQMPQHGIEVVMGWEDGSGGSGGGGGGGGGCNGRQAAAATATVAQLLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYI1</accession>
    <name>A0A0R3WYI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Swi5-dependent recombination DNA repair protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5806</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009141">
        <property type="protein sequence ID" value="VDM27699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000582101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000582101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000582101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10406621at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000582101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34644" checksum="46847D98FDA064DD" modified="2016-01-20" version="1">MGRKRRSSCKCRKQRGKRSSPVWRRQQLDATSMGDQVRMEEWREKQADQERQQHQQQEQECDRKIISDFQKLAQQEVIRVFTSLFDSALSSYKAAIERMNERKSEGLHRLGEYKEELISYRIRIDNLHLQEALSRITLREDEHELRHFLDRFKSEDLIGVDLLYRRDPRDSENKDSDVDVGDPHEETEARRSNGKDSDTEDDDGDAEKGIADRGVEYASSDSTSTIAGMESRYGLVRGSDSETEDLSTDKESVDLAVEDRGKAVEGSNTKTEAQSTDTESTIPAVEDRDASEEEGDVKTETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ71</accession>
    <name>A0A0R3WZ71_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase greatwall</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Microtubule-associated serine/threonine-protein kinase-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS6046</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ71"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ71"/>
    <dbReference type="WBParaSite" id="TTAC_0000606101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000606101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000606101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000604">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM30190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000606101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="556" mass="61300" checksum="D19512FE02095586" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZC8</accession>
    <name>A0A0R3WZC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF4206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6125</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZC8"/>
    <dbReference type="STRING" id="6205.A0A0R3WZC8"/>
    <dbReference type="WBParaSite" id="TTAC_0000614001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000614001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000614001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20805">
        <property type="entry name" value="C1_DGK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022786">
        <property type="entry name" value="Geminin/Multicilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07412">
        <property type="entry name" value="Geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111469">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="5">
        <location>
            <begin position="436"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000614001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="671" mass="74534" checksum="68B3A5FDDA258938" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0E3</accession>
    <name>A0A0R3X0E3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6582</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020309">
        <property type="protein sequence ID" value="VDM30812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X0E3"/>
    <dbReference type="WBParaSite" id="TTAC_0000659701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000659701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000659701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="102"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="882"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000659701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1547" mass="176787" checksum="D502CF71EB8F9ADE" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1A4</accession>
    <name>A0A0R3X1A4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6952</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X1A4"/>
    <dbReference type="WBParaSite" id="TTAC_0000696701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000696701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000696701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="286"/>
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        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="407"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000696701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56462" checksum="6CF4D2C23E741790" modified="2016-01-20" version="1">MGEYSPLPNAEAPPPEGNGSYPPFENELDDSRSNLKEDEQRRHDDERDGVRHYDENEEERYERDRRRDRRRSRSSSRGRRRRSRSRSRDRHRRRHRSRDRSGSSSRRIVYKYWDVPPPGFEHMTPQQYKALQASGQIPVNVYAAGQVPMPASTPNAPLTLNTNIPFAGSAVCRQARRLYVGNIPFTATEENMMDFFNKQMKAQNLVQAEGNPIIAVQINMEKNFAFLEFRSVDETTQGLALDGILFHNQALKLRRPRDYAPLPGVSETPSIIVPGVVSTVVQDSPHKIFVGGLPNYLNEDQVKELLLSFGPLKGFNLVKDGSTGLSKGYAFCEYVDPNVTDHACAGLNGMQLGDKKLIVQRASVGAKNAGGAMPPPLIQVPGLNDALVQNTTGSGNIIFRSGGPPTEVLCLLNMVDPEDLTNDEEYEDIVEDVRAECSKYGIVSSVEIPRPIPGVEVPGVGKIFVQFASLVDCQKAATALTGRKFDNRLVVTSFYDPNKYHRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1M2</accession>
    <name>A0A0R3X1M2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF5741 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7105</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X1M2"/>
    <dbReference type="WBParaSite" id="TTAC_0000712001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000712001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000712001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257987at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040262">
        <property type="entry name" value="At4g38062-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043979">
        <property type="entry name" value="DUF5741"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45287">
        <property type="entry name" value="OS03G0691500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45287:SF4">
        <property type="entry name" value="OS03G0691500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19012">
        <property type="entry name" value="DUF5741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5741" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="813"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1335" mass="150774" checksum="DC3449453255717D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1M6</accession>
    <name>A0A0R3X1M6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7111</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1M6"/>
    <dbReference type="WBParaSite" id="TTAC_0000712601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000712601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000712601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10509153at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133166" evidence="1">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15134" checksum="18EE47C9F1943EA3" modified="2016-01-20" version="1">MALARTIYTMISMSAKSTLLLTVGILLSLQAEATLAPNCSSECIEEVTVEYYNDTLGGIMDGGGLRIEMASTVFLTNLDCLIFSLPSPRMFHIYFHLNDRPYSSTSISTLPPVLQAKGGFCIDPQKRFVYQPNGLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Q7</accession>
    <name>A0A0R3X1Q7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RPOL4c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7149</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Q7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Q7"/>
    <dbReference type="WBParaSite" id="TTAC_0000716401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000716401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000716401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000716401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15541" checksum="1A27F48D9FB56C34" modified="2016-01-20" version="1">MAQMRAVDDDSDAKELRFQKGDITRCNLYSSYRKKQNESNPIHELELSNNFTKTYNYATQFSKFNNRETIESVRNLLVQKHFHNFELAAIANLLPDTAEEARVLIPSLEGPRFPEEELQQILDEIQSKRSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X284</accession>
    <name>A0A0R3X284_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020366">
        <property type="protein sequence ID" value="VDM31735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X284"/>
    <dbReference type="WBParaSite" id="TTAC_0000738201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000738201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000738201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6308911at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000738201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19218" checksum="F1931BFC9D44392F" modified="2016-01-20" version="1">MNPFYGTNNYDYFYGGTSSTSATNMDGRRKLANIINRSDDSSIAIGGGGGGGRDVGFDFDGVSMNAQPSTSQMPLQGTNSRASHMDHGVFAVPQHPVRSAYQKRNTKFSGTATVPQESLPQRHFQPDGMAFSAKISTRSDMRRPLSDAEVQWAFEGVSDLRYFGDPKFQLFVSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2D6</accession>
    <name>A0A0R3X2D6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">TTAC_LOCUS7432</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2D6"/>
    <dbReference type="STRING" id="6205.A0A0R3X2D6"/>
    <dbReference type="WBParaSite" id="TTAC_0000744701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000744701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000744701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000744701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26116" checksum="7D22F9BA152922D4" modified="2016-01-20" version="1">MELQSKIEKLRADCSNSDLQISACQRQLKKQKLDAMVKAVKNPTDVDELIKFAHRISCSYGALAPDNWVPGDPRRPYPNKEEIRRGYLGHLDDSGHFLPTLKDAIAQFQSTAYSPSLSVSNVNVVPSPGGMMSSNGSGSHWIDQQQQLRHLPSSLTAILSSVGSASGRPPRGLPESPSPRIRWQQHQQQVRQGLLGVHSSTPPQAKKRPHIEEPRMCSDTSSDDDGRFGDFTHRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X318</accession>
    <name>A0A0R3X318_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aldose 1-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7701</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X318"/>
    <dbReference type="STRING" id="6205.A0A0R3X318"/>
    <dbReference type="WBParaSite" id="TTAC_0000771601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000771601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000771601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000771601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43235" checksum="D938ACB989563732" modified="2016-01-20" version="1">MEDWGRTSRGAPAKRITISPLLSEKLSMGPDAEVWTKVRLTILSYGAAIQQLWIPGFTDTGGRRKSNLSVADVVLGYSDIASYERNPAYHGVIVGRVAGRVSNAKFTIPIELDPSISTAYKLPKNQQKKHCLHGGNTGLTFRLWDIVEVKKDTVRLKVTSVDGEDGFPGNLTVYVTYRLSVNEEDQRVNLSIDYFANITDGICPINLTNHTYFNLAGHRAGPDALDRHLVCIHADKMCECDTEHIPTGRLVKVGRVDGTDLNQLTCLKEGLRKIHPPPQQGFDEYYVFRDLPADETKAIVIEPNSCRRLELFTDQLGVQFYTGNHLDPKTDPVGKDMYSYPPHAGLCLEAQGFPDAVNRSNFPKQFVTPTGVCYVQKTRYEFSVQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X378</accession>
    <name>A0A0R3X378_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CACTA en-spm transposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7769</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020403">
        <property type="protein sequence ID" value="VDM32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X378"/>
    <dbReference type="WBParaSite" id="TTAC_0000778401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000778401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000778401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6228408at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000778401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34401" checksum="29C49C7D047985F9" modified="2016-01-20" version="1">MVQELQHHRAISNSSMCRDENSRPSHLIALALETSRAHSADSKSSNLFGKGKAQNRRRRRPRLMSEDLSDNIKRNDIELLFQQCPKGFRSFSRCSPPLQKGSIDSRSTFHYRHLAEGSVKLAMSCWSAGRPNIPVIRIHDANTEDAVHSNRLAGIKRSSSLNFIEFETHDNGTKARTLSEEMILIQPSTTSDGVSYSFAEFDELRTSVYSIHGSTKSSSVSPLTLVVLRNNGFLQRSLMNQRRCKSSNDIDRDMESVNPESPIRQVSSDFNLSSLNAELLAELVETANILGQALEMHLKQQASIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3J4</accession>
    <name>A0A0R3X3J4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protocadherin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7908</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020420">
        <property type="protein sequence ID" value="VDM32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3J4"/>
    <dbReference type="STRING" id="6205.A0A0R3X3J4"/>
    <dbReference type="WBParaSite" id="TTAC_0000792301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000792301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000792301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133150" evidence="11">
        <location>
            <begin position="25"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="159"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="269"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="506"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="613"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="752"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000792301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123973" checksum="E141E950E7277C02" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3J8</accession>
    <name>A0A0R3X3J8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7913</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020420">
        <property type="protein sequence ID" value="VDM32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3J8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3J8"/>
    <dbReference type="WBParaSite" id="TTAC_0000792801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000792801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000792801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133167" description="acid phosphatase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000792801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49838" checksum="D915EF4E9852AD6E" modified="2016-01-20" version="1">MILQWGLLFFLVTCLVDGLGGNESLLSVFILARHGERYPCHILRHPGYPKEFMKMRCQLTETGARQHFELGRFIGRRYSSLLTWKGFKRNDVHIRSTGTERTILSATYFGLGLDSSKEVKLPVLPAVFSSPKRHDYLLKMSYPCSAFDKLYEKALTSNLTRDFINRMRGLFDDLNNFTEFNFESDSLHKYLPKLWDLCESIHAWDKLERDTKGESLPFTSDLASACHRALSFRQQLLFSSPAQTFFRGGPLWRHVLLTLKSRISPGEKNILPLEIADIDALDIPIVSDSRLFAYFAHDSTLTAFLSHLGAFNNILPPYASAVIVELHRLVHGELALRFFYHNESKLSPSQLIPLTTELCGGKGAYWCPLEVLEDRLHGKAATDMENACTADETSSSSISLAASALAASILFAFVLPIGFIIRVLLCLISILLTYRFLFPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3S3</accession>
    <name>A0A0R3X3S3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7998</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020430">
        <property type="protein sequence ID" value="VDM32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3S3"/>
    <dbReference type="STRING" id="6205.A0A0R3X3S3"/>
    <dbReference type="WBParaSite" id="TTAC_0000801301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000801301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000801301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000801301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45664" checksum="53B1FDF1594A2F84" modified="2016-01-20" version="1">MLYWGYEKDGLIINDLYRLIRKIGCGSFGVIYLGVNQKNGEEVAVKVERNSARHRQLVYESKIYRILNGGIGIPRLRWCGSQFDHYFLVMDLLGPSLEDLFLFCARRFTNKTVLMLADQMLSRVEFLHRRCFVHRDIKPDNFLMGIGRHCNKLYIIDYGLAKRYCSWNKGRHIEYRLNSYCISIVLRDDKNLTGTARYASINAHLGIEQSRRDDLESLGYVLMYFNRGSLPWQGLRGNTKRQKYERISEKKISTPVETLCKGFPAEFAMYLNYCRSLQFDEAPDYLYLRQLFRILFRTLGHKFDFLFDWTLLKRHSEKPGASTAGGAVAGPAENLVEPPKTSQTNEAMATNPIESKSAQVDNLTGVPSGNNTPPVGDNTLLADLIDKAIKSYMDSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3T0</accession>
    <name>A0A0R3X3T0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centromere protein S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8006</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020431">
        <property type="protein sequence ID" value="VDM32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3T0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3T0"/>
    <dbReference type="WBParaSite" id="TTAC_0000802101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000802101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000802101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000802101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23259" checksum="767337A88E79DB9A" modified="2016-01-20" version="1">MPASESSSEPKLEQLSALHCECITRAKFVSDQSGVLISDEIASLVTENAFRFAQLLATDLEAFARHAKRSTINRDDVILFTRRNPLLRKFLDEKSATFDVASGEEDEGTKLQLLKRRARRSRTAKKSHDNSSMMSPLKTYFSPTDNTPSTSNVSRAAVSPLKRAFLESALSLTVSTPVEADRQQPGTGTPKISLLDSDDEFSSIFDDIGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Y5</accession>
    <name>A0A0R3X3Y5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020442">
        <property type="protein sequence ID" value="VDM32566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Y5"/>
    <dbReference type="WBParaSite" id="TTAC_0000808801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000808801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000808801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6226400at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000808801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22480" checksum="8E938174D2ADFBFB" modified="2016-01-20" version="1">MDPVSEPYSRYIRDRYLLAGDSGFHSADTMDERNDRWPPSRSTSPTSPSTDSYFREHYGVFFMDEDIEENSAKQTKEETKEESSDSTSQSSDEKGSIATSIHFPAVFVEGFCEGRVEFNIPGVMKDQFSPPDDINVHFKFPSDDSGQLHNSDIECLTKAGEVMTQWRKRKKTHSHFMATQHSRSQLYRSYFEGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X486</accession>
    <name>A0A0R3X486_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerol transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8194</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020461">
        <property type="protein sequence ID" value="VDM32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X486"/>
    <dbReference type="STRING" id="6205.A0A0R3X486"/>
    <dbReference type="WBParaSite" id="TTAC_0000820901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000820901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000820901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248360at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000820901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8086" checksum="E80930E50A46CF0B" modified="2016-01-20" version="1">MNPESVLRAGKLFQTSYGGDGVDFIDQLNYQYTGGLMVIFIAIIGVRQYVGKPPSLLLSTFLDLHLAWLFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B2</accession>
    <name>A0A0R3X4B2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020467">
        <property type="protein sequence ID" value="VDM32739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4B2"/>
    <dbReference type="STRING" id="6205.A0A0R3X4B2"/>
    <dbReference type="WBParaSite" id="TTAC_0000823801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000823801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000823801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000823801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75428" checksum="BC95E190FA764A38" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X513</accession>
    <name>A0A0R3X513_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8517</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020521">
        <property type="protein sequence ID" value="VDM33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X513"/>
    <dbReference type="STRING" id="6205.A0A0R3X513"/>
    <dbReference type="WBParaSite" id="TTAC_0000853201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000853201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000853201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000853201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41198" checksum="D6B77AE944572179" modified="2016-01-20" version="1">MAVDPGWMRVGSRRVLASFRGPTSCAYLFFIVVAGVTHVLWCPVVWRRCAAFSNGRFIFALVMNSFQGVLFRHLSRFQKACRFVRFVGTTVEEAEKKLNPRHFLLLLCPITAFSLGYWQIQRRRWKIDLMARMEKILPSPPIPLAEDVKASTDLPEFQPIMVEGRFDHSREVIIGPRVIITDDIPAGAYGSAWGSSPSAEHHTKESNLSDFGAPSPNGYCIVTPFELKDRPSVFILVNRGWVPTAFRDPVTRPDGQIQGIIKITGFIRYNEKPPPFTPAPKTMSNAGKDQQPHQQYFAREVIRISKALNTLPIFIDANYGSTVKGGPIGSQTKVLLRNNHTEYIITWFSLGALSLGMWMYWLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5L5</accession>
    <name>A0A0R3X5L5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8753</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020576">
        <property type="protein sequence ID" value="VDM33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5L5"/>
    <dbReference type="WBParaSite" id="TTAC_0000876801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000876801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000876801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256169at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000876801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="41953" checksum="3B0CFD0C2C7D7BA6" modified="2016-01-20" version="1">MSVFEMDRTLCNSPTGIQKEDPCKTKPTYNQGPGGGNNPCQQRSQFMPQQQINCYNSRQYQSSPYGGGTQCGQDYGRQQASAGGGGYCYGGQSSPANFCPPRQQQSPGNFYGGNMFGNPCQQPPQQAGGGCVPPPPPPPSANVTCPPDYCEPRDPTNTGPMALVNLTQNTAGLGFQSCQKGAKGGAESNACWGMGSGGRIGQKTVPEPDLSGNVEEKARQKAELKINALIRDVIGPEIQRKEKEIEDNEKANEQFFANYRAASAFKDGCLNASVFQRRPIKDIAVCEEDMVKRLKGMNSCGKEATLCPNFKDKKQALLNSISESYQYLEAYKKALERSNAALAPGCQRKNASFLQTTQSWIDNGLFSHEELACLVSKAQSAMNRCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5S8</accession>
    <name>A0A0R3X5S8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020600">
        <property type="protein sequence ID" value="VDM33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5S8"/>
    <dbReference type="STRING" id="6205.A0A0R3X5S8"/>
    <dbReference type="WBParaSite" id="TTAC_0000884101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000884101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000884101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000884101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11115" checksum="3DA1B3F42AF6F102" modified="2016-01-20" version="1">MYHAVAYGTMLHLQATATLEPSDLDEATSSIKYAVKACMKKRRKAKFADNFAKSTSKAKAAFYAAYSDGKTIAFQSLLSLYLLNNSSNYLSPQSGFVCSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5T0</accession>
    <name>A0A0R3X5T0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8828</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020600">
        <property type="protein sequence ID" value="VDM33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5T0"/>
    <dbReference type="WBParaSite" id="TTAC_0000884301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000884301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000884301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252482at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000884301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21950" checksum="A2369A2C8C22BDE7" modified="2016-01-20" version="1">MFTCHLSGANDVLKILNDNDGGGAMPYTDVHQDPLEFLRRWSYFQALWRSALSGTPLPEPLKERGSPGALSHPRHCSPTISQCSTSPVSSLANSTSTNRSFRTYQPVCLRLLTRRAVRGYVARAEMTRRHGASAALTPPLTVPALQRFLGYFHSLHHMLGAPLPPALQVLVSTATNIMDGNSSTLRSSEDATSPPELLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X671</accession>
    <name>A0A0R3X671_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8979</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020644">
        <property type="protein sequence ID" value="VDM33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X671"/>
    <dbReference type="STRING" id="6205.A0A0R3X671"/>
    <dbReference type="WBParaSite" id="TTAC_0000899401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000899401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000899401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000899401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39322" checksum="7F0A08EBA468F9A2" modified="2016-01-20" version="1">MILCDTNQIKGPRYPIYLPEKKLEELETTANALIVCGKGILATDETPTTLGVRFSSINLENTPENRRRYRELIYATDCSIKKYISGIIMHPESLNEQASDGKPMIELITNRHIIPGIKVNKEFVVLPGTFDECTTEGLDELARRCEEYYRRGCRFAKWRCVFKISAPTPSRLALGEIANVLARYAAVSQTAGLVPLIEPEVVAEGNHNITTAQRVYQEVLSHVFKALHDYHIFLEALLLETNFVRAGHTSCCQTSAEDNARTTLEVLQRTVPPAVPGILFLSGGLSEDDATMNLNTINTIESRKPWTMTFSFGRAMHNAVLSAWKGVDDNVPNAQCVLMRLARVRTNSVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6K0</accession>
    <name>A0A0R3X6K0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRAGA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9122</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020687">
        <property type="protein sequence ID" value="VDM33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6K0"/>
    <dbReference type="STRING" id="6205.A0A0R3X6K0"/>
    <dbReference type="WBParaSite" id="TTAC_0000913701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000913701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000913701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000913701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16629" checksum="300EDE837FCFF3B6" modified="2016-01-20" version="1">LSSSGYSYHGEADLVCPQQIGPNSSLFLSLLLHAVLDTAGQDEFSAMRELYMRKGHGFIIVYSVTDQQSFRQVRRFYTQILRARDRDSYPMILAANKIDLVQQRVVTPEEGQTLAQELGVRYIETSAKNPPVNVDLIFHDLIRIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6M9</accession>
    <name>A0A0R3X6M9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9155</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020696">
        <property type="protein sequence ID" value="VDM33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6M9"/>
    <dbReference type="STRING" id="6205.A0A0R3X6M9"/>
    <dbReference type="WBParaSite" id="TTAC_0000917001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000917001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000917001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000917001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21660" checksum="19EC57A610B6E08C" modified="2016-01-20" version="1">MVRKLRYHERKLLKKFDFINWSADKNLNELKVMKRYYIQKREDYTFRYNKLSRRIREIANKLKDIDGKDVWRAEMTKMLLSKLHNLGLVPTKSSLILASKVSASSFCRRRLPVVMVRARMAETLKAAVTFVEQGHVRVGPDTIRDPAFLVTRPMEDYITWAPGSKIKKKLQEYNGILDDFDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6S9</accession>
    <name>A0A0R3X6S9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3694 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9215</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020718">
        <property type="protein sequence ID" value="VDM33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6S9"/>
    <dbReference type="STRING" id="6205.A0A0R3X6S9"/>
    <dbReference type="WBParaSite" id="TTAC_0000923001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000923001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000923001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000923001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46337" checksum="6DC6C366D4FA0DFF" modified="2016-01-20" version="1">MLDNHRYGSSTDAHGRNVLSSPLYIPSAFNTPRLNDAVGDFGEIREKLVQANLLAERANALLKERRSNVRYHVSLQVPIHCLNQAKREHRQLQCEPVIELHRGGVRERSLSLARMQYNLRELESNQGENEDSGVSLSGSSNLTNEVKLLGAALIRSFFKVSGRINVELSTTIRLEDSRSERSSESAGVVDLLDRELCDFGGNVLEVRVAIHEAIGVPHSFGGMILCHYQMLGLEEPIVVLPKRESFSGQTPPDPTTREYERTERCVFDHRRVFHLPLNRQTLNSLADYALSIEVHGSLQEPKSSTIIRRITTNRGPLHLNTNRQVADQQHQRTNSPPQIRTMKLRRYKSDLADKRKPTLQGSHTLAIGASPTSGLPNEVATRLAEDWLRVQRRLDFWVAIEELMEDLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6V6</accession>
    <name>A0A0R3X6V6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020730">
        <property type="protein sequence ID" value="VDM34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6V6"/>
    <dbReference type="WBParaSite" id="TTAC_0000925901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000925901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000925901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6228672at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000925901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123175" checksum="967AD3F21C948D36" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7N6</accession>
    <name>A0A0R3X7N6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9546</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020884">
        <property type="protein sequence ID" value="VDM34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7N6"/>
    <dbReference type="WBParaSite" id="TTAC_0000956101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000956101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000956101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000956101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15663" checksum="9480912D66C6CBC1" modified="2016-01-20" version="1">MRLDLVLHAVMAFNFKLLESLPICRDFKAGKCHRNTECRYVHLIDENVEVNQGRVTVCRDAAKGRCTRIPCKYYHIPLIAISASRSLALNSALSAAVAANAFTNTAAGTVAASPGTAATSTSSLTNGTSNNPLPSQPPSTSASLTKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7X6</accession>
    <name>A0A0R3X7X6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9636</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020948">
        <property type="protein sequence ID" value="VDM34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7X6"/>
    <dbReference type="STRING" id="6205.A0A0R3X7X6"/>
    <dbReference type="WBParaSite" id="TTAC_0000965101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000965101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000965101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000965101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="931" mass="101076" checksum="EC34CE7CEC60066D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Q1</accession>
    <name>A0A0R3X8Q1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4283 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021152">
        <property type="protein sequence ID" value="VDM34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Q1"/>
    <dbReference type="WBParaSite" id="TTAC_0000992601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000992601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000992601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000992601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23658" checksum="99765E0507CE6BE5" modified="2016-01-20" version="1">MANDGSNDGWIYASACEDDGRHDVEFHPVLATGNAGRGASFAVCSTGIVTQTCMEVKREEEEEVKRWVMMMVVEEEEEEEVKSFMQENHLQGPFFQSFVNVNFLKGDNIEIIVSDARFSETGHYYREGKLTVVWIRKKVDRDIRELDGGFVGTLATLCLSRLLDYLAGAMEDDRLVSQVPSPVENVYVHWAGAWQVEVEVDVGAHLLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8S8</accession>
    <name>A0A0R3X8S8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9938</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="function">
        <text evidence="1">GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021174">
        <property type="protein sequence ID" value="VDM34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8S8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8S8"/>
    <dbReference type="WBParaSite" id="TTAC_0000995301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000995301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000995301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="78"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000995301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24489" checksum="37F2596E610365CC" modified="2016-01-20" version="1">MTKCPHSGPIKLILAHQKFDYIDEPIKVKDWQLRREEIITARVPALCIHHRDGRVEWMTEAAAILRCLGKQYNLLGRTDMEAYHCDRIIGKVMESGRILAGFYKTRKFHDSDMHEQEEYKEKFFEKMSVVLQASLTHLDRMLKEAPGSYAAADVITIADFYLLDFVDFLKANRPECLNQFPYLQKWRKHLLETDQPVAKFTASRSWIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8W2</accession>
    <name>A0A0R3X8W2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9972</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021204">
        <property type="protein sequence ID" value="VDM34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8W2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8W2"/>
    <dbReference type="WBParaSite" id="TTAC_0000998701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000998701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000998701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000998701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11789" checksum="45FCBDAD88597A24" modified="2016-01-20" version="1">MNTIQWTINTMLPVRRVYYIKQYLKALRLISSTEERDCTRFVNQNLGADGIFILHIVSKIASDLIALDVTATLWKNYRQAKITGTEEDVNRLLETVNRGSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Z0</accession>
    <name>A0A0R3X9Z0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrin_b_cyt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10350</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021583">
        <property type="protein sequence ID" value="VDM35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Z0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Z0"/>
    <dbReference type="WBParaSite" id="TTAC_0001036701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001036701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001036701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="4">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001036701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26102" checksum="CCF111922BC687F5" modified="2016-01-20" version="1">MGVCDCGQCFCNSGRTGQLCNEVQGGESALCTDRGVEQCVLCLRREMLGTDEAKIAEEAEKRPPYAPPVTVSSEAVAACQAVCNTTVIDTNKVQIIDEVEEEGKEDVGEGGGIGGGSGSGTNLCIIYTEDSCRVMFKYRYSDAVYINRKVDLKIVRKSECTKTTGILYIILGVIAGIVLGGLILLLIYKLVITIDDRRELAKFKMHNENVHWEMAENPIFEPPTTRVINPTFADDTAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA03</accession>
    <name>A0A0R3XA03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10363</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021594">
        <property type="protein sequence ID" value="VDM35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA03"/>
    <dbReference type="STRING" id="6205.A0A0R3XA03"/>
    <dbReference type="WBParaSite" id="TTAC_0001038001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001038001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001038001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070760at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="240"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001038001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46777" checksum="64271CE26BD0A580" modified="2016-01-20" version="1">MASRTLESALPVLQDALRFQISTLSEDLRLGGFTHRRVILSQLPSPTGMTQEQFEYIWMSPEGQPMTPQPSPEIYVHLKSPQQFGVYTIRVRGTRSGYTHELQSDVLLQSNPDGYSLWILGQREAVLPNSRVDVLCEVRPTHPGAKVRWVNAQNLMVAPNNRLVIERFGSYNEGSYYCEAFLPDGTILLKKFSRQMGIETDIFESGFVGDGSNSYAVHIVRYPSHFFYNNEVQLHCIVQPDVSVHIVRYPSHFFYNDEVQLHCIVQPDVSGVTFEWTKDGKVVGNDQVLDVPAFGRQDVGKYQCRATIQSVVRIAEEMLTPSSEDPKNDFELERQGLTMEPRVVNSSAFKPFELECIAHRPDVRPLVVLSSGANITLDGHFQLRFPDARKVIITVPRGLPTVYNGMSVRLVECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB92</accession>
    <name>A0A0R3XB92_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10802</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022262">
        <property type="protein sequence ID" value="VDM35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB92"/>
    <dbReference type="STRING" id="6205.A0A0R3XB92"/>
    <dbReference type="WBParaSite" id="TTAC_0001081901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001081901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001081901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001081901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38997" checksum="D7513DD6F129F154" modified="2016-01-20" version="1">MYSPSSQTPIGILQETATKRGFLVHYELVASEGEAHEPIYVYQCRVGKITAFGKGASKKKAKHLAAYYVLLRLIGDDPPSQGDRALLQAMRASLSFLGIDVGDSLAVTCEDEVNAAATRAPVNYVSKVQEYCDKNLWPPPTYEFSECSQNLFGGKYHCKIRLWRWEFSGFGSSKKEAKRKAATEFLKEVVEQGLTIPTDALEAMEEENLPLVEKQDLNKLKVKQSSQEMASRMARKILSGLHTANGRVKEIHVEELNSPDFDVYDVLKRVLEANKLGVFYSYTTNTKSGSIYCQAQLSTIPPHVTCSRPSASIDEARRDAAYRCLVYLDTMTKPNPTLCEEAWFRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBT6</accession>
    <name>A0A0R3XBT6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10996</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022697">
        <property type="protein sequence ID" value="VDM35976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBT6"/>
    <dbReference type="STRING" id="6205.A0A0R3XBT6"/>
    <dbReference type="WBParaSite" id="TTAC_0001101301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001101301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001101301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="212"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001101301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38916" checksum="63951FEA721D917F" modified="2016-01-20" version="1">MFDSNVCAIESLPLKDITVEANINNFFVDVSTKYSYENNSNELLESSFVFPIESGGVVYEFEVFVGDERFLGVCRERNEAQFIYDEGSEKNRTVFILLEDEEMTDVFSMKIGNIPAKEKVFVRISYFLKLTTLNHLVGVSREDEIITIFSLPVLVNLRYSPKKDFQMEITCDNASTFSSLECSSERSGFFSADCVLVNFFSQIPFPYRPNAEIIFIIDRSGSMDGDPIQQAAQSLLILLKSLPSKCRFQIVGFGSTYKMLFPEPQANTEDNVSTALEYQRNLSADMGGTEVLSVLTAVYASKMTGSADHWRREIIFLTDGGVVNHAEVSQTLFISFIFQQIRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC23</accession>
    <name>A0A0R3XC23_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11083</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022904">
        <property type="protein sequence ID" value="VDM36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC23"/>
    <dbReference type="WBParaSite" id="TTAC_0001110001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001110001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001110001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001110001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="8807" checksum="B7F9957F1BD2EE02" modified="2016-01-20" version="1">MGARWTALSGSKALVRRVTQTGDEVRLVVAPLPPHLPSRIHETVALVLDDYADPAAGNNFGDTGVAPAVGAGTDGGCVGTGRGCSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC27</accession>
    <name>A0A0R3XC27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11087</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022920">
        <property type="protein sequence ID" value="VDM36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC27"/>
    <dbReference type="STRING" id="6205.A0A0R3XC27"/>
    <dbReference type="WBParaSite" id="TTAC_0001110401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001110401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001110401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001110401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43223" checksum="A0DE2732C23B2E47" modified="2016-01-20" version="1">MEPLSSRAQKRVVLEGLLEESEVEDDAALLSGDLTAIGLVNPLTVALQTVATQVSRLQDARNWVKSMAGKLDTLIQLLFRELLCFGRVQMLTKEWWNVHDETEQFVVRLQATSPTDMAFIKPEDVESQLYQHSVDALANWTTLQGRLSHLAFLRNALQQHHTASTTLECPTCLQAQSPSRPTFVLLPGCWHSLCLPCHQRIQAHSVSSQRRCPLCRKPFETAASNATKRRPLTLLHFDGGRKLQSKQKEEQEQEETKDEIPIKGDHSSKIQEVIRCLKRIKLEDAGAKAVVFSSWTSVLLTIGRALELNGIICTSLLKPRDSGLAQFRSAESRVWVLLLPLQLGANGLNLIEANHLLFVDPVLSHGREVQAIARLHRIGQLRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC36</accession>
    <name>A0A0R3XC36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11096</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022947">
        <property type="protein sequence ID" value="VDM36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC36"/>
    <dbReference type="STRING" id="6205.A0A0R3XC36"/>
    <dbReference type="WBParaSite" id="TTAC_0001111301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001111301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001111301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6019271at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001111301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21483" checksum="ED0CCB24BD232402" modified="2016-01-20" version="1">MCPEFLNLNAEVFMRLFHAVQHPLKCEGCKREPIVGLRYKCTRCPRYNLCQDCFWTGITTDPHTNSHDVKEYTSATYRLYRPGLPPQMLQSGGMPPTFYYSVPGPGPTAIARPPPTPVMQTRAFHRAASVPLQSQAPLPPPPPAPQQQQQGVFAPGFNPTTVQPLSPLARGKITSNTYGKTHRTKTHRKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCX4</accession>
    <name>A0A0R3XCX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11384</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023869">
        <property type="protein sequence ID" value="VDM36364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCX4"/>
    <dbReference type="STRING" id="6205.A0A0R3XCX4"/>
    <dbReference type="WBParaSite" id="TTAC_0001140101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001140101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001140101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001140101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11266" checksum="145EBBF524AC13B4" modified="2016-01-20" version="1">MRQLWTYSDPSTGTDEGFGITALKWSRANPLTFFTATLAATVVGWSAANAGVPLVVWRGHSEAVLDIALSLPTGEPPREEFIASVSDDETVRIYDMTEVTAVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCX9</accession>
    <name>A0A0R3XCX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein CASC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11389</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023888">
        <property type="protein sequence ID" value="VDM36369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCX9"/>
    <dbReference type="STRING" id="6205.A0A0R3XCX9"/>
    <dbReference type="WBParaSite" id="TTAC_0001140601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001140601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001140601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10610129at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001140601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23552" checksum="75B96261431FBF5A" modified="2016-01-20" version="1">MTCRTLSNTDFGFAQGTSEGALTKKKAKEGLDYLHSDEDQEVPYQPNGGPIESGEYIDFRLYDMWDRSELPSPTERYYNMPTYEVSDEESTTKSDEQAEQLKHRDTSGCLETQNEAFEDALPDENYLKIGKIYRILDDPMLDVQGAEWSSNPGFQGGTPDNVKTDSNCEDSDIISEQKKYQRKYKTAERARERLDPQLLANVPRCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REM9</accession>
    <name>A0A158REM9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing family member C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7620</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REM9"/>
    <dbReference type="STRING" id="6205.A0A158REM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000763501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000763501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000763501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000003">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000001">
        <property type="entry name" value="EF-hand domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="75"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="411"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000763501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="763" mass="86824" checksum="76D4AD653A356975" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RER0</accession>
    <name>A0A158RER0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="24">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TTAC_LOCUS7846</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020412">
        <property type="protein sequence ID" value="VDM32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RER0"/>
    <dbReference type="WBParaSite" id="TTAC_0000786101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000786101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000786101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68108at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15734">
        <property type="entry name" value="FYVE_ZFYV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042427">
        <property type="entry name" value="ZFYV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624">
        <property type="entry name" value="AGAP002036-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624:SF4">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="21">
        <location>
            <begin position="486"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="21">
        <location>
            <begin position="640"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDM32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000786101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1284" mass="141666" checksum="1E5472B9E6DB8FCD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REW0</accession>
    <name>A0A158REW0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8159</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020456">
        <property type="protein sequence ID" value="VDM32665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REW0"/>
    <dbReference type="STRING" id="6205.A0A158REW0"/>
    <dbReference type="WBParaSite" id="TTAC_0000817401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000817401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000817401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000817401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40223" checksum="9D57BD724DD5C8E5" modified="2016-06-08" version="1">MSNKTLFGKSLDKYDSNIDDIDELLSKLTEAEIKELNDDIDPDNSLLPPSQRCRDQTTKAPTGPFNRENLIKFLVEKAKNDPDWDEAVPYEKKIRGKVFEKKKVEPTTAEKNELSELGFDVEFDESINEALNNATDDELIDLAAILGFTGMMNQVQFHASIENRGQVGGGFSGVAKAEQLKIVPDEPPNMTDVEDGIKKITADDASLTVLNLNNIKNLDADVVSRLFTALGENTKLRELHMAGTDLTSAMVEPLLLPLKVNHTLEVLNLESNFITGDMILKILDSISDPKSAIKDLRLANQRQRVLGVQVEEEITKLVLQNPRLNNLSLYLDTPHARVQVNEHLKKTVDANKRLARVNKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EF79</accession>
    <name>A0A3P7EF79_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001019">
        <property type="protein sequence ID" value="VDM19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EF79"/>
    <dbReference type="OrthoDB" id="5850793at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="223" mass="24723" checksum="49717A7C506D0F68" modified="2019-02-13" version="1">MPSIIAALRSSGDATTTDAYLQALQRGLRDLTCTSKSGEHVVSPSTRRECPACRLKRCFLIGMRPDLIQVRKKDGTKPRWLDKYPAAAQVHEHHVARSEVSKMSRLKQNSSPGDNSHRDPYPLTYPHYTVTPHQLNNGQSMKGGRGFETFPPEAAYATPRSMMPSHPLPLTPVLQNNGGIYEENGRSVSAVLSGEADPVLSEFQVKTELSSPQYRSPAYCDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EJI2</accession>
    <name>A0A3P7EJI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002791">
        <property type="protein sequence ID" value="VDM23051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EJI2"/>
    <dbReference type="OrthoDB" id="5915660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="304" mass="32596" checksum="10C63A1734FC57F9" modified="2019-02-13" version="1">MVQIDGESFHLILMPAYLPGGAHTLRQMRSALLRIFQTARDCEDDRKNSNSVASGYGSERQDELLQALNSMEGRTASLLRDLQASPTFVNPNSCSTDSQPNSSTSQAFTGPTGGSAGGLDPIGGGSSLDLLAYDHLHSQHLIKSENSFLQPFSGQTNEYHRSRLNYPPTLTTPLDSAHQQRVSGCFDNHTSGNDLSTFNGISMDSSTAAAYAMMPSAFQSFRDNDSIHHYQPNVFITSSQNTVNSSGSSVVISQDNNGALVAAFGAAVSSSQSSGKLFEEIANSRQQQCHQTSGTDVSMVRDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FBA1</accession>
    <name>A0A3P7FBA1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005622">
        <property type="protein sequence ID" value="VDM25847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FBA1"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="188" mass="21267" checksum="0AF6702381899A49" modified="2019-02-13" version="1">MPWALQLNALIKAFRTPVNARFPMKKFKGNRKYAFLEFSSASLAKQALERGMQLKFLGRTPKCEVVSQKVQNGYLNDPWIYQLNDFKLNKLMISCIPRIATVDDIRYLFPGASNVDFPNAGPDKALGSAQVEFIEAKDALAAFKTKHGVLIHGVPIIVNYCLRKKAGKRNKEERKNANGEQVRLHTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FMK8</accession>
    <name>A0A3P7FMK8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARF GTPase-activating protein GIT1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020609">
        <property type="protein sequence ID" value="VDM33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FMK8"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF GTPase-activating protein GIT1 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="80" mass="8311" checksum="11EDD1877D1D4BF1" modified="2019-02-13" version="1">MVVLFPPISKCHLTVGAALTSLMANSQKLRLHCEASAVAAGTESPGSAASGTNSSQLITFAHEIASAAKTILNFFQAERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FSS7</accession>
    <name>A0A3P7FSS7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS7442</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FSS7"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM31819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="390" mass="42635" checksum="095BF9AFA92EB07A" modified="2019-02-13" version="1">MSISYSYFFRVAELSPLHRKIHKSSYLNVIRTINVPSFPESISDGDVSWKKSVGDAVQVDEVVAEVETDKTSIPVISPVNGVIIELLFEEGDKVTYDQPLVKIDEREVALGRSSAAEESSSLSLTDASTPAPLQAEGDSESSFSPLSAASVVSPPRPSHVAGPTSFSPTFARTAERLKEAQNACAMLTTFNELDMSNLIDMRAQYKEAFFRKHGVKMGIMSCFSKAAVFALQDQPIVNAYIDGKEIVYRNYVDLSIAVASSKGLVVPVLRNVESMDFAAIERGLFELGEKARSGSIAVEDMDGGTFTISNGGVFGSLFSTPIVNPPQSAILGLHGTFDRPVVRNGQVVIRPMMYVALSYDHRLIDGREAVLFLRKIKSFVEDPRVFFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FTE2</accession>
    <name>A0A3P7FTE2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022253">
        <property type="protein sequence ID" value="VDM35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FTE2"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="503" mass="59037" checksum="C7F333C7D74A68A2" modified="2019-02-13" version="1">MPFLKLSHSPFTHQLERKPPAEIKNALLRWCQLKTASYPQINIINFTTSWSDGLAMCALLHRHRPQLLDFATLASTSTSPIKRLAKAFTLAKAAFQIPTIINPADFIACCNDEQCVVTVVATWYYRLNEARGFKKSVSRLAAVLDRAVASSRRMMEYVLKVTALRRWMKTNLRYLEDLTNGIDTHQISTKLTMWRESEKKAKMKDLAQIEFEWLLLRMEKVAWGYSSPSPAPRFAYPTVYRIWKQIDEAEMECVRRVCRDFEVQSQKRQLLDKFYKKVKLHKHWLLECNHMVELAAQRDARGVQSSLQTNPKDGYLSAAVINHERGLVQRSVERNALMRVDAEVHHNQKMQLLLHLHPTDLILRQIHKHWNLLTDTFHRREEGLLTQLRCLDRLHELTSLREEMEAIWRRVSTLHPPESSLHLWKARALIAADKVASRPVEWTFIDQTRNECIFSRCYSQFWAVNWTVQCILLCYHKFFVKVEHISNLQRRICNSLAIIKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FUD6</accession>
    <name>A0A3P7FUD6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">26S proteasome regulatory subunit p40.5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020421">
        <property type="protein sequence ID" value="VDM32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FUD6"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="165"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="374" mass="42679" checksum="EC396C102C81F71B" modified="2019-02-13" version="1">MLGMEYLDARIKNSKSFRDDWTHIRDLYSRKLWHQLTLQVLESLNKPGFTASLDLNEVVIDLIDMIGNDRINPLSLAEILVPMSNEMIRKAQLNFWRIIGTNMNDEALILAQSTIGMVRLLVLHDLPGARDIIEATGDILSKIDGVTPVHSRYYRMSSQYFKVNIDFGHYQEALRFLGCTDLSELSESEKQDWAFSIGLAALLGRNVYNFGELISHEILETLRSKPDMAWLVDMLHAFNKGDLDTIMQLRPQWSAVKDLAEACELLQEKAILLALMEMFFRRPPNQRTVSFAEIAAATKSPLDKVESIVMRALSLNLMKGRIDEVNQKVTLTWLQPRVLDLDQITSMANRLTEWQKSVTTARDLVSVDAKKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GEI3</accession>
    <name>A0A3P7GEI3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein zer-1 homolog-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001521">
        <property type="protein sequence ID" value="VDM21198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GEI3"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF22">
        <property type="entry name" value="ZYG-11 FAMILY MEMBER B, CELL CYCLE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="368"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="475" mass="54215" checksum="6EFD0D3C4837AA1B" modified="2019-02-13" version="1" fragment="single">MEDICVRWITKNLNQVITKCSDCIEPKYVWRFPYPDCRIVARPAEKILLKLCKRQILRDDYLSLFSVKYVDLVSPVLRDVSVSPSTLRVLRDFKLYNLTATSLKQTSLNSLISCLSEASAESLVSLNVTNTAIEENKLPVIISLGRLKNLQALNVSRTKFTTECLQNAVKLLPRLRYLNISRTNINNISALLDLRDTLTGLIMHRLNLDSRQVLERVLSTVLELKELRVLDVSSASDRDKPRLPAVDRLCAPGALPHLTHFDICGNQFSLKLSDVRNFIANHPNLEFLGLAAWPSRQNHELEGIYQLSLKYPNITMLGDRGEKPLLNTLTRNKDRRIYLQNAFHNIFEETISREWLNPDLLAAVLRVMRLHMNKQDMILAGTAVVYNLTRGEQSAYLPLELLNRAVSITLMSIEHHQGQVQLLKNCFLTLCSDNVLHRAQFSCKRCCELVFRSLIKFNDIHMKRMGVAIISILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GGJ0</accession>
    <name>A0A3P7GGJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001333">
        <property type="protein sequence ID" value="VDM20775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GGJ0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="107" mass="11669" checksum="43BBA53DBCD8E5D6" modified="2019-02-13" version="1">MATVNHGMHHDVHNLTFRPPLCHTGAAVDATAAASCTPLSHHHMALDQPKCTTTAVLHSTSQHFHFHVLLASSHACTYYSPTVFQCEGIVRTHHSTAISLQKMARPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GMK6</accession>
    <name>A0A3P7GMK6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003067">
        <property type="protein sequence ID" value="VDM23392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GMK6"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM23392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="122" mass="13613" checksum="E04A681A8B4DECC4" modified="2019-02-13" version="1">MMNCSNSDMTRLINDATVAFNHQQLPRASSRDLRRQSLGYGFVNYANASDAEKAIKHFNGMQLKNKKIKVSIARPSSESIKGANLYICGLPKNISQEDLEKIFSRCGKIITSRLLVDPTTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GTR7</accession>
    <name>A0A3P7GTR7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004841">
        <property type="protein sequence ID" value="VDM25245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GTR7"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="80" mass="8941" checksum="0F639C60F3F460B9" modified="2019-02-13" version="1">MGEKPAKEVKAMMSMKRKLLQEANGSTPMVELFGPWQVEDYVPPVAENGIVPRNEHGNVELFKPCMLPIGCVHVRLADLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GUG0</accession>
    <name>A0A3P7GUG0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006307">
        <property type="protein sequence ID" value="VDM26308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GUG0"/>
    <dbReference type="OrthoDB" id="10065050at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19880" checksum="55988B9DCA6ED890" modified="2019-02-13" version="1">MLVGQEWADRRLQPTYHLNARGQAIHLAVLHDLAVSRPHVVYAPHVWPLTALMLHYLRPRTALACIRALLDAAPDERVAQSKSLWRSRCLALEALLDSKSSALLHWSLLNLSPVEEEGGGRGKVGGKKKESAKQKQSDALAAWPIAVWFVPFECLVPIVDCFLAEGVKVLFRMGFVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHJ1</accession>
    <name>A0A0R3WHJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000000401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000000401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000000401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000000401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36055" checksum="49AAEA29D2E9529E" modified="2016-01-20" version="1">MSQFGLFYEGVRWDIPSEGGAACLSYLSKTRRLLETLFFTFVYGISLLWCIPRLKLPVDERYTPRKRIAWIAMVHCLVFGMEVGYKLTARSLIFIFNPCHAITAVQIWLLCAKPSSFVTAVFRLHLHGINGTLLALLLPTTGTRTPALRIIYFVQHILILFVPACILDQKSVYSIEPLGDFNWVLTSLAIQTLYHFLFLQPLGMLTHANLNQMLCPSPSDPFAGPHYRIAAMIHQPLLILLSGKLYSIIVLWLQQSIKSPNFLKPLCSSFHWLPGLTIISRNPTKAVADQIVCEKTVERRPRSLEELFQTQSSCTTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIQ5</accession>
    <name>A0A0R3WIQ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS495</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000044">
        <property type="protein sequence ID" value="VDM16528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIQ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WIQ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000049401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000049401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000049401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256987at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000049401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10648" checksum="F58F6A5361B3352B" modified="2016-01-20" version="1">MSHHELKWFSNYCTALVAFMQADADEMGGSGGLDLTQSLKPPKSLLLEVRCLKDYGEFETECGKVINLTKGSQHQMFRSDCESLILQGILQHIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIS0</accession>
    <name>A0A0R3WIS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000046">
        <property type="protein sequence ID" value="VDM16560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIS0"/>
    <dbReference type="STRING" id="6205.A0A0R3WIS0"/>
    <dbReference type="WBParaSite" id="TTAC_0000051001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000051001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000051001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000051001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23789" checksum="18085E1D4AE9A4A0" modified="2016-01-20" version="1">MSINTAHTHDGLGVAYYPVLQFQTSSYSFWFGSTTKWKILGNCIPYIVIFLSKDKSPALNSLSMPFVYMKRVAIKQPTFGPNHIEGFVSPESGQWSGDLPFKLVFNHGGAIEFGKSLLELGTRASKLRESYKTPTAPPLCEIYACPPPAYTPFVHETYPLFAVDFLYQTNSPPPYPGAVPPPYTPNSGPPPPYAAAAAGSIPPYPTGGPPPGRSGYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIU1</accession>
    <name>A0A0R3WIU1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS542</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000052">
        <property type="protein sequence ID" value="VDM16610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIU1"/>
    <dbReference type="STRING" id="6205.A0A0R3WIU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000054101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000054101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000054101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000054101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="57340" checksum="02B00A59B6342972" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIU9</accession>
    <name>A0A0R3WIU9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate cyclase-stimulating G alpha protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS554</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000054">
        <property type="protein sequence ID" value="VDM16636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIU9"/>
    <dbReference type="STRING" id="6205.A0A0R3WIU9"/>
    <dbReference type="WBParaSite" id="TTAC_0000055301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000055301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000055301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6231739at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101094">
        <property type="entry name" value="Staphylocoagulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="189"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000055301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55812" checksum="0583DB0332E1B8F6" modified="2016-01-20" version="1">MDCFSSEDKRRNDYFLRIMQQHGIENRSVHRILLIGTGESGKSTFVKQLKLLSSPHGTFPEAYRSKFLTEIQRNIIQALANICTFMIAEGIPLGNSHSEEMMDLQRKIIKIHEEVRINPDSVAHYTVDADSATRDKFFDMCESLWSDKAVQATQERGNEFQQIDSAGYFLEKLNVLRQPDYLPNDKDVLQCRTRTLGIHTESLVYNGIPFELVDVGGQREQRAKWIEAMTDGVTAVIFLTDASAYDTMLEEDHSVNRLRESYQLLGQVWTKSLLKDKSFILFLNKQDKLADKVRSEKSPIINFFPEYKKGQVKFTITFLSELLIQKKRKKDEMEVWKKHFSYFLPAASNAVLGMQKEKEAMSMEEIIMEEYNEVQTTLNKVLHGEAVTTWPLTGDVRDSTIDTLMNDIEFVQLFHKLMSVALYRTVTVTHFIKTLFLAQCEETKMRKIYPFPTTAIDKRNVIRVFDSCKEILQGKALSDMIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIW4</accession>
    <name>A0A0R3WIW4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS571</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000057">
        <property type="protein sequence ID" value="VDM16666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WIW4"/>
    <dbReference type="WBParaSite" id="TTAC_0000057001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000057001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000057001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="1383"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="15">
        <location>
            <begin position="2123"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="690"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="792"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1529"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1560"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1696"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1773"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2049"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2086"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1534"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1787"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1826"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2096"/>
            <end position="2105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM16666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000057001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2446" mass="267281" checksum="B3791545411F2D7E" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK86</accession>
    <name>A0A0R3WK86_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1122</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000188">
        <property type="protein sequence ID" value="VDM17497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK86"/>
    <dbReference type="STRING" id="6205.A0A0R3WK86"/>
    <dbReference type="WBParaSite" id="TTAC_0000112101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000112101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000112101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000112101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22253" checksum="015ED967004EF7FD" modified="2016-01-20" version="1">MAEDRVSAFLSREKENLGDLTDELFNGTGNAPDFAEGSKGDTDLLSESEESQKIEEPPLTGIESTFCLTGQHINGTSQKKVSIQSSVTRGQESAILESWRANFEADIKARDEREVSKRTELEANAKKELETWYAHYRQQMALRSADNRADAPRDASGKAYDGFSGQAPSVRDTAVWESVCCMCDLTVSLSAFQQFIGVHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL91</accession>
    <name>A0A0R3WL91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1516</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000354">
        <property type="protein sequence ID" value="VDM18135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL91"/>
    <dbReference type="STRING" id="6205.A0A0R3WL91"/>
    <dbReference type="WBParaSite" id="TTAC_0000152901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000152901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000152901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000152901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30522" checksum="2E1D36D18321753A" modified="2016-01-20" version="1">MIVGLHVEELVGYQSEPCTDHELATATQCFRRIPDAVYSLPSGYTVLLHCIVENMRGKAQWRFNNLLLGHDRNVPGFERISMPGDPNTGDVSLQIRNLTVSDTGEYECQVTPSMNHPLLRRKTWLQVTDGLASCFAPTLVMPSIPRLFALGKEVKDRSLVVPLPDEEKTITVECVAPNGIPPPDFYWKLNDVLLRSMPTDVKSPVKWPQIVTNQGEDRSLVTLLKSDLKTGDNLTCEVSNNATLAREDLTARTLRTTTLFDVHGELNLGLRVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLF9</accession>
    <name>A0A0R3WLF9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1584</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000388">
        <property type="protein sequence ID" value="VDM18247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLF9"/>
    <dbReference type="STRING" id="6205.A0A0R3WLF9"/>
    <dbReference type="WBParaSite" id="TTAC_0000159701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000159701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000159701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000159701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37526" checksum="08FB66E147AE6AE3" modified="2016-01-20" version="1">MSDMEICSETERSIDNKETEEAFLELAQDIFNPTQKAKVVVCFCQGETVAGLLRAMDTLHLQGKGYMLIGADGWSDRQDILGPLINPKTGERAFSRLAQGSLSIKLHSPEVKDFDEYFTSLTPQSHHNVNPWFTEFWEQKFDCSIIPSSDSKRKPCTGNESLKNLPFHQDNKLSRLNLAIYVVALALHRVQEIVCGVGRPGLCPGLLPINGSLLRQELLKSNFTDSNGDTIYFDENGDPPASYDLMNYQHYFNERGEEVFDYVQVGRWQHGHLVMLQDEFIQWQSDLANATASGPIQSFCSDPCGAWEAKVDTFWRTAFFTKDNLAHLIFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLL5</accession>
    <name>A0A0R3WLL5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1640</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000421">
        <property type="protein sequence ID" value="VDM18327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLL5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLL5"/>
    <dbReference type="WBParaSite" id="TTAC_0000165301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000165301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000165301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000165301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22027" checksum="655CBFAF197527E6" modified="2016-01-20" version="1">MTTSPAYNPEVLLQQASMSNLQRVFVQRDFTEGTAVRFQTSLPERLTGKASIFSGAVSLNWMPALNLSFTLELLFAGLLYLKAIDWVLSLTIRRIPPEEFAKAISDLNAMFDKAEALTPGVVCENLTGCLTAYLLFLCMPTHYERMLDKIAYRVIQLNDQIFMPHGLLMIDPAERGLRMIEICILNSTDSNTSQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM54</accession>
    <name>A0A0R3WM54_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1829</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000540">
        <property type="protein sequence ID" value="VDM18569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM54"/>
    <dbReference type="STRING" id="6205.A0A0R3WM54"/>
    <dbReference type="WBParaSite" id="TTAC_0000184201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000184201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000184201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000184201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40631" checksum="3D1050F25ECA8ADB" modified="2016-01-20" version="1">MSAVGCFCDYECHASNDCCAAVNNSLSPLSFEENAVPSACLSVENVFLDDIILPRGNYVSAFTHCPSEKTIDEEVKLGCEEANLMLLASREENPLQWLRAHARSIVPVVGFRDRRLYGNIFCAICNGQFQDQVYFSPIHLGCRKEGNITECLVSVKLPASFSRPCTPLGPRAFMPRGMFLSMDDLFIIPEEYLNNQYIDLPLNFEKNENINNNDTKTMDSNASSNVVYDRDNSDEAYVWVQLALLIFSVVGLTLMLVVYGVNANLRRSLAGILTMGLGVALLLMEVTFLIVAFAVPEVKNRGFCVCMVALLLYSLLCSFTWMTLFATQLLVTFGNCRNCILFCWKFLTCKWSAKTVRNCEMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM63</accession>
    <name>A0A0R3WM63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Not3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1838</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000546">
        <property type="protein sequence ID" value="VDM18578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM63"/>
    <dbReference type="STRING" id="6205.A0A0R3WM63"/>
    <dbReference type="WBParaSite" id="TTAC_0000185101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000185101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000185101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="586"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000185101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="696" mass="79118" checksum="AEEF1470A9153800" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMM7</accession>
    <name>A0A0R3WMM7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2002</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000677">
        <property type="protein sequence ID" value="VDM18742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WMM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000201501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000201501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000201501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="10">
        <location>
            <begin position="631"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="759"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM18742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000201501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="919" mass="102371" checksum="3051A0A60DC04CAB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN64</accession>
    <name>A0A0R3WN64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2189</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000836">
        <property type="protein sequence ID" value="VDM19179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN64"/>
    <dbReference type="STRING" id="6205.A0A0R3WN64"/>
    <dbReference type="WBParaSite" id="TTAC_0000220201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000220201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000220201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10005492at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM19179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000220201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49320" checksum="9F2A7D7225632C35" modified="2016-01-20" version="1">MEVASAIPYTAMLTCKICVSKRAKYTCPRCFINYCSLNCYRDRRHGKCSEQFYRECCENAIRGLAVDDERRHQIERMLSQDADLCNFNNVEYQSEESEEESSSEDDPGDLSERLKGIDMTSGDIDTEKVWELLSTKEKREFHRLLATGNIYAIVPTWTPWWQSAAQKLVTSFPDDFIDASESKPINVAAQPLSELLSVEPHPSVIFSLAETLLGFVFVSRYFNGDYLADMHVAACHLLLELVSYFQPPVTRKSAPNKTRIVKSPATKMIAFTNFSEVLASLQSRLGRNHLTCSHKLMLLLTDDLHCLLQKFDIFVDRVLCEIIQIMLATKTKSILAASALHKVKFLRACVGKRDQASDNWCKRYVPPLFDAVETSICEQTMRIDAEGTQERWRNPRKSKAAGSGWRNILRDNHNHQTSSTEDMKLNVEYKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNJ4</accession>
    <name>A0A0R3WNJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2319</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000960">
        <property type="protein sequence ID" value="VDM19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WNJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000233201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000233201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000233201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277971at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000233201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34032" checksum="047FCEAC1D77F4C5" modified="2016-01-20" version="1">MTTVAGQQGLSDISGNVEELRKSLPHVDLETGLKNRVVKRDPIAGLGDLPKEHCDFGKPKTSHQNKKSNVNHPVDLLPFFKVLRVAISTGLEGGKDFNKTLLSWDADTAALLPKSSQNSTKGDSKLARNPIALTGNLGEEVDSLRCTSRPRKSSTRGPQRDPISGKGDFGEREWDPIWKYNGRARRARSSTGSLQLIVTRSHECSNCASEILQYSDYSLQSSDWRKCKNIRNHNGGEAKRWFNTKDAAIEKSLFISFNCKSDILARNIITGENCANFDISQEMKPSGPRRRSGTNHYRFCLIDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNR8</accession>
    <name>A0A0R3WNR8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2393</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001031">
        <property type="protein sequence ID" value="VDM19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNR8"/>
    <dbReference type="WBParaSite" id="TTAC_0000240601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000240601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000240601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000240601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14738" checksum="8DB6AC1E94D42F0E" modified="2016-01-20" version="1">MCLVVASNGMNVVKDHLSCALLPLPIPIQLTLLDQSHFCKLHLVLTSPDTYTPNSHSHEPLSPFRLLTDSNPSLVPFLLPYFPSSSLFYHTSLINIHTCTHTLDNLFEEGEDGKEVGKEGGDVHLTIEKVYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP46</accession>
    <name>A0A0R3WP46_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2521</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001169">
        <property type="protein sequence ID" value="VDM20334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP46"/>
    <dbReference type="WBParaSite" id="TTAC_0000253401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000253401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000253401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000253401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11575" checksum="8C29B0722092D476" modified="2016-01-20" version="1">MLVLDDQYAPRNGLLIAGISGDVFDSVSVSLGKNATYLYFVCIDIQHGRWGTNIDVGQGQNQRLANRAFQLFCMLAFTAKMLFRLFLGQFEKLAHDLDETPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP66</accession>
    <name>A0A0R3WP66_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2541</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01001186">
        <property type="protein sequence ID" value="VDM20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP66"/>
    <dbReference type="STRING" id="6205.A0A0R3WP66"/>
    <dbReference type="WBParaSite" id="TTAC_0000255401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000255401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000255401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="331"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000255401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="796" mass="88603" checksum="4538F57E766E6D26" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPB9</accession>
    <name>A0A0R3WPB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2594</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001255">
        <property type="protein sequence ID" value="VDM20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000260901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000260901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000260901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674273at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132960" evidence="2">
        <location>
            <begin position="26"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="58"/>
            <end position="183"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM20595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000260901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34282" checksum="9BB93F47FA1224D2" modified="2016-01-20" version="1">MLSHVSTHCTAFALSVLLLVCEVNAVSSSVLVPLGLLARIVILVAFIAVTWCQPPTDAERAQILEAHLAVRENVYPPATNMMLMEYSYELEHLADYWAALCEFKHPDPKLHPHYRGLGQNIAIMGGMTPTFTEAVCAYRSENKYYNYFNKSCSGMCGHYTQHNVLCTITPPSEWRRWFGRTQTSWDAPCGNAMAFDLTGAIRSISACVNTSLRKWHSLHLLCPSSSPIEGDRLVEGMLAHFCRGNYKGRHPYEYGKSCSKCPEGYMCYRNQCAKGVRCKQVYPLMRIRNEANRKVPKCDIFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPC2</accession>
    <name>A0A0R3WPC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001261">
        <property type="protein sequence ID" value="VDM20604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000261201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000261201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000261201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000261201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15935" checksum="84A19FF374691459" modified="2016-01-20" version="1">MPNQVDSHYPSIHHQSIGTDVSRHCLPHRLHLHAASTFLPSSLPSSLFASLPSITPSRVPLIHLSSPSKSATPHRRMGTCYACISTVVDCAAFESDGFNSTEVLTGEEGRARLSQWHRRRERKLLTHTYHIASRRRISCAIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPV1</accession>
    <name>A0A0R3WPV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2776</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001493">
        <property type="protein sequence ID" value="VDM21127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000279101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000279101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000279101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000279101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17526" checksum="1FE8D2E577A64575" modified="2016-01-20" version="1">MCASDSILAMLPTPTCNELSSKCLGHRDGLQGVAPDSLTMGSRLARRVIDLQVRGCMLHILRNPLLPIIHCTRPTPNHRLKSQRFTVGKSGPDLWQVGNATPTIPMETCEIMLVHIDSKSADVSALREDIANLRVESLRPLLSNKAEGRQSATPAVDGIAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQC7</accession>
    <name>A0A0R3WQC7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2952</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01001725">
        <property type="protein sequence ID" value="VDM21593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQC7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQC7"/>
    <dbReference type="WBParaSite" id="TTAC_0000296701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000296701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000296701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="48"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="194"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000296701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31252" checksum="84433D8B42610D54" modified="2016-01-20" version="1">METILFRNGAYCMNRCLQGYLKTSGVRFATSSTTPTFNKPGNEGLRIGVPKEIYPEEKRVSLTPSAVKTLTDKGFSLVVQAGAGASAQYLDTEYVKAGAKLVETGAKDLYAQSDVVLKVRSPLVDKEVNLLNPNSTLITMVYPAQNKELVNMLAERKITLLALDCIPRISRAQAFDVLSSMANIAGYKAVVEAASHYSKFFAGQITAAGRIPPAKVLVVGGGVAGLSAVATARGLGATVRAFDTREAVREQVESLGAEFLTIQFKASFFMYPSSPTSCSVIDLLRRSGNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU4</accession>
    <name>A0A0R3WQU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3119</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001954">
        <property type="protein sequence ID" value="VDM21994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000313401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132962" evidence="2">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="3">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53442" checksum="33E554AF6EBDB005" modified="2016-01-20" version="1">MLALHLLALLLCFIHVKTLSPEAFPTIDEVELIAHELINPFTPYFRDPKYRGKRICKGFSTWQDALFDNYEKLKAKFARNCSHILGNLIISEIRPNEDIGFLNSVEEVSGYVFIRRVTKPHFGLPKLRIIRGEESVQIRGQAFTLLVTETYTSNRDFMLDIEFPSLEAILMHGVGFFDNPGLCYAPFSVNWDDILEYPDLQPVILVPMNSRSATSHWITACATRYADASRASIHSTTSPSFMNESNATTRLRRNFSENLLTAVALNNTQSPHSTNSMPTVQPPTVSFSTFETNLTEVVLIKAVSGGTQKGDENPEVFLDRQEGGTTVSTTETANRAENLTHTTQDPSGSSSEFGELFTNETFRVLWNLSSETGPQLKWKCHDSCFKRNGRSFCWGPGVNQCQIPTRFYDVLTSAWKVNKEGRVALGHMCVSKCPDGFLLDGDHCVLKCSRPGTQQVRNVCVQCPPTGCPKSGFQLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRL1</accession>
    <name>A0A0R3WRL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3386</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002351">
        <property type="protein sequence ID" value="VDM22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WRL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000340101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000340101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000340101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267848at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000340101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33515" checksum="99F256CE976692A3" modified="2016-01-20" version="1">MAKMFPGFWTTEPNAVHYCLRASLNAVNELRQVILNALLSLEGLIILRIPPSLLPDLVNIMTELGFNTHPRKLLLLAITDTLVFPEEPTKLRNCPGIFPFLADIQSASIYMRRCLRQRFSQFAFQCLEASTIANAAELDTLTEVIEWLPEFWLRCVTASTWNNFNDNLTHTSAFVLSPFRLLACPLTLQASSTWFREVCDSEGIFRRIDESNRDLVRWLVTTWPWPNEKLPLVFAPFERSGVPADSIMTSSASSSASTSMIMYDSSASLPALLSATASGSGAVGSGRHVRRISPCPISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTF3</accession>
    <name>A0A0R3WTF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4026</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003514">
        <property type="protein sequence ID" value="VDM24012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTF3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000404301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000404301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000404301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000404301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11650" checksum="C63FA6BE4123E322" modified="2016-01-20" version="1">MHVDLDREFQLEPIPDQLVKGQRLLLSCQPPKGEPAPKVYWLKNGKRVEAQTFPHIIIDDYNRLIIEQVELQDEGNYTCVADTLGLEQRYSTAEVTVLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTY1</accession>
    <name>A0A0R3WTY1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LSDAT_euk domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003913">
        <property type="protein sequence ID" value="VDM24425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTY1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTY1"/>
    <dbReference type="WBParaSite" id="TTAC_0000422101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000422101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000422101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994106at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF43">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000422101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23542" checksum="9F816BF73EAF902C" modified="2016-01-20" version="1">MTVSRVPTGRQILRVFSSTWQLKPPTLVISVHGSYANLKKRFNFTMKKGLWKTMESVGCWIIGDALDRGIGKIAGEAVAEYVEAYGGDKMLAIGVTPMNSLKFKHLFNTNASIIYYPSEEDETLTDPSMTLVQKYCSKRFHIDKNYNYLVMVSTPSCSGKQKNQHGPSTKSQTRMIVENEHVIETRVAVERMVIGWRTVGVLPLFLSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU31</accession>
    <name>A0A0R3WU31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coronin-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004025">
        <property type="protein sequence ID" value="VDM24543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU31"/>
    <dbReference type="STRING" id="6205.A0A0R3WU31"/>
    <dbReference type="WBParaSite" id="TTAC_0000427101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000427101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000427101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000427101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6116" checksum="47267C20D07F601A" modified="2016-01-20" version="1">MENLKSLLRTEGATLTRFERPLPFPVDPNFLIATVDADSAMLFKVSKKCSCKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUE9</accession>
    <name>A0A0R3WUE9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4374</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004261">
        <property type="protein sequence ID" value="VDM24788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUE9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUE9"/>
    <dbReference type="WBParaSite" id="TTAC_0000438901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000438901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000438901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021984at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="127"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000438901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="577" mass="65283" checksum="55EC1686639A4AD2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUZ2</accession>
    <name>A0A0R3WUZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cupin_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4567</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004782">
        <property type="protein sequence ID" value="VDM25204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000458201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000458201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000458201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052535">
        <property type="entry name" value="Bacilysin_H2HPP_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112:SF1">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000458201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11644" checksum="8F13D2DA3FF461E1" modified="2016-01-20" version="1">MPEFVVHHWNEAEDGVLSRDTMKNKLNKMGYSATPYTFSAGNVFGAHTHDVDKMDVVVDGELEFSMYGKSIILKAGDALEVPKDVPHSAKVRGNKALEFFDATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVK2</accession>
    <name>A0A0R3WVK2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS4778</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01005309">
        <property type="protein sequence ID" value="VDM25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVK2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000479201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000479201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000479201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000479201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27176" checksum="A0C24FFC13167B4A" modified="2016-01-20" version="1">MEKIYHEQQVDRFCAQHCLNGLLQGPYFTVESLAEIAHNLDDKERRARNSSQMDCLNTDESGNFSVQVIAMALQNLGLELVRYMRKSEEAEAARADPTSQRAFICHFDMHWLAIRRLGCQWFDLNSLHARPRLISNTYLSIYLAQLNSEGYSIYFVTGHLPECEADQYLMLYPVSETYLTQPSPSSGGRGSERDADLQKALVLSLADDANDISLQSVLADSKREAEELEMQKALRISMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVX1</accession>
    <name>A0A0R3WVX1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4896</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005620">
        <property type="protein sequence ID" value="VDM25844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000491101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000491101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000491101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000491101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17750" checksum="3F923F375E639D81" modified="2016-01-20" version="1">MLALSVAIATLLCFGLFYLGFIQSHHFRRLLQKTCQPHTVSNPPKERHTALPSAMHNSPLSPYQIPSSRVQQQQGSRLAAPVPFIKEYSDQRATYFEELSKVHDSIAECEEVTTEAQTYRPIPLPRSGKPYLSPKVNIANRISKGGKEEEEEGEEGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW73</accession>
    <name>A0A0R3WW73_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005912">
        <property type="protein sequence ID" value="VDM26034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW73"/>
    <dbReference type="STRING" id="6205.A0A0R3WW73"/>
    <dbReference type="WBParaSite" id="TTAC_0000501301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000501301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000501301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000501301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6809" checksum="4E91C2D75D2E7AB4" modified="2016-01-20" version="1">MVHNVRLEEIIEGICVAMHMLSREPGTRLHLSRFRSRKSGSCIVIADSTAYTVQSHLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWH3</accession>
    <name>A0A0R3WWH3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5099</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01006260">
        <property type="protein sequence ID" value="VDM26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWH3"/>
    <dbReference type="STRING" id="6205.A0A0R3WWH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000511301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000511301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000511301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF184">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TRICORNERED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM26263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000511301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="6348" checksum="BCBF734999883134" modified="2016-01-20" version="1">MRQKDQIAHVRAERDILVKANNPWVVKMFYSFQDSVNLYLVMEFLPGGEFFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX35</accession>
    <name>A0A0R3WX35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">I-set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5310</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006988">
        <property type="protein sequence ID" value="VDM26666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX35"/>
    <dbReference type="STRING" id="6205.A0A0R3WX35"/>
    <dbReference type="WBParaSite" id="TTAC_0000532501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000532501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000532501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6136057at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="3">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000532501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21183" checksum="1E93568E83F4C60C" modified="2016-01-20" version="1">NEEGEGEPSRPTPPVTAENQPAPPRIITPADGVQGGPGSGVGGLQDITIKAGQELRMPVAWFGHPPPTATWLQNGEPVKPGGERNISMTTEPQPRSTEPLVGGALEEEPGGTSVLRVPKASRADSGEWQVVLKNDLGQTTSSCRVVVLGENPFVIFRIMSYNDCQFELSLELGNTELDILPVDHNSGNNFLQIGKPSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX39</accession>
    <name>A0A0R3WX39_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLGL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007003">
        <property type="protein sequence ID" value="VDM26672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX39"/>
    <dbReference type="STRING" id="6205.A0A0R3WX39"/>
    <dbReference type="WBParaSite" id="TTAC_0000532901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000532901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000532901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000532901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7040" checksum="A930E67523428EAD" modified="2016-01-20" version="1">MIIFSGGNRRDSLDAVIDDDEGDHTTPSITIMRGKRLAVMQMDFSIVTFTTLCTSPYFSGMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX59</accession>
    <name>A0A0R3WX59_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5332</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007082">
        <property type="protein sequence ID" value="VDM26722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX59"/>
    <dbReference type="WBParaSite" id="TTAC_0000534901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000534901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000534901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000534901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12626" checksum="7759477965A0F68C" modified="2016-01-20" version="1">MQCTLLTSSSSLQSAIRSGKDSRMSGRGDSRVGPPAGIGGSISAWTDTLVLMASADDESMSVRDTRLNPHFAIETEAAPTSPSSEVSSRECLEASLSDALNKLLSQRRQYLSDDGGEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXB9</accession>
    <name>A0A0R3WXB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fer4_20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5394</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007328">
        <property type="protein sequence ID" value="VDM26880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXB9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000540901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000540901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000540901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000016">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroprymidine dehydrogenase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000540901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13800" checksum="8AD736B20DDF1EF8" modified="2016-01-20" version="1">MLPLHYDFSDAKLTTLGERGALREAARCLKCADAPCQHSCPTQLDVKAFVGSIGKKNYYGAAKAILSDNPNGLTCGMVCPTSDLCVGACNLTATEEGPINIGGLQQFAVEMFANMDVPQVGLFHCFLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG3</accession>
    <name>A0A0R3WXG3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007517">
        <property type="protein sequence ID" value="VDM26997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000545301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF112">
        <property type="entry name" value="48 RELATED 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25108" checksum="34E78E6AE1E8305F" modified="2016-01-20" version="1">MHQNVKIDDFYGFKGLRARIPTLPYEKRLSKVDTLRLAIGYIKFLQDLVTNENYQAKSSEGNCSEGENNKIDQPCEAQQQTQSFIASVQRFAVSAAANSDGSERFNCSHSAPNTASSIHQSARKVILNLSVRMACKITAMNTLDSEATTDDLITRPGQTWRRVHDHYVTKSIVDDAPVREAVLIGHSLSWHQRPNTFEIPRVSPNNKRTLVTKLWTPQPNPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXH4</accession>
    <name>A0A0R3WXH4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5450</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01007571">
        <property type="protein sequence ID" value="VDM27022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXH4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000546401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000546401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000546401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM27022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000546401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19383" checksum="7327A2D9A4A7685C" modified="2016-01-20" version="1">MCRQTIMCLLRYPEAEYKEALKLEQDNQQALKGLKNVKNLKSSGNKRDYYKILGVKRTASDKEISQAYRELAGKNHPDRFPDEEQKKAAEKRFLDINDAREVLLDKKMRAQFDSGIDPKDPEAQARSAFQTGEGFAHGHQFFTSSGPFGFNFHNFDPFGAGGGHFEFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXW9</accession>
    <name>A0A0R3WXW9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5594</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008143">
        <property type="protein sequence ID" value="VDM27295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXW9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000560901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000560901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000560901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000560901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7428" checksum="20EEA85131959F27" modified="2016-01-20" version="1">MMGSEFKAVISQTTMSDSMQQMAAEVSADASVRFNTLVSISKFIKETFEKHYGNIWQCVVGKQFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYN0</accession>
    <name>A0A0R3WYN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009377">
        <property type="protein sequence ID" value="VDM27812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000587001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000587001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000587001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000587001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40617" checksum="10EE8983994C3D4E" modified="2016-01-20" version="1">MEEEKARIADAYERLSRSFVLLNGDGDSMRSFDFPLSISSSARGDLTVPFGGDLSSPFAISAHDYEMALKEIDELRHRVYVLEDDKARKSEECDRLISDLQLLSHKLRDLQSRVPSPSSVPVFPVVDFEKEDSMLSSSSPVLMESIPMNVNLHKSADKESSIVHVDEGLMAENMLRLMTIQSELDLERAKVGKLEERLAIMEAEKKAYLRNYDEVNDELKSRRSEQRSLEAKLQQMTGVKSREAEVAAMEIDALRHRVYDLEDEIARKSEECDRLLNELGLLTHEAKMNTSRKSPTLTVWPHSQGALLDDLREKTDEMESDTAHEGEVAAKELEEMCARLHDMEEEKARNVEECGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYP6</accession>
    <name>A0A0R3WYP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009453">
        <property type="protein sequence ID" value="VDM27848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYP6"/>
    <dbReference type="WBParaSite" id="TTAC_0000588601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000588601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000588601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000588601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18330" checksum="1AACA69083E8CF75" modified="2016-01-20" version="1">MIDSSGCRCLIAFSPTVHLSSLHFVLSHFLPSITPPPPPPPPPPPTTTTTTTTTTNTTATTTTTNTTGPSICAATTTTTPICRRVIPPTSNSPSYTFRRCTDEVDVAMTLYTAEFVLMEVNFDELCHCFRSLNSAFNQFHENASLNLMDAQSPGEEVDVHSIKHSPNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZD5</accession>
    <name>A0A0R3WZD5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Superoxide dismutase</fullName>
            <ecNumber evidence="6 13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS6133</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6 13"/>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZD5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZD5"/>
    <dbReference type="WBParaSite" id="TTAC_0000614801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000614801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000614801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Mn], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM30293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000614801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24506" checksum="5417D3650D34EA0D" modified="2016-01-20" version="1">MLASGLYRRYLGPAYKCTRIFSALKHTLPDLPYDFGALEPVISADIMKCHYQKHHAGYVNNLNIAEEKLAEALDKGDVTKVISLQPALKFNGGGHINHSIFWCNLCPNGGGEPSGPLADAIKRDFGSFEAFKEKMTNAAVSVLGSGWGWLGFESGSGRLRIATCANQDPLEGTTGLKPLLGIDVWEHAYYLQYKNQRPDYVKAIWKIINWKDVAERFAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZF5</accession>
    <name>A0A0R3WZF5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rad21_Rec8_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6159</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZF5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZF5"/>
    <dbReference type="WBParaSite" id="TTAC_0000617401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000617401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000617401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="744"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000617401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="799" mass="86823" checksum="303DE39058C62319" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZN4</accession>
    <name>A0A0R3WZN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6256</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZN4"/>
    <dbReference type="STRING" id="6205.A0A0R3WZN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000627101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000627101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000627101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000627101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39286" checksum="E0EF4D03816E59B6" modified="2016-01-20" version="1">MAEVPGCSLPTSTEDLSPEEVALQNEIASLKAQLEAARKEVADTDFYTMTKEVVELGRLKFKFRKTLRGHIAKVASVRWASDSQLILSAGQDGKLIVWDGHTANKVRMIPLKTAWVLGCAISPSMHQVVSGGLDNLISVFSLSSPEGTPAQLIQELAGHSGYISSLDYIDETKLLSASGDKTLGLWDMEKGELVSTFSGHTNDVNSVRVCRTNKNLAVSVSSDYTCRTWDIRNAKCTQLFEGHEQDVNGVDIFPSGQAFATSSDDTSCRLWDIRSDQAVAAYVDEFIQCGSTCVALSRSGRVLIAGYDDFNCHVWDVLREERVGIMSAHDARVSSLAVNEMGNAIVTGSWDSLCYVWTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1R5</accession>
    <name>A0A0R3X1R5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enkurin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1R5"/>
    <dbReference type="STRING" id="6205.A0A0R3X1R5"/>
    <dbReference type="WBParaSite" id="TTAC_0000717301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000717301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000717301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000717301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40646" checksum="6753F769A176D61B" modified="2016-01-20" version="1">MARNQGAILNLLQWQNQPTSSSVRYNRRFTSGDPHFKSTDCKIGHISYTYLINFSVERNFVRENIQRVRMPKISPIAVTPSSHISDSINAGTGTVDMYLGAVDRDQSSEDMKNYCENGNQFNQQKKPLTSDIGTQTELQNDKTVNCRFHKSPPKRSGFLRAHEKTGQLNAMMSLSEIPVKKLIRTPQLTRISVPRASSAKDVKFTRRNLNYVRANANAVSNGCVVDRRSTNRQSMHPPSAQSRSFGRLPPYLSDLSLVSYNAEYTERERQQPERGLKKEAQRLKVTEECQKKKEKTHCTPLKRVSYAKTLDEITRAPTHIPTTCNKDLRAQQEDRLSDLKEVIRAFRKPVVFITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2E0</accession>
    <name>A0A0R3X2E0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7436</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2E0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2E0"/>
    <dbReference type="WBParaSite" id="TTAC_0000745101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000745101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000745101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000745101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="867" mass="97257" checksum="039788E4ED8C6EB6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2R5</accession>
    <name>A0A0R3X2R5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reticulocalbin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7586</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020386">
        <property type="protein sequence ID" value="VDM31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2R5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2R5"/>
    <dbReference type="WBParaSite" id="TTAC_0000760101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000760101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000760101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6223661at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF98">
        <property type="entry name" value="45 KDA CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000760101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37889" checksum="525E47C21B96E145" modified="2016-01-20" version="1">MWPRLTSILEHLYLTTGNHFHDAMARSRDLLLCFFFAQALSYAEDLSTHPYEAKERLGRLFNMIDASHDGEVDVNELVTWINAVFRQVSNIQITHNIILLPNCALSRADKRAAREMLQRQDTNNDGYVSMAEYMDENFGYTLQEIEAIRKDSSTESRQILESVDDEMERFARADVNGDGQLDVEELVAFNSPHHHGHMAAYVVSEVLRHQDYNGDGRLHLEEYLADSKDVEVLEYEKERFADIDKNGDGYADTDELRLHYLEEAEKYARREAENLMAESDVNSDGRLTQAEVSEAYEAWLDSPATEHGELLQDMKMYQLTQHGGLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X423</accession>
    <name>A0A0R3X423_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8116</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020450">
        <property type="protein sequence ID" value="VDM32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X423"/>
    <dbReference type="STRING" id="6205.A0A0R3X423"/>
    <dbReference type="WBParaSite" id="TTAC_0000813101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000813101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000813101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247992at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000813101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28930" checksum="FC706D5FDA9861A5" modified="2016-01-20" version="1">MFPTSSSCRQLISLSIPSRSKKYYPGWRDPFSLTDYDNLSKGYPSVTDQWESEWSSTKVVPHELKAFDINRLPHHLVARNRRVPLPVKYDHERRLAYQRRLFGVCGLSSGVNPCTLFDSCEFLAKENELRKRLEPDIEEFKRMEAEEKAMKAKVEEEKIRKITENLERLPEIMEKYRANQEKKAQEIRSQEGKRRQLLEEACFFSIVARDRFGYYVDRRDPKFLKMVEEKQEEAKLAKKASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X424</accession>
    <name>A0A0R3X424_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8117</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM32620.1"/>
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        <property type="gene ID" value="TTAC_0000813201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5915976at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic cytokinesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="896"/>
            <end position="1064"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000813201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1099" mass="119327" checksum="B1D0FA62289E0B9B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4G3</accession>
    <name>A0A0R3X4G3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="TTAC_0000830201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="VDM32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000830201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21888" checksum="06A8571A0AB7FCBA" modified="2016-01-20" version="1">MHGLEAKPLHRGRKVESVASCNAPPVSKDLPHQVSQWVAGRPALQAVVATSTTIEVVERLAIGLLWAADLLPSLRHIMAPLLSRLVTSTLLLHCMTAVTVQCHLQQPPPSTRAEKVQTSVMATTEPSFPLKTSLPHQRCIFKLNFYFRFIFYTKTAIQRQLLCDISGRVVMSYSSLAKRRGPALRLTLDSIFCLTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4N9</accession>
    <name>A0A0R3X4N9_HYDTA</name>
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        <submittedName>
            <fullName evidence="12">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8372</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000838701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TFP11"/>
    </dbReference>
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        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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            <begin position="42"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000838701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="844" mass="94336" checksum="C456EE9CAED80CE2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4Q2</accession>
    <name>A0A0R3X4Q2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TCTP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8386</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCTP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X4Q2"/>
    <dbReference type="WBParaSite" id="TTAC_0000840101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000840101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000840101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000840101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18774" checksum="6671A7117DBD0038" modified="2016-01-20" version="1">MLLFSDAFPIKKINDHIWEVEGKMIKVNQGVDDALIGANPSTEEGGEGVDDGVISVINVVYSHNLEELPFSNKKDYTAYLKDYLKLVTKRVAEKSPEKEKEFQATVQSYWKDTVLKKFEDWQFYRPPNYEAEHQYLIPCNYRDDGVTPYFVFICDGLDEEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5J7</accession>
    <name>A0A0R3X5J7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS8730</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020572">
        <property type="protein sequence ID" value="VDM33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5J7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5J7"/>
    <dbReference type="WBParaSite" id="TTAC_0000874501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000874501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000874501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="115"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="491"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDM33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000874501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="743" mass="81291" checksum="EA2FDB5F9E9C0B96" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5R6</accession>
    <name>A0A0R3X5R6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8811</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020593">
        <property type="protein sequence ID" value="VDM33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5R6"/>
    <dbReference type="STRING" id="6205.A0A0R3X5R6"/>
    <dbReference type="WBParaSite" id="TTAC_0000882601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000882601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000882601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2126778at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000068">
        <property type="entry name" value="Islet cell autoantigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="47"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000882601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58379" checksum="617B4E6D4AC4B066" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U0</accession>
    <name>A0A0R3X5U0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cleavage and polyadenylation specificity factor subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8839</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020603">
        <property type="protein sequence ID" value="VDM33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U0"/>
    <dbReference type="STRING" id="6205.A0A0R3X5U0"/>
    <dbReference type="WBParaSite" id="TTAC_0000885401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000885401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000885401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057951">
        <property type="entry name" value="CPSF6/7_RSLD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25524">
        <property type="entry name" value="RSLD_CPSF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="64"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000885401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="55889" checksum="9C9C04ED452A8924" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5X3</accession>
    <name>A0A0R3X5X3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">14_3_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8874</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020615">
        <property type="protein sequence ID" value="VDM33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5X3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5X3"/>
    <dbReference type="WBParaSite" id="TTAC_0000888901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000888901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000888901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000888901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29404" checksum="41819F2F14F6CFF2" modified="2016-01-20" version="1">MSELLSTEWLKDLPLKDRDSYVNTAKCLEQAERFDDMAVCMKEVTKFDKELNNEERNLLSVAFKNVVGSRRNSYRVLSSRLSRTQDPEKQSLTKEYLDILQKELNAICSDVLQLIEERLYPSCSNAEGKVFYKKMMGDYYRYKAENAKGEDHKQVVEASLKAYEEATEIANEKLSCTHPIRLGLALNYSVFYYEIMNSPDRACQLAKKAFDDAVSDVDSANDDSYKDSTLIMQLLRDNLALWTSDPEETENTEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X647</accession>
    <name>A0A0R3X647_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8951</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020634">
        <property type="protein sequence ID" value="VDM33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X647"/>
    <dbReference type="STRING" id="6205.A0A0R3X647"/>
    <dbReference type="WBParaSite" id="TTAC_0000896601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000896601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30106" checksum="0C43EC9A099C41EE" modified="2016-01-20" version="1">MPQNEHIELHRKRHGFRLDYFERRRKKEAREPHLRAQKARKLRGLKAKIANRERFKEKVQMRKTIRLHEMRNVKQKAGETGVIGERPVFLLDREEQNMSKVLSNSVKQKRAEKAGKWQVPLPKVRMVSDAEAFRVVKSGKSKRKAWKRMVTKMCYVGENFTRKPPKYERFIRPMALRATRANVTHPDLKSTFCLPIIGVKKNPSSPLYTSLGVITKGTIIEASVNVSDLGLVTPGGKVVWGKYAQVTNNPENEGCVNAVLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X713</accession>
    <name>A0A0R3X713_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9309</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020756">
        <property type="protein sequence ID" value="VDM34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X713"/>
    <dbReference type="STRING" id="6205.A0A0R3X713"/>
    <dbReference type="WBParaSite" id="TTAC_0000932401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41897" checksum="C484BDA5EE0775A4" modified="2016-01-20" version="1">MYGEEAVPVVIDNGSGVSKSGFAGEDSPRSVIPSVIGRPKYESVITAMAEKDAYVGDEAQTKRGMLFLKHPIEHGYVNDWEDMEKLWNQIFFNELRVNPEEHPVLLTDPPLNPKANRERMATIMFETFNVPAMYIALQAVLALHASGRMTGLVLDSGDGATHTIPVYEGYAITSAIDRLDLAGREVTEYLMRLLRGRGTAFRSTSEREVVREIKERLGYVARDFEEELIRAETTGEVEKNYELPDGHVITIGSERFQCAEALMRPSLIGKECPGLAESVFQSIGRSDMNTRKDLYYNVVLSGGSTMFPGMADRLKKDISEMAPSSVSVRIVAQPERKYCVWIGGSILGSLSSFRKVWISKEDYEEVGPGIVHKKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7N8</accession>
    <name>A0A0R3X7N8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9548</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020884">
        <property type="protein sequence ID" value="VDM34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7N8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7N8"/>
    <dbReference type="WBParaSite" id="TTAC_0000956301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000956301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000956301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000956301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10866" checksum="5407840FED88C45F" modified="2016-01-20" version="1">MIVLVSSQCILHDIHAREEHVKEDQNGLRSLHITLPIDEIYEENHLHIRCGGGRLVVEGEKDDSYFSRSFPVPSDVDPESLNAKLYDGILTISGPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8F9</accession>
    <name>A0A0R3X8F9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9819</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021078">
        <property type="protein sequence ID" value="VDM34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8F9"/>
    <dbReference type="STRING" id="6205.A0A0R3X8F9"/>
    <dbReference type="WBParaSite" id="TTAC_0000983401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000983401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000983401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5913487at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000983401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9431" checksum="D14B17430A130507" modified="2016-01-20" version="1">MVPRQILRLCRPTPITLLLRLASTPSSLCLVPIGQAQPLRESLYEPGQLILHRHFGCRGVILQSWSARLFDKNIALVTDQPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8R3</accession>
    <name>A0A0R3X8R3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9923</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021164">
        <property type="protein sequence ID" value="VDM34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8R3"/>
    <dbReference type="STRING" id="6205.A0A0R3X8R3"/>
    <dbReference type="WBParaSite" id="TTAC_0000993801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000993801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000993801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6319925at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000993801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32584" checksum="36D6B95E6ED8AAB1" modified="2016-01-20" version="1">MNDGEGEQPNKKANGGERKDKKKHEDFLEVISKVAKQIYEQIAEFFEKWMSNLTEEQQFKDKSSRTESEDKGGLSVCGRIIKIPGCKGKEGSSEGRKEPPGEEDEKMKKLGVKGDEEPGEGGDKNAGEKENKKLNGGGEEETGEKQAGNGEGGVSEGKNDEQQDDEEKGDEQQGDEGEEEGEEEKEGEGEQGDEEGGEEEEEEDGDEGEEEEEDEEEIEGEEEQGDEEEEEEEEEEEEEDGDEGEEEGEEEQGDEDDEDEGEQGDEEEDEEEEEEEEEGEAQREDEEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9I7</accession>
    <name>A0A0R3X9I7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10197</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021418">
        <property type="protein sequence ID" value="VDM35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9I7"/>
    <dbReference type="STRING" id="6205.A0A0R3X9I7"/>
    <dbReference type="WBParaSite" id="TTAC_0001021201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001021201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001021201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RIM zinc finger" evidence="3">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001021201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="50555" checksum="A3F64B31326E2FF8" modified="2016-01-20" version="1">MSLRLSSQTTLTPPVCQVVHRGSKVFQRLPILTDASPSSSSTSTTNTASASNAQLANSIGGPIARAKDEFFGGVTRRGLGTERPLPSVHHNRTSGDLFGAVSNFFTRTGGCSGNYGDVCEICHLTKFTGNAGHNCVQCDRKTCVRCGGWFGAQSSWMCKNCFSNLSSSSAVTHGVRDPKTSTPSGFVPRGRESSSSPLTTTEPSLNPLLMPKIGSPSTPATTTASTSSISASNVATVDRSLSSYAGVASRTRLREALKDNRSVSEEERVWSHYQPTPSSHTYLLRSHQSPQNYYQHPPVPPHSHSHQQQNPQRQQSYSSIPPRYLQQHSSHYPAAVTQHPYNAPQYRHSTGPPVERSYRRTFGEAVWTHSVVPPPVRLERHAFRSTEIGGVEGGGVSTTSCGSAEDSPHGGFHAGYLRRGGGGQTDPGSVSEPCQSEAYSRGSKTDAMVLWQVNLLKFHLQESKDISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9M0</accession>
    <name>A0A0R3X9M0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase_H2C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10230</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021450">
        <property type="protein sequence ID" value="VDM35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9M0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9M0"/>
    <dbReference type="WBParaSite" id="TTAC_0001024501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001024501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001024501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012272at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001024501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37346" checksum="82FD79A33FDB22E1" modified="2016-01-20" version="1">MFILDQCLVLPVNGSGLNFNDGERIVWPAGRAFELGVSVEPTQMGVLMKGHQTASQYASLLHGFRYWPPIEIEKRANDRALASGLVLERNFQLICSYNDAGLNTDPFTVQILLSSPVIAQEMQAGNNVVYHDNSHDNLDDSVPVGEEYIDDDYDDGEDNYEDDDVMSVDDPTGARAAQWPSVARSYKRPDSSLQYRSPLDGADFAHSDKEVRSGDSLALHQKDISLESNASGVNNLGLAIGLSLGCFAILTIIVAFFISKSTGFRRGQLSFFRSGERKSFGRPQFHPETRLNVIENPIEKLEVRILIPVIDLPSMRVKQFYGSSLSFSLSTMSPDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9N1</accession>
    <name>A0A0R3X9N1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amyloid protein-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10241</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021464">
        <property type="protein sequence ID" value="VDM35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9N1"/>
    <dbReference type="STRING" id="6205.A0A0R3X9N1"/>
    <dbReference type="WBParaSite" id="TTAC_0001025601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001025601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001025601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001025601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24869" checksum="06C158121D4DBDAB" modified="2016-01-20" version="1">MVPTRTFLSLTNSLASVDGELCSVVLPSLNGVYEIDRSGYQVVAHHLCRHILLQEAMSWLSTLGGGFSCLGEKFEDAAEIAGEISLRQMYLAISMKIPVFQARCRLFFAQSLMQRGRLKAAELIIRDVYSFSKSASLYDNPPEVHLDLMCRGIWKRLSHLWSIRRSSRHRTQRLQLHLQTNEIGILPFSEQPLSTMCDFTDTYNRRLFPDITAVLKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9N3</accession>
    <name>A0A0R3X9N3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10243</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021465">
        <property type="protein sequence ID" value="VDM35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001025801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001025801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001025801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001025801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16427" checksum="2DD26488DBCFCBBB" modified="2016-01-20" version="1">MPFFLSSFSLSLSPFFFFSFFVSFLFVSKWXXXXMERDSEAEGDVREGVEVGGIGEEGNGDAVRWEEEEEEEEEEEKDIGSDMVLEAASQSGREEEAEEKRWDWRVLRVFVTMERCCIELMCLEWVRQSESTESSLLSEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA38</accession>
    <name>A0A0R3XA38_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10398</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021653">
        <property type="protein sequence ID" value="VDM35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA38"/>
    <dbReference type="WBParaSite" id="TTAC_0001041501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001041501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001041501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001041501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34594" checksum="6E9731DD8B4A84C0" modified="2016-01-20" version="1">MPNCSFLEYSHLHTFTRGYDFVHIPLSLAICVCGVLANAINVVVLNQPGMQSSTNLLVAALSIGEGTVMAIYIFYVTMYRIDRKLELGMSKPYAYTLFILVYAQNLFHAFSSWMIVFLSAFRLAFMRAGVAALHTCSYSRAKMGILTNAVISLILSAPFLFAHHVVKDCTRSVNGTDAFKLDFVSNYSLTTLLLVTTGVFMKVLPIVLSTIFTALLIRTLLKSQRRRNRLKNEKTETEQRIPPTQLEHSNSSAKATSSKRLSIKRSNDHDSNSRNIYQTTNIMIALTALYIITYLPQVRFFKGGKTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAG6</accession>
    <name>A0A0R3XAG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10526</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021802">
        <property type="protein sequence ID" value="VDM35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAG6"/>
    <dbReference type="WBParaSite" id="TTAC_0001054301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001054301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001054301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001054301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6764" checksum="4D2E27D9E5BDC261" modified="2016-01-20" version="1">EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEKEEGEGRGRTSALLLSCIKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAT9</accession>
    <name>A0A0R3XAT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10649</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021988">
        <property type="protein sequence ID" value="VDM35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAT9"/>
    <dbReference type="STRING" id="6205.A0A0R3XAT9"/>
    <dbReference type="WBParaSite" id="TTAC_0001066601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001066601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001066601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001066601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18484" checksum="FAAE7617032E00E2" modified="2016-01-20" version="1">SPFLNIDPSLLVNDPSDQFIFPEGNRHRGRFERSFSEIGSMVIGGCAFGGTRALYSAWNDPELAKLPTKALQRTQILNHVTKSSASWAQTAGSIGLIYAIADFAIHKLRGGADDEINMVSSAMATGLIYRSPGFFAPGGWQRCLRGGVFGLAIGFAGAAFTSWDRIKELLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB63</accession>
    <name>A0A0R3XB63_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10772</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022223">
        <property type="protein sequence ID" value="VDM35752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB63"/>
    <dbReference type="STRING" id="6205.A0A0R3XB63"/>
    <dbReference type="WBParaSite" id="TTAC_0001079001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001079001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001079001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0041">Annexin</keyword>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001079001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33268" checksum="07954800B0E3A4C5" modified="2016-01-20" version="1">MLIEILGTRTSQQRVEIAEAYKGSYGEDLKERLQGELSGDFGELVDLMFYTIPELKAQLCYDAIKGAGTDELALIEVICTSTNSEIEELKKEYAKAAENTLEEDVVGDTSGYFKRILVALLAAQRHEPTEQQLKDIASRGLDSIIDKKAAEADAQKLYDAGEKRLGTDEETFITILCTRSPWQLIGISKAYEKISKLRLVEAIASETKGYFRQALLTTLLANTNAPMAFAEHFNNGLSGLGTNDDQIMRLIVWRSEVDMKEIKNCYLIRYNRDLVDDIRGDTSGDYEKLLVRLLGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB64</accession>
    <name>A0A0R3XB64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10774</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022225">
        <property type="protein sequence ID" value="VDM35754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB64"/>
    <dbReference type="STRING" id="6205.A0A0R3XB64"/>
    <dbReference type="WBParaSite" id="TTAC_0001079101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001079101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001079101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001079101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22479" checksum="765F0D08915F384E" modified="2016-01-20" version="1">MEVEGDSGDFAILRKDLGRCKALLGLVSADSEPGILRCGLSVLLLRSIAPNHFLFDSVNAFPRLAFPCLSSTDLRRLLQNHTALINEASTAVKKAWFKKLLQAEAEKREALRKTHESDVMEKIEPNTHFSPVPFPSREVAVQEALMSTRPIVGGKPEAHSRSKRGVERNCETTTLKEVEPTKLATKLNSTDSVFLEQLAEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBB5</accession>
    <name>A0A0R3XBB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TNRC6-PABC_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10825</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022313">
        <property type="protein sequence ID" value="VDM35805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBB5"/>
    <dbReference type="STRING" id="6205.A0A0R3XBB5"/>
    <dbReference type="WBParaSite" id="TTAC_0001084201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001084201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001084201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001084201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19875" checksum="D74E93FB88008309" modified="2016-01-20" version="1">MCCLQTGLPGSCFRGDVSGGNGSGSGSGSIDPTLMDYNSWTSSTQQQQQPHTGPAHPSSNLQPVNDHFSRRIIGNVGVGGTNDESHFANAWNAATPNDRANQWSRNSMPLWSSSSVVRADQSDSPNGARLGGVMGMSTNPESSVELANCVRAGKVVHLGLNKVEYWLNVLTNFTYESTDSLDNGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBK5</accession>
    <name>A0A0R3XBK5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="1">Arginyltransferase 1</shortName>
            <shortName evidence="1">R-transferase 1</shortName>
            <ecNumber evidence="1">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10915</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01022518">
        <property type="protein sequence ID" value="VDM35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBK5"/>
    <dbReference type="WBParaSite" id="TTAC_0001093201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001093201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001093201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001093201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42958" checksum="9DB8625F6FA93C8E" modified="2016-01-20" version="1">MKAQKKVLRALHSYLKTGKTSKEEEKPHAKAEYCRDPPVMTKDLASNKHERSLETSGDSGFSEAKDDPVGTRRTGSARRRRWQALQAKMARRAEELGVSYDVIFEVRMYSCSPKSPELEATLDQEFELFSTYQVAVHHDAPEKWTRDSFIAYLVDSPLVSTHDAEAEANGAPQFGTYHQQYWLDGKKLIGVGVIDIVPGCLSSVYFFYDPAFAFLRLGTYSALQEVAFVRHLHRTYGSVVPAYADFTFYHMGFYVHSCGKMVYKNNYLPSYLACPETYEWIPIERCQRLLDRNSYARFAEPTVAKMPSVDVDKVVLLLPLSTSLAWILPKPQFTVEGNTIVTTVGAARRILSEHDFQLVRDWANLVPSIGTIRINFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBS2</accession>
    <name>A0A0R3XBS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10982</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022661">
        <property type="protein sequence ID" value="VDM35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBS2"/>
    <dbReference type="STRING" id="6205.A0A0R3XBS2"/>
    <dbReference type="WBParaSite" id="TTAC_0001099901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001099901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001099901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001099901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13176" checksum="BA10B49A71B2A874" modified="2016-01-20" version="1">MAELGRCGHAEPFAIKNVVSRLVTSGSGGGSGSALHQQQQQFPAYPCLQQSCMVPGNRFSEVFPSSLLPPPPPLQRIDADTVVVGAEVAGAGSLGRRKAAPPAPPLRTTTLKADEVCEKATAPLQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBT8</accession>
    <name>A0A0R3XBT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10998</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022702">
        <property type="protein sequence ID" value="VDM35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBT8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBT8"/>
    <dbReference type="WBParaSite" id="TTAC_0001101501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001101501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001101501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970722at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001101501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="34480" checksum="BE6AA5329187C59B" modified="2016-01-20" version="1">MAQNEESIKSQTKSPNSHLPCVTCPDNSISSFDLLNSYRSAAIFLKAAADSQNPRKSMTLPTVSPLPTSTIKQRCPSPPDGDSASSAAAAAASLISRPPCQHSPTTSSKIQAAFVMAMAASSPPSTCPSSSSSGHQGEHGANDFRSDTQSSLGALFRPPPSTAYETVDSGGNGAGDVGFPPPGSGALPSFVPFTNSSGASPDISASTCLTNAMLLPASIVNVLGQQMQSNQYHQPQSPAYLSTINTNSGGGFPQQPQQQQGGPQGGSGAGGTSSEAQGPSSLFRSVAGAIPPPQPPPVPSVAGTTDNSRYSAPGRSVSTTLHEDTNNKREQRLLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC56</accession>
    <name>A0A0R3XC56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain roadblock-type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11116</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022993">
        <property type="protein sequence ID" value="VDM36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC56"/>
    <dbReference type="STRING" id="6205.A0A0R3XC56"/>
    <dbReference type="WBParaSite" id="TTAC_0001113301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001113301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001113301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001113301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19131" checksum="771F9F87090E8B8B" modified="2016-01-20" version="1">MHDVVWNSMIFQLQDFQEYMQKNPIENSLLFSLIGLSSQSQTTRGISSVGHGEEECHRARALTMPARERLGPSFNVLTSMPVVTTSGRGEVTFCELQRASQVFLRYQTEVAVQAVRRTAQAMQSLASRLALSPANAWHECAAFGTAVKRVLKNRHGIQASGDLRLEVLRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD34</accession>
    <name>A0A0R3XD34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dynein light chain tctex-type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11444</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024216">
        <property type="protein sequence ID" value="VDM36525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD34"/>
    <dbReference type="STRING" id="6205.A0A0R3XD34"/>
    <dbReference type="WBParaSite" id="TTAC_0001146101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001146101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001146101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM36525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001146101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13030" checksum="A13A8D1670B13441" modified="2016-01-20" version="1">MDNEATEETTFVVDEVTNIVKEVCGYVSIENNIGSSSYVHTKVPQWTSTIVEQILNQLTKLGKPFKYIVTCVIMQKCGAGLHTASSCYWDNSTDGSCTVKWENKSMYFIVTVFGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDM1</accession>
    <name>A0A158RDM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000138">
        <property type="protein sequence ID" value="VDM17216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000094601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000094601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000094601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10602932at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000094601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="27911" checksum="2D1684FB18E760E5" modified="2016-06-08" version="1">MPHSTTSTTALPLSSARSADDAPHGLVSAAFLPGECHVCVRILARACASKSVNRSIGPLPPLPTAFLRLLQLSLTRSRVAWMDARLTTTDAWCLECTLIHHEHSSIARTNNGESYTREAASIPAAAVSSSSPIPTATPHSPRAQRIPGMNALPHVYVRMCVGRFTYDHRSHRHASAFSLPLEGAGTSLSLSLILWLPIHDRYRASSSYVSSSSSCASSACSVARAAVLAFELEARAANADRQGVYLCVVYVVYRRRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDU6</accession>
    <name>A0A158RDU6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amiloride sensitive cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6085</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDU6"/>
    <dbReference type="WBParaSite" id="TTAC_0000610001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000610001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000610001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250341at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000610001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="733" mass="81910" checksum="62684A7E41B8D7AF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE04</accession>
    <name>A0A158RE04_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHHA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6400</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase class C family. Prune subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE04"/>
    <dbReference type="STRING" id="6205.A0A158RE04"/>
    <dbReference type="WBParaSite" id="TTAC_0000641501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="6">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="7">
        <location>
            <begin position="234"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47755" checksum="264E733ED8958A9A" modified="2016-06-08" version="1">MLSAFLKYLHSLPKSCPTFKFVIVTGNESCDLDSIACATCYAYIKSKEDPDKEVIYIPYCNIPESDIDLRTEATFWLRNCQIDKKDLFYAGSLNWLLGPEYAKELSLILVDHFQKEPSNAFVFCPVSEIIDHHPLLPDYRKPGTCQFFLVEKVGSCSSLLVHELFNRISPALIPPELCRLLYGAILIDTDGLSERAVEIQKATQKDVEAVRKLETFAGMALHTVGTTRTSIYAAILEAKFCIDGLSLWDLLRRDCKKVIADSDSHTDIVCSTITGMDFKELLDRDDFNQEAARFCEEQNARVLVCVTVGLASLPSRDHCLDQPSSMPLSKKFHRGVVVTAPVRYRNLMNSVKDAIFILSFNIMLWAHLLANAKDFLVGYPLGGELSHHSSVGEVETGVYVARITDEAVTRKQLIPLLIDFLRSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE64</accession>
    <name>A0A158RE64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Potassium voltage-gated channel subfamily H member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS6687</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020315">
        <property type="protein sequence ID" value="VDM30934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE64"/>
    <dbReference type="STRING" id="6205.A0A158RE64"/>
    <dbReference type="WBParaSite" id="TTAC_0000670201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000670201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000670201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086013">
        <property type="term" value="P:membrane repolarization during cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000020">
        <property type="entry name" value="Potassium channel, voltage-gated eag-related subfamily H, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF506">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="390"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM30934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000670201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="834" mass="94035" checksum="7F735272C7CADB53" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE84</accession>
    <name>A0A158RE84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6826</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020325">
        <property type="protein sequence ID" value="VDM31098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE84"/>
    <dbReference type="STRING" id="6205.A0A158RE84"/>
    <dbReference type="WBParaSite" id="TTAC_0000684101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000684101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000684101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000053">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="396"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000684101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="913" mass="103457" checksum="49DC3651B310079E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REI1</accession>
    <name>A0A158REI1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7325</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020362">
        <property type="protein sequence ID" value="VDM31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REI1"/>
    <dbReference type="STRING" id="6205.A0A158REI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000734001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000734001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000734001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000734001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="48721" checksum="7915428E9A64493C" modified="2016-06-08" version="1">MHRFTFFSKLLRQGTFTASSKEEGLASHKLLLHGGILSVSSPGTFVLSPIALRVVDKLTAFIDYKMSEVGGQKCLFPTLGRSQLWAQSGRWEKFGADMFRLNDRTHEEEACEFVHSFDLGSSVLPLRIYQISAKFRDEIKPKLGLLRCREFLMKDMYSFDVDAEAAKETYDTLSNTYLEIFHTLRLPIFKVTAEGGLMGDCPSHEFHCLLPVGEDTLSVCPSCKKAVLAANSGIATSGVLQDSRVCPDCGLSCQVSKVLQMGCYGIGITRLLATALEYFTTTSTEGNPPTELRWPSGFAPYSGAIALQKDNAKDALSTDELNVVLARFRDFPSPSTSLTPGSTFFAGLLPRGDILVDDRPRLSLGRKLLDLRRLGVPWILVAKSLQSSPSPEYELVDVNRGGISFAASLDDAATAFTCSDFEVPLLSVSDGQRKKLWHGSGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E7S7</accession>
    <name>A0A3P7E7S7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000527">
        <property type="protein sequence ID" value="VDM18551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E7S7"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="82"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="4">
        <location>
            <begin position="344"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="79495" checksum="DC0780721CDA670D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EM41</accession>
    <name>A0A3P7EM41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003668">
        <property type="protein sequence ID" value="VDM24180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EM41"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="138" mass="15611" checksum="D757CF43708506F8" modified="2019-02-13" version="1">MSKRGLQAVLITGILAIVLLTVVAVVAVVVKKRKEKIVRQDQYMKMCNDDEDAIEADFKSILPKKFGMRLRKAPPPIHLPDFVQTVATYATNDYAVLREEFKTLQCMAATQQGEKCLTMEVGAHPENHLRNRYQNVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ESH3</accession>
    <name>A0A3P7ESH3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002626">
        <property type="protein sequence ID" value="VDM22856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ESH3"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072383">
        <property type="term" value="P:plus-end-directed vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901098">
        <property type="term" value="P:positive regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753:SF2">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69979">
        <property type="entry name" value="Eea1 homodimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="72"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="312" mass="35141" checksum="02DA35682BB2A126" modified="2019-02-13" version="1">MIFELQTEIDSLKANLDDSAKTLKYLREENKVLLEKTANLLLETQVKEEQVVGLETTVKAIRSSERTLRSSLDGAKETIKKKDAAIESLQQELQQCMSDKEAKYNECDCLTKQINALTSESNSVNATNAKLNAELSEMRSRLTCLVDSEKTLKQKMVELNATLASQNEELRNHANIVIELESRLNSTLAEQQALMDQLIENQKKSKQMETALQTSHHEMEGLQRIVLDLGRQNQALQITQDRLTNRQWISDDSVQSCSNCQKDFSISVRKHHCRHCGKVFCQACSSKKTATSASKDPLRVCDGCFAELTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EUQ1</accession>
    <name>A0A3P7EUQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007601">
        <property type="protein sequence ID" value="VDM27031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EUQ1"/>
    <dbReference type="OrthoDB" id="6271928at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="144" mass="16331" checksum="419BF4548023E28C" modified="2019-02-13" version="1">MRLRMIKIICDELALSHFAMGFVLYFSTGKNFRDGVHRLFIRCGICGRDKTTDTTRNSMSSEVGRSSVSTRLTREKKILITTLANHQQEGKLLALRRGLHYFKRGRKNSDFPGLDQCGRRGERQPSKLPLTSKNNANGDFPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EWB3</accession>
    <name>A0A3P7EWB3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005293">
        <property type="protein sequence ID" value="VDM25613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EWB3"/>
    <dbReference type="OrthoDB" id="6268850at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9013" checksum="4C72E42A7F94F5F4" modified="2019-02-13" version="1">MSPSVAKAKGESAFHRRKAYDEARRKSSIFISHVDPRRRPSITASAVVGRQRTDAASLRVSKRAEARRQVMDKNRDGLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXV1</accession>
    <name>A0A3P7EXV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001630">
        <property type="protein sequence ID" value="VDM21424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXV1"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="158" mass="16497" checksum="B078FC5A71F93616" modified="2019-02-13" version="1">MADAPSFVHRLVLNITENLPCPASMIAENHASGMLWNAASTIASGLMTVVTLGYSRRTANAKVEAKAESSSPGGGVLHPLAKQSCHLLLVLTTQSTGFISATSGVSTANGEDGTTPALNSVDTSAVTASRSIFRDIGSNPYREALFALTPLKVRFYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EY10</accession>
    <name>A0A3P7EY10_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat domain phosphoinositide-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001668">
        <property type="protein sequence ID" value="VDM21494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EY10"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="41708" checksum="2C893B0FAAC6A189" modified="2019-02-13" version="1">MHLQNVTSIAAHDGVLAALAFNTSSTLLATASERGTVVRVFSIPDGDKLMEFRRGLARYATICSLNFSTDNRFLVCASNTETVHVFKLYGSASPQSSAKVEDSACTPASSQLTTDTNLASTTDDTTSASSWTGSLVNWVGGALKAGVAYLPNPVAEVFSQDRSFAFAWIPSGAANLANATPSAAGQANATAPITPHGDGEYGGSGQAGTAFKKTAALLSYGDQYRLLVAGLDGYLHIFTFDPARGGEATLLRTQRWVLVPGDAKKDGNYRVINFRNVKYMSDEFIAIRKAIRKRANNFNSALMLSDLLTSGPGPSNIPSQQQKQSQGPTDTSSSSRRSFAAVASSSGDSSAAQELLATEVMMLVTPSTAPQGHCYEAEFPTIQSSHPTPSRKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZP0</accession>
    <name>A0A3P7EZP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007316">
        <property type="protein sequence ID" value="VDM26873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZP0"/>
    <dbReference type="OrthoDB" id="70519at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="75" mass="8401" checksum="12BD71EEDDAFB338" modified="2019-02-13" version="1">MHAAARGKALSVFHWLQKQYPRLVLIRDNMGRTATDLSSQRTVFSSALKLPLVGRYAAMIRINPYSNDLQSLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F750</accession>
    <name>A0A3P7F750_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020359">
        <property type="protein sequence ID" value="VDM31641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F750"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="228"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="439" mass="47853" checksum="80574CC0CAF92D14" modified="2019-02-13" version="1">MSMLYMLVYIPMIVPATWLLNHYGLRVSILIGATLNVLGAWIKCLSMELSQPVPSPASNASFPLLMVAQLVCALGQVFLLGVPAQLAATWFSKTELAMATAIGVFGNQVGCALGFGLPPLMVPAVTNSTGVADFEDFRRGFRIMLYGGAAIMSIDLIFVAIFFKEEPAIAPSLAQYKRILQRRAQMTGDNQDEADFDSAFEPESSVLTLEESELVNQSYFHQVVHCFKSVSFILLNICYGVNTGVYYEIGTLLNSIVAEFFPTEQVAIGWIGFSMVIAGLVGSIVAGAVLKKTGLYRRVLIVFYFLSVASMGAFMGSIYSNLIGTVFLTMILLGFFQSGFLPLGFEYAAEITYPIDEGLTSGILNTSAHIFGIILTQVATAMIGKYGSLPTNIFILVCMVIAAVPACKLSSCIFSANMTHNKFFLLHSFHQLRLFIHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCP6</accession>
    <name>A0A3P7FCP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006873">
        <property type="protein sequence ID" value="VDM26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCP6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="162" mass="17463" checksum="A06FA7C6E0F05CFB" modified="2019-02-13" version="1">MCLVLRNYSRCSRFYPYALHSSSSYSSSAGAGAAAASIAFHSLHAICHLRNQPTHNSTFSTSAVARFARTCGITEPPIDAHRPRCLGPTYVPTLHGSMIRLIFLYVPLPAMMWLGVYVQSPTPSHHSYACNSSGCAGCRFRRHIVTIKATSNVEGGEDGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FXT7</accession>
    <name>A0A3P7FXT7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020646">
        <property type="protein sequence ID" value="VDM33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FXT7"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="308"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="682" mass="76023" checksum="5C1C59C060234FD9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GF15</accession>
    <name>A0A3P7GF15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001139">
        <property type="protein sequence ID" value="VDM20205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GF15"/>
    <dbReference type="OrthoDB" id="6415470at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="351" mass="39982" checksum="1BB3F72CD9C04C62" modified="2019-02-13" version="1">MRAMAARLGFNFNLDLVRGLRVLSTKSVMFKCDTKHNALWGDAYNELSIGREAYDAIEHLSDTLVNDTSRSVAASLTKKHQRARENIKAGILYRKNFRGPPELSILTSRAREQIAHLSATSPSEWDAVSVSENFPISYRGAGLLLLKQRRNPRRFFRSLDAVVEYDTRSIKNWLTLIEVICTAQVGNHVKASESQIMQVLSSRLPDGLRWIGVENVLNKLAFADGNPALPHPPQTSVEAVNFVKSQHQAGYFQRIAESFYKPIETSSESVSLREQQVSVINKLIPLFKHMDFSVFTQPLMEDTSLTFRTVCRNWLCIDPEPLQLDRSRSPRTRSKVDCDFTKVFRYKRICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GPQ6</accession>
    <name>A0A3P7GPQ6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003331">
        <property type="protein sequence ID" value="VDM23815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GPQ6"/>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="195" mass="22659" checksum="89B328A40783B13A" modified="2019-02-13" version="1">MSHLHANRVIHRDIKGQNVLLTDNADVKLVDFGVSAQLDRTIGKRNTFIGTPYWMAPEVINCEQDASCTYDARSDIWSLGITALEMAEGRPPLCEMHPMRALFLIMRNQPPRLKTGLGARQWSPRFHDFIFKSLAKDFRKRPTTTELLKHDFVANLPNERQVRIHLKDYIDRHKRTRRSTFILDFVSIPLISTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GXH8</accession>
    <name>A0A3P7GXH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007009">
        <property type="protein sequence ID" value="VDM26675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GXH8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="91" mass="9824" checksum="B0BE61C863E56DE1" modified="2019-02-13" version="1">MDKDQTSNGHCDESSSKTSPSTAVFNECPQKHQLEGEDERSSAPIKVSDDHSLPPTSPVSPCVSRRVDVTKTPAAPQPYWIANPASKFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H7W5</accession>
    <name>A0A3P7H7W5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H7W5"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="47549" checksum="EA2FD7ADCE98BC49" modified="2019-02-13" version="1">MHQTSQAPLLLTSAADCGKQEAILAWDPIAGNQVASFSGFAAASGTLTTSNGIVFSAVCRKPIIQSWSLQSSASFKRLTTKGVVNALAFSHDGFFMFLAIEKSIYVYQVCSGCLIAVLEASHMAPIGSLVVSQRQAGLPLPLLLSADTSGLVACWLALVSSGESFAIGSRDSTNISNEPESDNKHKPLCVLEESRPIRCLCVLPQDDRFIFAGTDNGVLHSIWLRDPKKPSACEVAFRRCFVDVELPSTEKAICHACASPVDSGLSLLAVSTLSGLVEILRQDACLVRLQSFSVVPPLSGNSGSPRITGLLMVTRPSWLLESQTALSSSAKPDASGSLESLRPAKRHLGWHVEDLLYLQLPNLKRDRISDDYLGDIYQDEFFLTTPSRSFALPIDTVRKCTASTSNTSAEVSTLRREKEALERRNGELMRILVANCLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HMC5</accession>
    <name>A0A3P7HMC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022423">
        <property type="protein sequence ID" value="VDM35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HMC5"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="91" mass="10625" checksum="140FBD6D9A6DFED8" modified="2019-02-13" version="1">MTSSDTSGSERSWQFWLKVFVVLVGMFSVGVFAYVQARYCCDICQRWCRLNRVCVVREPSKERIAKMRMEQRLPTSRFCVVNEVDTFAAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HT60</accession>
    <name>A0A3P7HT60_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01026278">
        <property type="protein sequence ID" value="VDM37632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HT60"/>
    <dbReference type="OrthoDB" id="6111134at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM37632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="143" mass="15682" checksum="184A9A74EAC45308" modified="2019-02-13" version="1">MFASQSKIYAEMGVEALDHALEGYNVCVFAYGQTGSGKSYTMMGKPDDPVHMGLSPQGYNVCVFAYGQTGSGKSYTMMGKPDDPVHMGLSPRLCRDLFTRLEKIQKLRGQEFQSIVESFVRKVFGGAIVILTGIREVAFTSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHU4</accession>
    <name>A0A0R3WHU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AA_TRNA_LIGASE_II domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS133</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000009">
        <property type="protein sequence ID" value="VDM15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHU4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000013201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000013201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000013201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="140"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000013201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56427" checksum="EBB59257E9BAD60F" modified="2016-01-20" version="1">MKFNLFSTLYNASLRTHTCGELRESDIGKAVTLCGWLYNTRVSSSFLLIKDAYGITQIVQLRLGLPTCDSVIRVHGIVQSRPPKNINKSMQTGMIEVRASKIETLNRASECIPFKMKERTRLGLRYRYLQLRQSEFQKRLRFRSEFLRKLRNYLCEDKGFVDVETPCLFKRTPGGAQEFIVPSQFQGQFYSLPQSPQQFKQLLMIGGIDRYMQVARCFRDEISRPDRQPEFTQLDIEASFISKEDVYGFVESALAYAWPEVCKFNEVTGELKTPFPRMSYEEAMKRYGSDKPDIRFDMELKNSRCGANEEFAFFVVPAGYYPDVPIYKPGIFFLWVENFPLFSINELGNFISEHHPFTAPVESEVDLLKTKPASVSDCIKTSGHYDLVCNGQEVGGGSLRIHQADMQRYVLENILGENVAPLKHLLEALASGAPPHGGFALGVDRLTAILTNAQTIRDVIAFPKTSEGRDLLSGSPDVVPNTDLDRYFIRVLRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI36</accession>
    <name>A0A0R3WI36_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS235</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI36"/>
    <dbReference type="STRING" id="6205.A0A0R3WI36"/>
    <dbReference type="WBParaSite" id="TTAC_0000023401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043073561" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="72637" checksum="5F6E9BF1AD77756A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIH2</accession>
    <name>A0A0R3WIH2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-CAP/cofactor C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS398</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000033">
        <property type="protein sequence ID" value="VDM16385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIH2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIH2"/>
    <dbReference type="WBParaSite" id="TTAC_0000039701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000039701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000039701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427777at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="272"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000039701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="699" mass="77473" checksum="E6D230ACEA21CFE6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJR5</accession>
    <name>A0A0R3WJR5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS929</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000132">
        <property type="protein sequence ID" value="VDM17190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJR5"/>
    <dbReference type="STRING" id="6205.A0A0R3WJR5"/>
    <dbReference type="WBParaSite" id="TTAC_0000092801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000092801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000092801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="459"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000092801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69329" checksum="522EF5D15130534D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKL6</accession>
    <name>A0A0R3WKL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1261</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000238">
        <property type="protein sequence ID" value="VDM17711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKL6"/>
    <dbReference type="STRING" id="6205.A0A0R3WKL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000126001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000126001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000126001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="1">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000126001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33194" checksum="3B3862AA2C1DA63D" modified="2016-01-20" version="1">MISTANWVLSRLVPQISALLFNLLFDLARTSYALRDQLARTNGLVVFAQALWQSSPSHLTESLLNGLLEAARYLTSELLAASPYSSAGGVPVLLVLFRQLFNKLLFANGLWLRAPVKVQDRLYGFLADEFRVDLLGQSGKSIVASALHAIKYYFWMVRPAQPLLDSIPGQRTYIAERPPLKYLARIRSNLLLLIKPLILQQYQISPYDSNFVSNGEEVDNLLNFLCTVGEPDNLKDVLYFAVVLMSQHPAVMVPCFDRHDGIQCVFQLLTLNDEDSRLYALKLFGFFLKYSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLF4</accession>
    <name>A0A0R3WLF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1579</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000386">
        <property type="protein sequence ID" value="VDM18242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLF4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000159201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000159201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000159201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000159201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34712" checksum="EDEF44587511C178" modified="2016-01-20" version="1">MRCITTLAGGFAEAFIYKLVIESQSDYPLGRPFPPRLESLDIRNINLRRFDNRILRLTNLSALSIEASRISSVPKDVECLRLTLLCLKSNLIETWPSVSKGSALAISLRYLNLSGNRIAWLPDDFWNLENLESLLITDNHLAALPAANLQRLKKLRDLHLQNNRLRCLPYALSQFRRMGMLSLSGNPWVKPFPPVERNEAPKSLFHFASAVVLRNYGHLLHALVLQLPRNVEMQLSVLRRCFRCGRVCGAEADWYVGYIELDYTERIYSPLLGVRSEVKPVCIRYYCSPHCGIRGRMYEHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK4</accession>
    <name>A0A0R3WLK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted RxLR effector peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1629</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000415">
        <property type="protein sequence ID" value="VDM18310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000164201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132892" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10288" checksum="C4473FEB97875CF9" modified="2016-01-20" version="1">MIRFALRFSILLGISSGVDTYPRLDDLDARKEAVVDRRMLINTWKGTLLHTVEVDIHDLANLDDNAQTYFFSYRRGNASNPVKMQMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLY0</accession>
    <name>A0A0R3WLY0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1755</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000490">
        <property type="protein sequence ID" value="VDM18495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLY0"/>
    <dbReference type="STRING" id="6205.A0A0R3WLY0"/>
    <dbReference type="WBParaSite" id="TTAC_0000176801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000176801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000176801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="801"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1005"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM18495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000176801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1240" mass="136940" checksum="10E608C37607488D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMP5</accession>
    <name>A0A0R3WMP5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000688">
        <property type="protein sequence ID" value="VDM18760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMP5"/>
    <dbReference type="STRING" id="6205.A0A0R3WMP5"/>
    <dbReference type="WBParaSite" id="TTAC_0000203301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000203301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000203301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000203301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="44885" checksum="A07F459DD1D5C23D" modified="2016-01-20" version="1">MPYGRPVSRRRRRRFQGTDQASVIPVVKREAKETTQHASTGSETSASPHEAPRHCNRQGAISSATTIPVAVPSPDLLRAGHKAGVWPLRERLLLASALLDTDNQQLTWPPISRRLAKFTPPPSCGFVRPPTWCSARACAKQYSLLLDSAEMFRKQQVDVERSAEEGRVVFQAPSDVAAATATVGLSLAEFIVKRLTVERVEELRSQIISARQKYRLFKEMLEKVESGKFDSCIDTIWDIVQRQQEEHFASGSSELPADTPPEVVEFVRDLNSWTDPFDVPSSVWMVAGGSGAALRSVPSIAKVTTPKKMPPVTSKPKSPPERRPSDSSRNSTAEAAEGEGGDASCDRTSTPSTSVMSESDLEYGEDTLKAESPDSGGLDEKEEEEESTIPLLSSSGGSPKPKLKATSSPDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMQ6</accession>
    <name>A0A0R3WMQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 221 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2031</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000698">
        <property type="protein sequence ID" value="VDM18771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000204401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000204401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000204401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196393at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000204401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27062" checksum="7962AC902F416097" modified="2016-01-20" version="1">MNKDFAKKTKALFDSEVVAVKEAISTGIYVSYRPTGTKYERQDCLRVSSAGRCFCSHLLKDHNKFSATSRNTACTQPGCSCRRFLFAPGRPEDFGEFWLPKRRDFNREAYRMKCKCKHTHEEHVPYPSPFRCSARPCNCLAFSSASICAACDQRWEQHDTIFETEEERKNAGRQIREDWYPFSELPAMRDIALTGEGNPQVERLTDALPIQPLSQPTSSTSRPTNETNNTPFRPSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN75</accession>
    <name>A0A0R3WN75_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protocadherin-11 X-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2200</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000845">
        <property type="protein sequence ID" value="VDM19212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN75"/>
    <dbReference type="STRING" id="6205.A0A0R3WN75"/>
    <dbReference type="WBParaSite" id="TTAC_0000221301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000221301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000221301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="108"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="176"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="296"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="412"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="516"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="622"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="946"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000221301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118834" checksum="2D6AE0E74CDE9970" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN90</accession>
    <name>A0A0R3WN90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Centrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2215</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000857">
        <property type="protein sequence ID" value="VDM19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN90"/>
    <dbReference type="STRING" id="6205.A0A0R3WN90"/>
    <dbReference type="WBParaSite" id="TTAC_0000222801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000222801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000222801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000222801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19632" checksum="FC619886B9BA492D" modified="2016-01-20" version="1">MSTNTKKSSNSSLLKKKSDGNFRANAMETQEIQEAFELFDVDKTGYIDTKDLKVAMRALGFEPKKEEIKKLIAEYDPEGRGVLSFSDFLRMMSLKMQDKDAREEVLKAFKLFDDDETGAISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEAEFLRIMKKTNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPI0</accession>
    <name>A0A0R3WPI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2655</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001337">
        <property type="protein sequence ID" value="VDM20785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000267001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000267001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000267001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000267001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39847" checksum="F91052B7D8455AB5" modified="2016-01-20" version="1">MNRDMQPNNFGQPGLLGNGTFPLGRPPLIPRAGFIPNPNMNPPRIPHGVIPYNNFVLTAVPRASLPPRIRTSQSKSREARFKPRQIISAKEFAFFAMSLVKSPIACSALQFLQLRKVDAETAILKAVNEELCTHDLLGIYSESPFYRPVLLLRDVQFATPTSTVGQLPDPDNMIRQLKDLAEQKVASVSLMGMMAGTKPTAASLGFCTDYLMHTFNVELDLNLIAFLNEQAKQGNSAGDRYRVILRFGWATQGLCVPTNSQGSSNIRLLATECLPRCLQLRVARRQVPLPEPIFHAGQAVKLGHRLRYSVDITDKVNVIVACLLLVYWLIYLSFSARKAEVQPEFPHCFIPSHLVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN2</accession>
    <name>A0A0R3WPN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myoferlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2707</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001411">
        <property type="protein sequence ID" value="VDM20949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000272201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ferlin A-domain" evidence="8">
        <location>
            <begin position="187"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ferlin B-domain" evidence="9">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="423"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM20949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56331" checksum="17602899EBA15FBA" modified="2016-01-20" version="1">MPHHGFLPTFGPSFINLYGSPREFSDGPDKFEALNLAKGEGCAYRGRVLCEVQTELLDEMQQSGVTPMSEDMKVHVNKYMRRRKYVLHAAFFHANMISIDDAPIEFEVSIGNYGNNLDETVPPCASTTPPTNAVFDGCYYNFLPWGDTKPCTVVECQWEDISFRLYAVNMITRIADNLEYGLENIEVSMKVDLAEEDLASTVIATLDQFIMDCQTPLPEWTEGCTPVNNLDQKLMKLRHDDLEQLKAQAVKLREEATSAEDVVKELKVYLETLRKIFVEPQNSMPDVVIWMIASEKRIAYFRIPAYDLLFSENQMYRGRYCGEVRTIMLKVRKDLTSLLHTLHCSLATSLTLMCTSIQYENEAQIVGKWSSRRPPLTRPNYTDCTGHLETPKENFIPPLGWKWEGDWYISPEFSLMFKKDTGATSFMEDVFYNEKRTPISGWEKASLAYTDAQGYEKPSPDETELPSGWVWEDDAWKVDFNRPCDEEGNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN5</accession>
    <name>A0A0R3WPN5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2710</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01001414">
        <property type="protein sequence ID" value="VDM20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000272501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF349">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE BRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50997" checksum="9945B79D1E83CFA4" modified="2016-01-20" version="1">MLRTSRIITKIFCCINIGLIIVFVWNSLERVDNFNRTTFPCSKPIPCRWPPVVLDDIRTNTSTYNFTICLKLKANTSRNNSLITYPIESLFRNTGTGKMVSFREISDYSRPIWRLAIYPNVWRTYPQDVPIHDIIKAVKSGSPVSAMPEYNFPINILNTSRSVCAGRIKHDLVIIVKSGIFGWEKRDLFRAFIEGQRDLNPNIKIGVVFSIGLPRQHGGRLFNRNGYTTILRGPVGDMMDAYAGRGNEVMQKIAEEIRKYDDIILADYEDTYYNLTWKTVTNLRWLSAFCDKLQNDMFMIIDDDHRVNVSMLMRFLATVPRHIKRTSLLGRIARNDGAFRSPLSKLYLAFQEIPWDIMCPYPRGFCQLIGADIVDDMAIGSAYTRYNYIHEDVYLGLLAFKLGIPLHNVYTMFDHREYERRWPPNASFMVVESRYWDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPW9</accession>
    <name>A0A0R3WPW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001514">
        <property type="protein sequence ID" value="VDM21177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPW9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000280901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000280901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000280901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000280901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10462" checksum="D23EE61086DFE835" modified="2016-01-20" version="1">MPWETRLEKAREMISTSLPDANYAVLKYLMCLLTEVCAHSTQNHMTDVNLGIVFGPNLLWSRYATISSFTEVGQITSFAQLLIANYDDIFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQC0</accession>
    <name>A0A0R3WQC0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001713">
        <property type="protein sequence ID" value="VDM21570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQC0"/>
    <dbReference type="STRING" id="6205.A0A0R3WQC0"/>
    <dbReference type="WBParaSite" id="TTAC_0000296001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000296001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000296001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000296001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40664" checksum="C12A199E09A21C70" modified="2016-01-20" version="1">MHIALNEFLSGRRTALGCILSVSEVSNGWMNVRVDQRLSMVARLFAQTAEAVTRLFRNEGQIATLLEQMLKWCPRETAWFSGENLFEYLPENIAYYHLTQAPAQAHQLKSPTSGQSKEKNFDTQSSGIYAQPLSIEDMKDPFKEWWKSTVSFSQQQLSTVLSSHLADITDLVDTRHTLLSILSTSSLENNVGSAPHPLGHCADLWIDLFRTPFVNHLESLLNSTLNGIFTDFESDLLSLARSLDQMDDKSSQISSDEVMTPFDAEQMSPDLDLASFVWSQSFDSIGLSNLCRKDQVQSLSSLNDSVDQLDISPKDLVMAYFACLVGRRDLLPNSSTTPKATNQLPGPLRWRLSRLLESTAAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU9</accession>
    <name>A0A0R3WQU9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 13 member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3124</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001957">
        <property type="protein sequence ID" value="VDM22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQU9"/>
    <dbReference type="WBParaSite" id="TTAC_0000313901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="121"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33958" checksum="2E6AB2261B0334C4" modified="2016-01-20" version="1">MEHEDEVDAEGSAFGNRGAAQTATDVSPPSGRNCNQAMPSQELVTPQPLNYLCTVCALRLVTVRRMGLLTLERLPLCLVLLIYYFRYFFVFLYPLALLPVVLINTNNITKSAYILLWMSGYWITGVVPLYATALLPMFAGPLMGLQTSGTLSREYLPTSNFLFIASMFLAGAAEHCNLHRRVVIFCLKCMGGDPRLILLGIMIPTWFLSLWMSNSATTLLMVTITETLLNRIDEVTKSIEGSVEEDDSTTKREFKEDGSEKLSPNRSKWQKFGVGLSLSVCYSASCGGMGTLTGTPTNIVVYNLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR98</accession>
    <name>A0A0R3WR98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XRN_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3273</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002165">
        <property type="protein sequence ID" value="VDM22291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR98"/>
    <dbReference type="STRING" id="6205.A0A0R3WR98"/>
    <dbReference type="WBParaSite" id="TTAC_0000328801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000328801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000328801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000328801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11844" checksum="DF3677E26CED3127" modified="2016-01-20" version="1">MGVPKFYRWISQRYPCINQILQPNETIPIDHLYLDLNGIIHTSSHCDDGNPNIYDEDSVFQTIATYLKHIICLIRPQKTIFLAVDGVAPRAKMTQQRARRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSE9</accession>
    <name>A0A0R3WSE9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002846">
        <property type="protein sequence ID" value="VDM23129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSE9"/>
    <dbReference type="STRING" id="6205.A0A0R3WSE9"/>
    <dbReference type="WBParaSite" id="TTAC_0000368901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000368901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000368901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000368901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="24985" checksum="78274F3694F5DB5C" modified="2016-01-20" version="1">MRMASSDCTFETESLIPVGFPSETAGIPISSGSTLQRGQHFLLHQSPVLGCPMSRGPTVEMIAVSCGQDEQRSDSGRGASDEEAMFQGPFPPILCGISVTATEKVSCPVTLAADHRDFISTVAHVETSETPVTTTSGIYLCASSLAGQTGTISTASGAEERPQRSVSTFVTANEKENGSLPLSEVPSALVGNVNKTFSLPREGLCMTQSLLDDHTADESANRLCQEIDHLLFDNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSH3</accession>
    <name>A0A0R3WSH3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 15 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3698</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002888">
        <property type="protein sequence ID" value="VDM23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSH3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000371301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000371301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000371301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="8">
        <location>
            <begin position="380"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000371301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="49879" checksum="77F13D6194D1C54C" modified="2016-01-20" version="1">MKPKDMTKVFGIFLSDVLHADFLCDGLKAASLGKDGFVKVWDVALGELHSSFRVGQGHEPPSCMAVGKVNVNLFSVGDFNGVISVYDMRQPEPTHKFTVPSTPSALHLACDDSIVVSAADHYVYTWESFTGKPFLQENLDVSDIFTHPGGYMHYKLITGLSVVQCPDVHRDPLLLSIGMDRLLRISSLKSFEVFHQERLVSPCTAIATFPNLKYVIVGTESGLVRTFAFTTPSQLLEQERVKINSGNAEIDEPFAVVDPGLKAMVSRFSSKWRGVNFEEGDKALTTEEWFKQSGAVGTRIAPKDWGHKGSKAPLIHEHTIISRVSNASGGGESVRESADMGRVTKMLLRFQHSRALNEALQVCSRARIISKRSPEAAESVTKAPLAVLAVVRELSRRGTLPAAVGGQTEKELARLLRFILQNIWRPWATPTCLNLFRILLSKSVSSFLLNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSQ1</accession>
    <name>A0A0R3WSQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3776</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003030">
        <property type="protein sequence ID" value="VDM23340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000379101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000379101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000379101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132987" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000379101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11965" checksum="285CEEF37823EA20" modified="2016-01-20" version="1">MFAAWSFVYSIWHIAINAALYDDGLLLGRFASLSPHAVVPLFRGSVKGTCSFVGGASSVSTARCGQGMCPVSTVNDLRRHLVMDAISGRAIEEEKEEAEEGAANECTLASIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSZ1</accession>
    <name>A0A0R3WSZ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3865</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003185">
        <property type="protein sequence ID" value="VDM23614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSZ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSZ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000388101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000388101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000388101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000388101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25297" checksum="E5E78E47316179CC" modified="2016-01-20" version="1">MSIIFTFPFQTSIVFTLLPKHFKTDSAVFDFRRLTSLLYEADVVQIVYHVYDGCGRFKGAGSYQSISNPKYRFKLTKGSHQLIATILYADTKKVSYSAKDSDALDKLAHYPLLVRWPLVASNAASISNTANPTSAEGSTTCQLVLEVSTSLATLALADVDYERTCARFVQNGGGARGGEIDGANKAGGDDQNVDLKSPKRDPIFGNLQKFPTVPGHLAAGECVTEVFGVVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSZ5</accession>
    <name>A0A0R3WSZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SKA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003197">
        <property type="protein sequence ID" value="VDM23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000388501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000388501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000388501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274795at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000388501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13831" checksum="686165C3C72F37B8" modified="2016-01-20" version="1">MALPSESMESREASFDEIENLRAEVKRLSDVVAEQSELITHIQGVLIAKLCFPFQKSSEDKPVDKLELLTEFNQHKIAMACLERDNVAMESMIKQLENNGSVRYYFIGIVGCHSCAENQGLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT66</accession>
    <name>A0A0R3WT66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3943</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003332">
        <property type="protein sequence ID" value="VDM23817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT66"/>
    <dbReference type="STRING" id="6205.A0A0R3WT66"/>
    <dbReference type="WBParaSite" id="TTAC_0000395601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000395601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000395601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133067" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000395601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7263" checksum="317443389DC44E6A" modified="2016-01-20" version="1">MNELGVQVKGFHVRSVLLFHFLWHLSLQTESNGTVLSTNWDEVGKGKVEMKPPDGMEYKEYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTN2</accession>
    <name>A0A0R3WTN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vps16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4108</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003680">
        <property type="protein sequence ID" value="VDM24193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WTN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000412201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000412201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000412201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000412201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32326" checksum="D940E899DD429054" modified="2016-01-20" version="1">MLPVHHPILRKPGDLDFLPQYLDALNARNPRAALPHVHRLVKLYASYSREQLLPFLRSTYHYPLNEALALCQSLNYVPETVYLLTRVGRRKDALRLLMEKGAEDAFLLGSKTLTVEQRQAEVASRAIAYCLEEDYSQRRIYLTSYDPPHRLQSKTHPKQSRVSSDGDDFVSVGDNSDGGSADDDDDYGVEAGGGVRRGFSPSHSTSRETGELWKQVVFFAVDKPGFICALLNQASTERIDPTLLLRRIEPNTEIPHLKESLVNLLHNTQVMLGLPYHSFRGIANGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU82</accession>
    <name>A0A0R3WU82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4307</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004118">
        <property type="protein sequence ID" value="VDM24648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU82"/>
    <dbReference type="STRING" id="6205.A0A0R3WU82"/>
    <dbReference type="WBParaSite" id="TTAC_0000432201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000432201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000432201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000432201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12933" checksum="6AE7AA7F8080870C" modified="2016-01-20" version="1">MAANSNSVHNCTEPFGVVFMLGGPGSGKGTICPPIASHFNMIHLSAGELLRKELNTPNSKFSAVIESHMKGGTIVPVAITCSLLHKVSFALSILLEVMPFKVLLTLHYITFTLQYAIFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUE6</accession>
    <name>A0A0R3WUE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4372</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004250">
        <property type="protein sequence ID" value="VDM24783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUE6"/>
    <dbReference type="WBParaSite" id="TTAC_0000438601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000438601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000438601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000438601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="24309" checksum="D20307866C1225CB" modified="2016-01-20" version="1">MAEDEEDEEEEEEQTDEKEMAKDEEDEEEEEEEEEEQTNEKEMAEDEEDEEEEEEQTDEKEMAEDEEDQEEEEEEEEEQTDEKEMAEDEEDEEEEEEEEQTDEKEMAKDEEDEEEEEEEEKEEEEEEEEEATTLSPLPPLLPVLHVSFRKMLKMLPETKSTNLDPLQEETRLSRTIVLSLCPSIQITLIYLNITNLCKHRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUI3</accession>
    <name>A0A0R3WUI3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004341">
        <property type="protein sequence ID" value="VDM24868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUI3"/>
    <dbReference type="STRING" id="6205.A0A0R3WUI3"/>
    <dbReference type="WBParaSite" id="TTAC_0000442301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000442301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000442301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21780">
        <property type="entry name" value="MobB_Trc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000442301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16501" checksum="06AD8E8EAB4B9CC9" modified="2016-01-20" version="1">MTSSESGSIIKDDGCSGSTSFLSLGSSSTSVSSQLPPSHPGREIAISSRTLDSVKIAKVTLENFYNNLATQSQDRQNRYKILECMMESEGLTEDQKQQKRSQHALKESEYLRLKRARLTVDDFTPLKVIGKGAFGEVSSFLFHPRIHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUX5</accession>
    <name>A0A0R3WUX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4550</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004733">
        <property type="protein sequence ID" value="VDM25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUX5"/>
    <dbReference type="STRING" id="6205.A0A0R3WUX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000456501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000456501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000456501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000456501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36776" checksum="068A3D575A786964" modified="2016-01-20" version="1">MSKVFGVDVEELASVFENKGTEEIQITPVRPKDSEEVDEEFEKKKRKEEHLESSKDSKLSSVLESTLSKAPRIKIYKIAALSTCTHEVAYPPGIPFKKLEVFSEPKILTFPFTLDPFQSQAMLCIDNNQSVMVSAHTSAGKTVIAEYAIAKALRDKQRVIYTTPIKALSNQKYREFSEEFPEVGLLTGDATININAGVLIMTTEILQSMLYRGSSIMREVGWVVFDEIHYMRDPERGVVWEESLVLLPDCVRFVFLSATTPNARQFAEWIAFLHAQPCHVVTTDTRPVPLRHYMYPIGGDGLYLVLNEVAGIQVDFRLPIRLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVL7</accession>
    <name>A0A0R3WVL7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4793</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005339">
        <property type="protein sequence ID" value="VDM25654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVL7"/>
    <dbReference type="STRING" id="6205.A0A0R3WVL7"/>
    <dbReference type="WBParaSite" id="TTAC_0000480701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000480701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000480701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000480701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30966" checksum="F2DB64B1B301CAEB" modified="2016-01-20" version="1">MTSCDIITNTSDGIRFFNFNSTDGLKLIAKESENAARAICYTPDGSVLGISDGERISIRNGDDNIEFASIDHTNVSKLVISPDAKYICTFEPFRKTPEYPEGRPNLHVFEVASGKVIDCRVHTLEGTWRPQWSLDSKLCVRVWQGEIQFYVNNNLGEKPAKRLTLKGMRHCSLSKSVRNRNIAVYTPGEKSAPATVYIYAWRNGDCVAVANKSFFRADTVSFHWSDIGTSLLVLASTKVRFYHFHYLHRNEHGGHEVSFGLLLCCGMFVCGTKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWH7</accession>
    <name>A0A0R3WWH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">I-EGF_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS5103</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006272">
        <property type="protein sequence ID" value="VDM26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWH7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWH7"/>
    <dbReference type="WBParaSite" id="TTAC_0000511701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000511701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000511701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0401">Integrin</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Integrin beta epidermal growth factor-like" evidence="11">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta epidermal growth factor-like" evidence="12">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000511701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24027" checksum="7E4DFD5D3ACE4652" modified="2016-01-20" version="1">MVEIQAKCQGETEFTKKTVCKEHPVGGKIEYRVSVTPTRCFSGKKEVILKMVALEEQAVLEVTSACDCPSCDSPAISYQASPRCQYHGHLVCGACVCDPQYSGEFCECSAETSQQEEIMLRQCTRPGDSVPCSDRGRCVCGRCKCNLARYMGLFCECDRHGCKRAFDDNQVCGGPQRGECQCDGTCKCKPGYTGERCDCIDSNANCYDPNNPDVCSCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWJ4</accession>
    <name>A0A0R3WWJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5119</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006306">
        <property type="protein sequence ID" value="VDM26307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000513401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000513401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000513401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259903at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000513401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25388" checksum="66A600456098FB1D" modified="2016-01-20" version="1">MAGTSSSKTPGDSSPFVTVDTIDGTRLQIKRYCLGQKIVNWVLYIKSRLLYLGVEDPVKEVINALSEDALKVALEGGLDINADLDSIFDKLIEIFRFEGRTLTIWSLFSKRLDASVSGKDLVADIKSMTAKIFNRRDKENLIQETALDAFLNALEPRLARIMLQARPHNIDRALELLPRAKRLLASQTKSHAPSPPKLYLSSKVYEYTRKDASSQHVLLLCKATALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWV3</accession>
    <name>A0A0R3WWV3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006673">
        <property type="protein sequence ID" value="VDM26525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000524301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000524301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000524301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000524301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13264" checksum="847B20A68D732CED" modified="2016-01-20" version="1">MHDSAATCASSLTDYCVSRFPFLSPLIGPCGCADQSNWPPSWTGNKPLLTRLLLISCTQSHGGVFENEPDSLLDIARSEEREDAAHLVVTTSAAERKNAFLKKAAEESKVKRLDPKVGLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX25</accession>
    <name>A0A0R3WX25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5298</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006938">
        <property type="protein sequence ID" value="VDM26648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX25"/>
    <dbReference type="STRING" id="6205.A0A0R3WX25"/>
    <dbReference type="WBParaSite" id="TTAC_0000531501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000531501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000531501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419432at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 N-terminal" evidence="1">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000531501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34963" checksum="F73903598FFE28CA" modified="2016-01-20" version="1">MRVNVLQKGFNIHSQPKNYMNFRTNVEEIIYHAVRSDTAKSPYTSFKIANKYISAINDFDVLAGMRVSEAFGGVVMSLLQSLKALVKMVFDSSVRASTVIHRVGDLFLMDEFDIDSFILTSSSYGHWPWLKAFMRRHEIYLNGAEFTRHALTMRELYIKFLYHTVGPKNSLVGEMTQRMLKSGVDGDGGRGVGVGGDSGESAPSLCNAIVSSSPPELAACSGASSASADGQESQFHRSADDFLRLAKWKVDDLSFLVGSDLAIFGTKCHPCISLRLSPLHKPINVLTGIDIWLENILNEVPEVAMCFHNEGIVMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXB2</accession>
    <name>A0A0R3WXB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5387</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007293">
        <property type="protein sequence ID" value="VDM26860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000540201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000540201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000540201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000540201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="4590" checksum="7791228821A88D28" modified="2016-01-20" version="1">MANGGVASVGGSLSVEHKDKVEPHADIILHPFVVNDSVILLQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYM0</accession>
    <name>A0A0R3WYM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5843</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009333">
        <property type="protein sequence ID" value="VDM27791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000586001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000586001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000586001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000586001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29007" checksum="56C4B0F55BCDC871" modified="2016-01-20" version="1">MLKRAKETGVPYEAIMKEYQVRRQKRLEKNKPKDLEDYLGSEPGEGEGAHFLDIRLLKCSPRSDELEATLDEEFRLYSAYQVAVHKDAPEDLKRDDFIGYLVDTLIVGGNDADAEACGAPQVGTYHQQYWLDGKKLIAVGVLDLVPGGLSSVYFFYDTGYNFLRLGIYSALREIAFVRDLHRTFGSRVAAYAEAMQYTLGSYVHSCAKMRYKTQFSPSYLVCPETYTMVPVERCQRMLDGGRCTRFAEADVENAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ01</accession>
    <name>A0A0R3WZ01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5977</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010048">
        <property type="protein sequence ID" value="VDM28107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ01"/>
    <dbReference type="WBParaSite" id="TTAC_0000599101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000599101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000599101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276417at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000599101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13109" checksum="6A8DC88DCD9E9B37" modified="2016-01-20" version="1">MKFIVVYPLHLAENQCFKLVEPTLSIYARANEFRQERHISLEQCRESCVETPSCQGLAFFKRSRRHSTGLCRLFRGSTDADVNDDPDNSAQLINCGENCRLEQNECNLGKQLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ12</accession>
    <name>A0A0R3WZ12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5986</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010077">
        <property type="protein sequence ID" value="VDM28119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ12"/>
    <dbReference type="WBParaSite" id="TTAC_0000600201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000600201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000600201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000600201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11196" checksum="008FA6183743CBFB" modified="2016-01-20" version="1">MRSFVMHLSVLLSPEEVANPFTYGHAILALPGMRYLSFHAALRADLTCTGIACMRYVSRPIQMSLEGLFSPNMALDDTNNFERDLRDIDNFFCSLYGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ65</accession>
    <name>A0A0R3WZ65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010389">
        <property type="protein sequence ID" value="VDM28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ65"/>
    <dbReference type="WBParaSite" id="TTAC_0000605501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000605501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000605501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000605501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9801" checksum="02B096E0A7F787E1" modified="2016-01-20" version="1">MTSWTLELAVKSVREDQLTERRKYIGDNSVTHFYGCIDNFTQYRLLCSFVLSDPPRRLAMMKKTMVSPSEGCEAAQFPYICGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZM4</accession>
    <name>A0A0R3WZM4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6244</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZM4"/>
    <dbReference type="WBParaSite" id="TTAC_0000625901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000625901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000625901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250612at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133114" evidence="3">
        <location>
            <begin position="21"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000625901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="657" mass="74565" checksum="C6FD1FC39C24E783" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X005</accession>
    <name>A0A0R3X005_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6404</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X005"/>
    <dbReference type="WBParaSite" id="TTAC_0000641901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6221880at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29514" checksum="EB8428D8711D9953" modified="2016-01-20" version="1">MLTSSQAIPSSEYFQTGGSSSMQMLESRETAEQVLLSSLRKLDKGKRSRTGLELKRGLLIAFTLFKARQILWQYPTPLPPPQIPPVQLPLASHAPQEEIYLASEDYSPLSGDPSMLSTLEGVGKDFNSDIWQPSNNETATVDVDEEEGEEEDDSDSDDIDIDEEDPFDDFGSHEPIFPPPFPLIFPEEHISASSPSVVHTSSGLTNLTTVVPGSEAHRNFDQNHPAASTHLSNPLVAPFSSSRKRSSTDSDSSENPHVSPLKRLTPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0A3</accession>
    <name>A0A0R3X0A3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6528</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0A3"/>
    <dbReference type="WBParaSite" id="TTAC_0000654301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000654301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000654301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256885at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000654301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17810" checksum="4DF346264F6CA911" modified="2016-01-20" version="1">MVLILNHFRNNIRLLQRLPVSKKQCQDFGAILSSELVRLNHVVFLSLLEHDPFPGNRIPASGVSDTAAIFNAVISGIMRQTLGGKSLSRDVEFFSRCLQLLEAGYVIGMDEIAAQDLAKIERAIDQLEGTNERSRLTSGKKNGVVAIIRDDSSAKSVTFINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0J1</accession>
    <name>A0A0R3X0J1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6636</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0J1"/>
    <dbReference type="STRING" id="6205.A0A0R3X0J1"/>
    <dbReference type="WBParaSite" id="TTAC_0000665101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000665101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000665101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000665101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52466" checksum="162B918444BC1B4A" modified="2016-01-20" version="1">MSSGCVLGHLRLYECKQLFEGTVKKSNHPICTFLCGALLSEHLIICCNHHLPGTRASTSPAGAWLIAPVPTILSVHNGIVALNLISASFGAFILLSFLYNPGISTVMHLSFWFICAYITHLNLNLNTLLTLLFISLLSFELLSSYVGSLTIWEAILLAQICFAFHTNTVFFIIPLLCIYTVERLKMGPSCVTFGTLSISVIWLWSLLSDFASRLVEEKTYPDSVSVFHFEPLHFVKGLITPLNILLVTTVWAPLCIAAILVVIFLSQEGSEGGKTPLALRKIFHFQAGIVYATGLLISPKLLSVAAACVLLVFFLVDWTRRSGPSATSKFLNDVLGPFRDSRDSGELIFTPFALLLGLSLPVWNFCYSWSRDYPMSPQAWSGVITIALGDSVAALVGRRWGHLWFRWPGTHRTLIGSCASFMSQMLLWVGLAAYYGWSWWTGVLPLAFGVLAEAYTEQIDNLAIPLLVMSLFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X104</accession>
    <name>A0A0R3X104_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS_1_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6833</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X104"/>
    <dbReference type="WBParaSite" id="TTAC_0000684801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000684801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000684801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265519at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000684801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="940" mass="103264" checksum="0AF8496F539018E8" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1K4</accession>
    <name>A0A0R3X1K4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7082</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020344">
        <property type="protein sequence ID" value="VDM31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1K4"/>
    <dbReference type="STRING" id="6205.A0A0R3X1K4"/>
    <dbReference type="WBParaSite" id="TTAC_0000709701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000709701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000709701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="42"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000709701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51955" checksum="A8B736BB72C1405A" modified="2016-01-20" version="1">MNVSEQDLEYFLSSRFATHRYLINTATIITLYSTVAVVGFIENAVIFATLVAIGDLRGGSAANVFVGALTVSDMILCVFNVPTQNSVRAHKHIFCWLQLYYELGEPSEMSAMACRVLFASLGVPTHVSCILILLIAIDRYRNVRFPTVFASSAAASVSSAGSGGSSIAIRPLRSATALFLVFLSVVFSILAAFPVAYYTDVQQVSPQTFAVDLNASLLPFNTSSPDVVAPSDRDVSGERHFPMYCVEQWPSPLQRLIYSVLVVIGQFLTPLIVTLILYAHIGWWLAHRRGQLYHTQKTSAGHIHLAARLEVRTRRTHRILVGIVACFAGCWTPWTLYSLYLECTVFAIADVPVEEMAMVDPGNQNITVNANLKTTDLVLKANPLRYHSFDEVTEEISPMVTIARLVLCVSLFALSSTCANPFLYGWLNENIRKSIIRRTGLCMKKSPHYNQTSMDVNSSHIDKAHSFAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X246</accession>
    <name>A0A0R3X246_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7321</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020362">
        <property type="protein sequence ID" value="VDM31685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X246"/>
    <dbReference type="STRING" id="6205.A0A0R3X246"/>
    <dbReference type="WBParaSite" id="TTAC_0000733601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000733601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000733601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056496">
        <property type="entry name" value="CS_DNAAF11_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23602">
        <property type="entry name" value="CS_DNAAF11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 11-like CS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000733601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17029" checksum="D7119D308BB4B9AB" modified="2016-01-20" version="1">MDTSLIDCDVQTNYVRVTLRNKVFQMALPEEVHPDRSSVQRSRVTGRLLVRMPKVISSSMIELRNEEWKRTNECTETTEAKERRKGNVSNFLTVGEAKVSVDWRNITNAGDRRPSNLQMEKRTPVSLRKERENSPNFIDNLDVPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X298</accession>
    <name>A0A0R3X298_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC2_membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7387</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020367">
        <property type="protein sequence ID" value="VDM31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X298"/>
    <dbReference type="STRING" id="6205.A0A0R3X298"/>
    <dbReference type="WBParaSite" id="TTAC_0000740201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000740201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000740201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000740201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25320" checksum="ADD91C0487C044BB" modified="2016-01-20" version="1">MKRCALLIHVVWQHFMYQNLLFTLNPFLDFYIFYSPPVRAWVRRNTWFYYLAYAVFFATYIALACCGNIRRKFPGNFIALGVFTLALAYMAGTLSAMYTVSSVLVCLLITLGVCVSVSIAAICCPCDITKCQAVIAFLSILLFIFGIAVMITYFVAGYNQVGAHSVPLFKLLSSFSPYLAYDTQLIMGNRELALSEEDYVLGAMQIYLDVAVLFMIFLGLFGQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2L5</accession>
    <name>A0A0R3X2L5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7522</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020379">
        <property type="protein sequence ID" value="VDM31916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2L5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2L5"/>
    <dbReference type="WBParaSite" id="TTAC_0000753701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000753701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000753701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CHY-type" evidence="11">
        <location>
            <begin position="615"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000753701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="722" mass="80442" checksum="51284F925C929EBB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2W5</accession>
    <name>A0A0R3X2W5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Delta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7642</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020390">
        <property type="protein sequence ID" value="VDM32058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2W5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2W5"/>
    <dbReference type="WBParaSite" id="TTAC_0000765701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000765701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000765701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258150at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
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    </dbReference>
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        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5043133125" evidence="6">
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            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="294"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000765701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37745" checksum="65FD696A3C2486A6" modified="2016-01-20" version="1">MEVSALFRFLLMLASISLAVLSQEMVGEVRLSFYFESQDGRLLHGQTCDPWPYTKCDVYLTVCISSQGNGSCDVYFHRTGLWENANVGQAAISFPLKSPVPKILDVAVEVWDEDTSKSPDRIAKFRGNLVVAEMQNTPSAFHMAREEIVFANKARLESYGHIICARFYYGGDCSRRCIPDPERYACDANGYKKCRRGAEISIVPFFFHTGPECHRGYNPCAPEYNTCSSHGTCSPAGDYNVSFQCTCDSEWRGIRCDQRVPPCLVAMLTNRTLCQNGGKCRDLSGNDGTYICDCPSGWWGRHCEKKTAVVYVSFTNILLSPTPFNFECLYAIIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3B7</accession>
    <name>A0A0R3X3B7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OCRE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7818</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020408">
        <property type="protein sequence ID" value="VDM32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3B7"/>
    <dbReference type="WBParaSite" id="TTAC_0000783301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000783301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000783301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241788at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000783301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="50202" checksum="6A44B45E18686404" modified="2016-01-20" version="1">MNGKLWITKYHMIHNHSPLPETIKIDQSVRRLQVQESGKDELVISDGIVTVTFSKLSTIDVQVVLDDIVDQLPKHSVSLDSSRGERSSDCHPWIGSPGKAQSRPMQERKAAARDRLAARTKKARGLKLAPCLRRLAELAAAGSGPDFHKHLGELEALVEIWKHGGISSLASGSSSGVYAGGNSVTPSQTDSIAIARAVESLFRKQKAMDNSTGAVTGTTVKLPGRSPKAAQIVTPVVTGSTVSVIQTSPQPVVLKQALGSQPGAFVNSSNVVTLPSTAVATLPKDVVIADAGNGQLQLINSASIITTTGQKGDNGVAEGQPILGYVIQPMTSLSGGQTIIPTAAMVTPTNFVPIAPKLPVSDSPMQSFQPIPPPPPKVVRPPMPICKPKVMKPRGRQPKLKSGLGEGLLTVPEGPAVTRFVDNGQPKPWTPMIMESESCSYFLFVEDANYYYSPEEDAWLPFDHRTMAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3H3</accession>
    <name>A0A0R3X3H3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7884</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020417">
        <property type="protein sequence ID" value="VDM32354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3H3"/>
    <dbReference type="STRING" id="6205.A0A0R3X3H3"/>
    <dbReference type="WBParaSite" id="TTAC_0000789901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000789901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000789901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000789901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15311" checksum="EE3FC9761565E81B" modified="2016-01-20" version="1">MHLLSCAKRACEAGIAACVPGAKISTISKAISQEVYECGCRVIAGIGGHGIGDFFHGPPHVSHCVFEEESVDAGLEMLPGHVFTIEPAIAAAAAAADPLCVDEVTEHVAMPTVLKDGWSVCTSDSALTAQFEETILVTDNGPHILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3K0</accession>
    <name>A0A0R3X3K0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7915</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020420">
        <property type="protein sequence ID" value="VDM32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3K0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3K0"/>
    <dbReference type="WBParaSite" id="TTAC_0000793001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000793001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000793001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="251"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000793001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61562" checksum="5B0E18DE038E250C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3V6</accession>
    <name>A0A0R3X3V6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">N-acetyltransferase ESCO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8039</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020435">
        <property type="protein sequence ID" value="VDM32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3V6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3V6"/>
    <dbReference type="WBParaSite" id="TTAC_0000805401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000805401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000805401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="10">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="11">
        <location>
            <begin position="200"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000805401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29873" checksum="CD01FA8DD7B77221" modified="2016-01-20" version="1">MKRTGRRSKTSSRNQMILDFGQKGFGAKRCKECSMLYVVGDMEDLKAHARFHASYLSPDIKVSRWQNQHIIEDFFDGSRVIEISLADRMGLQLYTKVASFMNRDLGQDCPFGAADIMPRLPSYLRIFIYIEGGRKTAVGCCVAEELTSTTVAQRGYQLRRLVGGPRSLLSWRVQNPLSVSTGSVERGLNKTNNDRITFPLCGIRRLWVASKHRRCGVGTILVDSLLKHLVYLTHLPRSNVAFAEPTASGAEFAVRFVGREDFIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4E5</accession>
    <name>A0A0R3X4E5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8264</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020474">
        <property type="protein sequence ID" value="VDM32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4E5"/>
    <dbReference type="STRING" id="6205.A0A0R3X4E5"/>
    <dbReference type="WBParaSite" id="TTAC_0000827901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000827901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000827901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000827901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="14499" checksum="76E8C1A102E2EA17" modified="2016-01-20" version="1">MMSSEPSYAPFFGIMGATASMVFCAFGAAYGTAKSGAGICSMGVMRPELIMKSIIPVVMAGIVAIYGLVVSVVISSLKQLGGGLSVGLCGLAAGFAIGIVGDAGVRGTAQQPRLFVGMVLILIFAEVLGLYGLIVALILCNSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4R7</accession>
    <name>A0A0R3X4R7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020499">
        <property type="protein sequence ID" value="VDM32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4R7"/>
    <dbReference type="WBParaSite" id="TTAC_0000841901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000841901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000841901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6243570at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000841901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36028" checksum="164EC38666C75E06" modified="2016-01-20" version="1">MANTGRERYMKGDILRIPMEVGVKICKYLNATELMNLYSAIPQWRWILYTPPFAYIVREMMEEWKWIDKHICLLLFSGDAEITHTKAVLATAYHNQQDALHHRLVHTKLPEYAQKPVHCLFLTSRSDTSRLEDNVKEYQCDLQVLKHESPTRIYFDVTNDAIHFFRNWQRSSQASGGSCLQKLTHVAGSGREGEGRRLLTDYDCVIIDADYGDDNGIYSDMDELLLSMTASQTFVTTGSLLYIKGLVSNLDCMKEMLWSLDGMESSPLPQVAANWRIWCNQYQNNFGIDLVEIVRWTCLDIIVRRSGETLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X532</accession>
    <name>A0A0R3X532_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GT23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8540</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020526">
        <property type="protein sequence ID" value="VDM33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X532"/>
    <dbReference type="STRING" id="6205.A0A0R3X532"/>
    <dbReference type="WBParaSite" id="TTAC_0000855501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000855501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000855501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6435034at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11300">
        <property type="entry name" value="Fut8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045573">
        <property type="entry name" value="Fut8_N_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027350">
        <property type="entry name" value="GT23_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19745">
        <property type="entry name" value="FUT8_N_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51659">
        <property type="entry name" value="GT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GT23" evidence="4">
        <location>
            <begin position="187"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for donor substrate binding" evidence="3">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000855501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="586" mass="66285" checksum="8A6DD0E23D05C9B9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X585</accession>
    <name>A0A0R3X585_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8594</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020541">
        <property type="protein sequence ID" value="VDM33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X585"/>
    <dbReference type="WBParaSite" id="TTAC_0000860901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000860901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000860901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077228at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000860901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="798" mass="88528" checksum="A042A0AF0DB5E696" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5D2</accession>
    <name>A0A0R3X5D2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein yippee-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020557">
        <property type="protein sequence ID" value="VDM33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5D2"/>
    <dbReference type="WBParaSite" id="TTAC_0000867001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000867001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000867001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000867001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12625" checksum="961627977D9F3C0D" modified="2016-01-20" version="1">MLFGMNEAMERSRRFWDLNRGEWVPLTRGGYRCCRCQVSFTLEKEASPEESSTCKLPQVTVKAEVTPFQKTERRSGRIKQFTTEMRGSRFESVYLTCKCMHKEVSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5Q0</accession>
    <name>A0A0R3X5Q0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8793</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="UYWX01020589">
        <property type="protein sequence ID" value="VDM33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5Q0"/>
    <dbReference type="STRING" id="6205.A0A0R3X5Q0"/>
    <dbReference type="WBParaSite" id="TTAC_0000880801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000880801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000880801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="162"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000880801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="35482" checksum="BF6A5AAF8DFF068F" modified="2016-01-20" version="1">MCAGRLLLPLETGSYHGHEPKISVVGAGSVGTAVAFSIMTKNIANTVVLYDIDKDKCEGEVMDLDQGSLFLESCKVIGGDDVTKTANSDIVIVTAGARQAVGESRLNLVQRNVDIFKKLIPALVKQSPDCILVIVSNPVDIMTYVSWKLSGFPQHRVLGSGTMLDTARFRHILGQKLDVHASTIHGYVVGEHGDSSVPVWSKVTVGGVSLSEAYPKLGQPGDPDDFASVHKAVVDSAYEIIRMKGCTAWAIGLCCASLCNAILRNKKIVIPVSTYLKDKLGIKQEVFTSVPCIIDSSGVSAVVNLDFSPIEKQKLMASVNTLQGIIADIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5X5</accession>
    <name>A0A0R3X5X5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8876</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020615">
        <property type="protein sequence ID" value="VDM33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5X5"/>
    <dbReference type="STRING" id="6205.A0A0R3X5X5"/>
    <dbReference type="WBParaSite" id="TTAC_0000889101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000889101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000889101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000889101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15492" checksum="0B1177798CF5DD49" modified="2016-01-20" version="1">MLNTQRSNSTTSGKYTFEEQPLSSHSPATRQDRRLVTYTCEKNQFLEDGKPVKATIHCSEMTPEMEFWAVDCAAIALVNHASIKQAAAYIKKEFDKRFGPSWQCVVGNSFGSYVSHFEGSFIYFILKDFTVLLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6M6</accession>
    <name>A0A0R3X6M6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020694">
        <property type="protein sequence ID" value="VDM33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6M6"/>
    <dbReference type="WBParaSite" id="TTAC_0000916701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000916701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000916701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272197at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000916701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="830" mass="92990" checksum="72DADC05151714E6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7R9</accession>
    <name>A0A0R3X7R9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9579</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020898">
        <property type="protein sequence ID" value="VDM34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7R9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7R9"/>
    <dbReference type="WBParaSite" id="TTAC_0000959401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000959401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000959401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133220" evidence="10">
        <location>
            <begin position="25"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="315"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="422"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="565"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="667"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="787"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000959401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122951" checksum="6A4EE8083FB809B2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Y4</accession>
    <name>A0A0R3X7Y4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS9644</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01020955">
        <property type="protein sequence ID" value="VDM34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000965901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000965901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000965901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000043">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="105"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="781"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="941"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="543"/>
            <end position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000965901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="993" mass="110036" checksum="345741F7E66BB51C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8M0</accession>
    <name>A0A0R3X8M0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9880</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X8M0"/>
    <dbReference type="WBParaSite" id="TTAC_0000989501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000989501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000989501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
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        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
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    </dbReference>
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        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000989501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15580" checksum="A5BFC3A8A7C118A1" modified="2016-01-20" version="1">MANDKIGSLTPAYVPMQKLSNKRRPMSGKRIIERALSQSKLTKKQKESIKRRAHLKRKAVKKPRFPRMYSVQNPKRKLQLRKVQCFKDHRRRVRKSITPGKILILLAGRHRGKRVVFLKMLSSGMLLVTGEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8P1</accession>
    <name>A0A0R3X8P1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9901</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021146">
        <property type="protein sequence ID" value="VDM34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8P1"/>
    <dbReference type="STRING" id="6205.A0A0R3X8P1"/>
    <dbReference type="WBParaSite" id="TTAC_0000991601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000991601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000991601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000991601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38960" checksum="492AE6F5900525CF" modified="2016-01-20" version="1">MHMNVTVIIPERRHSVPEGRNIALADSANIAQEDTFHIPSPKPILTDFGMSVNPRSSRFIGLLVAYILITLLVVYMVVCAVCFQPRKCLSLVGRDADGEGESFSSPTPPPPSARTSRSRRFTWRWLQPRVSTNQTASVPLVLPRTNPHFSRSVNGERFLHYPVHFRIAPNLPSTAVESPTENWNTSNPSHHPHHQPQRHQQTGRISLAKARCNSLCGSAKISHISYNSAEMASHGATARIRVYDSSVFDLIDELSPFDNYVGSADAVKASTDCKVPDPINWFCGVLVPPQLRLAQVSFRRSLRLVAELATRRAALLQSAKQLSDLIGARDRLDNESLVPLIPAPTPFSQTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Y8</accession>
    <name>A0A0R3X8Y8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ecdysone-induced protein 74EF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9998</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021226">
        <property type="protein sequence ID" value="VDM34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Y8"/>
    <dbReference type="WBParaSite" id="TTAC_0001001301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001001301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001001301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001001301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16368" checksum="5E618DAC812F8D35" modified="2016-01-20" version="1">MECRFLHRQCGVFSNLTINFLLSKGYLSGYYAVEGCQVQHHSPYSLQHQQQQFHISVDPRQTSGEQSAAGGGGTSGGSSSLSSHHLRYQPFATCSSLQPQTHLQQQGGAVSGSAGSNGHSILTSNSPPLIGPHGYLTGSVHCLFPLFPLTNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9R4</accession>
    <name>A0A0R3X9R4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein VTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10274</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021498">
        <property type="protein sequence ID" value="VDM35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9R4"/>
    <dbReference type="STRING" id="6205.A0A0R3X9R4"/>
    <dbReference type="WBParaSite" id="TTAC_0001028901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001028901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001028901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001028901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23691" checksum="EB9CA2ED235F0D14" modified="2016-01-20" version="1">MGLKPEFKCKESREYITKLLDYLGEAKEANSGDPLYTDEKVGLEYIERQALDHFTVAFRKDEAGDFGPATVSSFLIAAALLEVLTLNGETNAELTNARKYAKYKILYLIDCKKRNVKPVAGPLTDGDASVIPNIAGLHQDPLPSSSRKSQQDSELAEPTGHESKSNGENKSEELSSDVCEKAMKAAKFAISSLQYKDRDSAINYLKEALNLLSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA76</accession>
    <name>A0A0R3XA76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10436</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021699">
        <property type="protein sequence ID" value="VDM35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA76"/>
    <dbReference type="WBParaSite" id="TTAC_0001045301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001045301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001045301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001045301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10757" checksum="CDC64BAD6FF4C8F9" modified="2016-01-20" version="1">MSHLLTSPDITPPPSSIHPPHTFQCHMLSPSLPPSLPPSPPPPPQAPHARITTNSTFTLASPHIRWSQSDDKPHTTPPPLPPPPPATHTAWSCHEDVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA90</accession>
    <name>A0A0R3XA90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021713">
        <property type="protein sequence ID" value="VDM35430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA90"/>
    <dbReference type="WBParaSite" id="TTAC_0001046701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001046701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001046701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001046701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13463" checksum="4900AED444F5D240" modified="2016-01-20" version="1">MPTSSLPSAGCDALDALVRVVQHDGKLSSTTACGQTSGVLLIPVAVRRDDDDDDDAVSSSHLLLPPRLSSSRLVSLVIHVVVIVSLSRLPLIPSLLPFFIPPFAPTPLRETHTRSQAVLHHPTYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAU7</accession>
    <name>A0A0R3XAU7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vezatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10656</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021999">
        <property type="protein sequence ID" value="VDM35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAU7"/>
    <dbReference type="STRING" id="6205.A0A0R3XAU7"/>
    <dbReference type="WBParaSite" id="TTAC_0001067401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001067401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001067401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001067401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54482" checksum="58C315C6389661D5" modified="2016-01-20" version="1">MQARYVSNSSEVGDERGSWSSSSAGGLAAVATPTPELPSRFRFHHHYHHHSKAGHSPIPPSLPLQSPLTISPSKYHHHHHYFRSPEWHNHNDAFTHPHSVPPENYRPFPCKTLGIESYVTENLLLSAHIANSKVKSQQLTELPLFQRRCAHALADMIVSPHTILPALIGVFLRPDGTRRSAFNKQLSVYLKAAYRRTAKKPRGLQSKSDIPATLLPTILALLFSYICGLIFGWQLGLTIGLTSVTLYLTFLCVVLYGGLVRRWRLAQSVAETLLRYARSWRLLVDILFYRPPEQILVPTNVRLKLGASETPWEAVIRLSEKVWEAASSKYSATAVYLQYANEDASCQGKRRCRKACCVPALGCFILWILSLLTWSTVLRVYMNSGESADQYRHGSKIAFIVSGAVALLSLLTLLAASLKSVRRLTRIHQRFRSLIKQRNQLLRCTPDSKEAKIVSCHQNTAAAFTNSASLKLTQTGHSRARLYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBC8</accession>
    <name>A0A0R3XBC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polycomb protein SCMH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10838</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022338">
        <property type="protein sequence ID" value="VDM35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBC8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBC8"/>
    <dbReference type="WBParaSite" id="TTAC_0001085501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001085501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001085501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2390104at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF132">
        <property type="entry name" value="POLYCOMB PROTEIN SCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="MBT" evidence="2">
        <location>
            <begin position="148"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001085501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="37359" checksum="4FAB298580482DF5" modified="2016-01-20" version="1">MPNIIWIDHNGPVENLLQNRTPPENLFQVDSLLEAVDQRIALNETPPPQPPSSFSISVGTAAGPSNGVASSSAASTSASSEATSSTAASTSPALSSASMAPRRRRFSVTGGGQQLRRFRSTPFSLARVIETAGPRLRVRLVGTDDRNDCWFLVDSDEIRPYPSHETLQPPFGYVHNHLPPPDPERNLFKKGDKLEAVDRHNAQLICPATIGEVSGLHVLVSFDGWSGNFDYWTRYDSRDLFPCGWCKLAGHALQSPGPAAIQHLNLTPTKMPVPRPLDPSSASSSSLPKLLASVQAHANPITVSVRRSASSRRKRCVLSNFYGFKEFPIKVDSHFSPFQSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBL4</accession>
    <name>A0A0R3XBL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10923</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022535">
        <property type="protein sequence ID" value="VDM35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBL4"/>
    <dbReference type="STRING" id="6205.A0A0R3XBL4"/>
    <dbReference type="WBParaSite" id="TTAC_0001094101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001094101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001094101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001094101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22720" checksum="B7E997A622F7E506" modified="2016-01-20" version="1">MVDLASLATGVIFNPNLQNTNDFNAKQLENDEKIVLKSGDVDYLIYTLDGIVCGGADGRLSTIQQMALAQIYFLDEEVFVALKSDHNAILYITACPSYQNFAILRKSGLVQIFQRDVSKEVNPSLLLQPIKEVRTNVSPFNGICGMNIEDDTYFVVTCMRVIPGLPLAAVGLQNGSMCVVYWVDRRTPRIMATRQIFQSAIEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBL8</accession>
    <name>A0A0R3XBL8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10928</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022545">
        <property type="protein sequence ID" value="VDM35908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBL8"/>
    <dbReference type="WBParaSite" id="TTAC_0001094501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001094501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001094501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133296" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001094501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20020" checksum="298688FD39AA2D57" modified="2016-01-20" version="1">MCILDEQLLVKLLVLVAVPLLFASSSSSSSTFIPPLDGALQVFFVQYVILAKIALTPSTKRKEKASKKHAGFLPLQIGEISGSKIWVRCASLSTCRRLHGTEFRQPFYSSGARRKLDAITGGTGRVIDENGEPFKEHILLKGVAVLVLISPSTSDAPDNCAPLAVTIAGSQVARAWQLDESFVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC84</accession>
    <name>A0A0R3XC84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS11144</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01023053">
        <property type="protein sequence ID" value="VDM36124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC84"/>
    <dbReference type="STRING" id="6205.A0A0R3XC84"/>
    <dbReference type="WBParaSite" id="TTAC_0001116101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001116101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001116101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM36124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001116101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13911" checksum="168EC7D3FCECE7C9" modified="2016-01-20" version="1">PVEWPVRLDVKDEDADFGIGIFSRGDGSVNKVGDSAATHQRTSRHRQQLEQATQHQDHQQPKKQRTAFTRQQLETLEGEFRAHAYLTRLRRYEVAVALGLSERQVIRTFVPKEEKEVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCD0</accession>
    <name>A0A0R3XCD0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11190</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023160">
        <property type="protein sequence ID" value="VDM36170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCD0"/>
    <dbReference type="STRING" id="6205.A0A0R3XCD0"/>
    <dbReference type="WBParaSite" id="TTAC_0001120701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001120701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001120701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001120701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16381" checksum="D0075E7FB466B167" modified="2016-01-20" version="1">MSLSFDDRILGEKVDNYCSSSDEADSDESNDEEVSKGVPVAVASRFSDTLSHQVAQTGPKGVIADYKQYRRLRDEQEKLKIETASRIARKCALTSRPYSADQSAKEEEQQLKEMLESLMDDDDAFLMQYRQRRIAEMQGMLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCP0</accession>
    <name>A0A0R3XCP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11299</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023533">
        <property type="protein sequence ID" value="VDM36279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XCP0"/>
    <dbReference type="WBParaSite" id="TTAC_0001131701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001131701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001131701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001131701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18054" checksum="249151C7B7156F8C" modified="2016-01-20" version="1">MNRDQRVQDNWALLFAQRVAXXXXVCYNLVASPALRTRRHVNFLLEGLVEVEKECKDLDIGFHLLPLHAAKSRSVEKGGAGGDTEVHGLDAEKVELLADALKQLEAGVVVTDFSPLRDDQWAVQRLSSRLPQDTSLYQEESCQFFVGVNCGVKWMWEGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCR8</accession>
    <name>A0A0R3XCR8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">28S ribosomal protein S9, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11328</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023670">
        <property type="protein sequence ID" value="VDM36308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCR8"/>
    <dbReference type="STRING" id="6205.A0A0R3XCR8"/>
    <dbReference type="WBParaSite" id="TTAC_0001134501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001134501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001134501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001134501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39483" checksum="2E79B0FEC41B05EE" modified="2016-01-20" version="1">MVGLLNGLISAAENMLEEERVKYDSGRKFLARLIGQNLSTFNQEGIDEAIRYLFPSSLASRKAHPKLKSPEEVYPEKKRIQFDKTGRPFHDLYYTGRPAYYEVMHKATALLEELNGKFDRGYIYRDYTAFKNPKPLVVAASEWLTKEQLRRKLLEPVSDTMYEDWMRLMNALLKHPLSWHAEDFIHSFRAAIQEATYKDVFPEPQLDPEKHSRYVVTYGQKKHAFVELRMTHPGVGRFTINDKQLLEYFPHLGDREQIMFPLQYTDMLGAVDVVTRVASDTETGHSSKANALRLALARALACFLPGDSGQNRLRAAGLLTQDDRFSERKKPGQKKARKKPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCZ0</accession>
    <name>A0A0R3XCZ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS11400</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023983">
        <property type="protein sequence ID" value="VDM36380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCZ0"/>
    <dbReference type="STRING" id="6205.A0A0R3XCZ0"/>
    <dbReference type="WBParaSite" id="TTAC_0001141701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001141701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001141701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM36380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001141701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15204" checksum="927FA879769BB786" modified="2016-01-20" version="1">MSVPRGISTSLLPSVFFGLVSATSSSLYALFWQGDPCAKYQVAQSLSILPACVVAAASGSSSAHTSPVSSTENSLHPHDEQQRQGRCHNYSYDCSIAEASDIGQRPVVLIRRDDFYRKILHNTVSLAAVLCVGLAVYRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDK5</accession>
    <name>A0A0R3XDK5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11615</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025759">
        <property type="protein sequence ID" value="VDM37386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDK5"/>
    <dbReference type="WBParaSite" id="TTAC_0001163201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001163201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001163201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001163201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8723" checksum="E7E27A8DD49A7CAA" modified="2016-01-20" version="1">MEKHLTFIQSPTTGADVSQHREHVDDYCSSQHRATDLALRPQQHSVGVTISQPSTCAVTEMVCEAGLLVVTVSTSIEVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDH7</accession>
    <name>A0A158RDH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS634</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000069">
        <property type="protein sequence ID" value="VDM16770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDH7"/>
    <dbReference type="WBParaSite" id="TTAC_0000063301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000063301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000063301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="704"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000063301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1627" mass="180909" checksum="57B75CDBC62158CC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDV9</accession>
    <name>A0A158RDV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6154</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDV9"/>
    <dbReference type="STRING" id="6205.A0A158RDV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000616901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000616901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000616901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000616901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47116" checksum="6C776B8657A63A25" modified="2016-06-08" version="1">MASPRTRHALAEVRRIEENNFCFECGAPNPQWASVTYGIWICLECSGKHRGLGVHLSFVRSVTMDKWKPIELEKMKVGGNRKARLFFEQQPDFRSSWSLSEKYNSRAAALLRDKVSTEAEGLAWSEETSPANNYRSPQRINRSVTATSLPSTRPRDITNPRVLPTVHSDLESWLNESEQKTRTEDFFSRMMAENANRPSGLPPSQGGRYEGFGNTPVPHKPEPQSSAYDDALKVLMNGWSSFSMFASAAVKKTNELAVTATEKTKQLGQSVQSKMQSYLQAPSGTMQTPEDCTQRHLQHNSQSFDNSTITNVPLNSNYGSLSTDICRKVKSFDEDINGGDGWGDDFSRGNSTLTEETKKSPLKEESNDWWNSEWDVDDAGRGWSDLSGKVGISITSAARQSVMNQRFSETASRRNKTGKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE54</accession>
    <name>A0A158RE54_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TMF_TATA_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6651</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020313">
        <property type="protein sequence ID" value="VDM30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE54"/>
    <dbReference type="STRING" id="6205.A0A158RE54"/>
    <dbReference type="WBParaSite" id="TTAC_0000666601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000666601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000666601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="3">
        <location>
            <begin position="806"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="882"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000666601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="918" mass="100975" checksum="742417F29D781C86" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EWW5</accession>
    <name>A0A3P7EWW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005588">
        <property type="protein sequence ID" value="VDM25823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EWW5"/>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="202" mass="21799" checksum="D6E12FABF2E476A3" modified="2019-02-13" version="1">MVRIPNWPALVEDAICLLRGPSQRTPKAALPPALAIATTPCCATGDDLLAMAAVSPTKGRSRSPAVRLQAAHPSISPRSSLLPNRSASVTPRTAVFEPPTRDSSGCVFQGQLSRRSSIDRFSHLIPGSPTPSALDSRTIVTPPFPHSQLSLMYTHNVVFAYIVFNEFCLELAGLCCEHSVSVASVQPQFEKTMELERCLADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXR4</accession>
    <name>A0A3P7EXR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010079">
        <property type="protein sequence ID" value="VDM28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXR4"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="71" mass="8217" checksum="6B59002C17B0743A" modified="2019-02-13" version="1">MKKYMATRPKASAESVRRAKELRLHISTLTPHPIFATQLSNVDTQKEAILEVLRNRKLPVRCTEPMILTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F123</accession>
    <name>A0A3P7F123_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008448">
        <property type="protein sequence ID" value="VDM27403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F123"/>
    <dbReference type="OrthoDB" id="6282689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="134" mass="14737" checksum="B516E928346FB0FF" modified="2019-02-13" version="1">MVTASIAGSIVAIMTVFVIILSCGSCRDSSSCSRAMSRFALAYILLDVLALIANIVSMAMWIQMKEKSEYAPSFWVGWTANGLLLILLVILIILRKCGDEDEGFGDHKSQVSADQPLFRSLYQVTPTTVFHNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FAR9</accession>
    <name>A0A3P7FAR9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005674">
        <property type="protein sequence ID" value="VDM25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FAR9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="106" mass="11676" checksum="04706D4103784243" modified="2019-02-13" version="1">MVAHHPNPPTILSPLRLQMPIMEVLVAAVEPRKSLPLGLLISPMLTRLKPVAWQNLRLAMLILRKVDSAALSTRSEAMKLPHGDAAHSALLVVEVVGETQQRLRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FF90</accession>
    <name>A0A3P7FF90_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat POC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020327">
        <property type="protein sequence ID" value="VDM31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FF90"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="447" mass="49304" checksum="60C0D691D91B8018" modified="2019-02-13" version="1">MMLWNIKPQTRAYRFTGHESAVLCACFSRSGEIIASASKDCTVKLWIPNIKGDSITFRAHTAAVRWVDLSQDGTRLCTASSDKSVKVWNVQRQKFAYSLNKHVNWVRCCKFSPDSRLILSSSDDKTIRLWDCRNQECVNVFSDTGGFANHIDFHPSETCFASGSSNTTVKVWDLRMRRLIQQYGDHTASVQKVSFHPSGIYLLSASEDCTMKIFDLLEGRPIYTLSGHKGAISAAAFSISGELFASGGADEQVFIWKTNFAEFSESPNCARDSVMASTHVRKSILTERWPLPDIYCSKRYTDDDGNANSNTDQILASNSQRHMDGCIKTAADVESSSFTATEPSKNPSSLPLSSRANQQQEGGDATPAERSAHISIKEKVSSVPECIASTLATMTAQLNILTQAVLIATVFIPGRHIIATPWSVFTAQRGTFLLTRAASHNRAIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGK9</accession>
    <name>A0A3P7FGK9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021476">
        <property type="protein sequence ID" value="VDM35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGK9"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="158" mass="17841" checksum="A2A53D6C51635110" modified="2019-02-13" version="1">MDKTCQKNSPAPLRAPPHKYTSGWNHGESQMYDKTSLKSSPGCVKVLSVDVNPLSPLRNAMQGISDVPSSVLSGSEWYETQAYRALNQALGRCIRHRGDWGAIILAEARFVEQPERYLSGISRWLRNHFHHDIGRFCLSQIRGSREVVRFAGGFEQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FRI5</accession>
    <name>A0A3P7FRI5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023483">
        <property type="protein sequence ID" value="VDM36263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FRI5"/>
    <dbReference type="OrthoDB" id="414039at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49349" checksum="B0AB40B30C3EF882" modified="2019-02-13" version="1">MGTIIQNQGCEGSGEGNISDYIRVAQQLRTGLDDNWSRVRMAALKTTRLLFQVPPPLGQSHESVYPILLPPLCLSRYYVAEGVKVYSQQTWCEVTGGRGREILTRILEPTLEYFVEESRSENHAVREAACACMAEVGIKLPRGDLRPHLNRLLGALTVCFKDQSWPVRDAACIGLGNLVSVFPTETRAAGYADLMAERFLHNLVDCIPSVREGAAASIAKVLQGANDSELEKMYLDFAEKQLDGIVDQPADSKGAASMSRGPGANVVVRSGNEAHDEKHTNQVMYSCGSLATRANKGKYSTCGGGCCMDDTFQRPSQLWERADGAIRLIGEMGIYAPQKVTDRLLEKMVNAASLTHYPHHPYLLETACYTIKALCEGQQKSDFKRNLDFLLPVIAWAVSTNQPLAVAAAEECLATLSQVLGPSVLRSRIEGHLESTIVPRLLNFLPPSGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FUQ1</accession>
    <name>A0A3P7FUQ1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020491">
        <property type="protein sequence ID" value="VDM32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FUQ1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9317" checksum="4BCF817350F5E287" modified="2019-02-13" version="1">MINSMLTMNPSKRITAAEALKHQWIFQPERVASSMHRQETVECLKKFNAKRKLKALSVFGPDHQKWRPAEMGKELGSSHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G1S6</accession>
    <name>A0A3P7G1S6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020824">
        <property type="protein sequence ID" value="VDM34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G1S6"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="807" mass="89594" checksum="16449C6E9C4B9D18" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G5F0</accession>
    <name>A0A3P7G5F0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM36574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
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        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
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        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
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        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
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    </dbReference>
    <dbReference type="Pfam" id="PF00079">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19452" checksum="40FD550A45A2FD1C" modified="2019-02-13" version="1">MQVHKQQFKDYDSTLANLGSHLDAVSRGDSDKTLVLANGLFLESTIEVNTFFKKALEKHFHADTHMVNFASNSEEARKQINAWVSDHTCKKIPDLMPRNSIDSQTRLVLANAIYFKGTWEKVFHREATTNWPFQTLHNGEVQVPMMSDNGVYEMCSFDELGASALKIPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G695</accession>
    <name>A0A3P7G695_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022243">
        <property type="protein sequence ID" value="VDM35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="1">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="188" mass="20901" checksum="A0ED6393118D283A" modified="2019-02-13" version="1">MGLTLENVTTEQDGQKLICEASTSYPPDQVAQRQHTEISVNYPPQVEFNQSLIHTALGVYEDIMVTVHGKPKAELLCDNMDLPGPREVEILPDEKRGVNRYLLHIQGVTKEDLGEHFCSATNKFGTAKKSFSLTLAPSKPEVVSPAFSSHADYYLLGWRAKSKSPLRNVTFRIQTVSSAITFSLLVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6W5</accession>
    <name>A0A3P7G6W5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000129">
        <property type="protein sequence ID" value="VDM17175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G6W5"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="780"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="800"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="836"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="887"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="923"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="959"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1253" mass="136169" checksum="0655BB9B76DEBE3F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G776</accession>
    <name>A0A3P7G776_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022977">
        <property type="protein sequence ID" value="VDM36087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="241" mass="26784" checksum="E0D2C69E510B5ACD" modified="2019-02-13" version="1">MRSALVSPSSPAVIPALPPNSTAFRLVNLASAVAAANVPVRDSTWLKMRVCPAFFKEMCPFTAETCSLAHPQPNVRIENESVTVCFDFIKVLLAICLKLVGRLSKGYYQLILLDSLVQLAKIDQKLDTRFSSGLISVRFAASKSLKALKPLHDGSSFCMIFLYREIGILAHLIRRTGLKAVASLWLGAASYLQLRLNFLLNLFEYDVWFVAVGSLHKWPILPRLPLLGFLKCVCSVXXXFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G7A5</accession>
    <name>A0A3P7G7A5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01025390">
        <property type="protein sequence ID" value="VDM37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G7A5"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM37224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="112" mass="12590" checksum="A6B198034193D7B1" modified="2019-02-13" version="1">MESFPNRCPTSNSCRPILGLRAVKLPSRQSTLFPYLILTVLLIRSLMLKGSLQGILYYLTPKFDRLKDPRVWVDAATQIFFSLGCCSGSLIAMSSFNPFKNNCCSAFSSYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GHC5</accession>
    <name>A0A3P7GHC5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002066">
        <property type="protein sequence ID" value="VDM22148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GHC5"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000083">
        <property type="entry name" value="guanylyl cyclase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="148" mass="16830" checksum="E1BB88840F009A59" modified="2019-02-13" version="1">MSKKKFIEVYSSFFPTGDADQFCTHVFRTFDKDNSGKIDFNEFLLAINITSGGQPKEKLEWAFQMYDIDGNGTIEKKEMTEIIKAIYSMLGANEATVDLTPEARTEEIFEKMDSNHDGVLTRKEFMDGCMADQQLYSMLLADESNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GM39</accession>
    <name>A0A3P7GM39_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003279">
        <property type="protein sequence ID" value="VDM23738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GM39"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13072" checksum="2CD82755A74B8E10" modified="2019-02-13" version="1">MLSCDPDLSAWHGTDPRTYVDEADAFYKDPIRWLNSNYPDSHTLPQHIAMFTELTQNADYGQAVMQWLRARNYSICMEIFHSHIISHYRHSRHIVMWCAEGWNLDLAEKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GPE8</accession>
    <name>A0A3P7GPE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003476">
        <property type="protein sequence ID" value="VDM23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GPE8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="161" mass="17965" checksum="BFD1AE2EDA9BBF52" modified="2019-02-13" version="1">MDEMRTISQQSDSTVPNDNGHARDLEVQVENLTNTLTTTQKALLVYIAIHDRPCTWDQVLHACTEFSPQRSAAVPWTAGGTTTNRNPIYCLEVTRSTEESESKATEALKLADLSSSRVEQLQQNVARLTRSLAAYKEKATTILSDKERVSLYPFLSLSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI34</accession>
    <name>A0A0R3WI34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fez family zinc finger protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS233</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI34"/>
    <dbReference type="STRING" id="6205.A0A0R3WI34"/>
    <dbReference type="WBParaSite" id="TTAC_0000023201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002009">
        <property type="entry name" value="FEZ family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26491" checksum="3D9361E7BC20AFF7" modified="2016-01-20" version="1">MPSLSFTIEGLMGSTHASSSSKNRPSPPPPSPPTSSKMGENAMEVARPIAHVFECPKCVKPFTCEICGKGFHQKGNYKNHKLTHSKEKQHKCPLCEKSFHQAYNLTFHMHTHSDEKPFTCYYCGKGFCRNFDLKKHIRKVHLRGLYDNHSGLRSLTQCLGKSAVTSLPSQPPFHSPLALPSLQMTPPTLGFCNMAPQESPDYAKPCLQLVQNEENLHVGFRIPPPEVLKKMLPDPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI38</accession>
    <name>A0A0R3WI38_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS237</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI38"/>
    <dbReference type="STRING" id="6205.A0A0R3WI38"/>
    <dbReference type="WBParaSite" id="TTAC_0000023601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="754"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="804" mass="89324" checksum="18428F027E259A33" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI57</accession>
    <name>A0A0R3WI57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS262</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000018">
        <property type="protein sequence ID" value="VDM16165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI57"/>
    <dbReference type="WBParaSite" id="TTAC_0000026101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000026101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000026101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6222294at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132875" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000026101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8748" checksum="1B0DBAB37843E400" modified="2016-01-20" version="1">MRAMLAVLFCALSFFACVSLAHPLSDEESLELFKRYFDPIRFAMGPIRTKEDLDKRESVIASKRYFDPILFKHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIM6</accession>
    <name>A0A0R3WIM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS462</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000041">
        <property type="protein sequence ID" value="VDM16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIM6"/>
    <dbReference type="WBParaSite" id="TTAC_0000046101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000046101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000046101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000046101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16590" checksum="9E28CFB56A45CE02" modified="2016-01-20" version="1">MIVNVSESEQTLELDYKNGDIVRWLDYDPKYLEPNAGPLPVDTFLECETLSGKNVIVHSENARLITSKIEMAKLLQRRPRAKVVTTSFCSTPEELSVEAGETIYILYECNSTDFMAVNKRSQCGRVPKRLLNFQAAPQLTSNRFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJC4</accession>
    <name>A0A0R3WJC4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcineurin subunit B type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS767</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000093">
        <property type="protein sequence ID" value="VDM16961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJC4"/>
    <dbReference type="STRING" id="6205.A0A0R3WJC4"/>
    <dbReference type="WBParaSite" id="TTAC_0000076601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000076601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000076601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000076601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19203" checksum="0666DB217FD67BAF" modified="2016-01-20" version="1">MGNEASLPELCSTFDVEEIKRLGKRFKKLDLDGSGSLSVEEFMSLPELQQNPLVARVIEIFDTDGNGEVDFKEFIEGMSQFSVKGNKEAKLNFAFKIYDVDKDGYISNGELFQVIVLKMMVGNNLKDAQLQQIVDKTIMFADQDGDGRISFEEFCQVVSGLDVHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJC7</accession>
    <name>A0A0R3WJC7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS772</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000094">
        <property type="protein sequence ID" value="VDM16970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJC7"/>
    <dbReference type="STRING" id="6205.A0A0R3WJC7"/>
    <dbReference type="WBParaSite" id="TTAC_0000077101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000077101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000077101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF5">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="11">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="12">
        <location>
            <begin position="420"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000077101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="705" mass="79453" checksum="FFBAA8F0938CB2DA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJR7</accession>
    <name>A0A0R3WJR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS931</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000132">
        <property type="protein sequence ID" value="VDM17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJR7"/>
    <dbReference type="STRING" id="6205.A0A0R3WJR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000093001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000093001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000093001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="423"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000093001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116710" checksum="17B22F873A863C41" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJV2</accession>
    <name>A0A0R3WJV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS970</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000144">
        <property type="protein sequence ID" value="VDM17249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJV2"/>
    <dbReference type="STRING" id="6205.A0A0R3WJV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000096901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000096901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000096901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06958">
        <property type="entry name" value="NR_DBD_COUP_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="185"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000096901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56808" checksum="36DB48CCEDBDB4EE" modified="2016-01-20" version="1">MSYTHTDAHGCMRPPNLLFPHLWVNPSPLRVEINLSATPLPGLIHIPEKKSQESDESKSKLDVIGAMRRKELEGEEDSVIYDCVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRQLTYTCRGARQCLIDLHHRNQCQYCRFQKCLRMGMHKEAVQQGRLSAAGHPYFRAFDRRSGGSSPASDFGAPSMDSTQTYSVFQMVAALLNADQTFDYPLTNTATLTTHYVRWAKQLPFFDTIHKVDQMALLNSALCDVILLTISQRWNYGIDLLGLHQSTNENKEKKYDLGRLHGIVNQVAALHLTFVESACFKAMLLFNVGNVLDMLCRVLNIILDLDKLVDPTPIRYAQIEVQTALEEYLHYTMSASQPSRLGFILLRWIGLRTTSFRALLVKALSPKDYSVELELHRALTSQADFTTMGHHIVNVPASSISLRSSKSYCNHPLPQFHSDRLNMISVDNSTKLNYVWRYPQEDQSSGMNHHFTFQSLCRSLRDRFVNGTPVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK55</accession>
    <name>A0A0R3WK55_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1086</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000176">
        <property type="protein sequence ID" value="VDM17438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK55"/>
    <dbReference type="STRING" id="6205.A0A0R3WK55"/>
    <dbReference type="WBParaSite" id="TTAC_0000108501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000108501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000108501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000108501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51644" checksum="D8DDC08B12698D08" modified="2016-01-20" version="1">MADNGAHDPGRGYVGNCTVLEEVENHVPTDEEVRMYAKAIGIDPDKEADLLYIAREGISAPVPSDWIVLQDRKGGIFYQHKPSGVCIWEHPLDAQFRLRVVEAKSKKLNCQKVKSGESAPALNESTPVKTETVYQALPTPRTCLNAKVGEFKVPSLPQKTANGLNTNLHSTEVDSPSTSVSERSFSAFNLPHVNLSPTCTSRQRKAFSEINANNGTSFTKASSQRSHDTDENAYPAASTDALVNLADRFTSAVRISVPSRNQSERHRRYSNTNSVRRLFYVPDGDVTSCLYSPPESPKPRPRHHCGDKVRPRTTETPVKPEMLASPAGKMMVELDGNLSVQYLLEEQKRLHEKIAFLKVTYKAYKLRLANVNASIKMIQSTAAAAAVASSPTFQSHSAVIDASGSGFRASPSNHSNSIANSAPLRPESTRRLTAESSRQNREMRQHHGSRRQRARSIQNGAAGTNSRSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKF7</accession>
    <name>A0A0R3WKF7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1196</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01000211">
        <property type="protein sequence ID" value="VDM17607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKF7"/>
    <dbReference type="STRING" id="6205.A0A0R3WKF7"/>
    <dbReference type="WBParaSite" id="TTAC_0000119501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000119501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000119501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="353"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="428"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000119501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="706" mass="77912" checksum="6DEB75239F2AE962" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL03</accession>
    <name>A0A0R3WL03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1419</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000303">
        <property type="protein sequence ID" value="VDM17962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL03"/>
    <dbReference type="STRING" id="6205.A0A0R3WL03"/>
    <dbReference type="WBParaSite" id="TTAC_0000143201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000143201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000143201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000143201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19489" checksum="D8BFFE944E118569" modified="2016-01-20" version="1">MDDRSSSSLRAILYDPNSNSNVENVLDVVAALVWDCNFQSAKNSRAIQSFVQRFSELANFIYSQRTKFTDFELVKVIGQGGFGRVQLVRHKDTRRVYAMKMMSKQHLLDHSQSGYWEERDIMVKATSEWLVTCHQAFVVCFCHSIHVSLHIFLIEKGHAYADKPLSFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLI4</accession>
    <name>A0A0R3WLI4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Filamin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1609</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000401">
        <property type="protein sequence ID" value="VDM18281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLI4"/>
    <dbReference type="WBParaSite" id="TTAC_0000162201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000162201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000162201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264520at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000162201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39532" checksum="3BAE418F758C92FE" modified="2016-01-20" version="1">MSEKQYARKALEEVIRLADEKIVATEEVVLKKEDDFNEFAHSCDDTVKDLEQYFLSIVRQLEKWKHVFIQELQASTSAAASEFQNRNAQIGELVGRLRELRETSAHILATEQFKNTDLVFDVHGCIFSINQAIENMTEFLAECVPLKFVGKLNFESVQKSDVGSMERLADNNYAEILPSKLPKIKLGQLFNLDFRISKKYCEAAKRFITYSVSKEDGQYQKVCAYLHDNKDGSYALSFPITAIIPHTVHIYYLGEHIRNSPYTIVFKVGQNQGGNAVGVGGQTSVTGFVGSSKDIMGDGANNSTRPMGKTGDDYRRNKWSTSSTDSSQNNNNWNQVMGSNISPESNQSSESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLN6</accession>
    <name>A0A0R3WLN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000434">
        <property type="protein sequence ID" value="VDM18358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLN6"/>
    <dbReference type="STRING" id="6205.A0A0R3WLN6"/>
    <dbReference type="WBParaSite" id="TTAC_0000167401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000167401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000167401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000167401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40379" checksum="0E0404468BD33E27" modified="2016-01-20" version="1">MKVKIVHNSQKLFNVNVTEATTIADLKQAISRHIGWSPEDQVLTFRGIFLEDAHPLGDYRLPKPDIVVPIVLYLRARYKKPASLRVSVSADKTIHLSICLDSKVSELRSAIEEKLNISAEESSKMRLIFDNWILNDSENLEHYGIKKNSCIIVARRLVNSPLNSTVESSEKLSMQNNVVPNIRLNVVTRDGKVFSFSFEKKITLREATEEIEKKTGIPATHQSFTLREDLPHVADLTRSLEQLGLSDGDTVYVADARSTDNEVDENGSQIPTSTTMVLHFRDAQNIFSIPMPYEATVQDAIDSLRKEISGNPGPLWLKNTVDGNYMQDYDTRLSDLGLKDGMTIEYVYLPAKTEWALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMD9</accession>
    <name>A0A0R3WMD9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF2052 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1914</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000602">
        <property type="protein sequence ID" value="VDM18654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMD9"/>
    <dbReference type="WBParaSite" id="TTAC_0000192701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000192701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000192701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132903" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000192701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12862" checksum="B060010B2C88DB87" modified="2016-01-20" version="1">MSVNFVIIQLISVAAITIAVPPNPKPSSVARDGTLPLLYGDPTIVGEETEEEEEEEEEEEDDDEEEEGGEDLDHSYLEYLKETFRRGRRNYFGFMDSDELYNAFPLPQPEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WML4</accession>
    <name>A0A0R3WML4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1989</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000665">
        <property type="protein sequence ID" value="VDM18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WML4"/>
    <dbReference type="WBParaSite" id="TTAC_0000200201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000200201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000200201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6222109at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132902" evidence="1">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000200201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31993" checksum="2045B553C39A8114" modified="2016-01-20" version="1">MQKLYYFLGLLLCLISLTTARQSLYVQNLKFLPPCENNPIDESTGNFKCMVKTGAECFALCQEHGCFEWSFTSFMASTDTQLHQHYRWRRIGPTLESGSGLGFASIAEAATAFVIVGFTHQSDPCLVPGQLVKKSGYHSERRTGKFLRRSASGAMTTIKSPDCLYTPTATINTDPVYTRHSTLCPLLHHLLFISANYYVHGLKFSRPCENNTYDEMTGNFKCTVPTGAECFQLCQQYGCYEWSFSSFMPSTDTQVRDHFRCRCIQDICLYNYVRVRDRDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMM9</accession>
    <name>A0A0R3WMM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clu domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2004</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000678">
        <property type="protein sequence ID" value="VDM18744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMM9"/>
    <dbReference type="STRING" id="6205.A0A0R3WMM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000201701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000201701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000201701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="320"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000201701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52790" checksum="60B82827049E92A2" modified="2016-01-20" version="1">MPDEHQSTMDEGSPNHDSKENLVSVDGIDGVSYFVNVVFPNSDTCKLQVSAGEIVQEIHRALMEREESCHRTCFSLHFNDQTLDLFTDLKSIEGLEEGSEIRVVEERYTTREVRNHVKHVLEILNSIKLRDAYAGREQMSLSFLSSVTLGDILDRKPNRIDPSSLSFLPPSYIMPAVANAEPPLLPLHPISKEDNDLDCLHQLNYSNWNPPPSSRRLAGDLLYLVVHTLEGKRCHITACPRGFYVNQTTDEIFNPAPVQNAYVVHSLVDLLKQLSPTFKKSYDTLLKRRANKHPFERLPTPYQVYSWLTPNWQHTLDSVRKEESLTSRMAWEENLPGQTRDWNDELQATRELPQNDINEQLMRDRAVFKSNCDFVAASTRAAVNVINGEIVAINPGEKRKQQMFIWNNMFFSLGFDVKDHYKDLGGNAAAYSATVILCLYGLSSPTVYHNLCGILQTVPLKFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN00</accession>
    <name>A0A0R3WN00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000773">
        <property type="protein sequence ID" value="VDM18965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN00"/>
    <dbReference type="WBParaSite" id="TTAC_0000213801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000213801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000213801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260950at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000213801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9683" checksum="F0AC047DBA410BA1" modified="2016-01-20" version="1">MILMSTTNARPVDYSEEANDEVFPRWRRPFFNPYPSWIAFLKKVYRSRHGIESADQLDKRPFFTAFPNYNTASGRRWSDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPP5</accession>
    <name>A0A0R3WPP5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2720</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001428">
        <property type="protein sequence ID" value="VDM20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPP5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPP5"/>
    <dbReference type="WBParaSite" id="TTAC_0000273501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000273501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000273501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000273501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32952" checksum="C56C9F9707F61890" modified="2016-01-20" version="1">MDKDDENVKHFNPNGLLRTGICFGFRQIVIGTLLRVQFPSNASNEALHLAVTYADRFIWTQETNPLGYGSMAHGALWLAVKVLTPETPVTCPLMEAMTSGYLTVEEIEEWAEYLRLNLGPDLHYPTPHSYLDKFLKESCDLPAYHIKLIIRVCHYLLDLGLMEHDLGRRPAYLRCAGMIYFLRRLLRFTGHVLGGSPSQHEYTALSYWPLELERCSGCKEDENLKEVASTYGRLLEETKKYQQQCAQSPLVFMPIVEKYLDRVYGGVAAHPLVTDFELEKVMCPNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQY4</accession>
    <name>A0A0R3WQY4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3159</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001998">
        <property type="protein sequence ID" value="VDM22071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQY4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000317401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000317401-mRNA-1"/>
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    </dbReference>
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</entry>
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            <dbReference type="EMBL" id="VDM24135.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000409701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9095" checksum="002532916813D35B" modified="2016-01-20" version="1">MGATKDPPHDATATRTGRCREGGRGGGKWGVGEWVEGEMRMEKEGEGDEVFGIRQSEKAYLYLVRIRFLLLFIPHGTVASIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTW0</accession>
    <name>A0A0R3WTW0_HYDTA</name>
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        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TTAC_LOCUS4186</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000420001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32934" checksum="7860EC2F4C3EEF46" modified="2016-01-20" version="1">MYASFEGCSKLPPLNLRQRAATARAPLKPRYSKDQHHDHKNGVCEYCWNLEIPRTPTLFDETTAGLSDNPFTEDDEAIDDGAFSDSSLSSCLDEEDLPYDYEFKNANCDFFEKQLKMVDAGRISVPMNCEVITRRRVIRRRIARPSPLPSFYQISYNSQEATSGSDSGFAFGAPKRAMSSANVTASQSWNYRNGMMSGPQSPAPGYSSIRSIGGSLRGGGMLSSSQGYSARRERLRQEAEQAEALRQSTQRINHVPAASSNDLRSTTLHQQRRQHYHSMSTIQVNISYANIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTZ3</accession>
    <name>A0A0R3WTZ3_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4218</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003937">
        <property type="protein sequence ID" value="VDM24454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTZ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTZ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000423301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000423301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000423301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="335796at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133024" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000423301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26304" checksum="AFE88B746355E7A8" modified="2016-01-20" version="1">MHLSLSLFHIALVTSLSEALSSEDREMLTFLHVSARLSVKPPAINMHPLLWSTELENLARTWAEKCLWGFPDPTIPDEKPLLYVGINVAMISTDELQGDKAPLPPVSILFNLWYVNTQNYDYELNICKGGYCSQYRQIIWAATEQLGCERAICGKGAKRHVLVCCYYPPGNYSELRPYQVLESEDDFPLDEEPWIMRPARIQNTTTKKNIGLSVIVANFELVLISSLVLMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU97</accession>
    <name>A0A0R3WU97_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4322</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004151">
        <property type="protein sequence ID" value="VDM24681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU97"/>
    <dbReference type="STRING" id="6205.A0A0R3WU97"/>
    <dbReference type="WBParaSite" id="TTAC_0000433701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000433701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000433701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM24681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000433701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10809" checksum="E6EBB9936EB50E04" modified="2016-01-20" version="1">MHNYSSQNKAVIKNADMVDEMQQRAVDCAQDAMEKFNIEKDIAAHIKKEFDKLYSPTWHCIVGRNFGSYVTHESKHFIYFYMGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUF1</accession>
    <name>A0A0R3WUF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mago-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4377</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004273">
        <property type="protein sequence ID" value="VDM24798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUF1"/>
    <dbReference type="STRING" id="6205.A0A0R3WUF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000439101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000439101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000439101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000439101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18136" checksum="469B1CE626B37E12" modified="2016-01-20" version="1">MQAARVGVVVNAKGEHVIPASRRPDGTWRREIKVKAGYIPQDEMPTYLPKSVEQMRQKRDAFVIPGLSKEDAIAITQHRRAAGEVTSNGQEPTSSKKKKNKSKAKIDSNGGEDHVSFGIYFSRLYYFMQHLLAIWGMSLTDLIIISSVIVTIGHNKYLLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXF1</accession>
    <name>A0A0R3WXF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5427</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007470">
        <property type="protein sequence ID" value="VDM26963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXF1"/>
    <dbReference type="STRING" id="6205.A0A0R3WXF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000544101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000544101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000544101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000544101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17892" checksum="3C37D5AB509016BF" modified="2016-01-20" version="1">MASRSDTHLHLRRPHLRTATFIPASFSFDLLGPSEKRNQWLPRLHDTLTDLLDAGSDIVISGRLLSSDKLIELCRGEWYFMNSLLSIGHRLAPFTSKEQRTSRLQAELGKLNFGLPARVWLPVETKEHIVLQIPPSAAVCLNSSEKVSYSIFLSPLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXQ8</accession>
    <name>A0A0R3WXQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lig_chan-Glu_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS5532</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01007868">
        <property type="protein sequence ID" value="VDM27171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WXQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000554801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000554801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000554801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM27171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000554801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13269" checksum="0678278EA5E69AF8" modified="2016-01-20" version="1">MQYGYWNEKDKLVVTKEFSTTQAEIYKELKDQVLRVATIEEIPFMMYKGPAGEKKSSNPKDWHGFCIDLLDECATALEFNYTVHPVTDGNYGTARIINGQEVWDGIIGQLQFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXY6</accession>
    <name>A0A0R3WXY6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS5611</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008213">
        <property type="protein sequence ID" value="VDM27319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXY6"/>
    <dbReference type="STRING" id="6205.A0A0R3WXY6"/>
    <dbReference type="WBParaSite" id="TTAC_0000562601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000562601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000562601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM27319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000562601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18599" checksum="DA0B367AFB68ADC1" modified="2016-01-20" version="1">MESATRRLETKQQTLEDAYSPPANFLEIDVCNPQVHGDAKSRYVDYEVKLKTNLPVFRLSESSVRRRYRDFDWLRSELDRESKIIVPKLPGKAWKRQIPFRADDGLFDSDFIEARRKGLEEFINKVAGHPLVQSEKCLHMFLQSDVIDRNYKAGKINQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXZ8</accession>
    <name>A0A0R3WXZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008279">
        <property type="protein sequence ID" value="VDM27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000563801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000563801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000563801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248103at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000563801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22002" checksum="2C5EF249034384CD" modified="2016-01-20" version="1">MWPKSEVKTRNVTATAYILGTLEKEEFGSGCLLPQPEYSDYYELRVVENALSLSENNATVCTIVTWTVDDASARSLLGYVLEITQSTANTCRLIWIPCVDCFPHHSLRNALPAVEEQLREIETQCTKVSTQLLQHAERLDSKLYRTTIRLVLGFQSSGETNDTFSGMVRVHAVKMGSVHQIMEHYWPSTAKGKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY38</accession>
    <name>A0A0R3WY38_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS5666</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01008493">
        <property type="protein sequence ID" value="VDM27414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY38"/>
    <dbReference type="STRING" id="6205.A0A0R3WY38"/>
    <dbReference type="WBParaSite" id="TTAC_0000567801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000567801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000567801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM27414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000567801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25421" checksum="22EF841B32CC91D2" modified="2016-01-20" version="1">MSGLTDSKPVGGGCDSGDHLESSADPSRPPAGPQSQTSGLRFAGKRQVVIQNLDLTPLRLDDPPTHHISASSNINANTSSKPARVRLPPLTSIGAAEGSTDNSSVLRNDRGGANKPNDRMSTGPVDLAAAQRQLDDQQLDDSQRERIEEFLRCKKDIHELHPEDFTKISELGSGNWGVVSRVRYNRTNIIMAKKTIRLDIKHEVGTQILRELEVGRHCSLIPRVFILGYPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY62</accession>
    <name>A0A0R3WY62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008568">
        <property type="protein sequence ID" value="VDM27441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY62"/>
    <dbReference type="STRING" id="6205.A0A0R3WY62"/>
    <dbReference type="WBParaSite" id="TTAC_0000570201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000570201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000570201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000570201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20227" checksum="901BD9A4F2D5685B" modified="2016-01-20" version="1">MEDRRHLDFNSEVAETSLDTTKLLDEIEELEARLNLPLSLKLCRSSLVRSLAADAWHLRTSKQSAFSKDPVPPDSSCFTKEEAMASQMHLISEMRQQAARKLKRISAKERTRIIDSVRIYSFDELLRQHIRVVAASRGDCDPDTDSTAEMDDIHLGFGQDLEFVTFCRDCLIESLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY71</accession>
    <name>A0A0R3WY71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5696</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008612">
        <property type="protein sequence ID" value="VDM27465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY71"/>
    <dbReference type="STRING" id="6205.A0A0R3WY71"/>
    <dbReference type="WBParaSite" id="TTAC_0000571101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000571101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000571101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000571101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15105" checksum="7E6DDF0DDD9B7372" modified="2016-01-20" version="1">MCWLLSTGHDARAWAMYIDEKRSWFLHNGEHFERTDGGITVGSVIGVRLDCERGTLAYYLDDEPHGPIAFTGLPAGVYYPAISLNRDVQVTLRSGLEPPSSDSEDSDENTSPCPPLTTASVTAPALALARPLSAKSAPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYG9</accession>
    <name>A0A0R3WYG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANAPC4_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5793</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009087">
        <property type="protein sequence ID" value="VDM27678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WYG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000580901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000580901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000580901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000580901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16239" checksum="E095EB7CCD74972E" modified="2016-01-20" version="1">MSTSAAPSSSTPTFASLGETEAVDQPVVWFHFFANLEHLQKCTEWRARLAWLSAGRDGLICGRSLAEDQWALSLLVHKFAEITDVDVDPDGRWIAIGTTDGTVSDEKNAFAILDRQIVFEYPHHLIPPISLVISSPKLHGLTILWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ02</accession>
    <name>A0A0R3WZ02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransf_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5976</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01010042">
        <property type="protein sequence ID" value="VDM28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ02"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ02"/>
    <dbReference type="WBParaSite" id="TTAC_0000599201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000599201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000599201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000599201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15319" checksum="F3E673BDC0947409" modified="2016-01-20" version="1">MRPRTLHIHLQRCPIADVPQDHDALRNWLTSRFALKDKLFADLEEVKKNRQRQPNVDEVKDAFLNNLSISKVPNGFDELPRLRRRWLFTAFICLATVTAFLLFVHPWLRYAYFGSVVGATLLGIPYVWLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZW0</accession>
    <name>A0A0R3WZW0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acidic fibroblast growth factor intracellular-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6348</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZW0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZW0"/>
    <dbReference type="WBParaSite" id="TTAC_0000636301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000636301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000636301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16955at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05427">
        <property type="entry name" value="FIBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000636301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43726" checksum="2EBB3A9632851ADC" modified="2016-01-20" version="1">MGAELFDVFCSIPFVFNEDVFEFWIDGLAVEETTRKLQSQSDVEAFGLSSDLLVTFVADQYAQFSLLESLLTRPDVFLTSSFTCFGDWKLRRKLIERYYSLEDALCRELLGSKLSARFRRDLADIAERCGLRLRSCRRQYENLRRVARLVEDTPGHLCDIIRRSFALPPALAELYAAMIFLSVNRFETSKRCFSGATFADFTYCAEQLMTYWTVTDNLENKLDSPVDLELDFGFCTELKVLKLLTEKQTYFERHKSLVIRQVSSTVSDSCLNWIEFNFKTLSKAITTIATGLSHAKEVRDLFLDIMEKVIEIVVSAQWTYQEFSSFLTAFDETLRILPPAKSSSFQRSWVRFFAPFKSICLRLYPLPVNSSITVTTATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X011</accession>
    <name>A0A0R3X011_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X011"/>
    <dbReference type="WBParaSite" id="TTAC_0000642901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000642901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000642901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000642901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9239" checksum="D520D34E6849259E" modified="2016-01-20" version="1">MEVTLEAEVASVCGNGGEREGDVDEGDVDEGGGDIGGCGWEEGGFCEMDRSETKGVEERRRSNKCMPPSPPPPPPPSFYNESWKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X084</accession>
    <name>A0A0R3X084_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS6499</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020306">
        <property type="protein sequence ID" value="VDM30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X084"/>
    <dbReference type="STRING" id="6205.A0A0R3X084"/>
    <dbReference type="WBParaSite" id="TTAC_0000651401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000651401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000651401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000651401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37175" checksum="399ABE2EC25122E1" modified="2016-01-20" version="1">MSKIEDFPIPKNDVILRVCKGLTVPYAPVWIMRQAGRYLPEFQAVRKEHDFFEICRTPDLVCEVTLQPIRRFNLDAAIIFSDILVIPQALGMEVVMDPGVGPQLPSCLNTPKDLARLDWSADVKSHLDYFYEAVRLTRHRLEGCVPLIGFAGGPWTIMTYMIEGGGSKTFLKSKRWLYAYPKPSHRLLGLLTRTITDHLVHQVLAGAQLLQASSVSLAWSLSRYYRQGKCIFESHAGVLSSHLFNVFVLPHLRQIYAGVRSRLQNLHGFSADECPPIIMFALGGYYALEEIASVGFEVIGLDWTTDPKWARQVIGPSITLQVSWATFPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0F7</accession>
    <name>A0A0R3X0F7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS6599</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0F7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0F7"/>
    <dbReference type="WBParaSite" id="TTAC_0000661401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000661401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000661401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="385"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="845"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="924"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000661401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="958" mass="106326" checksum="8B5093409F8F2386" modified="2016-06-08" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0L4</accession>
    <name>A0A0R3X0L4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6667</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020314">
        <property type="protein sequence ID" value="VDM30910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X0L4"/>
    <dbReference type="WBParaSite" id="TTAC_0000668201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000668201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000668201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1870062at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040214">
        <property type="entry name" value="BRD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056522">
        <property type="entry name" value="KIAA2026_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095:SF3">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23450">
        <property type="entry name" value="KIAA2026_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="754"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="812"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000668201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1357" mass="150587" checksum="BE374395230381A2" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0M5</accession>
    <name>A0A0R3X0M5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Laminin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6683</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020315">
        <property type="protein sequence ID" value="VDM30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0M5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0M5"/>
    <dbReference type="WBParaSite" id="TTAC_0000669801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000669801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000669801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133183" evidence="4">
        <location>
            <begin position="18"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000669801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49133" checksum="286BFD70CAE903C4" modified="2016-01-20" version="1">MLHALIALFSLTSAVWTAYTPTPISSTSDGRQASFKVIYESPTSVCYAENRAYLCTPPLTNIAEGVPVVATSTCGQDGRPEKICRSWTPLSSQQRRTTCEICDPRKTATSRGAERLTDRHISSNQTCWVSGRVPPGGTVNLTLSLGKRFEIFYISLQPCSPLPDSIALYKSSDFGRTWKPWQYFSTDCYRAFGLPTSNEYSAQISSANIQEVLCVALKSPTKYNSQGQASNVIAFSTTIGRSTLQSWSPALIDWMTMTDLQISLTRFSSRRKSVGGERGSGDPTVVLHRRDRSSGLRRVSQKAPVFRLGGGGGSNGRFIRADEERMQADGSSSNSSTRWFHDKKKKKDEETEGEKVEEEDAVYFAFSDITVGGRCKCNGHANRCVRDRIVEKNSAGEEVISWGPLRCDCQHNTVGADCERCAPGYLDRPWARATNEDANVCKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0P5</accession>
    <name>A0A0R3X0P5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR_substrate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6707</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0P5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0P5"/>
    <dbReference type="WBParaSite" id="TTAC_0000672201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000672201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000672201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268908at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000672201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14989" checksum="B3A3F6C0BE9D13A1" modified="2016-01-20" version="1">MEFKLTLRRGYKKAICFHISCPDFIAYASRIGRRNVLKLYLLEEESLAVPEWLTLAEGVRPHPLTEKVVVPGTLNRLVGMLSVAKEELPDCPLYFQSDRLCATLRTPVPKIALIRSAFLYAFSSFRCEQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0U6</accession>
    <name>A0A0R3X0U6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6767</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0U6"/>
    <dbReference type="WBParaSite" id="TTAC_0000678201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000678201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000678201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000678201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17797" checksum="50CE2D7C155A5D0D" modified="2016-01-20" version="1">MSGAGVEAILLALHLPRGLYFLLLFILYLRLVLLTLLLAAATTMSWQLEGGATSVWCQCGVSESMSVLLTPMMVGLAWASPTVSLRPRCDMERTTLIHLVHRSPLNFLPQFPIQRLISRPLLLRRPLFLSSSSLPTTALRCVIHTSSRCPRAASSYFCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0V6</accession>
    <name>A0A0R3X0V6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6777</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020322">
        <property type="protein sequence ID" value="VDM31043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0V6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0V6"/>
    <dbReference type="WBParaSite" id="TTAC_0000679201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000679201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000679201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000679201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21753" checksum="3B6D0716F8D44576" modified="2016-01-20" version="1">MPYEPVLAPAGVTSDSTSSVSEDSGFRHYLRKVSSLGTPAQVTSTIFIIPRNEVVNDQVFSKSYDSAEVQEWKHPRWREYTPVDRTSLTDPSSTTNMATATLTTSTMITTESGFQDVGLSSSTISSSIESPRSTSIEHVEDEPEEIARHPRHSTTYQFRSQNLQPRSGQVITSWFQKIFRRKESEGLKDPQNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X153</accession>
    <name>A0A0R3X153_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6887</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020329">
        <property type="protein sequence ID" value="VDM31167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X153"/>
    <dbReference type="STRING" id="6205.A0A0R3X153"/>
    <dbReference type="WBParaSite" id="TTAC_0000690201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000690201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000690201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035498">
        <property type="term" value="P:carnosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000690201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42941" checksum="7EFE12FA4AA5AD60" modified="2016-01-20" version="1">MDVDDLERKHFMKTLAVFKYYRSYALKKVSEQTEIYEKLSERHKTLIPDFPVALEKIKKCVENNAFFISQILRNAKPDIFEGDHFLTHQNDAIQNFVQSDGSNSRSDFAITSSDLDKINSVLKQFVRDWSNVGAEERKQSYEPVLDEIKKLYWSSDRQLSDIRILVPGAGLGRLAWELANCGFSCQGNEWSLYMLLPAYFILNTCKKVGEYTLHPWVTQFCNNMTRENQTTAVTVPDVLPTDIPAGVQFSMVAGDFVEVYSEPGSWDCVATVYFIDTAHNILDYLDTIWKILVPGGYWINFGPLLYHFADVPGQDSIELSYEELRKAIQLMGFQFVKEEVKIPSTFTQDPNSMLHYHYKCVLNVLRKPLDAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1L4</accession>
    <name>A0A0R3X1L4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7092</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020345">
        <property type="protein sequence ID" value="VDM31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1L4"/>
    <dbReference type="STRING" id="6205.A0A0R3X1L4"/>
    <dbReference type="WBParaSite" id="TTAC_0000710701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000710701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000710701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.50:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="6">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000710701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="37414" checksum="CD299B775EB30C14" modified="2016-01-20" version="1">MSLRERDVLYRLIISQLFHDGYQAIAINLMNEVTPSVSCGPSARLLKLVKLGLSIADDEQDRSVALEGDNIPPGTGIDLEIESESSTMAPEAALYETCYVTAHKAACRAAAFNSTGALAFSKAFIVGMFRYIFSLSSIGQLIATGSHDSSIKILDVERMLAKGNSGPEHSAQETPQQQMEAHPVIRTLYDHTAEVTCVDFHPDASQQILVSGSKDYTIKFFDFSNPSVKKAQRSIPEASPIKTLHFHPSGNYLLVGTHHKTLRIYSVNTCQCFVSAVPEDQHNGAVTMARWAPNANYFVTSSVDGSFKIWDGVSGRCVSTFEAAHDGLPVCSAVFSRNSKIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1L6</accession>
    <name>A0A0R3X1L6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">MANSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7095</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020345">
        <property type="protein sequence ID" value="VDM31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1L6"/>
    <dbReference type="WBParaSite" id="TTAC_0000711001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000711001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000711001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037294at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011106">
        <property type="entry name" value="MANSC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876:SF1">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07502">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00765">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133116" evidence="10">
        <location>
            <begin position="23"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MANSC" evidence="11">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000711001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54926" checksum="46E117C051D816BC" modified="2016-01-20" version="1">MGSVSMFSISIQLFALFITVFSRKCDKDFDIHINTIILTHVSDANGAPFIRKPPAHSLVECIEYCCDTSECTVGVFGPKEDDKCFLFNCFERNMCNFTSESGYTVFMQRTLSHELSNVPKFAMLSSGSFRTYCGPKNPCVIANSICDSGQCVCKPGFIEKRRKCVPSICSKPELEFQCDDATTCIAVYDVCNGIVECPDASDESFCEKEITRASSIRKVGPPRFSGTHVLNARTLLPHDGAEHSLSEVVEPFKMRSVRPPHFVHDNPVRRIYQDKKEYKLPGYRAPSLETNVPSLMVSEAQEKSIFPDDIVNTFLERPERLRSQFADDDTSVNNHWRKIGRHTLFRDFGEKDGIHSVPYHRWPDLDREHKVLRHTVRPFPEHSGNLYFQRNVAHFSAKSSAASAIGFYSQSGYQWHTAAILLAIGLGLTSCLFGLLVGRCRQRGRFNQGGPRSKAVATSHLRQRIMRTRGLSNNDLERSGLLSKLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X205</accession>
    <name>A0A0R3X205_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7268</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X205"/>
    <dbReference type="STRING" id="6205.A0A0R3X205"/>
    <dbReference type="WBParaSite" id="TTAC_0000728301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000728301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000728301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="7">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000728301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29989" checksum="58C4E78D41601C0A" modified="2016-01-20" version="1">ETKESEEVPVTQVTETTVSGTVADSESSKDGVKSEKPTEKLKLAVKKKVLQRLRYLRMKKICIEHAQKHLIEYKRAAKREINLMRSAQRDGNFYVPAEPKLAFVVRIRGINGIHPKPRKTLQLMRLLQINNGVFVRLNKATLNMLRLIDPYIAWGYPSLKTVRRLIYKRGFCKVAGQRLPLTNERIQHRLGRFGIVCVEDLVHEIYTVGPKFKEVSSFLWRFKLNNPTGGFRKKGRHFVEGGDFGNRENYINRLLKTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2D5</accession>
    <name>A0A0R3X2D5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7431</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2D5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2D5"/>
    <dbReference type="WBParaSite" id="TTAC_0000744601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000744601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000744601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="805"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000744601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120583" checksum="C0C6BF39FA05430C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N6</accession>
    <name>A0A0R3X2N6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7549</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020382">
        <property type="protein sequence ID" value="VDM31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N6"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N6"/>
    <dbReference type="WBParaSite" id="TTAC_0000756401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000756401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000756401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="424"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000756401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57931" checksum="5D86749142BA0920" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2V9</accession>
    <name>A0A0R3X2V9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">DNA repair protein REV1</fullName>
            <ecNumber evidence="13">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS7634</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01020389">
        <property type="protein sequence ID" value="VDM32049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2V9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2V9"/>
    <dbReference type="WBParaSite" id="TTAC_0000764901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000764901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000764901"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <sequence length="1019" mass="112606" checksum="D7D6AB6B202356B3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X383</accession>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2016-04" db="UniProtKB">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="384" mass="44338" checksum="771B56C4D39FA202" modified="2016-06-08" version="2">MTDESVGTIKVKFNGQLLQLDGFSRESPIKCLKEKLYQLTNVPPKNQKLLGLVVEKGQTLSDELPLKHLILKPTTKLMLMGSTDEERNKVIELSNAEPPDVIDDYDFTEEDLAVFMRPENLEKLAKRCNTYKFVKIAEFRPGKRLLVLDIDYTIFDHLTPAESVKHLMRPYLIPFLTRAYEFYDIAIWSATSMTWILAKISQMELISQTIVNRVRQRRVDVDNEDSNSVPNLGADLDDTDRPFKICLLIDSGAMITVNLPNHGVKGVKPLAVIWRKFPQFGPHNTIMFDDVRRNFAMNPGSGLRIHSYRDANVNYAEDKELMHLADYLELIARRETDFQRLNHDKWSHYVGKHQRYLSNHQKRSSDEATEENCEGQDQKRPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3K6</accession>
    <name>A0A0R3X3K6_HYDTA</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7921</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020421">
        <property type="protein sequence ID" value="VDM32396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3K6"/>
    <dbReference type="WBParaSite" id="TTAC_0000793601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000793601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000793601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270390at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000793601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19359" checksum="F5B1EAD87C6327A2" modified="2016-01-20" version="1">MTKVFVDRVYGPQPLLLRLPLPTKKLKDIKVDDSSIFHCHQRSPESPSFESIDRHLAPSSPFYSVTLVREYFGFFLISGSVILILLNLRTLLELCTLRNLTRSLRVLHRRICGRRVQIQRNSGLEVGGLNVVDDTCDFEAPPARAVVVETVHTSLTYRLVSQCLRQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X452</accession>
    <name>A0A0R3X452_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8155</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020456">
        <property type="protein sequence ID" value="VDM32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X452"/>
    <dbReference type="WBParaSite" id="TTAC_0000817001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000817001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000817001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="706"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000817001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1568" mass="171258" checksum="661F9AE2B0A22366" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I6</accession>
    <name>A0A0R3X4I6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS8311</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020482">
        <property type="protein sequence ID" value="VDM32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I6"/>
    <dbReference type="STRING" id="6205.A0A0R3X4I6"/>
    <dbReference type="WBParaSite" id="TTAC_0000832601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000832601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000832601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="13">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000832601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="45078" checksum="A6E885D45A93390D" modified="2016-01-20" version="1">MSSSFSYAGSDRPTSVVVAEPATRPTSHRNVSSTVVERHFGGVSSNPQRPAASAALFDFDSTGADSGSNGSSSGGGGGGVGAVGGISHPASASVTPITATPVLPNGPERPPPTGAGGDPPAPTNSMDLVSLFECPVCMDFALPPILQCQSGHIVCASCRTKLSSCPTCRGNLENIRNLAMEKLAASILFPCKYALTGCAETFHYTVKAEHESVCEHRPYSCPCPGASCKWLGQLDQVMPHLLQSHKTITTLQGNTSDPQLSMSNNRFAVTLSLPPDLLHYIGEDIVFLATDITLPGAVDWVMMQSCFGHYFMLVLEKQERVSPDQFFFALVLLIGTKKQADQFVYKLDLTASTRRLTWEATPRSIHDGVQAAIAVSDCLVFDSNVAQLFADNGSLGINVTISRARGNGSGGGGTNTSGTGSASGGSASAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4N1</accession>
    <name>A0A0R3X4N1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PBPe domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8363</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020490">
        <property type="protein sequence ID" value="VDM32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4N1"/>
    <dbReference type="STRING" id="6205.A0A0R3X4N1"/>
    <dbReference type="WBParaSite" id="TTAC_0000837801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000837801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000837801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273151at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="334"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000837801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="633" mass="69572" checksum="D1CB823F6706CA40" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5B4</accession>
    <name>A0A0R3X5B4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020547">
        <property type="protein sequence ID" value="VDM33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5B4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5B4"/>
    <dbReference type="WBParaSite" id="TTAC_0000864201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000864201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000864201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000864201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15212" checksum="A88FCCC8D4F383DA" modified="2016-01-20" version="1">MKRHKASGKKKVAIDLEIAEQLKVVKWPTIVDLLPIALLRAAFSFILGIPNLLGSLKCILVASFEKARREREEQRVLYSSSELVRKAYVVSPGESRSLESVSMIFQDFLNVHSVPQCVEVEEEEVRRSAKRVCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5E8</accession>
    <name>A0A0R3X5E8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Malectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS8672</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020560">
        <property type="protein sequence ID" value="VDM33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5E8"/>
    <dbReference type="STRING" id="6205.A0A0R3X5E8"/>
    <dbReference type="WBParaSite" id="TTAC_0000868701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000868701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000868701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
        <property type="entry name" value="MALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133236" evidence="12">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="13">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000868701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31479" checksum="D02E571693A2AD70" modified="2016-01-20" version="1">MIWAVVRVVFCLVVRGNLAAKLNPVFAVNCGGDEHIDSNGVLYFADFNDRGIASGHGLNLVMHRAPESDAVLYQTERYDTSSFFYEFPIPADGKYVLHLKFSEVWFQYPNGKVFSVELNGLRIIRDLDIFRKVGFSVAHDENIPLTIKDGSILVGDASAKLSNDGKLRITFVKGNHDNPKVNAIALFKNTIEDIPKLPPLDYLEEGDGFEPQDPLASSTMSPLHGNAKGDVDFSQRPRRLPMPSSLEKPPAPDPYASTDYSVYVLPILISVAAFLPLVFCLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X602</accession>
    <name>A0A0R3X602_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8905</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020624">
        <property type="protein sequence ID" value="VDM33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X602"/>
    <dbReference type="WBParaSite" id="TTAC_0000892001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000892001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000892001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000892001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9836" checksum="27341810760628BE" modified="2016-01-20" version="1">MEQKVMPEAVEGSVGLLSCSDDRGGEHNVPLGASVPHPPDTCLKADQRHASSVQMVPIHSLLLLLLLLTLLTLESKMHSQITTISHCANSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6A5</accession>
    <name>A0A0R3X6A5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">cAMP-regulated phosphoprotein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9015</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020655">
        <property type="protein sequence ID" value="VDM33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6A5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6A5"/>
    <dbReference type="WBParaSite" id="TTAC_0000903001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000903001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000903001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 4" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000903001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17687" checksum="0112DAD4742C8164" modified="2016-01-20" version="1">MEGGGCPVTVHEKTPEQIAEEKLRAKYPNLVAQGPSILQKRLNRNVKYFDSGDYNMAKARCNNSQKAGMLKANPTSSSTIPEVPADVIAAQQTGDTIPTPENVPAVRKKAVELQHELQHQSHLATTVTSVTSGAVTTTHSFSSSRDPPAVSIVESGLAPTNSPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6A9</accession>
    <name>A0A0R3X6A9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020656">
        <property type="protein sequence ID" value="VDM33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6A9"/>
    <dbReference type="WBParaSite" id="TTAC_0000903501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000903501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000903501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000903501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9821" checksum="C5F3F46C6E4443B3" modified="2016-01-20" version="1">MSLEQCKCLPRSYAPVAVVGSPAPTPEEEDMFICPTDASRVDPTTETEGHWSPAASSPFSSSRFRRHACLGFMFLSRTCCSSLVMRVTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6G3</accession>
    <name>A0A0R3X6G3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9079</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020674">
        <property type="protein sequence ID" value="VDM33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6G3"/>
    <dbReference type="WBParaSite" id="TTAC_0000909401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000909401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000909401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261199at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000909401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1033" mass="110791" checksum="71096E3D67DFD926" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6T2</accession>
    <name>A0A0R3X6T2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020721">
        <property type="protein sequence ID" value="VDM33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6T2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6T2"/>
    <dbReference type="WBParaSite" id="TTAC_0000923301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000923301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000923301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000923301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11235" checksum="939012A0240945DC" modified="2016-01-20" version="1">MKIAERIDYLRKVNLSRVAELEYMRDYELKEFSANTKHLTRLLDLLPMLNHQRCFYSGKHIEGSRRRKKRFINNSTASGESYNNEIISSSYTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X709</accession>
    <name>A0A0R3X709_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex subunit 13 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020754">
        <property type="protein sequence ID" value="VDM34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X709"/>
    <dbReference type="STRING" id="6205.A0A0R3X709"/>
    <dbReference type="WBParaSite" id="TTAC_0000932001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="31938" checksum="69C0BB133B07C7E8" modified="2016-01-20" version="1">MPQPLMVERLAWEPGPLIKATDLNSLVDWTRSRRKGRLTPTLMAPKEVWRLLYLTQPLNTSAASAAGEVKLGHLDIAWRTTMGETGHLLTFPCMSNIPHYSDVSMNVVKLPAQVVVEDPFQMVCEITNRSFALIFSTISTTTYFCRPLSLFSSRVLELMLSRPETSATTATAGGYETTSDTTTTTGAATAAVAVTAAAFPAFIWTGVTYQRLPSLAPATSTQLTLEFVPVMTGLQGWVIVGVLPNILPFYRSDLVWSGPLKEVPPFELKEISTEGCFTFSNLGWVLVTSAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X769</accession>
    <name>A0A0R3X769_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9373</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2. Interacts with TASOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020786">
        <property type="protein sequence ID" value="VDM34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X769"/>
    <dbReference type="STRING" id="6205.A0A0R3X769"/>
    <dbReference type="WBParaSite" id="TTAC_0000938801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000938801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000938801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="75"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000938801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30641" checksum="70F5C730BD4B891D" modified="2016-01-20" version="1">MEDLVRKFQCLSQEWNKKNHDLAVCQEKLENLTLDLTQFCYMPNRETFASKRELLIARDTLEIGAILSLEKRDMAAFERYMSQLKCYYCDYKVNLPDSPYKYELFGLNLLRLLAQGRLAEFHTEVERLSSEEINMNAYIKHPLSMEQYLMEGSFHKVFLSKGNVPSERYNYFIDILLDATRDEVASCIEAAYEELSVEEAAKALFFTKPEQMKAYAKQRHWTQVNGRYIFAKSNKQTENALPATDLAKILLYYTHELEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7W1</accession>
    <name>A0A0R3X7W1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibrillar collagen NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9621</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020933">
        <property type="protein sequence ID" value="VDM34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7W1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7W1"/>
    <dbReference type="WBParaSite" id="TTAC_0000963601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000963601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000963601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="5">
        <location>
            <begin position="712"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="679"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000963601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="926" mass="90383" checksum="86C60DF78E510CB3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X844</accession>
    <name>A0A0R3X844_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9704</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020992">
        <property type="protein sequence ID" value="VDM34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X844"/>
    <dbReference type="STRING" id="6205.A0A0R3X844"/>
    <dbReference type="WBParaSite" id="TTAC_0000971901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000971901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000971901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DDHD" evidence="4">
        <location>
            <begin position="154"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000971901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71322" checksum="DD86227FAD713EBA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X848</accession>
    <name>A0A0R3X848_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING finger protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9708</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020995">
        <property type="protein sequence ID" value="VDM34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X848"/>
    <dbReference type="STRING" id="6205.A0A0R3X848"/>
    <dbReference type="WBParaSite" id="TTAC_0000972301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000972301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000972301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000972301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44502" checksum="75615C846737FF65" modified="2016-01-20" version="1">MTYLRVFYSSAVGEIELEDVGWSEVGEVAIHSPTLSLCGRCYQRPFLPRIGPCGHIYCLVCIWVRIAFNHDERVETCPTCGRSLKVTDLKRVSIFKSYIPKVGDVMKFRLLPKDTKCVNSYVLDIWTAKYCAHLVKTKRRSYRYFIRKDIALMKKYMSKWKDAKNSTITRMVAGEIFASLLQEQERLNYGAESIGPFTKRYILHLHSYTVFLHAFNRACLSLAFKKIGLPKMVSGKVIFIECHTMDLNIREMIPDLRHVPLGHTFYLVLLEFEASTFSDFHDLQPIFGGMLLDFVRPSFNLKVAVGSIINSFVSLNMRHTCVYFVDELFSITPAEHRSFYKDHDGDIKNLEESNNWRSITLPSGSKAFFADSLLRRYLQEGLSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8C2</accession>
    <name>A0A0R3X8C2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-type Cu(+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9782</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021045">
        <property type="protein sequence ID" value="VDM34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8C2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8C2"/>
    <dbReference type="WBParaSite" id="TTAC_0000979701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000979701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000979701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060003">
        <property type="term" value="P:copper ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000979701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="643" mass="69659" checksum="0022A293ACDAFE74" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8X3</accession>
    <name>A0A0R3X8X3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9983</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 11">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021214">
        <property type="protein sequence ID" value="VDM34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8X3"/>
    <dbReference type="STRING" id="6205.A0A0R3X8X3"/>
    <dbReference type="WBParaSite" id="TTAC_0000999801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000999801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000999801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000100">
        <property type="entry name" value="Glutamate dehydrogenase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="233"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000999801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57686" checksum="2EEC954D3A6B7F8D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9J2</accession>
    <name>A0A0R3X9J2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10202</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021421">
        <property type="protein sequence ID" value="VDM35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9J2"/>
    <dbReference type="STRING" id="6205.A0A0R3X9J2"/>
    <dbReference type="WBParaSite" id="TTAC_0001021701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001021701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001021701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000014">
        <property type="entry name" value="dynactin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001021701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="21933" checksum="B3CC048071B98EFB" modified="2016-01-20" version="1">MELQDIFYDGSRYVETASGNKVSRNASICGSQNIVLSGKTIIMSNCIIRGDLANIRIGRRCVISKGAVIRPPFKKFSKGVAFFPLQIGDHVFVGEGAVVNAAQVGSCVYIGRNCVVGRRCVLKDACALLDNTVLAPETIVPPFSVFGGSPGRCVAELPECTPELMADLTRSYYDHFLSKTTSVVTPAPSSNRRVSAATTGAKRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA01</accession>
    <name>A0A0R3XA01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10361</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021592">
        <property type="protein sequence ID" value="VDM35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA01"/>
    <dbReference type="WBParaSite" id="TTAC_0001037801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001037801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001037801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6239681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001037801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12315" checksum="7EE66E4244761D95" modified="2016-01-20" version="1">MKEAVPVGNGCPVTAPWPCQQYSFCLSFAFVCDGEIDCPDGYDENPRLCVARVDGGRKAFGREIDRFQVLPLGGGRQSQNRECDVVGPRLWPDGHSPIQPPWQPRNTSTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA64</accession>
    <name>A0A0R3XA64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10424</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021684">
        <property type="protein sequence ID" value="VDM35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA64"/>
    <dbReference type="STRING" id="6205.A0A0R3XA64"/>
    <dbReference type="WBParaSite" id="TTAC_0001044101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001044101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001044101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6233530at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001044101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19825" checksum="C1D47A76D778CDE8" modified="2016-01-20" version="1">MVKSGLFVLENFRCKPSDEFLVVDAESHSDWMLVTSVQTRQSGYLPKFCLEKVYPDIIERLSFFHEDSTSLEQQELLKRNGPFSYLLRLCDSNPGLYTLLVYDGTRILKYKIATSIVWWATPQPHGNAANNDDSGKSAPTTTTSTAVSSDDVIEGGKCAEPSATDGASNSLSFQPFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAF3</accession>
    <name>A0A0R3XAF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10513</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021787">
        <property type="protein sequence ID" value="VDM35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAF3"/>
    <dbReference type="WBParaSite" id="TTAC_0001053001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001053001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001053001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001053001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10416" checksum="830E3523DFB49ED0" modified="2016-01-20" version="1">MATTDAATERAAVAKSMDEGADALGAVITEVEVEDDVSVELFLEYILCAHTPVHIMLSALVWGAERQNEECREGKIIDGRSNSSHNIDVQSKSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAH5</accession>
    <name>A0A0R3XAH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydro-rel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021813">
        <property type="protein sequence ID" value="VDM35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAH5"/>
    <dbReference type="STRING" id="6205.A0A0R3XAH5"/>
    <dbReference type="WBParaSite" id="TTAC_0001055201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001055201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001055201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001055201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26361" checksum="DB7B26B801598FDA" modified="2016-01-20" version="1">MHKIYTSQREHPPLSIYADFAVDAFVENSMDDQAPYIAAEEHVILSSGKSYALFSEMKSSENPWIQKAYQKIVGGGWGNESHIIEASCKIPAQLTGLLPQKGQLAIGADADLVLWPEGDCSKPIFTIVGGRIAVQYGRLRETTPRDQEEGKSVKAGLIRSGQTPCSMLAVSHEKIGEIGKTLLPMLSPPQPLTPVVGQTTKTWENAKPGPSGDAALAGLPSREIRSIASLYKRESLASTFKLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAR0</accession>
    <name>A0A0R3XAR0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021949">
        <property type="protein sequence ID" value="VDM35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAR0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAR0"/>
    <dbReference type="WBParaSite" id="TTAC_0001063701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001063701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001063701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266673at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001063701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31412" checksum="2F9F2B08BA22265E" modified="2016-01-20" version="1">MATIVFRYLLFHQLHRDFLSGRLIAPHEDLIRLAAFFIQVALGDASEVTASTPNPQSSFDSTNTESPTYLSNYRALHNTSSKKNELEILEEHRKLEGVLPSEAAAEAIRIALRQLSYGLEPFKVLPTKRRNSRPVHIGLTHEGVAEFFGSKRAHLFKWAEIDQFFYSGKNFIPAHEITEYKCESRAIASELWSWALERKLFFTLDITNAIPTPPFCTLFSNKFCMFDFGHFLFATNFGGFEEIGLLCRLEKSSLVKPITTKYKLFSRRHTFTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAT8</accession>
    <name>A0A0R3XAT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Essential MCU regulator, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10648</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021987">
        <property type="protein sequence ID" value="VDM35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAT8"/>
    <dbReference type="STRING" id="6205.A0A0R3XAT8"/>
    <dbReference type="WBParaSite" id="TTAC_0001066501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001066501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001066501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283877at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001066501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8927" checksum="0B31B0A64EA22A91" modified="2016-01-20" version="1">MAKQKSSVMTSAVPPFLPSSLSILTKARDFKPEGHTHDSGKITPGYALFIGVAGVLILLLSTVLLTVDKRVDEIVYREKITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAZ2</accession>
    <name>A0A0R3XAZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10702</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022080">
        <property type="protein sequence ID" value="VDM35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3XAZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001071901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001071901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001071901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001071901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36683" checksum="A0382B56E4C4CB87" modified="2016-01-20" version="1">MLYERNTVPDNWVAADFLMRLQRNVNLQVFDLSTIMLYSGLVFQQLCRYGFHFFSHFKSICIFVTFFVFLLWERVTPLYLSIVILLVSVFTFMLWFFWSLSSDERNIKVRKSDRSRFLTYFCCDLSKPDHVLVSTPLRTVLIILVFSSALAPVLHSLLDTVSTDTIYAMTAIFLFLNFVSLPYASGMRPSRGDGTADSNIVSVATGFLASLCMASRLPGPKETLLLIISATLVFATWPTIRHRIQVLKGVKSRLSFTLGMGVTAALSLLPFFLDDGIESVYKGLIAVATLLSAVLINFALPLIFYEMQSTKSNINGPWDEAVIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB85</accession>
    <name>A0A0R3XB85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10795</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022251">
        <property type="protein sequence ID" value="VDM35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB85"/>
    <dbReference type="STRING" id="6205.A0A0R3XB85"/>
    <dbReference type="WBParaSite" id="TTAC_0001081201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001081201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001081201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001081201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14619" checksum="F1C552D8D9CAE80D" modified="2016-01-20" version="1">MYMFSILPHPPISKIWFAKARAPTFDYFGGTIPLILQTSLQRGPLAYKVPGMIDLMLRRLRRREMGTKAPFDSSSERITMTGKRRSEGPGPHDYNPKPESECKHENLEKINTSRKISDFRTPTDHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBD6</accession>
    <name>A0A0R3XBD6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS10845</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022352">
        <property type="protein sequence ID" value="VDM35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBD6"/>
    <dbReference type="STRING" id="6205.A0A0R3XBD6"/>
    <dbReference type="WBParaSite" id="TTAC_0001086301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001086301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001086301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283643at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001086301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7506" checksum="B7E61CA70769F9EF" modified="2016-01-20" version="1">MTEMLLKMYGLGFRLYFQSSFNIFDCVVIIGSLFEILLALVQPDTSFGISVLRALRLLRIFKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBM7</accession>
    <name>A0A0R3XBM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022571">
        <property type="protein sequence ID" value="VDM35917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBM7"/>
    <dbReference type="WBParaSite" id="TTAC_0001095401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001095401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001095401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001095401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11191" checksum="E867317F093C468D" modified="2016-01-20" version="1">MVEIMVTPPLSVTQEEEVEEEEDVGGVKTLHENEEEEEEEKEETKEKVNKEDRQCMKSSACGGAHLCLLAEMRAPDVAMVGSVCVWVVHLEVNKKMKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBS3</accession>
    <name>A0A0R3XBS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin-like 120 kDa protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10983</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022662">
        <property type="protein sequence ID" value="VDM35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBS3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBS3"/>
    <dbReference type="WBParaSite" id="TTAC_0001100001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001100001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001100001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF67">
        <property type="entry name" value="DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="2">
        <location>
            <begin position="101"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001100001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45195" checksum="1C0EF9ED09A55BAE" modified="2016-01-20" version="1">MSVSKHTNAEEVDHEQSRTSDGKNKYFSHIFFVEPKVPVEELKKYQKALGDLKTENRNLRKQLLLKYQKSAQPDRIKKTLIDMYSEVLDELSNLDTDYNIQDHLPRVVVVGDQSSGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPYHVAAFRDSPKEYDLTNETELASLRNEIELRMQGLVADGKTISTEVISLSVKGPGLQRMVLVDLPGIISTQTTGMELGARESIRKLVKQYMDNPNAIILYGSIDAERSNVTDLVASVDPQGKRTIFVLTKVDLAEANLYNPNRIREILEGRLFPMKALGYYAVVTGKGSKDESIESIKEYEAEFFKKSRLFREGALKLAQMTTENMSKAVSERFWKMVKDSVEQEADTYRGNLYWLSTTSCYFHSIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBX6</accession>
    <name>A0A0R3XBX6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS11036</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01022779">
        <property type="protein sequence ID" value="VDM36016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBX6"/>
    <dbReference type="STRING" id="6205.A0A0R3XBX6"/>
    <dbReference type="WBParaSite" id="TTAC_0001105301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001105301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001105301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="10">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM36016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001105301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="861" mass="96790" checksum="03F7416C304C8D08" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD84</accession>
    <name>A0A0R3XD84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11494</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024489">
        <property type="protein sequence ID" value="VDM36723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD84"/>
    <dbReference type="STRING" id="6205.A0A0R3XD84"/>
    <dbReference type="WBParaSite" id="TTAC_0001151101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001151101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001151101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001151101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15154" checksum="62118D4CB7D15BEF" modified="2016-01-20" version="1">MARSSTRDSGAESALALPPPPSHCTPSSKECRMAALAYAPCLPAADRLLTSSSMDTAKNIQSNFSSRRPSVLDMVRLFKKSPSVTTPPDLNAIAGEQLQSEGEDPMNEDFLSPDSISWNMEFVVQNPNIMANYNDVIFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDB9</accession>
    <name>A0A0R3XDB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11529</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024694">
        <property type="protein sequence ID" value="VDM36849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDB9"/>
    <dbReference type="STRING" id="6205.A0A0R3XDB9"/>
    <dbReference type="WBParaSite" id="TTAC_0001154601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001154601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001154601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001154601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="31000" checksum="DF21639E973CDC4D" modified="2016-01-20" version="1">MVSFVPSLRATVNSRFVRGPAVFDDEEQWFNQDDEDDDEAEISTQTQPHGQPSMTLESIPSRYFTTSNSPPAPSSPSGSPKALHHSPGHSTATATTAPSFSLLIPSSSSSSASDSSPGSLINRRVGPTSYPPISIHIRSTHLGALSGMDSEDDANVSSPPRNALKRLSGRSEDDDAAASSGDGSSGGDESSDGDEDVPTIKHSRRRSLVEEHRDSNNNNNSSGTNLGTVPGKIGEVEIVSKPADTAKSPMVGLVDYSDEESDEEESSLSPTDTKPPPTNLGATEEPRAVKSTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDL0</accession>
    <name>A0A158RDL0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS867</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000115">
        <property type="protein sequence ID" value="VDM17105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDL0"/>
    <dbReference type="WBParaSite" id="TTAC_0000086601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000086601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000086601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF55">
        <property type="entry name" value="BESTROPHIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000086601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="61685" checksum="106ED21EC7FE4DC2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDR9</accession>
    <name>A0A158RDR9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copine domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1400</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000296">
        <property type="protein sequence ID" value="VDM17936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDR9"/>
    <dbReference type="STRING" id="6205.A0A158RDR9"/>
    <dbReference type="WBParaSite" id="TTAC_0000141301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000141301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000141301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copine C-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000141301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24077" checksum="60A06A5ACAEB4BA4" modified="2016-06-08" version="1">MFYAGHLSALTTVSFSLLPSPAHHTPPSLLETNGPTLLFSPPNIHTLAQQTDDGSQYYILLILTDGIICDMPQTKAAVVNASRLPVSIIIVGIGAADFSAMEELDGDEIRLTSRGRRADRDIVQFVPFDDFVNLTSVMDTKRQLARAVLAEIPDQLISYMRSRGYKPKNLGRKQSQMSRFSKTATNSSKIETDSSNSYRRSDYCNLQSSSPSAPPHPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDZ2</accession>
    <name>A0A158RDZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fmp27_GFWDK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6337</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000635201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000635201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000635201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="238"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1790"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000635201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1809" mass="201638" checksum="89076CEBBCF2AAB8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REV3</accession>
    <name>A0A158REV3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA methyltransferase 1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8128</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020452">
        <property type="protein sequence ID" value="VDM32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REV3"/>
    <dbReference type="STRING" id="6205.A0A158REV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000814301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000814301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000814301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="8">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="8">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000814301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56340" checksum="0286C26D4F75D06F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RFB2</accession>
    <name>A0A158RFB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9389</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020793">
        <property type="protein sequence ID" value="VDM34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RFB2"/>
    <dbReference type="STRING" id="6205.A0A158RFB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000940401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000940401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000940401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6019271at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000940401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13828" checksum="9B44617EC5BD3965" modified="2016-06-08" version="1">MTDPATSLNRQGTKHLLNRIYTTIAPLCIEKSVASNDTSAQLVTTQASEILLGWLTYILDPTNCGRLTVSGLKVALSTLATGRPIDKFTLPDCNTILVQVHISPLLDETPSPVSRFGRREGQYQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E5M9</accession>
    <name>A0A3P7E5M9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000290">
        <property type="protein sequence ID" value="VDM17910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E5M9"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="206"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="413"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="678"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="894" mass="96883" checksum="07B32BF0B906560B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EDD4</accession>
    <name>A0A3P7EDD4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galactosyltransferase-associated protein kinase p58/GTA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS2619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01001291">
        <property type="protein sequence ID" value="VDM20691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EDD4"/>
    <dbReference type="OrthoDB" id="647at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000124">
        <property type="entry name" value="cyclin-dependent kinase 11B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="363"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="656"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM20691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="740" mass="82797" checksum="7CCE4B1459A213E1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ER72</accession>
    <name>A0A3P7ER72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003251">
        <property type="protein sequence ID" value="VDM23703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ER72"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="799" mass="88524" checksum="9350A894DCDBFA9D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXK4</accession>
    <name>A0A3P7EXK4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein jagged-1/2 predicted ferredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005960">
        <property type="protein sequence ID" value="VDM26073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXK4"/>
    <dbReference type="OrthoDB" id="6274049at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein jagged-1/2 predicted ferredoxin-like" evidence="1">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="149" mass="15977" checksum="B10A4A34C2A46891" modified="2019-02-13" version="1">MLSAPPPPPLCLTPPCYARAQCVNVSSTEMSSMPTAPLGLPPALPGCRPASVRLTNQCARLAIVVSRSRLPYGVTVEDFCNSVRALPAVEQTRASSNEGGLLGMSCGLAGRQPDYPSDLAYIEVRHLLFTCQSRILSVLLRVFIHSKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FES1</accession>
    <name>A0A3P7FES1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020416">
        <property type="protein sequence ID" value="VDM32343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6242779at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27538" checksum="832C52D0850F0018" modified="2019-02-13" version="1">MVEQDLDISNGIMFPFYDPDSNLIFLCGKGDSSMRYFEVTDDDPYVFFIDTMTSSDPQRGIGWMPKRGLNVNQNEIARFYKLHARGFCEVIPFTVPRKSVLYQDDLYPDTVGDTPALSADEWMSGKDADPILMSLKDGFVSGEADGKKNGKLPSTRPKLTESKLGGAHHQHQAPHSNTTSATTDSIRPSHTSSNAVSAGGEIVKSSDFGGINPEEVQQLLDDMRKMKIIIKGHERRIKHLEEQLKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FHI9</accession>
    <name>A0A3P7FHI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021936">
        <property type="protein sequence ID" value="VDM35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274045at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="216" mass="23880" checksum="FFDF2130B3EF42A5" modified="2019-02-13" version="1">MFGLFVFAILSDQVRKILLLLGESRSIKLVLFIHMLSAIFNDETAVEHVQRVNPRDDRKQVQRLLNGEDGDSEIGGYRKLSKFELLRDVCGSXXXGESRSIKLVLFIHMLCRGIFSSYFSTTGPLWLWPLPCLRPRRPRAFTWSMDAVDFRGVDSTGGIVSSVTTAINPPANAAIDVSANVPLLSALHDEIDENDTAAPLKSDDTTTHVISATSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FWE1</accession>
    <name>A0A3P7FWE1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024878">
        <property type="protein sequence ID" value="VDM36946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FWE1"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="70" mass="7883" checksum="6CEFC635D2B7499F" modified="2019-02-13" version="1">MDMQSVELLIDFNFVALLFYLEQLSFIIDANSDFLVASAVMTASDEQQHSLLLDSRTTQEGLKKLPKACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4F8</accession>
    <name>A0A3P7G4F8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000217">
        <property type="protein sequence ID" value="VDM17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4F8"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF14">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="139" mass="15604" checksum="624CB99A6D20D8FB" modified="2019-02-13" version="1">MGYRLCLYEFANLLSVYSVLVYRFIGGDVSFNPNIDARTFDTICSEQKGGQVFDVREPAELETDGRFPNAVNIPLGEVDSAFALSEADFKAKYGVPKPRVTDDNIIFVCKVGKRSLTACKSIEKYGYKKYGFLFIQGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H1W1</accession>
    <name>A0A3P7H1W1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010118">
        <property type="protein sequence ID" value="VDM28142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H1W1"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="62" mass="5780" checksum="0439C61D1B93F27D" modified="2019-02-13" version="1">MRLDCPSAALPHPPPPRSPPPAAAAAAAAAATAAAAAAAAVSSSSPLRQPPPCAVACLVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HNT5</accession>
    <name>A0A3P7HNT5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023714">
        <property type="protein sequence ID" value="VDM36322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HNT5"/>
    <dbReference type="OrthoDB" id="6271769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="278" mass="30639" checksum="7C08C543386AFBF3" modified="2019-02-13" version="1">MKLKPNRPLQAIYFSFRSTDSEASDSSVSSGQTCQIKRIASFNRPQRFFTLSLPRTSEKTILLHVPSTEAVTPTNQPRRPVNCSPDIPTIFLQPPDPDEGPKTPTLPYNDATEITMAKELSTKEEVVKSHEEQPPLTIKSTNEEKKVERRGSSNVKGGESSDKDVEKNKGNEEIGDKNNECRSGDQNENISSKVEEEEAEGRTYLSPMGENYIPDSTSQESLLNVASPFGDAAKVSFFTNLDSNRLRLGVLDLKVSNSMTSITIPLAGCAPTASQREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HPR6</accession>
    <name>A0A3P7HPR6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024277">
        <property type="protein sequence ID" value="VDM36572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HPR6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="175" mass="19504" checksum="9B33043FD1B2B8AB" modified="2019-02-13" version="1">MTPETLAQLEMRIFELEMAYKKYTTESYLVRSMLDHLSRRSKFLDHQRQKVASQPISHPPPPLPPQPVLHPAAGAAPFQPASVKVRPSHQEELCDPMMRTLAFLQYINENGGPIMMQSSSRDQALLLNNLLSRENGSEVTETMDNGASRKMSPSVGGGIKDGALIDVFQTRIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHM9</accession>
    <name>A0A0R3WHM9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS54</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000003">
        <property type="protein sequence ID" value="VDM15723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHM9"/>
    <dbReference type="STRING" id="6205.A0A0R3WHM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000005301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000005301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000005301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM15723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000005301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39730" checksum="4E76B5494A670BEE" modified="2016-01-20" version="1">MNVDSPNSPIDENSSQDNISVLVHPLVVLNVSEHWMREKLALDSTAVVVYGALLGKHRGREIEIFNSYEILVSEDMTVDREYFAARESQFKQVYPGLDLIGWYTTGGPITDENKLLNSRFIEGGESLIILKLNPLEKSGERLPIRVYETVVGSDSRVDFKQIPYTLAHDAIEHIGVDHLARVNSSANSANGRSGGVGSAADDISPTAECLMGNFHAVQMLSKRLHLLLDYVDAVMHGELPSHPGRLREIRALLSRLPRCIESENTDSGAVSGGSNSSSVSGDDDANSVLRQANDVCLSSLLGGLTRALQSLHSWICQERVVAACKDASAKGSGVGTTTSSQRSRPTFKMPLPPHAVEVVAAGEDGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHU0</accession>
    <name>A0A0R3WHU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000008">
        <property type="protein sequence ID" value="VDM15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WHU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000012701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000012701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000012701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6337960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000012701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19929" checksum="A5C44C8054437596" modified="2016-01-20" version="1">MGGVSAPMCKAHQDCEFSPLPTVQKLKLLDIDPRSPTDGIVRTPIILDKTSNNEGLQPFIGRLPFDTSDFESIDGCITEDDSVHNARNTSALSDNTVSTNNIKGQKKGVLTRVRRSLMSRRVHNSPSLMVKLRQREKIEHSKQQYEQIQKYRACQEGEGVLVAVETKISKLSSSNFGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHX7</accession>
    <name>A0A0R3WHX7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS169</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM16006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WHX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000016801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000016801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000016801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF566">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="967"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1417"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM16006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000016801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1438" mass="158438" checksum="C002E343E0681085" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI53</accession>
    <name>A0A0R3WI53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000017">
        <property type="protein sequence ID" value="VDM16155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI53"/>
    <dbReference type="WBParaSite" id="TTAC_0000025601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000025601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000025601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000025601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8061" checksum="12C9744EDDD77827" modified="2016-01-20" version="1">MAAWRLLLPPLPYQPARLPSGTAAAAAVYTGATAAVALWVCACKSLTWYGCLCALLLCNRSTVWCKCGSKTAEEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ63</accession>
    <name>A0A0R3WJ63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bms1-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS693</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000079">
        <property type="protein sequence ID" value="VDM16852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ63"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ63"/>
    <dbReference type="WBParaSite" id="TTAC_0000069201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000069201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000069201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
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        <source>
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        </source>
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    <sequence length="1266" mass="141382" checksum="1401835E59CBD60F" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJE0</accession>
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        <name evidence="4" type="ORF">TTAC_LOCUS788</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM16992.1"/>
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        <location>
            <begin position="1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="474" mass="53693" checksum="9678FED449829D6F" modified="2016-01-20" version="1">MANHFLLVVGLALLVRGSVYDEFKQWDPIHWIVKSTDHVELPCYHPRYYPFNKLDSILKVLWILPEHTSYMRMGPGSASEGWKVMGKDKKYKIVIEKSKMSQPETVNGMYLCAALAEVALSTGGNKTYYWPFTYAWVSVLVALAAVGLFSSAVHFRYKGGPKASSDAENFDTSSDTLTEDDNQSYSMKAEKTRGFELSLEINLFWNSLCISVNKRHRSRLQQTHSLFVSFSLQIDRLNRLKMAYFLLLAITMAALVSADIHDDFPQWDRIPWVVRSTDTITLNCTHPVHYPFTDIQSALSVQWILPKAASYRHLKEGETEEGWHVTTKERNYQLKINKAIMNVPDAVNGMYVCAALAPASKNPDGSAATYAWYYLRWGVGLYTNVPAMNEGTTAQKYYWPFTYAWVSILVGLTIIALFSLTMHFKYKGGPVKGDDDEGVGEDGLSLDDEDEKTSTIGKKDRNLKIDDDDIDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJP2</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000090101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44423" checksum="9AD92EC22E8A4E4F" modified="2016-01-20" version="1">MESQLMPNGEGSSEPQQYGMVPWLALMQKHMDSFARPSNDNTEEKILQWLRSLNDLGLMQANFLPQEEQREEEPSSTEPTAIRALATFLPLLPQSTSSPRPDLQENIGEGLSSAAPSQGESPLETQVKNSSPFFQPLTLDSISKLSQQIVQPLMQQQMPLQSTPSHLQMQPTVLTDNILRKCLRANGSVLNSATIFIPVGKQQPQKSVVESEAQRQGRRRVLFTAHQINEMLTRFKKQRYISAEEREELAYQIGLTPTQVKIWFQNHRYKTKRSGEYVPSNEDPATQAKIRAVGEDVPSTSASETSHNESLSNSETSHLQQQSAQASVTSTSLTLEVSADQMQDTSGQRVIFQALADFLQNQFDHTAAQKQSDEEDSGESKRVAQTKEIVRLLREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJV3</accession>
    <name>A0A0R3WJV3_HYDTA</name>
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        <submittedName>
            <fullName evidence="7">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS971</name>
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    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000145">
        <property type="protein sequence ID" value="VDM17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WJV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000097001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000097001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000097001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132832" evidence="3">
        <location>
            <begin position="23"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="4">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000097001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="75927" checksum="8765ADC1175F5B3C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJW6</accession>
    <name>A0A0R3WJW6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS987</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000148">
        <property type="protein sequence ID" value="VDM17273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJW6"/>
    <dbReference type="STRING" id="6205.A0A0R3WJW6"/>
    <dbReference type="WBParaSite" id="TTAC_0000098601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000098601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000098601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000098601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37028" checksum="9A531C88C625E0FC" modified="2016-01-20" version="1">MAVRIGCGRERLLKYPVLLSKCAKESKLYSNCIKSQAEVQRGVCEKEFLALLGCLQGPSHVSLFPIPPWELINKYTDNAVSLGTAPLPPQILPSTSYQTFGIQYSTDDPILRPLESFGFRRIYPQTCSRKAELKKLNFSILANYLDLLDIVTRDPSSLKRREKLDHIGQLFINMHHLLNEYRPHQARDLLREMLTYQVLQSSIPLTSNSTSFNLSLLVKIASETVHLGEQYLVRANETLSSAAQVISTDLSSTGTPISFEDLGPELNAFLVGIQADMKNNPPTATIKMCEDKMDLVTELSPPSPSPSENTSGGHSDSALDPCVWSFLEQANLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKN7</accession>
    <name>A0A0R3WKN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1282</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000246">
        <property type="protein sequence ID" value="VDM17738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKN7"/>
    <dbReference type="WBParaSite" id="TTAC_0000128101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000128101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000128101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6496929at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132928" evidence="3">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000128101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15805" checksum="2AC66A4370ABCE0A" modified="2016-01-20" version="1">MSRGRVAFFLFLIALLTAALSVKALKCYQCESLKQKGCYPLDTKLIKPTECPLGSQVCTILRQEAQFKQVYGEEQEPKVRYLRGCSSEESKGSYYCVERAGTGSNTKNKYCTCDSDACNPAVKNAVLRGGLTVLMLLLISNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKV5</accession>
    <name>A0A0R3WKV5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein lin-7 homolog B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS1361</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000276">
        <property type="protein sequence ID" value="VDM17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKV5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKV5"/>
    <dbReference type="WBParaSite" id="TTAC_0000137401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000137401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000137401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056216at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000039">
        <property type="entry name" value="Lin-7 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="16">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000137401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21332" checksum="0235632AB7812888" modified="2016-01-20" version="1">MAEPLNLQSDIERAIELIDNLLKCPDLQPAKLASLQRILQSDFFSMVREVYEHIYETVDVTGSDKVRASATAKATVAAFAASEGHAHPRVVELPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVAHRQGKLKRGDQLLSVNGVSVENENHEKAVELLKSAQGTVRLVVRYTPKVLDEMEARFDKQRTRRRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLY1</accession>
    <name>A0A0R3WLY1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1756</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000491">
        <property type="protein sequence ID" value="VDM18496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLY1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLY1"/>
    <dbReference type="WBParaSite" id="TTAC_0000176901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000176901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000176901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000176901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="17939" checksum="3264EB83CC97C7E9" modified="2016-01-20" version="1">MPDVFLLQFLPFSKDVRLPVQLQRAMAAEAEAAREARAKVIAARGEQKASQALKEAADVINESPFAIQLRYLQTLSTISAEKNSTIIFPLPVDLVTHFMQGKPSSSSLSAIPPSAAFTLGGGGGGGGGDSSDSNHAAASAGGHQGFGVPPPARRRQIVGAVTTSPTAANEAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLZ0</accession>
    <name>A0A0R3WLZ0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1765</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000495">
        <property type="protein sequence ID" value="VDM18505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLZ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WLZ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000177801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000177801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000177801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF68">
        <property type="entry name" value="PALMITOYL-PROTEIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000177801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="27911" checksum="7AA14D957F09ACFE" modified="2016-01-20" version="1">MALLPAEIIESRTRHTASLIFLHGLGDNGYVFGLNPSNWLPSSSGWADTLRNVVPPYCKIVCPNARDMPVTLNMGMVMPAWYDLYNLGIGAKEDESGILEATKEVAKWVAAEKTAGISADRIVVGGFSQGGSIAFYYGMTNVEQKLGGLVALSCWLPLHEKFVSNSSVATANRSMPILQCHGKVDPIVPYELGTLTNSILRKLGFANCSFSSYQGMGHCSCSNVGCLFTEFMPSWNWLWEIADVKTFLSTCLPPANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMA6</accession>
    <name>A0A0R3WMA6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras suppressor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1881</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000579">
        <property type="protein sequence ID" value="VDM18621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMA6"/>
    <dbReference type="STRING" id="6205.A0A0R3WMA6"/>
    <dbReference type="WBParaSite" id="TTAC_0000189401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000189401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000189401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000189401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25137" checksum="FBB611E0E4498D34" modified="2016-01-20" version="1">MNKLKSFKKGIEDVRQGNETALEASKKELTSIPELPELELRGLRSLILGMNRLDALPRGFGAFPALEVLDLTYNNLATLPDNFFNLGTLRALYLSDNNFEQLPAGIGNLSNLEILALRDNDLIYLPPEIGKLTRLKELHIQGNRLTVLPPELGNLDLTGPKQVAKLSGNYWVSPIEDQLQVGLSHVFDYIRSETYKFLHDRHLTMDPPVPPKADRSKKISRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMB7</accession>
    <name>A0A0R3WMB7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1892</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000588">
        <property type="protein sequence ID" value="VDM18632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMB7"/>
    <dbReference type="STRING" id="6205.A0A0R3WMB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000190501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000190501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000190501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6230928at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000190501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53494" checksum="215BB3C0ACFF562C" modified="2016-01-20" version="1">MTTRAFSNSSNTHEEDVHPLSEIMCNCELCYARLCASTRQFTEEDLMYNLDPLDNFPFLNSSKIMPTYLPYGYDLTGSSMCGDANRVAVNKMTFQSAMNSETAFPMYPSPEWQYCSKVLEQVPCEGDFSLAALSNPQLYLSKESVIHLRLSAYVVLERSGTAYRLINYRNNSALALSENCQYGYVYHFNCRGLINIHHEKLSITFDKERQILLRTEKPSFVKNENEYYRLTMHHWAQCRPVSMDFFDRDRTPDILRKSGLDKVNEEPKLLDLVNSSVIQKDASGLTIYLGDARIEQRLNGDVSLSWMHGEQFNSLFVSPLTGGLSLSTRNLEIIATPKNEIYISFADFFVHVESQQMTVSSGAMSGRLNHVRSHPCLLRLVNSHVDSQSLPQYCPYMNHSQNSPMHSASKHGSHGRHEGNCKTSTGTNAPQIENTMNTHCDTMNAEEPIRKLSCGGNCPKSSDTPLLSKATTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMJ9</accession>
    <name>A0A0R3WMJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein tweety homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1974</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000652">
        <property type="protein sequence ID" value="VDM18714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000198701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000198701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000198701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="889"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000198701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="943" mass="103169" checksum="85646698A0BF27C1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMX6</accession>
    <name>A0A0R3WMX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2101</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000756">
        <property type="protein sequence ID" value="VDM18910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WMX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000211401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000211401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000211401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065037at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="225"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000211401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114120" checksum="3C0E31E3BBDC8A3B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN11</accession>
    <name>A0A0R3WN11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2136</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000786">
        <property type="protein sequence ID" value="VDM19006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN11"/>
    <dbReference type="STRING" id="6205.A0A0R3WN11"/>
    <dbReference type="WBParaSite" id="TTAC_0000214901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000214901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000214901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000214901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11524" checksum="1306453AD168BA37" modified="2016-01-20" version="1">MEKRGDLTFDKIFNQRLGYLIFKDYCLNYHEEPVPQIRFYEEIKKLESLETDEERITLGKEIYDQFIMKDLLSQSHLYTCLISMRDEVEIEMAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNJ9</accession>
    <name>A0A0R3WNJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2324</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000963">
        <property type="protein sequence ID" value="VDM19645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNJ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WNJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000233701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000233701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000233701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000233701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34713" checksum="FC2EC381F0E57A14" modified="2016-01-20" version="1">MEHYVISRYYRPQHVQPAALYGKVSSLNRPSYDMHRIDADQFTSLFHAQTSWGHLSLPLFRLLDADNDNLINMRDYVWLLLLISSSDYYGKLRLLFTIHSSEYLRPEDRIGFWEQHSSQSPSTASCDLSSSYLSGIGVECAEELFEEITNADFNRVSRNENAVVSSKPPDILKRNGGARSIEYEWPSCRTALTTIYTGPMALENPPPLPKSSFIDLLKTISALVTDQKGDHELLHALAKIGKQCHLAVIKRNTGLKESGVATDVVWEIEFNDFMAAIDATPLVLPLAHGFTMMDRIPEAEEFLSSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPP8</accession>
    <name>A0A0R3WPP8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2723</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001432">
        <property type="protein sequence ID" value="VDM20984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPP8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPP8"/>
    <dbReference type="WBParaSite" id="TTAC_0000273801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000273801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000273801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="186"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM20984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000273801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42532" checksum="AAF1E9198D3EECFE" modified="2016-01-20" version="1">MLKDIRDSRRVSALIADTARVEDGNGAEAATQEHNPTYFPLQAYILSGEYWPEFHHEQFKLPEGLTPTFSQFTSHFERMKGNRTLDWMAKLGLVNVTLELGGQSITMDVSPLQASILHLFTLKPLWNLCDISQQLETTTSAVRRSLQPFVQRSLIKWTSGDIETYCVCNDVMKAEVEVGEDHNESINVSVAEQEGPHDMETSPVRETAGTDPQVFWSYILGMLTNLGGMTMDRIHSTLRMFALGSNDGVECTRQHLRQFLERKVRNVDIKKTSPLEFDFRAKFFPEDASQELIQEITQRLFFLQVKEAILKDKLPCPPETAVLLASYACQAKYGDYDVARFAKHPIPIDRLLSPKYVSFLALCSCVESQIDTLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPZ6</accession>
    <name>A0A0R3WPZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2821</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001551">
        <property type="protein sequence ID" value="VDM21249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPZ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000283601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000283601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000283601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000283601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19999" checksum="5D2A57769838F899" modified="2016-01-20" version="1">MSINVTEIVRFVGCGDLVFTKVAVPKFSRKLKLNLSQFEEKQLNLGPSFHNYSIRSRFLDAILAVLFHEVNISETREGSLALDVWELPANFCLEDTPSLISYFDFLPHAYRFLQEAVNHLRMNDDTVKELGNDILSVLVAKITQLRGTGILTSAEENRAVALVRSVQEKWQNRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRZ5</accession>
    <name>A0A0R3WRZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adaptin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002575">
        <property type="protein sequence ID" value="VDM22796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000353501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000353501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000353501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195736at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000353501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="26803" checksum="BFFC453B1022451D" modified="2016-01-20" version="1">MLLIYKWKCTRSSSQAPTLNCPGFSSGGPCTPGLTIFVHLVCTSTNESVHRAALGVLAEVAQDRDSLDAIASVPGISTRLNELAGSRNEAISTYASTLILRLTAPPATAPSSTEDALTGHGKVVVDSLTTPPPPPLPMDTSGSAGGRISPVAASACFPPQQLFHQHHGQPMPYAAPPPQQQAQSAQRYTPGGYHYSGEAVAGPGGGGGSSGSLMAMVGPPPPASSVYSVSGGGACPMSVQSLPPQQHPHCYQQQRNFFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSA9</accession>
    <name>A0A0R3WSA9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3634</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002779">
        <property type="protein sequence ID" value="VDM23033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSA9"/>
    <dbReference type="STRING" id="6205.A0A0R3WSA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000364901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000364901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000364901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8020218at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000364901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10690" checksum="C4D9FD1BEEF4F94D" modified="2016-01-20" version="1">MSLCEVGGYVVYSTCTLSTAQNQAIIEFCLAPHKGNDESEFAVVDSTAFVEICVSQLKPSLGVRVVPAYSTTGLALGVTVIPRLAANYGPTFICKMKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WST0</accession>
    <name>A0A0R3WST0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SP-RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3805</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003087">
        <property type="protein sequence ID" value="VDM23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WST0"/>
    <dbReference type="STRING" id="6205.A0A0R3WST0"/>
    <dbReference type="WBParaSite" id="TTAC_0000382001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000382001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000382001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285798at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000382001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="7514" checksum="DE5FEA3B10AF0674" modified="2016-01-20" version="1">MDAVPTGSSPPGEYGQVIPPNPLTGLGSPGSGMMPCTSPHTGNSPNVQPAALTTLGVDAKSSKPPLLPPQLLQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT05</accession>
    <name>A0A0R3WT05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003216">
        <property type="protein sequence ID" value="VDM23664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT05"/>
    <dbReference type="STRING" id="6205.A0A0R3WT05"/>
    <dbReference type="WBParaSite" id="TTAC_0000389501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000389501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000389501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18631">
        <property type="entry name" value="CD_HP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM23664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000389501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30897" checksum="589A3DB7D015DEC3" modified="2016-01-20" version="1">MMTEVDLHESEDSDIGEGEYQVEKIVKVRIRGGKKEYLLKWKGYADEDNSWEPEENLDCPDLIKDFEERMLRERSSVLTPGRPSSSSAKVTPRAKLPCPPEALRKRGRPVHSDPEEFASDPKRVADESSNIVHKSPSKTARGFARGLKPDRIIGATDSSGELMFLIKWKDSNEADLVPAREAHVKCPQTVIRFYEERLTWHTPEPRTESAQLTTGSISATVQAPVQTLESAAVPSESDPPAVTGEESNIGPVDSGAVVAVAEAPTPGSASEALVTQAELAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTP8</accession>
    <name>A0A0R3WTP8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4124</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003720">
        <property type="protein sequence ID" value="VDM24236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTP8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTP8"/>
    <dbReference type="WBParaSite" id="TTAC_0000413801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000413801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000413801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000413801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21700" checksum="949A938B78873597" modified="2016-01-20" version="1">MLQPKFLKECRYALESFYGHLPNIDTKDYGRIITTEHTERLREMILKTEGRLVFGGLVNVSGKFVQPTVYCDVPEYDVLMLHEIFGPILPVITINSSEEALEYVSNQRKPQALYVFSSKKSIFKKWKKHSESNVIMHNDVAMLKGTRKTFGGVEASGFVRYRGKSSIELFSRYRGVIERYKKDDGDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTU0</accession>
    <name>A0A0R3WTU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003817">
        <property type="protein sequence ID" value="VDM24333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WTU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000418001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000418001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000418001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000418001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33708" checksum="13FA982C6E3B3095" modified="2016-01-20" version="1">MITAPGPSGGLRFLPAHASPTVPCVTPPQPTFLPKISVRRKISSPVLQSEKSGDFFGPPSPLTSGVPRFTNLADYMDELASAAPQNYAPIGQNASTKSHLLGRYETSPSSFRCLPAPSKTTPTLPATDQTSNRLFTVSIWTIITVSACVGHHEFFISPNLYLRIMQNLSTIPSHSQFTSTPPTDDAPPPPHKIKRKTLVPRIHCLDPEPTSSTFCSSATSTSFRKSLNSWRRRRSTRRDVDLHLAKHGDDIPTAEASRLSRCRLLENFAHDEVYLSIDSESLAFLACSQTSASSCLRCAKSHLPAKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU75</accession>
    <name>A0A0R3WU75_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS4299</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004110">
        <property type="protein sequence ID" value="VDM24635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU75"/>
    <dbReference type="STRING" id="6205.A0A0R3WU75"/>
    <dbReference type="WBParaSite" id="TTAC_0000431501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000431501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000431501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045438at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM24635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000431501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14702" checksum="AF64FD020D4A9625" modified="2016-01-20" version="1">MSGRGKGKKNTARNHKSRSFRSGLQFPVGRVHRLLRKGNYAERIGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIVPRHLQLAIRNDEELNKLLSNVTIAQGGVLPNIQSVLLPKKTASDDAKKAQSQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUD8</accession>
    <name>A0A0R3WUD8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS4364</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004233">
        <property type="protein sequence ID" value="VDM24761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUD8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUD8"/>
    <dbReference type="WBParaSite" id="TTAC_0000437801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000437801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000437801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15572">
        <property type="entry name" value="PHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM24761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000437801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35602" checksum="6DD121804CDBE517" modified="2016-01-20" version="1">MYQRKPPVWKKGCAYLRFVERSPEELDEIDLFWLEKINADREAKGMEPVEQSKLEWVLDRFEKKAQFRSTEDAVCAVCQDGNCENINAILFCDVCNLAVHQDCYGVPYIPEGSWLCRKCLHSPSEPISCCLCPNTGGAFKKTSDDRWAHVICGLWIPEVMFANLTFLEPLEDIDKISSARWTLRCFICKQRNVGACIQCHKQSCYRAFHVTCAQQAGLYMKIEQSDDPNDLGIRKRAYCDRHCPPSHFKARFLLPREEFFQRVYAFWKLKREVRRGVPLLKRLQAATRIRGAASLVSIKLFVEVIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUF8</accession>
    <name>A0A0R3WUF8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4383</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004286">
        <property type="protein sequence ID" value="VDM24808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUF8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUF8"/>
    <dbReference type="WBParaSite" id="TTAC_0000439801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000439801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000439801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263085at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000439801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7263" checksum="A2006A882D060962" modified="2016-01-20" version="1">MQSVERWINSIPLDAPIYIQTSLTQIMPISDPKSFPDELFVSDHLPSTPNNSSSISAAGDTSRGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUP7</accession>
    <name>A0A0R3WUP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4472</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004535">
        <property type="protein sequence ID" value="VDM25030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUP7"/>
    <dbReference type="WBParaSite" id="TTAC_0000448701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000448701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000448701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6243760at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000448701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14660" checksum="4577FDEB9629ECFE" modified="2016-01-20" version="1">MTLLRLLFYPEVIFIRKLVARVESQNIDAGSEFLLLITSLLLASLQASKTTFGEAKMVSDFIAERMLDVADSEGLADAALPLARCYDLLEELRTECNQHCHDNAPNVNACLQNCWGGWKYGRLTCRLRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUY9</accession>
    <name>A0A0R3WUY9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1794 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4564</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="UYWX01004767">
        <property type="protein sequence ID" value="VDM25194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000457901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000457901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000457901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247413at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000457901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20715" checksum="DA9CA94D0798CE89" modified="2016-01-20" version="1">MTQASTMPSSRLTACAIHSSLQPFAKLIGEWEGEGSMSLYTQTTYPCSENISIGHVGQPSFWYSSRAYSGGAFRHRDMGFMFFNQETGQMELMTSDNTGHVHILKGPARNEHGRIHIVLETELTEGHPLPKKPKMLRVRREIALLDNDTLTQKVFMATEKKTDMTLHTNMIYKRLPKLPGSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV01</accession>
    <name>A0A0R3WV01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004799">
        <property type="protein sequence ID" value="VDM25220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV01"/>
    <dbReference type="STRING" id="6205.A0A0R3WV01"/>
    <dbReference type="WBParaSite" id="TTAC_0000459101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000459101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000459101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053076">
        <property type="entry name" value="WW_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46697">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46697:SF1">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000459101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34898" checksum="B20DEC231BE11FF3" modified="2016-01-20" version="1">MLPRPLSPPLKAVDALIIAPRTNWIVQVDSKSNLPFYHNFVTKETTWDLPDEYQSYLDAYKTYLQHKNDQSVVKEEEKKESPVLILPEGNARKRRRIKRAFMRANAGGANLSDAPVEFLSEYIAYSDSSSEDESLDSKRSSQTPTINEPMEVINETPESSKVFIGPQLPSSSPECEVMSSSPDELGKMLLNKFAIVCTDSDKLSRLQVVRIQFTTRFEDWKAGHLSDARYKEKLEEVSNFLREYEQGMQLKTSRQCSSTMTSPPIYRSESAIHDQVKEVLITFITAPMLIFPFCSEKHENHTTRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVF4</accession>
    <name>A0A0R3WVF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4730</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005190">
        <property type="protein sequence ID" value="VDM25540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVF4"/>
    <dbReference type="STRING" id="6205.A0A0R3WVF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000474401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000474401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000474401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000474401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17224" checksum="EA10FFE65290A164" modified="2016-01-20" version="1">MQNWYHLQHDQTGGNQLFASAVSLRPIADAGVHVNPSIRREIVRKLEREMDLPANRKDFFYSASMVHVNEYVSSSNVNEYIRSVTKIGEGETEAEGTVAHPSNHVVKMLSELFDFALLRSPTFLLLLASSVFGLLGESVSLLNPFLHFSAWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW19</accession>
    <name>A0A0R3WW19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4945</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005736">
        <property type="protein sequence ID" value="VDM25927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW19"/>
    <dbReference type="STRING" id="6205.A0A0R3WW19"/>
    <dbReference type="WBParaSite" id="TTAC_0000495901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000495901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000495901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000495901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16776" checksum="6C40E3D23E7106A0" modified="2016-01-20" version="1">MPHITACSELKDTEKLLWYYDQIEKQCLSTSDCILNDNRFQSEADCKSACLPKSPLNRCLVPPKAGYAQCAYSGNRSGPSTTIQKAYYDKVHERCSWFVYLGCGGSDNQFASIEECNDSCMTPEALTTIRQSRFSEKISLRPFNHQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWF5</accession>
    <name>A0A0R3WWF5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bestrophin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006187">
        <property type="protein sequence ID" value="VDM26215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWF5"/>
    <dbReference type="STRING" id="6205.A0A0R3WWF5"/>
    <dbReference type="WBParaSite" id="TTAC_0000509501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000509501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000509501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000509501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14628" checksum="E83D8942E948F53D" modified="2016-01-20" version="1">MSFFQLCLQLVDTGGRLVENEKGTQPTILRSQAVSTLTAFVPLHYDCLVPSMKDIKKMIESGFWLDREENRSFRIPLLRFCDALLTHAFECLEEKEKEEAEPDYDWWLRISGTLVSIAGAMYYASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX50</accession>
    <name>A0A0R3WX50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5324</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007051">
        <property type="protein sequence ID" value="VDM26699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX50"/>
    <dbReference type="WBParaSite" id="TTAC_0000534001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000534001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000534001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000534001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="65" mass="7174" checksum="FAFDFE4545DB9117" modified="2016-01-20" version="1">MNSPSLSELSSEAEFSDSLEDAELDEEDSEDADEDDDDSDLDEDVYGAVECIWLVEGTKCTGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXH2</accession>
    <name>A0A0R3WXH2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5447</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007551">
        <property type="protein sequence ID" value="VDM27017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXH2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXH2"/>
    <dbReference type="WBParaSite" id="TTAC_0000546201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000546201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000546201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000546201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16724" checksum="F8B416ED9FC928D2" modified="2016-01-20" version="1">MEPIRTLLLRHAMFQHPDELFFATLAYNPHLKLPGACLTAPPPRSEVNLGFLAKFVIWSDYKMHCPTLYTRSVCILGTAHIPQLRRAPHLFANKFYSDYQPEAYDEMEKWYFEKLAKEIASETYAADAFNVSVYANRTCSRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXY8</accession>
    <name>A0A0R3WXY8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GOLGA2L5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5614</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008224">
        <property type="protein sequence ID" value="VDM27325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXY8"/>
    <dbReference type="STRING" id="6205.A0A0R3WXY8"/>
    <dbReference type="WBParaSite" id="TTAC_0000562801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000562801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000562801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978643at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024858">
        <property type="entry name" value="GOLGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043976">
        <property type="entry name" value="GOLGA_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881:SF46">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15070">
        <property type="entry name" value="GOLGA2L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A conserved" evidence="4">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM27325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000562801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23893" checksum="31F59573584F388E" modified="2016-01-20" version="1">MALCQTECSLVKSEELLAQLRIDLSQSKASYAQLEERFKQLTDRLVASDEEKSRLEAVVAQLEMESSTIDEYVTMFAHRRQLLLERAKIREALLSRLIRDRNELRQRLQSLSEVANAVIASSSVPGSGEQGTCASMSDFEKSLSEFLSHLATSNADYSLQFNVEDSEGDDDVNKSTTIENGSTQGGSLDEQLRRYVSAVHDCPHCECCSGSLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYH5</accession>
    <name>A0A0R3WYH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009126">
        <property type="protein sequence ID" value="VDM27691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000581501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000581501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000581501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000581501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26864" checksum="EF2D6456C367DC9D" modified="2016-01-20" version="1">MEGVARCIVKWSVAPLLVDAQRGALLTLEGEERVHRREVMHHCARLSQLARDDVDLVAATLHDNRRWQWVVHEDDIDVHEQAARCLLLHTVSRCPPSQHRWMEMFGLVGDTSLQANVTSSVTTSVHCLGVGGGGDSDGVVVRVLCVCCCNPLNFHPMGKREKSSKCRIFLPGEVCGFEADGLALHLAELEAVVRGRCGSHEGAVADAVEKASSRDCVHLSLLVRAGVSVAVEVYCHRVLMMESRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZX5</accession>
    <name>A0A0R3WZX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6366</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000638101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000638101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000638101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267990at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000638101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="124031" checksum="311FA90D95132289" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0G7</accession>
    <name>A0A0R3X0G7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0G7"/>
    <dbReference type="WBParaSite" id="TTAC_0000662401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000662401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000662401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273232at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000662401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40923" checksum="D5FEAC76F1A3388A" modified="2016-01-20" version="1">MSELLVAKRVSSPIRPFELCNVSWQFTLIVKLKQFASKPHILPADVYFVVVGIGDEISEYSSGPSDVVRSFGFPLKSLPNNYSPTQTLDQFVVTGQARGNNFCFQSPSGERFEVIPVLCQVKRISSRQARSENGIPLASQRTSQVVYSFFKDPKLFSAKLLTMFVSLFATITGHRLLICRKSILDDFLRTSSGSCQTEILHPGLNHEEHESIYVICPLNVFAMQLEIIRMKMDGRSDRCRQLERTVRDQEKIITLLENELQRTRVRESRSRFPTPRGAEGAPPVSRGSGENSYLPFSSDASRSRLRSSPSRSQPSSITPSAPVDPSSVPVLARRVRSLVRDIREETEASLLRCRERSRAPREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1A2</accession>
    <name>A0A0R3X1A2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1A2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1A2"/>
    <dbReference type="WBParaSite" id="TTAC_0000696501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000696501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000696501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064600at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000696501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="59458" checksum="096202DB9392EA4F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X281</accession>
    <name>A0A0R3X281_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7363</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020365">
        <property type="protein sequence ID" value="VDM31731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X281"/>
    <dbReference type="WBParaSite" id="TTAC_0000737801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000737801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000737801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000737801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8374" checksum="E6C820DEFF858A8A" modified="2016-01-20" version="1">MTEDANTNAAATDDYLPLRITVISKGPLTHHNSNNNSTGHHCRRREEVSGTGEGGKEIERWCGARDSRSRVIAHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2R3</accession>
    <name>A0A0R3X2R3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome-binding factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020386">
        <property type="protein sequence ID" value="VDM31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2R3"/>
    <dbReference type="WBParaSite" id="TTAC_0000759901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000759901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000759901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273535at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000759901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28971" checksum="349D30616219CB4A" modified="2016-01-20" version="1">MLRGLFRDGFIFKVAPRTIVNHCLMCYASLHTKAPGDLSSELSVSTHCDNAYLMRKYKRRLLMILASIDTDEPLSQVEITNLAASPDGRILTVFWTVGAHPYNEAANRKVDFILQNASKKIRQRLSRENAFRKVPTLNFIHAPTNFSADPPKEQVDADSCHIVKPNNVYGLPWDKYMDEVKRKRVGDVVMVDTENGSADCLRDKGLFSSRSANWAKMWQKQHDSKLIAKRERRRSQQMLGMWQLIKEMEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X385</accession>
    <name>A0A0R3X385_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SGF29 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7778</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020404">
        <property type="protein sequence ID" value="VDM32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X385"/>
    <dbReference type="STRING" id="6205.A0A0R3X385"/>
    <dbReference type="WBParaSite" id="TTAC_0000779301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000779301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000779301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="5">
        <location>
            <begin position="104"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000779301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29988" checksum="1714CDA738E82B15" modified="2016-01-20" version="1">MCNSAFITSQPISSQPSGSRLAVAEFLTVNHNVMELELMEKINELTEICKEVVVKIAKGPRNMRRGVLMSLLQESAKSIPMWVGSVNETPPPLCGAIGAGNNLDTNLVAPGDYVAALVPDLECPDAEFTPNESWILAEVISFNREKRQFQVEDVDAEEGKVRYTLDRSKVILLPKWKANPVLNPDAIFHKGTLVLALYPQTTCFYRAVVDTYPAHAHDEYSLYFEDPSYPDGYAPSIRIPQRYVILCPETDRRTARHSRNRLSYKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X395</accession>
    <name>A0A0R3X395_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7791</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020405">
        <property type="protein sequence ID" value="VDM32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X395"/>
    <dbReference type="WBParaSite" id="TTAC_0000780601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000780601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000780601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273326at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133162" evidence="2">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000780601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40508" checksum="56D4FA5ECD525577" modified="2016-01-20" version="1">MKALVLGALVLVLVTVAFCIPATGKNGKFTQHPTRSRGVKTSGESERTALGNELQNSGPGSEPGGDSTNQNANDSGRRGRKSEEKNRPRGRKRTEGTTASTTPATTITTSTAIPQIAESSKTPEPDFVFDNYKTIQEVDDAESINATTKSVSEESKNTKAGIAVTTDKMDSMEGKNKNKAPISKKQSSDKNAAKSSGLHEYHQSRPYLDYYQEVPPEYLMPQMEEFPYEPQSTSWNIYGHNFYPSSPMGGSPHWSPLQDQLYETLYNPMWPEEEQFYDMGPYWWDNMVQINKESCCSKKNKKKTTTTTVATVSTTTTAPTTTSSSVATELVATSLPTTTTTAAAAIMDTTATTISNTNSTWKRIEGLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X396</accession>
    <name>A0A0R3X396_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7792</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020405">
        <property type="protein sequence ID" value="VDM32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X396"/>
    <dbReference type="STRING" id="6205.A0A0R3X396"/>
    <dbReference type="WBParaSite" id="TTAC_0000780701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000780701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000780701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10320510at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000780701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="39593" checksum="A6B78B69E4E486AA" modified="2016-01-20" version="1">MSSNAFTTSGVSQQSVTATLSSFEVTDSSTLTSLDRKGDMTVVEENKSPEVLMGNESDGSTIPPKPETKSKSTVVSVDASEASQIADVKGLPEISEVFTILQTSENKVASAEGATAESKAKSSEVEIDFETSDMPSGAFVAPEAAFKPVEMLIPKPEVKTLTKEESRGGEVDSTTDWTIQLPELETVGKSASNGTLSNSFTASEATSTPVDMSASTLEVQEKTRDESDKSYVTSKPGEVHIGPNSNTKTPPLDESFCSSTPLEAALKPVDTLTLTPEVKAKKMQEIGESEVSFTTSMASEAIFKSVEKSVVDSEEEVIRYLIVLCANLLHGEGDAERAREIAIILTRLVHVCYQDVGPERYHECTPWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3N4</accession>
    <name>A0A0R3X3N4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavoprotein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7955</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020425">
        <property type="protein sequence ID" value="VDM32432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3N4"/>
    <dbReference type="STRING" id="6205.A0A0R3X3N4"/>
    <dbReference type="WBParaSite" id="TTAC_0000797001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000797001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000797001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000797001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21400" checksum="22204F306D950EB3" modified="2016-01-20" version="1">MEDSRRNVLLGITGSVAAMKGVELISCLMQSNFDVQVVITTNACNFLDKSLIEVPVYTDVDEYTYWGKRGDPVLHIQLRDWADILLIAPLSANTLAKIASGLCDNLLTCIARAWHSTGTTPNKPKKPAIFAPAMNTFMWENPLTSIQVDILCKTLNWTMIEPIQKTLMCGDFGKGAMEEPHRIVEFVQNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4E8</accession>
    <name>A0A0R3X4E8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8268</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020475">
        <property type="protein sequence ID" value="VDM32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4E8"/>
    <dbReference type="STRING" id="6205.A0A0R3X4E8"/>
    <dbReference type="WBParaSite" id="TTAC_0000828301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000828301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000828301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252596at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000828301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135406" checksum="CD5F3A49AD4B1609" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4V6</accession>
    <name>A0A0R3X4V6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8448</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020507">
        <property type="protein sequence ID" value="VDM33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4V6"/>
    <dbReference type="STRING" id="6205.A0A0R3X4V6"/>
    <dbReference type="WBParaSite" id="TTAC_0000846301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000846301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000846301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133199" evidence="3">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="99"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000846301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40980" checksum="19D2E0E5715AA26F" modified="2016-01-20" version="1">MAPYKLHLGLNLISAFVFVLADRRQNFNHTSECYCNGTNYCLNRDPKHENRSQPYCYYPPYSASKSGAHHVLYPSPLLYAQRHTCGRSPMWKSKVMPKIIGGRSSVSHSWPWMARLTPSSQAGVYLLSGGHEGKDGMYNDLDTTPHCGASLISSRHLITAAHCIMKFNSTTVLSTPANHWFSPVSYLQTQVLVRLGDHYLGGADEGWQKDMLVDEVLTYASDWGFLTYDIAILKLKKPVALSVGIQPVCIPPPNIQLAVGTKCVAVGWGHTEKTPDPGVLMETTIPIVSTTVCQNHSDYFKEGFHACAGGDKKKAWVGDSGGGLYCRLHQDDNQWYLYGVTSFGTTLRGPCVFTYVPRFADWIHRHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5H2</accession>
    <name>A0A0R3X5H2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020566">
        <property type="protein sequence ID" value="VDM33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5H2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5H2"/>
    <dbReference type="WBParaSite" id="TTAC_0000871501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000871501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000871501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000871501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13886" checksum="FC15FB2229893297" modified="2016-01-20" version="1">MSLEAVSCAMAPKAIGPYSQAILAAKTLYISGQLGTNPSTMELAGPSIDHQTEQALMNLSNIVKESGGEMKDIVKTTILLTDMEYFETVNKIYAKYFTYPYPARACYSVKALPKNALVEIEAVAVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5Y4</accession>
    <name>A0A0R3X5Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Enhancer of rudimentary homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8885</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the E(R) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020617">
        <property type="protein sequence ID" value="VDM33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000890001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000890001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000890001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000890001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42182" checksum="295FE1881CDC8535" modified="2016-01-20" version="1">MSHTILLVQQQVKKPESRVWADYETINQCLEGVCKIYEEQLKQQNPTAPTITYDISQLFKFIDQLADLCCLEFHSATGTYVPHTKDWIKENIYALLRNQADFNLRNYLREEIWQFSRRRNEVNNSQEQICGPFRNRVWKFLSIPQYFESFMFYGLLQCLDHILMVYTFLPLRCIIIFISLLSYVTFSLVGSCIPSFKPKNFILYATDVRELVKFSFVCICTIFLYTFDSSIAYHEIRTQSIIKIYIFFNLLEVADRLLSAVCLDAVDDVLYTVSAGLGRQRVFPSDRVVTTSSSVSSIDPPSSAEAVSLGAFIVQYLFALTCLAAHCLLLLAQVTTLNVAFNSQNRSLLTVIISNNVSSIVPCTSSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6J2</accession>
    <name>A0A0R3X6J2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Long chain base biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serine-palmitoyl-CoA transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS9113</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020683">
        <property type="protein sequence ID" value="VDM33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6J2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6J2"/>
    <dbReference type="WBParaSite" id="TTAC_0000912801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000912801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000912801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000049">
        <property type="entry name" value="serine palmitoyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="133"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000912801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57185" checksum="BCEA3B6E55966971" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6J8</accession>
    <name>A0A0R3X6J8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cat eye syndrome critical region protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9119</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020685">
        <property type="protein sequence ID" value="VDM33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6J8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6J8"/>
    <dbReference type="WBParaSite" id="TTAC_0000913401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000913401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000913401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000913401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="47760" checksum="0DB817BC2497AF28" modified="2016-01-20" version="1">MFSLAAHTDVRAFPRFFKQFIKRCVFTKKQVLRDISFRDANFGIAFDVDGVFTRGPLVLPDALRASEMLHEENGNWRIPVLFLTNAANILPSEIVTPNSALKIYSVFDKHVAVCGHGSLKAVAKSIGFKKISTIEDISANFPWLDACRPKEVLYSDALKRADFSKIEAKSPPPQLPIFVCGSDLVWASNAPSPRIAMGSFLCCLDTLYENLTGRRITYTGLLGKPNPLAYIFALSQLNAIAAKRFGATQPLKRIYCIGDNPEVDIYGANLFNLYLQTISDETWSPLFELISTLVQEEHPCLFSGPSTNKCDRPELLIEKAIKWSQLTRRSKTMLETLRELVIEKPKRSPPCTMEPILVTSGVYQETEGVPDEWKGLHHVLQDFSDLSHLYEPRFVSPNVAEAVASILSLECALGSSEATSIPASANGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6R2</accession>
    <name>A0A0R3X6R2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase_M3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9192</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020709">
        <property type="protein sequence ID" value="VDM33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6R2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6R2"/>
    <dbReference type="WBParaSite" id="TTAC_0000920701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000920701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000920701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="286"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000920701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="817" mass="90576" checksum="CC64FC9490A17532" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6W7</accession>
    <name>A0A0R3X6W7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020736">
        <property type="protein sequence ID" value="VDM34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6W7"/>
    <dbReference type="WBParaSite" id="TTAC_0000927201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000927201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000927201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000927201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19356" checksum="052A4233A509F2C8" modified="2016-01-20" version="1">MCVERVTNNGRKCNDKVMLGLQTQIPLIREEVSSSVCDEVIDLELPMSPQSDGVCTLLTLLSFYSLRPHFFTEHRGGILAGLSCRCTTSYWTGTLLSNTLQRLMPLTCAAATVASPLEGIGKESYGYLSLHLPGCLQSFDIIHLSGNLDNLFITDRGHPFLNSTVHATNQDLACEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7K9</accession>
    <name>A0A0R3X7K9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9519</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020864">
        <property type="protein sequence ID" value="VDM34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7K9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7K9"/>
    <dbReference type="WBParaSite" id="TTAC_0000953401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000953401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000953401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000953401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35860" checksum="ADE67D13691BB1B4" modified="2016-01-20" version="1">MSSRLLRFSSFIFGASTSSLLIFPWNRHNGDLNDKFVKVPACEKRGTWNHNWDLDEAVSTPPPTQYRRLKLIIFVRHGQYDTKGATPEQKVLTEVGWKQAVATGKRLRDLGYHIDCIVHSDMIRAQQTAAGILSELDHVHLAETGILKVMDKSSALADQEIVIRCSPLSSKCCLLLESPLMAEGPPPIEPEPNPPSRIKYLESLCPSELSERINAQNRIGLSFHHHVHRKPISETGGLAFRGGPTGRRPFEVVLFVGHANVFRYWICRALQLPPEAWLRISLPHGSITELLIEITPHSECTVTALRIGDDGHIPVELQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J2</accession>
    <name>A0A0R3X8J2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0029 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9852</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021111">
        <property type="protein sequence ID" value="VDM34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8J2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8J2"/>
    <dbReference type="WBParaSite" id="TTAC_0000986701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15650" checksum="83F589847A700057" modified="2016-01-20" version="1">MVSDIALQLVEAHCCVVNSLADVSAFISTILEDRKVAAASHNITAWYLQAKLKPDAPKTSLVADYDDDGEAQAGGRLLHLISLSAREGVAVMVSRWYGGIHIGPDRFKHINNAANQLLMQQGLTKNAADSGTAQSKSKKHVKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8U6</accession>
    <name>A0A0R3X8U6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9956</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021191">
        <property type="protein sequence ID" value="VDM34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8U6"/>
    <dbReference type="WBParaSite" id="TTAC_0000997101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000997101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000997101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000997101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27431" checksum="B3CD1D1F02BD07CE" modified="2016-01-20" version="1">MGEMEGIIATTETTRDEARGAGQDAITHAITHLLSTLRPHDSTTFRCQADPNVDAEESSSKPLIAATASDNMEMMQLLLEYGECTYFCDHHGNMTAVDLLCRYDSTANLQNRRHRAPIIEGRSHGHHDVVQYLLRVEHTETASKLDAFMPLLLPPLLLLSWQVMHDLSALSASCYCNKCMPMRDFPCLVNTLSSNTSSSLSSCFITLPPLCTSISPPLSSLRAIASLFIPSTPLLLCLLRSPPKRDEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8V9</accession>
    <name>A0A0R3X8V9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCM1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9969</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021202">
        <property type="protein sequence ID" value="VDM34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8V9"/>
    <dbReference type="STRING" id="6205.A0A0R3X8V9"/>
    <dbReference type="WBParaSite" id="TTAC_0000998401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000998401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000998401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000998401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="39868" checksum="473C7F9E525EABBC" modified="2016-01-20" version="1">GLERKCPPTPSNRLPSSSSSSSAKSSFSDSRHLSRTPPDQSSPWRVVQTSDSQPGLPRAPPPPPSVPVEDSNYLEKRDGEDQDGSTSAANTLTQSIRASFNPLSCREATAENDLNSLLRQLEEVENTMKQLEQDDGGFTRRYSLASSSTTDPNTGCNPSPAPDAPEQVTTSSPLPLATNGHSHIINADQLNAERVARKPMPIPPSVPLRPPSPSNTDYELADDTSVAALLAPSVAICTKPTNMVLHDDDLVDEAQGEREQRNDLQRYCSMEVASPSNQTQANRFSSIDSASVRRSSLAALRPPPPPPPLPSPQSPLGSSNEVSLSDKSVSEFPELFKKLNQVVDLADRLQLNKVLYYSLENALIEVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9G1</accession>
    <name>A0A0R3X9G1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trithorax group protein osa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10171</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021386">
        <property type="protein sequence ID" value="VDM35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9G1"/>
    <dbReference type="WBParaSite" id="TTAC_0001018601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001018601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001018601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001018601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="38774" checksum="12CD16A722596D4C" modified="2016-01-20" version="1">MESMTEPQKANETSASSLGLGAALAVAYDLTEDPNFSQPSYIHPETTSVPLPSMAPQSGVIVLSKNPYYPAFSAQSQPVRYHAGDPYWAVSGCPQVTQQHPQQQVPVTSAAALPMTAYLNPIPVSSPTSCPRGSENGSFFLQSVTHPPSASATTIAPSTADPTGYVDGGPASESTMSTDSMLSVRSDSIPTYPPASEMGYTIKTVSQASVMPNVGHHGGSGVASTSSLNNNTTSSTSTSRRHEDQRQAAVPSSGSDDGLYELSEEDVKEIDDMLTQNPQVTSSRHWKYYVETNEWTRATCALMACLFSRDQMANSTVLGRGGSQRERLPTNLVAYVVSKSTNLGLFKPPPPPPPPPPPPPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9S0</accession>
    <name>A0A0R3X9S0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10279</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021502">
        <property type="protein sequence ID" value="VDM35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9S0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9S0"/>
    <dbReference type="WBParaSite" id="TTAC_0001029501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001029501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001029501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001029501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37336" checksum="59672D47ED233438" modified="2016-01-20" version="1">MKFDSKDEIKVKKNDHPKISKVTVHPLVLLGVVDHFNRVGKITGGQKRVVGVLLGALRGSVLDVSNCFAVPFEEDANDPNVWFLDNDYLENMFSMFKKVNARERIVGWYHSGPKLCTNDIKINELFRKYTSNSVLVVVDVKTNESDGIPTEAYIAVEEVHDDGTPTTKTFDHLLSEIGAEEAEEVGVEHLLRDIKDSSLGSLTQRIDAKISGLSGMLRQLEGIQEYLQLVTTKQIPINHQVMYKLQDMFNLLPDVRLQEMVRSLNMTSNDQMLVIYVASVMRAVLALHDLINNKLANRESERNEDEGKKTTKPAVAGDQPKDETEKASEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA05</accession>
    <name>A0A0R3XA05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10365</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021598">
        <property type="protein sequence ID" value="VDM35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA05"/>
    <dbReference type="WBParaSite" id="TTAC_0001038201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001038201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001038201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283552at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001038201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23475" checksum="2CE9E7138FCA82C8" modified="2016-01-20" version="1">MDDPPFLLLFLKLTNYYAMLDRRQKLSRSGHENFRFIEFDFDPQSAILPSSAKMRRRFNKSAAAVRARMAQKCKDERRFGRVLPSGTIATNSDRSHLSSSSATGAASSSSTTITSSTSITTSGNNSRQSTLNRRRSAAYAAASAPLAKNPRLSLAPQPPPPPPLPLPSVAPTQLVATPPMLTSLPSEAYVPPSAVNSAPATASVVHDPPVILASAPEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA43</accession>
    <name>A0A0R3XA43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10403</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021659">
        <property type="protein sequence ID" value="VDM35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA43"/>
    <dbReference type="STRING" id="6205.A0A0R3XA43"/>
    <dbReference type="WBParaSite" id="TTAC_0001042001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7414" checksum="15FDCB8467ED0F9E" modified="2016-01-20" version="1">MMKSLPKEAAHAAAQARAQERLEALKNKGKGGRKPGAKVGKPRPPPKSSSTPGTGESEVPPPPHSPDAVPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAA4</accession>
    <name>A0A0R3XAA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome subunit beta type-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10464</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021730">
        <property type="protein sequence ID" value="VDM35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAA4"/>
    <dbReference type="STRING" id="6205.A0A0R3XAA4"/>
    <dbReference type="WBParaSite" id="TTAC_0001048101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001048101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001048101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001048101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19642" checksum="F44F872389FCF723" modified="2016-01-20" version="1">MEFNPYTLNGGTPNVRMCLTGFHGDVITLVKLLESRIKEFRYQHKKDISLTAFANLVSVCLYSRRFFPFYVSTILAGIDEDGKGAIYSFDPVGSYAREVYRACGTSGAILQPFMDSQIGDPDLTAECVQMEKGPAVRLARDVFISAAERDVYCGDAVVIDVITASGVNRICYPLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAD8</accession>
    <name>A0A0R3XAD8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Importin subunit alpha-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10498</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021769">
        <property type="protein sequence ID" value="VDM35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAD8"/>
    <dbReference type="STRING" id="6205.A0A0R3XAD8"/>
    <dbReference type="WBParaSite" id="TTAC_0001051501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001051501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001051501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001051501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10002" checksum="1A448F5FABBD8830" modified="2016-01-20" version="1">MAGSMLEDVISSIESCGGLNLIEDLQQNVNPSIFKSAYNILEMLYGSNYDETVAAEEEFDAANSGSGNNPPSGDGNEDTFTFAAKTDNMLFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAM0</accession>
    <name>A0A0R3XAM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021890">
        <property type="protein sequence ID" value="VDM35559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAM0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAM0"/>
    <dbReference type="WBParaSite" id="TTAC_0001059701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001059701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001059701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261392at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001059701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16161" checksum="729D31BAE220C23F" modified="2016-01-20" version="1">MNIFCVDNVGMCGNIVEACLNDTFHVFLFDLNMLGGVGNYDYYSQQSQVGGYGSGGGGGGGVTSRGNTTTASTSGNPHLAPPPPHHPGGGGGGGYHPRAYHGGSGGQPPLHPPPPPHHPGPADNQGIRARSFTRGPPNRFFNDYETQFVVKASNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAV5</accession>
    <name>A0A0R3XAV5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5740 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10665</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022015">
        <property type="protein sequence ID" value="VDM35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAV5"/>
    <dbReference type="WBParaSite" id="TTAC_0001068201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001068201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001068201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043801">
        <property type="entry name" value="DUF5740"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19011">
        <property type="entry name" value="DUF5740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5740" evidence="2">
        <location>
            <begin position="117"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001068201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35903" checksum="8427D9D69389C11D" modified="2016-01-20" version="1">MPSSAGAKKSRKAASKVSKKARSKATSEDVDPSALDVGASEGRTTFEEGEMLGDEEGATEYQMAMEGNEIQRQSETIERGNTETEGVEEEVDEEFHRSSLDGPAPTPLLEDGFDGVPQPNDLEVALKMALERLENMPMVDFLQNISKQADVHAQAVSSAKEIANDFVANAADLAEAMQMILQYDQLMLKKLNLTSPYDFGVKPKTVEETRAVMIDRAQKMLDLGQMQYDMSHQISETARPLVDYRFEACDNFNAVHEKISSMKATEESRKLARLAKAARAEVEERAAANAARNDGAEGVEANAEATNPTEEGQPPKDNPNNDANPTSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB52</accession>
    <name>A0A0R3XB52_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10762</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022207">
        <property type="protein sequence ID" value="VDM35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB52"/>
    <dbReference type="STRING" id="6205.A0A0R3XB52"/>
    <dbReference type="WBParaSite" id="TTAC_0001077901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001077901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001077901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036465">
        <property type="term" value="P:synaptic vesicle recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08833">
        <property type="entry name" value="ArfGap_GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047161">
        <property type="entry name" value="GIT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097:SF3">
        <property type="entry name" value="ARF GTPASE-ACTIVATING PROTEIN GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001077901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23715" checksum="79CF4092404DC2CE" modified="2016-01-20" version="1">MESATAVCADCDAKNPQWASINRGVFICDECNSIHRQLGRHVSHVRSHLYKSLWRPSQLFMVQYLALAGANRFWEHVLLEPLLTKRNEKPQPDSPLHPVKADFIRKKYLFHGFFKLPSVIHPDDLNQQLHASVRTAVLETSLYLLALGANPNYIHPMKGTSPVHVACQYEQIGQLELLIAYGGDVCLRSDMGITPLEVGYYFPFAAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBB8</accession>
    <name>A0A0R3XBB8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10828</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022320">
        <property type="protein sequence ID" value="VDM35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBB8"/>
    <dbReference type="WBParaSite" id="TTAC_0001084501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001084501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001084501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6306632at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001084501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21505" checksum="48DB4747BD65B847" modified="2016-01-20" version="1">MIASLNKTVRPTYEKKTNRFSEEAKGFDEEEKEEGEIDPNIDDVDTMQNEELWNSQDYDGRQSHYADVLSCCNGVLRVDNDGETFDFEAKESNNGHSSLKRRSAFHKAEQGVNDSTKEAEDDIDFDDIEGNEENKGTVDEDQENLEDLEGTIVKDHNSSDNANDIGEDKRRRGSDEDADDVDDGEKDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCA7</accession>
    <name>A0A0R3XCA7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11167</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023110">
        <property type="protein sequence ID" value="VDM36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCA7"/>
    <dbReference type="WBParaSite" id="TTAC_0001118401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001118401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001118401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9950633at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026703">
        <property type="entry name" value="ERICH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001118401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14007" checksum="B01D5403F88F0ABF" modified="2016-01-20" version="1">MSGSGDNGCVQQESEGQHSGASNELLLEFLDSVMFKRFDAALMLCQKIIEAEPDNYEARAFLPMLEEANALKSSGYFNPLDVSSSTDSGDSSGEESEHKKERHDSSSSSDEWDYSTTTSDSDNASDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCJ6</accession>
    <name>A0A0R3XCJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11256</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023394">
        <property type="protein sequence ID" value="VDM36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0001127301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001127301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001127301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6019958at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001127301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13650" checksum="D6BBB0A222D12629" modified="2016-01-20" version="1">MRLTFLLSGRFIPYKRVPGSLWAGKQRKIPRLTASRKAAFMDELLLAQQNERYLSKPFIGQEAEATTLPAEQAKELAKENETFYRIYEAKFRTRFPNRRLEHFWSHLNVTKKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCU9</accession>
    <name>A0A0R3XCU9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dynein, axonemal, light intermediate chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11359</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023772">
        <property type="protein sequence ID" value="VDM36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCU9"/>
    <dbReference type="STRING" id="6205.A0A0R3XCU9"/>
    <dbReference type="WBParaSite" id="TTAC_0001137601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001137601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001137601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001137601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19753" checksum="30E78C824CE62208" modified="2016-01-20" version="1">MSVLDTGPVPSTGIKPCSSSPCDTKNTKQTDEILNSILPPREWTDNNQLWIQQVSSTPATRLDVVNLQEELDRRLQQRQARETGICPIRRELYSQVFDELIRQVTINCTERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGRAELDKRVSFWHLYRNLIEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDE3</accession>
    <name>A0A158RDE3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maspardin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000043">
        <property type="protein sequence ID" value="VDM16508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDE3"/>
    <dbReference type="STRING" id="6205.A0A158RDE3"/>
    <dbReference type="WBParaSite" id="TTAC_0000047901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000047901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000047901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000047901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38423" checksum="FC6935CB6E89AFE5" modified="2016-06-08" version="1">MEKSDVFDYEKFKESSFKSIDYPETYNARAFCDVLLKLLDELHVVAVHLVGSSLGGFLAQKFYELSGKPSACVKSLILCNTFIDTYSFESRFSFWMLPVSMLRMTFEYPSVPTDADEYIKTSVDLAKQQTFKMSQSELASRLTMACTTDKVAVEKLRDADITIVEVSFETLASSHFCSIQLKTDLFIRQESVTYKEQDAVVILGTHLDTVPRQATIGFLVVLHEGTENRKRFMLKEVVKQGSVGLLFIPNTVAPVIRYRIMVCPFTPVQVGDLDTTYKRLYEGVHRAYPEAKVASIDTGGHFPFLSRHDEFAAYMRMHFEPYMNTPFFPAFLEDGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDP6</accession>
    <name>A0A158RDP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Golgin-84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1217</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000220">
        <property type="protein sequence ID" value="VDM17640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDP6"/>
    <dbReference type="STRING" id="6205.A0A158RDP6"/>
    <dbReference type="WBParaSite" id="TTAC_0000121601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000121601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000121601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6233681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000121601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="649" mass="72335" checksum="5EBC327D677831DC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDU3</accession>
    <name>A0A158RDU3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6077</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDU3"/>
    <dbReference type="WBParaSite" id="TTAC_0000609201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000609201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000609201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043136029" evidence="11">
        <location>
            <begin position="25"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="307"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="488"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="632"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="756"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="945"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1301"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1406"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1409"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1424"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000609201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1477" mass="161562" checksum="77EC3726EAA57C4C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDZ5</accession>
    <name>A0A158RDZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KASH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6359</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000637401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000637401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000637401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259136at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043136024" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000637401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127313" checksum="18653E8C94D3D73A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE50</accession>
    <name>A0A158RE50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6624</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE50"/>
    <dbReference type="STRING" id="6205.A0A158RE50"/>
    <dbReference type="WBParaSite" id="TTAC_0000663901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000663901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000663901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000663901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117971" checksum="ED27BDD44E1E22A0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REN7</accession>
    <name>A0A158REN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7678</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020394">
        <property type="protein sequence ID" value="VDM32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REN7"/>
    <dbReference type="STRING" id="6205.A0A158REN7"/>
    <dbReference type="WBParaSite" id="TTAC_0000769301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000769301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000769301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="10">
        <location>
            <begin position="345"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1066"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000769301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126920" checksum="1FB9A23DA4FA5407" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REQ6</accession>
    <name>A0A158REQ6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7816</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020408">
        <property type="protein sequence ID" value="VDM32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REQ6"/>
    <dbReference type="STRING" id="6205.A0A158REQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000783101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000783101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000783101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000004">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
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    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
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    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
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    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
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    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
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    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PORPHBDMNASE"/>
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    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000783101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78401" checksum="B33C3C238519B0E9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RER7</accession>
    <name>A0A158RER7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nipped-B protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7888</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020417">
        <property type="protein sequence ID" value="VDM32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RER7"/>
    <dbReference type="WBParaSite" id="TTAC_0000790301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000790301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000790301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="2432"/>
            <end position="2675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1519"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1716"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2903"/>
            <end position="3149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3164"/>
            <end position="3188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1519"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2935"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2970"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2983"/>
            <end position="2994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3035"/>
            <end position="3052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3074"/>
            <end position="3083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3100"/>
            <end position="3123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000790301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3188" mass="345991" checksum="721AE02A08DCC8E8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REX2</accession>
    <name>A0A158REX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SRCR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8256</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020473">
        <property type="protein sequence ID" value="VDM32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REX2"/>
    <dbReference type="STRING" id="6205.A0A158REX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000827101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000827101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000827101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRCR" evidence="3">
        <location>
            <begin position="114"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="251"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000827101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="55978" checksum="C47B25A4C179BD39" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EE48</accession>
    <name>A0A3P7EE48_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001429">
        <property type="protein sequence ID" value="VDM20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EE48"/>
    <dbReference type="OrthoDB" id="6270392at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="541" mass="59848" checksum="67DFB7AF8B829FE6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EEQ8</accession>
    <name>A0A3P7EEQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001546">
        <property type="protein sequence ID" value="VDM21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EEQ8"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="167" mass="16452" checksum="C069492D84FC23F1" modified="2019-02-13" version="1">MPGNVLKRLQKCVEWEPPGLDSRLHILLRSASVLTDNGRSGTSGGVGVGVGGGGRAGSTAGVGGSESSPCLSSARGVDVNLCSANSINGCTHTEGACAGHSLGSSGGCGGGSGGCGGGTALSEGCGCTAVGSGGFLSNRLVRWLKKQIFVLGRNEDQHSTATHIFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EHV3</accession>
    <name>A0A3P7EHV3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EHV3"/>
    <dbReference type="OrthoDB" id="10055895at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF16">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="972" mass="109491" checksum="B7920CA79C78E6DB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ELZ0</accession>
    <name>A0A3P7ELZ0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003612">
        <property type="protein sequence ID" value="VDM24120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ELZ0"/>
    <dbReference type="OrthoDB" id="1063785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="159" mass="17858" checksum="89EF263F4D00780F" modified="2019-02-13" version="1">MNYGLFNSSRLHFSSMHVVIPMFRVQTEVDLCKALPFLGMNNPFDSDRADFSGISDVDNLHIDSGKESAYLQVSRSGIRLFSVGTLCLGTDRHQFRHPDLFEVPNLEEPGEMEAKDIHSFVVNQPFTVILIDRESDCVLYQARIKVPEPVSGSKLPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EPT5</accession>
    <name>A0A3P7EPT5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004708">
        <property type="protein sequence ID" value="VDM25141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EPT5"/>
    <dbReference type="OrthoDB" id="6260248at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="468" mass="51550" checksum="A76AFCDB0167F887" modified="2019-02-13" version="1">MIETSGDCGIPTNTSVDEESDTLQSLLARASPHSLGSQRIDGTSVERAVPALNVAFPVMHTYNLQLTDTIPVQLGEVESGGEECRDLLRPSVRLLCSIGRSLVAEQYRRQMPERMRLRGVKAPKMTEEGRKEEREYLHQTLPPTGVAAASLRWRPKDLGGVYACTCVKAGCSFQPDSFLSLCRHVEEGHYRLRRLRQLPEKSWHCSRSPSVYYPVNPANTKSLGSHGKNIYLCGMCGLCFSTVKAIQAHYAGSHEKRRFDSAETCVWIMCPYCGESMERESSRLPVCRVELRGRPMEVVWNEIRQCTRGDPARATSVHVLASLLLFPNAQSPLCFTTSVARGIWSRSGGGYEGLKERLGNAISAIRGVLRFTGKRRYRRVVEEAVDLRDLDTSGWTAPCEESGPECAIPVARKGARVIVKSLPANVSTVEVEGVSPVPLTSSTASGESCQPARKVIIVGKRVVESGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERI0</accession>
    <name>A0A3P7ERI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005670">
        <property type="protein sequence ID" value="VDM25880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERI0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="65" mass="7610" checksum="BD39A5B34CBEE3EE" modified="2019-02-13" version="1">MEELLASALEKVEAEIEENERKADEKEYEDFVMQVETSVCTDLIHQFYNVNRYYSPGAWLTATEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EV77</accession>
    <name>A0A3P7EV77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001226">
        <property type="protein sequence ID" value="VDM20504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EV77"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="5">
        <location>
            <begin position="98"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Importin-7/11-like TPR repeats" evidence="6">
        <location>
            <begin position="583"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="817"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="989" mass="112261" checksum="E8436FA80C449ADF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F8C9</accession>
    <name>A0A3P7F8C9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004331">
        <property type="protein sequence ID" value="VDM24859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F8C9"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="53" mass="5808" checksum="9D5E08287755A59E" modified="2019-02-13" version="1">MSGNGTVCSNCKTSQTSLWRRAPEGDVVCNACGLYRKMHGVSFSPSPKLRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F8N0</accession>
    <name>A0A3P7F8N0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020409">
        <property type="protein sequence ID" value="VDM32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F8N0"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="8">
        <location>
            <begin position="579"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="9">
        <location>
            <begin position="698"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130972" checksum="D248F9389B6E7C2D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQ10</accession>
    <name>A0A3P7FQ10_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022148">
        <property type="protein sequence ID" value="VDM35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="521" mass="58324" checksum="4C2D35D4FB871B0B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G7X3</accession>
    <name>A0A3P7G7X3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023769">
        <property type="protein sequence ID" value="VDM36337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G7X3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="41" mass="4272" checksum="D141C35AB1796A36" modified="2019-02-13" version="1">MDRAALIFPASTTTLAQTPASVFTTVVVVALATVSTARRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G822</accession>
    <name>A0A3P7G822_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000760">
        <property type="protein sequence ID" value="VDM18928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G822"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="298" mass="32105" checksum="1CB282C12D415016" modified="2019-02-13" version="1">MCSCDGLGVKRSPVKKLLQKKSVFDSSEDEIDDDNANNGESDVSEFEPFKRGSFDGPAASLAERIRSQPPRRTAAASTIKYNFDDSGGDEVGSNSCEEEVFTAVDHGQGDETINLNSPVKQTVSSAISQSQTDANEKSKGDAAAWPISYKESATAVTKRSSARSGRAGSSRRGHSVRGGAVQRGGAKNAGSASTKRITEETRSDASGGESNKNDEADDIFVPDSPVPPSRAKATRNAQRKMRYFFDSDSDEVVEVSSDSEKDADSAEDSNVRRKGRVAVRSRKRKRLNSDSDEDYVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GBF0</accession>
    <name>A0A3P7GBF0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDK-activating kinase assembly factor MAT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CDK7/cyclin-H assembly factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Menage a trois</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">RING finger protein MAT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000999">
        <property type="protein sequence ID" value="VDM19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GBF0"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16517">
        <property type="entry name" value="RING-HC_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="469" mass="51930" checksum="C7383B2AA882B9E4" modified="2019-02-13" version="1">MEVISLNSVFCALRELCLVMEPDLQTCPSCKTSKYNNPQLRLMVNVCGHSLCENCVEVLFVRGSGLCVQCKTPIRKTNFRYQLFEDPTVQKEVDIRKKVLAEFNKREEDFENVEDYDSYLETIEDIIYNLSNDVDVDKTKKFIEQYKKDNKDIIKRNRKKQSNCAEFYERELEQERILRERRAEVQAADEVADLQRRKRLHAGRTLQGFLCGAAAVPLPEEPQPKIELHSNPPTSEHPIPSTVPPSAVLESKHRFLPPPSVALFQRSVPLSAASRWSGVPLTPASSMVDISQLLPPPPLAASSWATSVEHHSVVIPTSITRSGGQTDTVVLSRPHGVKSSSSFSSSVKATTGATRNLDEWLQPYRPELCGPHPPSPSNGPQWGALEAVYLEAVIEPTTKDVDAAADAERGDLFRESDNADEGVAGGSAGVEDGHTRRGLSHALPRGACGIPPSCYLTRALQESRCGLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GRI8</accession>
    <name>A0A3P7GRI8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003943">
        <property type="protein sequence ID" value="VDM24455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GRI8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="37" mass="4592" checksum="5BA2CC70F3EBD045" modified="2019-02-13" version="1">MSPSARVMMTMNVWRSVDVNVFWWWMRKKRSVYVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GUY6</accession>
    <name>A0A3P7GUY6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005415">
        <property type="protein sequence ID" value="VDM25705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GUY6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="96" mass="11149" checksum="14B77B9EEE06D0B4" modified="2019-02-13" version="1">MSNTRRVSSVHRTHQEYSYLDCFYCSCCFPLQYNVGRLGGAFPNQHTALLECPLWPFTGQSLLCLLLGSCHPFCGYCWFHCWCSVWRGHGCCTLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GYM1</accession>
    <name>A0A3P7GYM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007674">
        <property type="protein sequence ID" value="VDM27065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GYM1"/>
    <dbReference type="OrthoDB" id="6273170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="86" mass="9651" checksum="15C878D8F102AF0F" modified="2019-02-13" version="1">MDEELAKVFKATLLEVTSSKPSDVKDTKVWATALVVAYLRVHLSSRKEEWEMVVRKAVEWLEGSGVNAEAVIEKARVALEKLLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H1K6</accession>
    <name>A0A3P7H1K6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009864">
        <property type="protein sequence ID" value="VDM28022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H1K6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="72" mass="8488" checksum="F610BC12A4CE30AB" modified="2019-02-13" version="1">MVPYYRQILPTFNLFANCNKNIGDAIEYSQRKNENIGDLINETLRIMETKGGKYAYFNIKYMIPVYESNLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHY3</accession>
    <name>A0A0R3WHY3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS176</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000011">
        <property type="protein sequence ID" value="VDM16023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHY3"/>
    <dbReference type="STRING" id="6205.A0A0R3WHY3"/>
    <dbReference type="WBParaSite" id="TTAC_0000017501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000017501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000017501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515366at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF19">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000017501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39895" checksum="9A658F9A33D9EA6A" modified="2016-01-20" version="1">MDPRYDSALIGILQNEGSLEKYLEVMFGFLMRRTDFYYELETGKKLGFPPGHALEMVIKAFNKYHTIFRRYQEAQMRKVSSAPEAIPSGRVIVFKVLQLVAQMLSDDSETIKHQKSSAGTVQTSVVGLNDKASRPESKIGKPTCGSYFKKDDNGERIYEADPDCYNGARRDMYSWSQKILEIDIHVKIPERIKTARQLNVKVDRRHILIEEKGSAEPIIDLDLLKDIKTESAQWSFEVNEHLLTLSLDKVEEYWWEAAFVGEEKINVQEIDCSRPIHELDDEAQGKIAQLLFDQEQKRRGLPTTEEQRIQDILKDAWNKDGSPFKGQPFDPSRISVESSAQLPTRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHZ5</accession>
    <name>A0A0R3WHZ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-pyruvoyl tetrahydrobiopterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS190</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01000012">
        <property type="protein sequence ID" value="VDM16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WHZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000018901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000018901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000018901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14045at2759"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022469">
        <property type="entry name" value="PTPS_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00988">
        <property type="entry name" value="PTPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000018901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16125" checksum="A63F39CD6B23FEC7" modified="2016-01-20" version="1">MNPRVYVTRVETFSAAHRLFNTRLDEEENIRIFGKCAGENGHGHNFKIEVTVLGEVNPITGMVLNSSELRHIIQTNVLNIIDHKNLDLDVKYFREANLVSTSENIVIFIWKCLRSAIDPKLTLEVKLYETESNIFCYRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ33</accession>
    <name>A0A0R3WJ33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000075">
        <property type="protein sequence ID" value="VDM16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ33"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ33"/>
    <dbReference type="WBParaSite" id="TTAC_0000065901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000065901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000065901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000065901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34293" checksum="8130EFA97279FA9F" modified="2016-01-20" version="1">MIRRKSLFTGQKSLTAPRLDATATFTVYTRDRRMKYVVPSVFASQSFNQFRNRRLLDVSTFVKKVTEKINSKAAKIPDSNSNFPAAIRLVIISLVCELKRHPKMHFDGREIAIILQMYYAIVGYKVRLMTQIEFVDFLVGSLGITNSHTLAGIKRVTVQLRDDRRRPEKLGIPPGNFVIMLSIYLRGSLLERAELAFEIMDIDRDGLLRKQVEFRRFLAGSFDPEIAATHADIDPDQPVRETIQYLENLLASSSDRGVDLIRFKEMVVKQPWIIDCLLPISCRELHSMAFQNLLTVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ47</accession>
    <name>A0A0R3WJ47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cas1_AcylT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS674</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000076">
        <property type="protein sequence ID" value="VDM16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ47"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ47"/>
    <dbReference type="WBParaSite" id="TTAC_0000067301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000067301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000067301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000067301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25855" checksum="ABB9C23705EC4050" modified="2016-01-20" version="1">KYQSAIDRLNPYTKTRWCITFAFFALYAFRIYSIQVSGLWFPNYKGFHIISYALAIYILSLFIHSISPQVDPEFADMLGTVAKMKHRHFQERRPMNFGPLFHDYWRRSFGNSVFVCHNVTHAPLTFAFCLKFVLCHTSNNHKSSVHLLSFSRYSGLLANSRGVFHPSFHRYDEKADKGMLFLFTYIRAFAFAYWFMSGLPRGHFRSAVLIVKSTWFCCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJH9</accession>
    <name>A0A0R3WJH9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1681 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS829</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NECAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000107">
        <property type="protein sequence ID" value="VDM17047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJH9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJH9"/>
    <dbReference type="WBParaSite" id="TTAC_0000082801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000082801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000082801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="3">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000082801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="29748" checksum="5803DB587BFB1A50" modified="2016-01-20" version="1">MVDSDYESVLLVKREVFLYTLPPRQSTRGYRAAEWSLDAPTWTGRLRVVTGSGSSDSVLYIRLEDAVSGRLYAQCPVEAFPSVAVEQVLDSSRYFVIRLVSDDGRTVFVGIGFAERSDAFDLNVAIQDHFKHCKQAAEAEKFQLESASDQNLPKLDLGLKEGQRLRLNLNTRRSGDAGEGSGGSGSSRTRPLPSLKLGIPTGVPGLIPPPPPPAGGGRNRQNLRGTVAEASVPAPVPRSTTQTSSNVDLLAGLFQSAPATTSKVPVNAQNPNDFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJT9</accession>
    <name>A0A0R3WJT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000141">
        <property type="protein sequence ID" value="VDM17230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000095601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000095601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000095601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000095601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30723" checksum="CE17F20C2D834F9B" modified="2016-01-20" version="1">MRDTQRGVNASPVFVCAKFTPHRHNFASYTTSPFPPTPSLLHSLEVVFSPLLTHVVHPAPSSHETPPFLFLFLSSSAFQTPTGSIQENEELPQVLQFAVPSSQRVRTFPPHLLNQETIFILDWAKRQCQVHESETSIIPCKEAAPCGIRHHNQPMAADAVSGQLTSERSPCVSLSALFTWWSRVRGFDHGDCPKVVIVLVCDECLAISVTVMPAVETRSTLVSSQSRCKTNLARVRYSVLLLLGCQSMSDKLDVFTASLLTGVKGDRGDWKHESGGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKA4</accession>
    <name>A0A0R3WKA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1141</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000194">
        <property type="protein sequence ID" value="VDM17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000114001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000114001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000114001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274713at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000114001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17917" checksum="F78C736458049353" modified="2016-01-20" version="1">MDEESKQSVGIFVFLIFVLVGHVACWIASAVKAVIDRKARRRKAKASKDGALLAEARPKELEDEEEQSNVEPTKVGNGGPKFAISRPQLNSTSTGRANGEHHFPKCPKRLLSAGNAKRVSPEELAIMLDSYAIQKPEVQQVDSAARSPARPTAKGMPTSNVGTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKE8</accession>
    <name>A0A0R3WKE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000207">
        <property type="protein sequence ID" value="VDM17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WKE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000118601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000118601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000118601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155648at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000118601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33704" checksum="7C85E07BCB6E5491" modified="2016-06-08" version="2">MTALMLMEKGKEVRSSPLPPHYNWSYVSSETIQLSWDVHRLAHLKLEQLKLIVLPERAEGKYETFDFQLGKAEINDLVPGTVYSVFFEPLRKGKASFLFSGALETLPAESATEKIVPVPQLYWHRRSHNSFQLVWKAEELINHGVDQIKVAAQPTTSRDSPKLSTAATADGALILDELVPSQQYEVMMEVIKENIPIFYQLVYLETRSTAQEVSTIPVDGQNPAECAKASDLSPPIWTLPSIEPTAVTTPTSGFQQPHLIGPPLMYTKSRLKMLLTTVWVKARQERMDCCVSTANTVKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKI8</accession>
    <name>A0A0R3WKI8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1230</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000226">
        <property type="protein sequence ID" value="VDM17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKI8"/>
    <dbReference type="WBParaSite" id="TTAC_0000122901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000122901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000122901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261822at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132900" evidence="2">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000122901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16156" checksum="ADABC8B742E7C3FC" modified="2016-01-20" version="1">MIIRKLTVFLLALCVATLIAALCLNDWHCGSLFEHCTAEGAEDRDAMLAVMTMLVIGVVFIFIVFLLDVVLLCRKTTATGLITARFVFIYLGAALAFIAVIVYTAIKSNMWGYFLAVFASTISIVLAMMAVVSSRCVSQSEVVTVHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKV0</accession>
    <name>A0A0R3WKV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NYAP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1355</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000275">
        <property type="protein sequence ID" value="VDM17861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WKV0"/>
    <dbReference type="WBParaSite" id="TTAC_0000136801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000136801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000136801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273320at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000136801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="35738" checksum="A6A5AB0B4CBBCD94" modified="2016-01-20" version="1">MEQGFEKRRVLRRSSAQFYVTAEEHIKNEMKHERHLTETSRLTSSWANLRLTGTDKPEYSDCGFSSPGSSGSSPVGHRPNSFSGPLVISVTCSSGGGISNTNASESRSSVAIATAPGIVSFSRSASCYPSPVASPVSSRVQCYSPSIGLPSSFAAKKRTASVSSGSSASPLIFGKNRGKKRTYKCLRNNDMVSSAEASRESSPESPRTFCRSGKILRSSEGAVNHHNVLSHLGSPRDSSQCTPPVSTPSSPILPVPFSMRMGCNCPSTTSLPSLAHSTSSAMQSCFHRLPVLPSQPPDFTPSELKPRSPSSLSCPESAVACQIVSKCPEGSSERGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL35</accession>
    <name>A0A0R3WL35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1456</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000323">
        <property type="protein sequence ID" value="VDM18037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL35"/>
    <dbReference type="WBParaSite" id="TTAC_0000146901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000146901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000146901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269303at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000146901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37314" checksum="D857C59171DCB90C" modified="2016-01-20" version="1">MSAYRIHFDYPTKVETARMNNKARSLFVRLTFPDLHKPSPKPRRSKGCCGCRCSCTTSPPSPDDHEPIWSNLIKPPPKSSSSKSTASNAPANWTSVQPSQKPENGDIWIRVASNRVSLMLILCGPSPLTQRVDSRASNTHQESLKSLSISDLREQEEETYSDQFPTVYYYWDSGRLSKKLDPLRSSMAVAETCVCLMLAPATRGEGWSDDDLKMVHKSVRASTPPVPKRRTVEKRDFCWQESVKETEGVSSKNFVIVDCDNGIELPSKSPEIGDVESNDFIEVEEDRLASNSTRTCKCKGVPQEKKMQEMISKLNPCREFFTHTSSLIPVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL92</accession>
    <name>A0A0R3WL92_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piezo-type mechanosensitive ion channel component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1517</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000355">
        <property type="protein sequence ID" value="VDM18137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL92"/>
    <dbReference type="STRING" id="6205.A0A0R3WL92"/>
    <dbReference type="WBParaSite" id="TTAC_0000153001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000153001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000153001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="3">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="3">
        <location>
            <begin position="397"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000153001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="643" mass="71653" checksum="A8A6AE5479AEA6B7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLI0</accession>
    <name>A0A0R3WLI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4332 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1605</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000400">
        <property type="protein sequence ID" value="VDM18276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WLI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000161801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33509" checksum="EDFDC286C2D10A69" modified="2016-01-20" version="1">MSNWSEIRNLAEKLRSVQSAGSTHYLSERICVDIVSYLINSGRLRLIRSVDGRAFLTENELFKEIVEELAAHRGRVSLLELSKSLEMECSIIELHVSKLLSNHCEYLDDQCLLIAGELMTKSFVRRITEEIRDRLEFRGVMSMIDLVRIYNFAPQFLASIISDHSGVLFDVSRDGDKLYTNLYLDKQESKILGYLSAVITPTSLIDCGSKLDIPPKVLSRLTGTLISVGKLKGALTAGKSIYTPLCYRKAQDAFVSDFVKQNGYVDWAIVQRVGIPDPSSYLRSRFPSAIHTKGFAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLI2</accession>
    <name>A0A0R3WLI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TSNAXIP1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1607</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000400">
        <property type="protein sequence ID" value="VDM18278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLI2"/>
    <dbReference type="STRING" id="6205.A0A0R3WLI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000162001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000162001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000162001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="264"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000162001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52611" checksum="5066C33D75CF0EA9" modified="2016-01-20" version="1">MFLRLNSKSGNFADRALSIDPWPAHATERVNTETQILRDGNRLIAQSKEQSKLKPPPKPRFLVLLENKIMRDTKKLGISEETSDPLRLQLYREIFDRFIEECAYYAPILAKIKDQYEGFIMHLRREIKEMQPIKARELLIAQHYLCLRGKSSYGLPLLMPINVSTNFKVGKMRVTCCPTQLPQIPLEIDFLKFERNHDKYKLDKLRQECVELQVTVRAALSRFFEMGNVHGYLLKLLLCHLEVAKLMEQLRAREGTCNLEADGRKLLVAEVNDINSRLRELEALTRADMDRNIDDPVKLKVLVGEYEKALESANTELNAYRSDFEERVPRVKYDETKKQLEAKIREVNSLNEELESAASRYRYFAGLLSQIVNVQMFDLFAMYSGFVFNFCRSDPAQKVEYINALLFKYRKIAREKTAEQLADFVVHDLAKAEAGGLPSVNRPTVGKNRPKPEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLV9</accession>
    <name>A0A0R3WLV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloride intracellular channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1734</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000478">
        <property type="protein sequence ID" value="VDM18462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLV9"/>
    <dbReference type="STRING" id="6205.A0A0R3WLV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000174701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000174701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000174701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053823">
        <property type="entry name" value="CLIC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920:SF5">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22441">
        <property type="entry name" value="CLIC-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CLIC N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000174701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34274" checksum="4FB47DE26B1B5EE6" modified="2016-01-20" version="1">MKQPMVELFVKASTVDLGDKGACPFSQKWFMVFYMFVERHLINLRVIPVSMANPPNEYSRLDMGKQLPAIAFYSTPSDDENALDTPDYVLAGNDELEEFIRSKYSSEMNIDAEEQWIGADLLRSLNHFLRTGSSQQVLANLSAVNDHLLKMKTTFLEGNTFSYSDCVLTCKLHHVRIAASFFRGLDIPNEFTYLWSYLKAVYATRVFDVTCPLDRDILLHYLEKVDFLSLEARNEAHHEIILLPQDNKSTFIPSENPQAAAQMPHLMCSGVRLVVHSVMPSMEYDRTMPARLSRLFTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMJ7</accession>
    <name>A0A0R3WMJ7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat and WD repeat-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Origin recognition complex-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS1972</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRWD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000647">
        <property type="protein sequence ID" value="VDM18712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WMJ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000198501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000198501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000198501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052489">
        <property type="entry name" value="LRWD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056160">
        <property type="entry name" value="WD_LRWD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24370:SF10">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24370">
        <property type="entry name" value="OPTICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23215">
        <property type="entry name" value="WD_LRWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0137">Centromere</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NAB co-repressor" evidence="17">
        <location>
            <begin position="433"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="17">
        <location>
            <begin position="754"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat and WD repeat-containing protein 1 WD" evidence="18">
        <location>
            <begin position="1616"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1105"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1261"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1367"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1482"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1132"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1162"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1277"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM18712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000198501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1997" mass="216811" checksum="08045B2E9BE7D1C6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNM1</accession>
    <name>A0A0R3WNM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2346</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000986">
        <property type="protein sequence ID" value="VDM19736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNM1"/>
    <dbReference type="STRING" id="6205.A0A0R3WNM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000235901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000235901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000235901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="419"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="682"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM19736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000235901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="914" mass="103294" checksum="771E0A417A0E0D29" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNM2</accession>
    <name>A0A0R3WNM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2347</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000986">
        <property type="protein sequence ID" value="VDM19737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNM2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000236001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000236001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000236001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000236001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15187" checksum="5D2655814F2A61BB" modified="2016-01-20" version="1">MVHWLGAIIVREDTQAGTPVKQEEVEGLGKVRVILYRDGVSEGQFDSVLQIELSAMQRACSNLRPDYEPRITFIVVQKRHHIRLNPVEEGRNVSPGTVVDTEITHHREFDFYLCSQEGIQTRQRWWWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNZ4</accession>
    <name>A0A0R3WNZ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWI/SNF-like complex subunit BAF250 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001116">
        <property type="protein sequence ID" value="VDM20129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNZ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000248201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="627" mass="70441" checksum="5E0A4D81574E2FC7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP87</accession>
    <name>A0A0R3WP87_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2562</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001215">
        <property type="protein sequence ID" value="VDM20481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP87"/>
    <dbReference type="WBParaSite" id="TTAC_0000257701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000257701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000257701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000257701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21588" checksum="6FCE6C2D1D4A244E" modified="2016-01-20" version="1">MELAVSPQRFSAFAITTCDTAAVEFTIEAIRFCASTVISILTQREGDLIDLTDPVAAQPFLPLVWATAISMRAEKDGYIRNPHALVNLIQCAVLPHRLQPPGDNLPRQWRVRIGEEEGEEEEKDTDHTDDASGGGGGGGGGGGEGVINGFRESLLKLFLMDKVCVPLVYTQVSSELVFVLMLVLSLVGVFSFPTPPPFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPI8</accession>
    <name>A0A0R3WPI8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Poly(A) polymerase</fullName>
            <ecNumber evidence="12">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS2663</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01001344">
        <property type="protein sequence ID" value="VDM20814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPI8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPI8"/>
    <dbReference type="WBParaSite" id="TTAC_0000267801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000267801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000267801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="217"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="542"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM20814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000267801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="76129" checksum="B247DA87D35C8C64" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN8</accession>
    <name>A0A0R3WPN8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2713</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001419">
        <property type="protein sequence ID" value="VDM20965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN8"/>
    <dbReference type="WBParaSite" id="TTAC_0000272801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="611"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM20965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="784" mass="85100" checksum="563AFB8A785A4FD4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPX6</accession>
    <name>A0A0R3WPX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2803</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001524">
        <property type="protein sequence ID" value="VDM21202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000281601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000281601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000281601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6225235at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000281601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10236" checksum="D2B7E1A70FB3E80E" modified="2016-01-20" version="1">MSNSDRLDWKLNDFDMGIKDIVIEALSIYKDKLRIAQHIKESADHLYGGPHHCIVGRNFVGYGTQEKWMQCRKGDLKIYLYKSPRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ24</accession>
    <name>A0A0R3WQ24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2849</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001586">
        <property type="protein sequence ID" value="VDM21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ24"/>
    <dbReference type="WBParaSite" id="TTAC_0000286401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000286401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000286401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027960">
        <property type="entry name" value="DUF4519"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644:SF2">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15012">
        <property type="entry name" value="DUF4519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000286401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8915" checksum="0B00136CFBF1F6C4" modified="2016-01-20" version="1">MRKLRGGTSKETKKDKLEKRKDKETINEQVYKLVLPTVGALTLLLVVVVGEHLGYVRHRCQKFKALAPPEAAHISGDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQR9</accession>
    <name>A0A0R3WQR9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3094</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001916">
        <property type="protein sequence ID" value="VDM21941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQR9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQR9"/>
    <dbReference type="WBParaSite" id="TTAC_0000310901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000310901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000310901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247219at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="126"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000310901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38330" checksum="F9E02967843B1251" modified="2016-01-20" version="1">MRRRKSAKSGSFFSIASTKCLSYVHSPTFLLVCLCCGAYLILPSMAQEVVSDCVIHRPSSAKGNYTPPAVIRKAFGRIKQRCDLANRDREIRAANVTNPGYLKGRIPIVKFGVQLATDGRDSIAQMLPAIDLAIEKVSTMPAYRGVVFRVVPILYFDWLACDSLAILEKFNRREVNVIFGPINDFVLGAAARFSTALYLVPIVSPAASSVQLADKNEFGMLTRMYFTYADLEWVIASTLIHFGWKPKLSTPIAMITVQPITISDAFNAGWDSFFQQQAISTVLVNYKHHRYHVERGADEIKNIFKELPKVARSKLNQIFVYLSLVPSPIDHAASAQPSHQPITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS50</accession>
    <name>A0A0R3WS50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAB3GAP2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3575</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002665">
        <property type="protein sequence ID" value="VDM22904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS50"/>
    <dbReference type="STRING" id="6205.A0A0R3WS50"/>
    <dbReference type="WBParaSite" id="TTAC_0000359001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000359001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000359001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000359001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="738" mass="80008" checksum="0286A14BE9CB663D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSQ8</accession>
    <name>A0A0R3WSQ8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3783</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01003042">
        <property type="protein sequence ID" value="VDM23356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000379801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000379801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000379801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69989at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133023" description="Membrane-bound transcription factor site-2 protease" evidence="11">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="12">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM23356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000379801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17788" checksum="CC700EFDEBEF035D" modified="2016-01-20" version="1">MPGVNLPMSQLGFYLLTLLVCVVLHEAGHALAALRERVRIHGFGFFLIGIYPGAYVDISDSDLNSLSPMRQLKIYSAGVWHNGVIVVMSIICFYALPWILSPVYIVNQGVGIVHLQKVLLEILYRNTVLKPTVVIISVRRYSSGDGRYLVSNPFRSLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSW8</accession>
    <name>A0A0R3WSW8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LSDAT_euk domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3843</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003138">
        <property type="protein sequence ID" value="VDM23537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSW8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSW8"/>
    <dbReference type="WBParaSite" id="TTAC_0000385801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000385801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000385801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="8">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="9">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM23537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000385801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47059" checksum="71FBCF65ABBB4534" modified="2016-01-20" version="1">MRIAESTSTEKLQTLLFDLWQMPKPGLVLTFYGSDPQSPSLHKLLQKSLARVTRHTRTWILTDGREKCVGDAISKAVRGYAEAYGMQQLQVIALVPWRQLYNSHLLRCEDYLGVTQMAFPKKPPGNDNRIQVAENHTHYIFIDSPDSWKDLTLCRTQFEAYVSHLNDLTNEVNRVPVCGVLIEGDRSNLLGLSFALRLNIPFIVISDTGGLAKALEMFVNFMKQLMQDENDGAFHLRWSNCKYSLTSLIERVKGVAHFESSDEAYLTDILDRAYLLEFITTTSEGANEMDTQLFEGIDEEDSWDYKIRIALSLNRTDFLPENMFSRVHWQAKKGMKEVLTKCLMGNSANFIQLLVDSGFPLHEYVDETLLVQLYRSDFESSLPASHFTAGSEGTAIQELCIYINAGERRVVIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTL8</accession>
    <name>A0A0R3WTL8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MKLP1_Arf_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4092</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003647">
        <property type="protein sequence ID" value="VDM24157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTL8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTL8"/>
    <dbReference type="WBParaSite" id="TTAC_0000410801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000410801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000410801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288110at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-like protein Kif23 Arf6-interacting" evidence="3">
        <location>
            <begin position="271"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000410801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42405" checksum="8E8BA43A7917BE53" modified="2016-01-20" version="1">MAAVSSIQALDASLLDSVSSITSSSADIFPLNLCGCFESRKSQRRSSKRARRSPSWIPWHSPNCPLFSALQARFIERDRIRGVLARFSMELESYTNEDFHGSESEDSYLALRDTLDKLKVEKLQLESRNRYLENEITKQEALVLFERTERMREMSGLKAQANKLKAQLDALQTSRTLLRSKRDYHGPPSVASCVGSDGTIDETTSSKHRSKKAAPAPSSKNRVAALSRQWEMRLAAEREQQDVRIGLRSKTPIPRFHTEVALGDAFDRPPAFNPRHRRSRSVGGDHGVWLEHKENRPTPLGTIFSPTSVNVRKSVTRIELDDTLQATNYVLHHQTATPEGNVETRLFKGAIIPTAGGGSAIVFNDVEELRQVSPLGTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU65</accession>
    <name>A0A0R3WU65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004086">
        <property type="protein sequence ID" value="VDM24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU65"/>
    <dbReference type="WBParaSite" id="TTAC_0000430501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000430501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000430501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547746at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000430501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10486" checksum="2166E87A0D0782E0" modified="2016-01-20" version="1">MKKADANLVLNVHATRAAEAVATAPLDPTVAVGQGPLIATADADAIVSEGMGAEVVVTLVARTLRDPIPDRVWIVGEKVKGLTFHVCDICDKPIVVYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU74</accession>
    <name>A0A0R3WU74_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4301</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004111">
        <property type="protein sequence ID" value="VDM24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU74"/>
    <dbReference type="STRING" id="6205.A0A0R3WU74"/>
    <dbReference type="WBParaSite" id="TTAC_0000431401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000431401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000431401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000431401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40784" checksum="1672578D7B6C0712" modified="2016-01-20" version="1">MDAAAAAAAAFRSQAAINDSRASDVMHRYQVAYQQQQQWQQQLQHLQRFLQTATPEQQQQVMMMLFSQIQQQQQRQQQQQQQSLQQPVTSTNRLAQPPPTFHHHHHHHQHQSSMPSSFAPLPPPPAPPSQYRMQNSGDYGQQSQQRPRVPPSSSLASSSSAPSLVSVGKASNSASSTALSNSSPGFHRNASVFLSQQQQQQQHQQQQQQQQQQESQLPPQMQPSAWPPEYYTNFMNFSNSKFPQMTHLTQFFKLYDAPNPAVVAAAIAAAASTVESAPLRHQHLHQQEHQHHLRPGGGSSSSTQPPPALPQPPQSSVPGSVPVRGAMSFQETETLSELLRLIAQHHSPQSTTGHQHHHHHQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUR5</accession>
    <name>A0A0R3WUR5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004586">
        <property type="protein sequence ID" value="VDM25058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUR5"/>
    <dbReference type="WBParaSite" id="TTAC_0000450501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000450501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000450501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000450501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8643" checksum="D8D4D28999D1C05B" modified="2016-01-20" version="1">MGITFQDEASATDCSTWLRRFSTSSISSYLTRHSTSVELAKSARLLAGLPLDGLGFSLCANDSLLGEVVENEEAEDEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV41</accession>
    <name>A0A0R3WV41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4617</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004892">
        <property type="protein sequence ID" value="VDM25294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV41"/>
    <dbReference type="STRING" id="6205.A0A0R3WV41"/>
    <dbReference type="WBParaSite" id="TTAC_0000463101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000463101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000463101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000463101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27349" checksum="5CF215A80833E24F" modified="2016-01-20" version="1">MIFFCTCFFTFRNPNILDACDIDDQTKEMLLQDIRHRLMPQAVKLRADFEVSCFAYEGIDAVRRALHAGLALSTDGLPIKINLIAPPLYVLTTQTLEWNEGLAQLERVLEAIRNSIEEQEGSFKLQQKPRVVSDTEEADFQRQLEELEDANKEVSGDEDDEDEDDGGDEERNEYEIEDEDEDEDEEGEEGQDIAGAAEGGDSVEEDEEQRKSPRSVNNDVKKGKKRVKQRQSNNEVAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVI0</accession>
    <name>A0A0R3WVI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005246">
        <property type="protein sequence ID" value="VDM25585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WVI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000477001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000477001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000477001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000477001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20046" checksum="983DFE7038E983FE" modified="2016-01-20" version="1">MTLKASKTVAERKGTSKREKRPRAYNWDPSSDDYTGPWAKYKDEVTISVPSDEDRAYLEAYLAKKAVKKKRVEEAPMSEEKSTLHISTPTDYQGRSFLHPPHDVPGVSLTTEEPPERCFLPKRLIHEWSNAHARGVSAIRLFPKSGHLLLSAGMDSKVKVCQLSSVVIFVLSHPSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVK3</accession>
    <name>A0A0R3WVK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4777</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005307">
        <property type="protein sequence ID" value="VDM25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000479301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000479301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000479301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000479301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7329" checksum="AD7434488EBD85F3" modified="2016-01-20" version="1">MDDGLREEHEHQSCGGIAEDLRCCRSGLVMLRPSASVSVAVDGQCASSLALANVGRECACTSFIWWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVV1</accession>
    <name>A0A0R3WVV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hist_deacetyl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4877</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005573">
        <property type="protein sequence ID" value="VDM25807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVV1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000489101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000489101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000489101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000489101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15539" checksum="F3E81BF5B000246B" modified="2016-01-20" version="1">MREFFPPPHYLHLIFVVTRVLFISIHRYECRKFWPNLREGDFDFIGDGSGRGFNINIPLNKTGMTDSDYLAIFHTLIMPIAYEFDPEIVLVSSGFDAAIGDAEVGNHLCTNRAKVDVLSFVVVLFRAKCGLVLPATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW50</accession>
    <name>A0A0R3WW50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4975</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005821">
        <property type="protein sequence ID" value="VDM25975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW50"/>
    <dbReference type="WBParaSite" id="TTAC_0000499001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000499001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000499001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000499001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15200" checksum="24735922E30BFEEE" modified="2016-01-20" version="1">MSTKAVTWRMTSRPPRLRPHHHLHNPPLLLLPKIPLLHLLVVLAQHLHSIAPPSFTNNSNKWHAGLVLVLFHREVSLNPPSLLRSHNTEVYHHSSIWCSARVCTDLLRPSNSNSLSSSIGIRRFSMEKVGRVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW55</accession>
    <name>A0A0R3WW55_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4981</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005845">
        <property type="protein sequence ID" value="VDM25987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW55"/>
    <dbReference type="STRING" id="6205.A0A0R3WW55"/>
    <dbReference type="WBParaSite" id="TTAC_0000499501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000499501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000499501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10670706at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000499501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28009" checksum="4226C282EBE74EDE" modified="2016-01-20" version="1">QQKHISLKQVQAYRFKTVTNFGGSYGFSYYLQITNVETGWMIDVAKIIPFPRENDSNSKNLCYSSTFSLDLFSSVLNLPTFASSVPFAECHERPDPACLYFLLHRLESPTEGMRLIAHVCIEASKVPSSLRDQALACRVSLLDVALQSLLHPCLHYIEYLAGFLDPPASLPPDLSIISQDSSNVARRLLLCLYLRRPGILYALKSSEAWSFLRTPSANGSIPECFEQKEVRLLFCFISDGILDDTSALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX27</accession>
    <name>A0A0R3WX27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5302</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006948">
        <property type="protein sequence ID" value="VDM26655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX27"/>
    <dbReference type="STRING" id="6205.A0A0R3WX27"/>
    <dbReference type="WBParaSite" id="TTAC_0000531701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000531701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000531701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM26655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000531701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17818" checksum="260C02A1BB913236" modified="2016-01-20" version="1">VEAGGKADDEINSKSNASKPKQAVTCRTCKGAHFSLQCPFRSEMEALRSFMDSANAAAVQEIAPELNTGRYIPPALRAAAAATNSVPERRRMDGFSIRVTNLPENTSESDLREIFSRFGDVIRIFPAKDKRTQLNRVGTRWKERGLVFFKLTDIGLSGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXC1</accession>
    <name>A0A0R3WXC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5397</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007340">
        <property type="protein sequence ID" value="VDM26888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WXC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000541101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000541101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000541101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000541101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15216" checksum="D91C4EFD684F9C89" modified="2016-01-20" version="1">MAWQRHYQIRQFYTWNDVAQRTEVAYYAAMSRPRITAKDAIVAAYERLGPVCGIIMAIGWMIEWFLIILLEWFKPSNTVGRVPHFLTTPSQLEVWNRMDTSPYGEGETEATPDSGTGEVCCQSTTCHHPHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXS5</accession>
    <name>A0A0R3WXS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear transcription factor Y subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007952">
        <property type="protein sequence ID" value="VDM27210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000556501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000556501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000556501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000556501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11045" checksum="DD897AA0FA1E8B3B" modified="2016-01-20" version="1">MTELMDGQQYQLPGAAALRKPSVMPSSQQQQPVMMQQQQQQTQMISLGQETFVFEPLEGQAIPSTLLEQQTRAPEPFTGSSSQARGATMQEVFVQVNVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXY5</accession>
    <name>A0A0R3WXY5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008207">
        <property type="protein sequence ID" value="VDM27315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXY5"/>
    <dbReference type="WBParaSite" id="TTAC_0000562501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000562501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000562501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263284at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000562501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19962" checksum="08BD6BC89C6279E6" modified="2016-01-20" version="1">MKSSPPASTKFDSSFAWFLAFMLVTVFLLIVLLTVICILAYFVYRLRRQSARLPPGLDTEGDVIYGFSNKHAELIEYRSSAPPSNASLTDPWNTRLGSSIEHCDCHLLHREEFERRRENLIRRGVQFHTYPKSRVSSMHEERRKPSVPKNRMVERLLIEAVQQGEVNLTWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYI0</accession>
    <name>A0A0R3WYI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5805</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009140">
        <property type="protein sequence ID" value="VDM27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WYI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000582001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000582001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000582001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2126411at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055325">
        <property type="entry name" value="CF161"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000582001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18927" checksum="A9581A214F8E337A" modified="2016-01-20" version="1">MLVGETVSCHYGISDVAPGELLGLLCPPPLAERVRVNHSRERPPVIISVDIDESLLYGAMKLSEGVKIVASTMVKSVARSIFQVISPVDCPSECKVTYETPVQFVLAGEDLSNTPLYIASDIVTSIGATNSRSGQRRVFMHADKQDHNTLWKFQHIDPRVRLELEGSPVPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYL6</accession>
    <name>A0A0R3WYL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IMPDH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5841</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01009325">
        <property type="protein sequence ID" value="VDM27789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYL6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000585601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000585601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000585601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000585601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16614" checksum="3E47404B35057AA8" modified="2016-01-20" version="1">MAGGPNPNHTPSPINYVSEYARNYDVPVIADGGISAAGMIVKALALGASTVMMGSLVAGTTEAPGEYFISKGFRVKKYRGESHFLDQKCNVDCLSLEAFSNNVCCPMKCRSWILEMVGKLVRELRIIEVVWRTEIVLPCIPVGLSTSFNVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYQ5</accession>
    <name>A0A0R3WYQ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHM7_ext domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009528">
        <property type="protein sequence ID" value="VDM27873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYQ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000589501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000589501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000589501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000589501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17927" checksum="997B88CAF406436F" modified="2016-01-20" version="1">MPLQLRIYCVNTDTVYFLLTITANDVVANWYQEASRFKYGREPVSIQGIAHKLAVIPVAANICSLFLLLFGGPLTSPPFFVFGGGGGVQEGGMRRQKAAQQKRTCRIHACGVALLRYHGVPTHFSPPVHEAHFLTKNYDALQRCLSFTDFTVKAAVSSTDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZB9</accession>
    <name>A0A0R3WZB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosylmethionine mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6113</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZB9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000612801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000612801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000612801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000612801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="23608" checksum="EA2C26C33B2F459B" modified="2016-01-20" version="1">MLPHEKATALLSGATAGLCVDFVVYPLDTIKTRLQSIATSVKPSGRLHLFAGFPAVLSGSAPGAALFFCAYEMTRNRTSGVAPPWLSSMLAASLGEMVACIVRVPCETVKQRAQNQPHLSFSRGLGGMYRGYLSTILRELPFSLIQYPAWESLKVCGNGSLSKGQFALCGAIAGAFAGAFTTPFDVIKTRIMLAEVSSTFRCDALLSAETIVFRTLNPLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZH7</accession>
    <name>A0A0R3WZH7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6183</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WZH7"/>
    <dbReference type="WBParaSite" id="TTAC_0000619801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000619801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000619801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000022">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF925">
        <property type="entry name" value="UBIQUITINYL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1857"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1415"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2118"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2827"/>
            <end position="2892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2835"/>
            <end position="2865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2880"/>
            <end position="2892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000619801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2892" mass="324501" checksum="0DA7A087CCA993E7" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZZ9</accession>
    <name>A0A0R3WZZ9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6397</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZZ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000641201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23431" checksum="08FF1F656216E4FF" modified="2016-01-20" version="1">MHRVFGRSSNSAKVAPPNLTDAAANVFIDSRIETLDKSISLKRGEIVKLQSQMRGMREGPAKASLKRQALTKLKQMKVLEAQRETLSGQSFNMGQASFALQSVKDTQMTVKAMKQGVKEFKKETKNLKLDDVEDLQDDLADMLELNDEFGEALGRSVMPTTIDESELDAELEALSSEADLEGFLNADTAPSVPSADVGSSISVPSAPNAAASVSCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0A7</accession>
    <name>A0A0R3X0A7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme biosynthesis protein HemY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6532</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0A7"/>
    <dbReference type="WBParaSite" id="TTAC_0000654701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000654701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000654701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244800at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000654701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15318" checksum="A63C7FA3DE596184" modified="2016-01-20" version="1">MNIRIVTCVLLSIAILFTIIGVATNQWIGGNLLRNSGNYAVTAKAVGYLLIVGAAVVLLRCRGWLRVRASSGNSGAHVHSLHSEANHNTARYTCYTLRTLRKHLRERKVLYCSRLKHVVSILSFSLTNTNVSVCVHLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0L5</accession>
    <name>A0A0R3X0L5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RFX-type winged-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6668</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020314">
        <property type="protein sequence ID" value="VDM30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0L5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0L5"/>
    <dbReference type="WBParaSite" id="TTAC_0000668301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000668301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000668301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="233"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000668301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1108" mass="116571" checksum="169E3C9140129807" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X112</accession>
    <name>A0A0R3X112_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6842</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X112"/>
    <dbReference type="WBParaSite" id="TTAC_0000685701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000685701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000685701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000685701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21420" checksum="4832C557D65BDED7" modified="2016-01-20" version="1">MNSDIIDPGLFDIPLQQPALLSHGDSSGSCLNTRRVYRPVSEEKRKSREYRVSRERNNRAVQRCRANNKVKQDCLVIKSEGYRALAEEYRKATYELDAERKRLEEFFRMRMATGQDTGHLQALLGEENVTRAAFEEHIETIRKRYARRVQAATEGRQTDISITTSPPSSASPPYSLSSQSSLRPQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X187</accession>
    <name>A0A0R3X187_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6932</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020333">
        <property type="protein sequence ID" value="VDM31220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X187"/>
    <dbReference type="STRING" id="6205.A0A0R3X187"/>
    <dbReference type="WBParaSite" id="TTAC_0000694701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000694701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000694701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000694701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="16029" checksum="9CBE342903CB8C01" modified="2016-01-20" version="1">MALKPLPHPKIVKKHPKKWHRHQSDRYVRLGTKWRKPKGIDNRVRRRFKGQLRMPKIGYRTAKRVRHIHPDGFKHVLINNVKELEVLMMQHRTHAGVISRTVSRKNRVKIVERAKELNIRVVNPNAKIRLTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1L1</accession>
    <name>A0A0R3X1L1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho GDP-dissociation inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7089</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020344">
        <property type="protein sequence ID" value="VDM31406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1L1"/>
    <dbReference type="STRING" id="6205.A0A0R3X1L1"/>
    <dbReference type="WBParaSite" id="TTAC_0000710401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000710401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000710401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000710401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20959" checksum="171FF3D8DA9B68A1" modified="2016-06-08" version="2">MAASEGDEADLLNNDDGYKAPEKKTLDELVKLDAEDASLQRYKESLLVPNDPRKFILVKLEICVRDGPTHEIDLKNLDGLKDKPIEMIEGSQYHVQVTFYVQHEIISGLRYAQKTTKNVLRSVDKVMLGSYAPRATPYVWRSEDEEVQSGALFRGHYNVTSVFTDDDEQEHLKFRWAIKIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1P3</accession>
    <name>A0A0R3X1P3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7132</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020348">
        <property type="protein sequence ID" value="VDM31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1P3"/>
    <dbReference type="STRING" id="6205.A0A0R3X1P3"/>
    <dbReference type="WBParaSite" id="TTAC_0000714701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000714701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000714701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000018">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000714701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19067" checksum="77E325DA989D9EC5" modified="2016-01-20" version="1">MASSASSLLLRKQLAELNKSGTEGFSAGLIDDDNIFKWQVLIMGPADTLYDGGWFKATLEFPQDYPNHPPKMQFLTDMWHPNISPSGSVCISILHEPGEDRFGYERPEERWLPVHTVETIIMSVISMLAEPNPDSPANVDAAKMFRDDYEEFKRRVGQTVRKSQESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1V3</accession>
    <name>A0A0R3X1V3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS7203</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01020353">
        <property type="protein sequence ID" value="VDM31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1V3"/>
    <dbReference type="STRING" id="6205.A0A0R3X1V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000721801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000721801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000721801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="20">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDM31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000721801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="839" mass="94798" checksum="D373CADCD12BDA70" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2C7</accession>
    <name>A0A0R3X2C7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GBD/FH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7421</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. Diaphanous subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020372">
        <property type="protein sequence ID" value="VDM31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2C7"/>
    <dbReference type="STRING" id="6205.A0A0R3X2C7"/>
    <dbReference type="WBParaSite" id="TTAC_0000743601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000743601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000743601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.40">
        <property type="entry name" value="Formin, diaphanous GTPase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044933">
        <property type="entry name" value="DIA_GBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF1">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="78"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="580"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="883"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="965"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000743601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119789" checksum="B34D2CB3165FC069" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2D8</accession>
    <name>A0A0R3X2D8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7434</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2D8"/>
    <dbReference type="STRING" id="6205.A0A0R3X2D8"/>
    <dbReference type="WBParaSite" id="TTAC_0000744901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000744901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000744901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000744901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12653" checksum="960F4EFFB963C888" modified="2016-01-20" version="1">MARGQAVKRSVRKDAVTREYTINLHKRIHGVGFKKRAPRALKEIRKFARKMMGTDDVRVNVRLNEVRVKLARKRNEDEDSPHKFYTLVSYVPCSDFKGKQNINVEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2S8</accession>
    <name>A0A0R3X2S8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Guanylate cyclase</fullName>
            <ecNumber evidence="2 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS7600</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 14"/>
    <dbReference type="EMBL" id="UYWX01020386">
        <property type="protein sequence ID" value="VDM32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2S8"/>
    <dbReference type="STRING" id="6205.A0A0R3X2S8"/>
    <dbReference type="WBParaSite" id="TTAC_0000761501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000761501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000761501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF507">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133160" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="255"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="643"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="837"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM32009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000761501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="913" mass="102479" checksum="3C4F83F0DC42F400" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X386</accession>
    <name>A0A0R3X386_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SERTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7779</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020404">
        <property type="protein sequence ID" value="VDM32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X386"/>
    <dbReference type="WBParaSite" id="TTAC_0000779401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000779401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000779401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000779401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10203" checksum="6673EF046FE2A722" modified="2016-01-20" version="1">MIATANLSDLRSTAKTSEEYIATLEKKLAQLKGSKCVTSADLVLSINGMKSVVLHDTLMNSENFQDSDVSSEETDPLISLDLLDAVHNMLSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3A7</accession>
    <name>A0A0R3X3A7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7804</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020406">
        <property type="protein sequence ID" value="VDM32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3A7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3A7"/>
    <dbReference type="WBParaSite" id="TTAC_0000781901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000781901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000781901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF963">
        <property type="entry name" value="AT08303P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133153" evidence="1">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000781901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25602" checksum="7C20E56D4F6B13B9" modified="2016-01-20" version="1">MHIVPLLTILCPLVRCGNYVHIPPNWLCYVAPEIMRALNIGNPANELPFTPESDVFAFGTVWYELLTCEYPFRGLPTETLVYLVGTGIKPPLKLQCPRDFKLTLVRFDNIFNMAIICIELDTAVNLLLFVIPWHFLQEVMRQCWSYHPQDRPEFTALVKQLDRLPKLHRSPSYPTKPHSAFAIVSSSGASASSNAASGTTSSIVGGGGGGGSGVGGGEARISGNRLILPLLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3J2</accession>
    <name>A0A0R3X3J2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020419">
        <property type="protein sequence ID" value="VDM32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3J2"/>
    <dbReference type="WBParaSite" id="TTAC_0000792101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000792101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000792101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000792101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12352" checksum="A4ABB6039E557A4B" modified="2016-01-20" version="1">MRITCRHYASASDVLAKANLMNQVIDGLSASSLEEELLSEPQGSIGGKEMYIYHSFALSSGCGDCSVRCDASISIRGHVQQPEDVSQEVKRSVSPKSDSEASIDGLVTATTSNVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4U8</accession>
    <name>A0A0R3X4U8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8439</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020506">
        <property type="protein sequence ID" value="VDM32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4U8"/>
    <dbReference type="WBParaSite" id="TTAC_0000845401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000845401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000845401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279276at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000845401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="613" mass="67098" checksum="5801607BA43470C5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X546</accession>
    <name>A0A0R3X546_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dynein axonemal assembly factor 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8555</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020532">
        <property type="protein sequence ID" value="VDM33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X546"/>
    <dbReference type="STRING" id="6205.A0A0R3X546"/>
    <dbReference type="WBParaSite" id="TTAC_0000857001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000857001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000857001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000166">
        <property type="entry name" value="Dynein assembly factor 1, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000857001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="955" mass="106990" checksum="8E6AD2371C04D99B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5K0</accession>
    <name>A0A0R3X5K0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020573">
        <property type="protein sequence ID" value="VDM33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5K0"/>
    <dbReference type="WBParaSite" id="TTAC_0000875001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000875001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000875001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000875001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9768" checksum="61FFF51F4A24F42D" modified="2016-01-20" version="1">MHAKDRQEVEKKQTSNYAEGGRAKCVLLRLPIAVTVAFAWSRRLPEVGRTMDHTVTSTFFLTAQSACILSSLVYKSGRVNFFCVTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5M4</accession>
    <name>A0A0R3X5M4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-nucleotidase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8764</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020581">
        <property type="protein sequence ID" value="VDM33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5M4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5M4"/>
    <dbReference type="WBParaSite" id="TTAC_0000877901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000877901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000877901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000877901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43516" checksum="9FEA9EAD865AE16A" modified="2016-01-20" version="1">MQPPLTTEDLDAECFFGNLHKGKYQRRTKNRFISPSYKIFCLLRIFVNRSLRLDRIRFFGFDMDYTLACKALSETYKSPQYEELAFKILRDRLIEFGYPQELSQFEYEPSFPVRGLWFDQQYGTLMKIDQFGNILMCLVGFNVLSNEEIGELYPNRFIKYEKDRIRVMSTLFDLPEIYLLACIIHYMHSNDVYIKEPHGVKYQSLYISYKSILQDVEEAMSWMHMGELKKQTMANIENYIEQNPKLLVLLDKLRTERTYVFLLTNSDYEYSDAVMKYLCNLPDKDGNVRHWTTYFDYIVVDAKKPVFFQEGTLMRAVDMTTGRCKMGQIAGPLERSKIYAGGKDLALVKVHIERYLNDPTIVASVPTICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5P9</accession>
    <name>A0A0R3X5P9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IST1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Charged multivesicular body protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8792</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4. Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies. Interacts with SPAST.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020589">
        <property type="protein sequence ID" value="VDM33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5P9"/>
    <dbReference type="STRING" id="6205.A0A0R3X5P9"/>
    <dbReference type="WBParaSite" id="TTAC_0000880701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000880701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000880701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000880701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34799" checksum="9D64D61C4F279B43" modified="2016-01-20" version="1">MFAPKFDPNKLKTNLRICSVRLKNLYQKKNELNIRARRELAEYLKAKKIDRARIRVEQIVREDYLLEVLEIIELYCELLITRLGLITSTVECDPGLKEAIATIIWVAPRLSYDCQELEVLKTQFSIKYGREFAQLCSTNSNHCVNPKVMYKLNVKAPPANLCEAYLVEIARSYDVEFTPDMNILSNSQLIDLGDPPELPSYDFMLHDTLKPDNAAAGGGVPYPTNYGPKDDSNTALPSLPPESSSKLNDLLGPESPPPYSHPSSPTGKKPESADQNNGEDKVSDLPPPPANDDDDFDALSARFNKLRKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X612</accession>
    <name>A0A0R3X612_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020627">
        <property type="protein sequence ID" value="VDM33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X612"/>
    <dbReference type="WBParaSite" id="TTAC_0000893001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000893001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000893001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000893001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20094" checksum="B4C75A6B92E58CC7" modified="2016-01-20" version="1">MSHAPDLDTRNCILRPAKGIELLEPFNQQWNENNWTSFGSENSQDSCISLAEFNSTASTVAKPLPKLLSVHQLMDRLDCELSRCKALLKKTVDDLTDTNQLMNGNASEQKELVRKTEESVRNARTLLTKVHQHIANTHEFCNMLHRMDEALQLFSKTAYSVATLEQVKLEDPSRHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X681</accession>
    <name>A0A0R3X681_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8990</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020647">
        <property type="protein sequence ID" value="VDM33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X681"/>
    <dbReference type="STRING" id="6205.A0A0R3X681"/>
    <dbReference type="WBParaSite" id="TTAC_0000900501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000900501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000900501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000900501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21495" checksum="D46DC9BC1C4E1102" modified="2016-01-20" version="1">MFLENVPWQSYVWLLVRIFVAEVIGSGIFVLPGILISTPTQYEPLVKGIAMGGGLYVAIWITYPTSGAHINPIISLVAFLFRNIKLQHLVFYWIAQLIGALLSTLIGLSIVPSGGNETFRGMTFPHPEVSERQAFLVETFTTSVLVIVYLATIDLRRPENWGLNTGLNMALPLMFTVIGNAIVAVIDITVSQYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6V3</accession>
    <name>A0A0R3X6V3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9241</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01020729">
        <property type="protein sequence ID" value="VDM33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000925601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000925601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000925601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430326at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF11">
        <property type="entry name" value="URIDYLATE-SPECIFIC ENDORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000925601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25034" checksum="3275BE344D0BF727" modified="2016-01-20" version="1">MVIKEWERSPTTAIKNLIMRLPNEHLFYCILNLLTLTLSTGCMSNFKLHQAIANAWFRTSVRGIMEQPHFAVNTAFQHVFIGEKSNTNVLGLHHGGRAFLLYDSGRLHLLDVNRRHHKYNILDFSFEWDGLLKKRSTIFFGLPVEFEMLLYFISCIYSKHGEFRLLLDKEEIKIKNFMGTNCDRFINATKVKTAPHLICLAKNRFRQYHQDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7P5</accession>
    <name>A0A0R3X7P5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9555</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020888">
        <property type="protein sequence ID" value="VDM34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7P5"/>
    <dbReference type="WBParaSite" id="TTAC_0000957001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000957001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000957001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284556at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000957001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="496" mass="53463" checksum="A9B227BA40C06A1E" modified="2016-01-20" version="1">MLTDSLKPEYYRNKGRPPLTGLSDHYQHCHFFGSTTNGNAAISTTTEDLLLMDTNSSTTGFLRQASLSSASLLGDLNGKPLFYMPALSADVDPLLPVSESSSKSSPSSCSDASLIAPTNSVPDTASTSLSPQLNLVGRLVIGEFFTCITFIDDILDFEERSSRLRHLREGVVTMCSLVVQRFGLQDLSKVTVSSRRSTKSKHRRNQTNNSSLSSPQSPSPPKPPKSSTPEKFLPKVCSTTSSSKVEEVEEEKATVTVTVDAIPVIKVSDSSDTNNAVLENGNEEVDDDEGGFIMVTTKKRNRQARSAAKANNASGHRFTRPQHPALLSPLPPTPLPPRKLLSPLQSNKATSKAGQLYAQRMDKFHKNSGLDFSTYASLVLLVVVVGAIALRTSHLTLTTHLVDTQALPLFPVAKTSEEVVVRTAEVCESPSVFSLLLPHPPPPSPLPHTSFLSLPSIASSFADPVGLSFYESGLSSSPSSYLYLSSLFLIAVASIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X816</accession>
    <name>A0A0R3X816_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9676</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020974">
        <property type="protein sequence ID" value="VDM34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X816"/>
    <dbReference type="STRING" id="6205.A0A0R3X816"/>
    <dbReference type="WBParaSite" id="TTAC_0000969101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000969101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000969101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10404006at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="127"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000969101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26646" checksum="483DB8BD58BE86F9" modified="2016-01-20" version="1">MTGLGACGSLVGSEGQIRLTSNVALERPIPEGTEVTLTCSSDSSSGSGVLRILRRRGGGEGIDGFEDLADYATRVVQISADRPDIAATFVVSRKDDGSVFICGDVETLGFQSQTSVVSRTIRIQFDPRSLSLKSLPEGRMREDMSKVIICQTDEGGANPAVNVTWRHLSPLGGIEALGEGMHFTSAHRMSTSGNGRGFVTQSNLTVIAHRRLNGHRIECSVEKPERIALLRQSETLEVIFLYLYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X883</accession>
    <name>A0A0R3X883_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9743</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021015">
        <property type="protein sequence ID" value="VDM34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X883"/>
    <dbReference type="STRING" id="6205.A0A0R3X883"/>
    <dbReference type="WBParaSite" id="TTAC_0000975801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000975801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000975801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000975801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24007" checksum="8EDF6E4F1C843C39" modified="2016-01-20" version="1">MNFFRFLGDFSHFVAIIILLLKIWKTRSCAGISGKSQMAFAVVFSARYLDLFTTFISVYNSVAKVVFIVSSYATIYLMFFKFRATYDSNHDTFRLELLVISSAILALIINHQFSIFEILWTFSIYLESVAILPQLFLISKTGEAETITSHYLFALGSYRALYILNWIYRYLFEGYFDYIAVAAGVVQTLLYLDFFYLYVTRGWCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9B7</accession>
    <name>A0A0R3X9B7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10127</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021337">
        <property type="protein sequence ID" value="VDM35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9B7"/>
    <dbReference type="WBParaSite" id="TTAC_0001014201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001014201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001014201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001014201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9250" checksum="F52F501157ABB0D1" modified="2016-01-20" version="1">MRDLEVFVSTPSASGGKSQRSVRIVCTPLFVLSSVYFTHLIVWAMIPVVSSLLLLAFVEATVVEEGDWQGMTSYVVTVVLMVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9G6</accession>
    <name>A0A0R3X9G6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10176</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021393">
        <property type="protein sequence ID" value="VDM35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9G6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9G6"/>
    <dbReference type="WBParaSite" id="TTAC_0001019101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001019101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001019101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001019101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25077" checksum="EBCDF586EF69A086" modified="2016-01-20" version="1">MSSSEEVSWILWFCGLRGNEFFCEVDEEYIQDRFNLTGLSEQVPNFRAALDMILDLEPVDEMPNDANEPDIIEQAAEMLYGLIHARYILTNRGLMMMGDKWLQGDFGYCPRVYCDNQPCLPIGLSDIPGEAMVKIYCPRCQDVYTPKSTRHHHTDGAYFGTGFPHMLFAVHPEYRPKRAPKQFVARLYGFKIHPLAYQLQYQAAANFNAPMRSGGFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9G8</accession>
    <name>A0A0R3X9G8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Luc7-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10178</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021394">
        <property type="protein sequence ID" value="VDM35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9G8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9G8"/>
    <dbReference type="WBParaSite" id="TTAC_0001019301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001019301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001019301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266921at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001019301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43901" checksum="DD6DF3133658107C" modified="2016-01-20" version="1">MALASQAALLDELLGKNRDAIDSDAMKGPHWSDEDMCRYFLCGFCPHDLFVNTKTDLGPCDKMHDERLRENYRKSNRFEKMGYEEEFYRYLCYLLEDVDKRIRRGHERLSVNKGAAPADPEAAAEKADKIASLTRRINDLVEQAEQLGTEGNVDQAQGVLKLCEQLKFERSQLEGDTRPGAGQSKELEVCEICGAFRIKDDAPQRVEEHLAGKMHLGYAKIRDYVREYGEKRLREREREREARASRQRASNCSWMIISAPTYQAIRSVQNGRRLLIEVKHFCKSFPKISGFYNNSAFVVGRTVTGRSSKHRDRHHHSGSHHRSGHGDKRRRDRSRSRSHSKKHHDRHQRRHSERISHKPPKRTVSPFSAARRPPEGAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9T7</accession>
    <name>A0A0R3X9T7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10296</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021517">
        <property type="protein sequence ID" value="VDM35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9T7"/>
    <dbReference type="WBParaSite" id="TTAC_0001031201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001031201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001031201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6237318at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001031201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15628" checksum="4527824B6D9AD1B7" modified="2016-01-20" version="1">MIELSSSWELQGRRKLSDVLFIKEVQLDNQCCDDEDIGGDLAVDVSCEFASKPVILQPYLHPEVSSAGPCCIMIRLSTQRNLRIVQVVLISSSSHIDFVDRYGEALARIEGVSVPGLESLFRCSSGRLSPHTECVVRVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAB1</accession>
    <name>A0A0R3XAB1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10471</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021741">
        <property type="protein sequence ID" value="VDM35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAB1"/>
    <dbReference type="WBParaSite" id="TTAC_0001048801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001048801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001048801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001048801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35991" checksum="B40DF1367BC52FF0" modified="2016-01-20" version="1">MKPDPILLPPHGYQPSISPVLQQQQLERYSVFVIPIPTSSALVEPIIVNLSNSLHPPFLPITLKLNSPISAFLGEVRGKPSFPSLDDREMGMKLINPSLPFLYLLYPTRLKTLSVTHGPASPNTPLPLHFPKPKKQNMERRRRVCMSNKFSALYDLSVSLVGEKPLFNRGVIRRIATGSADLGFRVEKPAPNGDRFNIDGSAFPVIYTPCQQRGCRKKESVVGGVDNIISPPIDITVPPSSSGQLLKQPREPAPTLFIGAVDEVKLIALNTARQLNEVQNEGGQHESLVRLCQVCVSSQRLHVPTRPTDPKVGTPLGTSVGACVCVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAE5</accession>
    <name>A0A0R3XAE5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10505</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021778">
        <property type="protein sequence ID" value="VDM35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAE5"/>
    <dbReference type="WBParaSite" id="TTAC_0001052201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001052201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001052201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001052201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8336" checksum="B7E6E83BC439018A" modified="2016-01-20" version="1">MAQKCKDLRRLIRKYGEDAVAVEGVDPVSTGTNGKGEPEAEDTKPLCLDLDTSHTAVSFVPLHSSVPPLSNITFPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB96</accession>
    <name>A0A0R3XB96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKS_AT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10806</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022267">
        <property type="protein sequence ID" value="VDM35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB96"/>
    <dbReference type="STRING" id="6205.A0A0R3XB96"/>
    <dbReference type="WBParaSite" id="TTAC_0001082301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001082301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001082301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052760">
        <property type="entry name" value="Mitochondrial_malonyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170">
        <property type="entry name" value="MALONYL-COA ACP TRANSACYLASE, ACP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170:SF2">
        <property type="entry name" value="MALONYL-COA:ACP TRANSACYLASE (MAT) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="1">
        <location>
            <begin position="50"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001082301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39390" checksum="634C5A1ECA7D2949" modified="2016-01-20" version="1">MRFIRTCCSVVQSSHGTPSSPFKNCERPDVWCQYYDRPSQEPIESTSVLLFPGQGSQFVGMAKNLLGVKGVKEMFETASSILRTNLLKTCLEGPAEKLKQNIHCQPAVYVTSLAAAKKLAIDSPELVEKCVAAAGYSVGEITALVYAGAYTFEEGLHLIRVRAEAMQRACDLIPGGMLTVQLSHDSQLRIALSAAVNHCKEELKLNVPVICQVSCFLGPECKVIAGNNEALDYIMGHAQHFRLGPLRKLDVAGAFHTPLMLPAVEPLKHALQRVGSARTPCIPVVSNVDAEPYGKGSTVSFRLTKQITRPLCWEQSLHALFSRPDGAPFPRIVEVGPGRQLGATLRMVNTKAFARYESVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBW9</accession>
    <name>A0A0R3XBW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11029</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022766">
        <property type="protein sequence ID" value="VDM36009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001104601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001104601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001104601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001104601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25468" checksum="23C95A7B9485D9CC" modified="2016-01-20" version="1">MCREKSQLHCLDDENYATSTHPRSRSLAVKRTVQSHKCTVNVPVWKWARHTTFHCRRVIGKVNSVFLLLLLLLLLLLTLPILLLHARYTPPTIFATANLELTYTTPNLALPCLALSTVCQFHHFASSQESTIPHHLTVANSSCQCCVTALMTDQRDWHEGILNEEVSIDEQVEGVGATRKSYSTAMTLFSVHVVHIIXXXXXXXXXXXXXXSSSLYSRGFSATRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC55</accession>
    <name>A0A0R3XC55_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PSP1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11115</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022992">
        <property type="protein sequence ID" value="VDM36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC55"/>
    <dbReference type="WBParaSite" id="TTAC_0001113201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001113201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001113201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254633at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001113201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61509" checksum="00A84758C300DD1F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC96</accession>
    <name>A0A0R3XC96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023088">
        <property type="protein sequence ID" value="VDM36136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC96"/>
    <dbReference type="WBParaSite" id="TTAC_0001117301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001117301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001117301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001117301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16205" checksum="25C667FC70FFFA0F" modified="2016-01-20" version="1">MLSVSSCFSLSSPPLTLPPYHFPLPVSSSSLLHLLLPLLPFSPSFPVLLSPTTTTTTTTTTSTSTSPSSFSSSTIASADLFSSLPPVLHHLPPRLSSDGGRLDNLCPLISVVSGSPLLPRLTVSDSKTAVSLTAERCLGTLICATKSAVSHQPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCD5</accession>
    <name>A0A0R3XCD5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Smg4_UPF3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11195</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023180">
        <property type="protein sequence ID" value="VDM36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCD5"/>
    <dbReference type="STRING" id="6205.A0A0R3XCD5"/>
    <dbReference type="WBParaSite" id="TTAC_0001121201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001121201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001121201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001121201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27476" checksum="1FD4413D550629B4" modified="2016-01-20" version="1">MRNLPTKIIIRHLPPKLTEEHFKEMCSPIPPYDYFRFCSTDPSLGGKNFCRAYINFCDPESVFAFRERFSDYVFVDSEGNEANAIVEYAVFQGTPNTPPLSKVDRRQGTIDEDSTYQKFLANLNTSPSEPTTGEESSAGKQVAKTPWEATLEALEKREAAASQQVETALTRFLNMRLERSKRNAGDDFKGMSRRGMRPSRNSRKARQRQAAATSSIPLGNSDATPQCADSSQKSADTNSISVGEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDI9</accession>
    <name>A0A158RDI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS705</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000081">
        <property type="protein sequence ID" value="VDM16870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDI9"/>
    <dbReference type="STRING" id="6205.A0A158RDI9"/>
    <dbReference type="WBParaSite" id="TTAC_0000070401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000070401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000070401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF1">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000070401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="768" mass="82180" checksum="E3E6642DA8CAAD87" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDL1</accession>
    <name>A0A158RDL1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS869</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000116">
        <property type="protein sequence ID" value="VDM17108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDL1"/>
    <dbReference type="STRING" id="6205.A0A158RDL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000086801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000086801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000086801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="4">
        <location>
            <begin position="734"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000086801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112861" checksum="0CFAE2ABD83E876E" modified="2016-06-08" version="1"> </sequence>
</entry>
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    <accession>A0A158REP3</accession>
    <name>A0A158REP3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020401">
        <property type="protein sequence ID" value="VDM32205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REP3"/>
    <dbReference type="WBParaSite" id="TTAC_0000777001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000777001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000777001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000777001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15524" checksum="C8E65F38403AB600" modified="2016-06-08" version="1">MGPPAAPYTTTNALEPGVASLHHHDEALHSSSVEDWRGAEAVALVSRLLTMATRMLSRAPLDTVLNTCHDKVTASNVPSTLHGGQQSPSRKGDEGGTGVSERQLVIDSLQLGGEWLSVRYGKTATEGLQCDRKRVTLRADRIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REX0</accession>
    <name>A0A158REX0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8237</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020470">
        <property type="protein sequence ID" value="VDM32753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000825201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000825201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000825201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10370269at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000825201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="67753" checksum="AE235C3C3AD4EC52" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF27</accession>
    <name>A0A158RF27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8651</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020556">
        <property type="protein sequence ID" value="VDM33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF27"/>
    <dbReference type="STRING" id="6205.A0A158RF27"/>
    <dbReference type="WBParaSite" id="TTAC_0000866601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000866601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000866601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6154712at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000866601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1244" mass="135927" checksum="B36C1E0490EE4D10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EF91</accession>
    <name>A0A3P7EF91_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01001755">
        <property type="protein sequence ID" value="VDM21650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EF91"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM21650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="538" mass="61196" checksum="D3465079606C1C70" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EG80</accession>
    <name>A0A3P7EG80_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001137">
        <property type="protein sequence ID" value="VDM20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EG80"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15553">
        <property type="entry name" value="PHD_Cfp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="10">
        <location>
            <begin position="208"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="10">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="87916" checksum="BB72437E478661F7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EHD2</accession>
    <name>A0A3P7EHD2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS82</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000006">
        <property type="protein sequence ID" value="VDM15807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EHD2"/>
    <dbReference type="OrthoDB" id="9991292at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM15807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12639" checksum="29BA42C3E9B162AA" modified="2019-02-13" version="1">MHPYCRDPFNRTLLHFNEIPYKMCNGYCVKWIRAPLDNADLRHGDLYIRTCSSNLNVRFQISPVCFQESYTVNRRLCFCNRPKCNSALPSNSPLLLMSLLSLLATLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F7V4</accession>
    <name>A0A3P7F7V4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004149">
        <property type="protein sequence ID" value="VDM24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F7V4"/>
    <dbReference type="OrthoDB" id="6149552at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="1">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="496" mass="58062" checksum="9EF38DD49C488F5C" modified="2019-02-13" version="1" fragment="single">MEDSLDILYHFRHVVDEYRANVKESCIRHGIEPTEWYFHNNWIFKRLNAFIERLELIKKYFNSNVDYNRLEKVEVLGIVGANLSKSLADMYEEYQSAYKNFTDLNMDCLSTDDDVFLNEIQKYFKTIENYDHRMTSILLRSFSNCPDTSAMFKTIFMFGPLLERPLIAPRVEHCFYDLVEMMHRDLDECKLILDRHSDDEEMLKHAIFKNLPPASGAMAWSLQLLRRANAIMKPFQHIDHPAAKTERADKLKQKYEELVTLLSEFREVKLKELCDSAPEKCRVNLQLPLLRRDSESRLLAVNFDNQLVEVLREVHYLLMMSGEGPCEHEVSPDFKTAVPTPMDQIKAKLPSESIELFERTEPLREARLKLNQIANAYNTVLQQTYTVEYPLISTNVETFDNNLAPAFSEMNWEDYKTDFIDSNLVVISDLRDRVLTAHENLSKIGALASLWNNLPLYQGKERKFDCLIPLEDRDSIREARYREMVDAADKILRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F9Z6</accession>
    <name>A0A3P7F9Z6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020303">
        <property type="protein sequence ID" value="VDM30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F9Z6"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="2">
        <location>
            <begin position="205"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="367" mass="39672" checksum="43CCE851060041DC" modified="2019-02-13" version="1">MKTIDKNLFDDISKILPKPVCEWTENDFPDLPNQTDNALNRVLQAYSRFLSRFSTSEKSVENGNGLSTSKTQKSTFGLLLKIGILVGDIIFVAYAVEVRRLQTEADITLLCLLAVLVVITILYLIFFVLMRNPKNLVSLIGIVAMVLICMLISVHPAKNEAPLLIKPYMSQMTNSELHAIMVNGFASIAGPVMVVYINFGIPANHLLIACVMSAPAALAIAKILYPETKQAPLAKGTRNTLHSSPFTNPIEAATVGALEAIPLCAGIIVNLMAFLSIFSVFNRILTWLGHRIGMSRKTIVISSYALCGFANVGSVGILLGTFIKMLPHRRKDLSGMVVHGMIGGTIAAFVTACFAGTQGSSQVETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCC1</accession>
    <name>A0A3P7FCC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006622">
        <property type="protein sequence ID" value="VDM26484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCC1"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="203" mass="21841" checksum="408F51B001127A58" modified="2019-02-13" version="1">MPNTSAQHLFTQRTTGHFPLTPVACVLLETQKSKKLHSALLYLDPILGVPLNPRTLEPATKAEEAIVHLPSRVKVAALVPTTASGMLSTLGGEAEAEAANHVRPLCVVLENLSVMLLPPTLSTINPRILLPAHGLYIFALNTEPATVSGYRVMTVNRNVTAATTNLTAQLLWHMHLSSEDYPQRILQAAVHPPSGESPSLSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FRU9</accession>
    <name>A0A3P7FRU9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FRU9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018212984" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="37" mass="3848" checksum="80751D60B0A121C9" modified="2019-02-13" version="1">MMVAVLVMPISALDAVSTSVAKKKTITGSILTHMTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FVG8</accession>
    <name>A0A3P7FVG8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020395">
        <property type="protein sequence ID" value="VDM32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FVG8"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14233">
        <property type="entry name" value="GAT_TOM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="285"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="610" mass="67378" checksum="3E81256908B4689D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G169</accession>
    <name>A0A3P7G169_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000029">
        <property type="protein sequence ID" value="VDM16312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G169"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="276" mass="30819" checksum="5C231B6BA0D66331" modified="2019-02-13" version="1">MYQCFTFFIVTGSLCQDVEISDDDPFSPAHSTSNNDSPVNENDFYRGSPDMNAILSFINPPLGHLGPSNSISLVAGKPASFIVSLENNQNSSNSYSLQILEAALHYPRYFGYHIQNFTVQRLQNTLEPKQQASLHYTFIPAAQLTGQHFDLAVILTYHDQTGKIYSHALFNETIAFLEDAEGMDVELMFLGVMIVGVCILVLIFIWHWISKKASRRPPGGKPAATFNGTDGTKFNEYVTRKSPSQLDTGNGNIFLFLVSSERHFWHLAANNSSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G2X8</accession>
    <name>A0A3P7G2X8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022209">
        <property type="protein sequence ID" value="VDM35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G2X8"/>
    <dbReference type="OrthoDB" id="10569593at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="90" mass="10094" checksum="E521B9A0611A7060" modified="2019-02-13" version="1">MTPYATDQVLLKQEEQLWASLFAPSERAVVESAKGFTAQLREMSQQVEATADEAMMELHSMDLEDKAQENIDNINAVSLEEVSSKSNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HAV8</accession>
    <name>A0A3P7HAV8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HAV8"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="314" mass="36140" checksum="06D39EC21CA5AC87" modified="2019-02-13" version="1">MPNCAPSATRTTPQRLRHAHTSQLSDFTCIKTVGTGSFGRVCLAQHKHNRRHYAIKILQKAKIVKLKQVEHTLNEKKILSCINFPFIVALKTYFKDHSNLYMALEFINGGELFSLIRKEGKFREDTARFYGAQVVLALQYLHSMDIAYRDLKPENLLIDKHGYLKLTDFGFAKVVKGRTWTLCGTPEYLAPEIILSKGYSRAVDWWAVGVLIFEMIAGYPPFFADQALQVYEKIVAGKVRFPFFMSTDARALLSNLLQGDTTKRYGNMRNGVADIQSHVWFANIDWVDILDQKVRVHCLQFLTEEDSRLRQRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HMV0</accession>
    <name>A0A3P7HMV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022154">
        <property type="protein sequence ID" value="VDM35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HMV0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="111" mass="11966" checksum="4450A9062CE51456" modified="2019-02-13" version="1">MNEVFGSSDGLRASGQRLKRADRESKFSVSGSANIGFPSGYSGLEWDFVPDNAPICRKPITTGQYFALDPAKSSRGDMGLSEHSASTEEITAISVEKVEDKLTKLGIGHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHL2</accession>
    <name>A0A0R3WHL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS36</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000002">
        <property type="protein sequence ID" value="VDM15652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHL2"/>
    <dbReference type="STRING" id="6205.A0A0R3WHL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000003501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000003501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000003501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM15652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000003501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="52009" checksum="2A06415F61250D08" modified="2016-06-08" version="3">MSHYASASKSYDEGDYAGDDDDMDDDDGYDCLSDYDGDIDGGGATVSGEGPSSGGDRRADGFAPRSSYHHGGKVSVGGNGRHRTDFRRYRNASDRVMPDHSDDNRRDHHNHLERKRRASIKGSYCDLREAIPSLRGSKASRAVTLQRAAEYIETLTKSNREHSCCVDELTRQNEILERQVQDLYRNYQRLENDEYALAQAAAVAQSGASLNQASVSGSFNAPPPPSTLPVTSSSPTASSTGNSTPTTAAHALNCGSTGSSCNSSTGFSFPLRVISQHQPSTSSNASSPDDPPSTGIPSSGLAQLSYAALQLQQQSVVSSDTIAAKPPVALTTVVTTSTPPMTRLITLDSSNTVSSASRGVVPQRIRLSNSLSTSSGGRPIVVVSTSSSSSGTSAASTTFSALDTAVLKARTSRPPLDQQQHHHHVVVGSNVEVVSSSATSTVPISVTPTSNIASPTQVLGHPRRVVIVSTQPHQECPPPPTQAAPIVSSKQSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHN4</accession>
    <name>A0A0R3WHN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NDK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS60</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000004">
        <property type="protein sequence ID" value="VDM15771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHN4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000005901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000005901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000005901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF2">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM15771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000005901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18744" checksum="D3C6D87E129B0D83" modified="2016-01-20" version="1">MRRDANKLLKEIVYGSNAKDTDVFANNDLFMPAQTPESAAKLAHILFSTPTSSLNRKLLDIKDCTCAVIKPHAVQSHRVGDIWEAIQSNGFCITAAQAFRLSKVDASEFLEVYKGVLAEYSELISEFTSGPCVALQVTRADTNRDAPRNPGDPSSVQQLFRDIVGPMDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHS2</accession>
    <name>A0A0R3WHS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS110</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000007">
        <property type="protein sequence ID" value="VDM15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHS2"/>
    <dbReference type="STRING" id="6205.A0A0R3WHS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000010901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000010901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000010901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000010901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="996" mass="114541" checksum="4061CED7BCABC3E6" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIF6</accession>
    <name>A0A0R3WIF6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4808 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS380</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000031">
        <property type="protein sequence ID" value="VDM16331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIF6"/>
    <dbReference type="WBParaSite" id="TTAC_0000037901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000037901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000037901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278341at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000037901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35206" checksum="B2DFAC59E437BD55" modified="2016-01-20" version="1">MDWSQFADPQFLLGVGVIAFGAINAYMLRRHNLQRAEEEAEHSGVRGNESVKRQEVRESTETTECSRFLDDGYQKEKCEKPKSNDWNPTENAAMEGKQVKKISVSFRKLFRNRSVSKTRDPFSSTHFNPKSTKMDHCNRSRLSKSLSTFFVNCCQCCACCYGWGNTTDSPPYADDFHHRCRGPWKKSDRVSASEPQLSPPPPTVLPSIRVRFENQIPEMEGKDHISRRKEVGQKFRDEVDAEIISASLDDQLMLERKLDEGNAQRGRQEDEFSESSETVTIEPNSVSLQIYKADFVHQFPFVVTQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIP2</accession>
    <name>A0A0R3WIP2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynein axonemal heavy chain 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">TTAC_LOCUS479</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000043">
        <property type="protein sequence ID" value="VDM16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WIP2"/>
    <dbReference type="WBParaSite" id="TTAC_0000047801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000047801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000047801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001112">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="20">
        <location>
            <begin position="481"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="21">
        <location>
            <begin position="1076"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="25">
        <location>
            <begin position="1570"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="26">
        <location>
            <begin position="1927"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="23">
        <location>
            <begin position="2088"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="22">
        <location>
            <begin position="2375"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="24">
        <location>
            <begin position="2750"/>
            <end position="2970"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="19">
        <location>
            <begin position="3262"/>
            <end position="3376"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="27">
        <location>
            <begin position="3412"/>
            <end position="3550"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="28">
        <location>
            <begin position="3559"/>
            <end position="3870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="392"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2601"/>
            <end position="2659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="VDM16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000047801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3874" mass="443125" checksum="87CC4517496220D5" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK70</accession>
    <name>A0A0R3WK70_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1104</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM17473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0R3WK70"/>
    <dbReference type="STRING" id="6205.A0A0R3WK70"/>
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        <property type="gene ID" value="TTAC_0000110301"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament polymerization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARPC2"/>
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        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
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        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
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    </dbReference>
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        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000110301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36831" checksum="501CDAD2D45E3EF2" modified="2016-01-20" version="1">MILIRPFHSAVKDIVLAQLLANKEYQQHRDKSSTVPDIAENVSDFDGVLYSIVQKPDSNILTVSISLSFYQEIEKFGDSKVLVREYGSYLKPRAESGTSVTLEFDCNRLPSDLEAVATKAALLRRNCFASVFEHFFDYQVANASSASAKVLQGTIHFRPDETMFVQAMSDRVTVIFSTRFKDPDDVVLGKVFLQEFAEVKRRFDGAPQVIYQPRDPPKELQGTDAASGENIVYITFILSPRHASPQFRANTIDLIHLMRTYMHYHIKCMKAYLQLRMRAKTSEFLKVLNRAHPDSDVIASRNYAVNDSDPSGIQMLGSSASSEGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKI6</accession>
    <name>A0A0R3WKI6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3_10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1228</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000225">
        <property type="protein sequence ID" value="VDM17657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WKI6"/>
    <dbReference type="WBParaSite" id="TTAC_0000122701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000122701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000122701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Desmoplakin SH3" evidence="5">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="372"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000122701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1995" mass="218830" checksum="C9AA7A6E67D6610E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKJ4</accession>
    <name>A0A0R3WKJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sortilin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1237</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000228">
        <property type="protein sequence ID" value="VDM17670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WKJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000123601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000123601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000123601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Sortilin N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sortilin C-terminal" evidence="4">
        <location>
            <begin position="337"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000123601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="646" mass="71479" checksum="2CB2256269078A37" modified="2016-06-08" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL30</accession>
    <name>A0A0R3WL30_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1451</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000320">
        <property type="protein sequence ID" value="VDM18013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL30"/>
    <dbReference type="STRING" id="6205.A0A0R3WL30"/>
    <dbReference type="WBParaSite" id="TTAC_0000146401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000146401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000146401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6817893at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042620">
        <property type="entry name" value="NSUN7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663:SF2">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000146401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="49877" checksum="861874146DA9857A" modified="2016-01-20" version="1">MASFPLTKFVVKPVAVIVYRQCVQRTSNANPGLVRHLFRKIPFQCDADLHNSSHSRCSTIAYEPAYSLPLFPKNAEAIMHDKSNLFALHCLLAFIGPGEEVMLVNHPNSLNGIHLEGLLMNKFPTVTPVPTIRVVRQPKENEDPRLIPKCGCRTTRMITDDFLTLNPGGETYRGLRHIVLESLDMKTGVVNPIDYIDCENEVNQVRTVIFVSHSVDVDETETAVQRCVEYANRTLQREMEANATPSRPATSTPGFVCRVPPGIPALAEAEAAIAAGEAGPNLITPSQCIHFAPSNLHNGFFIACIKKELLLVTQPEAPAEDDEENPDDIAANVNKKRRGDNNSTGSPLAKKYKVTIFTQFLEGSVSLVHPIQLQFQLLNYSQCQAMSMANTRAVIGGGGGTIEADDKLPRRITSKPGCRGKGTVSSWTLDEEVGVGVFSPLSMALRLNSSLNCSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL57</accession>
    <name>A0A0R3WL57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SEC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1479</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRAG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000335">
        <property type="protein sequence ID" value="VDM18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL57"/>
    <dbReference type="STRING" id="6205.A0A0R3WL57"/>
    <dbReference type="WBParaSite" id="TTAC_0000149201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000149201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000149201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033742">
        <property type="entry name" value="IQSEC_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF342">
        <property type="entry name" value="FI21420P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16453">
        <property type="entry name" value="IQ_SEC7_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="472"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000149201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="963" mass="106998" checksum="19B74B4569BA9357" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLA0</accession>
    <name>A0A0R3WLA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1525</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000358">
        <property type="protein sequence ID" value="VDM18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLA0"/>
    <dbReference type="STRING" id="6205.A0A0R3WLA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000153801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000153801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000153801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000153801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30638" checksum="8A3CB5B650EFB995" modified="2016-01-20" version="1">MYWLHFHLHSRMNVPTFTMSGHLLRCISFLSPMRKVLIPFAFRVQYVCPFSTSKCLEYTQQMTSRLTGKKTKLWDLYNEVVYPPRENTIGTTDGEIAVEPRPAEVTYTKENILYSQKKLWLLAFMIRGLSVDEAFQQLGFRPEKGARILEKALEAAIERAVTEHDVEFCTNLWVEKALVLRGDSVPRIHKGLRTTVSKSNYHYSRLMLRLREGAPPALYHPYLIRSSWHPAPNCPADGAPGWGSAHDILDIQIRKIRRRRIPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLD5</accession>
    <name>A0A0R3WLD5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-actin monooxygenase</fullName>
            <ecNumber evidence="3">1.14.13.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS1560</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51308"/>
            <dbReference type="Rhea" id="RHEA-COMP:12953"/>
            <dbReference type="Rhea" id="RHEA-COMP:12956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.225"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mical family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.225" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000376">
        <property type="protein sequence ID" value="VDM18211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLD5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLD5"/>
    <dbReference type="WBParaSite" id="TTAC_0000157301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000157301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000157301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20799at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120501">
        <property type="term" value="F:F-actin monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057494">
        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25413">
        <property type="entry name" value="Rossman_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 13" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="219"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="488"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM18211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000157301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="641" mass="72331" checksum="4C911E8F33BE0CA1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLS7</accession>
    <name>A0A0R3WLS7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1702</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000456">
        <property type="protein sequence ID" value="VDM18417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLS7"/>
    <dbReference type="WBParaSite" id="TTAC_0000171501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000171501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000171501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255016at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000171501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30378" checksum="AE86D2623518A1A9" modified="2016-01-20" version="1">MEAKLARAVQAIQSSNYSLNTVLQLQESGFDFSQLSGHVVCGLVARNFGLGIKILLSCGVKLDCVDPISGNSPLILLAAEGLCGPVRCLIGHVPVEHLHHINRSTNSVLSLLLARGHSHCGCLETLLQRFSSSTPNHLKDPCNRVILSVMDLLEQIKTSAIDRVAGVFQLWISANLIDLEDDATDAEMRKKTCELLLRRTIGTIVKDCLSGWTSPQTIRASTSKCFELFAKLLILRRLSVGFLEDCRREVDAAYSIDRPKPLEPSQIRQLDHLQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLW3</accession>
    <name>A0A0R3WLW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000482">
        <property type="protein sequence ID" value="VDM18471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000175101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000175101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000175101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262166at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000175101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21338" checksum="2E15616666B97FF2" modified="2016-01-20" version="1">MHIDSISYRLLRHVKLNSSLTGTTDDSHISDVLFGVIRPAVTHDTSTDVIELPLPCASLNDCVWTTSGTLFSCRYEVEVSIAVSLDSSLTATVGNAEYPSISFTLPVNVVPPDTCEAPALPAWTSLCLVALAEDEAGLSLQSSKPDSQEWHDLPGGSTGPCQTVRIHGGQRGAAGLTPSAAQGNPEFRKIPVFRHLGATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMF2</accession>
    <name>A0A0R3WMF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1927</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000612">
        <property type="protein sequence ID" value="VDM18667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMF2"/>
    <dbReference type="STRING" id="6205.A0A0R3WMF2"/>
    <dbReference type="WBParaSite" id="TTAC_0000194001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000194001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000194001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000194001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44256" checksum="E02454727D3748A4" modified="2016-01-20" version="1">MRLKDKNRPRSPLSGFACFVQVIRDKHRSLHPNENVIFNEFAKSLFTALLKEMPPDKRAPFEEMSRLDTKRYNREMGEYVQQQQLQQQQQLPPQPMMHPQQQQQQPQSGGQLSNFEHHHHHMRGAKRRRLKDPSMPKRALSAFFFFCDHYRSEVRNAHPEWRVSEVAKELGRLWDECSDKAPYELQAQKDKLRYEEEMRRYKEGTFVMAPKRLRDVSAMSEGGVIEGGTSDGGRGIGDGPGGVNVANCFEIEGSREADEMDGKGGEDDIDDEDVDDYEEDEEEEEEGDEEDEDADEGADEETGYEEEVRGTVEKMEEDDDAAHMTAQNEGAGVGSGGDVEKTTPNHHHNQRQAPNAFSVAYVVSGGAHKGESGIADEGVSAEGAHSATANEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMT3</accession>
    <name>A0A0R3WMT3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HATPase_c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2058</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000721">
        <property type="protein sequence ID" value="VDM18819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMT3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMT3"/>
    <dbReference type="WBParaSite" id="TTAC_0000207101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000207101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000207101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000207101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="700" mass="79584" checksum="8EAA953A34731369" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMU4</accession>
    <name>A0A0R3WMU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2069</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000729">
        <property type="protein sequence ID" value="VDM18830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000208201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000208201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000208201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000208201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8694" checksum="16D49DB8CC3E6BB9" modified="2016-01-20" version="1">MQWRSLEIVQLEWAKGSDGILVMVVRCSSQCVTSTNGKAGEEGVPGGRTRAMRRVKNQSERSALLCSALLCTAPGIAKIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMV2</accession>
    <name>A0A0R3WMV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2079</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000736">
        <property type="protein sequence ID" value="VDM18855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000209001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000209001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000209001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000209001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15610" checksum="04EF0103C54BB7DB" modified="2016-01-20" version="1">MLNFLVNPHTSKIPPPAHAVIKSTYADSIVATVRILATNTAAAATYMPTRLSDSRPPIATFISLSDARMKWSHPICQPKFPATQLLIVQSPIGGSDEERRHTNTEFPWLFTSLCSTKLTGRFHLLPLLIQCHDSLCPSTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN56</accession>
    <name>A0A0R3WN56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heparan sulfate 2-O-sulfotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2181</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000828">
        <property type="protein sequence ID" value="VDM19147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN56"/>
    <dbReference type="STRING" id="6205.A0A0R3WN56"/>
    <dbReference type="WBParaSite" id="TTAC_0000219401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000219401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000219401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001418">
        <property type="entry name" value="Heparan sulfate 2-o-sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM19147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000219401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39773" checksum="ED6041B65753429D" modified="2016-01-20" version="1">MLRRMFMNAICSWRALLTFCVCGVIALFLNLPLQPIKSVTQNQILTNASKVVVFNRVPKTGSTTVVRIFETLSERNNFHVYRIAIFNPTQLINPLSHKAFVEEVRMLSQDFNLLVHGHFYYINFRRYGINIDYVYINCLRNPLERLVSKYYFMRFGDYHRPNTQRRRMTNDSLQTQTFEECVENGGEDCDPRHLWVQIPFFCGSAAYCSIHGNPEALKTAKRRLIEDYLLVGVLEYFTEFMELLAHLIPEYLTGIEQTKDVKIGGQPLWHLRKTKLKAPIQQNTLNVFRNNNIWRMEEEFYEFARSEFLSRYQRYKHTLFDWNKWRKSVFIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNE9</accession>
    <name>A0A0R3WNE9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TTAC_LOCUS2274</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01000917">
        <property type="protein sequence ID" value="VDM19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNE9"/>
    <dbReference type="STRING" id="6205.A0A0R3WNE9"/>
    <dbReference type="WBParaSite" id="TTAC_0000228701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000228701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000228701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="49"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="403"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="18">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDM19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000228701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53883" checksum="7EAD3CA3205933F7" modified="2016-01-20" version="1">MSIYMDDLCDEYEEISLSGCSYSDRTKALCHKYENMIDFSMINRDQIRDKGDRATTEHALDKRSVAILYKMMSQGEFAVINGCISTGKEANVYHAINPKGDLAIKVYMTSILPFKSRSKYVEGDFRMRHGYSTCSSWRLVSKWAEKEYRNLLRINRAGSIPAPAPVKLKGVVLLMTLIGKDGYPAPKLKDVASGDWSEFGPPPDWPAIYRQILQNVRTLFQKCRLVHADLSEYNLLYMDGQAWFIDVSQAVEHECEQALEFLRKDCYNVNAFFRRQGVSTLTLREFFEWVVDPTLSEEVEEASIYLDRLLTRAETRGFNRTLEIEDDAFRRVYVARRLEDVKRFFSDFKRLKMGLIKPEDLYYTAVTGVRPELPGEGSAGKAVQVGNESSEQECRGKVVMELEEEGESRGAGKESEGIRVPLRNVSRRPRDESLASKRSRKKAVQAEKAEKRLTKIPKHVKKRAKKIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNL9</accession>
    <name>A0A0R3WNL9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2344</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000981">
        <property type="protein sequence ID" value="VDM19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNL9"/>
    <dbReference type="WBParaSite" id="TTAC_0000235701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000235701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000235701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000235701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5284" checksum="643F6DE124F54726" modified="2016-01-20" version="1">MGEVQCDVGVLEEEKEEEKKKKKEEEEEKKKKKKMKEEEEAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNY2</accession>
    <name>A0A0R3WNY2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001103">
        <property type="protein sequence ID" value="VDM20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNY2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNY2"/>
    <dbReference type="WBParaSite" id="TTAC_0000247001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000247001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000247001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000247001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="53014" checksum="D9BDD5935B37BA3A" modified="2016-01-20" version="1">MNDVFVKAMSLSMNQPLSDSVRSLDGSSNDVVAAAGSLKSLQLRTVVTPAPPPTEVGASGDVEIIQLLKSLLAETKAQAASIKTLTNKVHENKNQLTKLANVQASILRQVNALNPTLTTPATPTSPTWAIQLVDQVHKQKLETAKQLTHLETMLNNIQNSAASKASAKKPQTTSLLDAKQMQSLQDHTRNAMRTEMQNIFKSNIPTILEPLRQHLRSSLEEMLSPLPKTVADRMLSVIVDPKFAQYFSGQMSSTIAPSMTIAYREEIRRVLVPAFTKGIDKLTKELNELVSNALNQHIQLVVTKMDSGVQSSRDKIDASARKFDDHVSQLSMDIAAVTVQISELLKVSSSKQQPQPPAPDIAMSPAFAATGAGLSASTPRDLSAKAPRSAFDVAGGGGSKQQLRSFISAGTVSTDPYQSALMFIQNHQFVDALEMALTSANQTLLLKVLQNVPVVQLFRQNVKQELLLSLIHQLSCGQLQEQLEMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPF3</accession>
    <name>A0A0R3WPF3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2628</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
            <location evidence="7">COPII-coated vesicle membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001303">
        <property type="protein sequence ID" value="VDM20714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPF3"/>
    <dbReference type="STRING" id="6205.A0A0R3WPF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000264301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000264301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000264301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="9">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM20714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000264301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25248" checksum="32D40D1471B62931" modified="2016-01-20" version="1">MVSMSEYIQQTEASDGIRFSWNTWPASRLDAAQLVVPISCLYTPMKERENLPPIMYDPVVCTRCRGILNAFCQVDVRSKCWNCCLCSSRNTFPPQYAGMTEQNLPAELMPQFTTIEYTITKAPTPPPIFLVVMDTCLEEVEFNALKNAIQQLVATLPPNCMVGLITFGRMVHIHELNSGPIAKSWVFKGTKDYAGDQIQGMLGLGRSGISGRNAGLPATQVVPGGLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQB2</accession>
    <name>A0A0R3WQB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001702">
        <property type="protein sequence ID" value="VDM21555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000295201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000295201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000295201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000295201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54321" checksum="55F4CFBCA567E23E" modified="2016-01-20" version="1">MPITIRQRIVEYELCDMVTEIDARNWNDIREVASPITGLFAPVSFAVRQGWIQLGGTNEYIDPTTGHTIPLETALAQGRIRFSNVASTNGNFTSSLVFIERESAVREKADVTFVLNTVNREYIPIRKAQSDGLVREDDKQITWVLDSLCNKWITAEEAISQNILKVDKIYDQESDEELMRRQQQSVVRAYHVTAIKPGGEPCEWLRPEDAVRLGLFNRQTGDVAVDWPSRPSYKPEASEFSVSQWCNFLTARKAGWIRVIPEMNINKWIPLSQPSGSNGNRRLLSTSVSLLSSRAGILNHSHSDTYKLNDYQRNGRTQPVFRQFRFYTPGTMSQHQHRSYSHSPEYGTESSRTPPYLNEVGEFEHSDVYALSSSIQEQMETSEEQLLHREHNLETSRTLEEGDIQFYSYPTPSYPSNVPISTIRHEFEEVHAYEDQSSTWSRSRQYVGEVDEQTRYSRCAQFSQYTDSDKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQR7</accession>
    <name>A0A0R3WQR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3092</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001912">
        <property type="protein sequence ID" value="VDM21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000310701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000310701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000310701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000310701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14411" checksum="5E7A3A6D35DC11D8" modified="2016-01-20" version="1">MNVPVRPNIDYLQHKEGSKNLTHMQAIELHINGKQFYNDHLVVGIQAVTFVRPSFLPPLDPPRRLFERVESQALFPMWSSSIQSCGKAIATGADIESPNTSTPPPSPPPPPPPPPPVAAATAAVLSGWVYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU5</accession>
    <name>A0A0R3WQU5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3120</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001955">
        <property type="protein sequence ID" value="VDM21997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000313501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281863at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24050" checksum="CD71568CBB279E72" modified="2016-01-20" version="1">MVVFTFISGLCGLLKSLLAIAFFILGERKVLGHSQYRKGPNKVGFLGSFQKAHIFDLIGVMLLVVLSAFYCFVYGDYYGSKIMWLCCTMYLLRQFYNYSFSSSIRCRFRGILCTPFDYGEAERELIGVVLFLGEARATLPRVRYDFFVRFFWEIGLLMIIFSKYDYCFCCGLLKRNIFIVKYANTGVLCIGVLGVLYIFMYIVSWFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQX7</accession>
    <name>A0A0R3WQX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3152</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001991">
        <property type="protein sequence ID" value="VDM22056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQX7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000316701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000316701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000316701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855429at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132953" evidence="3">
        <location>
            <begin position="20"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000316701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67005" checksum="2B19B098ECF9A04A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRA9</accession>
    <name>A0A0R3WRA9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bravo_FIGEY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3284</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002185">
        <property type="protein sequence ID" value="VDM22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRA9"/>
    <dbReference type="STRING" id="6205.A0A0R3WRA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000329901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000329901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000329901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133038" evidence="1">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000329901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="63033" checksum="A31FCFD3F3AF2DF8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS11</accession>
    <name>A0A0R3WS11_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3536</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01002603">
        <property type="protein sequence ID" value="VDM22826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS11"/>
    <dbReference type="STRING" id="6205.A0A0R3WS11"/>
    <dbReference type="WBParaSite" id="TTAC_0000355101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000355101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000355101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000355101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32457" checksum="D580992289D861CC" modified="2016-01-20" version="1">MDVDVPSLISWLLSGDKELQITSLEYLCNALLFTDDRGFVNKLDTTAIINALLLLFSEDNAPDDVLELNARTLLYLLEMLDAPALRNIKIKHYKILCMRLDIADLSSSSGSELAQRIIKLLDFITSVEAGKPYFGGVLSSVLRFVRWHSEEVHADVIQSSMNIIHELCRRCEPGDKHMPEWMDSLSDLLSHNNYEVVVKKALQSLGCIFERFSTSGRDLSSIATNELITRLSHHLYKACGVFPDIRAPGLSLFYYPSFLEFATSYSPRQEDTSCKLDGFETMGFFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS24</accession>
    <name>A0A0R3WS24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3549</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002625">
        <property type="protein sequence ID" value="VDM22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS24"/>
    <dbReference type="STRING" id="6205.A0A0R3WS24"/>
    <dbReference type="WBParaSite" id="TTAC_0000356401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000356401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000356401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000356401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14242" checksum="C4CA691010955E42" modified="2016-01-20" version="1">MGFLLVFDLTNEKSLLSCREWMNLLCQHAYCERPDVILVGNKADKTEERVISTSDAQRLAQELQVPYIETSALSGKNVSAAIDMLLDLVMKRIEESVTKTRVHKATKNSNGGIHLENANSTKNKSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSK3</accession>
    <name>A0A0R3WSK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3728</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002939">
        <property type="protein sequence ID" value="VDM23235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSK3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000374301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000374301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000374301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000374301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15618" checksum="7BE670F6FFE97261" modified="2016-01-20" version="1">MSDYDRLKVIVVGDSGVGKTAFVHLLCYEQVLPNPSWTVGCSIELSIFPRPGSTDNAINRMGHSRTLNGERYFVEFWDIGGSANHANTRSVFYDNVHGVILVHDLTNKKSEANLEKWLIEVTSKGRAYVNNSLWIFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSY2</accession>
    <name>A0A0R3WSY2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3857</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003171">
        <property type="protein sequence ID" value="VDM23582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSY2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSY2"/>
    <dbReference type="WBParaSite" id="TTAC_0000387201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000387201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000387201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000387201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22064" checksum="FB2AD9304AB80E25" modified="2016-01-20" version="1">MAHNALWNFPCGYDNVAVQGNANKTLYSSSEDCSVKNLANISRIIGQKEIKNDRFLTAVGTLSSVANMLGRLMWGELADRIFYKASTLLAVVYAIWSLLFLVLPFSPHVPNVGIYLFAILVILLFICIAGLFVLTPYAVRKLFGQEYFAANFGLIFSAVNLFTLGRLWLCKCVHQSRVVDLMSSTESTFTLSELMPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTD3</accession>
    <name>A0A0R3WTD3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4010</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003470">
        <property type="protein sequence ID" value="VDM23974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTD3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTD3"/>
    <dbReference type="WBParaSite" id="TTAC_0000402301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000402301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000402301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132992" evidence="7">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Netrin receptor UNC5A-D-like N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM23974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000402301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24228" checksum="D91978730661CF6B" modified="2016-01-20" version="1">MVESYRTATFTLLLICLIYTGAGDASHQKDLIQPHEKHLEGVPVFIQQPESTYYAWRGKPAVFECTAEPVSHAVVFCADKTFPYMGNEHTSEERLQVTRLDSNGNLDADGPRWHLSLPVRTKDLEEWFDAYICTCEVWNLIPALKQVKKVFSRNATIIEACKLLTHQKLSATSYFAEAAGNKQACQHRLRQFICILRNQPKFTVNGNVGVLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH3</accession>
    <name>A0A0R3WTH3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4047</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003559">
        <property type="protein sequence ID" value="VDM24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000406301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37432" checksum="3A26BC6215B95219" modified="2016-01-20" version="1">MLTPLFSLTQTSDKLILKLHIPLADLSNSEFLVEDGVVFFGAPPYYLRLGLPGSVVEDDDHIEFKLESGDMFVTMTKLTPGEHFEDLDMLSRFIINSDSKKSASNVGIQILDSTTTLPEGTVDYDWFVELLEENDAARSDDDPMNVEIIKYPYGFAASKSGLFVDKPETCLPIDLPNPDFCPPSKRHRLQLQSVQDHFQAEHYIADYYETEASANALRQSIPWTEDKTGAPEFSDEYRHRLTVLSTRALPLLPPSPSDIGSLEKVKVEDTRTFVYLGLADLLFAYTYDYRVREGDENCESGWVVAKIASTLSWLEASFTQLEHVTRFFVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTT7</accession>
    <name>A0A0R3WTT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like_fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003810">
        <property type="protein sequence ID" value="VDM24329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTT7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000417701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000417701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000417701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6231442at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000417701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11266" checksum="42B7C6785ED53994" modified="2016-01-20" version="1">MELKYTRSGELDFFKNAYEVGSHGRLLFKVYFNAKPEVIAIKTDKNEQIVWPQSLELVGGFIPLRIQATITSNDVVPSSRVREDSGHPVFEGAAEVFGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTX2</accession>
    <name>A0A0R3WTX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NOT2_3_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4197</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003890">
        <property type="protein sequence ID" value="VDM24406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTX2"/>
    <dbReference type="STRING" id="6205.A0A0R3WTX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000421201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000421201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000421201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="296"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000421201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="48761" checksum="09FC3E2D02DFF326" modified="2016-01-20" version="1">MGSMEHLLGLESAYAQLALCAADKANSLLMGASRAGVSGERSARCGNMATKTRGPCTRCSSGLVFNASDFPPIDGCTNQSKGQSRLHAGQRSNQVSTTARSSAGNAATACSSRIGGPARGGGGGSGGNKGNRASSTTLNEEATTKFSMEKDFPALPVGQKPTPSPPPPPPPPPPPPPPTSNSASSPSPSSTTTAVTTQSTTTATAPTATNTPSSSGRDAHEKESTSVTAEKSSHTVQLLPNHYITGIPNDMVDNQFGMLGLLKLTEIEAPLGAFAPGMRLSRENFDNLPPPGELHSSFASPLDDRYTLPPHETECDVPPEYRVRHRLGRRLPADPPLQHLTNQILFWIFYSLHGEEAQLVAAKELYNRNWRYHKTKKWWLTRVPGTKVIRQGNTEQGTYYCWDPVAFKQVTQHLTICLTDLDDTPTTYQLSSPTLNATVHYLPSISHHQPNLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU49</accession>
    <name>A0A0R3WU49_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4274</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004057">
        <property type="protein sequence ID" value="VDM24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU49"/>
    <dbReference type="STRING" id="6205.A0A0R3WU49"/>
    <dbReference type="WBParaSite" id="TTAC_0000428901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000428901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000428901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM24578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000428901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18903" checksum="4F669FBE8433B998" modified="2016-01-20" version="1">MLSHSTAILRSRLVRTIYCPYLHLSSSVAPQVPLWFNVAPKRAHPYMELARLDKPIGTWLVSLPSTWSIAFAANPGCLPDFGMLALFGAGALLMRGAGCTVNDIIDRDIDLNVLRTRDRPVARGSVSVSNAAKFLALQLLGAFVILLQLSPQTVFIGSCCLGPVFAYPLFKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUM0</accession>
    <name>A0A0R3WUM0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4445</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004453">
        <property type="protein sequence ID" value="VDM24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WUM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000446001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000446001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000446001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8020218at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="6">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000446001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27496" checksum="7D6AC3FB1FDFE520" modified="2016-01-20" version="1">NITYLRRKYPIRVPQYVTANGGTQELTVEQQVYIEGKKDDEEPIIEVLLRDNVSGLGPKGSLVRIHRNRFWNNLYLRNLAELPTPERVHELKSEARYDSLTDPNILFGHSYETQQRLLNMTLYIPMNPAVPWTLTTKHVKVAFRRIGVVVKEEDIALPDEPVTASTLEEFTVNVNIENKVLVPVKCRIFLYQRLDAKTTTKPPSNAFRKIRLDDWMSDFPEDELRLLPGFTNAPYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUM9</accession>
    <name>A0A0R3WUM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004480">
        <property type="protein sequence ID" value="VDM24990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000446901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000446901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000446901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254784at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000446901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15600" checksum="60D3EDE3299E2FFD" modified="2016-01-20" version="1">MGTVKETITETLLVLRSDWLKGVLKSLLSPSAPVRKTTVKIMRATCISLLTLFYFASSLRLHGLDGPVDPAVSSTMAVGESEDDTDLLLPSRYRLAKRYPLLSDYDEDMILGNPYLAREISRRSPQFAWRPHSRFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV03</accession>
    <name>A0A0R3WV03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4578</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004803">
        <property type="protein sequence ID" value="VDM25222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV03"/>
    <dbReference type="STRING" id="6205.A0A0R3WV03"/>
    <dbReference type="WBParaSite" id="TTAC_0000459301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000459301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000459301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="104"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000459301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21608" checksum="41CF3504AFF7F96E" modified="2016-01-20" version="1">MMSSLMKEMKFYISLAYGALACKLGARTWYDRINDKLVLGALPILPEWDTIRLKEGISHVISMVEPFEIKSFVLGPGEAADRGIRYLSLPVKDFVGVPTNDQVDAGLDFIDSCQRPGDSVYIHCKAGRTRSAFIVTCYFMSAFDLPPEEAVAQIQSRRPHITFNSTQWRGLRNYFEFVHQRRQPRLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV28</accession>
    <name>A0A0R3WV28_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4603</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004865">
        <property type="protein sequence ID" value="VDM25262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV28"/>
    <dbReference type="STRING" id="6205.A0A0R3WV28"/>
    <dbReference type="WBParaSite" id="TTAC_0000461801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11182" checksum="4BAFE52A18BE36CF" modified="2016-01-20" version="1">MVCEKCEKKLVKIATPDPWKAGSRAAAVKGPRRLNENKLLTAKKGRYNPYSKAFRKCRICGQSVHQPEAHYCQSCAFKKGICAMCGVRLVNTTNYNQCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVB3</accession>
    <name>A0A0R3WVB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005092">
        <property type="protein sequence ID" value="VDM25448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000470301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000470301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000470301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000470301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="12937" checksum="44E2499A4809BEEA" modified="2016-01-20" version="1">MLTLALPPSLIHFIEGARNQPLSDLIQRDRNLPPPPAEAHRFIADPTGHNAFALYGEIYGANKFPNQGSGTRILHFYIQGDIEDVEQLSKVMWDREDQNELSRDGGGGGGGGGGGGGGGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVE3</accession>
    <name>A0A0R3WVE3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4718</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005164">
        <property type="protein sequence ID" value="VDM25515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVE3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVE3"/>
    <dbReference type="WBParaSite" id="TTAC_0000473301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000473301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000473301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM25515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000473301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="22491" checksum="1F678688F373A8AE" modified="2016-01-20" version="1">MGGVSDDIELNNPADGGKRTAVQMKKEIGVIQAVSIIFGVIVGSGIFVSPVGVLRYSNSVGLSLVMWIVPGLFSILGALVYAELGVRIQKSGGEYAYILEAFGGLPAFIVMWITFVVIGGVSCAANSIVFAEYMLQPVYPDCAIPGPVVSMIALCGLSECDDGVVRHFFSVDMRNKLLQGEVGGATSSDIFVWQGDCAAVDNCLWIVLPCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVS3</accession>
    <name>A0A0R3WVS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4847</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005476">
        <property type="protein sequence ID" value="VDM25759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000486301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000486301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000486301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10455402at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000486301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13680" checksum="66ABD04E28458770" modified="2016-01-20" version="1">MFAVPVNNVSSLLIMNSSYSPRSIDPQKPLSIKVDEQNTKVQIPYLPPSPSMIDRARPGRAVLVNSTLDSVPPIISSPLPSSSLMRFINSSVFSVIHTLHYLDDSSASEYRSCLVFNLKLSMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW83</accession>
    <name>A0A0R3WW83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyco_hydro_38N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5008</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005939">
        <property type="protein sequence ID" value="VDM26058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW83"/>
    <dbReference type="STRING" id="6205.A0A0R3WW83"/>
    <dbReference type="WBParaSite" id="TTAC_0000502301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000502301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000502301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000502301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13577" checksum="D3CF29B1195C586B" modified="2016-01-20" version="1">MDGWMDGVEKQGCIAPPSLLGQGLPFNLQVAYSFEDEYLDPTYIDGLRRHHLSQLIVELSNQEAEYGHTRPLPKQVRLVEGVIFLPFQFTVSPHYWEHKLTDYLRLGLQAFTLFTTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW90</accession>
    <name>A0A0R3WW90_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5015</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01005957">
        <property type="protein sequence ID" value="VDM26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW90"/>
    <dbReference type="STRING" id="6205.A0A0R3WW90"/>
    <dbReference type="WBParaSite" id="TTAC_0000503001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000503001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000503001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000503001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21897" checksum="3D0C24248BA6DF5C" modified="2016-01-20" version="1">MFLIVTEAYVTLATNDEYCCGALVLADSLRKVGTTKKLVCMITTCVSDNMRTALEAFFDHIELVDVLDSSDSENLKLLARPDLGVTFTKLHCWRLTQYSKCVFMDADTLSFIVSMDNIFLVRLTSFSFTLHHFFLTPYQVLQNIDDLFEREELSAAPDPGWPDCFNSGVFVYTPSLDTYRALLDFALSEGSFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWJ8</accession>
    <name>A0A0R3WWJ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase RNF128</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5122</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006313">
        <property type="protein sequence ID" value="VDM26311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWJ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWJ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000513801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000513801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000513801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000513801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="32978" checksum="886403A47CD990E6" modified="2016-01-20" version="1">MNIPTAVVIETPVGRTAQAAILDHLIDSMSSRVISHSRISQQQQAEGQTEASREPHSHVRNTASSGNSQRSPSSLLTGLLPSRHGDTFLPCNSRHFSGTPASAFHIPVRRRRSYVGSASGGGASTPRRQSIGTAARRGRSAGAQIGTNSTTSVQAPSSTTSTYTSRPPYQSFLRSMATAVSSSGVNAELFNRAIGDVTNQLTQLVAHGIGSGFSAATASTAGSTTVGPFTWIINNPQNGGVQFIPPPQFFFHSTTGGGASQSGPGVRFSMLPGLLVDSLIRSMWSFIIELARGQLSPESLRKQISQSIVYVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWU7</accession>
    <name>A0A0R3WWU7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5221</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006664">
        <property type="protein sequence ID" value="VDM26513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWU7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWU7"/>
    <dbReference type="WBParaSite" id="TTAC_0000523701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000523701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000523701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM26513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000523701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30648" checksum="4860E6E910E4F7B0" modified="2016-01-20" version="1">FSITAYFPEGQSTSIVGRVGCGKSSLLNALLGNMELVSGRINIKGRLALVSQQAWIFNATLRDNILFHRPYDPERYAKIIKACALEHDLKLLPNGDLTDIGDKGVNLSGGQKQRVRACYADADVYLFDDPLAAVDTHVASHLLKHVLGRGGLLGGRTRIIATHHPSAIAASDRVIVLDSGRLVEYGSYASLSRRHTSHLNAFLHSEELRQRLMSESEVASESRPPSAAAAASEISVPSSHRRRRTSTESHPSSYVPPSDLADLALMEAESSDSRGNGDAEPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXD7</accession>
    <name>A0A0R3WXD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WSN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007400">
        <property type="protein sequence ID" value="VDM26922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXD7"/>
    <dbReference type="WBParaSite" id="TTAC_0000542701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000542701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000542701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000542701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44097" checksum="335BC309AEEACC9D" modified="2016-01-20" version="1">MDPKIVQIFLTKLPSLNKYATEMLTNMFKLPSLLPGMKMKHDDELPKAESFFSNEELEALRSQIPHIDEVIELVDPKKLSVLRVLIPDFQKYLINEEPAKINAINSHLVNVKFVIEKMKDGRVDTLLDKQLLKDLGLADPSIVNTLLTHFPSAKSQSTDSLLSQVKGKLDEAKNMVINAQTQMSPSEHLKPTDSFLTQVKDTLEAAQDMVSDISMQSKPSNQSKPTDSLLSAVKGTLNAAKDMVADISTQMKPSMQSNYPESLMSKVKGKLDTAKKLVANTPAKVLPSQQLNHTSSPPTQTNDTLDAAKDMVANMSTQTKPSNQSKHRDSLESKVKDKLEAEKDLVEDESAEVVPSQHSKPEFPLLPQIKPLEASQVGESIRDFFSKIAKPFQQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG5</accession>
    <name>A0A0R3WXG5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP-ZIP_m domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007519">
        <property type="protein sequence ID" value="VDM26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG5"/>
    <dbReference type="WBParaSite" id="TTAC_0000545501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="40534" checksum="768D8D18F11F36F1" modified="2016-01-20" version="1">MTEVSSEPKVVETSARHSEDGSTNPTWKLNEDENNCLDVYQNPEGAVSPEESAITPNVVQSKGSPTHDTGAIGDRGIHSPEVHQDDLQPQLRSEVSFTSTGATDPPLSSDMEHFGGTPTTNVQESGVERKNPSDVSSTFETVAKSETPPPPPPSLQNLKSHCPPPPTASTNAHVTPKSDDLPAGTKLSAEVIPTTKSEFSLQVSKSPPINPIAPANRGNNKAAIDIKPLQEDDKSKPQSGGQESGEEILSFKERLKLFEQRCTTSHPQFAVKAPSADGVKSSHQLNEMKQSVDEKSNEGSKIAPQRTTVTATASTKTSSSSPKSAPRKDEHSEVQDSDSDSDSDDDDDSDSDSTTSDSGDNDKEDKEEEEKERMMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXI3</accession>
    <name>A0A0R3WXI3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5459</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007626">
        <property type="protein sequence ID" value="VDM27039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXI3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXI3"/>
    <dbReference type="WBParaSite" id="TTAC_0000547301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000547301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000547301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000547301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7048" checksum="2AEB43F4E5512C4E" modified="2016-01-20" version="1">MSSDADRYVNTLLDLFNRFSSMIEECFHNDPSFLTIRDKAYQRLVNDTTIFSVKIPDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXJ3</accession>
    <name>A0A0R3WXJ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5467</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007649">
        <property type="protein sequence ID" value="VDM27054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000548301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000548301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000548301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000548301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15972" checksum="AEACAFFA54639D82" modified="2016-01-20" version="1">MPNYCLNGGRCVNKAQDEEDALDTTTMPICICPPTRMGARCEIFRSPPLPTPTSTIATTTTTNTTANPPVAANSSAINRPSDHAISETLRRQPKNNVSLARLSKDNGVILRSSGALEQSSPERATSSTSRYPAKKEKGLDIIPNCHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY00</accession>
    <name>A0A0R3WY00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008272">
        <property type="protein sequence ID" value="VDM27340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY00"/>
    <dbReference type="WBParaSite" id="TTAC_0000564001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000564001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000564001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6293304at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000564001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21826" checksum="EDA3019B9064D09A" modified="2016-01-20" version="1">MSRLSLVCTQTTSQRTLTDLPTIVALQICEYLDAADLVNLCTTVPRWKAFLTRRRFIHVMKQHIRQWTWFDKRLCQLLLPHPLNASIENICEAIMYRSALTKSFHRFRNRLALYRWQQLQLQHHHHHHHQHQKQDDDFVNIDVYPIHVRDYLHNGIERMHRAVLRGALPARFPFHRNLHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYV2</accession>
    <name>A0A0R3WYV2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS5926</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01009765">
        <property type="protein sequence ID" value="VDM27986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYV2"/>
    <dbReference type="STRING" id="6205.A0A0R3WYV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000594201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000594201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000594201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM27986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000594201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26836" checksum="EF0AD95D979D8C14" modified="2016-01-20" version="1">MQHQRDLNPHTKLGVVFSLGLPRQHGGRIFNRDGHVIILRGPSGDLIEEYTNRGSEVLQKIEEEIEKYDDIVLTDYEDTYYNLTWKTVANLRWLSGFCDKVHNDVFMILDDDHGMNLTRVMDFLASMPKAKKRTSLFGYIARWDGATRNPLSKLFLSHREVPWNLMCAYPRGFCQIIGTDIIDDMAIGSAYTRHNYLHEDVYLGLLTFKLGIPLHHVDTMFSESMKPTPGVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZN8</accession>
    <name>A0A0R3WZN8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6260</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZN8"/>
    <dbReference type="STRING" id="6205.A0A0R3WZN8"/>
    <dbReference type="WBParaSite" id="TTAC_0000627501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000627501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000627501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258888at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
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        </location>
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            <begin position="481"/>
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        <location>
            <begin position="509"/>
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        <location>
            <begin position="574"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="VDM30445.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000627501-mRNA-1"/>
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    <sequence length="975" mass="106426" checksum="089087D6D2B859BF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X075</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="VDM30704.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000650201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20585" checksum="99EAB7F70BAE7435" modified="2016-01-20" version="1">MALVSKGSAFLRASPPLLSQKNFAYWHADWKPKPFPTTPAAREAAAKKYGLLPEDYETYEPDGNCPGDYPKLEPFNELHRDPYEHYDYGHLKRNYNEPIPWCWDFFGPMGYDNYQQQLRYNEPRWRTLLKLITPVLIVFPLSYLGDMYKVFKPMMPKQYPFDGHDNYTFEPANE</sequence>
</entry>
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    <accession>A0A0R3X089</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="2 3" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000652301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44766" checksum="FE9183ABB6EF0AB4" modified="2016-01-20" version="1">MSSSRNYGSLRHGSGPLAAYTRSVTASRTGGLADRYLQNANRSTDLSRYGNNYNTTPTRTNEIKTRFENGTSTSSRKADDINIAPPEERPRISIGGRYLQRVNSRDGTNEASVVPARSSWRESVYGVQYSNKEATSSPTSKSSANLTETERRRAEREKQIQLDKVKQQMLEEEREERRLRQALRKATLEKDEAKIAEVDAQIRRLQLRRQDSKKKEREAADSNNLSQKLSYKANEKTAEASVSGRTKKSDVVTVPDIVQTAMSFTDFDEYLRNHLIGGRDNGESWWIYQPDSETEDSVAEMSIVYKTKKAKELFTSMPVELQHLVVRAHKRPIRFAAIMEMCKTDKHRAEFSAESERNFKGYNDVKTMLSDFGFDLTKVSRWLSISFVRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0I0</accession>
    <name>A0A0R3X0I0_HYDTA</name>
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        <submittedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6625</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
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        <property type="protein sequence ID" value="VDM30859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X0I0"/>
    <dbReference type="WBParaSite" id="TTAC_0000664001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000664001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000664001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10004439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133085" evidence="4">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="182"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000664001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53834" checksum="EFCB0595522E9ACC" modified="2016-01-20" version="1">MWLQPLLICFACLFGIAAHGLELTLQPDELVKAQRESHGGFYFYDSNGATLMFNRSLFVYRENIYDAWSRWSECSPHTCLEHRYRRCIDDSYTQPVNYLTTSARVCPFKYIAEERPCEDKTNCIINAKPSKVLIEMQEKCGNRGSFDAKTPKPKRRKSKDEDDESEEPEQYAPEMPLYSLKILGGKSAKSKSWPWHVGIYKAANYNASEGLTRLKSENIICGGTLITPQWVLTAAHCLKPIFGSSAALPFGIPTPLNTPEMEPISLLVRAGDTVLEGTRTRNEQESDHVVDLVVIHPDWVAQRVNSPFDIALLRLETPVDIESGGVGVACVPKEADATPAEDAVCFSVGWGENDRPPSKPRHRRPAFFNPFYWPFGRLWERRSQRPSTLREIKVSIDPPEKCFHHDDENDAQICAGSSNKGVCAGDTGGGLFCRNEEDGRWYVYGVMGSGPTQYCKTRRWLYNSVGSVIQWINRYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X181</accession>
    <name>A0A0R3X181_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tripartite motif-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6924</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020332">
        <property type="protein sequence ID" value="VDM31208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X181"/>
    <dbReference type="STRING" id="6205.A0A0R3X181"/>
    <dbReference type="WBParaSite" id="TTAC_0000693901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000693901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000693901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000693901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="782" mass="82354" checksum="08F14A6838F67DFA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1P9</accession>
    <name>A0A0R3X1P9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XRCC1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7140</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020348">
        <property type="protein sequence ID" value="VDM31474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1P9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1P9"/>
    <dbReference type="WBParaSite" id="TTAC_0000715501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000715501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000715501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein CEP104 Zn finger" evidence="2">
        <location>
            <begin position="745"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000715501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="904" mass="102668" checksum="61C8487F7CE619F1" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Z7</accession>
    <name>A0A0R3X1Z7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7256</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020357">
        <property type="protein sequence ID" value="VDM31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Z7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Z7"/>
    <dbReference type="WBParaSite" id="TTAC_0000727101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000727101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000727101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="160"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="416"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="641"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000727101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="728" mass="79595" checksum="C6D65183CC2C6561" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X211</accession>
    <name>A0A0R3X211_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">18 kDa Sin3-associated polypeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7275</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X211"/>
    <dbReference type="STRING" id="6205.A0A0R3X211"/>
    <dbReference type="WBParaSite" id="TTAC_0000729001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000729001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000729001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000729001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16632" checksum="01CA11A0E80BCAC2" modified="2016-01-20" version="1">MLYHRLDATLLELSSLVKIVNPDARKRGTIFDFAIVSPDPRSPGYKMRDIGSVCSGFPSDSDKIMLKDCAFRIGDMVDVAVTPPATERTPVGGGIGSNKRRVVRRNPEPLVNASATATGAFQAEQPVRRVVGRDYDSYHYYHSRQRRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2E8</accession>
    <name>A0A0R3X2E8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7446</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2E8"/>
    <dbReference type="STRING" id="6205.A0A0R3X2E8"/>
    <dbReference type="WBParaSite" id="TTAC_0000746101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000746101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000746101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000746101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31866" checksum="CA39B088AFC91927" modified="2016-01-20" version="1">YAPWCPACNLVAVEWRRFAELAPHHDVKVAQLDCSAESAVAMIFTITSLPTIFHVKDGVFRIVKGKRKTEQLLDFIKNREFELIEPTTWSIPPNAFYMSAVVRFLDLCLSITVRVIAASGFGTLIDLKAHRMMIGYGVPASLSIILVGTGVLASGAAIGMLILCVCEYFCPPRPQILNVVGMEGDPPQPIVTKETACRISLSVSFSLKGTSSLRLPKIRFELPNLCTALNSSFDVITAQIPIVIGASKDMEQDSVLDDSEDSSWTEVKAPDAKDCGQTDEPLVLHRRNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Y8</accession>
    <name>A0A0R3X2Y8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein GEM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7667</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020393">
        <property type="protein sequence ID" value="VDM32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Y8"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Y8"/>
    <dbReference type="WBParaSite" id="TTAC_0000768201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000768201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000768201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000768201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="510" mass="57092" checksum="17799B6F81AF4AE2" modified="2016-01-20" version="1">MPGNSKTLRLREVFRFRSMRRHQEMRKGQAGDSSAMRESNDPDDSVPPLSAVPIVCVQCDPSVDVEDDEFERDLYRVRSFKRTSKGLISLGDSIRSSSTTKYNHSFHTPRCSTTSAIVSLGRRSRRSESYAHASNFSAQRQERHSTAYESVRANLESEHFFSHYKPTSPAGSLRPPSTFSLSNIAIPVKVQILGGPTVGKTMLCRQFLTAEFMGGKTESFSEDSVERFVVIEVDGWNRSLMLIDNIREEAAEEVHSAEASLAFFPPTCNTLEEPNHRRRATSATASNTGLKDKSESQRRKSSFCNPKAEIAALDKKTQYESSSPLECSHLAMRPQVKLEMRILDVDIYVVVYAVDEETSFKTAKSIIKKLQEMKSANCKLQLLYLVGNKTDLVRSRQVTTQRGRKFAAANGAIFFEVSAAINHLVDELLVDMVVQWRKEVTQHEFSRLGFPMHPSTPAISGAAGGAATSSSFENRGRQSWTSTLSNPKNALQRIFKQQFTAKSCMELQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X485</accession>
    <name>A0A0R3X485_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">TTAC_LOCUS8193</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020461">
        <property type="protein sequence ID" value="VDM32705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X485"/>
    <dbReference type="STRING" id="6205.A0A0R3X485"/>
    <dbReference type="WBParaSite" id="TTAC_0000820801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000820801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000820801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000820801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43266" checksum="A5E09F0BD8580700" modified="2016-01-20" version="1">MLQPTLKLVIRFQPKEFAFYGKRKPIQCWVPQEFKHPWEEYAENLCWIQNTYFLLPNEDVPEDDFELHRVKYVGYYQWIVIVLAGQAMLSWVPYLVWRVGSKRLPILLRSAREAAIPDRELRQKAVSCLVATLEEISESTARQKRVKSSLKRIFCSIRPNIEITLLFFFVRCLFIGNSVGQIYLMKHFIGSNSSYFGIDMLNNLIAGRDWETTGQFPRVTYCTVNVRKMGQIKPASYTLQCVLPINYFVEKIFVFLWFWFLLLGAFTAFSTLQWAFNTLVPVRRIAYIKQYIRAIRQLSNTEERDCTRFVNNNLGPDGVLILQVVSRASSDLIALDVTATLWNNYRHAKITGTEEDFSRFIENVNRGTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X492</accession>
    <name>A0A0R3X492_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OB_NTP_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020462">
        <property type="protein sequence ID" value="VDM32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X492"/>
    <dbReference type="WBParaSite" id="TTAC_0000821701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000821701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000821701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252106at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033045">
        <property type="term" value="P:regulation of sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032245">
        <property type="entry name" value="RMI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962:SF1">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2 RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16100">
        <property type="entry name" value="RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000821701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19611" checksum="1E17E077118C1343" modified="2016-01-20" version="1">MSREAPPIMRKLLIGQLSRIQYGFTTTKEGVLIHYVPFLPRRRLLFSLVWLQGYALETSNPQSPVPLFLLDDGTGSILVTIRPDMDLPPIGTYVSVVGELEQVPTTPQDSHVSRSPSLTTYRLAARTLMRLSLMDKYFIDEDVTQKRAPSSAYAELAWPMEVMDMSQMFFTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4X3</accession>
    <name>A0A0R3X4X3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XRN2-binding (XTBD) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020511">
        <property type="protein sequence ID" value="VDM33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4X3"/>
    <dbReference type="STRING" id="6205.A0A0R3X4X3"/>
    <dbReference type="WBParaSite" id="TTAC_0000848401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000848401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000848401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2359216at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48430">
        <property type="entry name" value="PARTNER OF XRN-2 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48430:SF1">
        <property type="entry name" value="PARTNER OF XRN-2 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11952">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000848401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8931" checksum="5576ADDC347C7E8A" modified="2016-01-20" version="1">MTAREFEVEDMRRTHENPTEWKIRRAFLIKNTDVLEPERLVCLSNCFVNHELYGAGYPSRVMSEVTTSFELYPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X575</accession>
    <name>A0A0R3X575_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8584</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020538">
        <property type="protein sequence ID" value="VDM33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X575"/>
    <dbReference type="STRING" id="6205.A0A0R3X575"/>
    <dbReference type="WBParaSite" id="TTAC_0000859901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000859901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000859901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="207"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000859901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33121" checksum="E70DB3149F3C9689" modified="2016-01-20" version="1">MYPSDTPRRHLLRQEEQQEESPTSSNNNPSSRDTEETIGFESNLSTCTSVSHRPQAIDSSSSTTTSVTSTTIFSSSSSSASAYKTGKLGLRHGLVAQPGGGSTTSSSTEDSEARERRFGSIDLQHPLPLNTVTSGATGQEIVKGQLAIDAHMKQALLADFNLPSIFHSPAVLSTYFPRLLPTRSVDAFHLPNRLINPITASTTIGPYKMGRLLGRGNFAVVKLATHTQLNVPVAVKIINKELVGGQNLAKIARELEAMKRCYRHPNIVRLYHIMETDTNIYMVMEYASRGEVFGESVPYLIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5Y2</accession>
    <name>A0A0R3X5Y2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8883</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020616">
        <property type="protein sequence ID" value="VDM33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5Y2"/>
    <dbReference type="SMR" id="A0A0R3X5Y2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5Y2"/>
    <dbReference type="WBParaSite" id="TTAC_0000889801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000889801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000889801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000889801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24352" checksum="EDC76B1CBF53616D" modified="2016-01-20" version="1">MTADGPVAVKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLSFHTNRGEIQFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLFGDPNLEFVAMPALQPPDIQMDQNLAQAYELELQMAAQAPLPDEGDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X633</accession>
    <name>A0A0R3X633_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020631">
        <property type="protein sequence ID" value="VDM33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X633"/>
    <dbReference type="WBParaSite" id="TTAC_0000895201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000895201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000895201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000895201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8007" checksum="4319AF02E7531D6C" modified="2016-01-20" version="1">MDDGFFRRSDGRRERRGWVLSCGSLGSAWDIERCSVRLAYLLLSMALRNMMAFVVHLLLIDMNTPQMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X654</accession>
    <name>A0A0R3X654_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8960</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020638">
        <property type="protein sequence ID" value="VDM33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X654"/>
    <dbReference type="STRING" id="6205.A0A0R3X654"/>
    <dbReference type="WBParaSite" id="TTAC_0000897501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000897501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000897501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000034">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000010">
        <property type="entry name" value="Potassium voltage-gated channel subfamily B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="121"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000897501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="646" mass="74039" checksum="44B87CAC526DBE15" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X714</accession>
    <name>A0A0R3X714_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RF_PROK_I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9310</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020757">
        <property type="protein sequence ID" value="VDM34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X714"/>
    <dbReference type="STRING" id="6205.A0A0R3X714"/>
    <dbReference type="WBParaSite" id="TTAC_0000932501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51751" checksum="92D500D2F96706B9" modified="2016-01-20" version="1">MGVAVSAAKRAIRNWNSTNRALRHFDKVEAKRKAVLSSSKFGKSSCQYEEALAKKDADLEGRVASFDIASEGVKSSILPEGFNYVLKSSRKLPQRLEFGSPLPPPHLVFGFAVPEFIPEGKITMQQAVDMIRSYQLEEKTVFQLAEDYGLDKSMVSSPELDDGSDPVLREIAAQEFASRREAMRSLENQIMELLLPPDPTAKCNSVRLQLIAGAGGLEAAMFARDLFAMYEAYACHRGWRLASITDGGARESVVGADSPIHHVEVRVESSSPIDPVYPYLRWEAGVHRVQRVPLTSKLNKIHTSTVAVTILPVEVELDPEDLEWEVFRASGAGGQHVNKTESAVRVRHRPTGHVAACQADRSQHANRGKALQLLRAKLANEVARRQVETEMVEKRSQIGSLARSDRIRTYNYQQDRITDHRLGRSWSGLATVMRQGLPVVNETAFALDIAYKLAALASLDKPYFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8D7</accession>
    <name>A0A0R3X8D7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9797</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021055">
        <property type="protein sequence ID" value="VDM34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8D7"/>
    <dbReference type="STRING" id="6205.A0A0R3X8D7"/>
    <dbReference type="WBParaSite" id="TTAC_0000981201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000981201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000981201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000981201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="57070" checksum="86C3922878A0F5A1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9T6</accession>
    <name>A0A0R3X9T6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10297</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021518">
        <property type="protein sequence ID" value="VDM35277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9T6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9T6"/>
    <dbReference type="WBParaSite" id="TTAC_0001031101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001031101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001031101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022628at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001031101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45413" checksum="7FCEE5B45C345CAC" modified="2016-01-20" version="1">MPPSMLPAGPPAPPPPPPSCSLPSTPQAAQVLSPYTASRGADSQKLISHYRRSRSQYHPNPPPYRRPMPPPTESSKFCGGSISSAPELYTICPLPPSVSEPSDFGEEDVPFVKPPSATTVLGTPEILNEPEDQDEALIDGGDENEDTDFESFVVTGTEGEEVGAGDDDDEEDIKSAFLVTPQQSSCLEHVETSSTAHFHPSSTEQRRRMSMQSSLKLLQELVLQNQEKRIGRERKVVGSHQPLHQQHSHHLHHQKTSKAAVLRDGAALIRSQRATRDQLDAEITRLRAELDSLQESVNACCDKLPTSGVMSKQQVKSVKNGAHAWFHELVARRTQVNWKFYVFSLIFTDVFDTYCEKVWGSTSHEVLRRSTVSWLEDHCDLPQLRKCKSLSLLAFSQIIYRVFSFYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9U4</accession>
    <name>A0A0R3X9U4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10304</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01021529">
        <property type="protein sequence ID" value="VDM35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9U4"/>
    <dbReference type="STRING" id="6205.A0A0R3X9U4"/>
    <dbReference type="WBParaSite" id="TTAC_0001031901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001031901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001031901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001031901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="55263" checksum="C96B28409596A664" modified="2016-01-20" version="1">MRWHRRIGFGIWVIIVTIALISFKTSRNKPGSARVNEFGDRKPNMSSQQCRWPPWDPQESAQESVYNITLCVTLSPRFSSKKLSKRYPLTDLFRMSGPQRKVTFEDLSKLPRRFWRRVKYPNIYQTYPQDVPLKELVAAIKAGRPVSVVSLPSNVFEHARLKDGMTYFYPLKCTIPFYPKLPEYNFPLKILRTSNSVCTRNSQHDLVIVVKSAVHAWDMRAAFREFVHEQKAQHPKWKIGVVFSMGLPRHHGGRVFTREGHPIALGGRSGELADYFDGKISQTMEYVLHEIAHHDDILLGDYEDTYFNLTWKTVTNLRWLSAFCGQRNGDVFLVLDDDHKVNFTYLEAFLKTLQPDVKRTSIFGLIGRRDSAYRKPNGKRFLSYREFPWDIMAPYPRGFGQLFGADIVDDLAIGSAYTRYNYAPEDVYLGMLALKLGIQLRNVKDMYDHNDFKARHRTGKPVLVALKKYFDALISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9V3</accession>
    <name>A0A0R3X9V3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10313</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021537">
        <property type="protein sequence ID" value="VDM35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9V3"/>
    <dbReference type="WBParaSite" id="TTAC_0001032801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001032801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001032801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133281" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001032801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8881" checksum="BBB071DBD4B93611" modified="2016-01-20" version="1">MHRACFFLVAVCTALTTTHTLEEARANPELFKEVTDLTEFNPWYHAGIALVMLYILLTGITSSISIVAYILGHKSRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Y2</accession>
    <name>A0A0R3X9Y2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021573">
        <property type="protein sequence ID" value="VDM35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Y2"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Y2"/>
    <dbReference type="WBParaSite" id="TTAC_0001035901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001035901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001035901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001035901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28192" checksum="C63A6C171EB6362C" modified="2016-01-20" version="1">MTSELENGNLGVEVFVERLACLENTLQHVKCHLPSFYEHISAVPVKKALQSVVECIPPNAFTVSRRNSDLAGMASEEQAKIEFLLVKFMHAGETANDRALMRQPMRYSTFQNYVQLDGVKVSKSTLKLSKTSDLCECNQEYTSNRTIQAQISNSGRSLQKSLQLLSALEKAAQCFEEFPNTPVLKEEIVIMIRCLKANIMNLLRGIAYLNNHRRITRILAKLRQRGTVKTLLNRMEEEKGRKRAWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAN9</accession>
    <name>A0A0R3XAN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021924">
        <property type="protein sequence ID" value="VDM35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAN9"/>
    <dbReference type="STRING" id="6205.A0A0R3XAN9"/>
    <dbReference type="WBParaSite" id="TTAC_0001061601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001061601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001061601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001061601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="906" mass="100381" checksum="67CDE85E33EFED1E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAV0</accession>
    <name>A0A0R3XAV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022006">
        <property type="protein sequence ID" value="VDM35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAV0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAV0"/>
    <dbReference type="WBParaSite" id="TTAC_0001067701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001067701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001067701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5990676at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001067701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25794" checksum="8FCA41E8FA5983C0" modified="2016-01-20" version="1">MTLSSIKYGWFPRPTVIHNHRVRMRMKLGGTVGRGISPTYNWPPTSPETSLSYRWNLVTNLDKYLRPECSPHCGVGIILMDIQRQDQSVIQVEWALLPLLQEGLRDVTRNLSHPNLAPVANRCPQRSIQDLQRKLLKAPLYHRYSSPSASVSSPHQEYFSENELRQASWSSPAPQLVEHLDWARLGTTAVVAVDLIGSCFSPYWKGESGIRSSTILPTVNITTYIGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB46</accession>
    <name>A0A0R3XB46_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA_mis_repair domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10754</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022193">
        <property type="protein sequence ID" value="VDM35734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB46"/>
    <dbReference type="STRING" id="6205.A0A0R3XB46"/>
    <dbReference type="WBParaSite" id="TTAC_0001077301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001077301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001077301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="190"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001077301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54497" checksum="DDC0D57C929AEFBA" modified="2016-01-20" version="1">MSHIKVLDARSVNRLCSSQVVVTLGIAIKELVENSIDAGATKIGSKSHSTSKIHDFDDITKVNSFGFRGEAIFSLCQVADVTIHTRTEQAKVGTRLEFTNSGGLKSRRPLARSRGTTVYVERLFHTLPVRRRYLTNQSRLSREFSQAITLISSYCLVLTGVQLSCYRIDKKGTKILVVSNMEGNSLSSNIAAVYGQAQLESLVKITNDFAVNDELKDEYKVKLSAEELDEIKFSGFISMPPVGSTATFGRSSGDRQIVSINGRPCDFPQFTRLATDVWRRCCRESLLSKSQSLAMPSRSATSAFPVLILLVNLPRAKVDVNLSPDKRQLILHWERAVVMKLKAALTATLACVDGEQSTLNLQVSSVAVTARTELKSAEGLTQRPIVPTQLSLASNIPSRPESSPQNAKKPRLSTSPITSQRSIFTSDSARRNYNKRLPLLNRESVRVDFSMSRLLKYWASRGSLSESAETPSIGEFHADLTESAAQSELTSIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDC8</accession>
    <name>A0A0R3XDC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11538</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024767">
        <property type="protein sequence ID" value="VDM36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDC8"/>
    <dbReference type="STRING" id="6205.A0A0R3XDC8"/>
    <dbReference type="WBParaSite" id="TTAC_0001155501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001155501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001155501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257893at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133320" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001155501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22666" checksum="282D4C7556AA2159" modified="2016-01-20" version="1">MNMLLIFLTLVCTTLPSLACYGNGCGRYYNFRTCNGPICHYGKYVGYGCRHGVCPFVCYGSGCRTIRTSYNNINPLQLRNSGFYGGWGSGAYGYRGCVGGNCGFWGGCVNGHCGGFYDFRNCRTPSCVSGPYHGYACFDGNCRYICFQGICHTPYAYGLGCYGPGCDGYYQFPKLGYHSICIGSKSFNGDECEGTEDIKKTENNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDF1</accession>
    <name>A0A158RDF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Par3_HAL_N_term domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS521</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000048">
        <property type="protein sequence ID" value="VDM16578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000052001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000052001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000052001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="652"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="848"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1207"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1268"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1402"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1726"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1207"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1281"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1346"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000052001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1749" mass="188858" checksum="C0E0DC4F4CF678CA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDG5</accession>
    <name>A0A158RDG5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS583</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01000060">
        <property type="protein sequence ID" value="VDM16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDG5"/>
    <dbReference type="STRING" id="6205.A0A158RDG5"/>
    <dbReference type="WBParaSite" id="TTAC_0000058201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000058201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000058201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000058201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="848" mass="97953" checksum="7260AA17AED9C68B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDZ6</accession>
    <name>A0A158RDZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IF rod domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6362</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDZ6"/>
    <dbReference type="STRING" id="6205.A0A158RDZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000637701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000637701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000637701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="117"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="5">
        <location>
            <begin position="491"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="380"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000637701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="603" mass="67966" checksum="7FE4CBAFE55CEA7D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE08</accession>
    <name>A0A158RE08_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6413</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE08"/>
    <dbReference type="STRING" id="6205.A0A158RE08"/>
    <dbReference type="WBParaSite" id="TTAC_0000642801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000642801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000642801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255225at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000642801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135553" checksum="994E7257DA02FCB4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE31</accession>
    <name>A0A158RE31_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6540</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE31"/>
    <dbReference type="STRING" id="6205.A0A158RE31"/>
    <dbReference type="WBParaSite" id="TTAC_0000655501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000655501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000655501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000655501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33794" checksum="D25351A2842EB2C1" modified="2016-06-08" version="1">MVIDTPAEPAPNNKGVSKTTGSPSDSKMDDSKDLEFPSSSSSSLQQASGGPQRVGTYIIERTIGKGNFSFVKLARHTVTNVKVAIKIIDKTKLNEENLKKAQREADILKSLHHPNIIKLYQVMESEKLLCIVTEYLPNGELYEYIAKNGYLNEQVARHKFMEILSAVEHCHLNNVVHRDLKAENMLLDQHMSIKLADFGFGTFQPTGPDLLLTTWCGSPPYAAPEIFKGEPYLGVSADIWSLGVILYVLVCGVLPFNAQEVSCLRRQVLEEHVRVPYWLSMCKSPLSLSSSSNCSVELLRFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE70</accession>
    <name>A0A158RE70_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6722</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020318">
        <property type="protein sequence ID" value="VDM30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE70"/>
    <dbReference type="STRING" id="6205.A0A158RE70"/>
    <dbReference type="WBParaSite" id="TTAC_0000673701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000673701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000673701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="139"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000673701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31484" checksum="779BF4788739C864" modified="2016-06-08" version="1">MASQQYYYPQSLNYNPGYFEPNNVHFSQFNYNDASQEKAQNPYFTPAPVDGNISGQFGFEDEPPLLEELGVNFGHILQKDIFYEIELWKVIANRVCCSDWMVASLATSGCVALDRPIGIRKVGSSYLMLFVSFQTLNVLNPMRESPQEVLEDTDLAGPLVFCLIFGGTLLLAGKVHFNYIYGIGLLGCLGMHTLLSLMAPHGVAPTCVVSVLGYCMLPMCVLSTVSIVFSLKSTVGVVLTAFIVFWSALSSSKLFVRALNLEKQRFLVGYPCALVYAIFALLAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB1</accession>
    <name>A0A158REB1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6981</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020336">
        <property type="protein sequence ID" value="VDM31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REB1"/>
    <dbReference type="STRING" id="6205.A0A158REB1"/>
    <dbReference type="WBParaSite" id="TTAC_0000699601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000699601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000699601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="53"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000699601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25420" checksum="8A8E0B70FF670B40" modified="2016-06-08" version="1">MSDLEAVLADVSYLMAMEKSKNVATKAPKKNIIPDSSIRSVMVSYLRRHGKINFEDIFHDRLGFIFFVKFCKAQESPDVHLIEFYEAIKDFELIDSECDRVKEAKRVYDTYIMKELLSKAHPFSSEHVKSVQNKLTEGMKCNSVSRKLFSVYVDDLKRNIKNVFYESFLKSKQFTLYLQWMDVQLNTTLTMSDFSVHRIIGRGGFGEVYGCRKLDSGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ECB1</accession>
    <name>A0A3P7ECB1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000763">
        <property type="protein sequence ID" value="VDM18933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ECB1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="392" mass="44853" checksum="AF73DF46B10DBF80" modified="2019-02-13" version="1">MPFENRYDYYLDASFYQHRIHWFSIFNSFMMVIFLVVLVSMILLRTLRKDYARYNREDNLEDLERELGDEYGWKQVHGDVFRSPTGTLYFASLIGNGVHITVVSLMVALLALIGKMYTERGGVLSTIIFVYALFSPVNGFTGGRTYLHLGGKNWIRQLFVGSLLMPTLVVIIALGINTLALFYQTSRVLPFITMLAVFAIIVFVILPLNLVGTVLGRNIGRSASTGMANPCRVNSVPRPIPSSKWFTKPLIISFIGGVLPFGSIFIEMYFIFTSFWAYKVYYVYGFTLLVVFILIVVTGCSTVVCTYFLLNAEDYRWQWISFFSGASTAVYVYIYSIYYFLFKTKMFGLFQTAFYFSYMAFFCFSLGCMCGAIGYLSANRFVRTIYSTVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EDU8</accession>
    <name>A0A3P7EDU8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001461">
        <property type="protein sequence ID" value="VDM21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EDU8"/>
    <dbReference type="OrthoDB" id="10056271at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="295" mass="32743" checksum="95256520116182ED" modified="2019-02-13" version="1">MCVIPPKETGGLPLTHYELRIQPSPNERFHGPFAYLPGRRVVRLPDLTPNHFYKFALSAVTSAGRGPNTYIQVMTRKIGVPKLKLIATDSDVTSSDYLVRWILESDGGSPVIMYKIKIRPVETSWGPVLAGILGLLFWFTYDQSDSRPPAKSATVVNSNRRQECIWASAIGDYGLIKKLKWTILQSQITPLGSWTVFDVLSRDADRRTRHGVEGMYRIKSLQPGTSYEVNLVGQNSVGQSNPYVVVLQTSELIGTSGRLLGEPISQYFHGDSGTRVAHTLFLLAALLMGQQDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EJT9</accession>
    <name>A0A3P7EJT9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000057">
        <property type="protein sequence ID" value="VDM16667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EJT9"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47478" checksum="3C1728BC3C05FFE7" modified="2019-02-13" version="1">MVLGDVTRSPRIKNHANSFAREGWRVKFAGYRGLQPTADNDLTCYYLSQVPIFVDDYLPRFISLFFKIIFLSISLFVYLVLHMREDLLFVQSPPAVPTLLIVYFFALLKRMYKLMELTFASWFLNSNTFVKTRHFAVSKALQKNLREQTGIDAIVVYDRPTKDFKPTTVEDAHRLFCRLSYDYPQLRGPEGSTQSTAFTEVVDPSSGTCGWRVDRPALLISSCSWTPDDDFAIMLEALDSYNATVTSSPNISFHKLIYIVTGRGPLKSHFQAIIKERKWEHVEVLTPWLEWSDYLLLLGAADLGVSLHHSTSNLDLPMKIVDLIGAEVPVLALAYPALSELLPNGQLGYHFSTSAALTDHLTRLLMPKEDFEGVGDAPDLIRCRRNLHELKQFPNMDWHTHWLSTVLPVCEKLLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ESA6</accession>
    <name>A0A3P7ESA6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003624">
        <property type="protein sequence ID" value="VDM24133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ESA6"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="108" mass="12969" checksum="FC35641CE4918FF8" modified="2019-02-13" version="1">MSNELFPISLQLERRRDANGRVYYVNHRTKTTQWEDPRQTTAPLPPGWEMRYTPEGFVFYVDHNTRTTTFKDPRQPGSVYVVLKLHLFDFLRLNGLFLDNESSMWKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EV68</accession>
    <name>A0A3P7EV68_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007984">
        <property type="protein sequence ID" value="VDM27220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EV68"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="2">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="210" mass="24782" checksum="7CB6F417A078DB80" modified="2019-02-13" version="1">MEAHSNGFRFTSIRGDKVDILYNNIKHAFYQPCDGEMIILLHFNLKNAIMYGKKKQDNIQFYTEVGELTTDLGKSHGRMYDRDDLEAEQREREMREQIKTAFKTFVERVENLARRYNLEFEVPFRDLGFYGCPLRTTVFMMPTSSCLVSLSEWPPFVITLEEVELVMFERVSLSIKTFDMIFVFKDYRIKPAMITSIPSNSLDHVKEWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FBY9</accession>
    <name>A0A3P7FBY9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020578">
        <property type="protein sequence ID" value="VDM33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FBY9"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045661">
        <property type="term" value="P:regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018275503" description="Band 7 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="68"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="211"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="422" mass="46039" checksum="FCAABEF493BEDDF3" modified="2019-02-13" version="1">MGGRRVRTIIGGWGWAWCCLSNVQTISLEVMTLNPTCKHVETIEGVPLTVTGVAQVKVLSDEQILTLACEQFLDLDPYRVENTILQTLEGHLRAILGTLTVEAIYKDRDQFASLVREVAAPDVGRMGIEILSFTIKDVFDDVDYLNSLGRPQIAKIKRDANVGVAEAERDAGIVEAECEKARMEVRCKMDAAIAEHQREFELQKAGFDVEINQARAEADLAEEIQSAKERQLIRDEELKVEIVEKTKRIEIEEQEVKRVAKVLEATVHEPAMADVFRINQTVEAEKHKKMLLSLASAERVRSIGLAQAEVTQAKGAAEAEGLEARSTAFASFTEAAKLRLMLDALPALAAEVCAPLAKAAEIVLIGESSRPEGAQSTPVATLSDIGRDFVRMSATVPPSVRAITGVDLTKIIGQIPGASVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FI79</accession>
    <name>A0A3P7FI79_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020608">
        <property type="protein sequence ID" value="VDM33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FI79"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="328" mass="36935" checksum="788EE5C7A8FAF334" modified="2019-02-13" version="1">MYWVVSISLVFINKWLLSNPDLDAPLFITWSQCLVTVVLCIILSKISSAIPEKLSFPNIDFKWRTIMPLSCVFFTMVVFNNLCLKYLDVAFYFAARSLTTVFNVVLTYLILRRKTCYKAIACCGVIIAGYITSVLQENELGTLSLSGLFYGLSASFSVSLFSILTSKNLPHVGGSVWRLTFYNNLNTSVLFIVVLRGKIFKKFPLSYVGLFFWSMMLISGIFGFAISYTTTWQIQVTSPLTHNISGTAKAAVQTIIATVISLHFKSVLWWVGNGMVVVGSMAYAYVRHKLALKEQEEQRKYQPVSNDDREIPSLSRVVAEKDDSSRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FRC3</accession>
    <name>A0A3P7FRC3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020366">
        <property type="protein sequence ID" value="VDM31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FRC3"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="132" mass="15174" checksum="0E6F60348C454BF4" modified="2019-02-13" version="1">MHKRVLFPSYSVASTTSISHDEFRFCRICHESDGSTADLDFDAYGKLIAPCLCDGTLKYVHEKCVQRWMEVSRSKSCELCRFEYEVLTFTKGEVGRNKATLNLGSYLYSNQTVHLSIHQHLCFLFRKSSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FWJ6</accession>
    <name>A0A3P7FWJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025022">
        <property type="protein sequence ID" value="VDM37016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FWJ6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="41" mass="4056" checksum="377FEF34D79CE21F" modified="2019-02-13" version="1">MAWRSDEGPATGWGVSETGIAPIDKSDTVAAVASVVGCCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GB92</accession>
    <name>A0A3P7GB92_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01026087">
        <property type="protein sequence ID" value="VDM37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GB92"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="55" mass="5570" checksum="CD29B75D967B0DCC" modified="2019-02-13" version="1" fragment="single">MRLCMNVTTVLCCRMTPLQKAAVVRLVSHGLDGVGGGGRPVTAAVGDGGNDVAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GR79</accession>
    <name>A0A3P7GR79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004704">
        <property type="protein sequence ID" value="VDM25138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GR79"/>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="207" mass="22501" checksum="36FA6FF5C68255EB" modified="2019-02-13" version="1">MRVALTPHSLPIGASHRLWISAEGSPIPRTALNGDNHEADGTPTKTTEEVPGTKRARRHLSPVPRSDSRGSGLGRGGGGEQETGNATDTMEKNQDPRLLDTFCVASFTLPAWRDKDTAAGDGAQLDEHENLVRDIAAINPDVFCVKQAHADYATLHLRPELSRQGYQCSGGTDDTAASFQSFIFFSREVFSEVAFHCRPVQSMARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HG25</accession>
    <name>A0A3P7HG25_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020552">
        <property type="protein sequence ID" value="VDM33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HG25"/>
    <dbReference type="OrthoDB" id="6237626at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="691" mass="76797" checksum="FC41A5B4760F251A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHQ3</accession>
    <name>A0A0R3WHQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor-like protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS86</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000006">
        <property type="protein sequence ID" value="VDM15811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHQ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WHQ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000008501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000008501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000008501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM15811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000008501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23822" checksum="6C011B0B30B7A4D3" modified="2016-01-20" version="1">MGVLLSRIWSFFRPEGTKIVLVGLDNAGKSTILYQFVLNEAVQTSPTIGSNVEEFKWGNLHLVMWDLGGQESLRPTWSTYYAGSEFVILVIDSTDRDRLPLSMSELHAILTSEDLRKAKILIFANKQDVVGCMSVAEVGHKLNLTSIKDHTWHIQACCALTGEGYVDENFFQWYLLAWRRSDSSASGLFPLPNKSKHCALSLTLILMLYSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHS9</accession>
    <name>A0A0R3WHS9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apoptosis inhibitor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS117</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the API5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000008">
        <property type="protein sequence ID" value="VDM15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHS9"/>
    <dbReference type="STRING" id="6205.A0A0R3WHS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000011601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000011601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000011601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000011601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58605" checksum="64A37E83C411B02B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHX0</accession>
    <name>A0A0R3WHX0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS160</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHX0"/>
    <dbReference type="STRING" id="6205.A0A0R3WHX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000015901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000015901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000015901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM15996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000015901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="701" mass="81005" checksum="37542D439C723DA6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHY0</accession>
    <name>A0A0R3WHY0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS173</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000011">
        <property type="protein sequence ID" value="VDM16019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHY0"/>
    <dbReference type="STRING" id="6205.A0A0R3WHY0"/>
    <dbReference type="WBParaSite" id="TTAC_0000017201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000017201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000017201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="14">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="164"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM16019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000017201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49773" checksum="ED122810570B7941" modified="2016-01-20" version="1">MANDASAALNKGIDTIVKATEEDKKKNYEEALRLYQIGCDYMLHALKYGCHNDKSRDSIKTKVCQYLDRAEKIKNYLESNPAEEVRAISILSYCSTERKPVKADKEEDAEKTKFHNQLSEAIVMEKPNVRWDDVAGLEAAKEALKEAVILPIKFPHLFTGKRTPWQGILLYGPPGTGKSYLAKAVATEANKSTFFSISSSDLVSKWLGESEKLVKNLFELARQHRPSIVFIDEVDSLCGSRSENESESARRIKTEFLVQMQGVGTNNKDVLVLGATNIPWCLDSAIRRRFEKRIYIPLPEAPARAKMFRMHLGTTPHDLKDADFKKLADMTDGYSGADIAICVREALMAPIRKVQTATHFKKVRGPSPTDRCVEVEDLWTPCSPGDRGAVEMDWTQIKGDKLFDPIVCMDDMIQAVKRSKPTVNEADLQKQRDFTRDFGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI33</accession>
    <name>A0A0R3WI33_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS232</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI33"/>
    <dbReference type="STRING" id="6205.A0A0R3WI33"/>
    <dbReference type="WBParaSite" id="TTAC_0000023101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    <sequence length="1257" mass="140308" checksum="B86F24BAC439C2C4" modified="2016-01-20" version="1"> </sequence>
</entry>
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        <source>
            <dbReference type="EMBL" id="VDM16796.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="VDM17145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000089501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="594" mass="65836" checksum="5CE669167B297CD1" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJQ2</accession>
    <name>A0A0R3WJQ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LRC72 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS916</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000129">
        <property type="protein sequence ID" value="VDM17173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJQ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WJQ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000091501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000091501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000091501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042655">
        <property type="entry name" value="LRC72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000091501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34526" checksum="010D3190573F547F" modified="2016-01-20" version="1">MSLVSEEDVDAENVQAARQMLAERIWAWCSERHAGQTQAPGGPPLRCLTQLDLATSGLRALPPPQVLGALPCLRILNLGRNKLKCLCGGLLQCSGLEELYLDDNYLTSIRGELKNLHCLRVLSASRNSIFSAEVGALSILQISDSIGALMLIRFSPVLKETVNELKQMHRIEVVDLRQNHLCCDSTYALLMWRTLPNLSLLDGRGKFQDSASFAAIKRTRKQAKGGPRRQAKEMSGNAHVIFMQWADTKAFFVYHRKKKQSSEATVCERFHRSQLRKVYLSKSTQTAVQENTECLMRNSVTLETHSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKU2</accession>
    <name>A0A0R3WKU2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endonuclease III homolog</fullName>
            <ecNumber evidence="13">3.2.2.-</ecNumber>
            <ecNumber evidence="13">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="13">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NTH1</name>
        <name evidence="15" type="ORF">TTAC_LOCUS1343</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="13"/>
    <dbReference type="EC" id="4.2.99.18" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01000270">
        <property type="protein sequence ID" value="VDM17842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKU2"/>
    <dbReference type="STRING" id="6205.A0A0R3WKU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000135601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000135601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000135601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="76"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM17842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000135601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33485" checksum="BA3EB584FCCAFBED" modified="2016-01-20" version="1">MKRSRRRGNPSSSEDIEDVVPDLHWQPSDWFTVFENILLMREKANAPVDSMGCHALADKNADPKTSRLQILLGLMLSSQTKDEVTAAAMARLCDRGVANLTALQNISEADLAGILQPVSFYKTKAKHIKRVAQILTNDYNGDIPNTIEGLLALPGVGPKMAHLAMKCAWHQITGIGVDTHVHRIVNRLKWVPEPTKSPEETRVALESWLPMDLWGEVNQLLVGFGQQICLPARPKCSCCLNAPICPAAAKFTSTGRKRRTKQTDPSFEGTDVQEAVVVVEQVESETEVQIMDECLKRKAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKZ3</accession>
    <name>A0A0R3WKZ3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1407</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000300">
        <property type="protein sequence ID" value="VDM17947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKZ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WKZ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000142001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000142001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000142001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000142001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25522" checksum="F58C26EFE4A6F059" modified="2016-01-20" version="1">MSLSESQTKKVIESQLCRAAQVIEDVVDQEIAKLDNMDEDDLEKIRQRRLAELKEKANKKEEWLANGHGIYSELASEKDFFTICKQSANVCAHFYRSTTVRCAIFDKHLSALAPRHLECRFIKVDVEKSPFLVSRLGVRVLPTLVLIKEEKVVGRVIGFDDLGGHDNFSTEMLAWRLGVAGVVDYNGDLSQPPDFAKCKRKVMPFRRSTRTIRDGGSDESDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL79</accession>
    <name>A0A0R3WL79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNase_PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1502</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000347">
        <property type="protein sequence ID" value="VDM18112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL79"/>
    <dbReference type="STRING" id="6205.A0A0R3WL79"/>
    <dbReference type="WBParaSite" id="TTAC_0000151501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000151501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000151501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000151501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28752" checksum="DF79463F6F15E3F4" modified="2016-01-20" version="1">MSELYFNDRRVDGRKTSELRAIQCEFLPGLADGSVLLQQGNTKVTASVFGPHPCNAKLDEVPDEVYVTCQYNRPPFVNTSGDRQKHTHSDKVAAEYAMTVEEVFSALIRGSLYPTAQIDIFIEVLQSDGSEFSTAINAASLALVAAGIEMIGFAVASNVGFYGSRLFADLCRYEENSRVTRVTVVCLFGDTDPGSNTLMENLPPPSSQQLFGARLLHTRLSSWLPSEKLIVLIRGGVEVAKVIHGELAENLRRYVKLSERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLC1</accession>
    <name>A0A0R3WLC1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1546</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000370">
        <property type="protein sequence ID" value="VDM18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000155901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000155901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000155901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000155901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="909" mass="100729" checksum="FEC521C81B3AF53D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH8</accession>
    <name>A0A0R3WLH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1603</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000398">
        <property type="protein sequence ID" value="VDM18274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH8"/>
    <dbReference type="STRING" id="6205.A0A0R3WLH8"/>
    <dbReference type="WBParaSite" id="TTAC_0000161601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="3">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29567" checksum="C0B5D11C2F52C7EE" modified="2016-01-20" version="1">MGHLYWQLNDVWAAPTWSTIDASGQWKIAHYLAIRGTASITHPIGRAIVSRVRNRVLINWAPPINPLEDDQIRLSVVCSPVLSFTLHPKVLFQSTDNLGPWRPNGCPLQVTNFTVEWLLSKCSSGVLTTILENAMIQTKDTMVLLTPKEMAHLWPVAAGSIKVTSVRRVNASSPEVQNPPFRWNQAFKVHLRAKSPELFVWLVIDPYLNLDGWFSSNAFNMLTCGKRVLFYFVQGRTAVSEKQLQKAIRVYTLASIASDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK1</accession>
    <name>A0A0R3WLK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tt4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1626</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000414">
        <property type="protein sequence ID" value="VDM18307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLK1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLK1"/>
    <dbReference type="WBParaSite" id="TTAC_0000163901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000163901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000163901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000163901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27372" checksum="F408992CE2495530" modified="2016-01-20" version="1">MMSRTGTSRYFDPNVLFRFRDIEKPVQIHLKNVYSLLSVGLIAASIGSFVFATSSFIQYWGFGTLLLSAVVSIASCCYIMFTEHTESRLWSRMVAFLVFTLSTGVGLGPLVNFALQVNPSSLPAALLGTAIIFVAFTFASLLTRKRAFIYLGGILGMAIGVISTFGLMNLFLRSPALFQVELYLSFLIFCGFVVYDTQLIVFKRQLGDTDFIRHALDLFVDVVELFRHLLIILNSKRVSFPLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLQ7</accession>
    <name>A0A0R3WLQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF389 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000444">
        <property type="protein sequence ID" value="VDM18390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000169501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000169501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000169501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543859at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000169501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38450" checksum="CA08D98E890250EB" modified="2016-01-20" version="1">MDGAKLTNGGSAIELRHSDVYHAISNQGNFNFNYLCFLICAAIVADIALVTDSAACVFASMLLSPLMEPIMCIIFGLSLREPRMTTKGFRNTSVSLIICIIVGIAFGIPAHFISMFQGIAPYPTSEMSSRGEAKALIASIVVASASGVSVSFAILSNSLAAMIGNAISLSLLPPSVNCGQFFLLAVIALIDRPYVMKKTDTLKENNTISVTVVQCQYRWIKDYNFIYITNACDAPTEFAIRGVVSFCLTLLNIILIIITGYSVNRLKDLVPQSFTNDETRRFYTKDLKEVRDNYDCVHRLKAADLAAQAYQEYLRLSLHPTEGDYTAEDTEQLTANFQAVMEFPFRGASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLT7</accession>
    <name>A0A0R3WLT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1712</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000463">
        <property type="protein sequence ID" value="VDM18430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLT7"/>
    <dbReference type="STRING" id="6205.A0A0R3WLT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000172501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000172501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000172501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6412627at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF72">
        <property type="entry name" value="BAT5L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000172501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47598" checksum="FE3216E31B743057" modified="2016-01-20" version="1">MKCVRDALTLYGFRYPWPAQFDVRDLEPRLRFERKAVVNRYEASYSVLTPLLSFLANTIGVRMVYPGCMGMFNSWALEPRMKALEALRSKCNARRVGLITAEGLFVEAFYVDRRRSESENGKTMVICCEGNAGFAEIGISGVPLSNGFSIFAWNHPGFGSSMGMPFPEQEMNAVEAVVLFTIHYLHFEPADIRLFGWSIGGFTATWAAMHLPSIGGLILDATFDTLEELSRNALPFIGESIPVALVRKFFNLKNIAQIIEFPHLFNDDTEVLLWKYLAMDKAEQESYLMKHGIVDEVMVPILQHEFRKEMLEFACADDDVSGLVMDVHRSLLFPSHLGESGISDAMKRSVLIYLTSKYFVEAKGSHCTTLDQASFQEPWSESLVLYRSQTVNVDLEAECSSTNDGFDDDADEKDVNDWEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM72</accession>
    <name>A0A0R3WM72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS_1_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000551">
        <property type="protein sequence ID" value="VDM18587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM72"/>
    <dbReference type="STRING" id="6205.A0A0R3WM72"/>
    <dbReference type="WBParaSite" id="TTAC_0000186001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000186001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000186001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000186001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19725" checksum="5E49E217CB501CD1" modified="2016-01-20" version="1">MAPYLATFFVVCLLVNILNAPYKIQITEFVSIAMMISLYGLPLMVVIIGTVILLAGIGRTLRGFKILPQIFGLLTLGFISSAMDYVPWIDFGRHLQASSLAYAGFYAQVVRAILLCCEYAREEKPVGWKRLFSECIGFPAVTAVFMPASFVLFTDWLQWRNGQHEVDCQTCAHWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM94</accession>
    <name>A0A0R3WM94_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1869</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000568">
        <property type="protein sequence ID" value="VDM18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM94"/>
    <dbReference type="STRING" id="6205.A0A0R3WM94"/>
    <dbReference type="WBParaSite" id="TTAC_0000188201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000188201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000188201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000188201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32437" checksum="BE7345CFB317A49E" modified="2016-01-20" version="1">MSSIAIARIIEFPEVPRLRRCQMPAYMSLLGSSDRPHPPIANFSNLPKAFGVCVYAFMCHHSLPGVITPIDKKQRLFSSIILPVYLLIYFCYLLLSGTAITAFDYIHDLYTLNFVPSDDPNLRPGWFLLLLEYFLALYPAFALSSNFPILGTTLANNLIAIFLEFLPPGRNIVLVIRWCVPFLALIPPILIALFVNDVGQLVSITGAFGGLFLMYVFPVVLVFYARRALEAKFKSEPSREEPVAIDQERHCAVNRYQSPFLHPIWLVVVALWAASCLLILILNKLGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN31</accession>
    <name>A0A0R3WN31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3453 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2156</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000806">
        <property type="protein sequence ID" value="VDM19062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN31"/>
    <dbReference type="STRING" id="6205.A0A0R3WN31"/>
    <dbReference type="WBParaSite" id="TTAC_0000216901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000216901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000216901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000216901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="625" mass="67024" checksum="611B1A2A427739ED" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN79</accession>
    <name>A0A0R3WN79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 18 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2204</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000849">
        <property type="protein sequence ID" value="VDM19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN79"/>
    <dbReference type="STRING" id="6205.A0A0R3WN79"/>
    <dbReference type="WBParaSite" id="TTAC_0000221701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000221701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000221701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="897"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000221701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="969" mass="108575" checksum="7D33429E1825F718" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN86</accession>
    <name>A0A0R3WN86_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2211</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000855">
        <property type="protein sequence ID" value="VDM19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN86"/>
    <dbReference type="STRING" id="6205.A0A0R3WN86"/>
    <dbReference type="WBParaSite" id="TTAC_0000222401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000222401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000222401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000222401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9055" checksum="DD4E1B672576B366" modified="2016-01-20" version="1">MPKVKGEVVCLLSDDQVLDLAKSPDWPRIFTYLPEGRTGKSKSDEAYLDADALPPSDPEDSEDYEDKCGSSEESDEACKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP54</accession>
    <name>A0A0R3WP54_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001175">
        <property type="protein sequence ID" value="VDM20355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP54"/>
    <dbReference type="STRING" id="6205.A0A0R3WP54"/>
    <dbReference type="WBParaSite" id="TTAC_0000254201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000254201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000254201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10518585at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000254201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14731" checksum="8A928D216F734A1C" modified="2016-01-20" version="1">MEVTARRLMSSKRKTLGLGIIVIIVYAIYVYVFYFSSTATSSPADTPPTVEESKIRANGSSKRLRFEELAGIPDAEWLHNFDPSVYLFFPQSTPVRETLQSLIDGKPFPQVRPSLPTSYLNPCFDNQAGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPB4</accession>
    <name>A0A0R3WPB4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2590</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001252">
        <property type="protein sequence ID" value="VDM20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPB4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000260401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000260401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000260401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="256"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000260401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="602" mass="67955" checksum="B8F4D4C2D473C3F3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQH3</accession>
    <name>A0A0R3WQH3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2998</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001788">
        <property type="protein sequence ID" value="VDM21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQH3"/>
    <dbReference type="STRING" id="6205.A0A0R3WQH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000301301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000301301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000301301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000301301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18129" checksum="FD94746F8EEB3AA3" modified="2016-01-20" version="1">MADIIQVDIYEYLGISFESSAKEIKRAYKNKAKELHPDKNKSDPQAKEKFQKLKEYYDILQDPKLKIAAAERHAQLDGERRRLKEALEAKEREAAARRKEVDIMVQNEKTAQRIRKEWEDYKEATVYANRDARFEIKKSTRFGGHVVVSVRPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQH8</accession>
    <name>A0A0R3WQH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001792">
        <property type="protein sequence ID" value="VDM21724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQH8"/>
    <dbReference type="WBParaSite" id="TTAC_0000301801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000301801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000301801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288609at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM21724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000301801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119974" checksum="C1BE7BB6F5DD0631" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR62</accession>
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        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
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        <name evidence="4" type="ORF">TTAC_LOCUS3237</name>
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    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002106">
        <property type="protein sequence ID" value="VDM22214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000325201-mRNA-1">
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        <property type="gene ID" value="TTAC_0000325201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241135at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133059" evidence="2">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
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        <location>
            <begin position="398"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000325201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="646" mass="74085" checksum="E45F2F179BFEB2CA" modified="2016-01-20" version="1"> </sequence>
</entry>
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    <accession>A0A0R3WRE6</accession>
    <name>A0A0R3WRE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">TTAC_LOCUS3321</name>
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    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3WRE6"/>
    <dbReference type="WBParaSite" id="TTAC_0000333601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000333601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000333601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000333601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13726" checksum="660852B9DEC2D761" modified="2016-01-20" version="1">MGNGMLTHKKPSCLIQDGGEEGQRLSHSLRSLLLTNRMSTACAGLFHVVCLLRLLSTILNVPLRYPMEEASSNPNDAFRPRILDPFVGDQFEGRLVRLTTLLALCIQRNHEGAFLQKIIVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSQ0</accession>
    <name>A0A0R3WSQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neural proliferation differentiation and control protein 1</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS3775</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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    <reference evidence="2 3" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000379001"/>
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    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000379001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10625" checksum="6E49D5FF1D4D6EAA" modified="2016-01-20" version="1">MTWESSSTLHLHRAAFGERVGSTDGDKEPGSVGDLSHAADRSLAHSAQMYHYQQQKQQMLAMEQATGKSRISDSNSGSEGEGEEPDVNVYECPGLATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT07</accession>
    <name>A0A0R3WT07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3882</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Cyclophyllidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003224">
        <property type="protein sequence ID" value="VDM23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT07"/>
    <dbReference type="STRING" id="6205.A0A0R3WT07"/>
    <dbReference type="WBParaSite" id="TTAC_0000389701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000389701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000389701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259429at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000389701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8459" checksum="009621FD86B4EB21" modified="2016-01-20" version="1">MGFQPAPFCSPRGTATATLIAEVTPTAATQSSHAQLVAASATTGPDGIIRLSCLPPKQAHTLGRCNFLSQKKLVSPAGALIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT36</accession>
    <name>A0A0R3WT36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhoLip_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3911</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003278">
        <property type="protein sequence ID" value="VDM23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT36"/>
    <dbReference type="STRING" id="6205.A0A0R3WT36"/>
    <dbReference type="WBParaSite" id="TTAC_0000392601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000392601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000392601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000392601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21817" checksum="9DC25484572C4C58" modified="2016-01-20" version="1">MQIIFSAIFYIISVALFPGFLMVGYATIFTMFPVFSLVLDKDVADSVAMTYPELYKDLTKGRELTVKTFFIWIVISIYQGGVIMYGALLLFDSDFIHVVSITFTSVLLTELLMVALTIRTWHFVMILAELASLAIYVIALVVFKSYFDQAFLLTWNFAWKVFAITAVSCIPLVILKCIRMKLRPPIYSKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT64</accession>
    <name>A0A0R3WT64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ_6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3939</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003327">
        <property type="protein sequence ID" value="VDM23809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT64"/>
    <dbReference type="WBParaSite" id="TTAC_0000395401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000395401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000395401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000395401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47164" checksum="AADCEC051EB00793" modified="2016-01-20" version="1">MRINKSLSHVVRNIRPHNRKALLRHGQQPLPNTPSNQYFSSVVPGGPADRAGIREGDYIIEDPIEADPMGCYVLTAPGLSVKSRQSHRRDTGVEGPKSACRHYILNAAGTCIGGPANSYQNAPRFPIPRCALQIDGQDVKNACHEDAVECIKNCGDSLIIRVMSVYKTSGQRQLNGRSELYQTPRTYRRRRQSDIVCESSSSSSTSSNSINSDSEIVVRASEPSIRKKLPISQYSEKKWREPLGADARSRSRDRRIRHPSVRAQSYSVGKDSIRLNAISPAARSQERVYVFEKIDGKANSSSTLGELQRTEGCLTEKERCEIRRAFRYLQTMPEGPVRPATPFILGNQSESQSTAQRKQSRSPSSGTESEHLNHVHSVVASDCLDSGGEAASTVRPGNKDITSKTSSSSGHAMQPFHSSFSVGCLQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTG7</accession>
    <name>A0A0R3WTG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLEC16A_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4042</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003543">
        <property type="protein sequence ID" value="VDM24047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTG7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000405701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000405701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000405701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="1">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000405701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45428" checksum="5E7A61DEF249BA2D" modified="2016-01-20" version="1">MRNVFVEPTESDFVDIFDHEVCRFRSQKLSPSKLLENTAFLLSHVDDALKLFSNRSEENLTELRNANVPAASHVTGLQPRGALDGPPYSALPFSQLEHIQRIIAVYLCLHAYLCEYVLAGETIGEPLNEVTSPALERISAFASFGDIPPTGKVLVSNSCSFDISEYQLFGCKVEHQSGQHEKQYFLLTELQIVSVVPSHRKIGLGIVVFCGLIQDTELRCDPTDDCALIIVAYKPGDRSRLTVRRTMMEAGPAFSSSPSSSSSSPLPNVFPIINAKLRFCTSFQCSAFYKMATYRQEKIVASKQEKLKQMLSVSDKPIRPSVQAILSEGAPNQPRLHAPLTIAKPLRSTSSAPTTLLQKARAYSLSSAPSVNNHAPHDIPNSTASKTTGEMQAIAMVDLMRRHNTFRTTSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTJ3</accession>
    <name>A0A0R3WTJ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4068</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003595">
        <property type="protein sequence ID" value="VDM24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000408301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000408301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000408301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="115"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000408301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38558" checksum="C2DB98B220CE36F4" modified="2016-01-20" version="1">MVLETVGNLLTFSVSVAFVATRETLAAGFAGLVISYTLNVTQGLSWFVRMATELETNVVSVERIREYSELTIEWFTYSTLNIIFKKVTWSDMNSPSAPWDVPTKQPPPQWPQGEIEFVNYSTRYRDDLDFVLRSLSFTISPGEKIGIVGRTGSGKSSLVLALFRIIEGREGEIRVDGRNIAEIGLHDLRGRITLIPQASRSFHCSCFYLLDPVLFSGTLRFNLDPFNTHSEDEVWEALTLANLRPFVEEASCDGLKMTIAEGGNNLSVGQRQLVCLARALLRQSRILVLDEATAAVDPQTDQLIQRTVRKEFASSTVLTIAHRLDTIIDYDRIMVLDAGRLIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU89</accession>
    <name>A0A0R3WU89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4314</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004134">
        <property type="protein sequence ID" value="VDM24662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU89"/>
    <dbReference type="WBParaSite" id="TTAC_0000432901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000432901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000432901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000432901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17530" checksum="C60F781234E92F08" modified="2016-01-20" version="1">MAIMEKWTNRLTSVICWLNKRVGSQSLMLEATFSASGSIRMHLLRIDAGWRPASLLRHEAEARHYGRSTRISRRRWRSVLRLGVSTCRTEEKSDRPPCLSTTQTVTSAMDPDAPSPPLTEIASYVCDTCGSAFKNDILLRAHLVHEHQSRRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUJ6</accession>
    <name>A0A0R3WUJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4421</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004373">
        <property type="protein sequence ID" value="VDM24900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUJ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WUJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000443601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000443601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000443601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kindlin-2 N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FERM central" evidence="2">
        <location>
            <begin position="384"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000443601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48326" checksum="8F6B5A369E23ECCA" modified="2016-01-20" version="1">MISDGGHYVDGSWLLSIRIDSLNVDRQMRVKGDWSIGRVLVGLIEGLAHPQKLACEASDISLTPGLINSGWSGFALWWPLKNRWILQTHASLDQYGLQADARLHFIRVHGRLRVQLPDLQTRVFCDVNFTEPVFRVVILICKHLGIAHPEELSLQYTDFDRFCSPNQGRAPSIWNEQWSTLPASARKSFKKLAFTSPSKTDLRQKRPASCVLPSIDQTDKPTRNVIPNSQTMSRRPQVYGPPRVRNRPVSGNSPLSPTRPDSIYVSQSLYGAPLSKLEICDDSSLVSSPQMTLSEALISGGIQRHRGFFARARFSNAWLELGRSLMEQGIRPSALNLDDTLDSPTIDPETEGKENGVNGVETDKIPLLRLRFKYNAFYDLTRKNNSVRINQLFEQARWSVVSEAIECTNEEAALFAALQLQVRTQLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUP1</accession>
    <name>A0A0R3WUP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4467</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004517">
        <property type="protein sequence ID" value="VDM25015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUP1"/>
    <dbReference type="STRING" id="6205.A0A0R3WUP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000448101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000448101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000448101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003330at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133008" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000448101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="18694" checksum="015AF357A964B221" modified="2016-01-20" version="1">MSALNLAICLAPSLFHFSSLLVPTTPVSPLLANFGSRRRKKLDPLGGLEPKDLAEQAAAQKCLCALITYAPSVFLVTESIVLKTRLDSERIETPRLSSVLSATNGDANIWLQRQVEILLRDCGSSIAPTSSGTALTTTSAISTAGIGAGSVGTAAKSVTGKQTWSSLSREVLKAYSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV71</accession>
    <name>A0A0R3WV71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">4F5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4648</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004956">
        <property type="protein sequence ID" value="VDM25359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV71"/>
    <dbReference type="STRING" id="6205.A0A0R3WV71"/>
    <dbReference type="WBParaSite" id="TTAC_0000466101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000466101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000466101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM25359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000466101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8330" checksum="B43053D52B9718EE" modified="2016-01-20" version="1">MARGLQKIQSQKRNQERQNAKRNPSDNKKAADAKLTFSCCVCKTQMPDPKTYKMHFESKHPKAELPAELREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVG4</accession>
    <name>A0A0R3WVG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4739</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005208">
        <property type="protein sequence ID" value="VDM25557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVG4"/>
    <dbReference type="STRING" id="6205.A0A0R3WVG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000475401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000475401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000475401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000475401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19317" checksum="58D4FA90D5A862F7" modified="2016-01-20" version="1">MECFRWFQWFEEGDKGIITIEDVCATLDIPLPLEYRRKAEQNNVRSEGLIQETVETPALFAAPPMPSSASSLEKSTLDGVEVLPGNAASDDVLETCVRLVKEYSGPHGAEKDLAGYLKEHMEMRYRKHWEVVISISAIGCAVAHEVNMFIHFRYKDHIYLLFLVPDMRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVS9</accession>
    <name>A0A0R3WVS9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4855</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005496">
        <property type="protein sequence ID" value="VDM25770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVS9"/>
    <dbReference type="STRING" id="6205.A0A0R3WVS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000486901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000486901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000486901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000486901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20231" checksum="EC1C758CF69D5844" modified="2016-01-20" version="1">MNDLESLFPYVLLYSVLPRIKALALLSCHASASVAETSRSAQSMAIETVTPPRRRHRDAVSVLRALASCVTPHLGLPAYGCALEPWLGAPGLRQRSNRLAFAAGRNAARHVARRYLANDLTALATEAPRIDCLMPLQTGESIRKELAEGVISQQEAMERLLLLLAPKDTWELYKNAGNTVSLAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVX6</accession>
    <name>A0A0R3WVX6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI alpha-1,4-mannosyltransferase I, catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GPI mannosyltransferase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-glycan biosynthesis class M protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS4901</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005634">
        <property type="protein sequence ID" value="VDM25852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WVX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000491601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000491601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000491601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM25852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000491601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14753" checksum="3E7ADBB283EB8537" modified="2016-01-20" version="1">MKTGSSGAFVKYLLSGAVVLRLGLFVFSLWQDATRWPDGQLRFTDVDYDVFTDAAKAMAMGANIYETRPTYRYSPLIALILCPGYFISSVFRLSAPFYSVAYAFGKVVFLSADIFCALLQRSIILTENAASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWZ9</accession>
    <name>A0A0R3WWZ9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquinol-cytochrome c reductase complex 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS5274</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006826">
        <property type="protein sequence ID" value="VDM26602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWZ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WWZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000528901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000528901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000528901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM26602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000528901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15364" checksum="803E16AD715315BA" modified="2016-01-20" version="1">MATLRSAVAKASESWKIKLSQRPPLTKVIQDFNFNTGYYNQIGLLWHDIMPRNSVVTEAFRRLPREEREAIDFRLARAHLLSANKTILPKEEWTKEEDDAPYLEPYIKLVERELRDKADWDNFVSPRTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYH1</accession>
    <name>A0A0R3WYH1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009100">
        <property type="protein sequence ID" value="VDM27686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYH1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYH1"/>
    <dbReference type="WBParaSite" id="TTAC_0000581101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000581101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000581101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000581101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12622" checksum="8B40C8AC29ED708E" modified="2016-01-20" version="1">MVKLVEVEAGRQRVGAALGHRCTFRGSFYRKFGMPWQSARQCNSKHHKYLHRPLVREISVLIEPREDGPVDMLITYVVGRCLWKPAYDIRLFNSDGSMKVTLSLSLASSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYR5</accession>
    <name>A0A0R3WYR5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHD_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009571">
        <property type="protein sequence ID" value="VDM27897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYR5"/>
    <dbReference type="STRING" id="6205.A0A0R3WYR5"/>
    <dbReference type="WBParaSite" id="TTAC_0000590501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000590501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000590501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000590501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14868" checksum="4D5C5D3139B2432A" modified="2016-01-20" version="1">MDLCNQLAGIQNIAKRLEIDIVPAMVGWAFHKAGWAHPEYDGFVVCREVLPALVDAWRAERMSAAASAAADRTERAMTNWKRLTRNLLLFAAFLTAKAFYSLIIFHTNVSLKASCHIGSLNSYSISFVFGFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZG2</accession>
    <name>A0A0R3WZG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZG2"/>
    <dbReference type="WBParaSite" id="TTAC_0000618101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000618101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000618101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244800at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000618101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15763" checksum="C6F36E17A355D6A0" modified="2016-01-20" version="1">MEMRRLTAALLGIAIGLIIIALAITDWRYGLAFGGANHDKEAMTAVTFLIIIGLICLIIVFILDIVMLCQTAVPSGMLTARFVILYISVALIMIGVLVYTARRGGLWPYFLVVVGMVFAVLVAILAAVYSRCVSSERVVVVRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZL1</accession>
    <name>A0A0R3WZL1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6225</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000624001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000624001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000624001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070569">
        <property type="term" value="F:uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF6">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000624001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116834" checksum="EA2DE4821E6ED7BD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZU1</accession>
    <name>A0A0R3WZU1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translocator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6320</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZU1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000633501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000633501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000633501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000633501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17931" checksum="FFA10A29D6848478" modified="2016-01-20" version="1">MDLLQLVVCVGFPYIGSIVGSSVIAKNLEWYKTLTKPEFTPPAWVFGPIWGIIYGSIGLASFFFLHEAKSDANLVLPLATYFVHLLLNWSWPYVFFGLHKLKSSVGIIIATTICAALSAILFHDISAAAAYMMMPCVFFTVFASYLNIGTTVLNQRRFIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X175</accession>
    <name>A0A0R3X175_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6917</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020332">
        <property type="protein sequence ID" value="VDM31201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X175"/>
    <dbReference type="STRING" id="6205.A0A0R3X175"/>
    <dbReference type="WBParaSite" id="TTAC_0000693201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000693201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000693201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000693201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12576" checksum="2920D5DB1676F190" modified="2016-01-20" version="1">MENDEGDTARTVSSRSPSLDLKKRLLLRGQHFHLFAKTADHTSHILHADNPENGGEAAVTEAPFETSSMRPTISPDLKAQILQRVQSVHPSEEEFYDDIGSGEESNAEEMEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1D9</accession>
    <name>A0A0R3X1D9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6998</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1D9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1D9"/>
    <dbReference type="WBParaSite" id="TTAC_0000701301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275438at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="24367" checksum="C3AA9AF52FFDA900" modified="2016-01-20" version="1">MNVWFPFGQGNDNKTDDSNIQRGVEESPTHGTFESTPRTAQFWGLAGKETYTEQSSPVIATTSTVPLMSAAAAAMAHSFFTGEPIDTTNTPLNSLLTAAAASNRHQETCVRVEGFVPSRRSPASSAASEQSAPSPHRTFYPPADGYQQGYAHSTVPRIDNPNLPPPLPPPLSLSQPPPPPLPPPPLHHTPNYSIGSGTSSTAESNPGVSALGNVGGNMEQIWPWMTVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1H1</accession>
    <name>A0A0R3X1H1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox protein abdominal-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7035</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020340">
        <property type="protein sequence ID" value="VDM31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1H1"/>
    <dbReference type="WBParaSite" id="TTAC_0000705001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000705001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000705001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271608at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000705001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26316" checksum="1261C56AE05AFA68" modified="2016-01-20" version="1">MWNPRYLLRWLKYTASMATPNDSPMYAAALTHRQSSYGEADGGSGSSLFTRCTTATSVSAYGTNGDYYQQLQAHAANTRQLLADGAFNAAYPQGSGSGSNIHSYAGGGGAGSGGQLDLSVSTGSRSFQQQQHQPSNSPYGPDSGMARFSSGGGYEEGDPTPPHSYYNANSRPSAALPPPLGMYEQNYRNCYQNNASMTAAAVAAAAYNYHYQQQQLQQQQQQQETDSSYDRAPYDYGRNRYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1T0</accession>
    <name>A0A0R3X1T0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ku domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7175</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020350">
        <property type="protein sequence ID" value="VDM31512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1T0"/>
    <dbReference type="STRING" id="6205.A0A0R3X1T0"/>
    <dbReference type="WBParaSite" id="TTAC_0000719001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000719001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000719001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="12">
        <location>
            <begin position="254"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000719001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="762" mass="84123" checksum="B6E7CEC3258C3EE3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2C0</accession>
    <name>A0A0R3X2C0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS7414</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020371">
        <property type="protein sequence ID" value="VDM31789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X2C0"/>
    <dbReference type="WBParaSite" id="TTAC_0000742901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000742901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000742901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="240"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1319"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1347"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM31789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000742901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1389" mass="155135" checksum="10550EA447B14966" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2C5</accession>
    <name>A0A0R3X2C5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5737 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7419</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020372">
        <property type="protein sequence ID" value="VDM31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2C5"/>
    <dbReference type="WBParaSite" id="TTAC_0000743401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000743401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000743401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259252at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043798">
        <property type="entry name" value="DUF5737"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19008">
        <property type="entry name" value="DUF5737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5737" evidence="2">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000743401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29554" checksum="54E688CC61F33EEE" modified="2016-01-20" version="1">MSRNRSTARYERDSSPPPPPHLPSRSRAAGRLRPRFEELGLNYGFAQADPEKNVGYCFVYRTLKNKLSKGGMACNIRADENEIRLTELEGPLDKREKVRIFTHDIISYYKFNHKAKFVAICIDAYHRRKTGYWFLCFEREGQLSYFCEYLNFLFGLDVVDAYEGQDGDRVSYVDRRSRSARSFLLSQTNRSYDSDLCHFRGQQEPDSYDSGYTDSSSEVYASSVLSSLPPPPPRKMAHPKYSPQKFAKKRNFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2L0</accession>
    <name>A0A0R3X2L0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS7517</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020379">
        <property type="protein sequence ID" value="VDM31911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2L0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2L0"/>
    <dbReference type="WBParaSite" id="TTAC_0000753201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000753201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000753201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052123">
        <property type="entry name" value="Non-rcpt_Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="116"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="242"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="483"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="639"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM31911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000753201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77947" checksum="D2FE49D818032AF4" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X402</accession>
    <name>A0A0R3X402_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8093</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020446">
        <property type="protein sequence ID" value="VDM32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X402"/>
    <dbReference type="WBParaSite" id="TTAC_0000810801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000810801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000810801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970161at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000810801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25620" checksum="8245FE2E5CAC3C02" modified="2016-01-20" version="1">MFFVSWFLIVTYFYGNMGNLMNVVDPMWRILSSHAGIITSLLTGTTSLLFAGGSAVLNFSFSFVLLSFYTSVEVAVTSVVVTTLKRTIFYGMYTLLTHTLFGLDVIVLPSIIATILGAIPLVGTYWVVLPGAVELWCLRGSYWLALLLLLLHLLPYSFLDTAFYSEIKGAGHPYLTGLSIAGGLYCFGTEGVFIGPVVLCCMLVGVNLFRLLLTEETGIMRMHNYPSSNFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X417</accession>
    <name>A0A0R3X417_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8108</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020449">
        <property type="protein sequence ID" value="VDM32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X417"/>
    <dbReference type="STRING" id="6205.A0A0R3X417"/>
    <dbReference type="WBParaSite" id="TTAC_0000812301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000812301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000812301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000812301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37607" checksum="113A21811D8371E8" modified="2016-01-20" version="1">MSIPNSIDRYNMKELLGTGAFSEVHLAEDKLNPGTFCAIKCIRKHGHPEKSGVNTFDEDDFKSREASLKNEISVLRRSGFNYCAKLFCRLSHPNIVQLFDAFEDEDSYYLIMELVTGGELFDRIVDKGSFTEKDASDLIRQVLLATEYMHSREVVHRDLKPENLLFHSPLPTSKIMISDFGLSRIDGTEESLSTACGTPGYVAPEVLSAQAGRKGYGKEVDCWAIGVITYILLCGYPPFYDESDQELFRQIQKAHYEFDSPYWDEISDSAKSFIRSLLQKDPSQRASCTQALAHPWIAKNAARDVNIYAHVSENIRKNFLVRQRWKVGFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4A9</accession>
    <name>A0A0R3X4A9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020467">
        <property type="protein sequence ID" value="VDM32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4A9"/>
    <dbReference type="WBParaSite" id="TTAC_0000823501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000823501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000823501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000823501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17349" checksum="6588EF2A8E9F7A64" modified="2016-01-20" version="1">MRSSLLSLSFLSIGKGGGHPPPMRFMWLWSRLTDPHIHREYEQCQGDLLPSCLLSPPEEATDHDRVFVEGECLHATVRCQSSDVSCVVVFSEKAVIKLSLMRDNLIPSDPGMASVRSLTRYLIALFCEEKRLVPQKPQNSIHGHCSDFIGDHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4P0</accession>
    <name>A0A0R3X4P0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Caspase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8373</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020493">
        <property type="protein sequence ID" value="VDM32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4P0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4P0"/>
    <dbReference type="WBParaSite" id="TTAC_0000838801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000838801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000838801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10004338at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="129"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="289"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000838801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42245" checksum="375EB516C5FD71D3" modified="2016-01-20" version="1">MNAEHRQRLGRMQVDFVKGLRDIDEITDYLLCHEILSRTQAEKILSSGPVIADQVRTLLSVLVRCGPDAYDTFVSALLETNQSSFVEKMTNLDISPRPVPPISPPSRTDAHVTQQSTQSIAAYPVNSTPRGYILLINISKFEVGSGLSNRIGSSEDVVALKSLFTDLGYCVEILLDPTASTLESSLSTFIKSPCHYGVDAGGLIVMSHGVQDYIYTADGKLFAINDILEGFTNRSFPALAGKPKFILFQACRGEEKDRGYTFNPDNASFIPSPLESVDAGIHRTLWKCLPYMSDYIIAYSTLPGFVSWRSEKAGSWFIQILVDVFRKYANTLHVLDLLTEVNRRLVEESQEREFKQITQQSHTLTRPFYLTGTHSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4W2</accession>
    <name>A0A0R3X4W2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8456</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020509">
        <property type="protein sequence ID" value="VDM33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4W2"/>
    <dbReference type="STRING" id="6205.A0A0R3X4W2"/>
    <dbReference type="WBParaSite" id="TTAC_0000847101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000847101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000847101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928974at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22426">
        <property type="entry name" value="ARGININE_SERINE-RICH COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22426:SF2">
        <property type="entry name" value="ARGININE_SERINE-RICH COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="2">
        <location>
            <begin position="306"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000847101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44440" checksum="03E253D046095A82" modified="2016-01-20" version="1">MADKVDGKLCDYGSSMDESEDEARRMSDAQEATSSGSSPGSSGVRSDGKASSPKMLFNTPRQHCDDSSKRSKHGRTSRRTRRSRSRSHSRSRDRSGRSHRRRDHSRERRRDRDNCSHRRRRSYSREGIRRRRQGRRRRSSSSSSSSDVRRSRHSPRHGRDRETAFSRKIIGSRSELAKVQEAVRPVDPIAAKLEAVNKASAIMASAVKPTSVFRLHPTCIGFTGESTPQEVLARIQATQMTQVRAKAEAAAAAANLPSFYNPMSVNAAKLAEQQQKRKLLWSRKSDPVAEAKEEAKSTMWKKTSMVAGKGDSAAAAKFRKLMGIHEDSSNNAAGAPSDEALNQAREQADLFRNLEHEFETSRTLTHTQRGVGLGYSSAMTDYRAYAAMKQAGGSAQQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5M3</accession>
    <name>A0A0R3X5M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NT5C2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8763</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020581">
        <property type="protein sequence ID" value="VDM33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5M3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5M3"/>
    <dbReference type="WBParaSite" id="TTAC_0000877801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000877801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000877801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000877801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14032" checksum="B75B8F668D210F90" modified="2016-01-20" version="1">MHDFLVDGHEFWVKRQHVSTNVYLYPLQMSRSSATFTHLIGAQGKDVLYTGDHIFGDILKSKRQVGWKTFLVVPELLNEIYVWKKKNSLFERLNELDNELADKYKYSHHLFTSFLNALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5W3</accession>
    <name>A0A0R3X5W3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8864</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020612">
        <property type="protein sequence ID" value="VDM33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5W3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5W3"/>
    <dbReference type="WBParaSite" id="TTAC_0000887901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000887901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000887901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000887901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22994" checksum="4A78679498023A48" modified="2016-01-20" version="1">MPSRRDQVRKSDSRKSGKSDQDQSDPEEQPQKSQRGSVKQKNQQQRSNDKGKADDQEDDPCGKQQQKQQQGSSQQHEGSVQQEETANELDNCAKCGQETSAGQVITLNGRKWHPECFTCGGCCVVLAKVSFFLDGEKIYCQSCWARNVKSNCSRCDGEITPDSTVVNFGVRRFHKACFICSRCRCDLAGLQFCIKGNQFTCQQCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6T1</accession>
    <name>A0A0R3X6T1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9217</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020720">
        <property type="protein sequence ID" value="VDM33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6T1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6T1"/>
    <dbReference type="WBParaSite" id="TTAC_0000923201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000923201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000923201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="213"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="678"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000923201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="789" mass="86267" checksum="3C7969BB52FE1203" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6V7</accession>
    <name>A0A0R3X6V7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9245</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020730">
        <property type="protein sequence ID" value="VDM34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6V7"/>
    <dbReference type="STRING" id="6205.A0A0R3X6V7"/>
    <dbReference type="WBParaSite" id="TTAC_0000926001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000926001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000926001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000926001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="7805" checksum="C7E35C616CFFADD9" modified="2016-01-20" version="1">MLEEQQRVSESDLVKAAASTMAALGGGDDNATDTSTKENSSSTNAAPSTEDKPSTSIPASALLLGGLAGVDEEDNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X707</accession>
    <name>A0A0R3X707_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9303</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020753">
        <property type="protein sequence ID" value="VDM34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X707"/>
    <dbReference type="STRING" id="6205.A0A0R3X707"/>
    <dbReference type="WBParaSite" id="TTAC_0000931801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000931801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000931801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000931801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51078" checksum="236F76C982A1AA66" modified="2016-01-20" version="1">MSVDASRDPRLLREAQEGSLLQNSSRLLPFARQGKAFRHQIPTNAFPRSSASDEAALKDAVFNGDTDEVCRILSLPNTPNVNAPLEPRFLMVAAGRGFADIVGLLLRAGAEVDAKSFLTETTALMAAAAALRKYFHLIHLWFNSQGHTMATMVLLQWGADPEAANAKSETALLLAIRGEHMAVVGLLLAYGANPLPSAAALRAKRCLLPLQLALHLGNTAIQEALIAANRMMDQYLINIVRASLPPGVILIDPGHPNTQQSITPRSLSFIPVQMVSNVKSTALLQLTFNTPPCYSDHFSSISRGSAMDELILLYVVCVDLQDGQVIAPRCSQSMPVYNLAYFNGSHTPSVCLTPMRNFKTTNTSSNTSPIDVDELPGFRVFVLGSRLNKGGLNSITVYQRWDHETQVSSLFQKLLIGIYRVRVELSAFSKGMSADIHGEIPTSVAVDGANDKIGNDVDDDDDSGSEDNTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Q3</accession>
    <name>A0A0R3X7Q3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArgoN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020891">
        <property type="protein sequence ID" value="VDM34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Q3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Q3"/>
    <dbReference type="WBParaSite" id="TTAC_0000957801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000957801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000957801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000957801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33915" checksum="6D29D8A7B6371DC3" modified="2016-01-20" version="1">MSHLTAEIDKSCDRYPRGMRHISQRDDGCRGTGGSSLKNTELRFNILKSAVPGPGAHDIKSNLSGSEYDPCDLLMPYLIYVKKPKIPIRYVDRTFPSIIATLDAHGYEMGQNGQLEPRRVQAQFCTDESVGSKHEACQRYRGCKWGSRTDYRRTFSPPNDYPGPGTYFTSLNDEWVQLIIRGLQRNLINSKHVLKIPRYIEKHVLDAKQENLPPPGLYFAEENVPKTPNPHRPPFASSASRFPPHDSSVPGPGTYNTNRDKFDSFCTLRNQKKIPFLSSDARMTKTDTNLIPGKSLLVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7R5</accession>
    <name>A0A0R3X7R5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9575</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020896">
        <property type="protein sequence ID" value="VDM34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7R5"/>
    <dbReference type="STRING" id="6205.A0A0R3X7R5"/>
    <dbReference type="WBParaSite" id="TTAC_0000959001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000959001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000959001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01794">
        <property type="entry name" value="Ubl_UBTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000959001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="668" mass="73224" checksum="EFCAC92709A25749" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X813</accession>
    <name>A0A0R3X813_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TMF_TATA_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9673</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020971">
        <property type="protein sequence ID" value="VDM34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X813"/>
    <dbReference type="STRING" id="6205.A0A0R3X813"/>
    <dbReference type="WBParaSite" id="TTAC_0000968801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000968801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000968801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277953at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="426"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000968801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="707" mass="77940" checksum="00FD3682830426D4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8T3</accession>
    <name>A0A0R3X8T3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021178">
        <property type="protein sequence ID" value="VDM34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8T3"/>
    <dbReference type="WBParaSite" id="TTAC_0000995801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000995801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000995801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000995801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10355" checksum="633E802AEBBE10E8" modified="2016-01-20" version="1">MSWTGLYPGIGPQAVLSSLPVEADAIGTNVWLFYGPDVRLCTALPTIFRATVEQAANKNDLNTEVQLMSITKIFIADINKFFAAFDTTNALALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X909</accession>
    <name>A0A0R3X909_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome non-ATPase regulatory subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10019</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021244">
        <property type="protein sequence ID" value="VDM34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X909"/>
    <dbReference type="STRING" id="6205.A0A0R3X909"/>
    <dbReference type="WBParaSite" id="TTAC_0001003401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001003401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001003401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001003401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54197" checksum="35A5C00839D07548" modified="2016-01-20" version="1">MALTSAAGFISLLDDERQDIKAFALKRLTDLVDEFWAEISESVDKIEILYEDTTFAYHKAAALLASKVYFNLGEYDDALHFALCAEELFDPNAKSEYVRTMITKCIDKYTSIRAEDENNPGQKLSAKDLKSSGRKWSVGDGSTYYQLETVVNRMFNRCFAHKQFKQALGIAIETRREDTFEQAILLAEDRDDMLRYALKVVLTLVDSVKLRNRLLNILVRIYSKNPTPADSVHICQCLVLMDDSKATAEALESLILLSEEAAVTAYQIGFDLYENATQQFLHQVSAALSHSEKIGHLMERPKPVGNEEGDTKKSEEGATGEPGPAEQSSEEDLKTELSSEDKAVKKRLELLQSILSGDKVIELHLQFLIRNNKADLRLLERIKEDVRNSVTHNATVITNSLMHCGTTSDQFLRDHLTWLGKAVNWAKFTATATLGVIHRGNEKEALRLMSAYLPKDSSGSSSSVYTEGGGLYALGLIHANHGGAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9A8</accession>
    <name>A0A0R3X9A8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10118</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021327">
        <property type="protein sequence ID" value="VDM35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9A8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9A8"/>
    <dbReference type="WBParaSite" id="TTAC_0001013301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001013301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001013301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6357972at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001013301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34379" checksum="F1470F754F0FE594" modified="2016-01-20" version="1">MQNDGAFCNCLIDVDGTIFKVHLEILCASSEYFDNIIRRDSVVEDAVSLHNITPSTFSTLLTHLYTGRMVVNLSNLFDVYVAADFLILNSALDYCRKVLCENLRNEKSSEAFDVALEILSRYDDAALFESFVSRRNLLKRKDPTKVIHSSRTIATMPTFEESLVIFRADVEYRNIWTGERQMAPSPLEEFMLSSYEVKELELEEGETLSRIEVHSGWLVDKMAFVTSTGRYVGPFGYSNGGGVLKVAVNKCHGSRYASSEPVYTCLALHGFSYSLIRTQGCPSWFRVCFLYAAVEGRCNFTMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9E7</accession>
    <name>A0A0R3X9E7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10157</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021364">
        <property type="protein sequence ID" value="VDM35137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9E7"/>
    <dbReference type="STRING" id="6205.A0A0R3X9E7"/>
    <dbReference type="WBParaSite" id="TTAC_0001017201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001017201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001017201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001017201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54262" checksum="2FA32210E7AD5461" modified="2016-01-20" version="1">MIVGVRSGDEASEESVPIPSTALKRLPLQHGTGGRYRLDLRQAPFRLFNNYLVPISNTEEATDALRAVAESITVLLQSIEASVPLEMQVTSISVRQRWFASFPPAKFTRPLPPAVYNVLQQHRDCLHPFLLSLQPPPRPRRSRHAPMANRNYLSRPAQRVWGTKSSPKSTLLSNVSQIELEMACVKAASGEMNEKLLAPDYTEAMEEGSRGTDETSEQEVEPSLGSDVDDMPTRIMKPSNCSSISDLIYELEDAASVAAEGEAEEGERMEEDEKAYRLRISRSRSRSVPAHLEDTTCGQMLKLTNPTIVASVSRSSSSPLLGCLFHHSLSPQSQIYERRSSSSRTYMKLSHPTLTGEDRLVLPRSSSCNDCNSRMIHRLPYRRIAVSDPEITCYRALYGLTVEQRPPPKSLHVSQSKGDLGLQEELNMRFQIFTFASIGRLQESANPRFVSRLRQRQEANASAVNQARNLICSSEDVIKTQFIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9N5</accession>
    <name>A0A0R3X9N5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10245</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021467">
        <property type="protein sequence ID" value="VDM35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9N5"/>
    <dbReference type="STRING" id="6205.A0A0R3X9N5"/>
    <dbReference type="WBParaSite" id="TTAC_0001026001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001026001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001026001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001026001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="11907" checksum="CF82ACBF8076A83D" modified="2016-01-20" version="1">MFLSISPEVDNPDELSGGEDQSSASVEVQNSSGASPTTSKRPKMAEKIAPSQPSQTYTIDLPDAPVDEVHPLVGVPRKHAGGKSALGHGYGGSNKGGEFSDAGSFRKGRNRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Q4</accession>
    <name>A0A0R3X9Q4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SLAIN motif-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10264</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLAIN motif-containing family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021487">
        <property type="protein sequence ID" value="VDM35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Q4"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Q4"/>
    <dbReference type="WBParaSite" id="TTAC_0001027901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001027901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001027901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9943255at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026179">
        <property type="entry name" value="Slain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15301">
        <property type="entry name" value="SLAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001027901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="44697" checksum="346FABA7328A8E49" modified="2016-01-20" version="1">MATATAEPHEDLACVQNLALEHHNYYHAEQSTSESSGIPAATGANASSRCQNKPMEDIPEEECWLFKPSKVTGSSLFLPNNSSLLWAREVFDSPSSEFYHRRRDLLNRLEFILATEPAKRLPNLGGSVPALNTTPTTVAPTPLAKSRAVGGGSGQNFGPGSSATFVRPKRHASEMLPQHSHQRSSPAGSHSPVHFKTSSGSTDDLQNVADLQSMARKQEDELKAEVAAISAHQQASRMGGSQQSLNSANRSGQESPYNSQSRLNISSSPSPSDIAKQQMTALRLSFDSQRHASALPRGGESDENMIVGGEASITSPGLRNSLDPTQTLLVDNVPPPGAQQAVIVGRPIGKMVSRLPAPMRRGPRFPSTETLPSFGWGDGLYGGGPMRRSSQEQLAARRIPVPPPRSGSSLSGMGLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9V2</accession>
    <name>A0A0R3X9V2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10312</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01021536">
        <property type="protein sequence ID" value="VDM35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9V2"/>
    <dbReference type="STRING" id="6205.A0A0R3X9V2"/>
    <dbReference type="WBParaSite" id="TTAC_0001032701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001032701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001032701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001032701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38221" checksum="707D133DC18B2EFA" modified="2016-01-20" version="1">MLYIIGLGLSTIEDITISGLNAIQECDYVFIDAYTSILTHGIERISAFCGKDVKRADREFTEQGSLITSLAKSENVAFLVVGDPLCATTHTDLIIRAIKERTPYKIIHNSSIMTAVACCGLQLYRMGETVSIPLWTECCCPESFYAKIIFNYSRGLHTLCLLDIKVREKSLENLLHDRDIYEPPRFMLCPEAACQILEAGRRIRQRFMAASMDPGAEVSYEPKPERYLHPDCLVVCLARVGSPTQAILATTMGILAAAASSGDSDILSHILGGPLHSMIIPGKLHPMEIEFLSARLLIGDGKVDLENVPNGTSLPVLLPPTMAGFDFRERVKSMFDRHQELLSTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAC2</accession>
    <name>A0A0R3XAC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10482</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021750">
        <property type="protein sequence ID" value="VDM35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAC2"/>
    <dbReference type="WBParaSite" id="TTAC_0001049901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001049901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001049901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001049901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42317" checksum="0599FEE440625AEC" modified="2016-01-20" version="1">MDSVKSASEGFRSSLAINICFNPTAPILRAALPALMFTILSFILLWALPCGPQLISIAQGILNLLYLATWTHYAGVFPTRFTLVDAWFILCLGFIGVAFFITLYEHRRLDRLCAGGFCGAGGGFIGLGNGQANPMGSGGSPPSMGLMHQPSPVTMPTKFDICNEAYFRSASSELSKDSSAVMSLGTALRLRCAKNGGLSVFEPNDSNLGPIKSQYASSSTPGDTTALNGCFLQPLGPIPPSYCTTVIAVALPILYILAVIVFWGFFGVQGTVPKACLGLRRMLKSSSLWVKVRISTNSKFTRSLEASHPDYAWQIVVTTRSEAWISVRRSTICIQHDDHFRKQRDINEESLLVRFCPGGILKPVERTQTEQHVRPLRKLEVEKIMVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAF9</accession>
    <name>A0A0R3XAF9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10519</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021795">
        <property type="protein sequence ID" value="VDM35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAF9"/>
    <dbReference type="STRING" id="6205.A0A0R3XAF9"/>
    <dbReference type="WBParaSite" id="TTAC_0001053601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001053601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001053601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001053601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33409" checksum="A90BE7FF3A637F14" modified="2016-01-20" version="1">MAKTDRTWECEFCYDQNSKCKNAGEPMMQKFASQEDLVQHIMHHHLLKRVEHGRTVFVCTYGPSGLCSSADAFNSQSKKPATFDSEYDYERHLVTRHIIGSGKSLVPSRFRKPSVLSSRKCVVVLHLGRKHLSIHAVLDIFSRYWGDTFEREPIPSTRFPIINRDEFLPYLNLLSKRKSFVTSPHPPAKLLSSQPNPLELEEAKVYCSPDFDLSSPETFNRVIPLYRRGVCPNLVRVFTQQSDQLSQYLDAVELAIVNHVSERSPAFFEAVREHDVVKDQLSQTISGLNAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAN4</accession>
    <name>A0A0R3XAN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021912">
        <property type="protein sequence ID" value="VDM35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAN4"/>
    <dbReference type="WBParaSite" id="TTAC_0001061101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001061101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001061101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001061101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8892" checksum="241EA7967491EE8F" modified="2016-01-20" version="1">FAEADVENAPPVSWNNAALLFPLSSRLTSTLPKSQFTVEGKFIVTTAAVAAEELSENDSHKVEDWLKLVRSTGTMRINCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAX4</accession>
    <name>A0A0R3XAX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cohesin loading complex subunit SCC4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10684</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022051">
        <property type="protein sequence ID" value="VDM35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAX4"/>
    <dbReference type="WBParaSite" id="TTAC_0001070101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001070101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001070101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001070101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10031" checksum="937558BAAD755CD1" modified="2016-01-20" version="1">MNKSEEQPLSTAECILNKPSAALTFQLAMQLREYTRDNDSNLTQALKRLVQVHSPLLKRDHVLYSLSLSLSLVKLGHVESNVEQVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBU0</accession>
    <name>A0A0R3XBU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CSRNP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS11000</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022709">
        <property type="protein sequence ID" value="VDM35980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBU0"/>
    <dbReference type="STRING" id="6205.A0A0R3XBU0"/>
    <dbReference type="WBParaSite" id="TTAC_0001101701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001101701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001101701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001101701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30405" checksum="E1C9A31154E0E35B" modified="2016-01-20" version="1">MEGSVFSPNKHDCCLETCTSGKISDTENPPPTSSPPLDGKRVRFSRTQIFYFLRQQGYSSVPQRGGCSLGMAQTHFHSETYGVHQYRRMSCSGNEMNLDTFSGSTQLYPRGRRRKLNCNRMPLTPVEDSVNPGDARRVPLFFSPPKLSPQTDDTGDLDGFSCVGGTPPPPCLSPQNEPIGCEFSTDPELSSFWQTDLEASIDLSLTKVGEKKLLPIQPTVRSRMLKQAGVVNIDESDRWTCATLRNSRASVGCGCITSSCNSEACSCALAGVPCQVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC76</accession>
    <name>A0A0R3XC76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TDP43_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11136</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023038">
        <property type="protein sequence ID" value="VDM36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001115301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001115301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001115301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001115301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18165" checksum="293933876400F6D7" modified="2016-01-20" version="1">MGAEGEISKVKSKKSRKATTMETTSPVPVTTPEAVSKTGLKCHRGDQDGQDEAQNQSKLPVFLRDDYSSLTFDEMDGKAMAGSASHESNGTTPVDTGLSHRVAKPVNVVRPTNGGSYRAVTASYISAEDALAVGISSPHARLVXXXFLQKTPLLWVYLHPMQGWFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCN0</accession>
    <name>A0A0R3XCN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11289</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023505">
        <property type="protein sequence ID" value="VDM36269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCN0"/>
    <dbReference type="WBParaSite" id="TTAC_0001130701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001130701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001130701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001130701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16627" checksum="71565BC525B76DE6" modified="2016-01-20" version="1">MAGSVDPMRSLATPDAFRQQMREVERMGRREGDKLLTDQAGYQLFSQPEKPPPEFRLKSRPNVGQLHKLMAKNGIDWLRWKTVHLGASKEPKHALCAASPLSSANFGSSAPPFLQGTDSDHVAAGRVHSYNSIDGRELQQWNGNSLSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCN2</accession>
    <name>A0A0R3XCN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11292</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023511">
        <property type="protein sequence ID" value="VDM36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCN2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCN2"/>
    <dbReference type="WBParaSite" id="TTAC_0001130901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001130901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001130901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133276" evidence="2">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001130901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18356" checksum="AC030271E0AD9D68" modified="2016-01-20" version="1">MSLPGAGALCCLVCSLTCSAGWQHGMPWRFKHKARRSTLAAQPSIDDYEDEGNSDVEANRHNDLGPRRTSESLAETSESVPTEHHEYYRQHLRSLRLLLKRTGGAGNKNALATVSKSRRFSLPEPKPQYEEDDFEIIAILLLIINPLHRWSALITTYLFAHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD00</accession>
    <name>A0A0R3XD00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024059">
        <property type="protein sequence ID" value="VDM36407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001142701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001142701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001142701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001142701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14375" checksum="365D0448B95EFA34" modified="2016-01-20" version="1">MNSVDGACHQRRCGKAAQFTCLCPIGPTTTITITIATKPXXXSTTTTATTLVAAAAAAAAAVATETTPVPLTAVVWPQPLCPPTITNLTSTSSHQSNVIIGKEMVRRSVYSSQGCLLSQYARVGADSDIGVIPRHTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDM7</accession>
    <name>A0A0R3XDM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11637</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01026237">
        <property type="protein sequence ID" value="VDM37605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDM7"/>
    <dbReference type="WBParaSite" id="TTAC_0001165401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001165401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001165401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001165401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="42" mass="4917" checksum="F00BDEAFDAFF35E0" modified="2016-01-20" version="1">MLSDAKGLAVKSAMKLEEEEEEEEEEEEDEEEEREQEASRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REC5</accession>
    <name>A0A158REC5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7059</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020342">
        <property type="protein sequence ID" value="VDM31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000707401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000707401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000707401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="2014"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="2400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000707401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2431" mass="272388" checksum="5D0A1DDCF4A458D5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EBE4</accession>
    <name>A0A3P7EBE4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inositol-1,3,4-trisphosphate 5/6-kinase</fullName>
            <ecNumber evidence="3">2.7.1.159</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPK1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.159" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000588">
        <property type="protein sequence ID" value="VDM18633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EBE4"/>
    <dbReference type="OrthoDB" id="25308at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="10">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM18633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="285" mass="32052" checksum="EDA7D98E6DA6F1C5" modified="2019-02-13" version="1">MDAIALVSNRYSQLISVSHAARTFNLGNLLLYYRNVRSFIDDIVVVPSFCLCVGNRDLDIRSLQDANVNFPAVCKPLASHGKTAAHKMVILFKQSDLSLIKCHSVVQSFENHNGILLKAYVIGDFLHLVTRPSIKNLSKEYEPIFFNSRDVSKENSHSVLNNTHDVPSIEDLGIDKSLMKRVIDSLRVRLRLKLMGVDFVIPSSAERKHHLAIIDVNVFPAKIESNHLTISNLLLNFRTVKFAQPHFTLDYSCVPNFHFHLENLVRNMLDLPAVPLSAAAPETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EP20</accession>
    <name>A0A3P7EP20_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000330">
        <property type="protein sequence ID" value="VDM18059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EP20"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903:SF1">
        <property type="entry name" value="HYPHALLY REGULATED CELL WALL PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="91978" checksum="6022D1D070628351" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F274</accession>
    <name>A0A3P7F274_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="1">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01006548">
        <property type="protein sequence ID" value="VDM26446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F274"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="NADP transhydrogenase beta-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="217" mass="21793" checksum="F6190E7DC497D46A" modified="2019-02-13" version="1">MVGIAAVLTCVANYVTEAPIMFADPSLIGAGNLMKTVAYLGTWIGGVTFTGSLIAFGKLQGILDSQPLLLPMRHALNASLVGISTAGLAAFLASGGDLETPMVPLSMLLGGAALAGSVSGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFMLNNSLMTVVGALIGSSGAILSYIMCRAMNRSLPNVILGGYGTTSAGSKVTGLTVLGVLDEHILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FDL2</accession>
    <name>A0A3P7FDL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007441">
        <property type="protein sequence ID" value="VDM26944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FDL2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="84" mass="9776" checksum="38F39298341ED496" modified="2019-02-13" version="1">MVTSMKLLRHGFSGATRMFLNFFFAEVLFTCDFPGLSETFPVDYFFVSIFLTKASLSSFYVHLLAYALSDAYHFTVLWEDMMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FET7</accession>
    <name>A0A3P7FET7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020890">
        <property type="protein sequence ID" value="VDM34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FET7"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000106">
        <property type="entry name" value="Putative heat shock protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="269" mass="29769" checksum="6D722A8ED7B4B739" modified="2019-02-13" version="1">MRLLFRRSFLLSSMEEVDYYTVLKIDRGADGESIKKAYRKLALRWHPDKNPDNKEEAERQFKLVSEAYEVLSDPQKREIYDTYGKEGLTNGGVGPSDFSAFGGFPFHFRDPMEIFAQVFGSSLFDVFGPNFITPGVSRAHRSHAGSRVHRRQNPYEPSRRNPSSFHDSRDIMTPGGFGGGFFDDIFGGLLGGFGGMNGFSSVSSFSNSGSGGGMARSMSSSTRIVNGQVVSTTTVRENNVETITETVDGRVVRTETRPCANNSSIYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FNM5</accession>
    <name>A0A3P7FNM5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FNM5"/>
    <dbReference type="OrthoDB" id="6280985at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="273"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="411" mass="46759" checksum="8F66592055960002" modified="2019-02-13" version="1">MSRLKRPIKVKQEAPQSQANLEASRAEGQENRQPFIVAPHLCEDMWRLLLGFTVVMSYELEEMAVEDPKSEITELHMSIRNNFEFWGIKLDPFRYSRELENTAYKWVDTCETAPPLSVRYFFSEANVVSSPLFASVSSKWRSLMANESKAYNPATGECDVSTCDHYRRLIEPYYTEFACAVRYCPIGRFVPETSTLTVCLYKPGTNALIAPPFPHLPLFSAVVASSSDKHWMNVLMSRGKVESKIRPPTTGMERLLACFFAVMSCAYADAGTEKMKAGLIELHMSLRNNFQFRDEKLTPFTYSKELENLAMEWAKTCNKSEPKDPRYANLGNNVGSCPLYWPLVFEWSNRLSSQKKAYNPATGQCVGSPCEHYRQVVQPNNTKFGCAINVCSYTVPSRRSKLLSVCLYQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FRZ4</accession>
    <name>A0A3P7FRZ4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020357">
        <property type="protein sequence ID" value="VDM31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FRZ4"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="6">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="5">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19250" checksum="D4F0A13A6F3FE65F" modified="2019-02-13" version="1">MEFPSPHLLVDVSDGTTPNTLPGKTMFKPVRPYGSNFECADNTMDSIHDTRTKEGVWSPDIEESFFEALTVYPPCGRRKIILSEEHKMFGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRSGRTAAPMRNIQTSYLPSLGRVHFSNGVTNGEKRISSSSQNCGGLRCGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2024-10-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FSH7</accession>
    <name>A0A3P7FSH7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024345">
        <property type="protein sequence ID" value="VDM36613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FSH7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038905">
        <property type="entry name" value="ARMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21356">
        <property type="entry name" value="ARMADILLO REPEAT CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21356:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19876" checksum="61B6BD8D542CCB7A" modified="2019-02-13" version="1">MRLAYALGNVAGCCESVGGMIFSSKEGAIKMCMLCEEYAANSARAKSNPIIYDALIKLTRIIVNACVGAAGGIIAADTPECTSVLLRLLKISADTQSTNDELLINGLAGLNNITFYMTTTKEREILTLQTEVGQGNSNTKLYRSARNTCLIFGEVYGFGGTVVNACNGFRWSIWEGPGDLVWILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FWT4</accession>
    <name>A0A3P7FWT4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020446">
        <property type="protein sequence ID" value="VDM32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FWT4"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="162" mass="19335" checksum="3CBFBE94F6D9A9E0" modified="2019-02-13" version="1">MYSQGSDYYFSKIETFDRDELANSVSSRKKRRKEERRTRRLENLGIFIGKSSGKMLAKARRYSEYVSKLKSEDQEKSLDQAIIGIKVKTDLSKMQRSALRARKLKRKSSNRWKERNQKIQEERDVRQRKRQRNLQRRSDAKASKKYGRLVKKGHILPQLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G1A0</accession>
    <name>A0A3P7G1A0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle 19 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021186">
        <property type="protein sequence ID" value="VDM34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G1A0"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16772" checksum="0CE80107846F9537" modified="2019-02-13" version="1">MPFSASAHYSDKERWICIYPVYLNSRVTRSKGRKISIDQGVDNPKHTEICAILQNLGFRHLAENKVYPRERDSTETQNRWRIRVQLKNDDGSPCLPEYVSELCLTLQVSHSPIIVNTSGRDHSSSENASFWPRLWAARERWKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G5Z4</accession>
    <name>A0A3P7G5Z4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022055">
        <property type="protein sequence ID" value="VDM35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G5Z4"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="182" mass="18697" checksum="024CEDD32A9AA563" modified="2019-02-13" version="1">MRYRLMIDRTRMLDFIGPSFRPIYFLHQHRSSSSSPSSHLLPHTPNPHLIGSVDRNYFCALAVAIAFTCNRGGGGGGDDDHISTDLPTGGGKETTPPSPSPPTPPTPVPRPDATLSGSCCCCYGGGGGSGGGGGGSSLASSLLFLIHAINCLTACMASTCGCASAPFIKLLSVTTSSHDVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GN42</accession>
    <name>A0A3P7GN42_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002947">
        <property type="protein sequence ID" value="VDM23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GN42"/>
    <dbReference type="OrthoDB" id="6279655at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="105" mass="11965" checksum="E0A384BE19E9675B" modified="2019-02-13" version="1">MSEIFMDKWVTVGIACGVVLAVVIIIVIISLLACFIWRRRSEPAKPSKNRSDSESNLKEKSNSYVPNMANSTQPYYVQPSEDRKLAPSAEMLHYQYQRDRNSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GQ14</accession>
    <name>A0A3P7GQ14_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004224">
        <property type="protein sequence ID" value="VDM24748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GQ14"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="154" mass="18128" checksum="CEF24DEC6A309C93" modified="2019-02-13" version="1">MEGPQLPHRHRVCQSWWSPYYPHPRRLHCISQHRGSEGIHTGINVAHPRCYAICSCIYCPRLVSPLHRHLRPPTHPTWSRVHCHLRSSGDQDQPNCTHYGGLKADPGEETTLPLHSSSVIYHWMSNYRWRELRLGKHERVRRFEVLKRAVIKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJR2</accession>
    <name>A0A3P7HJR2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Teneurin-like YD-shell domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021846">
        <property type="protein sequence ID" value="VDM35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJR2"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="2">
        <location>
            <begin position="451"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="568" mass="65403" checksum="83B681491626B0D3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HLF8</accession>
    <name>A0A3P7HLF8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021831">
        <property type="protein sequence ID" value="VDM35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HLF8"/>
    <dbReference type="OrthoDB" id="6141236at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="379" mass="44510" checksum="C2B383314294AA74" modified="2019-02-13" version="1">MHSSSKAFRVLQRLLENHPRKEIAQLFEERYTDILDRYDKELRLIETTFTEGSRDSGHFAAVLGPHYLPPVSSAIYWVRNLQVRITSPMLKMLNIRRLMESDRGKEVQDHYLCLVKRMTCFEEGLFNGKFNFEVDFGNELVQIMEETKFLQLLGFPVPDMACCVALREKELLRQRNELSDLAEVVRTTLGHLSMVEVATLEDHIVKLRATLAPAWKQLNWTSLIIDSYLTKANETFDHFCSVYLQQMADARMRDFEELARKHTEISTLLLNLERTITDKAATGREPKMVYLYEYWERRCFDTVHQMLAENLRRYLDTLQFPTQTLFGVDLMLSGCEVVSSPQPTEFYQHLIQTYNPLPSRPTDFFRLSDHRLQEEEMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HMF1</accession>
    <name>A0A3P7HMF1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022506">
        <property type="protein sequence ID" value="VDM35892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HMF1"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="107"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="325" mass="36115" checksum="87FAE6CC94939E67" modified="2019-02-13" version="1">MTESDLEPYKDFSLVVSERWQLEIAETVFDVVNQETDRIENKRRSKQQHQVSQHSVAPSSNTAPTSNTSPFTSSSSSQKVLSTSSSDYSAGEISISVDPHSAQLNSDCIVEGDILKLVGPFFQTWQRKFLRLFPNRLEIHSKSRDGTVVKKGVELVSMVDIREISRDFQRMYKMDNCLTITLKNDSKITITSTDKVLITQWKEEIEEAFQTSNQLISNLNKKAHKVYGAESPPQPSTPEQLATRTPTRSNPAAATESIGMQNLVRQTSAPSVGLQKSLNKLYSFTTYSGGASGHFERSPAKSMVGPIAEGDGENREGYHSSRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI26</accession>
    <name>A0A0R3WI26_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HDNR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI26"/>
    <dbReference type="WBParaSite" id="TTAC_0000022401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21595" checksum="3D20A0B84974DE7D" modified="2016-01-20" version="1">MPSNVELKCTPLPSLVDSSDIDPFTQRPRTYKGPRGGSPVIFREQCRNAPGPLFNEVKPVKDMDHFHRVSYTHKVPRSVLYHTDGPDFIRVGSRFEPCPEAQHDGAPYGAAIQWPPYRAGSFPEYWERSMLPINHHGLLVFPSTSKTLHEYQEEDARNVAYVKQLKVPTEYQERYIARIPVPHRQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI50</accession>
    <name>A0A0R3WI50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein tweety homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS253</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000017">
        <property type="protein sequence ID" value="VDM16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI50"/>
    <dbReference type="WBParaSite" id="TTAC_0000025201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000025201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000025201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256739at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="941"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000025201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="979" mass="108890" checksum="98A6B815CC2E7526" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WID4</accession>
    <name>A0A0R3WID4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase_II domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS354</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000028">
        <property type="protein sequence ID" value="VDM16297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WID4"/>
    <dbReference type="STRING" id="6205.A0A0R3WID4"/>
    <dbReference type="WBParaSite" id="TTAC_0000035301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000035301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000035301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000035301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="705" mass="76418" checksum="47A3B9A2213378A3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIX9</accession>
    <name>A0A0R3WIX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ADP-dependent glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS590</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000061">
        <property type="protein sequence ID" value="VDM16709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIX9"/>
    <dbReference type="STRING" id="6205.A0A0R3WIX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000058901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000058901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000058901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5847021at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF1">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000058901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="610" mass="67127" checksum="9FD463067D84FEF8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ48</accession>
    <name>A0A0R3WJ48_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="1">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000076">
        <property type="protein sequence ID" value="VDM16819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ48"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ48"/>
    <dbReference type="WBParaSite" id="TTAC_0000067401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000067401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000067401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000067401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36876" checksum="36F7B22C72E9AE13" modified="2016-01-20" version="1">MAKASEALRATLLRVSKVECLDALVSSGVVGASTKPTLMQSSEDRAQYERYSLAKSDLIENLRKFVASGATYKNFHRFLPTPKQSFEWDLILTPRVDSLEALWRDYLISRLAVERIDETAGDIMSRILQVAFAYKEHAHVTSFSSEAVDHLQLERRLLIPQKEFRQTLPQMVASRFVSTTEFSRAKDFNADTVVCLYSVNLSALARLTIEYAQHCILCLATRSDAELNAKSRLVDQRYRVETMVSRHQEEITKLEGGGEVSEGAKVEIDCHKESVQALRNSLTPAELNQLSTLSNRLAKLAAAQWEAETAWFVADLYLRLYFDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ70</accession>
    <name>A0A0R3WJ70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000081">
        <property type="protein sequence ID" value="VDM16868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ70"/>
    <dbReference type="WBParaSite" id="TTAC_0000070201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000070201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000070201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6239008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000070201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13076" checksum="31EB25AFA359BE6C" modified="2016-01-20" version="1">MAAAERQSQPPAWKAEALRRKLENERSKDVERRWEHLINTDGADAPEWMRETALKKKAARANLTANGIPPWMQEMQRRNDNLTKKMKEAQKVEEIDPAERAPTSTANLDATNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJC8</accession>
    <name>A0A0R3WJC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS773</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000095">
        <property type="protein sequence ID" value="VDM16973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJC8"/>
    <dbReference type="WBParaSite" id="TTAC_0000077201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000077201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000077201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248239at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000077201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23709" checksum="1495D2670D677B2B" modified="2016-01-20" version="1">MGDIIGKCAKKTNEVHIVEKWPRRQRTEAGHLDEDEPTKNNSNAKAKAKAKEDDSGSEFHEEPFLSTTTSSSMSSEGLTSHALRQNHVSQHPPPPRLQILTEEAEKADQRWYTKTVWLDAGVHCWLWVDEEKAAMLFKSGDRRLISIARRCNCLIELGSNQRYHIHKGLQRRIDIYAHDDRSLTKCLNLLEETFWSFRLRNLTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJI1</accession>
    <name>A0A0R3WJI1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS831</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000107">
        <property type="protein sequence ID" value="VDM17050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJI1"/>
    <dbReference type="STRING" id="6205.A0A0R3WJI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000083001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000083001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000083001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="6">
        <location>
            <begin position="79"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000083001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="752" mass="84929" checksum="6A0E7DA61D103882" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJL3</accession>
    <name>A0A0R3WJL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000115">
        <property type="protein sequence ID" value="VDM17106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJL3"/>
    <dbReference type="STRING" id="6205.A0A0R3WJL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000086701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000086701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000086701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="1">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000086701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11136" checksum="78E1DC926A5814C5" modified="2016-01-20" version="1">MVNISLNETLQSRIAFTRIGPKRIAGVALLTYLRHDPFIAATFLHELEDRVKEMLHSFAFKTRRYIANLGHGICPDVEPEKVAAFVDLVHRYSADGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLD7</accession>
    <name>A0A0R3WLD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Complexin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1562</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Positively regulates a late step in synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000377">
        <property type="protein sequence ID" value="VDM18214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLD7"/>
    <dbReference type="STRING" id="6205.A0A0R3WLD7"/>
    <dbReference type="WBParaSite" id="TTAC_0000157501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000157501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000157501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229630at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22808">
        <property type="entry name" value="Complexin_NTD_CPLX_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.580:FF:000002">
        <property type="entry name" value="Complexin, isoform AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF4">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000157501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17991" checksum="6F439CE2ADD65BC4" modified="2016-01-20" version="1">RCATFAGALGDKKDESGSSGAREIDPEVEEALREAEQKRQEKHRRMEEEREAMRQDIRDKYGIKKKELEIDFDELMMTNEGGRVGRKRKTPAELAAEADRAVADEDSLIGLCTTEKVLAKHSQSLPFRLGMLPENMRGIASKVTEAPGKLISEATEKCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLJ3</accession>
    <name>A0A0R3WLJ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1618</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000407">
        <property type="protein sequence ID" value="VDM18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WLJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000163101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000163101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000163101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000163101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16408" checksum="993FCA0E9BAFAD98" modified="2016-01-20" version="1">MDPIWRLASLFDGALAEVVIRASDKDITNERRIFCPPRQSIRACEMKRQGANELLLLSQNRCADAFWLGNLKNRDLAGQEIHDGDVSARHSGRTTISTASVSSRGSNSNARSYTIEGAEELMSEDESDVEEADLSTDDTEEGEEEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLU1</accession>
    <name>A0A0R3WLU1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF862 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1716</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000464">
        <property type="protein sequence ID" value="VDM18435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLU1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000172901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000172901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000172901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000172901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22417" checksum="DBD63A2DF60FBA60" modified="2016-01-20" version="1">MAMYGSPTFSNSVAESSPVTVNVYDMSWLNEYIGNIGLGVYHTGVEVYEREYCYGGHQFGGSGIFEMTPRDTENLGPNYSFKLATSIVVGFTDFTYRDVCAILSNMERDFRGAHYHLLRKNCNHFSNAFIEILCGATLPKWINRLAVVSTKLPFIEKSIPKEWLTPLQQVGFFHDYPFFCVLEHACEVFGGKHSCVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM03</accession>
    <name>A0A0R3WM03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1778</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000503">
        <property type="protein sequence ID" value="VDM18518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM03"/>
    <dbReference type="STRING" id="6205.A0A0R3WM03"/>
    <dbReference type="WBParaSite" id="TTAC_0000179101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000179101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000179101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059177at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="190"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000179101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="30709" checksum="FA69D200A7C3113C" modified="2016-01-20" version="1">MSLYPSLEALTIGKEVDAQNKLATALMSTPAASNPAGGGVNYAALANEFLGLDLSLVTYDEYGNACYGGQPNAGAVSIHPGTAVAFPNSNAITNVDPVHVSQGVREVTVRKGKEGLVGLQLRDQDRGVFVTYVESDSPAAQAGLRFGDQVLRINAQYTAGMTGKDAMNFIKRSCGPTVDIVIRDRPLERVVTLAKDSLGSLGILIKNGAVEAIVKDSSAARNGVLINSQLVEVNGVNVLGLSDRKIRELIKISPQNVKLTLIPGFYYQHLSKKLGRGLMKNMDRSEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMV1</accession>
    <name>A0A0R3WMV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2078</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000736">
        <property type="protein sequence ID" value="VDM18854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000208901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000208901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000208901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256727at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132901" evidence="1">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000208901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21758" checksum="1103743C3F64FAE1" modified="2016-01-20" version="1">MSFLHMCCKLIILALLFVSVAIACVSREEDVGIELSPDSGLIDNCPEVVDVDKEMPRIVSHLVRKALTSVVFTLNRMGRKARGDCSKASFQSLCRASKTFPNKYECTVVVRHLKFDCASHTGPLSAVEAKLVNDHFINQVVMNIVVAEEEEIIRVTDVMSFEADVSGMRGIPGLRESALQRAMLAGLKVATGSVSCRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMW3</accession>
    <name>A0A0R3WMW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2089</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000746">
        <property type="protein sequence ID" value="VDM18885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WMW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000210101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000210101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000210101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000210101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1410" mass="157335" checksum="E6635B0772A82501" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN87</accession>
    <name>A0A0R3WN87_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2212</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000855">
        <property type="protein sequence ID" value="VDM19256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN87"/>
    <dbReference type="STRING" id="6205.A0A0R3WN87"/>
    <dbReference type="WBParaSite" id="TTAC_0000222501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000222501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000222501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001346">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF631">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000222501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="728" mass="76940" checksum="DF6C745D982D8D15" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN89</accession>
    <name>A0A0R3WN89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SF3b1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2214</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000857">
        <property type="protein sequence ID" value="VDM19258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN89"/>
    <dbReference type="STRING" id="6205.A0A0R3WN89"/>
    <dbReference type="WBParaSite" id="TTAC_0000222701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000222701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000222701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000438">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="244"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="811"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000222701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127354" checksum="73EE049F94A0930B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNF4</accession>
    <name>A0A0R3WNF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2279</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000922">
        <property type="protein sequence ID" value="VDM19494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000229201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000229201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000229201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000229201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12858" checksum="83E6B972217260D5" modified="2016-01-20" version="1">MNVGRDDHTHLIEFTGRSTSVVGKPGPSLFIRLRFQPPRMKQKTCVHIECGGELSAIVEYLISIQSYLLAYHFYPLLVTFYELLVMYHSSAFLQQTLGVGTEKERGAMEKGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNQ0</accession>
    <name>A0A0R3WNQ0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2375</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01001011">
        <property type="protein sequence ID" value="VDM19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNQ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WNQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000238801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000238801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000238801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000238801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47262" checksum="C42FEEB64C6391A3" modified="2016-01-20" version="1">FDPPPPRRKNGAVGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTERAYRQEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPADAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNQEDPQWCYDNFINLRSLKSADNVRVQLSRIMDRFSLRRSSTEFTSRDYYLNIRKALVSGFFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTVTEVKPDWLIRIAPQYYDMTNFPECEAKRILERCAHRIAQRQQKKQQQQQQEEENKSEEAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPI5</accession>
    <name>A0A0R3WPI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CEBP_ZZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2660</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001341">
        <property type="protein sequence ID" value="VDM20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPI5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000267501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000267501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000267501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132974" evidence="3">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic polyadenylation element-binding protein ZZ" evidence="4">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000267501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16166" checksum="27A62530A40BCA6B" modified="2016-01-20" version="1">MLIFTLVELALIMDHLYGGVCYAGIDIDPELKYPKGAGRVAFSNQQSYISAISARFVQLQHNDIDKRVEVKPYVLDNQMCDECQGARCGGKFAPLFCANVTCLQYYCEQCWVQIHSRQGREYHKPLVKEGAERPRPALYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPR1</accession>
    <name>A0A0R3WPR1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2736</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001450">
        <property type="protein sequence ID" value="VDM21032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPR1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPR1"/>
    <dbReference type="WBParaSite" id="TTAC_0000275101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000275101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000275101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000275101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="61283" checksum="D6F06002F0484F1A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQF4</accession>
    <name>A0A0R3WQF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2979</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001764">
        <property type="protein sequence ID" value="VDM21669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQF4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000299401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000299401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000299401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="245"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000299401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42636" checksum="04CAC0B944ADF9A5" modified="2016-01-20" version="1">MRANDYDKSVVNFTKKDSLTLKMVLHLWLILFTAFALPENGTGYFIPNLRWVYVGHNGLMLRWDTAQFAYQKVEWVRMVAELVDSPVEKKEESANMESGRITLYGFEPYTYYRVTVQGYRDGRVLFDLGSFIRTLPTAPAGVLPPTGRAISTEEIELQWLAPTRPNGILKPYVLTCFDVSNSWSPVSVTTKNNETLSVSIENLHPGTEYRCYVLASTVPGVGQISRYCERRSELSNPIRTMALAPSRIPRPKGKAISSTEIELTWSKPKHSNGILKPYLVTCLDVTHCSAPSRITTNDSETTSVVVGNLIPNTFYQCSVMTSTIPAIGQDATQCERRSELSTPIRTMSLVEFGRHISNPQGSGRRHHNLQPYTFKEGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQG9</accession>
    <name>A0A0R3WQG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2994</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Synaptic cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001782">
        <property type="protein sequence ID" value="VDM21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000300901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000300901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000300901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19033">
        <property type="entry name" value="LGIC_ECD_nAChR_proto-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="14">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000300901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36625" checksum="47C5BD8192C2B84B" modified="2016-01-20" version="1">MTIFLLLGNIDSCNASDKDFKFQSFERTLIKQLVERYERLGKIGRPVMNNNQTLNVQFGLSLFQLMDLDEADQLFTVNVWNKFAWRDEILTWDPKNYNEVKHVRIPVKHVWTPDIVLLNYADERLVELREVMLTVDYTGQIFWSPPSIYKSMCRIQMEHFPFDHQICYLRFASWTLHGRRLNLTFLDGIKSALLDDYQESNEWHIVAYPAVRRFFRQTCCDEPSPNLIFFFVLKRNPDFYAYLLVLPCILLAVLNLVTFWLPPQNPARMMLGQLFCLPLWVQVPRSMEHSHVGCCTDATTLGLKDTEDDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQT7</accession>
    <name>A0A0R3WQT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3112</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001942">
        <property type="protein sequence ID" value="VDM21977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQT7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000312701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000312701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000312701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000312701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22947" checksum="E42E9ADA21512929" modified="2016-01-20" version="1">MSSTNTNLSTQLQSPDQLLYLCEVVQKSEDYARLHHLLAYCRDAAPPSVQQSDTVVKCLAVLALLEGRYQDVFAILQTRYFAPRHHARLQELWLRGHYEEAEQARGCSLSAVGRHRLRKKHPLPPTIWDGEETSYYFKEKSRRLLRQQYAENPYPSQWEKKELARRTGLTAVQVSNWFKNRRQRDRTGECLSPASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQZ5</accession>
    <name>A0A0R3WQZ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3170</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002016">
        <property type="protein sequence ID" value="VDM22095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000318501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000318501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000318501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788000at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM22095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000318501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51431" checksum="9A5B71ABB992D9DD" modified="2016-01-20" version="1">MFCSDAQTLAERAAPRETPPCFPEQVYATSNGIESGVSTIGFRSGRYAPEEARAALENRLALAQMDVDVGEKNRNDNKNMMAEAEERSKADFRNTTERLRERLTDLHMWKNEMENEILKVISMNDLLLNRLAELNTSLKALDECVLLTTDCLNARQRRFGEDLQQDEVELQLIKELDILNKAIALIKRSIEQVNDQLNRNRTAKTNLEKAWSDKHEADMLDTEGAHLTPESTNKQHYPGEARSWPQAAQSTVESWTQHAHDLILRSEHERIASDQLLHLCENILHDVERDVIQQKDTVNAAFQRRLDQYECEKKNLTDKLRKTCDEILKMENSIKDMENAIVAKDAYVQTVQTRLHLHNQRQNVENCRDPPQKAMLDEMHNIQETIDKLRNQLSNTENNLRHLQDEQLALEKQIHMKNASIQVDRDHCARHRMHFPAATRLRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRQ0</accession>
    <name>A0A0R3WRQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3425</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002420">
        <property type="protein sequence ID" value="VDM22603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRQ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WRQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000344001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000344001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000344001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000344001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17057" checksum="B444F9A63E6F9311" modified="2016-01-20" version="1">MKASASSPSMGTSSSSTDFTTVADSSTVAEEGVVTTSVCPRHSPSNSSDYDSDAELQMVYLRHMAKFMPASWLLRASQALQLNLNYVSCDSQVPWLNALIGRLFWDFLRHEIWHKRVQEKIQGKLKKLHVSSFSVCQRFASFIKNSFSTLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRU6</accession>
    <name>A0A0R3WRU6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3471</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002488">
        <property type="protein sequence ID" value="VDM22699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRU6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRU6"/>
    <dbReference type="WBParaSite" id="TTAC_0000348601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000348601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000348601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257497at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000348601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="630" mass="66413" checksum="3553009514B17A32" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS15</accession>
    <name>A0A0R3WS15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002609">
        <property type="protein sequence ID" value="VDM22834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS15"/>
    <dbReference type="STRING" id="6205.A0A0R3WS15"/>
    <dbReference type="WBParaSite" id="TTAC_0000355501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000355501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000355501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375837at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF38">
        <property type="entry name" value="LP13770P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000355501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31166" checksum="FDEC6AB9C8EA8947" modified="2016-01-20" version="1">MIWPCGFEQPDSCHGVRCGYYARCVEGRCECEPGYAGDAYTECRPEVNPDLCEVLGCGANAVCLNGNCTCRQGFTGNPYESCVEIQYLKPAVRTLHDPCHKVDCGEGAFCYLGTCRCPEGSHGDPYTECQLDIAFLDDCRGRRCGSNAYCRDDVCHCEAGYQGNAYIGCVRMSDGCDGVQCAPNAYCENGYCRCNPGYIGDGFIECQYQGSCANVQCGTNAHCVDGRCVCWPGYAGDPDRRCDPSVDPSYCDGRRCGKNAVCDQGRCVCNYGFEGDPNYGCTEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSI5</accession>
    <name>A0A0R3WSI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3710</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002905">
        <property type="protein sequence ID" value="VDM23198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSI5"/>
    <dbReference type="STRING" id="6205.A0A0R3WSI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000372501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000372501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000372501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249345at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MIR" evidence="2">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000372501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15545" checksum="B0097B6C6EDF180D" modified="2016-01-20" version="1">MISLVPPANMPPCIFILEQALSARALQEMLSSRNELSDSHTSGHRTLLYGHAIRLKHRNSSMYLACLGTSSTEDKLAFDVGLEREANTEACWWTIHPASKQRSVGEKVRIGDDLILVSVSSERYLVCFYFSPLSMHAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSY4</accession>
    <name>A0A0R3WSY4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RPN13_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3859</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003174">
        <property type="protein sequence ID" value="VDM23598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSY4"/>
    <dbReference type="STRING" id="6205.A0A0R3WSY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000387401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000387401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000387401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEUBAD" evidence="5">
        <location>
            <begin position="84"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM23598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000387401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25903" checksum="15695523C95F0FC4" modified="2016-01-20" version="1">MAVDHVMRITMIWCHALSVNRTTDSISCGHFANHLEKKRIHVQEHAFVPTHTCKWDFIDSNRFLNLFRMGIKPFLCEILTLIGFGESGRGVDITQGLSVDTLTELMDKKPDLAERLAAHLPPIDPEDQQLTPTQAVITNIRSPQFKYALKSFSEALESGQLGPALSKFGLDEEVIKSADTGDLEVFASALQKSLGTEKQQPESTATSIGETTNKPEDDGGADEKDDEGGEKMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH4</accession>
    <name>A0A0R3WTH4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4048</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003559">
        <property type="protein sequence ID" value="VDM24061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000406401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15062" checksum="4F3F2608E8D347E8" modified="2016-01-20" version="1">MSNPNIISTSDGSKQLITFNKTQQKIVRQNVRSEDEYLSHIGSIIQRDFFPDLAELKGEAPADEIVEGSETPPGPPTQNPQRDATAVRLDTYLANNTTEDNASFIEIIEESERKREAKLAKFFPSRSFDSSLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTU4</accession>
    <name>A0A0R3WTU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003828">
        <property type="protein sequence ID" value="VDM24350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000418401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000418401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000418401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10601237at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000418401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="50296" checksum="F8D4423694C2166E" modified="2016-01-20" version="1">MEGLLEATRRGNTATASRVQGRFLPISDPRTIRGLSSRQFQHHALLDPPLHQPYVNNGDDLVDDDEDIDFFGPHPLLAHRRINSSESLQQHVFRQGLFPSTTYHRGYARPRGNNPAVGNVVTGGPSGGGAGGPNSGVFYDTRNPHLALDPLTAAYRGSVLSSTTVSSNQDELMQAYEYGRKHGRFLAAVGGTVTTAAVATTASGDVGAVAPSSTVANAGGGGSGSSETTDPGICQFTQQPPMPDEMDGRLPNGVQAGTIEVSRRGAPSARPGLAAMAIASEALPPAFLKRQLSECPSEMTDTYASVDYSAIGAAQSRAVVPLRGGLSSKLPTIPQNQQLLAARIEFPDLESDSGMSGLARGAIPMPGYHRQSSQHSYYYPTTATAAVAAVGGSYYGQPVGRQHRSTMGASIVRRQESMTGVGGGGGVGGGGGISRSRQQQQQHYQSRKGIARGISNNNASATSTGYGSAPRSVVAFESSDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTV1</accession>
    <name>A0A0R3WTV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003841">
        <property type="protein sequence ID" value="VDM24362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTV1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000419101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000419101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000419101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000419101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="33613" checksum="5D19622D015A632F" modified="2016-01-20" version="1">MVSRKAALAHCRALTAACHYSEGDVMVCVVDCRREAGLWHAALSSVFNGMHVVFVPFNVLQMDPGSWIRMVTKYRASVAIVKSRDLHWALLAEREHPYCNLSSLRALLVTDGHNPWSLNSCDLFAAKFKTRGLNPNAICPIAGSSETLTLSLRRPIPTSSTTAPSTGGLFGLHSNGAPRGAPVLPTTNNASPQHTAPSSSPAAAAARGIISIHALSYGVIRVDSEDSFTSLTLQDCGQVLPGAAMVVVSLGPKPTVCQTDEVGELCIAADYVGTGYWGLRGQTGSHFCVQPIHEDGRPVVINTNAAAVPATAGALHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTZ6</accession>
    <name>A0A0R3WTZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4221</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003947">
        <property type="protein sequence ID" value="VDM24458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTZ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WTZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000423601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000423601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000423601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000423601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7268" checksum="D9123F1AD659EB23" modified="2016-01-20" version="1">MYLSDGIRQIDYVIAFSFSSPSVEEPFQDFLIALLHRGFNIEVSERMSHWLSYKLSPPKCALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU33</accession>
    <name>A0A0R3WU33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4258</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004027">
        <property type="protein sequence ID" value="VDM24545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU33"/>
    <dbReference type="WBParaSite" id="TTAC_0000427301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000427301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000427301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000427301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21196" checksum="C1B17CC5E5828714" modified="2016-01-20" version="1">MDLPDEAQFNVVALIQMVTRNFMQITNSMSDEEVLQLISQIAVAEMRLMEGLRLQLDSPIPLEAKAADGTSEGQENATTMSVEKRQKESVRRESQRNLASFRANFGHRNAVGISYMASRAIGELNAALTGAMELVATPHLAATTNEGGFMHFFKIATLPQLYEASAKLNKLSCASFSVLDLATLLDKCGTIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV58</accession>
    <name>A0A0R3WV58_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4633</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004931">
        <property type="protein sequence ID" value="VDM25329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV58"/>
    <dbReference type="WBParaSite" id="TTAC_0000464801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000464801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000464801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000464801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13365" checksum="95ECF36D7FD4EE50" modified="2016-01-20" version="1">MGGCVETPAWNEFSKYQSNEHMVSRRVVSTAGSGDWCGVVQCSAVQCGEVQCVVCGGGGIIMVWVNVRCGERKGRRMHLRFRCGWELGEKERMHLHQFERMRRSGGGGGGVGGGGGERGDAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVD8</accession>
    <name>A0A0R3WVD8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAF1C_H4-bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4713</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005155">
        <property type="protein sequence ID" value="VDM25508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVD8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVD8"/>
    <dbReference type="WBParaSite" id="TTAC_0000472801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000472801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000472801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000472801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26377" checksum="07EFAA37F16EBD33" modified="2016-01-20" version="1">MDDDDADADDDVEGEETKRETGEGQSNVAPKWQSVIQEKRRITLERVNGCGDALVAKSKVVDEVGQIENEHEEEDAEGEEEGEMKSNSANRMDKKKNVTTLFSRLGIRGTKQQKQQQRPVIVTPWRSEPSDDNPASSSSTVALATSSSLTASPPSREKNNPLQMWPSIASLHCIGWAKVTSSYTPQKSGELALLEGDLFACLMTLKWLWRFEGVPLYDARLRRLLSTPYLMSRYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVG0</accession>
    <name>A0A0R3WVG0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4735</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005204">
        <property type="protein sequence ID" value="VDM25552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVG0"/>
    <dbReference type="STRING" id="6205.A0A0R3WVG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000475001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000475001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000475001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257407at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM25552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000475001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19729" checksum="53CE4725D61E8333" modified="2016-01-20" version="1">LKCNGVLEGIRICRQGFPSRVPFQEFRQRYEILTPDLISKGYMDGRKAAELMVQRLELSPELYRIGQSKIFFKAGVLAQLEEDRDLRLTAIMINFQAHCRCYLAKKAVQQRIQDIQAIRIIQRNCVAYLKLRNWPWWRLFTKVRPLLSVTRQEEIVAAKEEELRMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVQ2</accession>
    <name>A0A0R3WVQ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ephrin_rec_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4829</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005444">
        <property type="protein sequence ID" value="VDM25731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVQ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000484201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000484201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000484201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000484201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53303" checksum="E0E75D2AB29B87E3" modified="2016-01-20" version="1">MDYELSRASTYENKGARTTLELPKAYSIDLGSSLDTLYRKTMTTVTCRTYRSQGAGLLKSAPLEERPFSMKEELVYNQYSLMHYVQPLVIWKYIIPERHQLKELLIPDWWRNEAELFCRELRHVRDFQVSPCATVSVNQITTSTPSQHKTLLSLAINLSSNPVNILLNPTRTNLEANVTLSYIHAVTKNMLDRHFIKAVSRELAFHNISMRIQFSIPTFTEVICPTGTQLKYPPNPLPQIVFNYPMNISVQSVDESPISPSESAYALSAVSLSCEACPSGRAPRTPYSFAPCSPCPRGLYRGDTGWPSASGCLHCPAGFTTLREGSTSPEDCVIDGGALTRAILGFAVWAYHNFMELIVAAHEASMSYTKRANLYLSEESKVNMAEESIHWINRIKPAALAVGIFYSLFVLLLLALALYRLQLIYHFKRTHSKHIYLLRKSIIIGQLNSQDDAKDLLRKDFTGVGEPHLAQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWP9</accession>
    <name>A0A0R3WWP9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006480">
        <property type="protein sequence ID" value="VDM26403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWP9"/>
    <dbReference type="STRING" id="6205.A0A0R3WWP9"/>
    <dbReference type="WBParaSite" id="TTAC_0000518901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000518901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000518901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000518901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34849" checksum="EDC16F427E828BD3" modified="2016-01-20" version="1">MDPLCADLPLKGFTWTRWGHFPEAVNTSLLNELCTRLCRTGAATTTTLSPRMTVTRMGMREDESIFRLVDDTDVTLGDGEDFCPSPHYVSPPLPFIHGNGVPEALGVAQLNSLLKRTVQETTDCLIAGQFCMTIKCPTSLGVILCYKVSAFKVTLIDSFAAVATATKRRNAGGAAWAEQLLSEVYSLWFLLLPAFIASLQQHSGGLNVGDGIGLETRRFLYRVVGVFLRLWESPVQPVDQVYVRVLIALLYEYGTSDEGVISFWSSRPLNAPSYAMANQLQRDLGHKLTSARTMEDGSESSTGNVNYSNSRRCGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWQ5</accession>
    <name>A0A0R3WWQ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006491">
        <property type="protein sequence ID" value="VDM26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWQ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WWQ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000519501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000519501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000519501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000519501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21453" checksum="2F7E20D432FECE51" modified="2016-01-20" version="1">MTLSSVIFRPYRSLGLVSSDVPFVVKYKPHSKEYNVLVPVGERFNIYQLPNLRLLGISDCLPTNIIAFTSDRSYVYGASKNVIYAFRGLHHIHFKLEGHNSPIRKIIAFEDRYLASYDEAGLFILWNLQTRESLSQTVFSTNVFDISSMCHPTGYGDKLLLGSSQGPLQLWKTLAKKSIYWFRGFDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXV1</accession>
    <name>A0A0R3WXV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5575</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008054">
        <property type="protein sequence ID" value="VDM27255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000559101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000559101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000559101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000559101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29734" checksum="0E957BAC4539EFD6" modified="2016-01-20" version="1">MGRLDDGEETFSLPTPPAGLKEMPVAVPHKFHLDGVQPPLAICSMLLCTAAIKTEYYEFFHQCSQPPTHTTHYCVEEANTWWIINETQVPSSSRIHQHVLTVECNRGMQLGVHREEASPVSSATALPAAPSSSLLLLCPQLYRLTPSMCNKKMLDVRVRLLVYLLPTSITTPYHSGTSQISKQVALVPQYCLLLQLLNADATTLPNGKVSLAYYKNCPQNEVTSGSILTAYSPVRRALPTKCPNVPQYLLAPYVRAKDMRVKEVNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXX2</accession>
    <name>A0A0R3WXX2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS5597</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01008152">
        <property type="protein sequence ID" value="VDM27300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXX2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000561201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000561201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000561201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="70"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM27300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000561201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29903" checksum="049EB9F58010BD00" modified="2016-01-20" version="1">MFRWRPAPWLENQSEEKSEKIRKRYRILVEGEAVPAPIRSFAEMCLPRVVMEELRSHSIVKPTPIQMQGLPAVLSGRDMIGIAFTGSGKTMVFALPILMFALDQESKIPFLPSEAPYGLIIGPSRELARQTQDVLTQMASKLADAGYPEVRIGLCIGGMAVKDQVDSFRRFGVHILVATPGRLIDLLEKKVFNLEICRYLVLDEADRMIDMGFEEEVRTIFSYFRGQRQTLLFSATMPKKIQNFAKSALVKPVTVNVGRAGAASLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYN8</accession>
    <name>A0A0R3WYN8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5863</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01009404">
        <property type="protein sequence ID" value="VDM27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYN8"/>
    <dbReference type="STRING" id="6205.A0A0R3WYN8"/>
    <dbReference type="WBParaSite" id="TTAC_0000587801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000587801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000587801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000587801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15969" checksum="49A3B567A16708EC" modified="2016-01-20" version="1">MKSKVTKQKSCTNFNFQAKRIIRVIAEYERAVLFRLGRILPGGAKGPGLFFTVPCLDMIRKVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPVVAITNVEDADRSTRLLAATTLRNVLGTKNLSDILSERDSISGMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X016</accession>
    <name>A0A0R3X016_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6420</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020303">
        <property type="protein sequence ID" value="VDM30628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X016"/>
    <dbReference type="WBParaSite" id="TTAC_0000643501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000643501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000643501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="192"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="313"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="470"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="598"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="762"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="908"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000643501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1361" mass="149348" checksum="05E8C2584592166F" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0G6</accession>
    <name>A0A0R3X0G6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear RNA export factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6608</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0G6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0G6"/>
    <dbReference type="WBParaSite" id="TTAC_0000662301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000662301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000662301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="8">
        <location>
            <begin position="400"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="9">
        <location>
            <begin position="615"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000662301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="670" mass="75092" checksum="025D3AAB8A503EC4" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0J6</accession>
    <name>A0A0R3X0J6_HYDTA</name>
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        <submittedName>
            <fullName evidence="3">Parkin coregulated gene protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X0J6"/>
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        <property type="protein sequence ID" value="TTAC_0000665701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000665701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000665701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34425" checksum="9DA63756BF4F1AFE" modified="2016-01-20" version="1">MRCTTSTGRICRRVTCSPKRLPLSFCETLREAEEARRHSDPCECKENKCGPQPRRIPLLGTEDPASEKSKRAFGMQAEQGIWDIGIPLSSRVQLPLRRSRFRVRYERGLYPFHLDYSADVFIERINWCVDIEQYDIADLLKDTLEAQSDDSHWAHVGHLVFMDLLKHLPPVKLAGALPSFSIEFRKMMRRNNEVTARRLMKMLKELALVVTSIGPELAFYAHDLFNLCNQWLEQYKEVGDRIVYEQKRNIHLNDLTDELHAIFEVVSGPEHDYAVAGMKLAIPTYRIPEKVENPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0R5</accession>
    <name>A0A0R3X0R5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020319">
        <property type="protein sequence ID" value="VDM30986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0R5"/>
    <dbReference type="WBParaSite" id="TTAC_0000674701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000674701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000674701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250032at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000674701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="740" mass="80658" checksum="215208151FD83ACE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1L5</accession>
    <name>A0A0R3X1L5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7093</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020345">
        <property type="protein sequence ID" value="VDM31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X1L5"/>
    <dbReference type="WBParaSite" id="TTAC_0000710801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000710801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000710801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF33">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="7">
        <location>
            <begin position="974"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000710801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1388" mass="152932" checksum="3D11B6A72731E414" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1S7</accession>
    <name>A0A0R3X1S7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-related GTP-binding protein RhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7172</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020350">
        <property type="protein sequence ID" value="VDM31509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1S7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1S7"/>
    <dbReference type="WBParaSite" id="TTAC_0000718701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000718701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000718701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000718701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30867" checksum="43849A2927D37FE5" modified="2016-06-08" version="2">MSEKSSAFVKCILIGESGVGKTSLVVSYTKDDYPVQHEPTAFDTYVVDLRVENRQVNLQICDAGGAPGVRSLRELAYPDVHVVIFCFSVVQPETLWALRDRWLPELAASGLVLNPSALETASRIGCLPPPNLSATVPRPLGPAFILVGCACDLRNDIKCLLDLSVRNELPVNEAVAHRLAVEFGAEAYIECSALTQKQLKKVFDLAVWYGLHAQQAMLGITSAGVSSRNSLSPHPLLGSGVSRKSKRRRHHSPTETTNQVVQHSNDLCASQRSIWKKLLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Q8</accession>
    <name>A0A0R3X2Q8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7578</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020385">
        <property type="protein sequence ID" value="VDM31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Q8"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Q8"/>
    <dbReference type="WBParaSite" id="TTAC_0000759301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000759301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000759301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267810at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000759301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31072" checksum="568DEBAC0294BF3C" modified="2016-01-20" version="1">MGKFPFIVSIQAKLSNDIYSRIFGGLEHFCGGTLIAPRWILTAAHCMFAYTDDGKQVSLLNPKAWHVRMATDKLRPSVIDRMKGLFHRAFNTLFGYRKPQTFYHLEKIILHPDYVEGFLENDIALLKLKEHVLVHRMKLLDVLPLPNPHIVGKMWPKTGQNCSAVGWGSACINCPPEMYMKVVNMPIISPEKCRGMFKVSINLTETNEFCAGYFKKNIGICSGDSGGPLVCEFEGERLLAGVTSAIHAKKPENYPAVFTRVVRFTDWIFETMGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2U2</accession>
    <name>A0A0R3X2U2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7615</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2U2"/>
    <dbReference type="WBParaSite" id="TTAC_0000763001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000763001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000763001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265759at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000763001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49806" checksum="F03B3EDAA0FE81CC" modified="2016-01-20" version="1">MERDKWVGSAYRVCSLKSSIQGVFSHTFDNLSDARRFLLLNNVSVFSFALLNLSSGVLENSDFEFEGNIASWPRALFLSSSRPSGTTAGFSIYGIISDSLKHLTSYGRFLWGIPKLVFQRHLLPRHFQLVLTSALFVHDLKSFAEQIYLHIFLAFAYPFFGATPSLLSYLRIGNISATFFWHKIIHLVLQRNSRISFLSVRTENTVLHEIELFIQQFQLSHIWQVNDCHPLELFFRDLSDFNDTLAIGVLRTCLLPYINNDVDITKLLSVDCLTEIMLSIGICRAFADYHPRAVVAIFEDADLVRSALCFCDRLNTLLGDSLVQGWCSRAFSLHQLCSDQIGIFGASLRTRWRLDWRIVNYFVGRLEQQPLDDDDIDDTSGCGRVPKLTRLACQAVRFALRLYLDGLSPPRPSFTAQIEDLKIPPVVKSIILSAVMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2X2</accession>
    <name>A0A0R3X2X2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020391">
        <property type="protein sequence ID" value="VDM32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2X2"/>
    <dbReference type="WBParaSite" id="TTAC_0000766501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000766501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000766501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275284at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000766501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27457" checksum="16625C31A266E641" modified="2016-01-20" version="1">MATRDPVIVNVDKTQAFTHAHHILSQPIFPTKKEEVLSNDIPVNRRVPNIAQSWTEGSKIVLPSLSEYSTCVVADSYARKTQERETDQGDERDKCAGLNSAQRMDQTPPFDVQLTPPRHYLPVGGIDIYTTQGPNLMREMKDRFRKKYSASYVELEPKHQPQPLLQSDRSAFPTIEKSPNAVQDLSPVPTNFSNDLSHILPSVLKERPKRAGRLPSRYASQLFPADNVCLAFKMPCRDTKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X353</accession>
    <name>A0A0R3X353_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7739</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020399">
        <property type="protein sequence ID" value="VDM32185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X353"/>
    <dbReference type="STRING" id="6205.A0A0R3X353"/>
    <dbReference type="WBParaSite" id="TTAC_0000775401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000775401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000775401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5916873at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELM2" evidence="3">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000775401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="54124" checksum="53E6BA510D9935AE" modified="2016-01-20" version="1">MPESTTSGAGGVGREKGKVEFIDLDEDTDTGDSEFEPPEGSGVQDDDSIAAEEDVADEEEVNGLMRESEMSLSELLASYGLPASAIPVETASSTMNPSNSGERSLTRKRRYNGNTAQAPTETSVAAPGGNNGTAHRPNDTKPGGVKAIEIDLTSSNGEAEEEEELVDDAVVDDEVDDDADVDEDEEDDEEEEVGSDCKNHAVSLWCQALAAGDSPPAYNSEEDEDYLPNVEGEGDWRGEMHVGEEYQASVPLTPPPANSRTDSHLGLEARMLWKPNHLSEVEVEHYQQNYSRILALAAPTTRVPDDEEVSFYISLSLLEEEIKVKSFFFSIPYTEGTLPSPSIQFRSGRGIESPSNETRPTNRFPPFRVQLRHKTVGELVHFYYLWKKTARHDEFVRLYRREKKKPLHPGITDFMDCLMKEQLSAVAGPSDEVGDLESNCQNQSQAQMTIPKTEFPSPSTQPTFPAIAVCPSDRDEAPGQYVSTLNCSSSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X387</accession>
    <name>A0A0R3X387_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7780</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020404">
        <property type="protein sequence ID" value="VDM32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X387"/>
    <dbReference type="STRING" id="6205.A0A0R3X387"/>
    <dbReference type="WBParaSite" id="TTAC_0000779501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000779501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000779501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20573at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="55"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000779501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49841" checksum="4444DC99E984FB10" modified="2016-01-20" version="1">MSLTQVIIRGAAGPSDSIDRWLMLLLRGDYHYDLDLDRSRGHVVWAIAGFLQEYVSLIDRIVEIIGVESALEFCHLTEDIENSGGLYTVDGTRRRTPCGTFLFLIRHSERVPNFEKEIIFMGPKKAVKKSETVLVSNASACLMTVGDVKDDTPRISFSFNAPPEQPVLLYTFHHFNLPTRNFNTREFCADFECQLTKRNGDLISEIKASCRDNSNPNLYGPIVTVPEATNVTCSIIWYYPEDKSLLNGSIKLMFVSAYNGDCADGPSIWNNSSSWCNVELKGLVDLEYVETHPVLCLERTVVTQVFNTTCLGYIERPPFYSPLSVIIIIICTLAFFLILLIIVLCCIRKRIARRKIRKMQKTADLRANQQRSNSNFQSGKDLRQPCEVNMNATPQNGCYFPSSNGLHKDVASEDAENADLKEAEKGETEPLNAVNINALVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3E8</accession>
    <name>A0A0R3X3E8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7855</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020413">
        <property type="protein sequence ID" value="VDM32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3E8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3E8"/>
    <dbReference type="WBParaSite" id="TTAC_0000787001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000787001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000787001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000787001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35446" checksum="84FE8D04CDB281E6" modified="2016-01-20" version="1">MSLTGLRKQINKANQFMSEKIGGAEGTKLDEEYIHCEKQIDIMSKLIEEIITKTHEYLQPNPATRAKLATLNTFNKIQGKGKAPPYPQPEGQLGECMLKYGHELDHDSLFGECLIQAGNAFKNMEDIKYNMEDQVKREYIEPLRGIQSVELKEINFHRKKLEGRRLDFDCKKRKKDSSDYKITAERMAISSVPKNPQAAKVLEDEVKAAEDKFQESKILAETAMANFLASDFEHISALAEFVDAQANYYRQASEIMDTLHKALLEKKDEAQSRGKPTHTPKPVQLTRTLSGEVSAKNGSMISPKTPIKSPNIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Q5</accession>
    <name>A0A0R3X3Q5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7977</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020427">
        <property type="protein sequence ID" value="VDM32458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Q5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Q5"/>
    <dbReference type="WBParaSite" id="TTAC_0000799201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000799201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000799201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="6">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000799201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17341" checksum="6192BC37FBB2CD6A" modified="2016-01-20" version="1">MVHYTRFVQRGRVVFISHGAFARKVAVIVDIIDQNRVLIDGPCTGVPRRPVNIKRLHLTKFVMKLPPNCGTRGVKDLWRKQKIGSLWRKSMWARKLEKKRIRAGLTDFQRFQVMVARKTRNNIISNYRMRKVTLQMIKNMRPKKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X453</accession>
    <name>A0A0R3X453_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020456">
        <property type="protein sequence ID" value="VDM32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X453"/>
    <dbReference type="WBParaSite" id="TTAC_0000817101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000817101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000817101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000817101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8895" checksum="5546EB0717DB3B55" modified="2016-01-20" version="1">MVKFDTHFVSITPAIRGVFLRLFCSFGCLSPWHKEGGGMLKVLMEKKLALHLVPLPPTVAPKPTLMFPCGSKTLATSPGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X539</accession>
    <name>A0A0R3X539_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8548</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020530">
        <property type="protein sequence ID" value="VDM33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X539"/>
    <dbReference type="STRING" id="6205.A0A0R3X539"/>
    <dbReference type="WBParaSite" id="TTAC_0000856301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000856301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000856301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="253"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000856301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37123" checksum="DD8BDE2820B1443D" modified="2016-01-20" version="1">MSSKGNTFERLPRIYEPKVYVLELYPNAKDFTFHGRVTICMFLTQPTSSIILNAKKINVISAKARHSALQSELTVPMKSIMYDEKQEKVAIHFDSELAEGDIDLCLVYKGVLADDMHGFYRSTYKDSNGEEHIILSTQFEATYARRAFPCFDEPDRKAKFRISLVIPDHLTALSCMPEVSRNPVEKCEVEKYGLPTAISHSYVKVEFDETPRMSTYIVAFIVGCFDYTEAEDVVGVRIRVYTPPNRSHLGLHALRMARSALPFYTKVFGTGYPLPKLDLVAIPDFAMGAMENWGLLTYRVVKPACACAVNPSSSLMKKCGLGYRADTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5A5</accession>
    <name>A0A0R3X5A5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS8616</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020545">
        <property type="protein sequence ID" value="VDM33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5A5"/>
    <dbReference type="STRING" id="6205.A0A0R3X5A5"/>
    <dbReference type="WBParaSite" id="TTAC_0000863101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000863101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000863101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="15">
        <location>
            <begin position="729"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="16">
        <location>
            <begin position="865"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000863101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114091" checksum="8DA5E22F3E46CB95" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X673</accession>
    <name>A0A0R3X673_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8981</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020645">
        <property type="protein sequence ID" value="VDM33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X673"/>
    <dbReference type="WBParaSite" id="TTAC_0000899601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000899601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000899601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3174329at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000899601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51947" checksum="C79388EDD1CD32FC" modified="2016-01-20" version="1">MERDCSTNLCSDNVSANCAQPLTKSCSSQDISRSAIPPPANPFSPLSNPRGADFKCEVCSKPAYLQCSFNVGHQKMDWLGIHERICSTLEWLRKPPGFYSSQEERQEKMERIKKAQTNLFEVTRNTGLKLLFNGMAEAAIPAALQCLKFSAEVFGMASVELVIPHLLLAEANIMLRRLEQAESNLAQAQWIMLKTQHECSDAIRSAIYYSSCAHGPNHIRTAGGYFQMAEVFYKLYLNERDIACEEVGKEANKETDRCPQGMINPSAAQQIPGMDGCRPMPPALVLKNPDSCDDFALSPNSSLFLSRVYKKPSVLPKPAHKDQVADDLYARVVNIWADHLSSIIVTRIKKPALSGECDPAFMELQPVVEKELDETDAAEAKKMLTSINRYRSQRAALDGAEFGTSAAGRPDPRTRLLLALSMLFWLLNDKAKAKQYYEDATVAVKKADENRKLSSELDQMKNLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6A1</accession>
    <name>A0A0R3X6A1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prenylcys_lyase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9011</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020654">
        <property type="protein sequence ID" value="VDM33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6A1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6A1"/>
    <dbReference type="WBParaSite" id="TTAC_0000902601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="133"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="56675" checksum="F41ACD7B6DF5615A" modified="2016-01-20" version="1">MRDFTQTTALTNNVPIDCHHRSSDKRVAIVGGGFSGCSTAYFLRQFLEKAVSITVFEKSDRLGGRVRSTSVEGEDELFETGGAIYTSNNKYMNMFVNQFGLVAHRHTPPDEALSLYRGRLHPCAFSSNAGPLFINRLRFAILYGTDLVRFRLAIASYRRTFDRIYDLQKKGVSFDSPVAMLGALSPVFPRMLRSTFDAWLERRLKLSDRFCKEVVYGLVSNCYCSDLTLHAFAGMTSVSGFGAELFSVVGGNEKVAQKLCEAALRSNPSDISRKVSLRTTVTKLSRGLKRRFLVTYENDGVERSEEFDFVVLAFPIHEKASAVPQADGDLIKYLPPRRKYIEVDLTHFRGELEAKEFGLPAEKLECGGSKGVTILPTYEGYEVEKSTLFKYLGRAWSTSVRNIGNSRTGMGCWSAFSLPQRTPDPGVQLLKNYAKSPAILINSSRWFAYPIFSVAQSDLEKAHGKILLTDGLIYVNSLESLASNMEMALIGGCNAALLIAHSEDFRTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6K8</accession>
    <name>A0A0R3X6K8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9130</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020688">
        <property type="protein sequence ID" value="VDM33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6K8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6K8"/>
    <dbReference type="WBParaSite" id="TTAC_0000914501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000914501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000914501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000914501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7747" checksum="675BCEACF1CF6F38" modified="2016-01-20" version="1">MIIPIRCFTCGKVVGDKWESYIVLLQAEYAEGDALDTLGLRRYCCRRMILSHVDLIEKLLNYAPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X787</accession>
    <name>A0A0R3X787_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9394</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020798">
        <property type="protein sequence ID" value="VDM34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X787"/>
    <dbReference type="STRING" id="6205.A0A0R3X787"/>
    <dbReference type="WBParaSite" id="TTAC_0000940901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000940901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000940901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241578at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="10">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000940901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31788" checksum="EA7802EFFC9F5033" modified="2016-01-20" version="1">MAGVTRVTLPVPAFNVINGGKHAGNKLPMQEFMILPVGAKSFAEALRMGAETFHHLKNIIRRKYGIDACNVGDEGGFAPNVSGAHEALDLLTEAITTANYCGKIVIGMDVAASELYENGKYNLGFKESKRDPSDNITAERLMALYNELLAKYPIVSIEDPFDQDDWEPWIVGDDLTVTNVERVQKAIDIGACNCLLLKVNQIGTFTEALAATKLARSRGWNVMVSHRSGETEDSTIADIVVGLNVGQIKTGAPCRSERLAKYNQLLRIEEELGSHAVFAGESFKHILNPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7C2</accession>
    <name>A0A0R3X7C2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9432</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020815">
        <property type="protein sequence ID" value="VDM34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7C2"/>
    <dbReference type="WBParaSite" id="TTAC_0000944701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000944701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000944701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000944701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9270" checksum="0EE1B689CF767086" modified="2016-01-20" version="1">MEVVAVVVDPTTAAMIVAMTAAVTTAVMTAVDVIVATTAALLFHVTLISLAAVLVTTTPVADISDIAAERERGGYEPREDDSLCSFSDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7L3</accession>
    <name>A0A0R3X7L3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">78 kDa glucose-regulated protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Binding-immunoglobulin protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS9523</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins. Acts as a key repressor of the unfolded protein response (UPR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020866">
        <property type="protein sequence ID" value="VDM34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7L3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7L3"/>
    <dbReference type="WBParaSite" id="TTAC_0000953801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000953801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000953801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133304" description="Endoplasmic reticulum chaperone BIP" evidence="19">
        <location>
            <begin position="21"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000953801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="651" mass="71951" checksum="1566AFE405085A08" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8L9</accession>
    <name>A0A0R3X8L9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9879</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021127">
        <property type="protein sequence ID" value="VDM34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8L9"/>
    <dbReference type="STRING" id="6205.A0A0R3X8L9"/>
    <dbReference type="WBParaSite" id="TTAC_0000989401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000989401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000989401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000989401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36112" checksum="C2E22D5986643644" modified="2016-01-20" version="1">MPRSDRQAEGYRIFIGGVDPRVGKVELEREFDRFGTIVDVWVARNPPGFAFIVYKHLEDAEKAIRRMDRSSPFGSRLRVEHAANSLKYKLEGRRRSRSRSRRRRSPSSRRRRSPPRRRSISRRRDRSDSRRYGRSSSRVRRRSWRRRSNSRSASRRSRSGRRSREDSRSVKRSRDRSGYSPRRRSVSRDRSGSNYVSRDRSASREASDRKRVRVSGSRSRSMSRRSPSRGSPDRRSRSVSRNSSRDRSGSPVNRGENGNDSRHSGSRHSSRSQSRSRSPSRRSGGRTPSRSGSNSPRREQSSDGEGSGNKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Z7</accession>
    <name>A0A0R3X8Z7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021235">
        <property type="protein sequence ID" value="VDM34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Z7"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Z7"/>
    <dbReference type="WBParaSite" id="TTAC_0001002201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001002201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001002201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10611938at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001002201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15910" checksum="4A6746AEC7DD94ED" modified="2016-01-20" version="1">MSLMLWKRLTHLHEKFVLRHASLSGIKAADVCTLADLRHCTVTPSMTSSTIGNNFCAFIISEFYPWGSFFNYMQLNSATDSLHISSDLTFVLRALIDIVNGITFLHIGKFKLFRSLVNGLGVWASLIYVQQMKTKIFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X998</accession>
    <name>A0A0R3X998_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10108</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01021318">
        <property type="protein sequence ID" value="VDM35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X998"/>
    <dbReference type="STRING" id="6205.A0A0R3X998"/>
    <dbReference type="WBParaSite" id="TTAC_0001012301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001012301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001012301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="72"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001012301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="43846" checksum="1DD992A0E6DECA1D" modified="2016-01-20" version="1">MLNALRVFRAAVSPNFSRLESFQLPENILVARNLASVSATAHLHPFKLYKLDDGPPSTTTCTREEALNFYETMQRIRRMETTLSTLYKEKKVRGFCHLYSGQEAVAVGVEAALTPGDAIITAYRCHGFVVTRGESVASVIGELMGKSNGNVAGKGGSMHMYSHEFYGGNGIVGAQVPLGAGIALHKKRNGTNNVCVTMYGDGASNQGQVFETFNMAKLWNLPCIFICENNKYGMGTSISRSSSNTAYYTRGDVIPGIWADGMEVLTVREAMRYATEWCRSGKGPIVVELETYRYFGHSMSDPGTSYRTRDEIQTVRRERDPIILFGRFMTSSGLATDDEIKAIDKKVRQEVENDVATCEKSPPPPIESAYNGVYRQYPPNFGIRGTDITQWIVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9B5</accession>
    <name>A0A0R3X9B5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THUMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10125</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021334">
        <property type="protein sequence ID" value="VDM35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9B5"/>
    <dbReference type="WBParaSite" id="TTAC_0001014001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001014001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001014001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254633at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001014001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21083" checksum="1B5B26B8FCE19A14" modified="2016-01-20" version="1">MDLLQFALGRGKEKKVQGRFSEEEEEEEEEVALGKLLYRSERCGVGEGERCMGAGEVVKNVEEEEDVARLMVKKARGASDAPQTPKRATEAIDKMVSDADDRRIGTISNRFPCHVDIYAKRLIGGFMQYRVDMEAPNVWSLVGCAKSLDSALGWHLMQQLRWACSLQLDCPRSTSAHPHPIMQTITNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9W6</accession>
    <name>A0A0R3X9W6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021556">
        <property type="protein sequence ID" value="VDM35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9W6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9W6"/>
    <dbReference type="WBParaSite" id="TTAC_0001034101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001034101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001034101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001034101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14434" checksum="76516DD29E3EA644" modified="2016-01-20" version="1">MLLKDSTPGVEPPGDVVPTCTLPCAFYSYETDRSTSTWPTKSWQLTWLNTDVGRTILEMPEMVEYRRAVEMLSQPNGDTGANKREVLRILEQNNAVERNLLAIIVVRPNFNLHKVRGRHLISSENAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Y3</accession>
    <name>A0A0R3X9Y3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10343</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021575">
        <property type="protein sequence ID" value="VDM35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Y3"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Y3"/>
    <dbReference type="WBParaSite" id="TTAC_0001036001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001036001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001036001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001036001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29762" checksum="6E87397E36312C35" modified="2016-01-20" version="1">MRSLSCGLLYFPSLSIVAQWFESRRALAVGLAICGSGVGTCLMAFCVPSGVRAFSWRGLLIIFGAVFFQLALAIALFRPVEVQQAIDLEKSRRRAEERRRRLEHERVAAVARREKLRQVTGQTQNQQKSMNSRIGGGIISRILEEKFRQRSTSTGSLDGMVITRDNELISLRTEADYQLVKTAAMAAVTAEQMDETAAGTPRHGAIEQQLHSPSQPHQRCSIVSDGPVIQPSTKVEAMNFSSVRPLSKILSSMCTMLLIYNSSMQCVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Z8</accession>
    <name>A0A0R3X9Z8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolar protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10358</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021590">
        <property type="protein sequence ID" value="VDM35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Z8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Z8"/>
    <dbReference type="WBParaSite" id="TTAC_0001037501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001037501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001037501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001037501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48083" checksum="832064E3A2D6B357" modified="2016-01-20" version="1">MPKITARKRKFDVLSSEKYCRRLVSCLFDEAFLREPQGFLAAISARINCDNPSNSKSTFAKLPDWVTNPPALVRPVPPNSHGLDGPVPFPFSITWERYTPSAETEAAVQLVAIEEPDVLVIILQNQLRSLLEHESAAHNFAAMLRSLPSRRRVSVIIFAPRWHKISIACLWPSFFYYCGAFHRSLDYLMPILLIYLLLLFLLADRFLVIRLSPTKERVFLDLLTRLQFECRLAGIQQASTVQNLAVLVGNYTKAVCQRPFKKSRLDDRHGFSFLPASATTVAGAVAAPRFPLTAACRGIGFNEGEVVRAWAHQTWLRQLATWRGMTGEVVHAVAEAFPTPRALFNAVNDVSGGSTYFVAHFKWQFPITTKKNHFLSFAFPDDNGVAKLAELPIRRGAGVLTTENRLGNAIAARIAAFFTSVDPDLLVDGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAK3</accession>
    <name>A0A0R3XAK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10563</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021866">
        <property type="protein sequence ID" value="VDM35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAK3"/>
    <dbReference type="STRING" id="6205.A0A0R3XAK3"/>
    <dbReference type="WBParaSite" id="TTAC_0001058001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001058001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001058001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78437at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="375"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001058001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="56376" checksum="57DF48F19D7F4735" modified="2016-01-20" version="1">MASAGADLICGVCTRLLSDPYSLPCGHTFCLRPCLLPHPKALAARCINCHTTFDVSQLRPNYTVATQMYRCKQEMKGEGEGVGATPPYKKEVDGNMLLSERCGACRKSVEAEALEICLHCHHSICPQCREKHRNNSMKEAMTEKNWLEKCLTKVRLLEEMVSSITPLPIMQKHLSDIFTVVGQHLSDFDLVVSDGLIPLPQLFPLCADEARRGKMINQSMFAQSTTAITKTTATSQVRLYIGGLRLSHTESQLRQHFAQYGAVTDCYIVRDCKTDESKGYAFVTFQEAAEASRALADCPHFIEGGPVCVKPSKGKKKEEREEEEEEEKEEETAAAASTSVAKALGFTSTKKGVVGKKKHKNEGSSNDSRAEVNKLRLFVGNLSPSITQQELRQHFSHYGKVTSVDVILDRESGKARGIAFVNMSTHVEVEAVLDARPHRLNGESIIVRPAHARALREAAPSNVEKADLRFVGFAPMPRTRRSMIRRGRTMYTPSCFLDSRERRQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBK1</accession>
    <name>A0A0R3XBK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10911</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022505">
        <property type="protein sequence ID" value="VDM35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBK1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBK1"/>
    <dbReference type="WBParaSite" id="TTAC_0001092801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001092801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001092801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276025at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001092801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23416" checksum="32767098820475D8" modified="2016-01-20" version="1">MKDCLLGLCLTHLFKAKGTSLEEVERNHTFFVSNVDFHRAKVSALELARGVKMTKKDANTFFVGYRQLNEEEVDRYSTENPPPRPYPHESQINVTARVRAFVSSCNHLEANSKVWSTSGCKVMRETTASVVVCECNHLTAFAGGFNALATVVSHRPSQLRGGQPQARLINGTASASPFVLVNFLLLLQRGLLRAFRMSALSVLVTALLIPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBS4</accession>
    <name>A0A0R3XBS4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022663">
        <property type="protein sequence ID" value="VDM35964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBS4"/>
    <dbReference type="WBParaSite" id="TTAC_0001100101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001100101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001100101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001100101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12062" checksum="98CCD66D3B4D3697" modified="2016-01-20" version="1">MTRRNAWTLVGPQAPPRGSTAFICVPLVVVSPLVEGRGREEQRLRWSDVAHCSAVRNTGRVKSLTMALTSHLFTMKLSALMGAVATTEDIRCDIAEVMLWRNVGEKGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC72</accession>
    <name>A0A0R3XC72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11132</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023034">
        <property type="protein sequence ID" value="VDM36112.1"/>
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        <property type="protein sequence ID" value="TTAC_0001114901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001114901"/>
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    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Protein kinase C"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001114901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41550" checksum="80CBE157E60D764D" modified="2016-01-20" version="1">MNTQERPHPARQQPPAPPPVGWNIVADSPYQNLSTDKGPENSTGGRLASEVEEAPGLPNPSQVHFGAPYTGSGKSGLTQSLQREGEFIPQRGNDLMADSGMDGGGDLHSVTSSGTEYKQATNGYFALKTFRKVDLVREHCTDCMRIEKRVLQLVTEARHPCFVHMIACFQPQDYAVIVLDYLPGGDLMQHIQSGPFDEERTVFYAACVVLALEFLHLNNIMYRDLKLENLLLTGYGYLKVVDFGLCKANMGPNDKTSTFCGTPQFVAPEMITDTGYTRAIDWWCLGVLIYEMLVGKSCDPPNCEVTHSWGRDPSQRLGVSAGGIMDIKRHSFFADLNFDALLANRIKPPFIPKLVGHFLSIPPPLPFEGTSAKQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCL6</accession>
    <name>A0A0R3XCL6_HYDTA</name>
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        <submittedName>
            <fullName evidence="3">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11277</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023468">
        <property type="protein sequence ID" value="VDM36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCL6"/>
    <dbReference type="WBParaSite" id="TTAC_0001129301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001129301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001129301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10355064at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001129301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15354" checksum="A679098BEDE20214" modified="2016-01-20" version="1">MKTVKDGFVTALPQHYRWIRVGSSSVDLGWDVDALRGLRANEMNLTAYYYTNSINYVHRAVTFSRGKLTLDRLRPSTFYEMLIQPMKNGILIRTHTANLKTLAEGELVNAHVVRKQTISSLFIVFEHTGVIRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDL6</accession>
    <name>A0A158RDL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caskin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS904</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000126">
        <property type="protein sequence ID" value="VDM17157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDL6"/>
    <dbReference type="STRING" id="6205.A0A158RDL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000090301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000090301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000090301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="414"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000090301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="602" mass="65367" checksum="129D66495FD6F4F3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDP7</accession>
    <name>A0A158RDP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphofurin acidic cluster sorting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1222</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000222">
        <property type="protein sequence ID" value="VDM17650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDP7"/>
    <dbReference type="STRING" id="6205.A0A158RDP7"/>
    <dbReference type="WBParaSite" id="TTAC_0000122101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000122101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000122101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="4">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000122101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55374" checksum="C0CFCECC587585FB" modified="2016-06-08" version="1">MHLIHTGEVFALNGKNQYQSQTVIRLCHIQIGQIILDRPIDLGENSSSGVYVALRMRGNTRRILRSPEVSLILPKHPSSSTVSATAANSGTRCVGAYIPIDLNCTIQYSHILKLDSNILQILLQKRKKYKNTTMNLGYKTLAYCNISLSQVLQRRIEHRFLSMHSNPKCVGPAIARIEVHCLSTLPWERDPINPGNKGEVESDGFLEDGCLLPADVFSDDADDDSDSDEEVDMEDVEASRCGHVGGVSSTSTATAIADRSGQKKVLKSMSVGQIKQKVISLLKRLKLADPNEDIDTGTTLHLWEEIDKIEAVSDVDEDSDLDTGGTAESGSLQSVPRPSIRPFFGHTGSSEETLSLDAGARLLRRLQKEALLTSDPMTSRQAPVLPSPASGITGPFNESSTTTETDLRRQTTTTTSGGRGGIKFPPRFGPIKTRRTVPTAKRRQVTSSPPMAGVGSTAVAPVPFKTSPFLNGHYEGGERSYGRNSDILNPPTATDLEPLEYVSLMLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDQ7</accession>
    <name>A0A158RDQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein bicaudal D homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1345</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000270">
        <property type="protein sequence ID" value="VDM17844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDQ7"/>
    <dbReference type="STRING" id="6205.A0A158RDQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000135801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000135801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000135801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="306"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="428"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="594"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000135801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="873" mass="98320" checksum="FEBE025E3E548B4A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDT0</accession>
    <name>A0A158RDT0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1512</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000351">
        <property type="protein sequence ID" value="VDM18129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDT0"/>
    <dbReference type="STRING" id="6205.A0A158RDT0"/>
    <dbReference type="WBParaSite" id="TTAC_0000152501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000152501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000152501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000152501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35182" checksum="C9F9F29CCB9FE54A" modified="2016-06-08" version="1">MDQPNRKSTPSVATVTKSLAKLYVCGLRPNHTESQLRRYFAQYGTVEECCIARNSNTDESRGFGFVTFREEAQAARALIDRHHLIEGGPVQVKPYTLKTNKKNLASTSLANDKKDENARYNDEIGVPRGRRKVDELRLFVSNLKPSATQQSLEEYFSHYGTVTAVDMIPYRKGARPRDIAFVNMATPQEVEAVLKARPHQLSGEYIVVRPAFLPASKEAADFGDDRSSRHVLVVNNVFSSWNEDRVQKLFSHFGKIINVKVNPETRKAHIAFSNAEALQYLRKQKYLNINGVHLITSTGDDGTCGATFINAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE15</accession>
    <name>A0A158RE15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcipressin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6477</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE15"/>
    <dbReference type="STRING" id="6205.A0A158RE15"/>
    <dbReference type="WBParaSite" id="TTAC_0000649201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000649201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000649201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000649201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28645" checksum="6B242228CAB5AC6F" modified="2016-06-08" version="1">MEETIDSLKSAKYASCRLIVTKVPIDVFTDIEAKNIFEQVFRTYDNSCEFIYLPSFHRVIVTMSTPEAAVMARLETQGWRLQSASVGTSNANDHEPSTESENVGIRCYFADEKEERGKCQRRQVRPAVKSASFDEDRLTDEDGDDGGTDDILDDMDTFEHLTLPKPERLFLLSPPASPPVGWEPKVEAEPLINYDLLHALAALEPGKAHELHPPERDKPGIVVTPCEGALDVRKKKKKRDLPESKIPHTACPNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REA4</accession>
    <name>A0A158REA4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6962</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REA4"/>
    <dbReference type="STRING" id="6205.A0A158REA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000697701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000697701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000697701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000697701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34366" checksum="17B1DB0A1F620119" modified="2016-06-08" version="1">MSTDLEAQRTQESASSAVASPDFEIPQGLRFLLRTTQIRVYRVPIEGENKCCSAFPRKFYVADGEGNPILEGVESSSWCARLCAESSHAFEVDFRDADGITVLSMEKTAACSTFYCCNAPAISVVSGNDNYGTVMQSGILPRTRLSLLDGLGRPQLRLLGPCARQSRYIDGIFKLKCFSERGSLGRLTVQHFAGMDSYQIYFPVDLDLRMKCLLIASAVLLRFFHAYLSIRSTQLACQFSTVRPPARLSAGEEQRFCDKNRYCRGDAAVGAARHKEGKHAYKRICALLCPLFQNVSGGGRRKGGGEAIAAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REF0</accession>
    <name>A0A158REF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7165</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020350">
        <property type="protein sequence ID" value="VDM31502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REF0"/>
    <dbReference type="WBParaSite" id="TTAC_0000718001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000718001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000718001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0401">Integrin</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043073704" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="8">
        <location>
            <begin position="369"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="11">
        <location>
            <begin position="879"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1257"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1304"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000718001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1349" mass="147410" checksum="2B5FF46BAE4333BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF24</accession>
    <name>A0A158RF24_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8643</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020554">
        <property type="protein sequence ID" value="VDM33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF24"/>
    <dbReference type="STRING" id="6205.A0A158RF24"/>
    <dbReference type="WBParaSite" id="TTAC_0000865801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000865801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000865801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043136030" description="non-specific serine/threonine protein kinase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="480"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000865801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="771" mass="83680" checksum="B1EE6DC1DB17B160" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RFA4</accession>
    <name>A0A158RFA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9336</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020766">
        <property type="protein sequence ID" value="VDM34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RFA4"/>
    <dbReference type="STRING" id="6205.A0A158RFA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000935101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000935101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000935101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000935101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="731" mass="80272" checksum="CBF6FAA6AE556947" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E3K2</accession>
    <name>A0A3P7E3K2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000106">
        <property type="protein sequence ID" value="VDM17041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E3K2"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="12">
        <location>
            <begin position="488"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119343" checksum="5F0DD4C0828A1B67" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E4U3</accession>
    <name>A0A3P7E4U3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000206">
        <property type="protein sequence ID" value="VDM17590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E4U3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="40" mass="4505" checksum="197C29E0FC5DAB7A" modified="2019-02-13" version="1">MTSEVQPSEQTIPSTEFPPHFPTGEVRIQLPVEESDYEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EAY4</accession>
    <name>A0A3P7EAY4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA splicing factor component Cdc5p/Cef1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001046">
        <property type="protein sequence ID" value="VDM19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EAY4"/>
    <dbReference type="OrthoDB" id="6273951at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA splicing factor component Cdc5p/Cef1 C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="319" mass="35834" checksum="CEDAE361D4A67320" modified="2019-02-13" version="1">MIKKEMLTMLHYDSLHNPPPTLLAELSRNADGKLLSAMAQKKRLQQVNTAHETYLRDSPYEEFSDDSLAQAAAAIEAETAVVRSAMGHGEVSGEAYARVWEECLAQVLHLPQHHRFTRANLVPKAERVSAAERRLEMLRGLMAEEAKKAARQEKRLSILLGGYQSRAQTLIKAIQESVEQIEQSQIELTSLEHLRQQEIGAVVRRTEMLKIDVERQRSRETQLQNTYAKMARLRDDRMAEAEKIYDNTTTPPLASPRAGVEGLEDETQNDPGGWTTVQQSDGELVEERNAGAQTDPVPLPEAIQIGRRSEFSVDLDAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EEY2</accession>
    <name>A0A3P7EEY2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001687">
        <property type="protein sequence ID" value="VDM21530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EEY2"/>
    <dbReference type="OrthoDB" id="10015491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="281" mass="32100" checksum="CC5574DF3505388D" modified="2019-02-13" version="1">MFVYKVRTSDQTTFSCQVTIQTFRLLQPARVKTLTSSTVFLTIYSPPERLFLRRIPLPVTSKHLQDGNINLQSDNPSLADVHTFQSFEKPLSLPRPSTHRLQHSTALTTPMEVNIQQKEEIWALEGHKIAIECIASPSSPASKLMWILSPVAEVEEDLSLQPTFDFEDFSKKSRSLQFERKYPKWRFVFDAREGAGLGFRVENKEVADSTTGLEEGERGGEEEEEEEEEEGEIKIFDDDSLRNFFLYFENTTAVKRSKTSKLEGEFKAFTMVGITLDGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EUS8</accession>
    <name>A0A3P7EUS8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007657">
        <property type="protein sequence ID" value="VDM27060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EUS8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="228" mass="25284" checksum="ED5ADBD09042769A" modified="2019-02-13" version="1" fragment="single">MRCQSGDAHPQCSSEGASLKNQPSKCPENTRTASTMTFEEESDIVLDLSQGPAVGDISKARAGYIATVVEGIESRGAIEKEKALSEAHSKQISELKAQIESLCQNAVPNKEELVEELNELRRISQQQAEQIVTLEMARKADRVEEEALNEARLKIAELKTQVEDLRKNSEVSLEAHHDEELQREATDLRLLSQRQAERIVALEKSLSASKGCEKRDTSVDATARCREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQB8</accession>
    <name>A0A3P7FQB8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01022346">
        <property type="protein sequence ID" value="VDM35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQB8"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="273" mass="31575" checksum="762FC1EAE7C74B6F" modified="2019-02-13" version="1">MVIIIPSTRARVHYFSAYFIYASVVLIGSTVYAFKFFLKGEPRYENSWLVSPIFSFLSAFSEFTKVYRLARTLMGLKPRIFGLETYDPEQQYIYIANHQSFIDVLYIWKLPSTVIAKDTLKYFGPLGAILYYTKSVLIHRSNHERAILEMNRAAEQIVNDKVSLFMFPEGTRNFSGRLLPFKKGAFHLAVQTHLPIQPVVVSCYNSFLDHKRFSFTPVPYGIYLLPPISTVGMDKSHVNELVERTYIAMSEIFDRTVHVLPEELGKDLRRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4A1</accession>
    <name>A0A3P7G4A1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="2">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000023">
        <property type="protein sequence ID" value="VDM16235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4A1"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="194" mass="21970" checksum="0FD2DC26B8955901" modified="2019-02-13" version="1">MILYVARRCFDLDPINLNVKRSAYGRPYLEGQAGFDFNVSHHGDFTLLTCCHKMRTGVDVMQMELPPAFESIAGFLLKMKSLFAPSEWHLLTSASNEDTEKIYNFFRLWCLKEAFVKNIGTGLRTDVSTVEFDLSGTTPRCSHPGVVDAEWAFEEHKLPNGHIAAVAWYEPGVLNASSATCPLYLFHLLILFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G7X0</accession>
    <name>A0A3P7G7X0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000198">
        <property type="protein sequence ID" value="VDM17555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G7X0"/>
    <dbReference type="OrthoDB" id="10373539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="120" mass="13107" checksum="2E50D4B56A1BB7E4" modified="2019-02-13" version="1">MEQDLRRNDDGRFTTDAAEVAVEVPVEPVTLSVLSADRTVGSQSNTRNRSLRKARLVSRTDEGVVPVVLVEGGVGGGFSCKRRTSARWLKRIITIWRTTNCSPSVCCVCSAHSQRSASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G7Y7</accession>
    <name>A0A3P7G7Y7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4209 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000580">
        <property type="protein sequence ID" value="VDM18622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G7Y7"/>
    <dbReference type="OrthoDB" id="49386at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4209" evidence="1">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="646" mass="73481" checksum="E037A6D36BAC2368" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GSC7</accession>
    <name>A0A3P7GSC7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005200">
        <property type="protein sequence ID" value="VDM25548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GSC7"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="296" mass="33525" checksum="CBF825C84984901B" modified="2019-02-13" version="1">MALEILSPIKGFDSGWTLALDHVNENLARQQLLLNQPREALQSLWHLLSPHSNQLEAAQSRFLQEFLNILNTVNSSGEGSREWLELGLPVFEKHHIKVMLGTPVRKTDDDCMVEARGTAFSDNENDDPEDVRTFSTHRSSLPNNFATLIFPSLTSSTDIPAWMVLTDVPFVEERQDVGVDRMKRPGEEFTRFLYSRPSYSLPRQAVFRRLKALLSLHIGRELCHDTDDGDLIVVMAQSVNGEKKKKKMQWHSIPVGGKPEYFLPGGIIRVKDCCLLDNYDAFMIVLPKSVALPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJ49</accession>
    <name>A0A3P7HJ49_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ECSIT N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020849">
        <property type="protein sequence ID" value="VDM34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJ49"/>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECSIT N-terminal" evidence="1">
        <location>
            <begin position="80"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="519" mass="58083" checksum="58B3A6EA3AE9B328" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJC9</accession>
    <name>A0A3P7HJC9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020874">
        <property type="protein sequence ID" value="VDM34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJC9"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="416" mass="44815" checksum="FA8612B5BF5833EF" modified="2019-02-13" version="1">MCDFGFARTLAGPDDRYTDYVATRWYRAPELLVGDTQYGPPVDIWAIGCVVAEMLTGSPLWPGRSDLDQLFQIINTLGRSNWALYDDQNMGIVEVVVSKLEQPIWRESLDKKFSSLQPPLEAFELDFLRACFHLDPMERATSEYLLKHKFLEGAALLTSVSIVSPLPSTTVAVSPSGDSIATNIYRVGLPAENRTKVPPVGIYARKAKIVRGSVYHPFAAWPKTELGGISNFGITGASVAGGVQQQHCATNVGLRTTGFCVNPMPAWKTVPGTQPVGGLKQNQTDGTLPSLKTNQNAYTSTQASTPFPNFQGLNCVPVFPNQSTMHSIQHGPAGNSTNTSTTTSSTAVTTSIESCCFQVAPLPITKLVATRNYLTTNSTNISRQQGLGGAAIVSLVPQSPKQGEKNVAATHLPNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HKZ5</accession>
    <name>A0A3P7HKZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021249">
        <property type="protein sequence ID" value="VDM35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HKZ5"/>
    <dbReference type="OrthoDB" id="6268303at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="55" mass="5907" checksum="D558E2A0E5FCF179" modified="2019-02-13" version="1">MSLEEAKYICKTLGQTGRLKSMAITEVNASLGSPEDATTTLHATLEIIRSALLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHT9</accession>
    <name>A0A0R3WHT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS127</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000008">
        <property type="protein sequence ID" value="VDM15905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHT9"/>
    <dbReference type="STRING" id="6205.A0A0R3WHT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000012601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000012601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000012601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273908at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="78"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000012601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26847" checksum="4A7E9475570403B5" modified="2016-01-20" version="1">MAGVRNVINDLRVQQENLQSKIEEVEAEIKNAEEENYKETLLQQKIRKTAEQEKAKLDKILKLEAQYSGLNESPESLTAKSKDAYEKQEKLLDELKEAQQQANKNDMMYEELKKRLVHMEQNRDRMEQRAALKEAEAKRLEEGFKDANSQVEVLKSKDFENDTDLMDKVSELQKKLDEAIRTAETSERVGTAFGQSIENLKQQIAKQREENEKIRKEMEKMNEVLEITEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI45</accession>
    <name>A0A0R3WI45_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G patch domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 75</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS246</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000016">
        <property type="protein sequence ID" value="VDM16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI45"/>
    <dbReference type="STRING" id="6205.A0A0R3WI45"/>
    <dbReference type="WBParaSite" id="TTAC_0000024501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000024501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000024501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000024501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34560" checksum="93A46213FA07F12D" modified="2016-01-20" version="1">MSGDDDSDEDYMSDKFLNLPVKPLCSGLTPKFVGKCSAGQRPHLPQPKYGGKQMDVRREEGLKRRIGEDNIGYRLMLKMGFKGDGGIGKKAEGRSEPLPIEIIDGRRGLGLHNIKKRRDEAIAAAREQRESELSAFQSDFRASMALRFRMERAQRQLMAARSICKTLDLARSLDQPVDKDFWPPDGNRAKLLAHSELIRREICRSGPRSSHKKKRVQQNDVGGARDSDEHGNDYDTALGIESDEEEYCDIDAAQHGPIESRPDITLSRLSNYLRESHFYCFWCGVQYSNRSNLEATCPGPMEEDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIG3</accession>
    <name>A0A0R3WIG3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS387</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000032">
        <property type="protein sequence ID" value="VDM16344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000038601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000038601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000038601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000038601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="56676" checksum="9C86DC505F0B1D7B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ38</accession>
    <name>A0A0R3WJ38_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactamase_B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000075">
        <property type="protein sequence ID" value="VDM16807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ38"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ38"/>
    <dbReference type="WBParaSite" id="TTAC_0000066401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000066401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000066401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000066401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43302" checksum="27E8A3C3B5CF2297" modified="2016-01-20" version="1">MGSRYPSLPNISVVHPYVTRVLGQNPGVMTLQGTNSYLVGPEEGSRILIDTTGGDITVIEKYVELVQSVLQNPVHHVSTPMPEPPISAILLTHWHPDHTEGISAVQDLVRRLSPPSLLDDGAPEVYKSPEGPDLKAIGYYDGPLKVLDEGMTFSPPDSPFITLKPIFTPGHSVDHMCFALSVNGTVECIFVGDLLLGRFFSISLVLAWPTTTKESFGTTIVLDLSAYMRSLEMLRQFVVKCNNPKLSFLPAHGEVITDPVGKIDEYLAIRKKHINKTRDAFLNNPEGTWLRENSLLEQIYPSAVDKMKELAVNNLRQSLFWLQAEESTKFRIAEPITAGTKEIRCESDYKKATAIARPGYLPEVLNEEWLWKWTSAEKICNNHLVNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK37</accession>
    <name>A0A0R3WK37_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">39S ribosomal protein L33, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1067</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000170">
        <property type="protein sequence ID" value="VDM17405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK37"/>
    <dbReference type="WBParaSite" id="TTAC_0000106601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000106601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000106601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000106601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7993" checksum="617E99C335160C78" modified="2016-01-20" version="1">MSTSTTQGFVKTVMVLMESVVTGHQMIGFRPRQMTTKKEMIAFDPLVQRNVLYREMKKIRSLRKAGTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK52</accession>
    <name>A0A0R3WK52_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1083</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01000176">
        <property type="protein sequence ID" value="VDM17435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK52"/>
    <dbReference type="STRING" id="6205.A0A0R3WK52"/>
    <dbReference type="WBParaSite" id="TTAC_0000108201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000108201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000108201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000108201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32542" checksum="51426D2109271AFF" modified="2016-01-20" version="1">MAKCLGDYLVVGIHSDGRIWYSSVIFLEEITRHKGPPVFTQEERFILLKAIKWVDEVVKDAPYMTQLEVLQEHNCDFCVHGNDISVTEDGSDAYEIVKKAGKYAEVSRTEGISTTDLLYRIQRATRHCDARNSIIENGSGDPEASSISTYTSGITHYMPNALRIAQFMSPGCGTGVSNSSSLEGIRAPRPGERVVYAPGAFDLMRILYVGHVQFLEKCRRLGTYLIVGLHSDKVSFFTAALEPGRIGPILNIDERFLSLLACRVSVCVCLSPILFIPAFNICIFISFFGLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKI5</accession>
    <name>A0A0R3WKI5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1227</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000224">
        <property type="protein sequence ID" value="VDM17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKI5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000122601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000122601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000122601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF5">
        <property type="entry name" value="POU DOMAIN MOTIF 3, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000122601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41310" checksum="A973E225D6D985F5" modified="2016-01-20" version="1">MWPPSLSDSSFHIPSFSPLPPPPPPPQLLPPLPLSMLLRCLSPSGVDIPLLRESNEHTPRSPTSSFNQLEQNVDFTLPFLLQQSRIYPIPNELEAKRTQRSYVAEEASISKKTKRLHRIPRSENENASNGNKKCKKISATAQNDTNEHIEDIRRFARVFKMKRLSLGLTQTQIGRALTAGDGPAYSQSAICRFEKLDITPKSAQRIKPVLERWLAELEGRRPGDQIVSQSATLGDRSGVCGSVSGSLDESGPYRADCESDESCTGIRKRKSRTNFSANALERLNHEFNINMHPSGSRISQLANQLNYDREVIRVWFCNKRQSFRNSGSHSVGGSRVTDQNTLWLPYSSPNEDEIPIDLSKKASSPTTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKR3</accession>
    <name>A0A0R3WKR3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligosaccharyltransferase complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1313</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000257">
        <property type="protein sequence ID" value="VDM17796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKR3"/>
    <dbReference type="STRING" id="6205.A0A0R3WKR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000132601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000132601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000132601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256333at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042416">
        <property type="entry name" value="OSTC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160:SF4">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000132601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20173" checksum="39702ED8FB3D7F50" modified="2016-01-20" version="1">MTLWNILWRNLRLCIARMDLVLYYTFTVLECPKLRVKKATWMHLPSRMTVFALVLSTYFLVTGGKASAILSFVGIIFDIINGPPSVGTETDARGNQKPVNQYIMEGLLCSFMFTIGAVGFILLDVVNEAKVSKLARTIMLSLGLASHTDFNAPLTRTVTGTKGSTSSQGPFLQPPAHLNPFSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKW9</accession>
    <name>A0A0R3WKW9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress-induced-phosphoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1377</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000285">
        <property type="protein sequence ID" value="VDM17892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKW9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000139001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000139001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000139001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="500"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000139001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62210" checksum="88A33A564F261FCF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKY1</accession>
    <name>A0A0R3WKY1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Seryl_tRNA_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1392</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000293">
        <property type="protein sequence ID" value="VDM17922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKY1"/>
    <dbReference type="STRING" id="6205.A0A0R3WKY1"/>
    <dbReference type="WBParaSite" id="TTAC_0000140501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000140501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000140501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000140501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47622" checksum="C552156697772308" modified="2016-01-20" version="1">MLIWQVFWRKLTTPAFKSAVLPTGSTLHRISERFTPSVEAQPDFNATALTHSVQRRGLANKFNRGFFEHVTDQTRVVRSCEEKIKRLEIQRQNLHMEFQEASKMGDGERQDRLRAASKRVKEAKNRCSQLRRTISFKVMEDLLKLPNKLRETESALPSESWFGHSSKCTVLSPGAIRTANLDNLIVYKDCGTFFTGQLATFTQEMSSLLTLLGREVKMVLGSTPRRCALSDLVRLPVAEACAWTPSLDEVIQLEHTKDDVFIPKEGGQTLINPYTRLCLVGSASLAAFVGTCHCGSLIIPIRVIEMCFTVALPQGSFFGCCLDKECPLPLRFLTLGNIYTYGKLRAVPAEELRRCEMSLWSLALVESGKPDIELASFSLLGDWVSRRAGFKTFDNSFPFMVIFRICNSPMLLLPARIGALEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL98</accession>
    <name>A0A0R3WL98_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exportin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Importin-alpha re-exporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1523</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000357">
        <property type="protein sequence ID" value="VDM18146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL98"/>
    <dbReference type="STRING" id="6205.A0A0R3WL98"/>
    <dbReference type="WBParaSite" id="TTAC_0000153601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000153601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000153601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM18146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000153601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="938" mass="104976" checksum="CBED17105DFBA43E" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK8</accession>
    <name>A0A0R3WLK8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1633</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000418">
        <property type="protein sequence ID" value="VDM18317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLK8"/>
    <dbReference type="STRING" id="6205.A0A0R3WLK8"/>
    <dbReference type="WBParaSite" id="TTAC_0000164601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46363" checksum="A806E91F31133E2C" modified="2016-01-20" version="1">MQRLRGNQMSATVSGCLFGLREFCRVPLGLWRLHKQIKNASSSSRNRGLVSNSLMQPYHDQALRREKISAAMGGKRGSPSEITASSHRSTLEHSSLAYPYVDILNLFGLIWLLNVLVVFALWLCSNAFSSIWQSAIALREFCIICMLFVVGQWFWRFLIVRCICTFGTCLVGGLTFTLTTIVSLVHIKKICDAIATVRQQRFPIGCRSGESGSKRQEYSAFRSPNETYFAVAAVPSYGVGKQLMDCVYSMVFFLIYRGQWILLTILMPPSLVKIFIHSVTLGFTYACYAFEYYARQTANVTAELLLTQVISYWPVFVGYGLPLGALDALCSVSIWSELLFAFLYPILVVGAFQVAWHKALDPKQYRVSLRLRFLAALSMKPALCTTNILIAFFASRLSCRFTPSYRGTGRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLY3</accession>
    <name>A0A0R3WLY3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MCM_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1758</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000493">
        <property type="protein sequence ID" value="VDM18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLY3"/>
    <dbReference type="STRING" id="6205.A0A0R3WLY3"/>
    <dbReference type="WBParaSite" id="TTAC_0000177101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000177101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000177101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10455063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000177101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31980" checksum="B3D873633446D1BB" modified="2016-01-20" version="1">MTKDERIVNSFALSHLSLAYRSHLLNAEESDFLDLLRKDITSMEKYMIERRNAGKGGVLHLVAEDIVAFLRLYEGLLLDNEANSIIELHRQDTFLHAFNRRCLLTEYADSEMPKVVSGRVVAVGRFTMDLTMRDVIRQINHLPVGHAFYFVVLDFDASFVSESTRNQVEYGITLSKLSGRQVNVLEAVGHDVNDKLSLDLKRTGVYFVDELSSLPDVEHQESCEEISPHIPLSQLPVRCRITPAAIYQITSMLIRQHNVAATSICLRLFSPACHHKCEYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMF7</accession>
    <name>A0A0R3WMF7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1932</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000615">
        <property type="protein sequence ID" value="VDM18672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMF7"/>
    <dbReference type="STRING" id="6205.A0A0R3WMF7"/>
    <dbReference type="WBParaSite" id="TTAC_0000194501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000194501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000194501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000194501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1132" mass="123692" checksum="C54800B04A844181" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMS9</accession>
    <name>A0A0R3WMS9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1534 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2054</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000719">
        <property type="protein sequence ID" value="VDM18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000206701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000206701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000206701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000206701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8256" checksum="4387CE94E90170AA" modified="2016-01-20" version="1">MIESRSPRGNADPSRLLGCRTPHRQRIGRLRATPTRRDTAPADFLTRSEDVAATPFSPFTSRLGYPHVQPTSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN19</accession>
    <name>A0A0R3WN19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2144</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000799">
        <property type="protein sequence ID" value="VDM19038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN19"/>
    <dbReference type="STRING" id="6205.A0A0R3WN19"/>
    <dbReference type="WBParaSite" id="TTAC_0000215701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000215701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000215701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406708at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="98"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM19038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000215701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="608" mass="67623" checksum="0A8E7C817F66E16A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN59</accession>
    <name>A0A0R3WN59_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Seipin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2184</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000831">
        <property type="protein sequence ID" value="VDM19164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN59"/>
    <dbReference type="WBParaSite" id="TTAC_0000219701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000219701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000219701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962477at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000219701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16846" checksum="AFFB6FC1AFEB396E" modified="2016-01-20" version="1">MTVRSRPRRRSTVALIKVTYIVCAVTLTTSLIVGSFLVHMLVLPYFHESEFEPGICVVAKIELHLAGRLKCENKCSKERSSFPCLRVTIVFEKDNKNRTGLLFDTIVTHQNYRNYGMEKVTPELMALNANFGRGQRMIRPTRRYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN81</accession>
    <name>A0A0R3WN81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADAM_CR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2206</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000852">
        <property type="protein sequence ID" value="VDM19239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN81"/>
    <dbReference type="STRING" id="6205.A0A0R3WN81"/>
    <dbReference type="WBParaSite" id="TTAC_0000221901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000221901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000221901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000221901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9457" checksum="FEE038CBE209C542" modified="2016-01-20" version="1">MTKPDITCENPFCRAKWEVSEWSKCSVSCGGTGYQYREQKCVWEHTGQSAGSACYDAKIEAPTAVQQCHTKPCKTCESSRTLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPD1</accession>
    <name>A0A0R3WPD1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2606</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001276">
        <property type="protein sequence ID" value="VDM20635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPD1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPD1"/>
    <dbReference type="WBParaSite" id="TTAC_0000262101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000262101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000262101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275873at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000262101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25964" checksum="71CB489A148E1F91" modified="2016-01-20" version="1">MSSAERHFVGDLDTMDVCRGIGSRQDSGFSDIIARSSTIGEVSDTSLQDSLLQSSPIGFRSPIPRSPNQQEVSRLWRPLHRLPDLQQFASRGAMPINPNRSFRPRSAPLAIDRFSLPEEDEDQDREQTDDEATDHEHHHHQQHHHHHHHQQLINHRDHSPPPPVVFIPRDRRRAGGTRLHNTLIGLIFFITRHDHLQGFCHNHIMCCGTFSSSNNVVDQIHSPFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPG1</accession>
    <name>A0A0R3WPG1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2636</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the XK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001310">
        <property type="protein sequence ID" value="VDM20740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPG1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPG1"/>
    <dbReference type="WBParaSite" id="TTAC_0000265101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000265101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000265101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000265101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34064" checksum="7994918F43D7A856" modified="2016-01-20" version="1">SGVVTSVLFYRRWRSAETQTRSKVDEANHEAWICTRAALSLIGMAPIARYVELLAIYRRLSRLERRQGTEDKPPPKVRQFQYRDVAPMNPREPVVSSAASVELENLRRLRRLFVQFDFDACVVALANASIGAGPFAIAQGVLYFRRLLLNRMMPTSTSGAILGAFIFSIIWLTSAACQFQPDAHYLPCSELLRSPAHRHQHLVSASGRILLFFARFVHITIRLITFTLFAGLFDWLLAVVVAVHQVVYLVTLLIYRGSKGVLSSAYKAHPNYKRPLDQRLKVSERFISLTPLSLAAKVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ21</accession>
    <name>A0A0R3WQ21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">H/ACA ribonucleoprotein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001583">
        <property type="protein sequence ID" value="VDM21319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ21"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ21"/>
    <dbReference type="WBParaSite" id="TTAC_0000286101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000286101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000286101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000286101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17091" checksum="4CD3B37079165A40" modified="2016-01-20" version="1">MDQPLPQRPGPSKPSMMASSSSVSASTRLRLAPDTVLQARVMSGDYEAARLVGLLPTKVAGEHVALVTYLESEEQEEVPISMLRTMDNAEVTADMLPVVYTSTPSRAEALSSGGGGGGGGGGGGVIRGGRGGRRGAPPTRFRGGGRGRGSITHRNPRGRGFYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ91</accession>
    <name>A0A0R3WQ91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2916</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001671">
        <property type="protein sequence ID" value="VDM21504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ91"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ91"/>
    <dbReference type="WBParaSite" id="TTAC_0000293101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000293101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000293101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261825at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000293101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49440" checksum="411D380EC3401D2F" modified="2016-01-20" version="1">MAIESNEKASLYRMIPNTQMPGKIVFVDNNFEKQNITEGPVSEALALSPIGSGKRAATSMQNYNLRRGLSASAAVLTNLESVYITGPGGPEDPLGAAEYPEVVTRSAFNYPHTVSRDGLQGTEFSPAVFRTLMGTKGTAQAVNIGQHGEYDAATFQRRCTSLKPTSGIVTTANPYHYIHPPYVYTPIVGSPSSQVVQCRGISEPNNTDTSPYSPHSVQHRQPYIFANERHTYHDLDILAATLQRQRRPPEKFVEIAPPGVSSPSYGRLRQPISSYAIASPNKRYVAINTRMAPDGEVTSLMEPMTTIKRVRIPIAPTVQIDSTGEGEGGRTSDEGASEAFDQQSSPNSLSEAFTEAEFEGGLVGEEEEPESITDPNAKLIIYEGEQTLTLKKMRAEGKQLQTPPHHQPESESQATEEIVVSSEPGFPPSTTESVQQPLPSQMPLTYTVHEASFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQQ8</accession>
    <name>A0A0R3WQQ8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3083</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001901">
        <property type="protein sequence ID" value="VDM21924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WQQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000309801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000309801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000309801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM21924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000309801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46723" checksum="954F25125941CA84" modified="2016-01-20" version="1">MEEIGLSPNLHEQGEVDVPDFAPITPIDPLRLNDEDLYQKLKSLKKQLEFIQVQEDYIKDEQKNLKKEYMHAQEEVKRIKSVPLVIGQFLEAVDQSTGIVGSTTGSNYYVRILSTIDRELLKPSASVALHKHSNALVDVLPPEADSSITMLQADEKPDVSYADIGGMDLQKQEVREAVELPLTHFDLYKQIGIDPPRGVLMFGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQAVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINAICQEAGMQAVRENRYVVLAKDFEKGYKNNIKKGNQELDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQT6</accession>
    <name>A0A0R3WQT6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3110</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001939">
        <property type="protein sequence ID" value="VDM21969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQT6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQT6"/>
    <dbReference type="WBParaSite" id="TTAC_0000312601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000312601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000312601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098560">
        <property type="term" value="C:cytoplasmic side of late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF46">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000312601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9045" checksum="1CC461F4256F7E76" modified="2016-01-20" version="1">APVVSEPVIHHRTPTLTKCPNCEAEVVSNVEYRNGLCVWLSCAGCAAIGGILGCCLIPFYVKSFKDVDHSCPNCCYRLGVCKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQV2</accession>
    <name>A0A0R3WQV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XK-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3127</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001960">
        <property type="protein sequence ID" value="VDM22006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQV2"/>
    <dbReference type="STRING" id="6205.A0A0R3WQV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000314201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000314201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000314201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000314201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20260" checksum="5ACFE93C2E437D0F" modified="2016-01-20" version="1">MMDSWLCKRRFQCVGFFCILALMTESLTSIVHGFNFYKEIKGQAFLLSLLTCALVADIVCIKAFYDEQSRKYVVSMGLVKEEGSCFFNIYAAQRLNDLPEQCICLSELVHFPVQVVYTYFMSPTTRALQWAFLLSTSGSLPPPLDLNEKSSTAAPVQVYTRLVDAALCKVGSVLLYLTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRC2</accession>
    <name>A0A0R3WRC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ephrin-A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3297</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002203">
        <property type="protein sequence ID" value="VDM22342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRC2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000331201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000331201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000331201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6312362at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000331201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8251" checksum="095A850087A9339C" modified="2016-01-20" version="1">MGVHVGYGTESRTPPGEYGCFIPESPKDIYAHLDLAYPRKSHQTPPAPGVGSITQPPLLPPQLLQVCFSSSAYLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRY6</accession>
    <name>A0A0R3WRY6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GC-rich sequence DNA-binding factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002560">
        <property type="protein sequence ID" value="VDM22775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRY6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRY6"/>
    <dbReference type="WBParaSite" id="TTAC_0000352601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000352601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000352601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000352601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31639" checksum="A4C77B0DB4B95ED5" modified="2016-01-20" version="1">MFRKPRRAYRVQRKEESDGEAEESPTDVAQTSETNPSAPIRSSGTKHSAKVDGFSVSPNITHEDETIKVRPLNRASSEQFSSMLKQGVIPDASTIHMVRKQRQQAKFQLEAEEENFSSPHPSSNDGRRLIREEDDDEEDDFEGSGANVYHHRRPAFTLSAEYRDPKSRRRVEISRGLQRRHEREQEDDKERRSMLEAIENASKNKHEEGDDDVDDDEADDTWERQQIQKAVSSKNTAVLEALEPLPSTDGGLLPKPSRRLADFGDVTLASIKSTLQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSB2</accession>
    <name>A0A0R3WSB2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme O synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3637</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002784">
        <property type="protein sequence ID" value="VDM23040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSB2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000365201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000365201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000365201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM23040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000365201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="35341" checksum="E5A5E3D654573829" modified="2016-01-20" version="1">MDLSLTKSFSFNTFPLSSSHQARTEALSPVSRSERGSVGLVNLVGVWAALSKARLTGLVVSTALAGCALAAPSPLVCEAFLAHPATSILALGVGTLLTSASANSINQVDTATIGVAETLFHYTEVSPMGANLFASTTATLGLSVLYVGTNGLVASLAAGNLLLYTCVYTPLKRVSQVNTWVGSLVGAIPPLMGWAVATGSLNSGSMVLACLLYAWQFPHFMSLSWLTRREYANAGYVMTANVAPQRARATALRHSLLASLICFLGAGGAGASQVNWCGGLAAAPFNAMLVYYAARFYSTPLENAGAVCSAARSLFRASLLHLPAVMAALLICSHCGLTSGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT45</accession>
    <name>A0A0R3WT45_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003293">
        <property type="protein sequence ID" value="VDM23767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT45"/>
    <dbReference type="WBParaSite" id="TTAC_0000393501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000393501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000393501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133028" evidence="2">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000393501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10163" checksum="EDD58226B1D74B42" modified="2016-01-20" version="1">MSLFVFFHSLFSYTVTEEKDSNICSADLKLSVRSSGALDCQQKWDPEHQNTVTLSGRVRAVQAMNQDQGFGDEHTHDRNAMMPVRLSQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTF0</accession>
    <name>A0A0R3WTF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4025</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003506">
        <property type="protein sequence ID" value="VDM24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTF0"/>
    <dbReference type="STRING" id="6205.A0A0R3WTF0"/>
    <dbReference type="WBParaSite" id="TTAC_0000404001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000404001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000404001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000404001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23627" checksum="492195A2FABFF203" modified="2016-01-20" version="1">MDHNHITKIPFGIFSRASNLAKLNMKNNQLAALPPVAAMVMVSELVSFMCYHMCTGGEWSGDENCFADVKTWTSLVELNLGTNQLTKLPEDIDHLVNLEVLILSNNMLKRVPPSIQELRKLRVLDLEGNHLDCLPTEIVSHGGGWSRKLQVGDQVHVVIYRVSVSTSSTVNQRRREQHFDHGFVVVYPMLEVNCLYYTFRRRCEECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTF1</accession>
    <name>A0A0R3WTF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATE_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4027</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003515">
        <property type="protein sequence ID" value="VDM24013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000404101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000404101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000404101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10588677at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000404101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13789" checksum="88D2CE23146E2EB2" modified="2016-01-20" version="1">MPSPPSIPRLPHNLLSIYIGLCALIEEDHARSAPIISPFECTKEAAFRALSRPSAHDAAAETAGALQFASYHQQCCLHEHTLIAVGVLDLVPGCLSSVYFFHPSPPDYAFLSLDFTSYFVMPACVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTG4</accession>
    <name>A0A0R3WTG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4039</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003537">
        <property type="protein sequence ID" value="VDM24034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTG4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000405401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000405401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000405401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000405401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9363" checksum="CFCC2CF00AE19863" modified="2016-01-20" version="1">MDALFCKELSFNRFILVSGKSEICKLPIAPGNCKDRFVSWGYDASKGHCVRFVYTGCGGNDNRFRTNGICKRVCVDHSTKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTY4</accession>
    <name>A0A0R3WTY4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4209</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003916">
        <property type="protein sequence ID" value="VDM24428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTY4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000422401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000422401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000422401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288788at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-box" evidence="3">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000422401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25034" checksum="B95ADDCAAF4BBB11" modified="2016-01-20" version="1">MPSLLTPMSAAAITVNQQHQSSSNMLPQWRNHFEGSTTPPTQQSGATTASLGKLETSSLSSSTHSSGTVSPHIHAANGQSHPVVPNMDALGIFRGLQDRAIVVDQMHYATALAATLAAVASNGLPKSIPPSALPNGMHLSGDYTTRSSRDLQTRGTLGALPSASGLHQQPPPQPPPPTYFRMNTELNAFMKRVQEEEAEIKKHDCPKAELAEPELWRAFHKMTTEMVITKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU06</accession>
    <name>A0A0R3WU06_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4231</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003970">
        <property type="protein sequence ID" value="VDM24484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU06"/>
    <dbReference type="STRING" id="6205.A0A0R3WU06"/>
    <dbReference type="WBParaSite" id="TTAC_0000424601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000424601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000424601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000424601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10958" checksum="0E40BF2F3861464D" modified="2016-01-20" version="1">MTRGISGGERKRTNIGIELITDPSVIFLDEPTTGLDTHTASKLMKLLKRLTADGKTIIASIHQPNSSIYKLFDSLTLLCNGRAIYHGPVADDAPLNYFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUG7</accession>
    <name>A0A0R3WUG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PRRT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4393</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004306">
        <property type="protein sequence ID" value="VDM24828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUG7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000440701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000440701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000440701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000440701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32129" checksum="415997F03F54F75B" modified="2016-01-20" version="1">MELQPNTDDLEDIPESQSPEGMDLKAHSMELDDEPEVEEPSEMSLDVNSKSEGLMPPDEGLISEYCPGAGDLNTGNTGASDQNCGVSELVCSLFGTQKEFVKPDTGIGEGLQGETENQHLTTNASGKAVDQSPMGPPSTDTRRPLSEPSIQRQQGPRPTSDQRTTLNEKLHQQPLQQAEIFEAPTEPPSTSEVEAEATENGAVQHVADEAAAKAAPLIAFDSATDTQQEEGRDVGMRENNNDQAETGTDPERQLPMSLENFDSAVIEVKRLGIQKLVLYIFGVYLTVFVPEFFSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUU0</accession>
    <name>A0A0R3WUU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4513</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004642">
        <property type="protein sequence ID" value="VDM25090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000453001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000453001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000453001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000453001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8307" checksum="63C3170171803D51" modified="2016-01-20" version="1">MLVGNKIDLIVRSPYFESNRKVLTPDGGFTLDSSDRGTSSPGGICEMDKPIKILLIGDSAVGKTRFVVLNVPDNQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV46</accession>
    <name>A0A0R3WV46_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4620</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004904">
        <property type="protein sequence ID" value="VDM25302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV46"/>
    <dbReference type="STRING" id="6205.A0A0R3WV46"/>
    <dbReference type="WBParaSite" id="TTAC_0000463601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000463601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000463601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM25302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000463601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32829" checksum="B24AE8AA16299998" modified="2016-01-20" version="1">MSKFKELIECTVVDEVSKTEGIVTYEQYVGDNGFVIKQGDCVFVPSTGNSSDRQILRIDKIWRNVNEEGVSMTGSIFVFPAEVEHLPTRVFYPREVFLTNNDRTTFSITSVKGKCVVMRPADFCIARPTSYREGDVFVCESKYFEDEKAIRKLKKGLKKHKFSSDTVSDEYFLFSQPIVPHKEASPLLVKASPSPLILDQLNQPPSLAVACVVAAANGHTTPVADFGPRLAPAPPQSPDVGQLAFMEVGLDRSGKKVNHSCVNLEPSKNFPFHLCSLSLVPSNSAINSFNNYSVSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV53</accession>
    <name>A0A0R3WV53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4628</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004923">
        <property type="protein sequence ID" value="VDM25319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV53"/>
    <dbReference type="STRING" id="6205.A0A0R3WV53"/>
    <dbReference type="WBParaSite" id="TTAC_0000464301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000464301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000464301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000464301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15908" checksum="78B70A694D249842" modified="2016-01-20" version="1">MNFLGIGHSGAIDITLNNLTNRKLVEVKSDQQQTCFLPVFYNGESISGQVTISLKRGSKLEYQGIKIELIGYIDFYSDRGSRDEFLNRTQELARPGILSQSSTTYPFLFENVELPFESYSGSNVHLRFVEDIMFVLIVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVC1</accession>
    <name>A0A0R3WVC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4139 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005116">
        <property type="protein sequence ID" value="VDM25468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000471101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000471101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000471101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000471101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17303" checksum="3A979F9B57E02A58" modified="2016-01-20" version="1">MPEYECTTFDPYCLKDRPLRIDHLHIELPSVLKKRLVLGELDSSVIKRGTVNVELLEHYAYDTRTKRHISVKNSLKLAVKASDRRTVELLLVRPIEPPADIFVSVRLSEMIGQRSKVRSNTRFYLYATENNTLNSTSISNDIDEWRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVU6</accession>
    <name>A0A0R3WVU6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4871</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005549">
        <property type="protein sequence ID" value="VDM25794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVU6"/>
    <dbReference type="STRING" id="6205.A0A0R3WVU6"/>
    <dbReference type="WBParaSite" id="TTAC_0000488601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000488601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000488601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000488601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9079" checksum="25B64B2AA268BE32" modified="2016-01-20" version="1">MGDGSYAAIPSSRGPVVNRVSGRSGVDSGNLLYSSYNGGSSLRASDDRFGGGGAIEDGDDVDDDDLAMLRSANVGLLIVVVLEPFVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW47</accession>
    <name>A0A0R3WW47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4972</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005813">
        <property type="protein sequence ID" value="VDM25970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW47"/>
    <dbReference type="WBParaSite" id="TTAC_0000498701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000498701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000498701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000498701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12682" checksum="F690323445A44624" modified="2016-01-20" version="1">ECSYCTDAACASPSHYTQYTLTVIDIYCRAEMSNEECNALTVDVEVLLVCDDSNWDNVKVAQRQNAVLLPHGCGIVELARPTSTTGIIYVHHAHHCEALDGTEHAPDIFDDGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWJ7</accession>
    <name>A0A0R3WWJ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5123</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006314">
        <property type="protein sequence ID" value="VDM26313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWJ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWJ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000513701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000513701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000513701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000513701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23676" checksum="1481757656507AB4" modified="2016-01-20" version="1">MAITFTEKVAKLCCINALIQSYVSSQHDPTLKAPEFILKMMKKELAYNKSLDDFEWVYLKLCGNNSLETEYRLQDNDIILHKLPTKFFLLKKDQCLKELNLTGNNIMKHGAQEIGESLKVNRTLERLKLTGNPIGREGGIGLAHGLLLNNTITQLDVGECDLEISSAIAFATVLRTNKTIDYFSMDRLILFTRQEEQTVHIYEMLCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX23</accession>
    <name>A0A0R3WX23_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS5299</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006941">
        <property type="protein sequence ID" value="VDM26650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX23"/>
    <dbReference type="STRING" id="6205.A0A0R3WX23"/>
    <dbReference type="WBParaSite" id="TTAC_0000531301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000531301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000531301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20033">
        <property type="entry name" value="FH_FOXP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM26650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000531301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19782" checksum="9DFEC08368C2A2C9" modified="2016-01-20" version="1">MKIGTPHIRDTDHFSTNSNPDNGIGAGSPIVKVEDSSSVNDSTPPPPPSQPSSTTSVVPTSTQSKRESQSLTEECSLSQRHFYRTQCIRPRFTYASLIRQAICESPNKCLSLSEIYAWLQKEFLYFRQNEATWKNAIRHNLSLHKCFRRVETAGGSVWVFDEHECLQRKDGKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXJ4</accession>
    <name>A0A0R3WXJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007653">
        <property type="protein sequence ID" value="VDM27058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000548401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000548401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000548401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000548401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="43" mass="4720" checksum="1CEB4D2596800875" modified="2016-01-20" version="1">MCRFSLLKDNRVVVDKMPEYKLVVVGAGGVGKSALTIQLIQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXM0</accession>
    <name>A0A0R3WXM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007726">
        <property type="protein sequence ID" value="VDM27090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WXM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000551001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000551001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000551001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000551001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7251" checksum="DB51D4DC9D57C338" modified="2016-01-20" version="1">MDYIFCSGASLHPRQVLMPPCRATLGVAPNSDQMQSRICSATPSATAHETTFSLASKVGIVAVSATSPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYZ4</accession>
    <name>A0A0R3WYZ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4455 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5969</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010009">
        <property type="protein sequence ID" value="VDM28082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYZ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYZ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000598401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000598401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000598401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000598401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14117" checksum="6C1DF916FFEEC978" modified="2016-01-20" version="1">MCHFSPSPIPFLKLTQVLDFEPYAVLLMSLFSEYFKLQSQYLESRLKELLKAAEVLSQEDKKIVLKVQKLWLDSKRNLSWEVEQFNQLATLLKDAEAAFSKYEVIISEQCLNFSILMGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ97</accession>
    <name>A0A0R3WZ97_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRP2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6088</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May act as an adapter that regulates LRP2 function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ97"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ97"/>
    <dbReference type="WBParaSite" id="TTAC_0000610301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000610301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000610301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052323">
        <property type="entry name" value="LRP2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44554">
        <property type="entry name" value="LRP2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44554:SF1">
        <property type="entry name" value="LRP2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000610301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38596" checksum="1C4A4AD0D097E0DA" modified="2016-01-20" version="1">MSCLRSCELEPTPNPTRKEREEAPIFMIRLETGDVVFPPVNLYADFVDSCKKYKVIGEEGKLTRYIVSENLEYVLQKRVDERDKNRNDDSFQLGQVLFEKGLYSQALVYFKNSILMYDDPRAKYQIGVMLFDDLLDGEDIKQHLQMAATYGDTKVSVMAQTTMGYFYSSADHMDLSKAFYWHSEACQNGSVESQAVLGVLHMFGLGSASKDWSIALNCLRDASERGSVYATGMLSFLYFRRALYTLASRTAYSLVGNVGLCNNIMVDTRDGGGGSGHGVFDIQTRCFIQRGLAVACFIYATCLDRGLGIQQDRGIANTMYSRCVNIDPTTTSRLQNMVIREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0T0</accession>
    <name>A0A0R3X0T0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6748</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020320">
        <property type="protein sequence ID" value="VDM31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0T0"/>
    <dbReference type="STRING" id="6205.A0A0R3X0T0"/>
    <dbReference type="WBParaSite" id="TTAC_0000676301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000676301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000676301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000676301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12153" checksum="5193FA324C1BF827" modified="2016-01-20" version="1">MSLQNLQTHDPFADDGESNKGDTAVHIRIQQRNGRKTLTTVQGIPDKFDKKRILKVCKKDFACNGNVVQHEQYGEVLQLQGDQRDNIADFLKKYGLVKADQIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0V3</accession>
    <name>A0A0R3X0V3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase_M14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6774</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020322">
        <property type="protein sequence ID" value="VDM31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0V3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000678901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000678901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000678901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF12">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="172"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000678901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1223" mass="136733" checksum="10A325EF7B944F5B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X198</accession>
    <name>A0A0R3X198_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6946</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X198"/>
    <dbReference type="STRING" id="6205.A0A0R3X198"/>
    <dbReference type="WBParaSite" id="TTAC_0000696101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000696101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000696101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000696101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23819" checksum="14DAECE0EBB9B2CC" modified="2016-01-20" version="1">MREVEVFRLKLVMQSQQLSNAIDLKGSIEVVAEYFNVAINNILYIRGIYPEASFKQVKKFGRSVLITTDEELSDYLSCLISQIKVWMSSGSLKRLVLVIKSVKTDEVFERWQFNVVKEEESSSVPKNVDHVNSELSAIIRQIVSSSTFLPVLSSSCTFNLLVYVDKNTEVPDDWGETGPCFVPNSMHVQLRSFSTRIHKVESVVSYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1E4</accession>
    <name>A0A0R3X1E4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Four and a half LIM domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7003</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1E4"/>
    <dbReference type="STRING" id="6205.A0A0R3X1E4"/>
    <dbReference type="WBParaSite" id="TTAC_0000701801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09343">
        <property type="entry name" value="LIM1_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09341">
        <property type="entry name" value="LIM2_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09347">
        <property type="entry name" value="LIM4_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09425">
        <property type="entry name" value="LIM4_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09430">
        <property type="entry name" value="LIM5_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000070">
        <property type="entry name" value="Four and a half LIM domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000066">
        <property type="entry name" value="Four and a half LIM domains protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000081">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056807">
        <property type="entry name" value="LIM_FHL1/2/3/5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25076">
        <property type="entry name" value="LIM_FHL2-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="313"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="435"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="495"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="552" mass="62538" checksum="15B8F59009AC1360" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1J1</accession>
    <name>A0A0R3X1J1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020342">
        <property type="protein sequence ID" value="VDM31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1J1"/>
    <dbReference type="WBParaSite" id="TTAC_0000707701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000707701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000707701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251918at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000707701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22578" checksum="CDD7995122026902" modified="2016-01-20" version="1">MLKPSKSHLVDRIGSSFSRMDEVYACICERSASLASVRRQKCRVEKHLGFMMPISIEVQLSPYIDARVLANVALSLGTSVARDLEEIFDSLVLLRTLALKVFDFCESLTNLLKEMLAKESCYLVAFNNVVEILMELAENMVDEIDLLFQWAYSIVLPEFGVAAVSPSFDFASSILSGKMLSASLWREEICPMLKFVNISGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1K5</accession>
    <name>A0A0R3X1K5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7083</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020344">
        <property type="protein sequence ID" value="VDM31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1K5"/>
    <dbReference type="STRING" id="6205.A0A0R3X1K5"/>
    <dbReference type="WBParaSite" id="TTAC_0000709801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000709801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000709801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000709801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16358" checksum="EB1D3C062A24FC65" modified="2016-01-20" version="1">MYCVEQWPSPLQRLIYSVLVVIGQFLTPLIVTLILYAHIGWWLAHRRGQLYHTQKTSAGHIHLAARLEVRTRRTHRILVGIVACFAGCWTPWTLYSLYLECTVFAIADVPVEEMAMVDPGNQNITVNANLKTTDLVLKASLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X209</accession>
    <name>A0A0R3X209_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7273</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X209"/>
    <dbReference type="STRING" id="6205.A0A0R3X209"/>
    <dbReference type="WBParaSite" id="TTAC_0000728801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000728801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000728801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60433at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000728801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38129" checksum="34C18E873238B110" modified="2016-01-20" version="1">MDYTGRFPRDLISTPEMKEDLEGKVREAFVDVRPIGGHTKAIICESRVMGTFHFFLVEVFKKPHKTSFNSRKPHIQLGNGEETLNKTSKSRSIKMDVYTRLLLSTLYHDQEYINTLVRRLRYATFVYPSDLLNDTTCEIVSSRHGWRSTSQKRGSVFVGGSGEGERKFAVFKVPHLPHPPRNMSAGTLMAGGLWKRNTLEAGEKGRRWRREQKASQKMARKNSVSTLSVFSGREKSGSMSAFERHSFVGIEHLTARMDVATTRKRGAAGEEDGRISRHPSNVSECVTKSSSDDDVVFDSVSSSPSLGGTGGGGVRRTSSLSSLVACTEDLFSQYFPSSSSPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X234</accession>
    <name>A0A0R3X234_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020361">
        <property type="protein sequence ID" value="VDM31669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X234"/>
    <dbReference type="STRING" id="6205.A0A0R3X234"/>
    <dbReference type="WBParaSite" id="TTAC_0000732301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000732301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000732301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000732301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47352" checksum="D7B5C1BDE50F1EF7" modified="2016-01-20" version="1">MGNLGSAVDALGNGSPLPTNVKRYKHKSEVQSYRCCRFSPSETSKPLIEGPQYAINGLQLGTGSEGRKNVRFSEQIGCVQISCIDLREGLVERISGRLKSFCNPRSSTVIFASEPSAHLPSLLCLPKCNRRRQSIGSIEVAVWNSGRQLRQTIASPTPFRRFADFPSNLLRGHEVLSFDKWRSQPSLESHVHKNKMGMELPLNSHFDRMESVYLSDLDEDYEWGSTPSEWEGYEIPLSILAQKANMKQVKPWELTSNYSSDEDYEFDEYMTPKTDLLHILKANKCTQCKVIKESPERTESSDEKLTSSAVTLRRTALQDRVANSLNRLNLPEWMKNKPKGMVEAKHIKSSVRLPRFPRHHNAIHGSRRLIVQDCSRNVNVGGIGYACGSNCIHSPLSAGNMSAKRAVTIETLSMKIRELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X340</accession>
    <name>A0A0R3X340_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane BAX inhibitor motif-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7725</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020398">
        <property type="protein sequence ID" value="VDM32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X340"/>
    <dbReference type="STRING" id="6205.A0A0R3X340"/>
    <dbReference type="WBParaSite" id="TTAC_0000774001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000774001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000774001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000774001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32010" checksum="8776348FDF0C7A06" modified="2016-01-20" version="1">MNFRNFLVCVLAKQKLGRAVVISIGSLFGEFSSNGMSGFSLGQKLESEFEYNNCVKDADIYIRMGKSTLVLKRKRIPPETVFYPFCSVDPNLHYGSYPTFFQGTFITFLGRKVRYFVILTQYSPFALFSLMVLSFALLISMFYKRYESPINFILLFSFVFVHFDLAIILQAFLITAFLTVGLTLYTLQTKRDFSPWSACLGALLMALLVGGISNMFFASSTIHLGLSICGAFLFACLLIFDTQMIMRRFSAEEYIAASITLYLDILNLFIYVLRVLQAAKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3B8</accession>
    <name>A0A0R3X3B8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7820</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020409">
        <property type="protein sequence ID" value="VDM32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3B8"/>
    <dbReference type="WBParaSite" id="TTAC_0000783501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000783501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000783501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000783501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="8207" checksum="8836A7CCF4175BF6" modified="2016-01-20" version="1">EEEEEDEEEEEDEEDREEEEENEEDEEEEEEEEEEERCNEEKQRHFRSCVKTTFPEEEDAHQNPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3J3</accession>
    <name>A0A0R3X3J3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7907</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020420">
        <property type="protein sequence ID" value="VDM32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3J3"/>
    <dbReference type="STRING" id="6205.A0A0R3X3J3"/>
    <dbReference type="WBParaSite" id="TTAC_0000792201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000792201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000792201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000792201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="46650" checksum="F01C13269983F614" modified="2016-01-20" version="1">MYRIISKGRSFLRNIATIGGRHEKSDKNTRRSFFSFVTSVSGFDNKHTQFETQRRPLRAYGDDAYFISITDASCVLGVADGVGGWRSYGVDPGEFSMTFMSTCQRLAQSGRFKPSEPMLLVTESYHEVLDAKTPILGSATFCVISLCRSDGRLHTVCLGDSGYLVIRHGIVVKRSANQKHTLNTPFQVACLPPNEHGQFYRDSPEQAIQDSFGLEPSDLVVVGTDGLFDNLTDQMILQELAPLQNCDLSLASDELLDWCAYRLVSCARDAADNPNFLSPFANEARQYGLNIAGTSQHMMNISSSRALFLWPELLIIQNLFLFMFLLPPCIRFFYYMSSLSNGRSDHVRCFNVIAILGGVRGDITVMLALVVNEDAVSDVHSSISPTSIYGSVKKTVFRISRGRSSSPPSALAITRDSSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X448</accession>
    <name>A0A0R3X448_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ESCRT-II complex subunit VPS36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020455">
        <property type="protein sequence ID" value="VDM32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X448"/>
    <dbReference type="WBParaSite" id="TTAC_0000816601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000816601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000816601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000816601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="42445" checksum="87171DF5D818906F" modified="2016-01-20" version="1">MGDLLIYSHSISSFQKGFGDAAVANQILLSLQPCDRNYYIPSPTSYSIDHCLIFYSRAAGLHTLTTPFGSLPCLRVKTLADTPEFSTKITRTRLFLGPNASLILSISLRDVPLNASLHLETMFPRMSSTVTSNSTKQCLFVVIPTPQSFGDIHLQISIADWAIYLPISIDLESVQSVDEVDGEDLDQVLSITHPWKFTSKLGGNETELEDRLSRLLQCAITLGKWIIVNRGLFAGCRVRLSRSAAKSLEFEAMTCRIELHHLLSDYLYRNGLVTTEKESRGEEVGRGTVTLDDLRDALLIELGLFKSAICAPLIRRALISRVPLVTSSTVISPSISALKVADLVADWRAAAEGSQPIDQSMAADVLGGSLKVLAGACSTTDSIITKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4S8</accession>
    <name>A0A0R3X4S8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8416</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020501">
        <property type="protein sequence ID" value="VDM32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4S8"/>
    <dbReference type="STRING" id="6205.A0A0R3X4S8"/>
    <dbReference type="WBParaSite" id="TTAC_0000843101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000843101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000843101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000843101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="501" mass="54286" checksum="12C58A34ED124B9A" modified="2016-01-20" version="1">MQTYIEVTGSDTEQLGTCLSMRELGMFFGSLMGAFLADRFVKRRHFVVAGSLILGATTIGAVPWCRTVASLSATFFFSGYAHGAMTAILSMVQGESANFRPPLEVIADKVQSLLRSRLITLYYIGTLIFNFTVVLNFTALANTGGNPLLNSIWLEKSGGPFNFMHSGYGVGAAVAPGLLAPFTFAMEKTLANGTVVQNKIISLTVPYFIVGGLCCVCACLFCCFSLCKSAKEDLNCGVDDFVLLLRRFFRLLTMMIFIKETSESTTAKSEDSDSSEEFKDTKAEAKKSALLQALAAQQRVLLYIIVPLFLLYAALVGNERVFSKYLFVFANEGPAHLPESDCFLLNSVYWIVFALARVITVPVSLVVPLPILFAIQLIGAWAMALGLYLAPANRTIYLAFTACFGLFKSPLFPTGLGVVSLATPVTGIIIFFVNLGSSVGASVLQAVGGMVLNRQGRQAFPLLVMISALTLVFIGAGLISATYFYRKRHHPNLTPSTNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X520</accession>
    <name>A0A0R3X520_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8524</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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</entry>
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        <source>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000911301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="611" mass="67425" checksum="A9EADD156D8EB9E0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6R0</accession>
    <name>A0A0R3X6R0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020709">
        <property type="protein sequence ID" value="VDM33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6R0"/>
    <dbReference type="STRING" id="6205.A0A0R3X6R0"/>
    <dbReference type="WBParaSite" id="TTAC_0000920501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000920501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000920501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000920501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29098" checksum="F890193203527B61" modified="2016-01-20" version="1">MDLSGVKVQSHQLGQWLVKTTEAHILKALGDERELFESEIDLPCTPEMLFSKNSLSLSTRQGEREAKIEFCALDALKLVDKCTIHVQVPAAKQWSRTHSHKYSILNPFDWTFSTTYEGTMIGDWLVQSTPEGLDQKFIRSRDPILLFGNINLFEDELGDNGISLLNVKIRVMPTGFFVLQRFFLRVDGCLLRLWDTRLQWRLSDKYILREVKRLDSKMWTSTMVGVQADDAEQLCKHVVEYRTEKLFPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X727</accession>
    <name>A0A0R3X727_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS9324</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020762">
        <property type="protein sequence ID" value="VDM34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X727"/>
    <dbReference type="STRING" id="6205.A0A0R3X727"/>
    <dbReference type="WBParaSite" id="TTAC_0000933901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000933901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000933901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16739">
        <property type="entry name" value="RING-HC_RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042741">
        <property type="entry name" value="RING1_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000933901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44564" checksum="824DEACF72EC4C50" modified="2016-06-08" version="2">MAMENAPMKNWELTLYELQRKPQEPITDGTKIAVSPRSLQSELMCPICLDILKVTMTTKECLHRFCSDCIVTALRNGNKECPTCRKKLVSKRSLRRDPNFDALIAKIYPDREEYEAHQNRVLAKLNKQQFNNRASLQESGQSLIHGSNDIDSARYRNRRSAGNNGFATTDSVISEDDAASITGSLNQRASRVNSDAESGTMETTSVGGASSVDFGHPHQQLHNQRVRTFSNNATPASTTTVIPEVELMLRPLPPEHRRGMTLTSSAVSLDSTVVECHGSQVKSEDGGHRATASSPHGTNSELVSEESLLAPAVKYIKVPSNATVDHLGRFLSIRFNLQRVHKDVMENDPYFSLFYYNEASSEYVPLQPSMTIDEISRNYWSGLNSLSLYYLREQSHHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7E9</accession>
    <name>A0A0R3X7E9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020829">
        <property type="protein sequence ID" value="VDM34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7E9"/>
    <dbReference type="WBParaSite" id="TTAC_0000947401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000947401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000947401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000947401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23070" checksum="40F04745E02257BF" modified="2016-01-20" version="1">MQHVIYVTTLGILATAMVFAVHALKVIMQWVKCGRSAMTFEKGNKLGHHCASVWLPQCRIRRCDLVKRYDGAPPTMGLDSGTEMQICALLPSLLHDYLQHRDWEVGFEKCAVVHKTSVYVVGHCFAGCFALAMIVKIIRFGEFIAVNHFQLSHPLHQALPTKEAERKCVDNVDDVVMLTGGRRIRSVIEEWDVDRTVVTTSRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X801</accession>
    <name>A0A0R3X801_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9661</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0000967601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000967601"/>
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    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
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        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
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        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="933"/>
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        <location>
            <begin position="12"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
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            <end position="464"/>
        </location>
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    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="5">
        <location>
            <begin position="635"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000967601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1227" mass="138131" checksum="E9CE015F43DAFF84" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X807</accession>
    <name>A0A0R3X807_HYDTA</name>
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        <submittedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9667</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020967">
        <property type="protein sequence ID" value="VDM34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000968201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23209" checksum="5ABD0B0C793C1E6A" modified="2016-01-20" version="1">MQCQSQFAIERELKERSGGFLADIIQLKTPMSCTAIRKVFSGIGFGLKGIFFLALGFAKTEIHATIILSMALGISGLAVAGYAVSVIELAPKFAGLIMGFANSISTLTGKSLSHLRILSTVIATFIVHYLSTGVGAGWIVAMSLAAGSQFFAAIFFLIFASSQEQAWAKGGVVTNASGDIFHSQKWLAASQRETREKRHHITHLFETDDVEANYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8G6</accession>
    <name>A0A0R3X8G6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9826</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021082">
        <property type="protein sequence ID" value="VDM34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8G6"/>
    <dbReference type="STRING" id="6205.A0A0R3X8G6"/>
    <dbReference type="WBParaSite" id="TTAC_0000984101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000984101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000984101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7446186at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANKLE2 third alpha/beta" evidence="4">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000984101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38897" checksum="8281D1A60F93115C" modified="2016-01-20" version="1">MYLAKPEELRAQRAVASWRRPRNPFWMNLRLMDAEKGYERYGRRLAAELNTKWTEYWTFLDDFADLRSDYGLGLLNDYLAQFYVSDKKTQQSSPATHGSFPYRLPDLDGSIQESIPKRTPSKRVKCEQNGASAMLSNAKEKLCPWTAYREDNNPEHVSSDSFEGSSSSSTSSSSGNSSIDVDPKALSPKQMSPVIGMLNNFIVSSPLRLILPPSCASGSSPTISRPEKRISMFSHGEAVTSTTLRRIPLAPSQKTPSTMQKSARRHVIDGMWPSLLDARTPDRGGRTKYLQASITPAEISVRNALNCDVAPNESSNRNGLKEDRVDLENYPFVKQWKRELDLSLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8H9</accession>
    <name>A0A0R3X8H9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">One cut domain family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9839</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021095">
        <property type="protein sequence ID" value="VDM34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8H9"/>
    <dbReference type="STRING" id="6205.A0A0R3X8H9"/>
    <dbReference type="WBParaSite" id="TTAC_0000985401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000985401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000985401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068888at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000054">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="13">
        <location>
            <begin position="410"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="521"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="523"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="672"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000985401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="836" mass="92492" checksum="1CCBA3E4AEE42341" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H9</accession>
    <name>A0A0R3X9H9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10189</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021406">
        <property type="protein sequence ID" value="VDM35169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9H9"/>
    <dbReference type="STRING" id="6205.A0A0R3X9H9"/>
    <dbReference type="WBParaSite" id="TTAC_0001020401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17958" checksum="1F43E1DC1BD0A04D" modified="2016-01-20" version="1">VFEVDDFDEEIVATGANWPLALGGLDDAFRNRKRQKKGRGGHDYVSQNILSHLGTLAMSGDVQKGKKLFVQRCSQCHTVDKGGVHKTGPNLHGMFGRQTGQSPGYDYTAANKNKGVIWSEETLDEYLINPKKFIPGTKMIFVGLKKESDRADLIAYLKEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9L5</accession>
    <name>A0A0R3X9L5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10225</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01021444">
        <property type="protein sequence ID" value="VDM35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9L5"/>
    <dbReference type="STRING" id="6205.A0A0R3X9L5"/>
    <dbReference type="WBParaSite" id="TTAC_0001024001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001024001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001024001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001024001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42767" checksum="EDF158D877512B39" modified="2016-01-20" version="1">MAKEMRWYDHSVFYRFRAQVFVFMFGCSVTILPILCLVYYTRQFIYPLFRMTFGNAIDDAQSRYCFLSILLYTIYWIWDIETPYRGGRRIMWIKELALWKWMAQYFPARLVASRELQKWASEQGQTVNEKDTVVRLPTSVNYLLGYHPHGPLAAGMLMTCGFDALNFSKFFPDIKPHMATLNVHYKVPFFREFALLAGGVSVNQESLTYLLDRELTGKTGNLVAVSVGGAIEALESRPGQYVLMFSRRRGFFRMALRTGAYLVPSIGFGETSMYNQVANSTGSALRKLQDWFTRTFTLAPPLFYSTCIIPYRKPLTVVVGRPIVCKRTPHPTEGEIDNLREEYKEELRAMFNKYRPIYDPTAEDIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA16</accession>
    <name>A0A0R3XA16_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10376</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021615">
        <property type="protein sequence ID" value="VDM35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA16"/>
    <dbReference type="WBParaSite" id="TTAC_0001039301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001039301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001039301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133330" evidence="1">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001039301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27444" checksum="6216D4A2C3E9E17F" modified="2016-01-20" version="1">MCMHGHNSRQTALLLIIVITRLPSGTSPLFEPLPNATASMKIVSPLLTSCLYPLLYISPSVISSNVGTDERQLDTSAWVDTVSFRMPLKHNHIPNANEVSFVQCVRFGCMHHHTVWSAGDTCGSVWGGKWLESSLRWFRGNHNTMKLMWNVLALVKHNVEFLTVSARPLVGTGRTVKATVGTEVGQLVLRNLKPNTLYVVKVEAYRDRVVLADYETRVYSWPTGEIYSSVCFFFRNSAFTSASHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAG8</accession>
    <name>A0A0R3XAG8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10528</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021806">
        <property type="protein sequence ID" value="VDM35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAG8"/>
    <dbReference type="STRING" id="6205.A0A0R3XAG8"/>
    <dbReference type="WBParaSite" id="TTAC_0001054501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001054501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001054501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001054501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23506" checksum="273FA8EF008D7E8E" modified="2016-01-20" version="1">MKDGNNITHMVKKLSIRFDNAAAPYNPVIDREFVFKPSLFPTMNFSKFYLNGKAYNIPGVFIVLIVHFLVSTPWFDCWRHLFISNLDCHEHEFLTRYLGCLFVVTTRNPDTLGAISSLVQQQAQLLKSQPFRWFSSTNILLKHFPFRFTFRGTKVFQTLTSTYGNANCYFLDLGSSSNFSDSWKSDQIEEAKSVLKPQLTRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAH6</accession>
    <name>A0A0R3XAH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10536</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021817">
        <property type="protein sequence ID" value="VDM35516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAH6"/>
    <dbReference type="STRING" id="6205.A0A0R3XAH6"/>
    <dbReference type="WBParaSite" id="TTAC_0001055301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001055301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001055301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF6">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001055301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35824" checksum="04CCA0861A1052C2" modified="2016-01-20" version="1">MNIVTGILLLYCSEEEAFWLLAAICERLLPDYYDSQVVGVRVDQAVLYQLASQHLPAIFTRSSPASLLSLPSASKGVEYFSSSVTSLFERAGTRSTTDSLNNNSGVELVNLVTFSWFLTLFLNVAPFRCAVFIIDYFFFGGAKVIFQLALELLRLHQPIFSASSEREKVSGTLLHLSRFFHHLIPEVLPLPSATPSDTKMGAVARTEISLRPLSVGMVSHSKAVTVEQLLKSARANFGEAVTCERIESLRLACRLHVIHALSDNCVKEAIRTLQPQFFCKLVDLAILCFSYKFANAFTVGVVSMQCLKILLVFNAVIFNYPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAK1</accession>
    <name>A0A0R3XAK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10561</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021860">
        <property type="protein sequence ID" value="VDM35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAK1"/>
    <dbReference type="STRING" id="6205.A0A0R3XAK1"/>
    <dbReference type="WBParaSite" id="TTAC_0001057801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001057801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001057801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="6">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001057801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30490" checksum="2D9BA3910CBEC994" modified="2016-01-20" version="1">MVEFEGLSVPISHLGRVIRVAGEVSLMGHNLETTTERLTVLTQCNAPIVKLLANYKHGILLVITEENMLIEYQFNDEYCRSMTESFRLKLASQLNERPCFIWAGEMVLAMALGEGVIRMWDIKKADNYTLSPRSTSDLRTKSSTTIEILAFCPKHELLAAGMSDGRIAIWKHTDVTPSHNAFTAEKDIHSYYSKTMEPVFGTFEPESCWRAQPIIDLFVNHAEEHLRDSCTNTAISALVWDPTTGLMAASYGYSSDPANGEVTIYYPARWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAV9</accession>
    <name>A0A0R3XAV9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10669</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01022022">
        <property type="protein sequence ID" value="VDM35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAV9"/>
    <dbReference type="STRING" id="6205.A0A0R3XAV9"/>
    <dbReference type="WBParaSite" id="TTAC_0001068601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001068601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001068601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133307" description="tyrosine--tRNA ligase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001068601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="38761" checksum="E21991CC1213B1CD" modified="2016-01-20" version="1">MSFLVSLLVFMLAAQVLKAQLVATGYPSLSKQGSYSEDVYRISADTSVRDARKAGAEVVKQVANPLVSGLLYPLLQALDEEYLHVDAQFGGVDQRKIFVMAERILPRLGYRKRIHLMNPMVPGLTGDKMSASEAASKIDLLESSSSVQAKLATAACPPGQRAAEGNGVLAFIKFVVFPLVNLAAPGSGVKVGDMSFATFNDLEAAYVAGVAEVSPEALRACIFEHLDPRIEVVRQRFTEPRLLKLLSDAYPADDAHCVEKHAAESGSASLTAVFSDDGLTDLKNRLSSIESQLPSLEPSSLKSIADLLLLNLESLQPLTSRRVLRCMWSIAPSGVPHLGHTLPLRLLARLSCISGVHVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB36</accession>
    <name>A0A0R3XB36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone H2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10746</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022182">
        <property type="protein sequence ID" value="VDM35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB36"/>
    <dbReference type="STRING" id="6205.A0A0R3XB36"/>
    <dbReference type="WBParaSite" id="TTAC_0001076301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001076301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001076301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001076301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8245" checksum="699416C00CB1964B" modified="2016-01-20" version="1">MQLRGDCAHCVSDIAPVCLAAVLEYLVAELLGVASGVVVDNERGCMFPRHLHVVSCEDEEQNNFAANMTTPPPSMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB60</accession>
    <name>A0A0R3XB60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022219">
        <property type="protein sequence ID" value="VDM35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB60"/>
    <dbReference type="WBParaSite" id="TTAC_0001078701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001078701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001078701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6237019at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001078701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20396" checksum="C6752BEDDA4AE355" modified="2016-01-20" version="1">MPREPSSPTELANPQPQQIVRLLLQVARRDLPFIEQMQTSCFRVPRLFLLDCRRNLLAHERDNDPPLQCSLRYCIPLGSENPPIASLQQPLKASALSSGATTPTSQLKGSYQRKLFGSVGSPAPSTPPPTDETKPPTPHTTPAILKPLRTMSFKFRVRRSPFKRRPLKAIQLPTLSPVKDGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB70</accession>
    <name>A0A0R3XB70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10780</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM35760.1"/>
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        <property type="protein sequence ID" value="TTAC_0001079701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001079701"/>
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    <dbReference type="Proteomes" id="UP000274429">
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    <dbReference type="GO" id="GO:0005509">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="48"/>
        </location>
    </feature>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001079701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16508" checksum="D20C8511D01EFEDC" modified="2016-01-20" version="1">MRIQTGPTQDLQRGNNFVDSMLSMFDSNNDGFLTKVEARKAASQFDIGSRELKGALNKIGIDKKEDSIPLDPMSEQIKRICVEKFNYMDLDKSGTISLDEVLSAIQAFNMPASISLARQIFDSVDSNRDGEIDLKEFLAFLASVKDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDM6</accession>
    <name>A0A0R3XDM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11636</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01026208">
        <property type="protein sequence ID" value="VDM37599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDM6"/>
    <dbReference type="WBParaSite" id="TTAC_0001165301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001165301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001165301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001165301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7574" checksum="D080BC0797B805EE" modified="2016-01-20" version="1">MSYFKSTCARLHAPPPNFTILTTVLASLCDNPSLLCLLPGALTPSSPPSLPPSLPPSSSPQSPLSLYRTGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDD6</accession>
    <name>A0A158RDD6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS430</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000036">
        <property type="protein sequence ID" value="VDM16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDD6"/>
    <dbReference type="WBParaSite" id="TTAC_0000042901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000042901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000042901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="179"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="297"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="452"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="563"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="681"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="809"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="913"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1368"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1383"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000042901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1408" mass="153263" checksum="144C4B0A5960E9CF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDN4</accession>
    <name>A0A158RDN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000168">
        <property type="protein sequence ID" value="VDM17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000105501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000105501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000105501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288461at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056343">
        <property type="entry name" value="CFAP47_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24529">
        <property type="entry name" value="CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="682"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000105501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2215" mass="248794" checksum="344B2ABF46E2090F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REX3</accession>
    <name>A0A158REX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020473">
        <property type="protein sequence ID" value="VDM32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REX3"/>
    <dbReference type="STRING" id="6205.A0A158REX3"/>
    <dbReference type="WBParaSite" id="TTAC_0000827501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000827501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000827501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000827501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="37134" checksum="C2F798C001D61596" modified="2016-06-08" version="1">MEKTASRMYGGLLSPGMIGSFGGFMPAPPPPPSNFYDLTAFQQQQQQQQQQQQRLLQQQQQQQRPSSNSATSTSSTSGSSATPSTTSASGSGGGGGVGGVDALSPSSTSSASALHSELFNAASERERGGAPLLLRLAFPKSLLFSPLYIAMLDFAWLFGITTRDATSATIGEVHKSCDRSGDKPQASKNPFQSFYAVFAAAGFYGMAAYGQPMPSHFSVAPPSPYAAPSAGRHFAAAAAAAAAVLGSCFYPTRSPPEAAVFSPPPPPPPPPPPAPAVPSGPAAVPPSLPTAGTANSSGAALSAPATPAAQHSSASSASASAAAAAAATAASATAAASAAAAAAALLSSPLAAVAAASSPSFTPKLVNRPLLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EN12</accession>
    <name>A0A3P7EN12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003816">
        <property type="protein sequence ID" value="VDM24331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EN12"/>
    <dbReference type="OrthoDB" id="10035553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="162" mass="17413" checksum="00D46FB924BD0E1B" modified="2019-02-13" version="1">MQRYYDNLLAKHAAAEMTIDHLRIRAKVGCEDSTLPPASSTTPGNTFSNTLRGRKLTSASLDTCVPALLSKRSHQPRVSGSVASFRDHSTPTRSQCSLNPTPRVSMQPQVHLMPLASSSKHSQRSRLNDGLERPKSGLNNAPNGEGTVASVDDSTDFEGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EP62</accession>
    <name>A0A3P7EP62_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000452">
        <property type="protein sequence ID" value="VDM18404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EP62"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 C-terminal" evidence="1">
        <location>
            <begin position="535"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="858" mass="97268" checksum="02F1257283BC9BC3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EPD0</accession>
    <name>A0A3P7EPD0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002763">
        <property type="protein sequence ID" value="VDM23013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EPD0"/>
    <dbReference type="OrthoDB" id="10044468at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="3">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="129" mass="13869" checksum="FDE25C3EE7F25DCD" modified="2019-02-13" version="1">MALRVRQDFPSLLPHASLFDGKEVAIGSEFSAGTFVPHSPPPSPPPLPLPSPPSLSTSRIAFTAESLPACRMDRPDLYEARQCNALDCFCVNVTTGVFLPGTRTSIEDLVDCSTGRIKTLFCTLALFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EST5</accession>
    <name>A0A3P7EST5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006411">
        <property type="protein sequence ID" value="VDM26361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EST5"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM26361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="135" mass="14621" checksum="FDDFAFEF92277E05" modified="2019-02-13" version="1">MKLCTPSVNVKHHQAYLMSNSLLAHNGYPRIAFAACIGSPLFNLLIGAGASYTIKLARSGDHTMSFTLTHVLLFSFLMGVLTTNLIVACVTGFQMRRAYGICLLCAYAVFMTLAILVEADVIVPPASWHLLTGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F6E2</accession>
    <name>A0A3P7F6E2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003648">
        <property type="protein sequence ID" value="VDM24159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F6E2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="330" mass="36140" checksum="AA67E6E6CB233A96" modified="2019-02-13" version="1">MSAISSADVFHANDHGKAQLTALPNFMRLKQYALFNPPRHPIMHADESGFPCCPVSHAIRLRGTKLLLSFALPEPMAAVPPNHAYPASNDYRPCPTTTVSPETMQFCPTFLHQGHKTATAFDRLNPMLSPSMLLAALKNGVKSQAHLCCRFVDVGFVVACLHHLLTRTNSPSNTGIRLDPSGIAELRTRHSPPQSTCATDSSKCSARSSPAPPPPLILPNPPWGTVQGAPRGQSRTVPHLPHTMPYFPPMPVPTSHHTAIVQQRHQQQQCCSYLQQQQQYQPSLIMPVAGHLAQETPHPPVLSVIELEDNSSQDVDQMSQSRGTKLITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F722</accession>
    <name>A0A3P7F722_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L49, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020357">
        <property type="protein sequence ID" value="VDM31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F722"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L49, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="9">
        <location>
            <begin position="444"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="517" mass="58329" checksum="BC474ED5204FCB67" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F9U7</accession>
    <name>A0A3P7F9U7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 3 cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005037">
        <property type="protein sequence ID" value="VDM25419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F9U7"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="105" mass="11667" checksum="AD7A016FB1538A41" modified="2019-02-13" version="1">MVGETYFLRHPVAAFVRLREACRLGEMTEVPVPTRFMFILLGTAGNGAKYQQIGRAMGTLFSDEPPFLSFLFISPPVLSTLSFEIHPLIDGASNDPWESNFSTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FB19</accession>
    <name>A0A3P7FB19_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005503">
        <property type="protein sequence ID" value="VDM25777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FB19"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="203" mass="22994" checksum="FD8300D0B998ECF4" modified="2019-02-13" version="1">MLYTYVSTFDFFNGSAGKTRLRVVIYYFAYYVENSAMIGAWYAAYPFTASWYYLPALLVVVTVQWIGAIFLQVYFFYFSASPRGTSLCGLCCPDELRGPVELVYSPLPFTYPPVQNAQPLPPPPVDNPSFILQSTSLYSQRGRLGPQSSHEDPSRTDSLTVVTAEMPRKPRSRYLYVRSPPEAELMEEWNDVDGFIPPDDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FDK4</accession>
    <name>A0A3P7FDK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006813">
        <property type="protein sequence ID" value="VDM26597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FDK4"/>
    <dbReference type="OrthoDB" id="6276199at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="153" mass="17254" checksum="CAF93F91A71DF3AB" modified="2019-02-13" version="1">MHGIEEDVDPDVVWTPAYYGDVEDFDAKEEEVDANHNWLIFSTRDAHLLLKKGPHGDSYPITGRYDAHIDGRVVTGKLLSELIRSVHKEGEETEAKQRNRVSLVYYKDLQHYAGRAEMKALGREDTTTIVKKGEFGGIAVTSYPNEEALMSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FG84</accession>
    <name>A0A3P7FG84_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01009581">
        <property type="protein sequence ID" value="VDM27904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FG84"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="113" mass="13289" checksum="A8DD01B32B1F07B0" modified="2019-02-13" version="1">MLNLFFSDWSTKDIRRHLPFTYNCISQAFYSYPPAMKRFGSQIRVVHFIGAAKPWHQQVNPETGSLTPCDEISAQSLRFLNFWWHLFFTDIKPKISPSVVRLFFSSSAHWLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FPE9</accession>
    <name>A0A3P7FPE9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021812">
        <property type="protein sequence ID" value="VDM35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FPE9"/>
    <dbReference type="OrthoDB" id="10001713at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="148"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="272"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="445"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="544" mass="59827" checksum="685AA0184B62C160" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4I6</accession>
    <name>A0A3P7G4I6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022959">
        <property type="protein sequence ID" value="VDM36079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4I6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="78" mass="8956" checksum="C21AB27B7E382434" modified="2019-02-13" version="1">MRVRRRRTDSSILDKNYSGCALVPLSPLPTSRALPPVMTHWLVRRRHCHGLALIHAKLLSHAYEVCQTPAELPPYHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6U6</accession>
    <name>A0A3P7G6U6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022650">
        <property type="protein sequence ID" value="VDM35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G6U6"/>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="227" mass="25535" checksum="6A0B5033A98973EA" modified="2019-02-13" version="1">MNGSDRTKNERTPTCPSSSDGTLVISPCPRNSPSPANTASDFRNHPQKRHSPLDSHVVNDAPQHRRNHSSEEDEDTMNLLSSSASESRHYPLSLDAPEVLQFVDSHLSMRFQHPVADTLETEAQSLLRNFDRLHSVLYSELSGELKKLRALEGISARTHGRDRIEKGTSSFGFTRCTNLNAAILLAERVQPFTSFHSVSALQWQLQATYSLSYRSHDRESFHPRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GK65</accession>
    <name>A0A3P7GK65_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01002801">
        <property type="protein sequence ID" value="VDM23068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GK65"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="6">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="170" mass="20040" checksum="9CF30B3C7C7B31BF" modified="2019-02-13" version="1">MLSGLIKVDLVITYMSKSPVPFVYSVFVRNENPRYRFTAEETARMLSKNCVHLLPPHHWRRTKMVAWVVSNCHPANNRIDYANAINNFIPVRHDMVPIVLGAFKEDYEGLLPPRSYINVDDYRTIRELTDYLLYLDRNDTAYATYFAWKEHGSFHVRFEYCFNQKLLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GPA7</accession>
    <name>A0A3P7GPA7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RSE1/DDB1/CPSF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003443">
        <property type="protein sequence ID" value="VDM23942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GPA7"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM23942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="236" mass="26662" checksum="B6447C07913942B3" modified="2019-02-13" version="1">MQHFPNLINGIYGIGHRILVTDVQESLFWVRYRPRADNQMVIFADDASPRWITQLAVLDNSTAAVADKFGNVIILRLPPDVNDNVEEDPSGNRSLWDRNALGGANQKLEMVCHFYVGEVVTSLQKATLIPGGSEGLVYATLSGSLGILIPFASKDAYSFFQHLELHMRTENISLVGRDHLHYRSLYYPCKNVIDGDLCEMFNTLDAEKQRNIAEEMDKVPTDIAKRLEDMRTRCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HKI2</accession>
    <name>A0A3P7HKI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022416">
        <property type="protein sequence ID" value="VDM35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HKI2"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="625" mass="71003" checksum="CA42350F43B5AF2B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHU2</accession>
    <name>A0A0R3WHU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS131</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000009">
        <property type="protein sequence ID" value="VDM15926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHU2"/>
    <dbReference type="STRING" id="6205.A0A0R3WHU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000013001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000013001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000013001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000013001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="33341" checksum="CC03762AA9AA190D" modified="2016-01-20" version="1">MRLFLNFEQNVSPTAKLTSNATPRSPVGAGEESFQCKKSLSPPSACRESANAPPPPPSPLVPFCPSTSISTSSKLDSTVSGISASNRVNGCSPPSSSISFSDGSASETTKVKSPPPVKTRPEPPVRRTPEFNGPVAPASRKIGLLEVDTTQVGAVLVAVAATEMESVEDEKHIGSLSPPPPPPQMQLHYPYPGMQGNTHHPPVRTPRSAFGGGHFGASSSASHFSGARVPLRSPTSPPTAPASHQFPYVQPQRVFSSGSRFAGGCGSGLRKTAPILPQQTRASTVSASQGGPIRSAPTAAPRVVVTTRAAAAAGQGNLYINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI00</accession>
    <name>A0A0R3WI00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal_L30 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS195</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI00"/>
    <dbReference type="STRING" id="6205.A0A0R3WI00"/>
    <dbReference type="WBParaSite" id="TTAC_0000019401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000019401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000019401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF58">
        <property type="entry name" value="IP16805P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000019401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29763" checksum="EF1FEBC0B57F4E03" modified="2016-01-20" version="1">MEERIGEEKPLPKLPTVPVKLLKRRKQKNRDVIKQQRIRSREIRRRAHERRKVFHRPAHFISVSVCIFTPCVKGARKEARDKARIARELKLKPPVAGPVRLGIVIRVHGDRGLSADSLKVLEILNLNIPNSAVFVKTSEAMLEVLTLVRPYIVWGYADLATVRNLIFKRGKTKVGGKVRSIDNTLVESKLGSLGILCIEDIIHELVTLGPHLRDVLGFLCPFTLRRPIGGWGRHLKKSQHPFNRLVGNRDEMIGELIYKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIJ2</accession>
    <name>A0A0R3WIJ2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS422</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000035">
        <property type="protein sequence ID" value="VDM16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIJ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000042101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000042101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000042101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000042101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="72811" checksum="793A8FF6D4D5B270" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ65</accession>
    <name>A0A0R3WJ65_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS695</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000079">
        <property type="protein sequence ID" value="VDM16854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ65"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ65"/>
    <dbReference type="WBParaSite" id="TTAC_0000069401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000069401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000069401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000069401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14957" checksum="AD8A9E9A7715D003" modified="2016-01-20" version="1">MSKRGRGGSSGGKFRITLGLPTGAVMNCADNTGAKNLYVIAVFGVRGRLNRLPSAATGDCVVCSVKKGKPELRKKVWQAVVIRQRKAFRRKDGTFIYFEDNAGVIVKSNGEMKGSAITGPVAKECADMWPKIASNAGSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJB3</accession>
    <name>A0A0R3WJB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TROVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS753</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000089">
        <property type="protein sequence ID" value="VDM16938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WJB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000075201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000075201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000075201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052652">
        <property type="entry name" value="Telomerase_Complex_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44791:SF1">
        <property type="entry name" value="TELOMERASE PROTEIN COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44791">
        <property type="entry name" value="TELOMERASE PROTEIN COMPONENT 1 TEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132839" evidence="1">
        <location>
            <begin position="19"/>
            <end position="2682"/>
        </location>
    </feature>
    <feature type="domain" description="TROVE" evidence="2">
        <location>
            <begin position="45"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000075201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2682" mass="294695" checksum="20E40B5645EF798F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK58</accession>
    <name>A0A0R3WK58_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1089</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01000177">
        <property type="protein sequence ID" value="VDM17447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK58"/>
    <dbReference type="STRING" id="6205.A0A0R3WK58"/>
    <dbReference type="WBParaSite" id="TTAC_0000108801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000108801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000108801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000108801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35621" checksum="199B0B779DCD8A43" modified="2016-01-20" version="1">MFGCCRDRNVPPNSTEVISQTRLLSLSSGSVHGHDYDHMLADEMAKRVRVFAVILTMPKSKEVKAVHVKATWARRFNGYVFVSSEEDKNLPSIRAVSSESRNVLWEKTRQGLLYAYENHFNDYDFFMKADDDTYVIVENLRFILLKWDPNEPILMGRRFKKFVKQGYTSGGAGYVLSRGALKLIAKGMNGDIRGCRKGRGAEDVNLGTCAEAVNVTLVDSLDEHEQEIFHPFPPAYMIDKKTMEATSWVHSYNYFPIRTGLNCCSDHSVSFHYVSPSEMYTLDYLIYHLHPYGIARDIEQYDKLLNLRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK97</accession>
    <name>A0A0R3WK97_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000191">
        <property type="protein sequence ID" value="VDM17517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK97"/>
    <dbReference type="STRING" id="6205.A0A0R3WK97"/>
    <dbReference type="WBParaSite" id="TTAC_0000113201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000113201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000113201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000113201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37506" checksum="A7800B771573B58E" modified="2016-01-20" version="1">MDETPSNTAPQGHSTVKRVFVISSSSYSLMDPRIWRLRVQNNKNTFLIPSAYYLNNPDLIPLRRNLAPKTFLERALKGVRYEEFGPNHIFSVRRAALEDINKTTKNLSLHFNRYEISTLLNVYYTLTNYEVRPMKQAELMNFLYLTLNITNVESLQGLYRAGIKLMCHGNFKLMGAFDSLTFVHLMSVLLRGSIEERAVLSFYVLDENDDGLITAKTELAHSLRSSFNPRVAASAPEIDPEEPSRDTLRYLIKKMGLSVDGGLNLDEFVNECLVSPWLIDGILPNLPSEISNYAFQCVVSQVPKLPLIENNAARNRSIVSIKKRKRKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKB1</accession>
    <name>A0A0R3WKB1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Auxin-responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1148</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000195">
        <property type="protein sequence ID" value="VDM17538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKB1"/>
    <dbReference type="WBParaSite" id="TTAC_0000114701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000114701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000114701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10623532at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000114701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9974" checksum="67DF763009D0A403" modified="2016-01-20" version="1">MGGHEIHTRRAYAHVRVGGSIEERTRVPPDYMTRLYQSTTDERGRLLAPPPYYADSVLAFLDEKKKYMICASPPLRGYDAVSDADDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKM8</accession>
    <name>A0A0R3WKM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho guanine nucleotide exchange factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1273</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000244">
        <property type="protein sequence ID" value="VDM17729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKM8"/>
    <dbReference type="STRING" id="6205.A0A0R3WKM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000127201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000127201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000127201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000127201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="826" mass="91154" checksum="CB1C87027140E019" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLN5</accession>
    <name>A0A0R3WLN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000433">
        <property type="protein sequence ID" value="VDM18357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000167301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000167301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000167301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000167301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="78837" checksum="273056C558F62B69" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM09</accession>
    <name>A0A0R3WM09_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1784</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000507">
        <property type="protein sequence ID" value="VDM18524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM09"/>
    <dbReference type="STRING" id="6205.A0A0R3WM09"/>
    <dbReference type="WBParaSite" id="TTAC_0000179701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000179701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000179701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000278">
        <property type="entry name" value="Protein CBG07490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="146"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000179701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30772" checksum="C750F7429039E78D" modified="2016-01-20" version="1">MKTTARAPAMSTVERAVKSVPYPPSRRLTVNDIFESRGKPNIEKLKQHFLLEGRVTDEAALKIINDGAALLREEANVLEIDAPVTVCGDIHGQFFDLMKLFEVGGHPATTRYLFLGDYVDRGYFSIECVLYLWALKILHPTNFFLLRGNHECRHLTEYFTFKQECRIKYNNEVYNACMDAFDCLPLAALMNQQFLCVHGGLSPEIQTLDDIRRAKICDLEMFRPSKIAFYQSLYVRFNHDICYPTSQVGLNPEDFKPCRHRGSCFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM62</accession>
    <name>A0A0R3WM62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-sulfurylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1837</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000545">
        <property type="protein sequence ID" value="VDM18577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM62"/>
    <dbReference type="STRING" id="6205.A0A0R3WM62"/>
    <dbReference type="WBParaSite" id="TTAC_0000185001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000185001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000185001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="5">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000185001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8996" checksum="253A509134D10B13" modified="2016-01-20" version="1">MAPGLAGLEIVPFRVAAYNKVHRAMEIYDPSHADDFIFISGTKMRTLAREGQQPPDGFMSPSAWKILSDFYSRQNRHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM77</accession>
    <name>A0A0R3WM77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000554">
        <property type="protein sequence ID" value="VDM18592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM77"/>
    <dbReference type="STRING" id="6205.A0A0R3WM77"/>
    <dbReference type="WBParaSite" id="TTAC_0000186501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000186501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000186501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288278at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000186501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="31976" checksum="8CCB8DECEE709857" modified="2016-01-20" version="1">MESQAKAPPLPLDVYASSAASVASVPAQAVFVPTQLPPRPTSSPSTLLPLTSIYTSNMAVESQTFEGQAISNAEPNGTTAVRIPTESGDVGNELTPIPVEDGAVAQLLASVEPVAELMESQFQREQNTAKPERENEIEYKEKKKEVDTEQKDLRLDESVTASKELETASIAPQPPPPSSSPVTATVAADIDVAVAVVEEKSKKAEDDEVGDTVTQRSFSPPKSKSGPVVRVVRKRRRVLSTLQMMRSYADTLQPVDCVILVERCAPFSRNTSFMEYFKTEFLSKILRWATSNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMN5</accession>
    <name>A0A0R3WMN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General transcription factor 3C polypeptide 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2010</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000683">
        <property type="protein sequence ID" value="VDM18750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WMN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000202301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000202301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000202301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="6">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="5">
        <location>
            <begin position="161"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000202301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55967" checksum="C038FF7FBEB50BE3" modified="2016-01-20" version="1">MESVIPPREFFIVQYPGIVRNDDRAIETLGGLQSLSKSFNSLTRRLRLSFRPEMLFAKPVYGDPHSKTALIIRAKQLRNRRTGELKFTSEIVGIASRIYSFNAMFDFQYGPFERISANLNETAPDCASPSDSFRVFYDRLLVKGPTRVLDSHLRAPDVPLFLPPLLFTRLDQPTMYCFSSRFRMNEYVELENNSQQHPYRKRLPHIYPYWSVCWVFQGTYALPDLPKPHIKYRKERKSYAMFVNFGDPVPSAAHPGALQAITSLGPHTRKLAHDVEKLFRRRPIWGKAALVHSLNWKRVRECAIKTILPAYAYYVPNGPWGRVWIRFGYDPAENPSSRIYQTVDYRVRSPRLQAKLCISGRRPRVDDREDTDFSGSDVDEAKDTSLVDAALAAMHSESPSPVHASSKSTSAFRFSKTSWPDARQILYQLVDIDVPEVVEMLAAPMCRKICDPNHGWMPADYQKTIREVMTRYLETWVLGNGTLSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMU8</accession>
    <name>A0A0R3WMU8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth hormone-regulated TBC protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2073</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000731">
        <property type="protein sequence ID" value="VDM18849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMU8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000208601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000208601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000208601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000029">
        <property type="entry name" value="Growth hormone-regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000208601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39049" checksum="D0B1C16BB96FC784" modified="2016-01-20" version="1">MSLSGAFEMMKKNPKVYQTASVTQPPKNIFTTIMADLPRTFPENAHFSQAEGKGDKLQALQRILVAFATSFPKIGYCQGLNYVAATLLLAMQGLPDAEAEERAFWLLHTLSHHIVPNYYSDRMVDVRVDCLVFEELLKKKAPNIYRTLKNANVDCVVLATKWFICLFADVLPIETVLRIFDCLFYEGNKILFRACIALAKLHTREILYCQQFPDVVLTFRDITQDKQTLYCHEFLKAMFTLPGSLPRSLIRKLRGKCLEKVKITLNELEAQERDYRERMALQNQQQQKQTQQDEEQTINDSYSGEFGDSDDESEEMLKAQQSDDAESSPSLNAPINHGIGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN45</accession>
    <name>A0A0R3WN45_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Utp21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000818">
        <property type="protein sequence ID" value="VDM19113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN45"/>
    <dbReference type="STRING" id="6205.A0A0R3WN45"/>
    <dbReference type="WBParaSite" id="TTAC_0000218301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000218301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000218301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000218301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16151" checksum="A41895B29F5BADF0" modified="2016-01-20" version="1">MSRLRRLTPSALDIEMRLLAPSRDALVEALAAIDYSNGGGVSLSFNPYARLSAFLSLLLNRFRRNLDFDLATACLEGLLRYHGELIARPPKAPTSIPTKPFSADQDDSGDAGSFCLGDMVAAETGCRNDHLDADRPLELMEAVLEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP88</accession>
    <name>A0A0R3WP88_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001216">
        <property type="protein sequence ID" value="VDM20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP88"/>
    <dbReference type="STRING" id="6205.A0A0R3WP88"/>
    <dbReference type="WBParaSite" id="TTAC_0000257801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000257801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000257801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258762at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000257801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="823" mass="90315" checksum="D58E56FDF1B3D572" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPS3</accession>
    <name>A0A0R3WPS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cleavage and polyadenylation specificity factor subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2748</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001465">
        <property type="protein sequence ID" value="VDM21067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPS3"/>
    <dbReference type="STRING" id="6205.A0A0R3WPS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000276301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000276301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000276301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242961at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="7">
        <location>
            <begin position="397"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM21067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000276301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="603" mass="67449" checksum="943F9D41BB903777" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQH5</accession>
    <name>A0A0R3WQH5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3000</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001788">
        <property type="protein sequence ID" value="VDM21715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQH5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000301501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000301501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000301501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000301501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15819" checksum="39061E0A28E4E029" modified="2016-01-20" version="1">MSSHLQWMLIKNTHCFLMKRNGEQFSRDPLNMKGKNCFKYNGMVHKKAIGIKQMKGGKGVYFITKRTGLDYKPSKALVRIKFVRGNRRTLQNIRNFVCRTKYRRELKMLALRKASAILQANKRKQVSPTKKAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQN3</accession>
    <name>A0A0R3WQN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CG-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3058</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001862">
        <property type="protein sequence ID" value="VDM21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000307301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000307301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000307301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285782at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000307301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15355" checksum="3D2B6276E059845A" modified="2016-01-20" version="1">MLTVQSNSDYRRSGGYGHHQGNGHYYSSFYGSDSHSGGHDSSGGGYGGNYHHHHHHSGSGGTGGHIGSGGGGGGHGAMDATFVWKLSKLGRISSSRLRFDDDFADRLNYQFSGVLMFLFIGVIGIRQYVGTSQQILTSDSSMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQS2</accession>
    <name>A0A0R3WQS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tissue factor pathway inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3097</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001921">
        <property type="protein sequence ID" value="VDM21945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQS2"/>
    <dbReference type="STRING" id="6205.A0A0R3WQS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000311201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000311201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000311201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000004">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000015">
        <property type="entry name" value="WAP four-disulfide core domain 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="147"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000311201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="39907" checksum="01CEAE00F6093520" modified="2016-01-20" version="1">MAETRYEEVNYSKQHGKSSCCLKFWLAFFVIVSLALIGVVLWLLLAPNSASDLNARSRAALQTASGTNRPGLCALPPAQGPCKATIWRYYFDATSGECKKFIYGGCSGNANNFISIQECMNTCMLLPGSKSSNMIIILIERPKPKFCRLEMDPGPCFGAILRYAYDEKLGKCVEFAYGGCDGNANNFETLEECERKCVGELEPGTSSDGGISAVDTTLCHLPHDPGNCYAHIQRWAFDANSGQCVQFIYGGCGGNANNFETKEACERRCLANIPLARPATGDDGLPDAVCSLPAEVGPCRGALKRWYYDVSKGQCTEFVYGGCRGNANNFESKEACEARCSGELSPPPSSLFYSLTNFLSTNFFPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR68</accession>
    <name>A0A0R3WR68_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3243</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002115">
        <property type="protein sequence ID" value="VDM22228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR68"/>
    <dbReference type="STRING" id="6205.A0A0R3WR68"/>
    <dbReference type="WBParaSite" id="TTAC_0000325801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000325801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000325801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000085">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000325801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="59170" checksum="1DDC884193D56C30" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRC7</accession>
    <name>A0A0R3WRC7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3304</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002214">
        <property type="protein sequence ID" value="VDM22355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRC7"/>
    <dbReference type="STRING" id="6205.A0A0R3WRC7"/>
    <dbReference type="WBParaSite" id="TTAC_0000331701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000331701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000331701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6243207at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000331701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43722" checksum="05B5D9194D5F329E" modified="2016-01-20" version="1">MVGSVLGAFGKSRIPQSNQSDRSADGERKTLFLRGGWNKQFRPSKATCRVCLHDYENEEGLTKHIEEFHVPETRKRVQHLADVGEMQLKLTDMKHQWCVTSLQVHIIVAHGGKSWCNCGLCDQQFCEPNQCLPAFLTVGPVVTITEDENQSKWEPPEEVISTFTEPPSVERFPAFEEDLDVLYSFYEAKLPIVTLCRILDCHEAKHQITLQSPLRFPFLPVKLITQLLESRGHQGKQIFDWLSVISDQSLMLDIKPFIYDDPNSKKDGKGKITFRLNPGEDPLSQEGVEMGKRLLEAMVLNIIGLVQRSNSDVEEEAIMMEPEQKVSETSQNTSDASIHSPTKGSTSTEAVATVQKSSLPHKLIKLFTRIGEHNVAVHQEKDFIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRL4</accession>
    <name>A0A0R3WRL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3389</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002359">
        <property type="protein sequence ID" value="VDM22533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRL4"/>
    <dbReference type="STRING" id="6205.A0A0R3WRL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000340401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000340401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000340401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating transcription factor 7-interacting protein Fn3" evidence="1">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000340401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="30950" checksum="2C84C0DAFB12725B" modified="2016-01-20" version="1">MRTDSSSPSAVFQAETLNGVDVPIAQTKEGIRSEVLKLLSRNLSPHLNDLVDSLKSAVALCNKLTNDVEEMQGSVATCTASVRETKDKVPDQIVPMATTSASKALLESSKEQRLPPHLVNRLLLRKSLTNKNDSANLNGVRSSFAKAPRDFFAIQAPPLPNYTPPDITLNIGGSIVIVPMQPPLILSASPAVGGISIEGRLDQSSLTLQFQPANVYYLYSYTPTDGDAIKVQLGIAWTKIAVITAPNLPLSFVAVNLPPNSVHFFVMHGVDALGRTGEWSNIVKAIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRL6</accession>
    <name>A0A0R3WRL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002367">
        <property type="protein sequence ID" value="VDM22537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000340601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000340601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000340601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6088000at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000340601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21658" checksum="1FF849CEF992FC19" modified="2016-01-20" version="1">MRRSAVANNPKCKIHVVSADPLCSNFRPYLYNSEFRYAIKERGGGEEEEEKEGITEQVQVRLRLCLALGGEREGEEELTCLRLTEGLSLNTLASYATTLSQLTAAVLAFDDLEVEMEENAKACGSLIAPSYLLHLTDAPARLQFILSLVAHWLPRHLLRLASEQSHVECRQLLEVQFCFTFVSHPIASHTILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRY1</accession>
    <name>A0A0R3WRY1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3505</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002546">
        <property type="protein sequence ID" value="VDM22765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRY1"/>
    <dbReference type="STRING" id="6205.A0A0R3WRY1"/>
    <dbReference type="WBParaSite" id="TTAC_0000352101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000352101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000352101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000352101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11138" checksum="8F61CFC312F755BF" modified="2016-01-20" version="1">MLCQAIGKSGPRLDIPLMLYQSAPEKEARRSDLGQDEGQEGMEEEGGEESDGGKMLPPSLPSPPPPPPPPKRSHIETFYLNTTKWRTRRDAVSEKIDYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS32</accession>
    <name>A0A0R3WS32_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase 5 activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3557</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002634">
        <property type="protein sequence ID" value="VDM22869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS32"/>
    <dbReference type="STRING" id="6205.A0A0R3WS32"/>
    <dbReference type="WBParaSite" id="TTAC_0000357201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000357201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000357201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000357201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84867" checksum="A3698B1703D15CF8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS63</accession>
    <name>A0A0R3WS63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002688">
        <property type="protein sequence ID" value="VDM22927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS63"/>
    <dbReference type="WBParaSite" id="TTAC_0000360301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000360301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000360301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000360301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12760" checksum="43B44449CFCC5110" modified="2016-01-20" version="1">MQCKTEFPSSSVVRVTTNAMVILPGPHFAGATVIRLISQYPYARDVQLCVGSTLSHHLGLRHCARSHAHRLVDLHVPSMSATRNRTNKRTEVMQEKAMQRSPPSHQVGRLHKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM7</accession>
    <name>A0A0R3WSM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3752</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002981">
        <property type="protein sequence ID" value="VDM23287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WSM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000376701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65923" checksum="72087A528D10EAEE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT81</accession>
    <name>A0A0R3WT81_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS3956</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16149"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16151"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01003359">
        <property type="protein sequence ID" value="VDM23850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT81"/>
    <dbReference type="STRING" id="6205.A0A0R3WT81"/>
    <dbReference type="WBParaSite" id="TTAC_0000397101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000397101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000397101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinamide phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM23850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000397101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27763" checksum="BD17502A3CA466DA" modified="2016-01-20" version="1">MSESFLNGYESGDYSSDQANIICLSDSYKYPPGTTEVYSYFESRGGKFSETVFFGLQYILKKYLVGSVVTERKIREAKEMMREHFGRDLMNEDGWRYILEKHNGRLPIRIKAVPEGTVIPVRNVLFTVENTDPNCFWLTNYLETVLVQVWYPLTVATNSLEFKKIIFKYLQETSDDLSPLPMLMHDFGFRGVSSIESASIGGTAHLVCFRSTDTMAALLFAKRYYNCNMAGFSIPATEHRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTC6</accession>
    <name>A0A0R3WTC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003452">
        <property type="protein sequence ID" value="VDM23949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTC6"/>
    <dbReference type="WBParaSite" id="TTAC_0000401601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000401601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000401601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273101at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000401601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16294" checksum="374A3AB715EFE531" modified="2016-01-20" version="1">MGSARVSGSGTSDNMEECSAQPLPSSQFPRTLYVHPERKQIFSCSTTPFYGHATIKWFGALTVNDAEWYDLTNLTSIAELKRGGINGASYIKTVSLRLPPANSMRLGALQCRGYPSADVDYTTHTSIVDQVALKPYGSFIFWFTNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTZ8</accession>
    <name>A0A0R3WTZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4223</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003951">
        <property type="protein sequence ID" value="VDM24463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000423801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000423801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000423801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273819at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000423801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26903" checksum="3C117F6C63F377C5" modified="2016-01-20" version="1">MGGFRLRNSLLSTGSRASIKYDPVLDVTSPEYYSAQFSQLQSSSEVEGLRGQLGVCEKRRVDLERRVAELSSTLSQAQAANRANEAALTASRRNEAALRRRLLATMDTGSTSSQRSRPISSLDYSETTTSGLKDDMDMIKLEAVNVALSEASQLDRVRLQEQATRIAQLEAEQRTLHDRMASLQASESCAQRASVRLQALYEDMLREFSESTTHEAHLAASRRRQRQADLRGYETDTAVHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUW5</accession>
    <name>A0A0R3WUW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4541</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004712">
        <property type="protein sequence ID" value="VDM25146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WUW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000455501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000455501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000455501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="10">
        <location>
            <begin position="92"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000455501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28042" checksum="C42F33CD5480DC37" modified="2016-01-20" version="1">MTLEPEISREIVATPEGWSKPASGHNYVRVTFDRTPVMSTYLVAMVVGDFEYISSKSPCGGTTWTEESAKAQGGQLEIRVYTPLGKRKYGEYALGVAEKALPFYAELFGCPYPLPKLDLIALPDFACGAMENWGLVTYRETSLLLDPKNSSLSSKKLVALTVAHEVSHMWFGNLVTMSWWTDLWLNEGFAMWAESLAVDHCFPEYDIWVSGPTQCGRVRGAIESDCRKCGLRIVGMGMSGGWMDGRIDGWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVD1</accession>
    <name>A0A0R3WVD1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4705</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005140">
        <property type="protein sequence ID" value="VDM25492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVD1"/>
    <dbReference type="WBParaSite" id="TTAC_0000472101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000472101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000472101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000472101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11709" checksum="D1379DDADE9562D3" modified="2016-01-20" version="1">MESRFHALGDFLFCFAASKAWCLRMELSLFRWEGEEEVEEEEEEEDDNTGSKGGQLPEVRRRGMGARGVLLREAEEAGRGGREEDAGDTLDVEVGWGVLLVGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX44</accession>
    <name>A0A0R3WX44_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5321</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007023">
        <property type="protein sequence ID" value="VDM26686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX44"/>
    <dbReference type="STRING" id="6205.A0A0R3WX44"/>
    <dbReference type="WBParaSite" id="TTAC_0000533401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000533401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000533401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000533401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17908" checksum="D56D39E0A53FAF4D" modified="2016-01-20" version="1">MVSSGRSTPGISHLSASRHGIVIDPELTLPQHAQLHAVDPYAVNMTWQPPAKPYNPLTGYTIEWMLEDYWQERLLPPSRLFYTSSRLTPGQSISAAVRAHNLPNTSMIFDYIAEKKTSSEEHGQWCRLSSPLPTERMLGGGKGDCALSMGNVTWWVNVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXH0</accession>
    <name>A0A0R3WXH0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZNF711</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5445</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007545">
        <property type="protein sequence ID" value="VDM27013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXH0"/>
    <dbReference type="WBParaSite" id="TTAC_0000546001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000546001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000546001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000546001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5517" checksum="D3159081EEBDDE71" modified="2016-01-20" version="1">MEAAVEEGDGAANVLMEISEEDLVPVDGKPEGETEVTESSHDARGREMAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXS6</accession>
    <name>A0A0R3WXS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5551</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007958">
        <property type="protein sequence ID" value="VDM27211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXS6"/>
    <dbReference type="STRING" id="6205.A0A0R3WXS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000556601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000556601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000556601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253962at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000556601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21335" checksum="94910D5A55C18777" modified="2016-01-20" version="1">MIKRHVNRNDLVSELKWSIEDVTKIPVALQALSYGSWLLEDSVRLGDYNIRRGSVVHVLRRPNPAPISEVGSQSPQCRTLARDEVDSRADSGFGDLLVVKPSPLKRLPVSKVPESVPILDEPVPVSAKEEDEEKEKVEEPDPTPKVTTPPSEPKVEKGESLRLNLPETEVYRNFRQALSDRMVAQKEKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXZ4</accession>
    <name>A0A0R3WXZ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RPN7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5617</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008243">
        <property type="protein sequence ID" value="VDM27333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXZ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXZ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000563401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000563401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000563401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit Rpn7 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000563401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12109" checksum="254143990F365D1A" modified="2016-01-20" version="1">MKYYTRSREYCTSWQQDLNSCLSIVKVSIYQAAWSHAGAYVSMAENFCEAQNSESPKNGDARPISPAVAAARSELALASGLIKLVTCNYQDATAQFLQVIVCLISKDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY50</accession>
    <name>A0A0R3WY50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SERPIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5675</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008523">
        <property type="protein sequence ID" value="VDM27424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY50"/>
    <dbReference type="WBParaSite" id="TTAC_0000569001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000569001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000569001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000569001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8483" checksum="A0AB2EC499925A0B" modified="2016-01-20" version="1">MLTKVFTVSAHPDLVETDARRTLMSAATIRGEAFFLMPTPYLLPAMCLLSAAAAAAACGDDDDAMLTSAKVGNFEVGFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY56</accession>
    <name>A0A0R3WY56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5681</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008553">
        <property type="protein sequence ID" value="VDM27433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY56"/>
    <dbReference type="STRING" id="6205.A0A0R3WY56"/>
    <dbReference type="WBParaSite" id="TTAC_0000569601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000569601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000569601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000569601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11059" checksum="179828E42325AA6D" modified="2016-01-20" version="1">MCLLWWWIWCRPQEVSIVGCHVLITGGSSGIGLALAGEALRRGPARLTLVARDVNRLEKARATLIEAYGTACDLRTISLDITAPYEEIKQSLLVTHNGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYQ2</accession>
    <name>A0A0R3WYQ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5877</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009501">
        <property type="protein sequence ID" value="VDM27866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYQ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000589201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000589201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000589201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000589201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10029" checksum="1CFEDE93246FEE08" modified="2016-01-20" version="1">MDVEQVAAIVGDKVALLVDSDESAIEHAEVTFAERNTQLTLEIDALKEKLTTLEIVAGCLQYLAPAPGNPLDGFADAICGPGASFLFYFVVMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ26</accession>
    <name>A0A0R3WZ26_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6001</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010156">
        <property type="protein sequence ID" value="VDM28162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ26"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ26"/>
    <dbReference type="WBParaSite" id="TTAC_0000601601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000601601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000601601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000601601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8123" checksum="44F3B37108AF5769" modified="2016-01-20" version="1">MEVDRENPAFVLLPESPPQLTEDKEVERTQFELDQSESPETSLRLLSLDPLKPSSHEDEDDSHENLQVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ93</accession>
    <name>A0A0R3WZ93_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein tyrosine phosphatase type IVA 3</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-tyrosine phosphatase 4a3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS6082</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ93"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ93"/>
    <dbReference type="WBParaSite" id="TTAC_0000609701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000609701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000609701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000105">
        <property type="entry name" value="Protein tyrosine phosphatase type IVA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="84"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM30229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000609701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21025" checksum="715A3971DACADF71" modified="2016-01-20" version="1">MVSRQLLKPVITDVMYKGMHFIIMDSPAADTVQTFAKECSRLRVSDVIRVCEDKYPIEPFEKVGIKVHHWEFEDGSFPPDDILEKWFELLRLRFYGPKKTPSGDGSGNENSHPGSVAVHCLAGYGRAPVLVAVALMELGMSNHDAIELIRSKRKGAFNDRQVESLRNYRAKNRLRKNLHQCWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZA1</accession>
    <name>A0A0R3WZA1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6092</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZA1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000610701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000610701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000610701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000610701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19491" checksum="193EA2BEDD615C3E" modified="2016-01-20" version="1">MPSEMTSIVLMGPAGCGKSTIGSLLRSKLHGCFIEGDTFHSIHNISKMSSGVPLTDDDRQPWLERIHSEIVKARLSSQSTPIIVACSALKRRYRRVLARPPNADTLFVLLDAPADILEARIRQRSDHFLPPSMLQSQLETLEVPLTGVENFLIVDATLHPDEVVARILAGLKAADSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZR6</accession>
    <name>A0A0R3WZR6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unkown protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6292</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZR6"/>
    <dbReference type="WBParaSite" id="TTAC_0000630701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000630701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000630701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6067390at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000630701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11328" checksum="557E73AC646F6CF5" modified="2016-01-20" version="1">MLLPYVKKLETYMKSGTRHPLYPWSVASRLRQFPYAWYYQNNKFVRYYVLSMSVFLPFSVYLLIKFHYVKKKLTHNYDPFDPNEIPASKLGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X052</accession>
    <name>A0A0R3X052_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X052"/>
    <dbReference type="WBParaSite" id="TTAC_0000647601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000647601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000647601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277684at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000647601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42513" checksum="D7AE4B4A92D7D1AF" modified="2016-01-20" version="1">MPKSIVLKMRNHLQRAFAWLVGRSQSGPVSAEALHRAVQIHFCAELFNSQMPSVHKEKKKKDNKKGKSAEEPEICLFQIPTFKPKAFKSKDELDDLKNGKPMDIKLFKDGVHFYAQGKKKVKHEIPYNELQDIEFVDGSPELVRLIVNSKGKTTCYQVIVADDVNREKMCEFLREKKGKEHHVSSMGKTEQTVEEPSQSEHKPPPPKNMGFAASDFSKNMSSEMSYNDNTNVHYDPPNKYKSMGLKSGFKSSNMSRNSEAAFDRRSRSTAFNVDYRQEEDDFNSIADQFAQSVHQGYAPSRRYETSSYARSRISYEPDYVDDDYDEQTSGYVYDDSEDSDETIVVRPVKPRSLTFYTPFLKVPRNRGPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X070</accession>
    <name>A0A0R3X070_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6480</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X070"/>
    <dbReference type="STRING" id="6205.A0A0R3X070"/>
    <dbReference type="WBParaSite" id="TTAC_0000649501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000649501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000649501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="32"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="395"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000649501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="73683" checksum="B12384A8EF7C0678" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0F4</accession>
    <name>A0A0R3X0F4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6595</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0F4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0F4"/>
    <dbReference type="WBParaSite" id="TTAC_0000661001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000661001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000661001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000661001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="47736" checksum="186A79C0AF6EC999" modified="2016-01-20" version="1">MANRAGDMGMDVQVNRRLNSRYDPDTEKEVIQWVNQLTGENVPLGRENVAAALKNGQILIKQAGEQSVRRHEPTPTHSHEEEAPIQSQHNGGAIQAGQSPFQAFDDMENIQIFLTAAEAYGVPRTSLFQTVDLFEMRNMAQVLSCLLQLGTECQRNNFSGPTCGPKPTYENKREFTEDQLAASKAIIGLQAGSNKGASQKGMSMGAVRHIADIKADDLSKEGQGIIGLQAGSNKGASQSGMAMGAVRHIADMKIGEMSDAGKTSLNLQTGTNKGASQSGMAMGAMRHIADQKIAEMTAEGKSTIGLLAGSNKGASQSGMSMGSVRHVADLKVDQMSKEGQSVIGLQAGSNKGASQSGMAMGAMRHVADIKVDEMTKEGQGVIGLQAGTNQFANQSGMSMGARRHIADIKVGDMSKDSAGIIGLQSGSNQGASQAGMSFGAQRHITDVKVGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N7</accession>
    <name>A0A0R3X0N7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bravo_FIGEY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6697</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0N7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0N7"/>
    <dbReference type="WBParaSite" id="TTAC_0000671201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000671201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000671201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000671201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="841" mass="94611" checksum="0EE9333F125A67EF" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0X5</accession>
    <name>A0A0R3X0X5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6799</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020323">
        <property type="protein sequence ID" value="VDM31068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0X5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0X5"/>
    <dbReference type="WBParaSite" id="TTAC_0000681401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000681401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000681401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31068.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000681401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19692" checksum="DD945FEEBACFFCCC" modified="2016-01-20" version="1">MPLLRGGRYAVTRTKKYLDAGRIIFRENIKVMIINTLSQGKISEGAREFIRWHLPPLQYKNPDVQIVTFRDICPTPFIKFYLSDGRELDVDCSFHTADSIQDHIAAVYAKTYETIKREEVENQKIVNPANFGAKYPRQCICEVYGQVPCSSQQGRPRPWEGQEPNLPPMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X123</accession>
    <name>A0A0R3X123_HYDTA</name>
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        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
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    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0000686801"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000686801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7573" checksum="5F6B36602D7A1936" modified="2016-01-20" version="1">MLPKEVYQSLIIKSSGSATRLIRLLMKSFFSQEELAASSLSGEGIYKQRLQPEITEAIKGKQGEEAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1B1</accession>
    <name>A0A0R3X1B1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Axin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6959</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="gene ID" value="TTAC_0000697401"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="143"/>
        </location>
    </feature>
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            <end position="983"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000697401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="983" mass="106199" checksum="AE6E16450677CA1D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1M8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7113</name>
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    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3X1M8"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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    <feature type="repeat" description="WD" evidence="3">
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    </feature>
    <feature type="repeat" description="WD" evidence="3">
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39323" checksum="B276D2CCD74BDC21" modified="2016-01-20" version="1">MFLSQFSFITGSYDRTCKIWDAATGEEVRTLNGHTNVVYTVAFNLPISGITFIYLINCAIYVFLTILNDFLFPDPLCSKAMGYFFSDRIATGSFDKSVKLWNSESGECLHSLEGHSAEVVCLHFSCDSKFLATGSMDTTAKVWDLETGVETATLHGHTAEVITLNFVGRDDRLLLTGSFDHSAALWDYRTGRRVRHLTGHVAEVASAACSFDGRNVVTASMDKTLRVRVELAVLHGHEDEVLDVAFDLSGRQLASASADGTAILWSISQGNGAYEFKRLKGHEGEVSKVRFTVCFSPRGSTLLTASADKSVRLWDTLTGELRDVLVGHNDEVFSCAFNYDGDTVITGSKDNTCRIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X262</accession>
    <name>A0A0R3X262_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Extended synaptotagmin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS7340</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020364">
        <property type="protein sequence ID" value="VDM31706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X262"/>
    <dbReference type="STRING" id="6205.A0A0R3X262"/>
    <dbReference type="WBParaSite" id="TTAC_0000735501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000735501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000735501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000025">
        <property type="entry name" value="Extended synaptotagmin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="224"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="379"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="642"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="561"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM31706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000735501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="768" mass="85955" checksum="A18A032CA0BBE5E3" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2R6</accession>
    <name>A0A0R3X2R6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-catenin-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7587</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020386">
        <property type="protein sequence ID" value="VDM31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2R6"/>
    <dbReference type="STRING" id="6205.A0A0R3X2R6"/>
    <dbReference type="WBParaSite" id="TTAC_0000760201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000760201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000760201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="11">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000760201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="622" mass="68631" checksum="0AFD73A558FFD0F5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X399</accession>
    <name>A0A0R3X399_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CASPASE_P20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7796</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020405">
        <property type="protein sequence ID" value="VDM32254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X399"/>
    <dbReference type="STRING" id="6205.A0A0R3X399"/>
    <dbReference type="WBParaSite" id="TTAC_0000781101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000781101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000781101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="4">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000781101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32166" checksum="C268F967A047F16C" modified="2016-01-20" version="1">MLTSIRLDNTVVFDYGSIEVKLLSVLLQNRGGCDKDEKLVEKVFCGLGFLVKVLRNLSSGEMRSELSFIGNKTDHSAYDAFVAVIMTHGGLGELYGVNGDAFPVHQLTLDFTAERCPSLAGKPKLFFIQACRGDEYQFGYALPAAGSTDDVAATNSGPAFSNLLQVGVTQVEGEVAEEAAEDVEEKLPIVAAKLPRKQRLVPNFADFLLSYATLAGFKAQRDPQQGSIYIQTLCHHLELHGRSRSLLDIVTSVHREVSEKVFREAESPNQEGTVFQQTPEVRHTLTRRVQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4H1</accession>
    <name>A0A0R3X4H1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8298</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020480">
        <property type="protein sequence ID" value="VDM32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4H1"/>
    <dbReference type="STRING" id="6205.A0A0R3X4H1"/>
    <dbReference type="WBParaSite" id="TTAC_0000831001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000831001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000831001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000831001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23943" checksum="0D7100BA005F2252" modified="2016-01-20" version="1">MITVVTARFLSLHLHSNQRNAAEGEAWCYCTLPFVLFCAFLHLECLMRASQVNRAWNRATHHPRLFQRLCCSPEWSLPNLDAHFPPPLECRNANFFFPNLPSPSDTTTMSNVTADVATAAVVSTTSSSSSGSDSGNSIGSKNNNIGTVSSDGVDWFQKFKWRYQVRKNWARGKHRIRRFVGHTGGKWRHHSLLPISILIRCCALVIDLLIKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X547</accession>
    <name>A0A0R3X547_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8556</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020532">
        <property type="protein sequence ID" value="VDM33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X547"/>
    <dbReference type="STRING" id="6205.A0A0R3X547"/>
    <dbReference type="WBParaSite" id="TTAC_0000857101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000857101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000857101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000857101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51132" checksum="7C668A09E5EF9E89" modified="2016-01-20" version="1">MAVGSVCRFDLEEVVEFIKKNGYSRVGLQFPSDLLPSSIDVYEELSERTSAAIAILGDTPFSSCCLDATAGKRWGVEAVIHFGNACLTESVGGIGAYYVFGDIPCPSIDENLAEVGNQMVKYLSWCGGPVLFFYDFRYRRTAKKMADHLALEGIDLVLSEPALPNRGLATDPSFFKHAGRIFRYDKSRPPRCLLYLGECDWVFYSILVSLREAYAINVATIDPLTGRFALAPKSAAFFLRRRYFLMEKVKSAKRIGILVGTFSVPRYLDILARLKCLLRRANKPYTTVFVGRINEPKLMNLPDLDAFVLVACPQASFYDDSNLLVPVVTPFELECVLHDLAGGEASADHPRRWNGLWLPLDFAADILNSESPMFASEDSVVPAKDPEKSVEKEVEEGLKRDALVVRDDANWGLTLAFQDLLSSTRDSWRGLDPALGQTPPLTTIQRGRAGLPTKYSTFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X553</accession>
    <name>A0A0R3X553_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8562</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020533">
        <property type="protein sequence ID" value="VDM33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X553"/>
    <dbReference type="WBParaSite" id="TTAC_0000857701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000857701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000857701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249053at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000857701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22378" checksum="86FC4472F3FC25FD" modified="2016-01-20" version="1">MFVDLVENNYADAVDSLQKALSFLDKAKSELDIESDELRILEMRQESLYRQFDSLRPYQFLLTHRSIAKSITTRSQGINSCPSKSADPALHVDENNGAHDPLPGRAGATLKLCPKRNDQKLEECEVRINELEKMLEESERRAALEEDARLVAERELLMLQRSHRWCSTSPLTDSVCNTMVTSHNSCAPELVDSNVSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5E1</accession>
    <name>A0A0R3X5E1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS8665</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020559">
        <property type="protein sequence ID" value="VDM33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5E1"/>
    <dbReference type="STRING" id="6205.A0A0R3X5E1"/>
    <dbReference type="WBParaSite" id="TTAC_0000868001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000868001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000868001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12375">
        <property type="entry name" value="RRM1_Hu_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="793"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="803"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000868001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="829" mass="88605" checksum="21490AB32E9EE241" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5H6</accession>
    <name>A0A0R3X5H6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8704</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020566">
        <property type="protein sequence ID" value="VDM33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5H6"/>
    <dbReference type="WBParaSite" id="TTAC_0000871901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000871901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000871901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000871901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32969" checksum="B482CF9D7B546B79" modified="2016-06-08" version="2">MEQAVLPPETRQCPAEVVTKRLQQAYSPLTSNSDCQHQRRLLQEVGGVVRFLQLLCDEGWSAGLSKLVAGRRKKYDATSNDMAWHGMARLDMVVCDSHCGHLSSVISRHIITASQESRHRQQNEAKLSQPPLTERMWVAIDIRCECLAPNALCKPLQKEGRGETDSQVGNARVTVMITSTRASVHIAISYAYIPTFLPAGFYVEEAIDLDSTVFPPYANLEFFIGRYRVMKSVSFPGGGDSSETDLSNRLTIFILSEEEKQKRNKKKKKKEEEEEEGEGEEEEEEEVDINTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5P4</accession>
    <name>A0A0R3X5P4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8786</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020587">
        <property type="protein sequence ID" value="VDM33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5P4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5P4"/>
    <dbReference type="WBParaSite" id="TTAC_0000880101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000880101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000880101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17095">
        <property type="entry name" value="FERM_F0_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="507"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000880101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="841" mass="94140" checksum="E549AA531E266B55" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X640</accession>
    <name>A0A0R3X640_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8944</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020633">
        <property type="protein sequence ID" value="VDM33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X640"/>
    <dbReference type="STRING" id="6205.A0A0R3X640"/>
    <dbReference type="WBParaSite" id="TTAC_0000895901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000895901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000895901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01241">
        <property type="entry name" value="PH_PKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000027">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039026">
        <property type="entry name" value="PH_PKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF407">
        <property type="entry name" value="RAC SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000895901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22446" checksum="9B94C0161CF06250" modified="2016-01-20" version="1">MKRGEHIKTWRRRYFILREDGTFYGYKSIPRQPLNNFTVRDCQIICLNKPKPYTILMRGLQWTTVVERLFFVEHEAERDEWISAIQMVANRLRSENEAPTSVFKVDFADDVVIDFPQRWYQILIFRPPKRYSTDDFELLKVLGKGTFGKVVLCKEKESGCFYAMKILKKTVLIEVIFLVLYTFCRFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X679</accession>
    <name>A0A0R3X679_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Adenosine kinase</fullName>
            <shortName evidence="10">AK</shortName>
            <ecNumber evidence="3 10">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8988</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="UYWX01020647">
        <property type="protein sequence ID" value="VDM33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X679"/>
    <dbReference type="STRING" id="6205.A0A0R3X679"/>
    <dbReference type="WBParaSite" id="TTAC_0000900301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000900301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000900301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="54"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000900301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="37852" checksum="563F20B333E354CC" modified="2016-01-20" version="1">MPCWRDDMGGICGVQPIRLMALGHPLLDIQANVCETFLSKYGVEANGATLKGPKQEGLYEELLQENHKLTFIPGGAAQNTVKMIQWIHQDSKKIQCTYIGCIGADTTGEILIKSMRETGVKSLYEATDKLGTGVCFVLINGPNRSLITSLGAAAALSTNFLRQKRTWEMGYLVVSSMDIVRLILDHASSNGKVLCLNLASPYVARSYTEALDTVIPHADFIFGSVDEAKAYAEARKLDDRSAAGAAKYLISLPRANDICCPRLVVLTQGPGPIYTMSSRDKVLRTFPVTPLPPEDIVDTNGAGDAFAAGFLASYLIEEDLEKAIDGGKKAAKYIIKRSGFSLGSRTEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6E1</accession>
    <name>A0A0R3X6E1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9054</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020667">
        <property type="protein sequence ID" value="VDM33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6E1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6E1"/>
    <dbReference type="WBParaSite" id="TTAC_0000906901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000906901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000906901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000906901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31700" checksum="6ED36BC8B3BB14F4" modified="2016-06-08" version="2">MADKTSLLKWSPDFDSAVGYYSKAAVIYRNAGMLQESAGIYMQIADIHAKNKSFFHCAKAYETASLLFRDLGNFDKVVECIETAGKILRQNGIPDSASTLYAKSAKGLEGNMPEKSAQFYECAADTSELEEKYLQAADFAGQSARLWTRLRHFKEADRLLRYQMRLCSLGASGENVHTAYQVCGKAVVGLVVVKLVLEDSCAAENVYREAVEQYHFNETDDAAAVAKLLQAYEPYDSAAMAEAISLPTFRNLETDFARLARSIKAPESFGDQALPSTPVNEESEDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X722</accession>
    <name>A0A0R3X722_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9319</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020760">
        <property type="protein sequence ID" value="VDM34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X722"/>
    <dbReference type="STRING" id="6205.A0A0R3X722"/>
    <dbReference type="WBParaSite" id="TTAC_0000933401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000933401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000933401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278752at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000933401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72454" checksum="D551220F961221FC" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7C1</accession>
    <name>A0A0R3X7C1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS9431</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020815">
        <property type="protein sequence ID" value="VDM34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7C1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7C1"/>
    <dbReference type="WBParaSite" id="TTAC_0000944601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000944601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000944601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15034">
        <property type="entry name" value="7tmF_FZD1_2_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF47">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133298" evidence="12">
        <location>
            <begin position="19"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="13">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="150"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000944601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="614" mass="68181" checksum="24F3F0F4A06AF31F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7W7</accession>
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        <submittedName>
            <fullName evidence="5">DUF5745 domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">TTAC_LOCUS9627</name>
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    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM34502.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000964201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60649" checksum="3F8F93AFF3B3BC8D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8A7</accession>
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        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TTAC_LOCUS9767</name>
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    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
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        </location>
    </feature>
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        <location>
            <begin position="160"/>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="32"/>
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        </location>
    </feature>
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    </feature>
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            <dbReference type="EMBL" id="VDM34689.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000978201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51786" checksum="BA8B7B2AF7EDF65E" modified="2016-01-20" version="1">MLLSTPYMSVTGARDQTLPPGVLASAWKVMGKHLPRQSKPRQTYQKKNRREQNSLHPVRSPILPSYQHEQRDPGVYLNPPHNEFDRAAYSAFMEETVLPRTTIPTDVPASTKLLPTNVSMFPLVLGVLVGLAVLILLILLLIALGFRTRRQRAAYARRKALSDQANTETTLSETDKVQQQQQQQQQQQHQSAPSLTQQASSANSYGYQQSSDSGAGGGIASTYLPHTMFAAETCWPAGLQPVPQGSNYFNEETPGVAFPPLARDSGSHGYVQLPVSNSHNSGLVYSHQSSTTTMNRSANHLLPYSVPHTCVPTESFSVAPRMCSPAVNSSLSTESDRFSGQASSHPSSFQPLYPSSGAAHISPPSLRRQNQLHTTHPQQQLWVGYDESPVTSAEASNPLLMTQGVEDLQVAVSASFESLIEPPESFKNHPKSTELLMDTVPPRMAQLRRLEKSYEGNQSWKWRDGQFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Q5</accession>
    <name>A0A0R3X8Q5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimethylguanosine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9915</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
        </lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM34888.1"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="VDM34888.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000993001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="801" mass="88061" checksum="2D932C1595E83357" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8W1</accession>
    <name>A0A0R3X8W1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">TTAC_LOCUS9971</name>
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    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
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            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021203">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000998601"/>
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        <property type="term" value="F:syntaxin binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NSF_attach"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000998601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33179" checksum="1DF5044F4A3EC8B6" modified="2016-01-20" version="1">MDENERKAHEYLASAAKHPKGGFFRSIFSGGSDGTEERIALYERAANCFKMAHKWQEAGDAFVQAAELSSSNKSQLDAATHYVNASVAYRKSVPDRAITCLTRAADIYIEMGRFTIAAKHHMTIGDIYEQELANEAEACKHYERAADFYKGEDSTSSARKCMLKVAHYYATSGQFEKAARIFEEAGVSSMESKLLRYGAKEYLMKAVICDMNYDIVKGHNTLEKFEQDYPMFSDSRECTLLKASSKVDEALSSENLETFTAAVKEYDSVTRLEPWMTEMLLKLKKILNNEEDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H5</accession>
    <name>A0A0R3X9H5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10185</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021400">
        <property type="protein sequence ID" value="VDM35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X9H5"/>
    <dbReference type="WBParaSite" id="TTAC_0001020001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="194"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="54777" checksum="EF5A9D8AC5C601CB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9R7</accession>
    <name>A0A0R3X9R7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10277</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021500">
        <property type="protein sequence ID" value="VDM35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9R7"/>
    <dbReference type="STRING" id="6205.A0A0R3X9R7"/>
    <dbReference type="WBParaSite" id="TTAC_0001029201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001029201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001029201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001029201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="33817" checksum="18F3FB574001A73D" modified="2016-01-20" version="1">MQGETDCGVGLDGVWYVVDAVGGKVEVSCGFVASLYSADCASLEDSLRFAAEGTSLRLAYQDTSKDKTAASKMDPQRSEQYERLGMSAGVGGARTKVIGHSAVSDMKTIESEDANDLRGPGGRKGNQSGMGTFEETIDTFSRGGSNWLYLSSSRDGDASDDWDLDPFKARAAAGLSSSSSRTGLLDLPTESRTSRSGNIGVSKSSNSTFSSASTEPPPMSEEMRLKLQNAKSISSADFASEDQGSNFDSSQFEGRTSLSSDEYFGRPQPKYRPDYSVELNSIKEGVREGVTKVATRLSAFANDVMSQLQVILLFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9S6</accession>
    <name>A0A0R3X9S6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10286</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021506">
        <property type="protein sequence ID" value="VDM35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9S6"/>
    <dbReference type="WBParaSite" id="TTAC_0001030101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001030101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001030101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001030101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="9643" checksum="19A3FAE23810F166" modified="2016-01-20" version="1">MAIHNHCCRQDTVVYTCADATRWQPGVPTQAPLACTIKWGAGVEVTEDGDPISSPDERNAGGGGGGGGGDGGGGVDKRSSVFSQLHSAWLECLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA19</accession>
    <name>A0A0R3XA19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10379</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021620">
        <property type="protein sequence ID" value="VDM35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA19"/>
    <dbReference type="STRING" id="6205.A0A0R3XA19"/>
    <dbReference type="WBParaSite" id="TTAC_0001039601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001039601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001039601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248953at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001039601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23112" checksum="69D1C19B0A417BE4" modified="2016-01-20" version="1">MAPSNENRNYANRFHRSLWCPVHGPPMQDCLNNLPVATVAFTSSGNIYELDDLVRILPCHHFFHKNCIDTWLRQADNCPTCRGDVRSLYKDLVKMTALGGPTDNQWEEMELLSEALGTCTTLSRCHSAQGMYEQYFGTSADDSSLQGSVYVPDLGNLSLSDSEQMQGSSRGRSTTARNQGYPTDPVRRHAVQAAERRRNNQLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAJ9</accession>
    <name>A0A0R3XAJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10559</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021857">
        <property type="protein sequence ID" value="VDM35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAJ9"/>
    <dbReference type="STRING" id="6205.A0A0R3XAJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0001057601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001057601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001057601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001057601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12754" checksum="B4A94D8B05F8738A" modified="2016-01-20" version="1">MAIISNSNRTEIDGDFIANIFDFVEQLDSPVSAGSRGLHVFLTGIDDEERQNQRERLFTVDDAALKRVAQTLRDHLVCAKRVGRAVLGPKSAELVEKKKDQDKEWSVVDLSQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAL0</accession>
    <name>A0A0R3XAL0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021878">
        <property type="protein sequence ID" value="VDM35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAL0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAL0"/>
    <dbReference type="WBParaSite" id="TTAC_0001058701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001058701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001058701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001058701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18613" checksum="631D4673EC4E9965" modified="2016-01-20" version="1">MAQPTGSRVTIAYTTTSGIVEAFEVGLDNGTLHKLLFSLQLEVENPTTKTVAPCAANSVAILPDHIAVTGDDGSLRLANLQGVWITKAIRHFAAAVKVISLPKQNCLLTLGADHRLLLWQVGEGGEVFVLSETTLTGLGDPQNMSLLPTNKAEKAYLVMVCGSGLQLCYFKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAQ8</accession>
    <name>A0A0R3XAQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">THO complex subunit 7 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10618</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021947">
        <property type="protein sequence ID" value="VDM35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3XAQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0001063501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001063501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001063501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001063501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25776" checksum="D0B14A630A8FDE2D" modified="2016-01-20" version="1">MANVGATSEDAIIRRKLLVEGESGLDDRRFGVLLKEYLHWVTSDDTPEASDAACQTILEKIFQCENAMEQALLIQLMNMEQSSRYSELLEEIGKYAFTQDKQLDKSIEAARIDITNQRERLKEARVIRKNRQEYHNLAKIVQEYPERQESLRKLQKMRIELNNLESINRMYDDRIDLRKKQFHLFLVALRDLQKLVDQDDPITDPDDQKNVNIDDAMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB66</accession>
    <name>A0A0R3XB66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAV2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10776</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022228">
        <property type="protein sequence ID" value="VDM35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB66"/>
    <dbReference type="STRING" id="6205.A0A0R3XB66"/>
    <dbReference type="WBParaSite" id="TTAC_0001079301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001079301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001079301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001079301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="21846" checksum="645C8B0E35ECDDEC" modified="2016-01-20" version="1">MEGQHRIEQLLNQNRNLSEGFQEMALRLKRLENLSPIPPSTPVSKISNGMTKATLQNAASPRTSTHLPQSSTYSISKSEGFSRLAELDAMVQKMLSPGLGHESLRKTSSSRHTAQRQLSLSGSPKLPSLSPLQSGRSAVANGGTRLSGTENSSSPGGSNSLGLPPPLQMPYRSSGGEDGFLELANRSSVPNEEKVSEPEIELQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB75</accession>
    <name>A0A0R3XB75_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10785</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01022239">
        <property type="protein sequence ID" value="VDM35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB75"/>
    <dbReference type="STRING" id="6205.A0A0R3XB75"/>
    <dbReference type="WBParaSite" id="TTAC_0001080201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001080201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001080201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001080201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="53765" checksum="964B1E02AC53417F" modified="2016-01-20" version="1">MRSFDFVRPKLYPLLQEELALFHTPEHIDRYCPESSSEYEGDEMKMEALGSMTELAMDPETSVNKGDRKLATSSLATLHCGGVGVDSDTVWNPETTSKSARLAVGQVLCLAHNLACGRLRNGFALVHPPGHHAEPDQAMGFCYFNSVAIAALSILRSGQANRVLIIDWDIHHGNGTQFAAEKHPGLLYISLHRYDQGTFFPGTGSFQRHCHSGYIINIPWGCTDASPAASVRRESWRLAKVTKAASSNDSGVPEDCASTMVGGIAQSSTSSPASSSAGSLDAGLARCPVSGGSGGETSGTVGLSDSEYLAAFRSLVLPLATEFSPDVVLVSAGFDAAAGHGSALGGYEISPGAFAWMTRQCMSLAGGRVGLVLEGGYVASVTADCVATCLNALLLPNPPPAVFDVNPGGSSFQRLAILDDCITAAKAWVAPSELARAPRPEAVKTLVEVANVHAASGRWKCLTMPDTSVLVDVALSFNKAMEQERARLLSSSNTAVASSSVWSPSSKPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBJ8</accession>
    <name>A0A0R3XBJ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10908</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022496">
        <property type="protein sequence ID" value="VDM35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBJ8"/>
    <dbReference type="WBParaSite" id="TTAC_0001092501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001092501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001092501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001092501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14150" checksum="B6F6CE1D13D2C132" modified="2016-01-20" version="1">MQRQRRKHRIRIESADVAGGGGGVRLSRGLVKWNTQEVGDSGDKDGEGARVAVGVEEEEEEEEGTSERTDTSPCTQRRMRVWESYTNQRSIPLTNSAHLKLSSSTALLPLLLLIYADLIHSPKYEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC85</accession>
    <name>A0A0R3XC85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11145</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023055">
        <property type="protein sequence ID" value="VDM36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC85"/>
    <dbReference type="STRING" id="6205.A0A0R3XC85"/>
    <dbReference type="WBParaSite" id="TTAC_0001116201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001116201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001116201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001116201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9753" checksum="D413DD0ED355E171" modified="2016-01-20" version="1">MLHNLMVVPADLGLLPSLIRPTPSEVETATTVVQRQVFRRIQLPLDKLLHVQKVTKASFSEISMSLLSGALRAYQQVRTSAYFTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCB3</accession>
    <name>A0A0R3XCB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11174</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023121">
        <property type="protein sequence ID" value="VDM36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCB3"/>
    <dbReference type="STRING" id="6205.A0A0R3XCB3"/>
    <dbReference type="WBParaSite" id="TTAC_0001119001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001119001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001119001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001119001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21563" checksum="5FCF8CDFCC59B267" modified="2016-01-20" version="1">MIAIIILSRDCTSIPTSIAGLEESHTKTLRIDDLESDAIIYSHNFEPGFLTNTSSNLLGQNYYAQYPLAFSCEVVVHAPLDNGRIMLTIESFFIPSSDQTCKDDFLYVFDSNTARSKAMPEAGGEQGLCLSQYPKNPVFSTKSYICIAFHTSNSPRFQVSNSEAIKPGFKIIVTAFQESTSRIPFSFFAFLCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD47</accession>
    <name>A0A0R3XD47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11457</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024272">
        <property type="protein sequence ID" value="VDM36571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD47"/>
    <dbReference type="WBParaSite" id="TTAC_0001147401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001147401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001147401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247867at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133282" evidence="2">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001147401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="48974" checksum="C520FC4E2D428015" modified="2016-01-20" version="1">MVRRIFFFFFFPFLLMTLVGAEPSVIDSLTIQLPSSPDEGGGGGGGASLNSPSKPLFLGLPSVKHFTGRSSNNPECPDITCFTMTLFNGSTIFDCTTEPPRGSSVVHLLDCNYWQPPSTSLIPITAKFFNNGARSVLKAANHAVPLRIVLKPRTTNPNLRIAVDTMVPGALTRLVEAVRRHVRPKFTTPIKLSLIMVKIKRLTYEDLASVFMVANISGLILWNPDYLDETSFLQDADKVAAFSETYVRLTFYCETENDFPAFGRLWLPWLRWQVKFLQCRGHYTCYRWPREERLCCNPKRCPETPGYVVTHADKLAKRDSAASLIHQQQVLDFYSCETESDLTNPLVELKKRENCWAIPGYGDLDTTLRPTEPTSTTTTASTTQSPSTISTENANLLTSTAPISNTNSTAPPHLPLLHPPSGGGSTDHIKMRNLVIGIICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDL5</accession>
    <name>A0A0R3XDL5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025981">
        <property type="protein sequence ID" value="VDM37483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDL5"/>
    <dbReference type="WBParaSite" id="TTAC_0001164201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001164201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001164201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001164201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7480" checksum="A1B79700FC40DA83" modified="2016-01-20" version="1">MYRLVREPPRPLSSGHNDNDNNIYASASEWASAAVSQSSQVAPCNATVVTTTALSTTDASGNCSLSLPPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDH5</accession>
    <name>A0A158RDH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS625</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000068">
        <property type="protein sequence ID" value="VDM16760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000062401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000062401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000062401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17995">
        <property type="entry name" value="DEXHc_CHD6_7_8_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000015">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056342">
        <property type="entry name" value="HTH_CHD6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23078">
        <property type="entry name" value="HTH_CHD6-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1448"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="794"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="942"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1717"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1928"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2120"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2618"/>
            <end position="2643"/>
        </location>
    </feature>
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        <location>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
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            <dbReference type="EMBL" id="VDM16760.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000062401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3186" mass="347630" checksum="329A1B0D13C56C17" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDZ3</accession>
    <name>A0A158RDZ3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate kinase</fullName>
            <ecNumber evidence="4">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6346</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
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        <subcellularLocation>
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    </comment>
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        <text evidence="12">Belongs to the adenylate kinase family.</text>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000636101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20961" checksum="4BDBECA62E5C37D3" modified="2016-06-08" version="1">MFKLLYSSGPGSGKGTQCEKIVAKYGFNHLSSGDLLRAEVQSGSPRGKELQAIMEKGELVSLEIVLALIKDAMLKLIDKSPYFLIDGYPRELEQGTRFERDVAPCFAVLYFEVNEEVMKQRLLKRGETSGRADDNEATIVQRLKTFEEKTAPVIKHYTQKGKVIKVRTIDEVFAVVVQEFEKKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE63</accession>
    <name>A0A158RE63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6679</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020315">
        <property type="protein sequence ID" value="VDM30925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE63"/>
    <dbReference type="WBParaSite" id="TTAC_0000669401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000669401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000669401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
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        <source>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <dbReference type="EMBL" id="VDM33268.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000866201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="753" mass="86626" checksum="5FD3336706BE7A3A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TTAC_LOCUS8731</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <authorList>
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        </citation>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00244">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
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    </feature>
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        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="132"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000874601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27002" checksum="09C65C1DB71745F3" modified="2016-06-08" version="1">MVDSASALSKHNELARVYEVLELYSEMVGEVKAVVQLREAAQEQLSTDERNRLSVAYKHTTSRLRTAWRAAAEILPSARNFTIVGLVRQVRTQLKDEILDRCQEVIQLLENQTVTRDEDGVFLLKMRGDYHRYQAEVDGEKTEHQLQAAKAYAEASTLAKEVLTPVNSVRLGLSLNHSVFLFEIVGDRTAACLLARETLDQALRTIGDADAECQSEITLILQLLRDNLTIWRTEDSTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E9F0</accession>
    <name>A0A3P7E9F0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000328">
        <property type="protein sequence ID" value="VDM18053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E9F0"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="241" mass="27048" checksum="B3B137C1A634665F" modified="2019-02-13" version="1">MPEDISAWYSGHDRYLLESMLIFALRRNFMQAASKIASVMRQGGLQPSSMTLWCLNAQSSRLHNLAKQCCTTSADSELVRILEELSEAAEALVTAVGCESPFRSPLLRYKLDVDKLLMFLYLESPKEDQFPHLDREIQSFRSDYARLLTSAGEAESYIANVWSSNRETAFAVLFADAQVVASHLPYTFFDQVGTRHHELFVQAVKKTQTGFGQVVLSVLADAKEELTESKLTQIADALRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQG6</accession>
    <name>A0A3P7EQG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000559">
        <property type="protein sequence ID" value="VDM18597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQG6"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="168" mass="17600" checksum="D6CDA4FD24504FDE" modified="2019-02-13" version="1">MGTPNCPRLSDVPILEPFAKFGITSDLITDLVFREDSINLAFQQGVILTYSRPMESCSATAAAGDLSIFDTSNLVGDSGAVEIDDEGGIGVGCVETVDNVDVDADDDVEASPPHMRGSTSNASATSSTATTPTNSSNNHRLRHHALSPGLQHRLSRSPFVPESAGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGM1</accession>
    <name>A0A3P7FGM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021320">
        <property type="protein sequence ID" value="VDM35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGM1"/>
    <dbReference type="OrthoDB" id="6252857at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="449" mass="48298" checksum="3EA16EF5FFD6CAE3" modified="2019-02-13" version="1">MAVMSTTTSYGLASDTSVKTFTDAIDTTSTPLVMQTNSGDNESSNSSEDGTELFTLPIEDGDVTEQVPEEVTSDSALVANEHGFTDLSSGEVDTNSVTTEGGLQTLIEEVDGSSTAVSDDSESTIQIGYMEGELGEEEGTTEDVEESQNQGTEERISISQSTNVDDQILTTTTNYVVFNSETGNQDSALEGSGTTSNPDVQNAYESPVDKTETEEYRDKSNHSETPSEVPPSPVTEVDFEEEEIVTIEKKDIDGDFSGDERKIEDNEAHELHVNTTFDALPSNIKPSTATDFITDGSTIEEVQTQPLHAEDVGGNETMKGGVESIGQARAMAEETTETATSTPKADISNSPSSENSTKEETTADSRVATVKLYATNIDKAFQRGSPWFQSLRVHIVESLHGVKSSIYQAATSMEKAVEDLQNVMVSFIDRIHVNSPKGISSDPPNDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FK59</accession>
    <name>A0A3P7FK59_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020458">
        <property type="protein sequence ID" value="VDM32676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FK59"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="466" mass="51705" checksum="F3EB7BBD5EF69486" modified="2019-02-13" version="1">MIQTPTLNKPPRGLTACEEGSISEDVGQFSISSSSGSAEQSSGLPLLPPPPIQAEEFGTLRETAVFAPLRDTTHPLPSGETFDAPTFHFHPSVTTMQCETSALCGYHQPPIQPPQPPQYSPLFFSGYPPYLPTSQSSSQHEVQMSPQRPDVHHPPLHAIGKTVGTDRTQPFESYKGDEEDEEGEGNDGRTTETGRGNGSVGRRKNVTRESTSTLKTWLQGHMNNPYPTKGEKIMLAIITKMTITQVSTWFANARRRLKKENKMTWLTSNRPENENKQNPSSQPSSSNVVTGMTSAKLEQEEEVGESGDEGYGSNLFAFHSAVQPSWISLDPHWQQNYCSGEYDDELSNFFWTMYAKEPFHPQVLSLCVATMKPPVGSETLETGDRRSAHSYEGTQQQSSYTWKDITAVTNSPSTAFPLPSQYTYDEVFHPPHHPLTKQLGMEGQPLPLPTAPGLLEEEVKRRDPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G9U7</accession>
    <name>A0A3P7G9U7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000854">
        <property type="protein sequence ID" value="VDM19252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G9U7"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="387" mass="43406" checksum="CA81822D37B7956A" modified="2019-02-13" version="1">MHTPQAVSRSRSPTVSFMDDPNLRSYYAHPHRSGNHELQRISSASLPDLDSVDNACRVGVHSSTSSGSTLSVSTMGERKICEKICAKTDERGSEWREQDEDKEEDEEDPFIKWASRGMWHHLLYCLCPIEISEWQDLSTPVKIIQIIQAPIFILFRLTIPVVYEDLEPPSNSSPEAAADVIEDEEVTVCSTPHLDGGPNGRMEGEAQLNPPKTANERSEETRSCVVDFEDLHGWCRLLNCFQCLITPMLWVLLITVGGMPLGLYKVGNSNLPVVVIVLLVSTGLTITIFVTSRWDRAPTPYHRPFFATLGFLTSIVWIYAIAHELVNSLEALGIVWEISEAILGITVMAFASSISGRSTFTMLFSHYPPPHSKSNATFKLRHWHVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GA52</accession>
    <name>A0A3P7GA52_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025231">
        <property type="protein sequence ID" value="VDM37137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2115465at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="227" mass="25433" checksum="40723E21B2D1B540" modified="2019-02-13" version="1" fragment="single">MKDSTSVNLNHQXXXXFCSDENNLKDSTSVNLNHQIFEVDGPTIEFAPMGLWMPREFYVKVENTSGVPATMNCELNHFQSQERPPFDIATFPPEHWQAQNARTFEFCRQLLKSKQAFGISIYPSSSAVSLLAHETVTIRLIGCADIFGEFHDTLTISVAPLRNCEVEPQILIARLPVVARAYGSPVEFLTAIKSINTKAFNDCLMSKVTDVRFSELILSSIPARETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GFR0</accession>
    <name>A0A3P7GFR0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BPM/SPOP BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001559">
        <property type="protein sequence ID" value="VDM21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GFR0"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BPM/SPOP BACK" evidence="6">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12383" checksum="0E76A1D3D5824B76" modified="2019-02-13" version="1">MERLKAMCEEELVEHLTVEAACDILSLADIHSAEQLKAHTLDFIMLHAQEVCETEGYERLVRHRPHLLNECFRTIACQQLPLRCPAPGACNSNASSNSNSSSSRKRPRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GPU8</accession>
    <name>A0A3P7GPU8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003361">
        <property type="protein sequence ID" value="VDM23855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GPU8"/>
    <dbReference type="OrthoDB" id="6285173at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="87" mass="8659" checksum="B73603D666CF0250" modified="2019-02-13" version="1">MDALNAATEPPQPRQATSAAPVAGGEHPPPGYDEAVGMAITRSTGGTETGAAAPVLPPRRTAPANNNAAAAESLSLAQRYGLPVAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HG64</accession>
    <name>A0A3P7HG64_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020763">
        <property type="protein sequence ID" value="VDM34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HG64"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="277" mass="31378" checksum="3C344750C4A77116" modified="2019-02-13" version="1">MYDFVVPCRKFYLAKLPCASLEVSAKMDNSEVSNFTSLCDRWWDISGDFRILHAMNPIRIEMINYLFKYESPKPWYPLYGRRILDVGCGGGILSEPLARLGAKVLGIDMLSEAIDAAEDHSLRVNPDRWKDAPFGAPKYRNMSTSEAAAQFSEKFDAIVASEVLEHASDWKNLVRDASTCLKPGGHFIATTINRTIPSYFLGIIVAEKILKITPKGMHEWNKFIEPSELSLVAIRNNLQPRKVLGMAYCPLSKEWHWTRSQAINYAFHAIKVGPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI24</accession>
    <name>A0A0R3WI24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS223</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000014">
        <property type="protein sequence ID" value="VDM16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI24"/>
    <dbReference type="WBParaSite" id="TTAC_0000022201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12778" checksum="A63BCEC249A6AE4D" modified="2016-01-20" version="1">MLLSISRILGRAFAKALQEEYAASKNAARIRADTNKSSSESDFVSSLSGISLEEAKQILNVSDIHNADEVSRKYDYLFNINDKKNGGSLYLQSKVFRAKERIDEELQAKSSSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIV8</accession>
    <name>A0A0R3WIV8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS565</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000056">
        <property type="protein sequence ID" value="VDM16655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIV8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIV8"/>
    <dbReference type="WBParaSite" id="TTAC_0000056401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000056401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000056401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000056401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20949" checksum="DAF75B3F9A64EEDA" modified="2016-01-20" version="1">MAVSATSTRSVVVRGLKAGIRMSFFCQSSIAPKERYHDTGRKEICIREDGIKHSPVTVYLGKRDFIDHLTHVDPVEGVVLVDAEYVKGRKVFIHLLCAFRHGRDGDEFHGIDWHRDLFLNTKQVYPPSGSMDESASHSKISRLQERLIRKLGPDSYPFTFKVEKATSFPSSAATYTSATLSRSFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJH6</accession>
    <name>A0A0R3WJH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000106">
        <property type="protein sequence ID" value="VDM17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000082501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000082501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000082501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000082501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14999" checksum="E11AD4718CB0AAAB" modified="2016-01-20" version="1">MPNQVGSHYPSIHHQSNGTDVSRHCLPHRLHLHAASTFLPSSLPSSLFASLPSITPSRVPLIHLSSPSKSATPHRRMGTCYACISTVVDCAACESDGFNSIEVLTGEEERARLSQWKLLTHTYHIASRRRISCAIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK85</accession>
    <name>A0A0R3WK85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1121</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000188">
        <property type="protein sequence ID" value="VDM17496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK85"/>
    <dbReference type="STRING" id="6205.A0A0R3WK85"/>
    <dbReference type="WBParaSite" id="TTAC_0000112001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000112001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000112001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000112001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37096" checksum="C2630538529C45E8" modified="2016-01-20" version="1">MEPQTTRVKPTETPDQSVQIEGINSSVPPASLETILRRIPMPTVNLPLLATALLQSALAAALSKSALDFLNIATQTVPPVEVPLDLRTMNQPNTPKGQKIPETDEPETAEPLPLLKRQKLMTENEQKPSENVQHPFILINPYFLPVVSVPESEGPLDFSNPTEHHCTYPGCNKTFRYNHALINHYRIHTGEKPYSCDYPGCKQAFARQSNLLTHRMIHLNRAMRKTFACTVPGCEKNFLKKTNLDDHMNLHLNKRPYSCDYPNCGKSFRCRSNLSGHKRVHAREAEKEKANRPSPLERKIDTILAKARASVANQSVAEGERRRGEGRASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKC6</accession>
    <name>A0A0R3WKC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1164</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000200">
        <property type="protein sequence ID" value="VDM17566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKC6"/>
    <dbReference type="STRING" id="6205.A0A0R3WKC6"/>
    <dbReference type="WBParaSite" id="TTAC_0000116301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000116301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000116301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052794">
        <property type="entry name" value="Mito_Ser_Protease_LACTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520:SF1">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="43"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000116301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="484" mass="52572" checksum="4898BB4909B9ACE8" modified="2016-01-20" version="1">MMHRALIAATWGLVTHNVNQSSIKNHNGNGCTYLLRDVVTTADQMVEAYKDIVGAPGVSVSVSIDGNIVYCRGFGFADVEQGVKVTPQTKFRIASISKSFTSLLVGRMVDQGQLNLDADIKTYLPGFSPRTKEGNSVSITMRQLLSHTSGIRHYHKSKDENDDEYTGEMLSTKACDSALDSLAIFQNDALLYRPGEDYLYSTHGFTVVAAVLEAIMSKNYPHYSLFERPDRLKVPTGSGIGKMPEEVKSSSLFKELFKFLSLQNTCLDEPYNIVPFRARPYRRAKKNGRLENSPCVNNSCKWSGGGLLSTTPDLVKMASHLADIYMGRLCDLPQLAVVSRDTLVNCLWHPNRGTIQGLWLPGGLYGLGRSTTPIDKAKDSTHSDRLYVGHTGGAIGFTSILFMSLPIAATSTSDESDDPSSASHLPPICVAILANLENAKGIGQLAIHLTELFTAVLLTPHIWPAAPIITAEGPLSAPPIAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKP1</accession>
    <name>A0A0R3WKP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000247">
        <property type="protein sequence ID" value="VDM17747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000128701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000128701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000128701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229380at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000128701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16624" checksum="68735351629B5ECC" modified="2016-01-20" version="1">MAQKLVEVSRLPVVLLSLAFILSAIAVGTPFWQGKSLFASQNLHWEQLCTAVGALLIIGCIGMGLAFLLGIYWTIYPDTVGPVLLAFYITLYVGAIALSIAVLVFTTMITRTWSFFMAIMACFFAVLVIWVDLPLLSVTPLPWKGRQVPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKY4</accession>
    <name>A0A0R3WKY4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1396</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01000294">
        <property type="protein sequence ID" value="VDM17928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKY4"/>
    <dbReference type="STRING" id="6205.A0A0R3WKY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000140901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000140901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000140901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000021">
        <property type="entry name" value="Deoxycytidylate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM17928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000140901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18141" checksum="3E00CC3F14B2C051" modified="2016-01-20" version="1">MERLMLFRPLQQAKRNDYLQWDEYFMALALLSAMRSKDPVTQVGACIVDNENKIVSVGYNGMPVGLSDDELPWTKRQEDPLQNKNFYVCHAELNAVLNKNTLSVKGCKVYTTLFPCYECAKVMIQSGIREVIYFDEKKTITPSGDASKIMFLKANVKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLX2</accession>
    <name>A0A0R3WLX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000487">
        <property type="protein sequence ID" value="VDM18485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000176001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000176001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000176001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000176001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11567" checksum="EFF2480359EF578C" modified="2016-01-20" version="1">MVVGAAVGAAAAADDDDDAKIEGEILKASQYTFMLGLAAPRGYRFLAVRSVVLDRQVTIIDRQNVSMDDPSALLLGSSACKTLLNRLQQWLEEEEEQQQQQQKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMF1</accession>
    <name>A0A0R3WMF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1926</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000611">
        <property type="protein sequence ID" value="VDM18666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMF1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000193901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000193901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000193901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000193901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41238" checksum="94B824DB031999D1" modified="2016-01-20" version="1">MLALDKVVIVCGHLGSPLQCVSKIMAEDQERAFVATTTQKRVRQIIILHVGSTISAVGILGSLICLFIFFRHRLAVPTTHYLLVASSLIDLFYLSLEAIIHHPPFIVGNRNGTYLGSYISLGVLRSGINLGQLLRNWIIVCLGFERYLLVCHPMYFRTQWKLKHIHILMTVVVITCVTIRTPYVLAYIFDIWGPEWCNASEIAIALHTIFDVIFVALIPVPLLAYLSATIVMKSNRLQAWRVKMISKVDTKQSRIKNVNQKAHQAIMVVVICFTLFTVAFIPNGAFRLLKYSGFGTKCKIHFYRQVTASLVFLGDLLNSSMNFFIYMVYWARFRRAMITTLDTYFLCLKRAVVDRERPRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMM8</accession>
    <name>A0A0R3WMM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2003</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000677">
        <property type="protein sequence ID" value="VDM18743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMM8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000201601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000201601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000201601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000201601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32429" checksum="4725FDB8C9E70C4F" modified="2016-01-20" version="1">MAKVNVCDVEVLDNPSTFFDKFKFRITFECHEPLEDDLEWKVVYVGSAYNSSLDQTLDSILVGPVPVGRHQFVFEVNAPDPKKILPEDLVGVTVVLIQALYHEQEFIRIGYYVNNEYKSEELRNDPPAEPLLSEVMCNPLFLTLQLERSIIASDPRVTRFPIDWGDGLLDGCPEPEQKEEDVDALEVMDSKSEERLDEQEGEDDDEEGIEADFEDVGEEDLGEEDDETEDEDDEDDECEAGAEDPGAVVDENNAGYEPMDTDRTSLKNSPSANLESILRASNSPLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN72</accession>
    <name>A0A0R3WN72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2197</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000841">
        <property type="protein sequence ID" value="VDM19196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN72"/>
    <dbReference type="STRING" id="6205.A0A0R3WN72"/>
    <dbReference type="WBParaSite" id="TTAC_0000221001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000221001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000221001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="105"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM19196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000221001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27301" checksum="4F1C2D8727CE8B49" modified="2016-01-20" version="1">MTAFDMYCNNTNVLTESLFIFLNSFPPGTYLEETLDQPLDLSIKRASDYHDSDSNSNSSNSSDSSYGNEDRVDEESERAEDLRLYNLLRENTSINEMHLKNRNTPVLWQFLLMCLGSRQCNPSLIEWISRETATFKLTNVNALANLWGQIKKRPRMNADHFKRSLRRCYKTALDGAVDGGWHHMAIGELSSICALSEHAMGELLYASLEPLNWVENNTILRFTAKILNRLAAVKQNPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNS3</accession>
    <name>A0A0R3WNS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Tubulin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2398</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001036">
        <property type="protein sequence ID" value="VDM19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNS3"/>
    <dbReference type="STRING" id="6205.A0A0R3WNS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000241101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000241101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000241101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6662575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="486"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="743"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000241101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="925" mass="104512" checksum="CA83522C8B9E94DD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP21</accession>
    <name>A0A0R3WP21_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2496</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001141">
        <property type="protein sequence ID" value="VDM20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP21"/>
    <dbReference type="STRING" id="6205.A0A0R3WP21"/>
    <dbReference type="WBParaSite" id="TTAC_0000250901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000250901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000250901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="238"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000250901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37782" checksum="5E5BEBD43D4E7571" modified="2016-01-20" version="1">MELNDTISQKIWDGSIPVSFCISPSEITHELPPPPPPFLMLVPRVTYFALVLEKAIPQFYIYLQSNSRVSDTHPRSDSNDDSSPAHSAEESHPTRKEVDYWLSYDGVPLKWQEYPTDILLAPPVSRSAVEAVFIATLKEADQLKHRGRGGLGPIFDGLLPAEQHRLWNGLLQHRFDVFWSINKRFMLGAPAPIRPLPQSDPLTDSTGDDTENSQTTRIFAEDAAALMVATGAMKAFRHCPFRLYFSPHTFDTSPPTMTYLQTLVSPFSEVDGTPVTFFDVITTLLKCSNVQLRAEDFIFLVHGVEVPSETPAQWMCEWMAYPDNFVHVVACKRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPB5</accession>
    <name>A0A0R3WPB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">REKLES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2591</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001252">
        <property type="protein sequence ID" value="VDM20586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000260501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000260501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000260501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000260501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9334" checksum="BD4DA69782EE29BB" modified="2016-01-20" version="1">MKALCSLSTTTNVLQQPNLLPQQAREAASRLALQSTPPASSLSLLTASASAAVSTSPTSSSSAPHFSSPSLSLCQPVSSSSLPTPTTFLPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPB6</accession>
    <name>A0A0R3WPB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2589</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001251">
        <property type="protein sequence ID" value="VDM20584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000260601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000260601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000260601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000260601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22809" checksum="D3851AC148AA6986" modified="2016-01-20" version="1">MVLDFEATCIGRGRVQCQEIIEFPVLLLEAERCREIDRFHRYVRPIVNPQLSDFCTKLTGIIQDMVDSQPTFPTVMKEFEDWVDSHFSSDEEKSTFALVTCGDWDLRFMLPHQAALSNRQIPSYCRRWVDVKKASLSILSPLAYAEYTGRHVDGIVPMLRCLNLPHEGRLHSGIDDCQNIAKILQFLVAEKATLRYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPE0</accession>
    <name>A0A0R3WPE0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2615</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001288">
        <property type="protein sequence ID" value="VDM20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPE0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPE0"/>
    <dbReference type="WBParaSite" id="TTAC_0000263001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000263001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000263001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979965at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000263001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29091" checksum="7430A88769DBB360" modified="2016-01-20" version="1">MPKSGKKSKESKASKGSQKGSKGSKGSKGSKKVPKTIEPVEEPEIIVPVPEGVMHKRMRFLLESTLKTDVDFIVGPDGNETTIKAHKCMLAAESPMFEKLFADCQEWKDAEVRKREQEVLEIRQREAEVEAELAREATQREPGKVESQKSKSKGKGKGKGSKEKGSEKSKSKDKSKSKGKDSKGSKGKTEKKSKGKEKGSKDSKGKGSKGSKEKGSKKGQQTADEGPVTLINFHKDEVIGPDTIRVQDVHPLGFFRLLRYLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPQ4</accession>
    <name>A0A0R3WPQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2729</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001436">
        <property type="protein sequence ID" value="VDM21005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPQ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPQ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000274401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000274401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000274401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM21005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000274401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="34769" checksum="0CBB4D2D2EFCF398" modified="2016-01-20" version="1">MSVSHSERHNYRASPSWYNSYRNLIHRCADRIRLTNHPIITQLMAETLATIFLIFYGDGAVAQKFFFSSTFLEISVGWGAAVVIGIIVGGKASPAFMNPAVALANAVTASLRWSLLPLYIVLEVVGGFLGAGLLLAVYNENLVQYAKEENDGHYYVNTTGGIFVAGKGSSVGAAVLDQILTTALLLFGLLAVGDDRLVKKSSKFAPLLAGMVVYMAVGTYTANASSALNPARDLGPRILLLASYWGVSAFTIDNYYFWVPALMPLIGAVLGVILYHLLIGLHAPPVGEYSADDDQHTEADMSDKSSYILKKDSTVYDGEDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQJ4</accession>
    <name>A0A0R3WQJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3019</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001810">
        <property type="protein sequence ID" value="VDM21760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000303401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000303401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000303401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047161">
        <property type="entry name" value="GIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097:SF3">
        <property type="entry name" value="ARF GTPASE-ACTIVATING PROTEIN GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000303401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="37006" checksum="1352FD85A63F473B" modified="2016-01-20" version="1">MANTRLQAIAAGANLEGLKIPTQSECSRWGDLCIDVYDEAERRLTNSFLEPTIEAPSPSGPISRPLPPSGGSLSGRPQSMAAVGGISGTTASTTTTARPSSLILFFLPPNTAYTSVRNQARQKLGRLSMTAFRALVVDVLHEAAHRLVPLLESSSTIPLAVVRPKMRHHEYTTYGGSMDGTRVAVDNDDEVLLVVGSGNDGIGGVGHRPTDKTSCISMDDPVYDQVAVDTEVGTVTRASVSTVPSIATTAISTAAGAVSVATSTTSPTLALDVASESLQTDQLQKYQEGSQDHQQLVVSLAEECITSSTPNSVVSPSLLANTSPPSGGIESRPGNLPGSRRLHLAATGRLASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQK5</accession>
    <name>A0A0R3WQK5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS3030</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001823">
        <property type="protein sequence ID" value="VDM21785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQK5"/>
    <dbReference type="SMR" id="A0A0R3WQK5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQK5"/>
    <dbReference type="WBParaSite" id="TTAC_0000304501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000304501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000304501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="15">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM21785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000304501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11367" checksum="A9E5DFD3F8B97598" modified="2016-01-20" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQX1</accession>
    <name>A0A0R3WQX1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001983">
        <property type="protein sequence ID" value="VDM22047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQX1"/>
    <dbReference type="STRING" id="6205.A0A0R3WQX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000316101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000316101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000316101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000316101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14904" checksum="ACF5C968ACD7E4CA" modified="2016-01-20" version="1">MNRPGLIAPLVRPGRCDSAVEEMEAERVKNVLQMTGAERIISNYLPGKLEESGWNAQMFEECCKWLKANTASGQRVYYGQKIREKFREPEDVDPQELVAPLTKMGMSLVPRELSTEVVEHIIKVIKENITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSG7</accession>
    <name>A0A0R3WSG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3692</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002880">
        <property type="protein sequence ID" value="VDM23162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSG7"/>
    <dbReference type="STRING" id="6205.A0A0R3WSG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000370701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000370701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000370701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000370701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42942" checksum="6E6F5D924846CA6C" modified="2016-01-20" version="1">MQSLPANRRRRIDVNGVSLVDLKAEIARRQSEVKARATTVPNVAGAVLKRVVDRNDVGLRLKRSPSPVQNLKGRVGDVEAKETTEEDIDWERARRNLEAKARLYEALKQAAVTHSKGGYGEEDRAPLIDFERKAVEEKRSIVNSSDEDEFDDRNRPCEANPHSTATAKPVSIPEGPVTYAHLRQGEVRDHGTGFYAFSADADQRAAEQAALRELRRRTERARERVEEERARRTVAMGRRLAQLRARKGLPDVATAAASLLEKNTTPPHSSPTSPSTPPLSSEGTVGEQLCSDDLDIASMLRRLRDEAEVKQAAAAAAVVASTVTGPSSKNTSPLPDVLTPLSRKRSTREWDRGKSFVPLPPKSRFSSYKHKLSDERNAEFAPPEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT94</accession>
    <name>A0A0R3WT94_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3969</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003384">
        <property type="protein sequence ID" value="VDM23886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT94"/>
    <dbReference type="STRING" id="6205.A0A0R3WT94"/>
    <dbReference type="WBParaSite" id="TTAC_0000398401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000398401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000398401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6239287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000398401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43551" checksum="B6B584EFBAA34377" modified="2016-01-20" version="1">MFTTEESLETMMLDETLSVVTGEKGGPFGNTNTTTTTLSMLSRVLSPKDANAVPYLVLFFASAVVMLFLLVINTFICLLEHQRKGRSHGIHLKHLHLKDSNNKEFVVISGKKPKHQEGGYIPLNAKVPNYLFKQSEIPRRGFTCAKKGILVTYTSFRVFYTFIFTFSVALSILFSFWPPVGVENMGSASIWNKGILLPLRQREAARRESDTEKLMNQHSAKAAQLVHACQDTLIRQIVDVAREVDRTVQEVLDAELNPQKSKENMFKLLEAFILRYMNDLDLAVQDYISHLRAELDSSMMPDVIRFSELLSSIYASQWLLFVKRMMNSTHIPWDINAPEVQFVPTPEHLNALRLKVSNIEFARQFGLAEAENFLFIPSLITSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUN5</accession>
    <name>A0A0R3WUN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4806 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4460</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004497">
        <property type="protein sequence ID" value="VDM25003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000447501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000447501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000447501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6224101at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133104" evidence="2">
        <location>
            <begin position="29"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000447501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45858" checksum="222782089913A1F1" modified="2016-01-20" version="1">MFIVNRCGRVGAFYALAVLTIVVPEALEDRKPTYPYLRVSDWVYPLDRSCSFIYCWAKNRMIIQEPYSHIWHPRYIVVRLPNLITDQEASVVWNYLDNLAQVKGKFNCAPQPITSSLHNEGLKPIDECKLDNAPPNTDSGDLKVVKPRNTSKTGCEDQPCSLSAVPLSVALRPTKDSRASQKKVETKMPESGRRKGHKIVSSSQTKFEPKTSDPEGNPNKNASHFSRCLKELMEGCVAGSSTKEFIEIIINPRSIKISCYMAVAVRITFNELSIKKSQREMTGMPSPFDFGEASLAASASLIRNHRLRNLISAAEYFDEKLNNKQFIFVQLEPSPKKLTLMRPCKMPHPLTACPVTAKLMCCHPPLDVLLVATVSKRRYLKEMTCLDEFRRYNPHQDPAKADFNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVU2</accession>
    <name>A0A0R3WVU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005526">
        <property type="protein sequence ID" value="VDM25786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVU2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000488201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000488201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000488201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000488201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16022" checksum="CD142E8EF7C49A60" modified="2016-01-20" version="1">MQANVRAWQARKRFIAQQHFIVQLQSFARYWLSRHTLHHMTRGRDFFSAETAIQYDGDTNVYFCESEVPEDVMLRNPLRAKWTSAPTAENPIELVSLATAASEECGTHQLSPFFDTDHPVPTKLPCSETCADLFSFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW82</accession>
    <name>A0A0R3WW82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Folate_rec domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5007</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005938">
        <property type="protein sequence ID" value="VDM26057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW82"/>
    <dbReference type="STRING" id="6205.A0A0R3WW82"/>
    <dbReference type="WBParaSite" id="TTAC_0000502201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000502201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000502201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567542at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF14">
        <property type="entry name" value="FOLATE RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133014" evidence="4">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="36"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000502201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28719" checksum="5A4F3AC0B1D95876" modified="2016-01-20" version="1">MSDFVLVLLICFSVIAVSDAWNRLLYVDTVEKYLDMCPESGHLKEHPSPEPDLDECTEWKDRTCCPRETATLIASATLHGFSFNFCENMSKPCRDFFHYDYCMIKCSPDLGPWIVKLTSSRFKERAFRIPLCESDCNAWYEACKEDKACAINWRSGGFDWSEGTNKCRDGFTCVEISKLYGSAKTFCEHVWDHSYRVVPVESVAVWNSSDKHCMHIPRGGGDPNAPGIVRHNHEVARLFATSIIKRVYGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWC0</accession>
    <name>A0A0R3WWC0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin_tail_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5045</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006055">
        <property type="protein sequence ID" value="VDM26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWC0"/>
    <dbReference type="STRING" id="6205.A0A0R3WWC0"/>
    <dbReference type="WBParaSite" id="TTAC_0000506001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000506001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000506001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000506001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12558" checksum="437627294E068BE2" modified="2016-01-20" version="1">MIFLYPVLLKERMNEVIMLRERAVIAEERMEAQQRETARLYERLAETEKEASRLSRSLSTERFERERLSTELRSVPATYHASGYSGSSGRYTTSRLRSPRREKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWC4</accession>
    <name>A0A0R3WWC4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TSSC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5049</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006071">
        <property type="protein sequence ID" value="VDM26151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWC4"/>
    <dbReference type="WBParaSite" id="TTAC_0000506401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000506401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000506401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000506401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35265" checksum="CB1CB27A9C8EC7E6" modified="2016-01-20" version="1">MIRGFDFSRSMPDTEGSSLNPSVPFVLRGSSSVFSRRQLDTFGSLQALEDAHIKVTKATKAERLLVKKMAWRLVKPAVESLAAEKEARDRRNASSEVSKNPFKVPTLLPPRVSKLRGSGRRTAHQFTEVPRRDPSKWTHYSLADVDEDAGLGANANRKIASDLMRELRRQRDELEGNVNGPPPSSDAALPGRILFRSVSGKKRARLDTSNLLLSSVPTVNSKTLNEDEEEEVLSSSDNRTTFDEQSSTSGTVTFRTRMQRRRQCFGRLSASTLKDSDEEVDKSESVSISSVALEGDNSSDIAAEDSDMDDAAMEDGLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWX6</accession>
    <name>A0A0R3WWX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox protein homothorax</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5251</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006766">
        <property type="protein sequence ID" value="VDM26563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WWX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000526601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000526601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000526601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281941at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000526601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32982" checksum="5E1D8572A162391C" modified="2016-01-20" version="1">MPTESVGRNYERNRENRARRRRFKGTNVESVHEGLTKTPTGLRRSRIDMPTRSAKSLSNLTLIERESGGTQSNTNGAGGGGGLMPISRIIKWYRNLSTTRDSVPPTTQGKVVALDQNPSSPLHQLSSHAGRKQGYTGPLGLGEYVDSMGGGFDETEPPNGSPQAQVKSRSLIDISMSNLWGEEDETGPDGDGDETGRNGSWEKVQRPSISMERKSNLMATISRLLPLPPTPPNLLQFMDSPSTSANIYENTEITFFGSSEDRWSTPAFVVTTCNRMQRGDLFNVSFPETHFCDTFETLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX01</accession>
    <name>A0A0R3WX01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotran_1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5277</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006833">
        <property type="protein sequence ID" value="VDM26605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX01"/>
    <dbReference type="STRING" id="6205.A0A0R3WX01"/>
    <dbReference type="WBParaSite" id="TTAC_0000529101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000529101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000529101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000529101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10440" checksum="C72C5D4F5048B68C" modified="2016-01-20" version="1">MTNTTTKVLNFGSYNYLGFAEPSGPCVEADVKSIEKYGLGVASSRLEVGTLAIHAELEKLVAEFVGQEAAIVFGMGFATNALNMPRIFDKVRYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXM9</accession>
    <name>A0A0R3WXM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5505</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007775">
        <property type="protein sequence ID" value="VDM27116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXM9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000551901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000551901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000551901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000551901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16754" checksum="898770D907554E52" modified="2016-01-20" version="1">MLNKPSALNSLRAGTVISQYDPYVVADAMKQYLRSLPQPLLTSHLLGEWARALEIKDRAVQLRRLQQIAHRMPPEYERNAGYLFRFLHRFTEYSARNRMTPAGLAIIFGPALLTAPAPASSSSTGADEPQTTTLADSNSGGHQNGNVYVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY01</accession>
    <name>A0A0R3WY01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008293">
        <property type="protein sequence ID" value="VDM27344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY01"/>
    <dbReference type="WBParaSite" id="TTAC_0000564101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000564101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000564101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000564101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14376" checksum="7E5C454A86635172" modified="2016-01-20" version="1">MSKGGDMLDLDTAPPLAIFSLPPKYVGQVTFKLHSSIPESKLQLSSFVSDVQVGLHACVMLRLHSFTFAFTFKHGVLGFVWLLFDCSGAAYKGSKQVAFHIDQQKCLPILAVRVASIHRHNSGFLPTVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYJ0</accession>
    <name>A0A0R3WYJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009178">
        <property type="protein sequence ID" value="VDM27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000583001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000583001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000583001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133124" evidence="1">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000583001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11718" checksum="1C201A18F97E167A" modified="2016-01-20" version="1">MTAHMSPMIVLGCLFLVLVVACPSASATSVLARVEEEESRHHAEGLSPAVWRPAVKAIFKKAAKKVVPAAKAFAKKAAKAVKEFAVYEAAKEAYDRGSKWIKRHWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZA6</accession>
    <name>A0A0R3WZA6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6097</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZA6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZA6"/>
    <dbReference type="WBParaSite" id="TTAC_0000611201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000611201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000611201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051918">
        <property type="entry name" value="STPP_CPPED1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE CPPED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="451"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000611201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79325" checksum="AEBD6CAF80DAD52B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZM7</accession>
    <name>A0A0R3WZM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TFIIIC_sub6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6249</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WZM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000626401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000626401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000626401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970620at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019322">
        <property type="entry name" value="TIMM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10171">
        <property type="entry name" value="Tim29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="253"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000626401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40830" checksum="DE5230CC6A9D743E" modified="2016-01-20" version="1">MRSHKLDGYGVYFQQIGSDYASTFRDTLKQVRDRPIRFAAIATTICAISTVYIACPHEFDYRAALLNASVDLWDTPASLQSQRSLIHIEERVTALFHGHLRYCSLLGLVHFVWRDDRTDGCRLYSEICPYANASSCSVSDSQIGSFRSFLRLFLYDAPPGKDVDEVGFADRARLNFTGALQLMPPLQLSDELKPGEIPERHEDASEQASHASTSSVPAQEETMESTGSHETIETANDPCKLEGGENEWEVVNETLVYADCVGAVESELMESGKSVLLVDLDAESPLIQIGPAIFQGTYADCLGTNLIFEKHHPDPENTQPSMKTIARPSIEIFASRAKNSVRPYFTYFGKTSKNLNLQRVFLKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZT9</accession>
    <name>A0A0R3WZT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000633201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000633201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000633201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286735at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000633201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10465" checksum="A50B2C6F8FDB6EF8" modified="2016-01-20" version="1">MSINDCPLLRIELLNPTQPTPSPGELETFPRITLSTEGIVHFEKRSRTPRRIGARSGARLSRFRTQPITIAEIAEIDGTANEESAKTSEGTTTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X000</accession>
    <name>A0A0R3X000_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS6398</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X000"/>
    <dbReference type="STRING" id="6205.A0A0R3X000"/>
    <dbReference type="WBParaSite" id="TTAC_0000641301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000013">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="17">
        <location>
            <begin position="142"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="15">
        <location>
            <begin position="369"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="16">
        <location>
            <begin position="722"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="125844" checksum="F3A060F299B1E5BF" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1P1</accession>
    <name>A0A0R3X1P1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS7130</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="UYWX01020348">
        <property type="protein sequence ID" value="VDM31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1P1"/>
    <dbReference type="STRING" id="6205.A0A0R3X1P1"/>
    <dbReference type="WBParaSite" id="TTAC_0000714501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000714501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000714501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000055">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
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        <property type="entry name" value="HATPASE"/>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1006"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000714501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112105" checksum="6198B5E7CC0B7217" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X219</accession>
    <name>A0A0R3X219_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7285</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020359">
        <property type="protein sequence ID" value="VDM31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0000730001"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:Prp19 complex"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
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        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000730001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29287" checksum="DA495B53AE7A7A00" modified="2016-01-20" version="1">MAAAADEKQGDRLNRLKQLQIKIDEAKKANHIQVVEEDRRKHLPSNWEAKQARMRWEEEEDAFRTECARKGVDVDRAKNLNISAELVNRLELRKRRKRPHLSVDDEAGDVAGFTSYADASHKKYLKQTKALKPDLVAYQKQKERLWTNRRFRQSHIDRGDLVYPTAHTIGLVEAIQTGTESSREAVERMVNTLKEQEKKKAVYSRRRAFDPDADIDYINERNKRYNELLDRHYGKYTAEIKQNLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2J0</accession>
    <name>A0A0R3X2J0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7492</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020377">
        <property type="protein sequence ID" value="VDM31882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2J0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2J0"/>
    <dbReference type="WBParaSite" id="TTAC_0000750701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000750701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000750701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007451at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Axin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014936">
        <property type="entry name" value="Axin_b-cat-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF2">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08833">
        <property type="entry name" value="Axin_b-cat_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="4">
        <location>
            <begin position="290"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000750701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="39277" checksum="88BE53E17D75992C" modified="2016-01-20" version="1">MNPPSHHFIPPLINQVGNDEEGEETTEIPNTGQEKEAPTKTTEAVKVEPKTETEVPSTMKTQQSQSLPAATESGDCTITKAMANLSVASTSSTTTTTTTTTTSTTTTTTASSKPSVLQRPWADRLLAAARVQHAQQGDNAQAILEDHCSRIWDTSADRTPTSSSGSGGDGLGVSALRPRLDAPGKSPAPIVGTAKQATKRREEEEVDDDCIHPPLLQESSSPPSATTTTTTNSSTRFDFHQQVNESQLVDVTSMRLQARCTSSPAASSTATGGGGGGGGGGGSVGSGGGSGGLVVGYYLCDDPVPYRSQWPSNVITLGQFKHLVPKKGLFRFFFKTTSDEFDSGVVHQEISNDDAVLPLWEGKVVAKVERVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Q4</accession>
    <name>A0A0R3X2Q4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADK_lid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7573</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020384">
        <property type="protein sequence ID" value="VDM31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Q4"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Q4"/>
    <dbReference type="WBParaSite" id="TTAC_0000758801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000758801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000758801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011105">
        <property type="entry name" value="PRK14532.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000758801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29423" checksum="98005563495A1358" modified="2016-01-20" version="1">MGIFSFLGLTRNDEVENASKTNLILIGPPGCGKGTQASRLMKKYEVCHLSTGDMLRATTSSGSELGDKIKKIMEAGQLVSDDIVCELIDKKLDSPECRKGFILDGFPRTIPQAEKLDELLHRRKEDLTAVVELRVADELLITRICGRLFHLASGRSYHETFNPPKVPMIDDITGERLVRRSDDTKEALQKRLESYHNMTSQLLEFYKKKNLLLTFDGSQSMDKVFTDIINEESYPDLYSDCLKEALINLISRVFVRITDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X321</accession>
    <name>A0A0R3X321_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7704</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X321"/>
    <dbReference type="STRING" id="6205.A0A0R3X321"/>
    <dbReference type="WBParaSite" id="TTAC_0000771901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000771901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000771901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20917">
        <property type="entry name" value="DCAF15-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032734">
        <property type="entry name" value="DCAF15_WD40"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000771901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="624" mass="70069" checksum="BB6AE28935697120" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X329</accession>
    <name>A0A0R3X329_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7714</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020397">
        <property type="protein sequence ID" value="VDM32148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X329"/>
    <dbReference type="STRING" id="6205.A0A0R3X329"/>
    <dbReference type="WBParaSite" id="TTAC_0000772901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000772901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000772901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5848685at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF24">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="738"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="80"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="290"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="412"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000772901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="814" mass="91294" checksum="8BE6D42972B56BA4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3C8</accession>
    <name>A0A0R3X3C8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YLP motif-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7831</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020409">
        <property type="protein sequence ID" value="VDM32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3C8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3C8"/>
    <dbReference type="WBParaSite" id="TTAC_0000784601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000784601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000784601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="513595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000784601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69647" checksum="637CBA91AD1F22B6" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Q9</accession>
    <name>A0A0R3X3Q9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS7981</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020428">
        <property type="protein sequence ID" value="VDM32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Q9"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Q9"/>
    <dbReference type="WBParaSite" id="TTAC_0000799601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000799601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000799601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ssl1-like" evidence="13">
        <location>
            <begin position="75"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000799601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45044" checksum="AD5A9671231D3FBC" modified="2016-01-20" version="1">MSQPSDKRDYSWVAGYEKTWESIKEDQSGSLVASLEKMVRDTHADLRAKRQHTNATAVTIGGTPRLGMVRHLYVVIDLSTAMLERDLHPNRLICTLRCLKKFVENFFDQNPLSQLGIISTSSSKAQLVSALSGGFIQHLRALEELGKHQQHMPSYSSREVLLILASMTTCDPGDIHQTIQSLITHRIRCSVISLAVEVFVHRALAEATEGSLTVIMDAPHLKAVLQSLVHPPPVSEDKDAALLRIGFPHSTAADFEQFPVRVCMCHLPNVENKGEVTGGANSECNVTVGSSNRPRGSYLCPRCHSAYCELPVECAVCGITLMSAPHLARAYHHLFPLPRFLEVPRSEAPSTASKGDPLGCGGCNVNLQLKSVEVRFYVDIEGGFECGITALNRHRAGERPMIVTSPWNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3X1</accession>
    <name>A0A0R3X3X1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCV_T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8057</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020439">
        <property type="protein sequence ID" value="VDM32548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3X1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3X1"/>
    <dbReference type="WBParaSite" id="TTAC_0000807201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000807201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000807201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000807201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35628" checksum="19A6D82C55A28C4A" modified="2016-01-20" version="1">MTNDARQIATKNSLIYSLFLNAKGRVLSDTIIYHVNHQDHEDPHFIIECDSKCKSTLLRLLHFYNIRKKIQISEEPTLRVLVNLNAGEAEQSIDGALFTGKDPRAVPDWCSRMLYCPAAAPETAYVDGDTLYRRSRYCLGVPEGVDEFKLGESLPLEANADLCHGVSFSKGCYVGQELTARSRFVGVTRRRIAPILFESSSKPSIIPLNSPIFRVSKADNKVVGSRPVGWVRGQEDPSPVLVPPFQHYGLALLRLAECAAAVTSGDRLVVAVSETAQVSEAAPIDLSMTYIVRPFAPSWWPEDIAIGLPRIQPFLVASSTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X499</accession>
    <name>A0A0R3X499_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Selenoprotein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020465">
        <property type="protein sequence ID" value="VDM32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X499"/>
    <dbReference type="WBParaSite" id="TTAC_0000822501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000822501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000822501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272511at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000822501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17240" checksum="D4FEB653E634C7DD" modified="2016-01-20" version="1">MDPDFEIEDVNEYGVPQTTASNGYGVVFKILVGLIFIALYFLVSRFSAAFGTRLARLATDTHQRNYDVEMREARRRLQERFDNERRNRKTQNNGNIPTEDTEKSKSKADPQKSTKRIKAPNPETLNSSGYFPLIGDSSGSNVCFRRSRKPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4D8</accession>
    <name>A0A0R3X4D8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8254</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020473">
        <property type="protein sequence ID" value="VDM32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4D8"/>
    <dbReference type="STRING" id="6205.A0A0R3X4D8"/>
    <dbReference type="WBParaSite" id="TTAC_0000826901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000826901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000826901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000826901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28404" checksum="B0FD0A025A292DBF" modified="2016-01-20" version="1">MPFASFKNIQKRNARLHKERSQPAARAKYGTLPKKKDFILRSRDEEAKRNRIRELKRKALTKNEDEFYFAMHNAAFSEEKGHIPLNNTKEYSDSELADMLSRDIRYLRREFTIEMSKIQDLESRFNLLTADPSVTSKRLKPKRTVFVESVEEARAVRASFDPSVVPTQISSSISASDADALMDLQAAGYKELLERLTRAEKLKLAIARREAKDILMRNADSKFKVVRKGNANRAPVYKFEPKRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X536</accession>
    <name>A0A0R3X536_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8545</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020528">
        <property type="protein sequence ID" value="VDM33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X536"/>
    <dbReference type="STRING" id="6205.A0A0R3X536"/>
    <dbReference type="WBParaSite" id="TTAC_0000856001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000856001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000856001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="49"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000856001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="742" mass="83685" checksum="54EA7ECA65596716" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X552</accession>
    <name>A0A0R3X552_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Early growth response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8561</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020533">
        <property type="protein sequence ID" value="VDM33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X552"/>
    <dbReference type="STRING" id="6205.A0A0R3X552"/>
    <dbReference type="WBParaSite" id="TTAC_0000857601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000857601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000857601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000515">
        <property type="entry name" value="early growth response protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000857601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="613" mass="64388" checksum="CCC8D4FAAD9E9471" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5F3</accession>
    <name>A0A0R3X5F3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal-dependent decarboxylase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8678</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYWX01020561">
        <property type="protein sequence ID" value="VDM33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5F3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5F3"/>
    <dbReference type="WBParaSite" id="TTAC_0000869301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000869301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000869301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250729at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055102">
        <property type="entry name" value="PDXDC1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF1">
        <property type="entry name" value="PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22937">
        <property type="entry name" value="PDXDC1-like_cen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDXDC1-like third" evidence="6">
        <location>
            <begin position="586"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000869301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="874" mass="97396" checksum="5DD754AEE2FE156D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5P6</accession>
    <name>A0A0R3X5P6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein YIPF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8788</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020588">
        <property type="protein sequence ID" value="VDM33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5P6"/>
    <dbReference type="STRING" id="6205.A0A0R3X5P6"/>
    <dbReference type="WBParaSite" id="TTAC_0000880301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000880301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000880301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000880301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27415" checksum="B891C1C29B0BE222" modified="2016-01-20" version="1">MSGIYVPVPLEPQPEVSSLSDTVEGSSQVVQRMFGGLIPFSKRFSLSVSLRPAPDLYGPFWIIVTLVFSIAFSGSIYEYMISKNASALSTFNFGRATISAAILFVYWCLVPIILTSLTWFRGRNAYSDAQGTGKVPEFSFGSLFSVLLAIYGYSMVSFIPVAAAIGLLVLIVIAHIAMTASLFVVFFHQPPLEPKPDLGVQASDANALNNPTLQETIRAGVAGDQKDASPKEAPIKPAKDIAEKKAEKDNPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U9</accession>
    <name>A0A0R3X5U9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase_M24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8848</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020606">
        <property type="protein sequence ID" value="VDM33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U9"/>
    <dbReference type="STRING" id="6205.A0A0R3X5U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000886301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000886301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000886301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000886301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43344" checksum="A44F856B2700A667" modified="2016-01-20" version="1">MSDYESDEEPTAADETVLNKYKVAGEIAHTVLKELMKQCVPGAKIIELCEYGDRRIVEETNKLFKKEKEMKKGIAFPTTINVNNFICNYSPIAGEENAIEELNDEDLVKINLGAHIDGFSSVIGHTFVVGAGPEKKVTGRRADVIVAANIAAEVARRLVKPGNENYEVSDMITKAVADFDCRPIQGVQSNLMKKLVFDGDKSIVLNPDDDHKKGVEKCTFEMYEAWLLDIVISTGSGKTREHTARTTLFKKNETVYHLKMKASRKFYSEVSTKFQEYPFNIRSVEDIKSARYAVTECANHNVITPMPVLVEKEKEFVAQFRFTVILMPNGLMKITGLPFDSSLYKTDFKTVDPEVKDLLSQPVKSSGGKRKKPVNASNDQGRPAAQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6I2</accession>
    <name>A0A0R3X6I2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyprenal reductase</fullName>
            <ecNumber evidence="2 9">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9102</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8 9">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="2 9"/>
    <dbReference type="EMBL" id="UYWX01020681">
        <property type="protein sequence ID" value="VDM33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6I2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6I2"/>
    <dbReference type="WBParaSite" id="TTAC_0000911701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000911701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000911701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000911701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36684" checksum="31E6E276E05F0BEE" modified="2016-01-20" version="1">MLFDDGANILECFVIYAYVLSSFVSFATIWLYRFPQMGNSVFLFRTIFLFGKCAPNYGRIYTVLQVPKRFFVHFYVTAVIVSLSTILFVLHCHSKRLEEKFNAIAVMLWQFCCTGSSIGANIGLFVMFCHALKRLYENLYVHLFSDSKMSIAHYFIGHFFYLTMSPCIYWSSQYAGYSTTAILLDFILDKRGMVAIIAYIFLAFLTMALQHLVMRQLASTRLRASKGYSFLERRNAYLMPEGYMFTYVTCPHFSLEITLYMLTHAFLGLRWMPFTAVLLFVLSNQLCSAVINHLWYLENYPKFAQSRKMLIPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6J6</accession>
    <name>A0A0R3X6J6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS9117</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020684">
        <property type="protein sequence ID" value="VDM33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6J6"/>
    <dbReference type="STRING" id="6205.A0A0R3X6J6"/>
    <dbReference type="WBParaSite" id="TTAC_0000913201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000913201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000913201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="155"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000913201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46947" checksum="10F0D2061F9C409F" modified="2016-01-20" version="1">MVVGNLHKNLEGCRVPVRLKQSKLYRNTDEFFNKRLDEWVEQSRIDFDKLEYPSKKLPRDGSSASLSVLSTADPTVKFSVTTEDPTENEHLQILSPKTRINPTGALQLKRKRHSDDETPAQTMESRDEPDRPKSQVVPRQTGSMISSHHEQDVVTRIRNIEWIQIGRHKIKPWYFSPYPYELISAPCIYICEFCLKYLKSEGCLKRHLTKCQFRHPPGNEIYRKLPHSFIEIDGRKNKIYAQHLCLLAKLFLDHKTLYYDTDPFLFYVLCEIDAYGYHLVGYFSKEKESSEDYNVACILTLPPYQRKGYGKFLIEFSYALSKIEGKLGSPEKPLSDLGLLSYRSYWTMTIMEILLSIKPSEPGQESENIDAYRRSMEKRSVRVDQSCLHWKPKDWSKRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Q3</accession>
    <name>A0A0R3X6Q3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vesicle transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9182</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020706">
        <property type="protein sequence ID" value="VDM33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Q3"/>
    <dbReference type="WBParaSite" id="TTAC_0000919701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000919701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000919701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000919701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8694" checksum="275C0A7AE8C02E81" modified="2016-01-20" version="1">MLYSSSTFHWVFFKPFATGGVLSYLQWILIASIIRIPEVVVKGVIAVGHGLILKFALNMGCQRFRQYCAPVVFKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6R5</accession>
    <name>A0A0R3X6R5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Grh/CP2 DB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9195</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020711">
        <property type="protein sequence ID" value="VDM33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6R5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6R5"/>
    <dbReference type="WBParaSite" id="TTAC_0000921001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000921001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000921001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF21">
        <property type="entry name" value="GEMINI, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="9">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000921001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="830" mass="90565" checksum="5A80BD88A259E840" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7J5</accession>
    <name>A0A0R3X7J5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9505</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01020853">
        <property type="protein sequence ID" value="VDM34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7J5"/>
    <dbReference type="STRING" id="6205.A0A0R3X7J5"/>
    <dbReference type="WBParaSite" id="TTAC_0000952001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000952001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000952001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000952001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58920" checksum="1FDB2F08093DCADE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7M5</accession>
    <name>A0A0R3X7M5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9535</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020874">
        <property type="protein sequence ID" value="VDM34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7M5"/>
    <dbReference type="STRING" id="6205.A0A0R3X7M5"/>
    <dbReference type="WBParaSite" id="TTAC_0000955001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000955001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000955001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000955001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="905" mass="96133" checksum="30B6D4D43771C1B3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7X3</accession>
    <name>A0A0R3X7X3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9633</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020947">
        <property type="protein sequence ID" value="VDM34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7X3"/>
    <dbReference type="WBParaSite" id="TTAC_0000964801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000964801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000964801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257319at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000964801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49106" checksum="7F53C72F2B22C224" modified="2016-01-20" version="1">MSIWSNLEPQFQASDLPNEDRKQFTQSRGDADTQFKLHWNGKHKPQGGMLNNGTQLRGKFSPLHSNNPTRDLVVGRREEIKTRTKFSRPLKPTAIRRMRSDLLNLTPNKTTTKRNVRFQKSVYDMLLIDEVGEDDYETQKERELKRLEEIQEQRRIRMKHDSEKYGTHRVGEYSYLLPIEWMLDRGGVPYPLGYYPINLYDLITDNHPSLNLSLLPQRDGLPRRKDQVQLRYLPANLRAALIPLAFTSMDVLGLILLMVGWFLLLLCTAALIGYQVEANAATKCFFRISKNLIYQWEARRDPGLPDRLKKQAEDAGITQVVLADCEFLSIIKEGGRPSPSCMHLNLVYLLQPNTWPYLVLCKKDIGDDRFNRIALCIQHYYSFSDLIKRWEALKNSKNMEIVNAAIALMDAFLDGEYNYTCACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Y0</accession>
    <name>A0A0R3X7Y0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">39S ribosomal protein L30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9640</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020951">
        <property type="protein sequence ID" value="VDM34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Y0"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Y0"/>
    <dbReference type="WBParaSite" id="TTAC_0000965501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000965501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000965501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9973389at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000965501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34944" checksum="A104E3AB8509BC7E" modified="2016-01-20" version="1">MFALDVHGFAVFVARRSQLLTTVRHFTTSYQLSGKARTYESKPVPGSLDHLDPLAWAQRLFDLHEARKAYTYSNEPSPLFMICRIKPIKGTTFFERAFLEKYGIGPKTKVSVAMPCIAPQQHQWKVVKNAPQTVKEMDHIKHLVRIQPVSFLDGLPLSEDDLVNFRLLPNGVFVRRGNSPFRSGKSLDLAEFEIIKHPCVSEDKIPEVNENSLYLTRSYLKSWHNQRWQHHKLLSEFFTAKYKYRLNQDGQEYRYSGLWRLDDAMRQSLSQRKSLDGTYKARNNSRFEADWGTYPWSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8U2</accession>
    <name>A0A0R3X8U2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9952</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021188">
        <property type="protein sequence ID" value="VDM34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8U2"/>
    <dbReference type="WBParaSite" id="TTAC_0000996701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000996701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000996701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6228213at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000996701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39301" checksum="390D140695C82D79" modified="2016-01-20" version="1">MSRSANVGRCISVTTSTTFETKFEIRSVRVDLPQLSGGIVQHGPPIEGEVKTFKEIGIAVHHIDGAMGGWCTEEEEEEDVSLAIVTKRVHLPVLGTILVLVVVVESEGTQNTTSSNLRLFHVLLDYGMRLLHAGKDFFEVKDLIRVSRVELQNIRIHNLKSIYEASVPELRALPVDESMKEGWKVTTRCFSIDLNIGLRELTVSAESKLKVFFKTKFHPFEMIIKPLVLHVRLRVCFPFLSVSQSLALDKGSASNLPHFATFSIDLEDVEIKHWKGVRIKGKGTFNKVAGFLINSGVFTGLIRKKIVNKLRKYMPIKFAALKNKIYSKLNKLVNRTIERYGVKSTRKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X936</accession>
    <name>A0A0R3X936_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS10046</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021266">
        <property type="protein sequence ID" value="VDM35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X936"/>
    <dbReference type="STRING" id="6205.A0A0R3X936"/>
    <dbReference type="WBParaSite" id="TTAC_0001006101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6144223at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133248" evidence="11">
        <location>
            <begin position="24"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="181"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="64146" checksum="5272E02ACFE293CF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X940</accession>
    <name>A0A0R3X940_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS10050</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01021272">
        <property type="protein sequence ID" value="VDM35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X940"/>
    <dbReference type="STRING" id="6205.A0A0R3X940"/>
    <dbReference type="WBParaSite" id="TTAC_0001006501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="457"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="901" mass="100869" checksum="9018973A4A5EFE0F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X943</accession>
    <name>A0A0R3X943_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021275">
        <property type="protein sequence ID" value="VDM35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001006801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16509" checksum="31D5D893E0A215F4" modified="2016-01-20" version="1">MWTPFLLLPPSMRQFECVEMCRVGLTDADPCEGVDDYQQGGEARARNAEVEGCEGGRSAGAQTLGXXXXXDTWDVHVTSEGKASALNRINSSTDGKDCQFACAPVPHTGMSSSLSRPLHGKMVHQSAAQLQRLYYLALLDDIIESGTCACAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X995</accession>
    <name>A0A0R3X995_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021313">
        <property type="protein sequence ID" value="VDM35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X995"/>
    <dbReference type="WBParaSite" id="TTAC_0001012001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001012001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001012001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001012001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18607" checksum="19EA99F78196BD6C" modified="2016-01-20" version="1">MSALTPLYAVDAFGEENEAFEQEVIKAIKTHPYGKYLARRKRFIYFTKQVMLSATFLEFDCNCEASNLRSIGCRGRITRHSMQIDWTHFYPRGRSPLDEGVACSPAFMPHQFPSPVGHIENKIDEVVVVSVVKRAVHFEPKSLLRNQASLLDVAEVERDFDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9K6</accession>
    <name>A0A0R3X9K6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10216</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021433">
        <property type="protein sequence ID" value="VDM35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9K6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9K6"/>
    <dbReference type="WBParaSite" id="TTAC_0001023101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001023101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001023101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001023101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25092" checksum="7A931A4D0F47646B" modified="2016-01-20" version="1">MNFKESAESLKPLTDEEKRAQMRRLEEAMLQRKKKREEEDRQKCLSEEKNRRLQGKATQSAKALFREELMRREAEQLKKDRAEDKAYRDKLLADVAAERAERAAKQKGIVSKTAFTTVPSLSGATSLDPAECRLQIRTPIGEPLRGTFKSSESLGAVVLYVSQNWPMDPDGTMRMSIDSQEITLQTTFPNRKFGKDDVSKSLDELGLCPTAVLMARRNVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9K8</accession>
    <name>A0A0R3X9K8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BEACH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10218</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021435">
        <property type="protein sequence ID" value="VDM35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9K8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9K8"/>
    <dbReference type="WBParaSite" id="TTAC_0001023301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001023301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001023301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="392"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="519"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001023301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="738" mass="82254" checksum="75B8C0BA41ACF61A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Q8</accession>
    <name>A0A0R3X9Q8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SMC hinge domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10268</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021491">
        <property type="protein sequence ID" value="VDM35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Q8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Q8"/>
    <dbReference type="WBParaSite" id="TTAC_0001028301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001028301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001028301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="531"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="412"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="787"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001028301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="880" mass="98139" checksum="CA11F5DAB404AC6C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA23</accession>
    <name>A0A0R3XA23_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10383</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021625">
        <property type="protein sequence ID" value="VDM35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001040001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001040001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001040001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1278353at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051866">
        <property type="entry name" value="Intracell_Sig-Traffick_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508:SF8">
        <property type="entry name" value="LD24550P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001040001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="67129" checksum="DDBF431255C39F17" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAL2</accession>
    <name>A0A0R3XAL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10573</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021880">
        <property type="protein sequence ID" value="VDM35553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAL2"/>
    <dbReference type="WBParaSite" id="TTAC_0001058901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001058901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001058901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001058901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10005" checksum="1E1EAB2C78097E54" modified="2016-01-20" version="1">MSVRREIGDESYFSIIYSVVSSQFEGAASERQLLEEQQRQQHLLHIPPTCDGATNDDDDEEEEKQGMEVLTFPLGGGGVRDNAEEVGSGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAM1</accession>
    <name>A0A0R3XAM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10581</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021897">
        <property type="protein sequence ID" value="VDM35561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAM1"/>
    <dbReference type="WBParaSite" id="TTAC_0001059801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001059801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001059801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001059801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="58" mass="6019" checksum="154E7B12F57EE759" modified="2016-01-20" version="1">MQKHSPTASAAAAAAAAADSGYACLPQHYLPCSWVCVCRRSFAPEILVAVLLSGQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAS6</accession>
    <name>A0A0R3XAS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10636</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021967">
        <property type="protein sequence ID" value="VDM35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAS6"/>
    <dbReference type="STRING" id="6205.A0A0R3XAS6"/>
    <dbReference type="WBParaSite" id="TTAC_0001065301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001065301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001065301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273447at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF8">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001065301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41479" checksum="F3C22B708F7B3C7F" modified="2016-01-20" version="1">MLDSPTNARRSCSLTNDSVPPKRYKTPQRRPKLVEALTAPLGSGTNLPDAALRLFEHREMLRKYKLILNALVVKHTYLRTKSADNVIALISTDLVEVERLLRKAATKLLWSDAGRLMATWTHAPLFERRDGKADGLLERNGNAERRNAEIKEAGKKVFALLENNRQLFRASADSSAWNAYVKDVDSIITSSFVETIRCSLDFLLSETNSENPDLHPLFEIQMDLTISGISFVPALEQGPNSTFFDVCNAILEDIYKQADQMTRVTLEDGEGQTYEEGIKKNIELEELRQIFIERVEAAVQGAREYNDSMERFAYLWTDNREASLKDFLNEENNNSDDLHTTPSLKKFKRKIEEYEAIYSEARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB76</accession>
    <name>A0A0R3XB76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synapsin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10786</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022242">
        <property type="protein sequence ID" value="VDM35766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB76"/>
    <dbReference type="STRING" id="6205.A0A0R3XB76"/>
    <dbReference type="WBParaSite" id="TTAC_0001080301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001080301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001080301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF17">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001080301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="497" mass="53529" checksum="7EAC323D1C153203" modified="2016-01-20" version="1">MFGGLDMCSIKVLQDTAGEYFIQDWCTGQTPTKILDSGKKTVDCTQVVVRKVYGSDFILLGDGQEEDRMRIAELLLQRMEYAAKSATGPMSQPKVSQTSTKLIQASTPSAIGQVAPSMQSVVGTTTPTREQSMQPTFGQIRQQQQPPLSSVSNQEQQRLPKTQPPPPQPPPLSGPSSSQGYREPLSGRSNISGGAMDFGQSRGSLQSQTKTQSQFEPSIHQSQSSRNEFSTQEAFDKPKTSMRTTSMDFSSRPPSKRTSYSREGDESMRMSSSSTHAAVSIPPSESRPSESWSSGNSGRPIREPSVESLESMRGRGQKEAAPQPPRQSSLINSFETRTFDSCGSGTASSNSATSTTIFDPSMNIFQPQVQSKSSISTFQSQSQERDTPTSMKFDTSPLDFGRSALGSQHNDPWSVPPPPPPSSSSVSVNQTSQLPSLLTTSSASSSSSSSGTTTTTTTTSMATRSRQTSQQSIGNADDADDTMKNLRKTFAGIFGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBL1</accession>
    <name>A0A0R3XBL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10921</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022530">
        <property type="protein sequence ID" value="VDM35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBL1"/>
    <dbReference type="WBParaSite" id="TTAC_0001093801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001093801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001093801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246490at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001093801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33750" checksum="E31B8058C323A83A" modified="2016-01-20" version="1">MDKRRHQQQELKSVELRRPDASHPWGICYAVLPAGPEILKVMSESPAYGHLRSGQVIKTINGQSVLGLKREDITDLLNIDDEVVALEVTPAVTSDPKSLLFGREYGRGSVGPSSFNRQYRRNSEMSTTLERRGSNACVEMPTNLPNCRDEFERIHSQRKQSRELTLNQMENLRLQRAASVDICNSDRRSGSAFIPQPLQQSGESVDAQKEEGNGMTGLRYMGGHIPSRSFKALALLMGMDPSDTNMGQQSTKPASTEPCRTVIDVRAAAEAMRKESLSHAPSNGHSSVSSSLPPHPPSTCNPSLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBM9</accession>
    <name>A0A0R3XBM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage major capsid protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10939</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022576">
        <property type="protein sequence ID" value="VDM35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBM9"/>
    <dbReference type="WBParaSite" id="TTAC_0001095601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001095601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001095601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001095601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14841" checksum="5544F3352596C3FB" modified="2016-01-20" version="1">MTTTYAVQSFDNLDAIQADVLSPYRFEKVAGGQPAGILMQAPSSSLLTMDPRAAQPGTSEEFGDASESSLAQKEKIFFVENASRKMSSTTYSLAGKTPVICSSVGTLTNAVSRKWNFTSVMLTGMAKRLPPLSYVATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBQ2</accession>
    <name>A0A0R3XBQ2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10962</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01022612">
        <property type="protein sequence ID" value="VDM35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBQ2"/>
    <dbReference type="STRING" id="6205.A0A0R3XBQ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001097901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001097901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001097901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001097901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38591" checksum="FA3AB3278D09DE05" modified="2016-01-20" version="1">MASEDKENVADEPLLVPNPRRFVVMPIQYHDIWEFYKKAVASFWTVEEVDLAKDLTDWENLNDGERHFISYVLAFFAASDGIVNENLTLNFCNEVQVPEARCFYGMQVAVENIHSEMYSLLIDTYVKDPAERDFLFNAIQTLPCVAKKADWALKWIANKRASYAERVVAFAAIEGVFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLIFKHIVNKPTAERVYDIMTEAVSIECEFLTDALPVDLIGMNCRLMCQYIRFVADRLLTELGYDKIYKDKNPFDFMENISLEGKTNFFEKRVAEYQRAGVMSRMRGEDTHKFTTDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD28</accession>
    <name>A0A0R3XD28_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DRMBL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11438</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024200">
        <property type="protein sequence ID" value="VDM36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD28"/>
    <dbReference type="STRING" id="6205.A0A0R3XD28"/>
    <dbReference type="WBParaSite" id="TTAC_0001145501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001145501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001145501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001145501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30004" checksum="E256A589EFC0C059" modified="2016-01-20" version="1">SDAWHNLLEILIECDYDVRQFLLTPLQFGVPNGRLRYYLVARLRTRVEQPMFNFGHSVEHPLSRSTLITMPSHELPPIPNCECVVCTKKVSDIVSPENHFTEYIPLCSPISNYLLPDCDVPESLFLGRSELTKYHRILDIVTPNSKRSACFTKGYAHRFEGTGSFLQVPQPSNVLKSCPADTTCLPRIRAFHSKEIARLLCFPEYFGMSISLLSVLHWLPVMCEFDVTEFPESVNEKQRRRLLGNSINVLVVAHILYWAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD44</accession>
    <name>A0A0R3XD44_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024260">
        <property type="protein sequence ID" value="VDM36568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD44"/>
    <dbReference type="WBParaSite" id="TTAC_0001147101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001147101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001147101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001147101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17257" checksum="828F120076344959" modified="2016-01-20" version="1">MYVAGPTLERASLLHVCKITHERPTPSQSEAPIQSRFEFASTTAAATGDDNRYWYLRDPRWLGARPRLLGWNPLADLFALFPNLNRLEIALTQLTGPMLLRLIYQTQLSVLILTQLPQYRKFQSEWVADVPCFQLWTCQRELGEIHGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDS6</accession>
    <name>A0A158RDS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Inhibitor of growth protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1440</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000315">
        <property type="protein sequence ID" value="VDM17999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDS6"/>
    <dbReference type="STRING" id="6205.A0A158RDS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000145301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000145301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000145301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM17999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000145301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51956" checksum="E113C8E84F97A6A0" modified="2016-06-08" version="1">MLYFDDFMEDTVNPLNLRISAFFDNCKSSRLSEREKDVEYDQILKYQKVMKKLDSELEKFRLELEADNSGVTSKIEHRVRTILGRNMPGVSRLEKRRAKFRSGHFFNNNRAISKRRMPFSMELPEKQFYVLKRRFAAFDTPMNLPPPSSYGGNGGPFMVEETSNPLMSESNNRLSSSDVMRRVPSAGSLNSMDQNIPDHDFGTFQGDSQDYCDDDEDNLQLSFDSTKRSRALDTLQRAAGISMDHHRVHHGGSSCYSPFVNTSDTEAVTLAAGGNAVVTDSSIDELLANPTVSASPSLKCGESPRWIGGVTASVDKTRRVGVHTRRPSQMSSSTIDTNDETGGYVSSSELHHLSHSHRYALAQSSAVPLKDQQQQQQRQQQDSHVSATAGGAVDESKYCFCKDVSYGDMIACDAPNCPIEWFHYPCVNLTVAPKGRWYCPICTANGAAGSRFAGIASTSRKRMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDX7</accession>
    <name>A0A158RDX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6248</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDX7"/>
    <dbReference type="STRING" id="6205.A0A158RDX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000626301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000626301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000626301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="435"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000626301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="869" mass="94355" checksum="F91F6423B4327750" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDX9</accession>
    <name>A0A158RDX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IMD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6284</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDX9"/>
    <dbReference type="STRING" id="6205.A0A158RDX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000629901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000629901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000629901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000629901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="967" mass="104519" checksum="1040D06A3729EDDE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REV2</accession>
    <name>A0A158REV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8127</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020451">
        <property type="protein sequence ID" value="VDM32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REV2"/>
    <dbReference type="STRING" id="6205.A0A158REV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000814201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000814201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000814201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="197"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="330"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="594"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000814201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="733" mass="78239" checksum="56177BE5E3F204D9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EKJ5</accession>
    <name>A0A3P7EKJ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynamin stalk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001783">
        <property type="protein sequence ID" value="VDM21703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EKJ5"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="256" mass="28984" checksum="765FE025D9CAAD0C" modified="2019-02-13" version="1">MLLQIITRFNTAYCNTIDGVSKDIETSELCGGARICYIFHEIFYSTLGRIDPLGGLNTLDILTAIRNSTGPRPALFVPEVAFELLVKRQIRRLEEPSLRCVELVHEEMQRIIQHCGTQQEMYRFPNLHERIVDVVTSLLRRRLQPTNEMVTNLVAIELAYINTRHPDFTEELMLHRQQAPPGLNNLTLNEASSQVQAGKRTKQLATERRSSAAPVQRSSDALQEADSSDSANPSGFHATPDIVCLFKLSNQHRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQ80</accession>
    <name>A0A3P7EQ80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004967">
        <property type="protein sequence ID" value="VDM25370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="90"/>
            <end position="178"/>
        </location>
    </feature>
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            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="389" mass="42920" checksum="0748755EF1C6603C" modified="2019-02-13" version="1">MLPILGILPRSPSELSGGRDSYTWNVSLRPPQKYITNGGLPASFTILFSESLTAAKSRQGRCYNIPLRLWMPPKMYLTVHLPKPGLVIRRSPSPPLHSSASSSRTSALQHKHSTLVTVSSSPISPPTNTQKSPMYTPYAMRFFRSSSRRATSRSESSHHSTERESISTKNPQESSLRVERALDSGVNHSAVSDITHGLGAVVVAEELLPQGRAQTLRDEQKELNETNDDHVAVVPHNNLDVKKQHQVTTSKHEFAGEKNKGSNESNTLLRLIQDGAFKWAKKSTVVRTLPMGVEMPTEIHIVTSNNNSSVSTHATPRRRKLKKNHNDSCSVRIPPLVPEYVLTPIAPDIMPPLPPLVLAATLLTEIQNEEPEENTANNVNEFLDPSDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F9G8</accession>
    <name>A0A3P7F9G8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004880">
        <property type="protein sequence ID" value="VDM25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F9G8"/>
    <dbReference type="OrthoDB" id="6273470at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="113" mass="13317" checksum="E666ECDBADC38CC7" modified="2019-02-13" version="1">MNAAMENQVAAKDRELKSCNRRSEELSTKLDIIRRWCEWLIQPPGSQFARPDRSPYFETDEFTLYGESADLGEREERMCCRSYRFLSGTEGNLKAHIHCQRYMNSLWRSCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCP0</accession>
    <name>A0A3P7FCP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006645">
        <property type="protein sequence ID" value="VDM26499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCP0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="44" mass="5310" checksum="5ADA24DD3E964431" modified="2019-02-13" version="1">MTLAQLVLLAHRRNKQERWDWLAAFVYYHWTGCDHLMVCVFVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FD25</accession>
    <name>A0A3P7FD25_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006925">
        <property type="protein sequence ID" value="VDM26639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FD25"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16051" checksum="E9A9354D8D65CD0A" modified="2019-02-13" version="1">MKIKPLYPYWKALRSGLACYVCVSINGSNPSCEDPMDGAVPVEAPCRQGRSGYAGLSYARYCVKIKGRRVSDGQKICIRRCSMQKLGGIHTHCGQFHLSDELYHGCIATCAQNWCNIGRSTTYPLIVAIVVLFVFLFHANQSLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FDC1</accession>
    <name>A0A3P7FDC1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007259">
        <property type="protein sequence ID" value="VDM26844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FDC1"/>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="106" mass="11996" checksum="459BEA023C0DD0D3" modified="2019-02-13" version="1">MRFMHNAFFTLSAEAFCKAVNLIDRFIVKVKVKPKYMACVAAAAYYVAAKLVESTPQLNMCTLLKRRARYDLPLSPSLGPLGMTIWYTRFPSRSQGSSTLNYYNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFG6</accession>
    <name>A0A3P7FFG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008685">
        <property type="protein sequence ID" value="VDM27509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFG6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="52" mass="5693" checksum="F3E8E4C110B3E2D5" modified="2019-02-13" version="1">MMKGAEAHPHVDAMQTVRHLMAWIRHSKEEASEEPPPPPPPPPPPPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FH25</accession>
    <name>A0A3P7FH25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009980">
        <property type="protein sequence ID" value="VDM28069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FH25"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="76" mass="7986" checksum="561C331397D02BBB" modified="2019-02-13" version="1">MSLQFSIWLIVLLSLTSLFAIWFILCGLFRRADAYRTPNAGLSGGGCAFGDLDGAAFGEGGRSGSLFGGMNFDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FH85</accession>
    <name>A0A3P7FH85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009139">
        <property type="protein sequence ID" value="VDM27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FH85"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="92" mass="10447" checksum="4B713C59CF9CF6CF" modified="2019-02-13" version="1" fragment="single">MDLIVAFSNPCLGPPWCPDWHDLEPLLLRLWGEEAVAESTPGWTSSPSLSCLQRMMRISTMAVEERRLSPIVTGLLTAWHLIHPGMMMRMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FTY5</accession>
    <name>A0A3P7FTY5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020404">
        <property type="protein sequence ID" value="VDM32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FTY5"/>
    <dbReference type="OrthoDB" id="27234at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="2">
        <location>
            <begin position="333"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="3">
        <location>
            <begin position="513"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="77748" checksum="95BCFC7836122549" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FUW8</accession>
    <name>A0A3P7FUW8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023876">
        <property type="protein sequence ID" value="VDM36366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10593959at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="152" mass="17640" checksum="DA74B7EC7A87E80D" modified="2019-02-13" version="1">MTCKIVNEVGYDERPIRVTFIPELEFEIRPPNKQDVTLAQNISINCTARPSELAPMIVWKYSDESTGDFKELDSLAERTEGXXXXXPRYATYFTIRVSLLKQSGRGIERQLQFDSLKDVHMAEYMCNASNFYNRDKEGRRVDVRQIVRLTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FWA4</accession>
    <name>A0A3P7FWA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020423">
        <property type="protein sequence ID" value="VDM32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FWA4"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="412" mass="44606" checksum="F36AFB87A7C2A89B" modified="2019-02-13" version="1">MNFSNPSIPCAMTNGVSYIPVNNQAAQISNNNLLSPTVILPQQSAGTADYGNQISSMPHQSGASIIQVPLSSSTLQRDQCPSYLHSANFIPAGAILFTNTPVIIPSTGLANGNAVEVLYAPQTPPTSLSHPQITPHIHVQGSPPQQHHHNSPCFHEVKSQEYAALVKDLVKQRLQTSKQQQEEMRRSETHSSLFQQDPSATQRPTISNISLLQKLFVSNGAVSENTASVRTSEQYPKTVDSSTDQRVSYMDESKCAPSTVGSWSSIGSTGQAKMIGGNDIARTRTDNDSTPPSYAYTHPSPPGNRTQNEHQGGADVSQMGRRGLLSENTSLFQRWPSYVEPTNSQVSLAEDMNSILKHLQYGLSNQVKGLDLTSNQNKLPDDPVTFTTHQDSSLNSLNGASASGDTSFRHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FXY2</accession>
    <name>A0A3P7FXY2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020501">
        <property type="protein sequence ID" value="VDM32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FXY2"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="45" mass="4992" checksum="E26372CC51CBBE6C" modified="2019-02-13" version="1">MKGTLKGFDNVINLIVNDSHERVFSPDRGVERVPLGLSIIRGQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G287</accession>
    <name>A0A3P7G287_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021753">
        <property type="protein sequence ID" value="VDM35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G287"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="488" mass="54282" checksum="AFEC9FE00DC3529D" modified="2019-02-13" version="1" fragment="single">MASIEWACKELYTTGDPAVRVQAEKTCTGICERPDCIATCKSLLERGDSCYSQFIAASTLTKYISNRDTVVHVGLRLQLRNFALNYLATRPGLESIVQQALIALICRLTKIGWFDSAEDGPEYPFRDIFESVKNFIQSGQISAILVGVKLLSSLVTEICQSTETDLARATFFVRKLLVSFRDLVLFSIFQMGLDLLRQTDANLKSLTAIDQDQLQVIQHTLALVLACLNYDFVGTAIGCAGDNGSGSPCTSDDMASVQLPAAWRPIFLDANNVDLFFRLFAGLPQSPTSPNLRILITSIRRTLFTNDERQNFLSPLMVGCLEVLRRRDSLLCDPTVYHEFCRLLSRMKITFQVGELMQVSVYPEFIKLVADLTTHSLYKIEARSVVAPQNLNDSPDFSNSNSLHYLLALWQRLVASIPYVRLSQPYLIDTYAPQVTRAYIESRLARVPSYTESGSKVKLVRPVKKSSASGAGVDKSGNQYSLDLTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G9A7</accession>
    <name>A0A3P7G9A7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000332">
        <property type="protein sequence ID" value="VDM18065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G9A7"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="120" mass="13484" checksum="BF4A6F9123B81DBE" modified="2019-02-13" version="1">MKYTDAVYDACMEAFDCLPLAALINQQFLCVHGGLSPEIHSLSDIKKMDRYREPPTHGPMCDILWSDPTEDFGQERNNSHFSQNSVRGCSFFYSYAAVCAFLQANNLLCLIRAHEAQDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GML8</accession>
    <name>A0A3P7GML8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003415">
        <property type="protein sequence ID" value="VDM23918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GML8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="287" mass="30577" checksum="A399BE913A2DA80A" modified="2019-02-13" version="1">MVRLLLYAVRKHSVSPPSLTMPLLLATSLCHVVVTWEQRTRDTRMFALERFCLRGSRLSTTETEGGYSEAANGLPTTPTKRIPTTSSPFPSMLPIGTELTSHNLSAYCLVDETGCAVAQRKAFHLACQLWAAGGISTRLVLKRTSDPLEMASELGAIFAVRICLLTGNKLGALTYKTWHLYGDRPGGEASQFSEPSAVVAQVRYALSGADSSGSHSSIAPSSVFLASANAPTTTGVGDNLAAAASFSSFVTTSSTAISSSVSLSAPPGMWISDEGDERRGNWLRDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GRG5</accession>
    <name>A0A3P7GRG5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="7">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01003924">
        <property type="protein sequence ID" value="VDM24435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GRG5"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM24435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="273" mass="28738" checksum="4C4C0726AADFE835" modified="2019-02-13" version="1">MVREISAYWCVRSGNGVGGGVAGSTSVGGSHLAGGSDARDAETAGGAASGAEIESAAAARRRAERALAEQRRADLELLEARRQQRKLNFLLTQTELYSHFMAKTMSGGTAGGDGRVESILERLQEGPKVSDEAGNAESTLAEAAKAAAGRLGINVDDEFDAEALKAQALSRVQTAIERENQARSEFNQSGQHPMETEMDISKPPALFKGDLKTYQLKGLAWLLTLFDQGINGILADEMGLGKTVQTIAFLGSLAELLTNVDADEGPTAVSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJ19</accession>
    <name>A0A3P7HJ19_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021031">
        <property type="protein sequence ID" value="VDM34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJ19"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="784"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="906"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="983"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1187"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139458" checksum="2133B85EFF71B8DD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHS1</accession>
    <name>A0A0R3WHS1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS109</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000007">
        <property type="protein sequence ID" value="VDM15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHS1"/>
    <dbReference type="STRING" id="6205.A0A0R3WHS1"/>
    <dbReference type="WBParaSite" id="TTAC_0000010801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000010801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000010801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039908at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="103"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000010801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19492" checksum="0B09B5B439A03FCE" modified="2016-01-20" version="1">MHRPHWLPTLQKVDRRTTTHTTVCVCDHLTTFGAGWLVPPNQIDFNYVFRNIQFERNATLYATEITIAIIFLLLFMWARRMDNRDIQKLGITPLAENNPADEYLYEVIVCTGIRRDAGTTSTVCMQVNGERGGTAPFTLRDPHRKVLQRGNVDRFLLATARSVYLVFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI07</accession>
    <name>A0A0R3WI07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS202</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI07"/>
    <dbReference type="WBParaSite" id="TTAC_0000020101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000020101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000020101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265343at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000020101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22804" checksum="19411EE1DD4BD164" modified="2016-01-20" version="1">MLKPEDGEGKGQEAKSPPLSTVNPRSVEMLDGFVKRLTSANEMLALSVAQLSVLVDFELQGLKQIYAELGMPQMPDDTSADEWLLAIHSGAFPSDLGEDTDEISNATQGDTPADEMEVKLEAKMQVRGAPESISPVAPSLPSSPPPQKTVDAFAFFVQHVGATLRRDHGSALRGDVNEAWLEAKLAAKWTSLSADEKHAWQRAAESAYRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIA0</accession>
    <name>A0A0R3WIA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS313</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000023">
        <property type="protein sequence ID" value="VDM16234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIA0"/>
    <dbReference type="STRING" id="6205.A0A0R3WIA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000031201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000031201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000031201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000031201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22061" checksum="89B761097CBD8A9B" modified="2016-01-20" version="1">MVTEDDEVEEEEVEELFGDDDEDEEEGELELEEEVDEEDDEEQDETERLAEVLGVEVFERNNGGSGSADRRSVTTADQQEETNRAEDRKLLALMAHFNDDHLSRFESYRRATFTKSAVSRLIQSVAQTSFSQNVVIAMAGITKVFVGELVEAALDYKEELREIGPLQPKHIRVAYARLNAQERTSRMSCLNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ92</accession>
    <name>A0A0R3WJ92_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS729</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01000085">
        <property type="protein sequence ID" value="VDM16904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ92"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ92"/>
    <dbReference type="WBParaSite" id="TTAC_0000072801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000072801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000072801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="107"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000072801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="717" mass="80335" checksum="5EDCAAAC0E9CA1A4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKC1</accession>
    <name>A0A0R3WKC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1159</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000199">
        <property type="protein sequence ID" value="VDM17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WKC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000115801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000115801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000115801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255323at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000115801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37764" checksum="3AEC6FC639384582" modified="2016-01-20" version="1">MSSDASEINLNASNDARSNTPRDSILQKLPAKQKSIRDSSGYIRLWDCFNQVSQASLVFEIFESADPCDFNQVSEEGTVANELLCVALSMDATRFVTGGSDTIIKVYDLTTRLRLLNLKSGSRTYLTKECTHHTSRISALVYHPRGKNDQLYSHIFVSASWDQTIQIWDDRKVASLWHYYGPQVVGSDGLDIDGMQNIIVASSWVRSGVMLKMWKFADFSITGSSLAAKRKVLQNYSKPVNEVTLEGSDSTTQGYVARMGGEGRYIFYAGYGMNVLKVIDRESMSIVAGLTDLPNAVYSLDSCLDPRDKRRCLIVFTNAKNVYLASVQSRMNFLEVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKQ0</accession>
    <name>A0A0R3WKQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1298</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000251">
        <property type="protein sequence ID" value="VDM17759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKQ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000129701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000129701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000129701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132867" evidence="6">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="244"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000129701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53156" checksum="0B300A2D44B92276" modified="2016-01-20" version="1">MRLVFITMLHGFCVLFLPGQQASEKNKAIYALVARSLDLQSAISDVLAELGVLEDHPHITSSDLPPCAACLLVVVSFDLCFPRRPFGRRSDALKILRKYSQSGKIASDLRRLVKMRAKKVGPRTNSIPRVPLFLRSVEPMDKVIETLGSSGDDIHNQVVYDREKTSYKKFIKLVRNLKKNEFVRDYHFPSLIIVLPPGTDLHLSPVITSNSAVIQDKASCVPPLVLLDALELPRSQPLKILDACAAPGNKATLILSGLKRLAQKGCLMALDRDKKRFKQLCSNLRRMHDGILKVNGVIEGGEVGKKNSGRVICEAFPRDFLTVDPLNEEAFADVKAILVDPTCSNSGLCCKRPELAIQGQEDEAARVARLANLQAKILRHALSFPSVEENEAVVLDLMKSGAAADFELVSIWDTNKNTGQTGSRTGTTAAPKLFAPLAPWKRRGVVEDGNDDASKMMARCLRSSTEKDLTVGFFVACFKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKR0</accession>
    <name>A0A0R3WKR0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
            <shortName evidence="2">SF3b5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1310</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000256">
        <property type="protein sequence ID" value="VDM17793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKR0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKR0"/>
    <dbReference type="WBParaSite" id="TTAC_0000132301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000132301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000132301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000132301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9982" checksum="291AC3E29A4C7E9A" modified="2016-01-20" version="1">MGDRYNIHTQLEHLQSKYVGTGHADTIKWEWLTNQHRDTCSSYMGHFDLLNYLALCENESKARIRFNLMERMLQPCGPPPERTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL96</accession>
    <name>A0A0R3WL96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1521</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000356">
        <property type="protein sequence ID" value="VDM18143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL96"/>
    <dbReference type="STRING" id="6205.A0A0R3WL96"/>
    <dbReference type="WBParaSite" id="TTAC_0000153401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000153401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000153401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="126"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="421"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="781"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="960"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM18143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000153401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115824" checksum="E71938870942EA93" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WML7</accession>
    <name>A0A0R3WML7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1992</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000667">
        <property type="protein sequence ID" value="VDM18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WML7"/>
    <dbReference type="STRING" id="6205.A0A0R3WML7"/>
    <dbReference type="WBParaSite" id="TTAC_0000200501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000200501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000200501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="167"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="407"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000200501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61669" checksum="E3A505605E171914" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNA6</accession>
    <name>A0A0R3WNA6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Na_H_Exchanger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2231</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000869">
        <property type="protein sequence ID" value="VDM19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNA6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNA6"/>
    <dbReference type="WBParaSite" id="TTAC_0000224401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000224401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000224401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="14">
        <location>
            <begin position="43"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000224401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="568" mass="63274" checksum="3C853C68AEA42AEC" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNB4</accession>
    <name>A0A0R3WNB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2239</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000883">
        <property type="protein sequence ID" value="VDM19336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50850"/>
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        <source>
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        <source>
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        <source>
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    <sequence length="530" mass="57269" checksum="FC7BC6A1E72C6C2C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNI9</accession>
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        <submittedName>
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        <name evidence="8" type="ORF">TTAC_LOCUS2314</name>
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    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM19607.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000232701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="791" mass="88427" checksum="1197568308D09211" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNV3</accession>
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        <submittedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">TTAC_LOCUS2428</name>
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    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000244101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22109" checksum="BE2546479EDD1A9F" modified="2016-01-20" version="1">MAAERAEEATTLDFALVAEETFDGANFYEFEALDIDGNNVSMEKYNGKVVIVSNYAQLQELYTQYGSQGLSILAFPCNQFRNQEPGTNAEIKESARNKFGLTFDFFSKVDVNGPDALPLFNYLQNVLGDTPTNDIKWNFTKFLIDRNGVPFKRYAPKFDPKVMQRSLFLSHICLFVRLMAVLLTQRHAFPNFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNZ8</accession>
    <name>A0A0R3WNZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CW-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2473</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001121">
        <property type="protein sequence ID" value="VDM20145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000248601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13508" checksum="3C729C46BBD611C8" modified="2016-01-20" version="1">MRKKSEQTRSVVEEGATRPLGVDAMTQLSGHEAQPYIYVSQWIIRTERKVTNTCTCVDTVRAYLCIDCDSHNPHWCEVDVDEDKVTRPGVTFLLHVMSFHAAGSSGGLRSRSSTLVDNHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP27</accession>
    <name>A0A0R3WP27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2502</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001148">
        <property type="protein sequence ID" value="VDM20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP27"/>
    <dbReference type="WBParaSite" id="TTAC_0000251501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000251501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000251501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10460445at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000251501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12344" checksum="FE74FB1413B9FD28" modified="2016-01-20" version="1">MKGISNASDSAVKWTNLEYERQANPEIVDKLIPAHLSGQVSGTDAPLEDGNGGVGGSVGGRKSSLLESTLTGAAATVRETAPGATLQISETTLPTNEDNAPTRSRHSSGRRSPDTQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP30</accession>
    <name>A0A0R3WP30_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2504</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001151">
        <property type="protein sequence ID" value="VDM20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP30"/>
    <dbReference type="STRING" id="6205.A0A0R3WP30"/>
    <dbReference type="WBParaSite" id="TTAC_0000251801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000251801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000251801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF176">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 101-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="33"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000251801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56806" checksum="5029B1E204F81D30" modified="2016-01-20" version="1">MSTNGTEVTLSNDLPRLLKCSVGVIITSSIIFENLIIIVALLHSKKYLARQTRIFLFNVAVVDLLTGLCIVPALTVVEISNNAYAYAKFFYLYWLTVGGLLVNARVLALVLVALDRYLAICHPIRYPDLLAFSRARLSLMLSWGLAVFMPLPQLAIFSMELVQRSPNATETSLQPHDWTYTTSPALRGLLVFMFFFRFVFPLALTIVVNILAFRVAVESNAGFRNGVLKVKEPDIQTNNEATPPKMPNSIHRPHSLAPNKITVMRIHRGNYMTEGTKDLFAQLPGTHRSLSRRTAVLPNLSLVGSHSAENPLDSGRSLSRINSGTTPSKLQETFKETNSSTSTVRKPPNSDASITPDSENTSTESQSNQKVAWWRSTRSHTPSFRFKFHHKRLKDLGSMIPFTILLFAFLIFSLPYHILQALKALWSRLDLSNEVHAYLYWLTCTNALINPVILTFWSSACRAKVLHLISCGRFHPNQAAIKRLIIASFGTANLPYGRQVHPQMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPE2</accession>
    <name>A0A0R3WPE2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2617</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01001289">
        <property type="protein sequence ID" value="VDM20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPE2"/>
    <dbReference type="STRING" id="6205.A0A0R3WPE2"/>
    <dbReference type="WBParaSite" id="TTAC_0000263201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000263201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000263201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000263201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35656" checksum="AB4F17A378950D9E" modified="2016-01-20" version="1">MMSSFGNRRLEKEEDVFDQNAWDDYEWTEEMEQEARTAVDILSVITLSEEEREGFIVNASTYWDKFYDKHEARFFKNRKWLPREFVELIDGSLCSGPFLSGPPSFPGKDSRFRVLEVGSGPGNSVVPILENRWRGEDETFVYACDFSEKAVSLVKSSPSYNSQYCLAFQQDISKPNLTWPFPPECIDAICCIFVLSAINPDSFPQTIRNLCACLRPGGVIFFRDYGLYDLSQIRVKQGRCIGRNFYTRGDGTCAYFFEQDEVTKLFTDQGLIEKQIRTDRRLIVNRRKRLKMYRVYIQGKYQKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPT2</accession>
    <name>A0A0R3WPT2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanylate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2757</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001477">
        <property type="protein sequence ID" value="VDM21089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPT2"/>
    <dbReference type="STRING" id="6205.A0A0R3WPT2"/>
    <dbReference type="WBParaSite" id="TTAC_0000277201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000277201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000277201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="2">
        <location>
            <begin position="165"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000277201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40407" checksum="8AF303842C74092A" modified="2016-01-20" version="1">MNIASLAQKMLMESSKRGSICDKGMKTARIIHPSTYKPLGPPGLVPSRRRLERQERSKWSLLFGPRSSLLRASSSETGSSIISDPQSTDKAIDSIPLSQSDELIIDSNQSSVAETSTTEARDQQRSANCSRVSKKTTTGRTRSKFTGGTLPPVYIPVASMEAVNTRPVVILGDLKHNISEDLLSEFPDNFSTCVPHTTRHRRHGEVDGQDYHFVKSRSRMESEIQLNRYVEAGEYNGNLYGTHLHSVFKVASMGLHCLLDVGTMALQRLTAAGLPPIAIFVLPTPPTQLKGIVNPSRAITKEEGSFHSRFQKRCEKSFAFLKEHSSLLTAILAADDYDKITKRIYKIVHDNKGPNVWIASGDFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ07</accession>
    <name>A0A0R3WQ07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2832</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001563">
        <property type="protein sequence ID" value="VDM21279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ07"/>
    <dbReference type="WBParaSite" id="TTAC_0000284701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000284701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000284701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6226988at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133029" evidence="1">
        <location>
            <begin position="26"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000284701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="626" mass="71654" checksum="BFCFF2779678A21A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR21</accession>
    <name>A0A0R3WR21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diablo homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3198</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002056">
        <property type="protein sequence ID" value="VDM22139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR21"/>
    <dbReference type="STRING" id="6205.A0A0R3WR21"/>
    <dbReference type="WBParaSite" id="TTAC_0000321101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000321101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000321101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274940at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000321101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="28904" checksum="94195474EF45257F" modified="2016-01-20" version="1">MALCRIIAAASISLHCLLETSKGVYFWIDLKDASTSSTEPPNLATRTTPCITSKPVSKVSAISRLLSCLCCATKRRKSPDAKARSPIGSVDYRLPSFVCPPPSSITSQEPSPDDSDLRAREQALRLAKLAILDAKSNDFYSALASPLSDALVKFLEQTLGVLVLGARVESYCPNDCLPQGLLQPLSAATAVSIVATTYEALERLHDAVTLTAHENSSHLLPASSLSSALETIFQQETELMEKIDLKDIRLSVALQADEMRLAASELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRJ3</accession>
    <name>A0A0R3WRJ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002322">
        <property type="protein sequence ID" value="VDM22483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WRJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000338301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000338301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000338301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000338301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10990" checksum="A1ED03149BC8360E" modified="2016-01-20" version="1">MTSVEVATKMLEYYQFYPPLFRGGEESAILQFSKYQSLELTGISRPVSEAIAMANEHFLHCVAENPMRPRVLRVFLEPTPYNQLNYMDYFKVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSF4</accession>
    <name>A0A0R3WSF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3676</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002854">
        <property type="protein sequence ID" value="VDM23134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0000369401"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:monoatomic cation channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133057" evidence="3">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000369401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17121" checksum="D33418A3BD83E32E" modified="2016-01-20" version="1">MFGLIFGLTMPLFIPKVLLYEPEDRQSEAGEESNDSTEQKDEELSEDVESRVMMKRSLTTSLQVGAMEFWAKIKDFYMSPIVRFVYHTISYVLFLVLFSYLLLVDFKVRITGVEYIVLAWVITLFIEEIKQVQFPLTKFRRNIVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSR4</accession>
    <name>A0A0R3WSR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3788</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003060">
        <property type="protein sequence ID" value="VDM23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSR4"/>
    <dbReference type="STRING" id="6205.A0A0R3WSR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000380401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000380401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000380401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000380401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16637" checksum="A3C49B6EF8F36325" modified="2016-01-20" version="1">MCCTVDLLDPLIECSILLITGALAPQRKGCEKLYEALMKVHSAKSCAIRELVVVENVANVLAERVSSVPNTLIPLLAASHSPHSSPPPPPPPTTTTTTKATTTATTTNTTAPDKVIESMQYFLQGIGLGESFLPPAFTPTSSSQPPIVAPKLCKRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WST1</accession>
    <name>A0A0R3WST1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3807</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003090">
        <property type="protein sequence ID" value="VDM23439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WST1"/>
    <dbReference type="STRING" id="6205.A0A0R3WST1"/>
    <dbReference type="WBParaSite" id="TTAC_0000382101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000382101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000382101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF122">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000382101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23654" checksum="C27E86F250A9F3D9" modified="2016-01-20" version="1">MLAAIKTIETGTREEILQHLSQSNLIEHDPDNNTLLHYACLAGNLSAVNVLIEAGFYVNANNVDGHTPICDAAANGSVEIIRALIRGGANVNPLAYWGSPLINAVKNGHYDAMVVLIDAGADVNACDRKGFCPIHVSVKDRFYSAAEYLLMAGADPNKRVRLTTALHIAAELRDLKMVRLLLRYGAFPSPADYRGRRPIDFVEEDSSIYKLLSAYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTU5</accession>
    <name>A0A0R3WTU5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4171</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003828">
        <property type="protein sequence ID" value="VDM24351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000418501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000418501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000418501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000418501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9104" checksum="D3BA77EF74FFAC31" modified="2016-01-20" version="1">MRAHHEEGQQHGIVQLRWPNNQPTRKCPSFLRGIRTADVLGKQEVELHWLLPLLLVQDEQMAHRDGTLRLYLEGGIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU03</accession>
    <name>A0A0R3WU03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4227</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003964">
        <property type="protein sequence ID" value="VDM24476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU03"/>
    <dbReference type="STRING" id="6205.A0A0R3WU03"/>
    <dbReference type="WBParaSite" id="TTAC_0000424301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000424301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000424301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270180at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="262"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM24476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000424301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45002" checksum="87B3ED1B5346657D" modified="2016-01-20" version="1">MEARKFEVVRFISRGKYSLVYEVGYTQGNDNITSTTWALKRYYLQNDSSIQCALRERNILVRIARARKQSPFVGTLLESLRICGSPALVLRKGCGFDLRDLIEIIGLLSEKEARFYACEVISGLEHLHSIGIVHLDVKPKNTLLDDSGHVFITDFDSAYDMTAATGAPRRIDFGGTPLFMAPEVRHKVDITTKADVWSLGILVAVIIYKHVSVRDWLLSGELMLGHVPRATTCLKEFFIACLRQDYTTRIDILGVKCLDFFKGVEWDEVASLKLKPPVLPWKLKVVDSKDSGRHDPHDPIILAAAYSQHMPLADARLQAIYDKHGGRRSMRVPENNKEILKHTLTSERINELFTDFDFTNPHPLPSTHAEDANSTANGDQCVPSEVEQGNPGGCSSNSRCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU50</accession>
    <name>A0A0R3WU50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol 3-kinase catalytic subunit type 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4275</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004058">
        <property type="protein sequence ID" value="VDM24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU50"/>
    <dbReference type="STRING" id="6205.A0A0R3WU50"/>
    <dbReference type="WBParaSite" id="TTAC_0000429001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000429001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000429001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF118">
        <property type="entry name" value="PI-3 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000429001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35920" checksum="35D5604C5DD47C07" modified="2016-01-20" version="1">MGSNSALQWNQSLNFRLTYSNLPLATRVCVVLLQVKRRPGRIMEFPVGWANMNLFDERGYLVTGRRSLPLWRSSFTSPETETTHQLNLAGTVAENPDPEFTLVVDFCHPSSHATRIRFPISRFITTVSGASPSKPTAAIVPSLQSSDSDLRMLRELIHRDPFYELSEQDKALLWRIRDSCCRRLYPAESLPWLVQAVAWERRELVEEFYRLLAVWPRPLPVETCLQLLGVAGLAGGAGAEGSFGDGSGGGYAMAGGRTTGVADPLVRDIAVQGLQARLSNTDLADYLLQLVQVSTSIQQELISGRSTYKTRSLCVTFASWLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU77</accession>
    <name>A0A0R3WU77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Octapeptide-repeat protein T2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4302</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004113">
        <property type="protein sequence ID" value="VDM24639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU77"/>
    <dbReference type="WBParaSite" id="TTAC_0000431701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000431701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000431701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000431701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18610" checksum="B559E5FD19F51042" modified="2016-01-20" version="1">MQRLSWRSRERREAGAGGGAEAGAEVGGGGGAGARRREGKGERGAGAGAGVGVGRGGKGRGRGTEQKEEQEQKLESAEKEVREQREKKEKEKEEQGREREREKEEQELEWTEEEEQAGEEDEKNKKEKEEHVKKVVLVIIIYLTPQTISTFLRMLPQGLRNGKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVG3</accession>
    <name>A0A0R3WVG3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS4738</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01005206">
        <property type="protein sequence ID" value="VDM25556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000475301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000475301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000475301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM25556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000475301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="23892" checksum="0A4D508BF858D750" modified="2016-01-20" version="1">MDYTLVCQVTALTHTHPLGLLGALLQAHAIRRVLAIASASGDSAFHAIDAVRLVDNLCGDLEAADLSAFSFGRPSNFHLNALQQYREKLNTVKKLVMQESFPTISEVVSQLGNGEPAIEAIPTALYIFLQCQKPMPHIPYESLLIKCSIYSALIGNDTDTIGCMACAIAGALVGAERIENSSSPGDMHIPGTILGHVEGLQTINGYCDWLIQRFKTNEHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW65</accession>
    <name>A0A0R3WW65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arm_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4989</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005874">
        <property type="protein sequence ID" value="VDM26009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW65"/>
    <dbReference type="STRING" id="6205.A0A0R3WW65"/>
    <dbReference type="WBParaSite" id="TTAC_0000500501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000500501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000500501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000500501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16647" checksum="3A91F104EF0D8367" modified="2016-01-20" version="1">MRPIFIPPGGNEKTSVVILIMAADPCQRDVTLRILYQLSTEEKYRGQIASSGCLPLLMRSILGSAEDAPNVECLGLLINLACDRRAAQSVGEPRGIRMLFRRAFATHDPLLMKLLRNLSHFEELRVHFGVGRRSIVGWGSRKKAFCAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWA8</accession>
    <name>A0A0R3WWA8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5034</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01006018">
        <property type="protein sequence ID" value="VDM26115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWA8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWA8"/>
    <dbReference type="WBParaSite" id="TTAC_0000504801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000504801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000504801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000504801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18789" checksum="371FB87646BF37BE" modified="2016-01-20" version="1">MKSKISALRQSRPGSFQNIACIRTNAMKYLPNFFKKGQLEKMFFLYPDPHFKRHKHKWRIISLALLTVYAYVLRPGGRIYAMTDVPELAEWMEEKMEAHPLFRRCYQLSLPINVEPSESLESAKAEDAVVGLLASGVTEEAQKATRDGRGATISVFERIPNPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXN9</accession>
    <name>A0A0R3WXN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">rRNA N-glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5513</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007809">
        <property type="protein sequence ID" value="VDM27135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXN9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000552901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000552901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000552901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM27135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000552901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28409" checksum="86628BD2D749A6C2" modified="2016-01-20" version="1">MPKRRAVKGDDVPPKRTKCYSMNNERHKEVSALIDSTFLLKCPPEFYEFYAFCCSIFPDSPLDALYRDIGIRLVGPFEVLHEPMKFKLDDDFTDCYRYFHDPPEMVTILAQDGENPFHVGYFRGDYADQPSFLVSSNPSETGKLTISGRNIFATVLKLLVESKTRSGSTLPSLSKLREFAKGRQICVDSRASVDWKPTCETLNGVGFKIDLQNGVGYRPVPTTHSKFSTIVARTLSLFGMIVIAFGGYGCTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYI7</accession>
    <name>A0A0R3WYI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5812</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009164">
        <property type="protein sequence ID" value="VDM27708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYI7"/>
    <dbReference type="WBParaSite" id="TTAC_0000582701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000582701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000582701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000582701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10642" checksum="89E8428BC4A11B16" modified="2016-01-20" version="1">DVEVRERRSQTHQCRPHAYSTYAYDVSVVTVTAMVVMVVVEVEEAKVKEKQEEEDEDEEVEVEWEWSEVGCGVVWCGGVGWGVVKMGRGLYSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZG4</accession>
    <name>A0A0R3WZG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FXYD domain-containing ion transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000618301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000618301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000618301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000618301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20422" checksum="C750306175C75384" modified="2016-01-20" version="1">MDSLISGLNRHSLSQVTCRASAELTGCESIRREGHTAYQTEEQNHGDQTMNTKVRDVAILATAICLISLSLILTTTVAKEVGKLELLMQILRALGLLCLLIALITTPFPVPGCTEIERQLRIREIFLLLGSSLMCLVLAIGAVSQPSHMQFWLYTGILFTIISTVFSGSSSTGREETQPEVKEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZS3</accession>
    <name>A0A0R3WZS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6299</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZS3"/>
    <dbReference type="STRING" id="6205.A0A0R3WZS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000631401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000631401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000631401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="393"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000631401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="53916" checksum="AD8F369A6996694B" modified="2016-01-20" version="1">MVSDVIKDGPLGCQTTSLRKSSICSVAVIADTAALGQCSKPLAVGICSMDIDEFKAAGDEDKAIHILHTLNDKLIELCPPHLLESYRLRDTIELKYTEPTVSIGAPNSEATPNDDSPELDMDNLLMFCFLYGLRKLKPADLPLPVNVFYAKHMKKDWYAPLVAPNGREVDVRKTSFKKLGVFLEKMAAEGIISLETVDVGITRLTAFKKDHPVLQELEQNFPELAKSSADADDSSIGTKFVVGDFYFGPPVLKEIRIITPRIAPLFVSAGYRYHFWFFNKLRCVRAGDSIEQSIICRVVGAYIDSNNLRSAENSDLANVDGLLARICEPNLLKESPESTLAEPRFQITFQDLIASLTRGLQVAYRITYPRESGLVPMITTNNKSLKLYLYGAKQNGKDVTRIAGLNNFGIDVKPFSRYIQTKLACSACLTEDPRHGNSVVVQAQGRHVTALSKIMTDVNAVVLDTFGISKKWIEGYEESPKKKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZS6</accession>
    <name>A0A0R3WZS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuropeptide CCHamide-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000631801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000631801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000631801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6224876at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000631801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15725" checksum="E67B42E863B18451" modified="2016-01-20" version="1">MPNSGAIISLNDNTNKGRGVHSVMRAPSTFHVCLLYMLLISFQIHNVQGEMGRSRRSYNAFPLEYRERVKSVGPNVVQKREPQTGGWDLADDLGTLGTGEDFGDINDAVLSSEKTSLTREEIQRYLAQMKAYYLKNGMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X001</accession>
    <name>A0A0R3X001_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6399</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X001"/>
    <dbReference type="STRING" id="6205.A0A0R3X001"/>
    <dbReference type="WBParaSite" id="TTAC_0000641401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8854" checksum="EED74D28BE123596" modified="2016-01-20" version="1">MAGAFLVAYYSIISESSINISNARDLDLLISGLSNIDIDDPRTITTYSKCQSTSPWMERFWQALKFYSTKRVSNFCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X099</accession>
    <name>A0A0R3X099_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SPT2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6522</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X099"/>
    <dbReference type="STRING" id="6205.A0A0R3X099"/>
    <dbReference type="WBParaSite" id="TTAC_0000653701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000653701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000653701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000653701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="50728" checksum="3C96B5638B87CA85" modified="2016-01-20" version="1">MPPLISQSRKDSVGHVPSNTLGEISAKVNARPTFGNKCNVEYTPTPIPKKRPSSLMDALQELSGESVVPSLLKKHKIGVKIPKVARPNPPLPLGVRKECEIPRNNHKSISNNDSSLPTGSNPGAAASRKSFCSKVPSHSSISTPRSTSKVKPSVQKAKDSCITRIAPKRTSQISSSSIVNTNPSIRPNLSTANHSLVLPSTPVNGASLHSKRTGVSPVQNTSANLPKSVQLSSAPSKSRLSEAKLVRPPAQLALQSPSSAFASKPRSLGIAAQIGISRSRIESNLPSQSSVRKTLPLNAVNSVSKAISPSNGKPSIHSAGLPTNGQRKLFGQQPSLQRQITMERPQVVTPTVRGIAAQYGSLPVVVGERSSDAYLDDESDEYASDDSFIDDTDCTSAKDYLRAVKDIHKSLHFDPNKYAKISKYDDLASMESSYRQIEKEEKLSMRLGAREDQEDMAMEAERRRRRLAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N8</accession>
    <name>A0A0R3X0N8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein Red</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6698</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RED family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0N8"/>
    <dbReference type="STRING" id="6205.A0A0R3X0N8"/>
    <dbReference type="WBParaSite" id="TTAC_0000671301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000671301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000671301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012492">
        <property type="entry name" value="RED_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07807">
        <property type="entry name" value="RED_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="8">
        <location>
            <begin position="107"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Protein RED C-terminal" evidence="7">
        <location>
            <begin position="476"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000671301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="600" mass="66617" checksum="E2FD27A379B6CC0B" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0P7</accession>
    <name>A0A0R3X0P7_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">Sel1 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6709</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020317">
        <property type="protein sequence ID" value="VDM30962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0P7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0P7"/>
    <dbReference type="WBParaSite" id="TTAC_0000672401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000672401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000672401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000672401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21502" checksum="A41E0A43B727CBF4" modified="2016-01-20" version="1">MMARRRRSEMLPAYVERVPLARRLKPDTWMTIGIEAALVFMAICAGVFVYYRAHDLSLYATRFYAHMGSSEAQHMLSQYHLIRRDEDPEHAKQAEHWLIKAAESGHGVAAYNLALAHIRGDLPSNSTPEASHLHRLLSQAVSQGVHEALGLLHYCGHGQCLKQQRRRRHQKQQPQDEKRRPPLERDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Y1</accession>
    <name>A0A0R3X0Y1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6806</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020324">
        <property type="protein sequence ID" value="VDM31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0Y1"/>
    <dbReference type="WBParaSite" id="TTAC_0000682101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000682101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000682101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000682101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="704" mass="77108" checksum="31092CB392AB3AA8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X137</accession>
    <name>A0A0R3X137_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6869</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020328">
        <property type="protein sequence ID" value="VDM31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X137"/>
    <dbReference type="WBParaSite" id="TTAC_0000688401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000688401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000688401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="724"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1420"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000688401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1461" mass="160017" checksum="0EDFD3418B6D6523" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1D6</accession>
    <name>A0A0R3X1D6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6995</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1D6"/>
    <dbReference type="STRING" id="6205.A0A0R3X1D6"/>
    <dbReference type="WBParaSite" id="TTAC_0000701001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="73"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="311"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="419"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="684"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="818"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137724" checksum="0E990E7C7FCE4B7E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1N2</accession>
    <name>A0A0R3X1N2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7118</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020347">
        <property type="protein sequence ID" value="VDM31448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1N2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1N2"/>
    <dbReference type="WBParaSite" id="TTAC_0000713301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000713301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000713301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022368at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="163"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000713301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56088" checksum="207AD418AA0D2D9B" modified="2016-01-20" version="1">MEKLGSIFSPISLIKLHLLTTPLYHTTTHPTLPLRLTLNTPSTYTDSDRLKRVESRKREREEVGRCRTYNQLGLPSRVLATSRSWDGKGGDEFLGTFSRKECIQLRVKLAANEKANNLKRKICLHLANATRTCDTHGAWANRTDYSACVLTESPTEAGETLYLQAIFCTGYCFSLLSLLIALLVFQHFRSLHCLRNYIHVHLMITLVIRVVAWLTLYGTTRLNTLVVTYLYNATTSVQAWASLAMLCWMFVEGVYLLNIVYWTFRLHQVRIWHYALFGWGVPAIFVTIWTTIHAVTHPSTRWIEESQDFYLISLPSLIILSSNALVLISIIYALIFRLKVPKNSSPPFPSHDLEVASTRDGKPSWLYVRHRPTSSRSRFRLSTRFNRSESVKSLKACLMLIPLLGIPQVIFIVPYHSSVVQIFTYVNAVVTSTQVRLLLRSTLQNVLLRKHLRRHWYSCQATNRPRQRSTVDLTGKFVVVSGKGASTTGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X223</accession>
    <name>A0A0R3X223_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7292</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020359">
        <property type="protein sequence ID" value="VDM31651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X223"/>
    <dbReference type="STRING" id="6205.A0A0R3X223"/>
    <dbReference type="WBParaSite" id="TTAC_0000730701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000730701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000730701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="159"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000730701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="73542" checksum="29BF4BD0C7E9DB91" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N0</accession>
    <name>A0A0R3X2N0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TGF_BETA_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7542</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020381">
        <property type="protein sequence ID" value="VDM31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N0"/>
    <dbReference type="WBParaSite" id="TTAC_0000755701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000755701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000755701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5948587at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08698">
        <property type="entry name" value="TGF_beta_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF309">
        <property type="entry name" value="INHIBIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133119" evidence="6">
        <location>
            <begin position="25"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="7">
        <location>
            <begin position="373"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000755701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57850" checksum="A2EF5D39707B437E" modified="2016-01-20" version="1">MTISSPMNCGIVLIALALIMTVNCALTHALFRQPPIVEGAQLSGQDQEEEERMWVDAVPKIEVNEENTMDDVETKRTMEEEEEEDREMEAKRRAEEEEFTRQIHIEKFKRTLLQRLHLTAPPDFSRHGGMANRTHGRRMLRSLPLALQGRLLNQMRAEDGAAEPPPDRTDERETLILLKHLHWRLPKVASSTFGIEMADDIDPSRIQSAFLRFETKNPMLKGQQLEVWEIFMSPRDQEEELTNESADRSSSEQYNNLTWMFERQSTGYTSLPAPAVIRGSLSSPIEHRRTGSIRIRPGRLAETFVPSCPGLVQVTFEISGTFAQWMSHRRRMPLMRKLVRSLLVVCPQCSSHVDPVDVNKGILEIHHRNVVRRTRRSLDSNGSHHVPIGNPCSPKGHKFSCCTQPFSLNLEDVGWNNWILHPKTVEPNYCHGSCQADGIQKTPHSDLMHMYRSQNYDHLSEVQREAMLSCCHPVKMASTSVLYVDPDNELHMDTLHNIIVLECGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3I5</accession>
    <name>A0A0R3X3I5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7899</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020419">
        <property type="protein sequence ID" value="VDM32371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3I5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3I5"/>
    <dbReference type="WBParaSite" id="TTAC_0000791401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000791401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000791401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="213"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000791401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42875" checksum="F4521AFE9670D9E0" modified="2016-01-20" version="1">MFPYIFSGKVMTANERMEELNRQISVDYADSVSLKAYFQFCRSMLNMANEFEGDGCKIKAYCLRKRFVILFIDHLSRRKDFMDSEPRVRALWRHECERVLRNVEKAHKEILEEFRAEELSRQKFSSAPLGAIAAAADTTEALRGVGLERRSPLLPESPSVTTSSYPSTALPVTVDSRTPQLPSQKPSTVTPPKIDRTLKPSSVESGPGNGLNPILVPRTLAATFIETVKSNTRANRETCGTLCGHLSPEGDKFVVSHIIICKQTGTADSCITTNEEELLCCLESDGLIVVGWIHTHPSQKAFMSSMDLHCHLSYQLMLPEAIAIVCAPKHDEVGYFSLTPDYGLKFVLDCKETGFHNHTSLQELYAPSTHVVFTEGEVEVVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Y9</accession>
    <name>A0A0R3X3Y9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8077</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020442">
        <property type="protein sequence ID" value="VDM32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Y9"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Y9"/>
    <dbReference type="WBParaSite" id="TTAC_0000809201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000809201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000809201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_22"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
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    </dbReference>
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        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="520"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="705"/>
            <end position="880"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1193"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1193"/>
            <end position="1233"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32570.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000809201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1266" mass="143743" checksum="266F41A34D7E91C8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B1</accession>
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        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TTAC_LOCUS8222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020467">
        <property type="protein sequence ID" value="VDM32738.1"/>
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        <property type="protein sequence ID" value="TTAC_0000823701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000823701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000823701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10421" checksum="8A4A558AA630C42B" modified="2016-01-20" version="1">MVLRLARASAHIGDKCGEYPPPPPSTALLRPPLAMKGTAPIHTVHQPSLHLLLYAPLRASSLTSFFECLFASYHLPFRPQHFAASFTRSTAFSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4D6</accession>
    <name>A0A0R3X4D6_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020472">
        <property type="protein sequence ID" value="VDM32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="WBParaSite" id="TTAC_0000826701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000826701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000826701"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000826701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="997" mass="110101" checksum="1D22832F8C008CD3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4U9</accession>
    <name>A0A0R3X4U9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8441</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020506">
        <property type="protein sequence ID" value="VDM32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X4U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000845601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000845601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000845601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="9"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000845601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62957" checksum="E77B04017E875A61" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4V3</accession>
    <name>A0A0R3X4V3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retrotransposon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8445</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020507">
        <property type="protein sequence ID" value="VDM32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000846001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000846001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000846001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000846001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33846" checksum="FC3C6CDA42474636" modified="2016-01-20" version="1">MRINKDENSAFELGAGWHIRIKKSLHFFASLTSQRPSICPLYAYAVDRGDHSFARHPDEEDQQDCDMGAEFSKHKHKCRKGKWVDKETWTGQNGEAWGPETNLKMVDKANQCVLQWIQSITAEEESTNLDDRPPKRPHSEICMRQFNRSLEALVGKIDLSCCDWLHRIGLWHLESKPHPAVDQSDEVKEASLEGSTPEISSLSAEREGDSEVEAAETASLSSLPDVGPVPEEINKLTEQEAEGNRERGDGTEQNEMVDILTTITDGEESRKMSHQASSIAKLKAAISEHPVKPKPKKRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X595</accession>
    <name>A0A0R3X595_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8605</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020543">
        <property type="protein sequence ID" value="VDM33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X595"/>
    <dbReference type="STRING" id="6205.A0A0R3X595"/>
    <dbReference type="WBParaSite" id="TTAC_0000862001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000862001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000862001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000862001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56943" checksum="34B880C1D2D0A4A1" modified="2016-01-20" version="1">MPKSIKIDQFRYMTNESWRVLMAVEMGMKNHEFVPIDLVHKISRCSRRSSAFLKLLRDDLVPHGYSGYRLTNLGYDYLALNTLTKSGQVIDLGSMIGSGKESDVYLALAGDLCGRQGDATEEKYAAVDQNLRPDLPSKGDYIVIKFHRLGRTSFRKVREKREYHQHRNTCSWLYLDRLAAKREYEMMRMLYHHGLPVPCPLANNRNAVVMSLLMDMVPLCKVLPTILRADDAVLASTLYAQAVDILDNITRNGLVHGDFNEFNLLVHGLVQDGGDDGADVKTATTVATEPKLFLIDFPQMISRNHPTAQEIYERDLNGIISFFSRFLEISPADTPPRSLTDIPRTGHMDVELKAPGYPNQRSQKRNKIGSHRVSMDDSELLVGTVAALALSNEDTGPETDASEEVDSDGDVHDEVSTSNASQASHSEDDDESLLKSNFTTDTNVVKGRKNAQTVLSREEVRERKKREERKRLQNEFRLRIKRQERASVKSKGRAEIATEARLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X623</accession>
    <name>A0A0R3X623_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020628">
        <property type="protein sequence ID" value="VDM33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X623"/>
    <dbReference type="STRING" id="6205.A0A0R3X623"/>
    <dbReference type="WBParaSite" id="TTAC_0000894101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000894101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000894101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="1">
        <location>
            <begin position="796"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000894101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="871" mass="96494" checksum="016BDFEA219CBE45" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6G5</accession>
    <name>A0A0R3X6G5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mth938 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9081</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAMDC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020675">
        <property type="protein sequence ID" value="VDM33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6G5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6G5"/>
    <dbReference type="WBParaSite" id="TTAC_0000909601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000909601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000909601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000001">
        <property type="entry name" value="Adipogenesis-associated, Mth938 domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15811">
        <property type="entry name" value="MTH938 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15811:SF5">
        <property type="entry name" value="MTH938 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000909601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14662" checksum="AB0D7F18A7E25321" modified="2016-01-20" version="1">MASPKILKMSWGSISLEKIGEDGKPVKGEEVVYRDAKAWPGGSCAWDWNKTGTSHWKGITREDVEDLKAKGAEVVVLTRGQWAFLHVPPEIVKELEGLNLKVIVERSPIAMETYNKLVTEGQRVAGLFHTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6T3</accession>
    <name>A0A0R3X6T3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9220</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020722">
        <property type="protein sequence ID" value="VDM33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6T3"/>
    <dbReference type="WBParaSite" id="TTAC_0000923501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000923501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000923501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133283" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000923501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23070" checksum="E293DE0D7A24BF8C" modified="2016-01-20" version="1">MLCRYPLILALILSPLPTASSDSSPICFADYTGLRNTTFSGTAEVLTESYSDGVKVVIKVERILSDPTQALRLHANRIEGYLPSPLCVSAVLIGKQQMWAGSQILDGIAPKFIVQIVRHSEADPCLQKQCHPGAICETWNDIASSMVAVCVCLSLRDLETAGKCQLTTGEVCASDGNIYPNTCSMLRASCLQQTELSIISWTAVNQKDCQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X737</accession>
    <name>A0A0R3X737_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9335</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020766">
        <property type="protein sequence ID" value="VDM34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X737"/>
    <dbReference type="WBParaSite" id="TTAC_0000935001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000935001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000935001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000935001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29231" checksum="B9A0E9337638DAB8" modified="2016-01-20" version="1">MSKCHCGALSTLHPPPSTRHWHDNTLELEKSAGECGGRKKLEAANSDSMSRICVDYSTHQPPSPLAYLTQTHMCEAQLLPLLVNYLLINDETTVHTSHWSRVALCCSVDLVGRGRWGGEEGLECGDLTPSFPTISSTQCIFFPYTLTFVSHHSPHPLLTTIALPHETNYHVDQVEIGRADMQAGKPTCRQAGRQAGGQAMRHCPTKPTPLRLRCCANTASTAKSTAPHASTTHCLRLPSHLYFIHATDGITPLGSLYMRHLVMRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7H4</accession>
    <name>A0A0R3X7H4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9484</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020842">
        <property type="protein sequence ID" value="VDM34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7H4"/>
    <dbReference type="STRING" id="6205.A0A0R3X7H4"/>
    <dbReference type="WBParaSite" id="TTAC_0000949901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000949901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000949901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="843"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="516"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000949901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1242" mass="136104" checksum="E398E96456712D17" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7I3</accession>
    <name>A0A0R3X7I3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9493</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020849">
        <property type="protein sequence ID" value="VDM34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7I3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7I3"/>
    <dbReference type="WBParaSite" id="TTAC_0000950801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000950801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000950801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="46"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000950801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="50136" checksum="BA705A4EFF8C29EF" modified="2016-01-20" version="1">MPVSIFSEPSISASMVEDLEADYSGVFRNVEDVLGRLQNVSPVERYERLQKIGQGTFGEVFKARHRVTKQHFALKRIRIEQEKEGFPITAIREIRILQSLQHENIVCLKDVCYSTRDERSCFRPQFFLVFEFCDHDLAGLSQRADFPNSVKKAIMLQLLKGLFYLHKNNVLHRDLKAANILINRQGVLKIADFGLARRTVASIRPDRPPRYTGRVVTLWYRPPEILLNDRNYGKPVDMWGAGCIMAELWTKYPIMQGENELGQLKLIINLCGSINSEVWPGVERLDAFRDAQLPRDIKRHVRERLKDKVSSPSAIDLIDKLLVIDPSKRFTADQALSHDYFYEDPPPGDLRVFSREGTSYLEFFSNPRHVRGAQQQQHQQLPQVHHNYHGGHHMGPHQRPGPYQYHPVAGRVPMGQIRRPLIQEDNIHHDRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7J7</accession>
    <name>A0A0R3X7J7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9507</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020853">
        <property type="protein sequence ID" value="VDM34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7J7"/>
    <dbReference type="STRING" id="6205.A0A0R3X7J7"/>
    <dbReference type="WBParaSite" id="TTAC_0000952201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000952201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000952201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994231at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000952201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16923" checksum="8A3294309444F94F" modified="2016-01-20" version="1">MKKTLRSRGATNKMKPSNGSSSSKCKSRRSIFKTNPTKLAPPRAFVRLESRIQHKGKWLQTGDIVSVTDVEGGEYYAQIRSIIVDNSEDASVVLTWLIPTFEARKGEFDPAKYVIGMEEDLPRSIDCVNFLCHCPSDYFRPTDSPYTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7J9</accession>
    <name>A0A0R3X7J9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020854">
        <property type="protein sequence ID" value="VDM34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7J9"/>
    <dbReference type="WBParaSite" id="TTAC_0000952401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000952401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000952401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10274690at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000952401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33965" checksum="D888E7FA9CE9106A" modified="2016-01-20" version="1">MVRLGFMEPSEETRASDQKQDVSNSTAGAEQNPGDLNEISNLSQNPGNVNEASGSGENQDDWNAARPIEWTRVNDIKWADWYLCRLLFTKRKQLSLDLGIPALQYYLDYEKYFQELEMEKFAAEFKQDIRCLIITPFDYKRILSHTMTHYLCHVPVLKSAAPMRLKLDVSSGVPNFSHIWEQYLEEVGGTLVDSYEYEVEIGDKQNHLMPEYDCAIFHGDTCRPGDGCLHLWELFHDISREQVFAITGAKAQDSRSTSNLDFIRNVVMRRGISHESVVDNEANLSLRLVFGDTPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7K1</accession>
    <name>A0A0R3X7K1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9511</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020856">
        <property type="protein sequence ID" value="VDM34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7K1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7K1"/>
    <dbReference type="WBParaSite" id="TTAC_0000952601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000952601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000952601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000952601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49022" checksum="4E494B27341D7A39" modified="2016-01-20" version="1">MPRALEIVAHLISEGKAHDIIVMAGAGISTASGIPDFRSPKTGLYANLKKYKLPYPEAIFDINYFKMRPSAFYTLAKELYPAGKYRPNIAHYFFRLLNQKRLLRRVYTQNIDGLERVAGVPPSKLVEAHGTFATAQCLKCEKSIPARMVKAAIDRGKVARCYRCRGLVKPDIVFYNEDLPAKFWRYRDDIPKGDLIIVMGTSLEVQPFSRLIVATPSNTPRVLLNKHIVGPFKTRRRPKDFVALGDISTLIRELCALLEWTDELENLMRDAELKRIDYIGLSPLNLSAMLRLRSERRQRSDSKSVRNSCHTTTNISSILPNVCLDEEMEMRACMASSEVMPAPVPVGHDDKRRRLISIARECHSAEGMQTLPPSQHRLRGLSVPPLGCNVEESGEGGQITDELKAKSEIKVNKEAVGLHRHLSELHITTHSGEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7P2</accession>
    <name>A0A0R3X7P2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ELAV-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9552</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020887">
        <property type="protein sequence ID" value="VDM34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7P2"/>
    <dbReference type="STRING" id="6205.A0A0R3X7P2"/>
    <dbReference type="WBParaSite" id="TTAC_0000956701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000956701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000956701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="191"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="482"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000956701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="595" mass="66079" checksum="6DD954C43AEF6B40" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7T9</accession>
    <name>A0A0R3X7T9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2157 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020916">
        <property type="protein sequence ID" value="VDM34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7T9"/>
    <dbReference type="WBParaSite" id="TTAC_0000961401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000961401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000961401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000961401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36028" checksum="2A2BC71BDB50B233" modified="2016-01-20" version="1">MDRRIGYIIIALVAALLFFVAIGYHGWACGDSILSSNCLRFKINEVTGALLLTAGLLILVAGIFLIVLVLTETSWSEIAAAVIAIVAAILAIAGVFYYLDHMGMWSPFIATIAMSLSIALAAILLFDLITGEIGYIIIALVAALLFFVAIGYHGWACGDSILSSNCLKVKINEVTGALLLTASLLILVAGILLIVLLVTETSWGEIAAAVIATVAAILAIAAAILFFVAIGYNDWECGGSILGPKCRQNKVNKVTGALLLVAGLLILIAGVFLILLLFKGNSWGEIASAVITTVAAIFALIGVFFYLDQRRLWSPFIATIAMSLSVALAGILLFELIVHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8N6</accession>
    <name>A0A0R3X8N6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9896</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021140">
        <property type="protein sequence ID" value="VDM34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8N6"/>
    <dbReference type="STRING" id="6205.A0A0R3X8N6"/>
    <dbReference type="WBParaSite" id="TTAC_0000991101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000991101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000991101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265463at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000991101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18962" checksum="E28557FCB8A63224" modified="2016-01-20" version="1">MERRYYKRLRLRHSLISFCHFFISLFIVLGWLHTSVCEVTVLMSRPLGVQCSCRYLSGRWRRSPLIPTCRIRTVHLVDRVTNASVNAHLFLELRCSSSLPSTSTVTDETATAMLCLKPLFSVPTSAYDSGEEEVSSPPLCCLPLQSLITVYRLMHAVLFCETVPCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X946</accession>
    <name>A0A0R3X946_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Striatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10056</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021276">
        <property type="protein sequence ID" value="VDM35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X946"/>
    <dbReference type="STRING" id="6205.A0A0R3X946"/>
    <dbReference type="WBParaSite" id="TTAC_0001007101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001007101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001007101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001007101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32403" checksum="47B63810625DA99C" modified="2016-01-20" version="1">MMESVGYVQSGDGADFECNGKKSGPDGVTFESRKCDYSIYGILNFLQSEWTKMSIERSRWEFERAELQARIAVLQNEKIGCENLKSDLVRRIKMLEYALQQERYKNYSLKYSNEPNADSSNKDGQEASGKRDGLSTTERARLREYLTRIGMKKLSNEMRAAKVKELLGISLNGEVSASESGKLAPTVSSEHRGDVTSAKSGDDPANRHDEAASALAEFDKLVAQQCGDANESVDVDILADSFTVDIMEPPRSWASGDQSAFVDRLKEHYRLGTAFWDSFIPSQLAVPRGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9D2</accession>
    <name>A0A0R3X9D2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL36m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L36, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10142</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021353">
        <property type="protein sequence ID" value="VDM35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9D2"/>
    <dbReference type="STRING" id="6205.A0A0R3X9D2"/>
    <dbReference type="WBParaSite" id="TTAC_0001015701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001015701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001015701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001015701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12088" checksum="1472A6AB2F991879" modified="2016-01-20" version="1">MGPWWLGLGAASVGISPCPTVGTVLPFLKQCLSVPQTFAVRNYKVVGRLRLRCRDCFFERRDNRLYVECKTHARHRQAQIMTEPRTPWRFRRKIWKHVRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9E6</accession>
    <name>A0A0R3X9E6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10156</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021364">
        <property type="protein sequence ID" value="VDM35136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9E6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9E6"/>
    <dbReference type="WBParaSite" id="TTAC_0001017101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001017101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001017101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001017101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25083" checksum="B8D8C4E36B5027D5" modified="2016-01-20" version="1">MEEAARLKHIKIHEEHKGHETMHLEMFLILVFFTFGAQFALMAWKQYRPKSYHLLTLLGMWIVPMCYSSYMLYLRFMTVWFFFSLVTAVMVYLSSCSCISASTPRRVYWWFLLVHKISYAGSVGGYFLVLFSLFIPTLVDPSFAIPVGGLILFYGVYYGLVARDFAEVCTDKMAAHISYFAPTGIPLRRIDPGVCALCTNVMLNGRGEKKYRLNCSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9L7</accession>
    <name>A0A0R3X9L7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10227</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021446">
        <property type="protein sequence ID" value="VDM35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9L7"/>
    <dbReference type="STRING" id="6205.A0A0R3X9L7"/>
    <dbReference type="WBParaSite" id="TTAC_0001024201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001024201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001024201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033291at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="393"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001024201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50759" checksum="AF0F33CDD6100FA9" modified="2016-01-20" version="1">MSWEQLRLKRPTLSPSLLYFLLNNYENGRAIQSARGWYTNDEKALRGNPIDAVNEYARYWQETEQLCTPSRLQRAETPHRPPDLATLFSTVRAKIAVDSFDRVLGEHHQAFRWAALLKGYRPPTLVLKDSGSVCSSGIRVNSTRLGGQLPDLIRAKHRGSSDSSDVRDFAELNTEVIGSKPDALDAHEIPRPTLSSEGPSRSILTGKPYNYRRATTSELGGVRRTDVQQVVPVPGGGFRSRAGAYELGASSPRLQDWCASGTMSVSRGRTCARRSALRGSGLFGSSLNISQSLDPLRRSQEAQRIHDDWSEFKKSLSHPTTPSTIEPDAETLNGSLSIHPSAVMTQSGHEFNNFSCKEREDSLSSFMDWNLRKSQQSLISVDMDKPIASSVINVQLEKVADETYGLKFVEGHMTRFSQLGVYVKSITPDTPASRGDVRLGDRILAINGKDVTGMTFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAT7</accession>
    <name>A0A0R3XAT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021986">
        <property type="protein sequence ID" value="VDM35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAT7"/>
    <dbReference type="STRING" id="6205.A0A0R3XAT7"/>
    <dbReference type="WBParaSite" id="TTAC_0001066401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001066401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001066401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001066401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30919" checksum="ED5E6F99596A6091" modified="2016-01-20" version="1">MLRGLCYFTEMGWTIRARRPIFLSLSQRRKCGDKQRRDQILRESEALGVLTRNADVQVYLSPDLSKSLREELSSAEVGLVKVKSSVLKDLFRKGSVTMKVVCSINASLHILSNLITLELMSKQLSIEDRGTLPVLEVSPILNANGCAVGSALASPRAKVLKLRTTIDDHMMGVKVRQISELLAKGYEVIVSVRLPPKQMKHLTGTLVLSDEQKLSVQKVSRIPLLAISLAFAAFQKLYESNAQRFMNAFRDCSSKPPKLIQNKDFQEFTIILCDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBE6</accession>
    <name>A0A0R3XBE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRA1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10856</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022381">
        <property type="protein sequence ID" value="VDM35836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBE6"/>
    <dbReference type="STRING" id="6205.A0A0R3XBE6"/>
    <dbReference type="WBParaSite" id="TTAC_0001087301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001087301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001087301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001087301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16662" checksum="EDAD462FCFB002A2" modified="2016-01-20" version="1">MISLQRDELIVHPLCHALLRCKCSAFYINFLACLTFLVLDHEPLRHSANTRLNMTCYNLVRVEMPKYKHFHQAFVPRIDVDFALTSQGLKFFKDLINFYSLGVFAAATAYAVMSLHKVINHNFIELGAIALFLAWSYLVIHLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBU2</accession>
    <name>A0A0R3XBU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11002</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022714">
        <property type="protein sequence ID" value="VDM35982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBU2"/>
    <dbReference type="STRING" id="6205.A0A0R3XBU2"/>
    <dbReference type="WBParaSite" id="TTAC_0001101901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001101901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001101901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001101901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57733" checksum="1722B78EA3EEE617" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBU9</accession>
    <name>A0A0R3XBU9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11009</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022729">
        <property type="protein sequence ID" value="VDM35989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBU9"/>
    <dbReference type="STRING" id="6205.A0A0R3XBU9"/>
    <dbReference type="WBParaSite" id="TTAC_0001102601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001102601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001102601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001102601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="30969" checksum="947F51ECF6D44721" modified="2016-01-20" version="1">MQFWLCFLTYRAHHQQSLLSSDRNSLASDTHPLPQTIVHDIASSQGQPPSLPSFQPEVPPGNDTNLQKHEPAHEQYQEPLTPHRTPSSPTAEQSVSSHQAFFVPSLNPSSVNTVSAASEISGYDYFAGIATSQISRSRTVSMASSHDSSTVASSPSPSSRTVSPSSSTLQPQTARRISNSGSLLRDQRSRNAASRASPVTTSSGGAVSESKRGQPAFTTAPPQPISKTTSADNHRQPLEQSPMQNPQQEEKSGSTPGKSGWFSGLFGRMKGGGQEIYLPDDSNPSVSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBV1</accession>
    <name>A0A0R3XBV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RFXA_RFXANK_bdg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022735">
        <property type="protein sequence ID" value="VDM35990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBV1"/>
    <dbReference type="WBParaSite" id="TTAC_0001102801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001102801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001102801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001102801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19016" checksum="DDEF3CDFBEBAA854" modified="2016-01-20" version="1">MKKKSHEESSEAASKEECNVQSERTLSQPDEENAMCDAKGWDGSEDRKLREYVLSVAQKYYPHLVKCMQQGDANQAPSDVLGADEETDAKHSPKHNLTLCHAHSAACIHQCEGTQPPSGVRSTDAAIHGGPCSIHSLCLCHLQPSICSHHCEATQMPSNALGDDEPPLRGQSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBX7</accession>
    <name>A0A0R3XBX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022781">
        <property type="protein sequence ID" value="VDM36017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001105401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001105401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001105401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264499at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001105401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21745" checksum="BDE2117059479526" modified="2016-01-20" version="1">MALIKRPISPHHQLNFVXXXSCSSKACINAFSRLHKFTHPXXXXLRACLVTNGKATCVRKGFNIRLPTELADRVANGDSSTALILKDHVFNSSELVLNFRPPFPGSLDKPEVFTKVGVRSVQWRIIAYFVLILEDTSTHPTGSKRIRAIGSCCLGSNAQNTTTTEDLSILTDGILPLLPSVTSETSQRLVSQWLHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC57</accession>
    <name>A0A0R3XC57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11117</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022994">
        <property type="protein sequence ID" value="VDM36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC57"/>
    <dbReference type="STRING" id="6205.A0A0R3XC57"/>
    <dbReference type="WBParaSite" id="TTAC_0001113401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001113401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001113401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001113401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13296" checksum="1D542ADB5AE32CB5" modified="2016-01-20" version="1">MQVGEVGTTYFSYLWLQVIAEYERAVIFRLGRIRPDGAKGPGLFFVLPCLDSLRKVDLRTVTFDVPPQEVLTKDSVTVAVDAVVYYRIYNPIVAVTNVEDADRSTRLLAATTLRNVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCG3</accession>
    <name>A0A0R3XCG3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTP_transf_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11224</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023262">
        <property type="protein sequence ID" value="VDM36204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCG3"/>
    <dbReference type="STRING" id="6205.A0A0R3XCG3"/>
    <dbReference type="WBParaSite" id="TTAC_0001124001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001124001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001124001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001124001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="429" mass="47970" checksum="3063333FD80C6CA8" modified="2016-01-20" version="1">MNLTSFSWPKNTMPLAFTMKLRKHIKNKKISDIQQLGIDRLVDITFGFEQYAFHLLVELYGKGNIFLTDANYIILHLLRARTDADQDVRYATRERFPIELARPIPEALVDLSDSSGLENLTQTVADLLVNASGPWNIDLPAEDAQRLPVTSVLSNAFSYGTGLIEHCCFLAGISTTRRGKAAENSDVDFQIPSDPNACRLEYSSKIARALRDVLSHISGAKSIKDDGSTSTPAVILGVPNPAEPGKLNKYDSYYPLRFAHLSSKPGIEFASFNKAVDEFYSSIEIQRNEVQSIQTAKSANKKVENIKRDQEQRLKALREEQIADNQKAQLLEMNMDLVDKAIMTLNSAIANQTSWRVLEEVLEKQKERGDDPVANCIVRLQLASNQAVLRLTDLYADDEDEEATTVEVLVDLDSTAFQNAKKHVNLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCI6</accession>
    <name>A0A0R3XCI6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11246</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023374">
        <property type="protein sequence ID" value="VDM36226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCI6"/>
    <dbReference type="WBParaSite" id="TTAC_0001126301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001126301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001126301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133368" evidence="1">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001126301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13835" checksum="7140276357A57044" modified="2016-01-20" version="1">MLLCLLLPLILILSLLLLLFLLLPPPSPPFPTPLYCLLACPSSSAYAHFHYPHPTPSSPYYYYHYSLHTPHSPSTTESNTTIFSPSSPPPNSLHLIKTTLPPQSSVLPLLPIHPTSHHLASRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD69</accession>
    <name>A0A158RD69_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD69"/>
    <dbReference type="STRING" id="6205.A0A158RD69"/>
    <dbReference type="WBParaSite" id="TTAC_0000000201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000000201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000000201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051736">
        <property type="entry name" value="DnaJ-B11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043136008" evidence="2">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000000201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43909" checksum="14F0A83C5EA1F971" modified="2016-06-08" version="1">MRDSVSLAVLLLLPELVLSQNLYEYLEISSSATESQIKKAYRHLAKQYHPDKNKDPETETKFKQITFAYECLSDPVKRRRYDSGQGIKACEGDGGGDNFGDFGFSNIFSTMFGGGSDMRHGEDKLRGADIIVDLPVSLEELYNGEFVEIVRSRPVKKSKPGTRECNCRMEMKTQYLGPGRFQMLQQRVCNQCPDFEFVTEDRQIEVEIEPGAPDGHVYSFPDEGEPHTDGDSGDLKFVIRQRKHPVFHRRGDDLYTNVTIGLTDALVGFVFELTHLDGHKVLLKQNQVIWPGAIMRVPNEGMPKYDDNAKRGNLIVTFDVVFPRNRQLTTNEAEAIKSIFNEGTKASEKSVIFGVPTKRPEGLSEGHTSPIVYNGLLSKSAAEKHLPNTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDB0</accession>
    <name>A0A158RDB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GLMPA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS259</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000017">
        <property type="protein sequence ID" value="VDM16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDB0"/>
    <dbReference type="STRING" id="6205.A0A158RDB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000025801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000025801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000025801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043135977" evidence="12">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000025801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45534" checksum="8C2F831CC667B567" modified="2016-06-08" version="1">MLLLFMTIAVMHVRWSSTQSLSASLNPGCNNCSNISVVSVVFREQSSSVHFIVSITKENSVPSVFVSRSDSNSSVYFDWPSIFSNEPGQSVVLSNSSFYGLLFSNLYQYEDRSDVADISRAAGSVTKYPLNHCFWFLSRWDPLPDSTTGLLSLALRCNDSRPSVIFASKGFIELEFTFSEKDRLADRAPHTLLLGGLAVRVMVVLQRLALQWKETRWALNLAIVANRSLPDSAVFENVTLRSIDDEPSPGAFKDMTVFLTNHSYVTWKSVCYVDAAAANVKSSRAVAVSPQLCVDKGTNRSLIKSSLFPFVYGAVANTVAVRQVNVSFGDSGDGFYRSSNYIDWSFAFALNTPPPGYYSPLIWTMVVISIILISAAACLLVYLIGYHFITRGSDSLVRPLLEQVDDSNEQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDN1</accession>
    <name>A0A158RDN1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carn_acyltransf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1018</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000157">
        <property type="protein sequence ID" value="VDM17318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDN1"/>
    <dbReference type="STRING" id="6205.A0A158RDN1"/>
    <dbReference type="WBParaSite" id="TTAC_0000101701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000101701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000101701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="275"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000101701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="647" mass="74303" checksum="4EA30BABA3A384A1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDT2</accession>
    <name>A0A158RDT2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6049</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDT2"/>
    <dbReference type="STRING" id="6205.A0A158RDT2"/>
    <dbReference type="WBParaSite" id="TTAC_0000606401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000606401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000606401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="284"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="437"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000606401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112905" checksum="62DD4BC480C672DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDY6</accession>
    <name>A0A158RDY6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDY6"/>
    <dbReference type="STRING" id="6205.A0A158RDY6"/>
    <dbReference type="WBParaSite" id="TTAC_0000634501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000634501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000634501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="451"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000634501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="774" mass="85140" checksum="3CFB46BA1CD36095" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB8</accession>
    <name>A0A158REB8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps39_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7028</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020339">
        <property type="protein sequence ID" value="VDM31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REB8"/>
    <dbReference type="STRING" id="6205.A0A158REB8"/>
    <dbReference type="WBParaSite" id="TTAC_0000704301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000704301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000704301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118411" checksum="CA035E969FC2EA4D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REE3</accession>
    <name>A0A158REE3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40S ribosomal protein S27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7120</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020347">
        <property type="protein sequence ID" value="VDM31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REE3"/>
    <dbReference type="STRING" id="6205.A0A158REE3"/>
    <dbReference type="WBParaSite" id="TTAC_0000713501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000713501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000713501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000713501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="592" mass="65185" checksum="D206013D7D56B3B8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REJ4</accession>
    <name>A0A158REJ4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7383</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP45 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020367">
        <property type="protein sequence ID" value="VDM31755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REJ4"/>
    <dbReference type="STRING" id="6205.A0A158REJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000739801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000739801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000739801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033253">
        <property type="entry name" value="CFAP45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504">
        <property type="entry name" value="NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="9">
        <location>
            <begin position="37"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="190"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000739801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="46835" checksum="33C1572EF10B73B0" modified="2016-06-08" version="1">MKKLDMERRANEKLNELEEEARQKAQYLLSKAMEQRQDEEEEIKQLNAAITNAKIQTIRDAQVMEKQQIKKELAEENERLDRMMEMDRQNALQVQAAIEAKRKEEEMLGACEIIKQINQNEQERLLRLEKAEQENMAARKKIASEMLEEMKCRTDRKTKQQLLREELDKCTDLARKMRLKKAEEERLLDLKIMQEQKAKADREAAFEEEQRLIRYEKESETNRLRGLQERAIDLQAEKDALRAKRAMEENERQWRRKELAAARRAQEAREEMNRERIRAEENKIRLLAMEATRNKMDFERVLQHQKELIEKDRLEEERRNKMKMEFCNDLKKQICEKEQQRIAERNAFFEEGVRMEEEARLRRLRLEDAKNRKMEELRHVDVHILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REN3</accession>
    <name>A0A158REN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7643</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020390">
        <property type="protein sequence ID" value="VDM32059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REN3"/>
    <dbReference type="STRING" id="6205.A0A158REN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000765801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000765801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000765801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000765801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="54134" checksum="A7D03D2CFE44CF0E" modified="2016-06-08" version="1">MYADLQNAFFVSPSSSFAFDSLREAIDLTTSFSGHSRPTLPPPKASKPGAGTSLLCSPTNEISQMNASPFRPKYPLNLFTKSYCNGPETRPKVELPFADEGQPEIQRAMMALEAESTFPVNGRLWHYPDGMLVMNRGGQCHTSLQKRSFRPVKRNRRGDSPTHTPHLHPLPIPPPFLFPGPPPPAPAPPPPPPPQPSPMSQVSLGLHPGPLDLAQQFFTSVAIAPNPNAPQSGEISVMEELVSCRLCSKQFTTQHGLIVHLRRSHKEKNLLDCETSCLQNSRTNDVCELTRRGGVNEGAVTMNERSFHCSHCGKAFKRSSTLSTHLLIHSGTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPYKCNLCGKEFSQSSNLITHSRKHTGFKPFSCNFCSRAFQRKVDLRRHLDTQHNDPNSISTVGTGASVVGVIKKSPKEVLSTRSSIKSVSTTDFPSAQRASTVELSKSTTTPEAASASQFAYSIERILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EF36</accession>
    <name>A0A3P7EF36_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000408">
        <property type="protein sequence ID" value="VDM18296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EF36"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="604" mass="65763" checksum="A09F20D5EC2A291D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERC1</accession>
    <name>A0A3P7ERC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002283">
        <property type="protein sequence ID" value="VDM22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERC1"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018004045" evidence="2">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="218" mass="23742" checksum="D4AB82C42510A902" modified="2019-02-13" version="1">MFFLLLLLLPSQDLVAEVLDEYEKRQSKLFYSPNDGMMESEMEMVEEAGRLSFYESENFEDSEDFGATNGLVFPPALNDEGLSRMRSKRRAPLPPPLPPKGEALKAVASVAAARQSCATAPGPITNTTSSASSQQPTHDFGISSVNTDDNDANRLSEGNGEYQTKGTGTGVPPPRPPPPKFDTACGLLTDFEKCGLRHAERQYQMEHGIGLPPTPKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EVH0</accession>
    <name>A0A3P7EVH0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="5">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01008186">
        <property type="protein sequence ID" value="VDM27311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EVH0"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM27311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="183" mass="20748" checksum="FA3F7B22C9AB6147" modified="2019-02-13" version="1">MRLYCSQPNILPESKFAWEPFSVPPTPPSLSLVSPGCLIADSGKLKELDRLLAKLKPEGHRVLLYSQMTKMIDLLEELMLYRGYAYLRLDGSSRLSDRRDMVAQWQTDSRWFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQLKPVRVFFLIYPSVPVSFNVSSLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F1P9</accession>
    <name>A0A3P7F1P9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002559">
        <property type="protein sequence ID" value="VDM22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F1P9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="195" mass="21038" checksum="3262C9CBFF988901" modified="2019-02-13" version="1">MFASAFFFPTSEKTWSTSFISHASRLTVITSSTFASSSSSSSSPSSYAAASTSVLTYASATASAASSRCLVFYLRFTRMSSQRKLSAREHAHMASSSLLLATLLVALECGLVVPAKVVRPRSTTFLSPPTIEVDLCTDLRSVRLGGGDFTVKAVTSTLPTTSSQLHHLSLVHWYHHLLLHLSTTAHDNHATRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F3L4</accession>
    <name>A0A3P7F3L4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01002915">
        <property type="protein sequence ID" value="VDM23209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F3L4"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM23209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="281" mass="31587" checksum="89C6F7EC8D1AE1CD" modified="2019-02-13" version="1">MSGGAAHAKRLEDLQRFQATGATIIVATPGRLVDLVQKAPLFLGQESNNQTFNPIVRGLRSLEILILDEADRLLDMGFESQLNSILGMLPKQRRTGLFSATQTNRLDDLLRAGLRNPVSIVVREKEELSTTHQQRTPLTLENYFLVVDPADKLCALITFLRSHLSTEKIIVFFASCAAVDYFGRLLRNGLLPPNQASLVHVLHRKMRSKRVAEFEKFRSTKKGVLLCTDVMARGIDVPGINWVLQWDPPSNARWISFLSLHLPTFIGSLIVHSEIYVMFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G0X4</accession>
    <name>A0A3P7G0X4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020713">
        <property type="protein sequence ID" value="VDM33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G0X4"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="249" mass="27516" checksum="9885B477C34EF4E8" modified="2019-02-13" version="1">MEVENTGQPYPQLVAVSKTKPPELVIEAYDAGQKVFGENYLACPEIRWHFIGKLQSNKVKLLASVPNLAMVETISSFKIANLLDNAWKRVCSRPLDVLIQVNTSGEEQKGGVVVSELVDLYKAVSSSCPYLNLCGLMTIGRYGYDEISGPNPDFSCLYDCRNRVCDALGLPKHSLHLSMGMSSDYETAVMMFDGEKFPVGPDGKPLKPCCACPDTRKARDECIVQRGEENCKDLIEAHLACLRSLGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4Z6</accession>
    <name>A0A3P7G4Z6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023472">
        <property type="protein sequence ID" value="VDM36259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4Z6"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="244" mass="27791" checksum="42023B3284DA0FA1" modified="2019-02-13" version="1">MKDASDQSQVINELSRQLEAAKTTAQQAAVEAENAHRQAAAWATEQSVNSEQSQRDREAMAALKADLQDTLKAKDAAEKRIERLENDLQNQIKALNVAVDQAHTIEEVCKQEHLTLIDSLSRENQDLKVALNEANQAQSRSASFDEPASQSLKKEVDVLKKELDKRDVVITKLEKECQEKHVRKLEALQVQLRRYEEETANLNRVLDEQRKGIEERDRLVRQLRAENASFVFCVPLNYIIHVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G803</accession>
    <name>A0A3P7G803_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023878">
        <property type="protein sequence ID" value="VDM36367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G803"/>
    <dbReference type="OrthoDB" id="6273170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="48" mass="5474" checksum="F5D9CAEEB12B265B" modified="2019-02-13" version="1">MRVHLSSRKEEWEMVVQKAVEWLEGSGVNAEAVIEKARVALEKLLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G8E0</accession>
    <name>A0A3P7G8E0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000708">
        <property type="protein sequence ID" value="VDM18782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G8E0"/>
    <dbReference type="OrthoDB" id="419432at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="530" mass="59863" checksum="AFD446D94FE2ED2A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GE64</accession>
    <name>A0A3P7GE64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001467">
        <property type="protein sequence ID" value="VDM21068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GE64"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="316" mass="35372" checksum="7D87B450C1D1A4DD" modified="2019-02-13" version="1">MTAIERFGKGCDQTPNKSLSIQALIKELNACERNSFLRLWISPTDNKGTIQVVCSRSLFVVFDEVIQLIRLPSDVRVIELFAKVEKFTSGRSPFDGLIEGYGKLLLKSNYTTLRMEDEKYRLFDATLRGNVSLDCQSSHVVACVYGPLFQLELVHMSCFPPELPGASEASMPTYASVGGFLVLPILLRTGSCLWRHRYHSRRHCTVWRRVETYTKSLLLGRHLRTPPLPTPLLGGSKNRHNVVASTKEVGALECAKLRRTGWLLSARSLRLEGRIASGRYGDVVRGVLLASLSREKHEPPRPIVAKMLNGAVGYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GS81</accession>
    <name>A0A3P7GS81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004161">
        <property type="protein sequence ID" value="VDM24695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GS81"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="108" mass="12593" checksum="6DEF00F52402D3FC" modified="2019-02-13" version="1">MLQVLSVFSEESVPFFGPTIPTSREFTDHEELRHFLLVKRECFAFVRGKFHRFFIADKRLTRDSLVGISYLLSSEAQLFSSLKRNFGGTLMEVVKWLLIVTKVTFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GXP7</accession>
    <name>A0A3P7GXP7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007101">
        <property type="protein sequence ID" value="VDM26745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GXP7"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="126" mass="14715" checksum="C9EE2DB50808181B" modified="2019-02-13" version="1">MAKYNELKLKKTCRYILYKIEDQKEIVIDQIGDRNCTFDQFKAELENLEKSARYAVLDFESDNNKSHLLFISWIPDNASVRERMLYASSVDALKSQLTGFKSYLQLNEKSDLTKENFMDSLPGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HFF4</accession>
    <name>A0A3P7HFF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020510">
        <property type="protein sequence ID" value="VDM33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HFF4"/>
    <dbReference type="OrthoDB" id="6257905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="354" mass="39251" checksum="C9FE65032EC0E1AA" modified="2019-02-13" version="1">MNLDPRGSERNSNSPAAPLLSSREVFQPLSASELMAAGNATVCRRVQGVYRARTALLGERASAVVALIDRLNARLHTLTAENRETRAHFSLSQSARHNSPYLVARYVTATISVREQEQSTFCYTPYLRPFHRFDHLIGILSSTVSLWLTLILVVKMHRKNFRDRRAQLLGLHRLPLDVGAPIDVATSAASGHENNANPLPEEAYDHCNLAASQSMPPKLIQLGEGGTWLSRLLLYPLSTLHSPIDVLIMIKLFFPGCDIDGPNWFAGAIQAVGQLNARPPRDPPEMWLTVPTSMFEMTSHSLQTPKMPPTIFYNRRISQKPLKTTCGHVALLEPSASASSSTQTVILDNLQNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI92</accession>
    <name>A0A0R3WI92_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS304</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000022">
        <property type="protein sequence ID" value="VDM16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI92"/>
    <dbReference type="STRING" id="6205.A0A0R3WI92"/>
    <dbReference type="WBParaSite" id="TTAC_0000030301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000030301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000030301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000030301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25640" checksum="499AA05C705C813D" modified="2016-01-20" version="1">MAIADIVQHDYIFKLLLIGDSGVGKSCLLLRFAVRYLRSTIRHLKDDTFYENFSSTIGVDFKIRTVDLDGHHIKLQIWDTAGQERFRTMTVAYYRGAHGIIVVYDVTSEESFRNLGLWMEEIKRHARSDVIKILVGNKSDLEDRRKVTYEQGAEFANLHGLQFFETSAKSASRVEEAFFSMAEQLLKAFRQQRQLQMQQQSQPIIITQTEPVKASSQSTGYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIB2</accession>
    <name>A0A0R3WIB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase family 16C member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS328</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000025">
        <property type="protein sequence ID" value="VDM16253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIB2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000032701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000032701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000032701"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000032701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37105" checksum="E91D74F38F29B786" modified="2016-01-20" version="1">MWLTLISLAVSVCVIFLAYKYLGKKPADLSNDVILITGAANGIGRLLTILLSEYCHTVIALDKDIIGLKETALRVSERYNSDLIFYECDVSDRNAIKMCAEYIRRVHGRVTVLINNAAVVNGNFLIDLPSARFEKLVQVNFVAPFYFLKEFLPGMLGSTYKTAMEHIPQQLRVIPTKSNVKRCFDEPPRGHLVFLSSLASQTICSGLGDYCGSKAGLSSLAETLRLEMEVLGMSESIAVTEIRPFAIDTGLFEGFNSKLPILPILEPEKVAKRIIQAIRYRERTVYIPWIIWFVPLLQRILPFSILIILYKISGAFDGMNTFKRANKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIC2</accession>
    <name>A0A0R3WIC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS340</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000026">
        <property type="protein sequence ID" value="VDM16274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIC2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000033901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000033901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000033901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="522106at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="511"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="622"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000033901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="785" mass="88921" checksum="7C83B25650449016" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJT8</accession>
    <name>A0A0R3WJT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS955</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000140">
        <property type="protein sequence ID" value="VDM17226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJT8"/>
    <dbReference type="STRING" id="6205.A0A0R3WJT8"/>
    <dbReference type="WBParaSite" id="TTAC_0000095401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000095401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000095401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229058at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51364">
        <property type="entry name" value="TB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TB" evidence="11">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM17226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000095401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="48712" checksum="CFCE018DBF1335DB" modified="2016-01-20" version="1">MIRRGPNVCGTFYGLTLCCKGWTKSLDGLCTTAICDGNCGDRGSCIAPNQCRCEDGRVRDDCLVEDDNGYLADEPIRCPSNCNNQGSCVNGKCVCDFGFKGSACDEEEVGPCFIQTERGVCKNKVTGPGNETVMLTRNACCGSIGVAWGALCQGCSSQSSYCGKGYIRLDHKCVDINECEIPNVCMGGICRNTDGSFDRIPINLTDGCQKNPEACTPGGRCIPLHGTAYICQCDPGYVATDGNTRCRKEEVALNYCEIFEGRLCKNGECHPTASSYECTCNPGYVPSRFKKQCIKEFNACTLYGNSVCTNGQCIPVDRSFRCICNPGYVLSGDGTACLASKREPLNTGNNYRASYQADWPQENRAYQSAKPQTGETRWQPSSRVNYPNPCEDIAVKRKCMGGFCINLGRGNYECRCYRGYRPVNGSQQCVADYRRPSREFHRTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK13</accession>
    <name>A0A0R3WK13_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1040</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01000163">
        <property type="protein sequence ID" value="VDM17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK13"/>
    <dbReference type="STRING" id="6205.A0A0R3WK13"/>
    <dbReference type="WBParaSite" id="TTAC_0000103901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000103901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000103901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132929" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="186"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000103901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52644" checksum="6692AD6A6803D110" modified="2016-01-20" version="1">MRGYVLYFLPVFIRACFALYGGDDSVTRLNSENFDNFVSQPGVTVIKFYASWCGHCEGFAPKFRKAAGILQAYFLTILITISLDTGVYVCQQGLVRFGVVDNEAHSDVGNRLNVEAYPTILVFRSDKSPDNPTKYTGPRTTDELIIFLMEQVREFVVARANKEGVQLDLPSRQANAGTGGATCGGSQSHTDARDNHYQNSEAVITLTDQNFDSLVLQSDDDWLVAFIAPWCGHCKNLAPEWKRAAEKLKGKVKVGTIDATVHTTLAGRYEIRGFPTIKYFKSGHIEEYNGMRSSESIVEFGLQKAELNRPPPKVNEITSNEVLHEACDDKQLCIIGFLPQLLDCQSKCRNDYLDVMQEAAKKHRGKDWGWLWSAARTHIELEEALQIGGFGYPTMVAINMRKQKFAVMHGPFAADGVRDFLYDLSQGRGSVSLNSMLALPEIQSSSPWDGKDAPMVHEEEIDLSELGIRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK17</accession>
    <name>A0A0R3WK17_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1045</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000164">
        <property type="protein sequence ID" value="VDM17362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK17"/>
    <dbReference type="STRING" id="6205.A0A0R3WK17"/>
    <dbReference type="WBParaSite" id="TTAC_0000104401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000104401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000104401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="203"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM17362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000104401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="520" mass="60278" checksum="A06FB5D71722C73E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK50</accession>
    <name>A0A0R3WK50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1081</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000175">
        <property type="protein sequence ID" value="VDM17432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK50"/>
    <dbReference type="WBParaSite" id="TTAC_0000108001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000108001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000108001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275501at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000108001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34880" checksum="1EB6AA760F6761C4" modified="2016-01-20" version="1">MQTRNSYCFEYLVTKAKMPRQRTCCPFMQRTLYRVARNLARLDLGFSCPDLEGSSSPTSTATPTPTMKRKASPRKQRHHGRERRLEEIRPSSGGVLNWLVRGTLSRRDPSDTLSSAPPMPRSDIDNETLNEQGDPALLEMEEETTNGEAADHLLLKQKRKLLRRQKIYDMDSSMDVTTSGRVSSTSQVGQNSMDQAYAPPSQAPQATKHHAPAPLRITPEIDDWEREVKGEAGRSHDQIDPSIPLPVSTTTATANTVSTSIAPTVIPPFSVREPVEKQVRSWLESTSDEYDILLKRSVLYPLNFAFRIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK71</accession>
    <name>A0A0R3WK71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1105</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000184">
        <property type="protein sequence ID" value="VDM17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK71"/>
    <dbReference type="STRING" id="6205.A0A0R3WK71"/>
    <dbReference type="WBParaSite" id="TTAC_0000110401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000110401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000110401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000110401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21907" checksum="7B08D924AB9F2AD4" modified="2016-01-20" version="1">MAQNNVSSLNRSYQNLLLPTEGSLEAYILRFLNISANASILHLLRSELTVLQEANRLREPELIALIAVNTTLMIFGAAGALILIAAVARKPRMRTPRTLLTVNLAVSDLTLCLFTQPFNLIRTLHWHYEWRFGEVMCKFTSFAQATNVFVVTMSITVIALERFNVRLTFSQIISPSPPKTSQSRKGFLFLIPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKG9</accession>
    <name>A0A0R3WKG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1209</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000217">
        <property type="protein sequence ID" value="VDM17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000120801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000120801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000120801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000120801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17377" checksum="B27CEF8EC07EC07B" modified="2016-01-20" version="1">MMRIAFYFSSSLVARQPRSIVFISFIPVVYKFVGGDITFNPNIDVKTFKTICEESKGVQLFDVREPRELETDGRIPGALNIPIGEVESAFGLGETDFNTKYGVPKPKATDDNIIFFCKSGGRGLRACKCIEKYGYKRYELVILFFGSTILKFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLD4</accession>
    <name>A0A0R3WLD4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1559</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="11">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01000375">
        <property type="protein sequence ID" value="VDM18210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLD4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000157201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000157201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000157201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12873">
        <property type="entry name" value="SPRY_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000076">
        <property type="entry name" value="ATP-dependent RNA helicase DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000652">
        <property type="entry name" value="ATP-dependent RNA helicase DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000708">
        <property type="entry name" value="ATP-dependent RNA helicase DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="12">
        <location>
            <begin position="54"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="252"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="482"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM18210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000157201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="81129" checksum="32F9ABBC109C4C2A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLS5</accession>
    <name>A0A0R3WLS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoporin_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000455">
        <property type="protein sequence ID" value="VDM18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLS5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000171301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000171301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000171301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000171301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22558" checksum="5968069847C4EF7D" modified="2016-01-20" version="1">MNSSQEDLFFDQSRSLRLDAFGSSLLEIERGKFQAQHVPTYHHFSSSDLSIEVSISLHDSNNEKQFLYELKPSTYSEKVSLIVSRARSVSFPPPFAALLLSTKLDVPTSNECPISANFLQQLTGHTSHAIIVFGAADGSIFALPTTEPAKIMRIFHFPSLSPVSDLSMLYCIPSPELDIVDGDIDECLVAITSGGLLAACYLNADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMC2</accession>
    <name>A0A0R3WMC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl_transf_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1897</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000591">
        <property type="protein sequence ID" value="VDM18637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000191001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000191001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000191001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000191001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25694" checksum="925F2C1A15BF2B65" modified="2016-01-20" version="1">MALCCVRHVKESTSTRFIYCCILTVVSVLSVIFHTGGLAHSTATRMLGDMMLEFCSHFQTREQCVRFVGYLAVYRFCIPLAIFHFILMLFTIQNSNSQSWRGKIHNGFWFWKCAFIVLLWVISIFFPSLDKATTGKWALLRLIFVLTVTLYLSTFLAYFLLWALWGYLNGCVLNAMIVYVNVCITALLLLLSFAHPRSKLSAAMIFIACCSYSHRITHNRHLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMS5</accession>
    <name>A0A0R3WMS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000716">
        <property type="protein sequence ID" value="VDM18790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000206301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000206301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000206301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000206301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14059" checksum="617BF0FE1EC2E317" modified="2016-01-20" version="1">MRVTSLEVGATGVLARTHVLMGPECVGVSKIVDPGQILNDRLLKLEWPSHNLLAKCVPQSACPLSSLMGAEGVLVHRWTPSNIDPRKRSFCHRNIALITFPEGPITLEGHYVAIWEDLGLEYIPPPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMT8</accession>
    <name>A0A0R3WMT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rod_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000725">
        <property type="protein sequence ID" value="VDM18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMT8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMT8"/>
    <dbReference type="WBParaSite" id="TTAC_0000207601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000207601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000207601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343783at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="1">
        <location>
            <begin position="151"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000207601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="901" mass="100923" checksum="435B5AC0344D2AF1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMZ1</accession>
    <name>A0A0R3WMZ1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2116</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01000765">
        <property type="protein sequence ID" value="VDM18952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMZ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMZ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000212901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000212901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000212901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000212901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29749" checksum="E63067D95AA8686F" modified="2016-01-20" version="1">MTMSFEFLPHGRKHSEVGLYFWRFQQEGINLLDPNTLSTLTLEECRSIFRADNRDVEIPLLEARLQIMHEHATILMNDFDGCFTTCIKVCASSAVKLLHLVCDKFPSFRDRAIYKERHGMLNFALSELLRAQILIADLWLAFKGKSYGHFSDIDALTAFADYRVPQVLAYFGVLHYDDDLMLKLKKRSSGSVWEVEIRGVCLQAVEKTQELLSREGDRQTICNSVTADNFLWLYRRQFAKEVEAAMPMHRTRCIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNZ7</accession>
    <name>A0A0R3WNZ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2472</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001121">
        <property type="protein sequence ID" value="VDM20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000248501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="22883" checksum="7512A83A3C43B805" modified="2016-01-20" version="1">MLLFPHQHTRFRSPRYSLKDSPSQSSYQQHVPSHAVCGGSDSAGDSNPSLQSPTFSTGNSLNPTQGNQNPTSTPIPPFGYPTPSFLCPCASYGWCPTAPNTSIQPIVAAAAAAAAAAAAMTVTASTVCSSSTLNMLESRGTVSTTSGSSQPMHLSSNQYSVNNANNTLSKQIGAFGGFGTTESKTPSGVSVPQLNPTASVSELVNAPFLATARLNLPFLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPV0</accession>
    <name>A0A0R3WPV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2775</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001493">
        <property type="protein sequence ID" value="VDM21125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPV0"/>
    <dbReference type="WBParaSite" id="TTAC_0000279001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000279001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000279001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279036at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000279001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28504" checksum="6378CEEE5EED9EC4" modified="2016-01-20" version="1">MIAICLAQSKQHQVTDRTVEWPHRIRQYLARVMTWIIGVPALKWILPTPTSQPHPYHLPQELTWLDRQLCRLLFPLAQHSHPNIDEAMKYWRKQTKYYGRFLATLQFRHFAASVCFRKLPDGNLMAMSELEVKVHRKVVSLKLKAESSVCGCGFGYSSLTHVISVEMGIPTDFPHCHDCIIYVVDLSRPRTDDLKDILKLLSPHQHLIIAVIVDSRKGRCSRMEYLMQFFDNFGGFNNSPLACTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ45</accession>
    <name>A0A0R3WQ45_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovate family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2871</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001614">
        <property type="protein sequence ID" value="VDM21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ45"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ45"/>
    <dbReference type="WBParaSite" id="TTAC_0000288501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000288501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000288501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000288501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35436" checksum="CA4F25C337C94F81" modified="2016-01-20" version="1">MATRRRLFLDDSAVLTPFLPKFLYSSRTTSSSFVTTTAAATAAFYKLYGDEEITFPRSQQHFISSVKAASSHLLAFQSSSPPPPSQSSSVSATVTSVPSRPRILLTNRGRGLTFERTTPPPLPSTPTTATLTLFKREDFSPHFDDPLLSSVLPPPLHNKATRKQNLFPPPPPTPSDKSTAAVSVVGDDDGVGSIVAMGEEDEGEDEGGNGEEGVHDGFICSLPLSSSSSSSSAAVATINAPTRRSRRRVVKRGNNSTNSTTANVSVPRKVASSSPYFTRSSVVAANHRQRRRRRRRGRGSTYQPQRGVKAVSVTRSHHHQPLRRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQV7</accession>
    <name>A0A0R3WQV7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3132</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001964">
        <property type="protein sequence ID" value="VDM22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQV7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQV7"/>
    <dbReference type="WBParaSite" id="TTAC_0000314701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000314701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000314701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6227903at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="393"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000314701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="775" mass="88521" checksum="D668028320638E68" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR09</accession>
    <name>A0A0R3WR09_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3184</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002036">
        <property type="protein sequence ID" value="VDM22121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR09"/>
    <dbReference type="STRING" id="6205.A0A0R3WR09"/>
    <dbReference type="WBParaSite" id="TTAC_0000319901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000319901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000319901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="70"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000319901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41726" checksum="8ACC7423F90EA14B" modified="2016-01-20" version="1">MSFRCLVHYYEFSSPQNTANYQNTTQPFLRIDGLQERTVYTFRVRAFTSSGPGPWSASSTIRTTADVPDPPSHIKAERINHRQIKVTWSLPRRSTYRINNNFQQRPMPVTGFRIYYAANDNVMESSSKRILEVGAVTMATLDDVSPAESYSIKIQSRGTDKRFGNWSDPVIVSASRDSVYHPRRVTDLRCFGIKSLEVTNPTEASVKVTWLPPPDRRVLKEYEIQISGIKSFINELNDPVRLTLGPRKLIVSSNQQSTFGGRMPNDFLPRDQDSLLVHTIDKLEPNAIFDIEVRPIYETSLDRQRGEAEALWEQTSCRTRMHRKCRYLPLWAFLGSDCTMPILVTPFTDVNISKFWLFLLLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR96</accession>
    <name>A0A0R3WR96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002161">
        <property type="protein sequence ID" value="VDM22286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR96"/>
    <dbReference type="WBParaSite" id="TTAC_0000328601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000328601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000328601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000328601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25901" checksum="1BFDE3E1597BB556" modified="2016-01-20" version="1">MINLATETGHVTLRNYFIDSFPTKLYCERVMNGDPVDIPIRFTIYRQKPSVPKLKSIYPKAYFYNGNDEVNSRYTFFDENWMEMEGLTNLEKPTNTGVEIDVFHHSDWVFSHKEMIPTIDIKAVKVQIEGAREVFLLTTQESEEVITCRVSGTELPDEDDLPVKWSFSQIFYHPAPPLIDGAKIVLNDKVGEGTFCMICTIPLLESSTPTNETCFAVLRKYLLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRX5</accession>
    <name>A0A0R3WRX5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3501</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002539">
        <property type="protein sequence ID" value="VDM22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRX5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000351501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000351501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000351501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000351501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11477" checksum="6CB961B9060149DC" modified="2016-01-20" version="1">MSNQSSNVGSQSFGNQSQKAVVKNADMSEEMQRKAVDCANEAMQNHAVEKDVAAAIKKKFDSEYGPTWHCIVGRNFGSYVTHETKNFIYFYMGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSI4</accession>
    <name>A0A0R3WSI4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3709</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002903">
        <property type="protein sequence ID" value="VDM23196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSI4"/>
    <dbReference type="WBParaSite" id="TTAC_0000372401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000372401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000372401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000372401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9193" checksum="BEB23BC5887BB3E2" modified="2016-01-20" version="1">MSGEWRGIVDASRCDNRSLATLSSGRLLNASMHSHRSYMSIVAEEHHGAAAAAATAAAAAAAADTQLPTVLAQSTPMRANSACLNAIGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSL0</accession>
    <name>A0A0R3WSL0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3735</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002949">
        <property type="protein sequence ID" value="VDM23248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSL0"/>
    <dbReference type="WBParaSite" id="TTAC_0000375001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000375001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000375001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256317at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000375001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56713" checksum="707BCEFC91B9D232" modified="2016-01-20" version="1">MNEKGEKQEVETSEVSAIWDATPDDKATVDGTVHVATDGVGGRCASKKERVIMISAFLTGIEQESYVLRTESPSFLQSGTPTQVSAIHESQTCAPLSAENTSKEEEGKDGNEEVILTRDEIMEKTSDLVDTEITCAYSTCQVTPALSHSSASTRPLTLSVVLELPKDEEEEEENVADEVRMGSLENLASTSFELTTIGAFKLSDGSPIQIMLSGGSVIKHNQTLLEMQRYLLHEKASTFSASDTIKKYLENTGISKFTVQTLSNHEEEERRGSGETVQRSDSQVRAASAMSPIESEVSTRRESRKTCTFRVSEGAPLMLKQLRQSQCKRRKIMWEKHRRYVREEAGSFLEGCRCRPIVLVDDEADCSAIVHMIGKTTESTVGYFSLRQDAPPPVTTICHSCFKRRQIVWSKYRRQLSEEAETFLTEKLTHRDDKQSMSLVSLPHLLPSLNAPASVESIDIGPARILITSNRREDGGVVAHIVTEFPLNPVPSDNSKNLQFVFDVAMPEEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSL1</accession>
    <name>A0A0R3WSL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3737</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002952">
        <property type="protein sequence ID" value="VDM23253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000375101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000375101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000375101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276199at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000375101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24933" checksum="5C6B0615BC0F3CB8" modified="2016-01-20" version="1">MSKVGEKKVFAHSFDAGGRQSGGCRRGLSVALPEPPLRLKENPDVIWTPAYYGDEEDFKEGENDGENWVILFTKENSQLILKKGEKRYPISGQYEVKIGDEIIKANLLYMLIRRVRKITGSGGDETAQRKGASLVFYKDLKYFAGSSKLETFTRKNNDELIAKGEFGEVWLANHYKEVSCHSALSYDILINICGSSTNLTKSVLMSTHFMLKWAQNCACDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT96</accession>
    <name>A0A0R3WT96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-directed RNA polymerase I subunit rpa49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3971</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003390">
        <property type="protein sequence ID" value="VDM23891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT96"/>
    <dbReference type="STRING" id="6205.A0A0R3WT96"/>
    <dbReference type="WBParaSite" id="TTAC_0000398601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000398601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000398601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000398601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42340" checksum="6CE958939E66DAF4" modified="2016-01-20" version="1">MVVYVHVLELSLLRYVTVIYNKKMRKMEISYNLPEFLSPKFDVEVVNDAATRSSTLDPHALTQTFGSVWSKKYLRDLDQSLAHTSAVSDATVLQKVACGQTALANDKEKLGQSEMKSGINGDKVTQHELVLPPFDQKTLSVAQIFPIQKIVPPALASCLAKEAKALSDADESVRNQWLTEGTYPRLIVDRLPFLPIDNPDSVDQSGSGTKRKRKSRNSTDRPVTRLGMATHLALLGHMIKMFQLKPRELQRRTPLPDTPHPLANHLLNEFTVFASRSGNERSKSRLMTPILRDKLICHILVLLLHCDNFATVIDALPSDFKMSSVRLKNHFAFIGCSFSKQEVETSSTDQKKEGAKQYHTVARLSAPLVLKAAHAFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTZ7</accession>
    <name>A0A0R3WTZ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4222</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003948">
        <property type="protein sequence ID" value="VDM24461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTZ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000423701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000423701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000423701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000423701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55419" checksum="5141D913BAEBAEED" modified="2016-01-20" version="1">MRFVGKSRTTLPEDPNWPYFDSPWDLLRDCQDYNSDISNTSSHLGACILSHMLGFLSAYIFPFVGLFGVVSNILVTYIFLFVFRKPSRQMIYLGCVAAADVITIILFGWIWVFPAKGLPYATGARVYFFILNVNIYSCKIMRYLYSFSSCLSSSLFLLTAFDRCLCVYFPLKFARISRRRAWEAVGVITLFSALAMLPFGLLVEHTLSNGKIICWVKVGPNALQIYHVLLANSSLLQTILVIIINIALLIRLRQSAVLRETMSKCTSANREIAASMLLVILSTIVVICTLPQSIAYVFSTILAEVLDGDTGRTAVRIAYNISDLGWQLLFFQQASNWALYMKRMKNFRRATLRLLRCHCNRGRGLVDDAFGSIHYLSTKARYLTSELRITRGDVSKVYGMRFATAKKGGVSDFWKMKYSGAVLHTSFGNFQCQGKGGNDSNNNNISEICRYTYRGSMRHTTTMSTITPGTVYADIDTPTEPALESGRVLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU79</accession>
    <name>A0A0R3WU79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDC48_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004116">
        <property type="protein sequence ID" value="VDM24645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU79"/>
    <dbReference type="STRING" id="6205.A0A0R3WU79"/>
    <dbReference type="WBParaSite" id="TTAC_0000431901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000431901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000431901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4150at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057896">
        <property type="entry name" value="MTRES1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25818">
        <property type="entry name" value="MTRES1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial transcription rescue factor 1 C-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000431901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17060" checksum="2B58EDEBB8141CFA" modified="2016-01-20" version="1">MPRLWLQTVFRTFVPSRLLIRVKNAPYSGYLHMESSYGLIGRVITTQMQTIRFDKVVRKGLNMTQSDFEKAFYDRRFRLNKEQPFKKSCNVNEGDMLDLIVREEDGKIYGKRVVLEKIAKNGASFCVVLRCVRQIHQLYADCYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUU9</accession>
    <name>A0A0R3WUU9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4524</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004665">
        <property type="protein sequence ID" value="VDM25113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUU9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUU9"/>
    <dbReference type="WBParaSite" id="TTAC_0000453901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000453901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000453901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="4">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000453901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45914" checksum="A5CECF358D36E7C0" modified="2016-01-20" version="1">MVHKRRPSKGSQTISQPQTQILPMDCDENVLQSVTHNIDAIHQDLSLLDLESFLLPSTHLPVLDVDAAQLKNVQQSHLLPLFNNVRTASRSSKLYLPRSIAPQSTIPSVQHYVLIPNAALNRSNHLAPCSSVLNIPERSDGRYTIAMEAKREATVIKKVNKLIKRGLWSSNRLPKVMEPPQPLCHWDHLLEEACWLAEDFKQERLWKKAIAKKLADAAMMFCMISSELARRNEEELEGLRQRGAAMVAKMVQDWWAEVSETASSLSALSEHRQWCAALQRNRVFLTHLTDTGANWMFEAVSRSSRSMAPPPFSASKQTLPLAPTMVLEEEDVDELWLPPKSSTSSTANGSVESLTDAGVQFNPDAFSWGLQSHMITAAPMSLDSSPSEGDSEDHVSTSSDSSGASTLATDQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV54</accession>
    <name>A0A0R3WV54_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004922">
        <property type="protein sequence ID" value="VDM25316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV54"/>
    <dbReference type="WBParaSite" id="TTAC_0000464401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000464401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000464401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000464401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11795" checksum="472BAA4D8A04CE03" modified="2016-01-20" version="1">MTSERVLVLKINHPTNLNERPVTVAKEPFPPASVNIAQHIGNQKPRLREGPRTIRPNSFIHADIQHSAMPDEAVAQEWRLHTAVVLQLQENVPQHHLDIHSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVJ0</accession>
    <name>A0A0R3WVJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THOC2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4765</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005269">
        <property type="protein sequence ID" value="VDM25600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVJ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WVJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000478001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000478001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000478001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000478001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21807" checksum="4E03BD649C48CBF1" modified="2016-01-20" version="1">ISSSEASGTTKKKAKSRHQQEQLQQAGVQNGVKKSGNNSTLSTKKSKSSASDSSLLTEELNTLIRWVQSALVGIELREKLDIPTLVELLTTIDAPYEVESMLVAYLGSSPRSEQFVREFLDRRHTCWQLHRKRVEEMQSDSKLKKGHNDQQPSSAPANNEGTVYSVNTYSEANDTHPESVVCYPDFEGLALVILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVJ1</accession>
    <name>A0A0R3WVJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005273">
        <property type="protein sequence ID" value="VDM25603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVJ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000478101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000478101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000478101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000478101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="311" mass="32527" checksum="C0C625E1779B7DED" modified="2016-01-20" version="1">MSSVSSPNKSSRRTYSTLSCVSKRPDSSVFDSGNVEPLKVIKRPTVGVACGSQPLFNHRGSGATLDDASSLVDQSSSAVSPAKLTSSKSSLTGTSASQSDLVGINCKLTTLTINQRESIYVRTLFRYDPATDRGLAARGLAFEHGDILYVVNASDQEWWQACYAFPISPPVWASAYASATVVSTNCNTPPEVPASHTKSIPTQQPSTPSCRPAIIPSQRRVERRSRLSAKRVKFVDKEVDIGGGSPSPWSLGGGDTPNLPYALESHRFFGSTGGGGVEGSSASLSAVAGGGGSSFPTGDSVSVGMFVLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW10</accession>
    <name>A0A0R3WW10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4936</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005713">
        <property type="protein sequence ID" value="VDM25911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW10"/>
    <dbReference type="STRING" id="6205.A0A0R3WW10"/>
    <dbReference type="WBParaSite" id="TTAC_0000495001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000495001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000495001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000495001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="25591" checksum="CCB5C9DDF04B21A3" modified="2016-01-20" version="1">MNVRLRQTGLESNLPLQLHVRVNAVTASESSGETEGTEVVSQPVSEPEPEKLEAKEEEPSGCRPESSSPPTTIVLDDVVKPPASGIESGSLGSSVAVCYSGGGGGSGRRPSSGPERLGPTASLHCESPIQVERICSIPSEPLPQFASSSVTQGPRVVPLPSREIAKEAAQRILKDAAERHRRRVCAMQARLERTSAGGMASAGASLLPHQTQWVKWLAVAVAMVLIALLVRRLMIMSTTGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWI1</accession>
    <name>A0A0R3WWI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Laminin EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5104</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006274">
        <property type="protein sequence ID" value="VDM26278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWI1"/>
    <dbReference type="STRING" id="6205.A0A0R3WWI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000512101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000512101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000512101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000512101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13042" checksum="D46F591D96E5E5C2" modified="2016-01-20" version="1">GSWGVECKQKCECPTGKCNSVTGTCQCPPGRYGKKCEKIGCPPGYWGADCDKRCPKQCSTGYCHSKTGACTCAPGKYGASCHITCPEGTFGEMCAEACPAMCSDQNSNYKGCDPEVSMTNCDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWI9</accession>
    <name>A0A0R3WWI9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5114</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01006294">
        <property type="protein sequence ID" value="VDM26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWI9"/>
    <dbReference type="STRING" id="6205.A0A0R3WWI9"/>
    <dbReference type="WBParaSite" id="TTAC_0000512901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000512901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000512901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271280at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000512901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29807" checksum="576C4BB0226BDAFB" modified="2016-01-20" version="1">MDVVDGVISSFSYGFYTPHEIRSLSVLEITSDAIFDSITNRGVDGGLHDMVLGPCSEKDVCAHCGLGFLHCPGHIGHIEFSKPVYNPLLFDLVVRVSIYVSITNGLDLLLPSKPKPSEISDLKSLTPSELRRVAIRSMSTRRRIPCRNCTSKAWVLKHVNHQQIVMRPVSDIRNSRHVAVSKYNIGDNDPNYEPGELESWAQIEAQLLGDKYTSRPVVSFESEGVVNDGIEFSDLAESVRERLMELSSSSQKEAFSSPGNSDNHSSPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWS8</accession>
    <name>A0A0R3WWS8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5203</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006576">
        <property type="protein sequence ID" value="VDM26461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWS8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWS8"/>
    <dbReference type="WBParaSite" id="TTAC_0000521801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000521801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000521801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000521801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21135" checksum="D23A586DB9207736" modified="2016-01-20" version="1">MTETGVEAEFALEEPSLSYHRLGNDLLGSCAENEITIVAAHWKFIVLGHKDGTVNIFDHLGNLVQNGFYKKHFCPINQISISDDDNFVATCADDGFVFIYSLSEPEHGELLNLNRPIKALAISPNYSKTRKLITGGKSVRVGFGLIDLVWSVADTLDPLTNSSIPVLFNELLSNITQFEGERESDNEPFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX03</accession>
    <name>A0A0R3WX03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5278</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006837">
        <property type="protein sequence ID" value="VDM26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX03"/>
    <dbReference type="STRING" id="6205.A0A0R3WX03"/>
    <dbReference type="WBParaSite" id="TTAC_0000529301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000529301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000529301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240031at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000529301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18243" checksum="D30D2130C8A3971B" modified="2016-01-20" version="1">MAHFLLTTLTDITAGALFAATFLRRISKKTRSPSDSMDQRRFASEFEQLAVSILDACYFNNKENTMQLLVMERRSFAMLSCLMIASEGNCREFMQHRACQEYLDRVWAYKLLIKRLSGRFILSLVVGAVFPPAVPFVAEYDESMYGKSAKSREAVRLSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX87</accession>
    <name>A0A0R3WX87_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5363</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007190">
        <property type="protein sequence ID" value="VDM26803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX87"/>
    <dbReference type="STRING" id="6205.A0A0R3WX87"/>
    <dbReference type="WBParaSite" id="TTAC_0000537701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000537701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000537701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000537701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21859" checksum="EE63EB9AC734804C" modified="2016-01-20" version="1">MECLIGIAFNDFAIVAADARVNHSVVTLKDDADKMFKLSKHCLMSICGESGDTVQFAEFIQQNMQLYEIRNGYELTPYAAASFTRRNLAEALRTRNPYNVNLLLAGYDSCAGPKIYYMDYLASMVDVPYAVHGHGSFVTLAVLDSQYDPAMKIDHALILLKSCITELQKRFVINYGRFIVKVVNKDGIENLPDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY04</accession>
    <name>A0A0R3WY04_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5630</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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    </dbReference>
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        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000564401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19874" checksum="E91467B09FBE2518" modified="2016-01-20" version="1">MGHRQAVRDVTFNTAGTQFLSASYDRFIKLWDTESGKCTGQFNLKKVAYCVKFNPDEDKQHLFLAGCADKKILCYDVRSGEVVQQYDRHLGAVNTVTFVDNNRRFVSTSDDKSLRVWEWDIPVDFKYLADPSLHSMPAVTLSPNGKLPFCVCESECRLRNWQYNRSAPDLMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY55</accession>
    <name>A0A0R3WY55_HYDTA</name>
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        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TTAC_LOCUS5680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM27431.1"/>
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        <property type="protein sequence ID" value="TTAC_0000569501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000569501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000569501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5003" checksum="97FC7158E0B96E19" modified="2016-01-20" version="1">MEKCKKEQEKKYGGGSGGGGGGEEGGEEQKKSSGKGKQKKQEEQDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZM2</accession>
    <name>A0A0R3WZM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6242</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000625701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000625701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000625701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258881at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="335"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000625701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="745" mass="82240" checksum="BF451C32CA7EDE98" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZY7</accession>
    <name>A0A0R3WZY7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FCP1 homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6382</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZY7"/>
    <dbReference type="STRING" id="6205.A0A0R3WZY7"/>
    <dbReference type="WBParaSite" id="TTAC_0000639701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000639701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000639701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="6">
        <location>
            <begin position="201"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000639701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52004" checksum="EBB5FE4D5ADC34BF" modified="2016-01-20" version="1">IVSITRSCRKPQHPSITPPRSCRKFRYHCRKVSRISQPKNPRASKSHFQPESSSTPLITHVTPTSAVHSWQPPVRCDDVQSEDKKVSDSSQAEESVWLSDPSADSSTASSSISSLLPTSSSGCETKGDAEVEDDSLEIMEITQAEVGNMGGTQSSTIPSAEEYEADAGELCEVDPFAFIRTLPPVSDELFAHPPALPKRTRSCPEHCLVLDLDETLVHCSLEPLVDAQFVFQVVFQGVVYMVYVRVRPHLFHFLERVSELYEVVLFTASTKVYADRLVNLLDPKKQWIRHRLFRENCIFVNGNYVKDLRVLGRDLTKTVIIDNSPQAFGYQLSNGIPIESWFTDQEDNELMKLIPFLERLAKLSDVRPIVDSQFRLQSKVFAKELPQPPFQCFTSTAATTYSCDENIEVAEPEGECGDDDEEVIDLAEADDEVELGVQGTGQSDECRREAWRRGIEQVEEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X038</accession>
    <name>A0A0R3X038_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6447</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X038"/>
    <dbReference type="WBParaSite" id="TTAC_0000646201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000646201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000646201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248528at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000646201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1126" mass="126209" checksum="31A75C30D082CDFF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X072</accession>
    <name>A0A0R3X072_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6484</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X072"/>
    <dbReference type="STRING" id="6205.A0A0R3X072"/>
    <dbReference type="WBParaSite" id="TTAC_0000649901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000649901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000649901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133082" evidence="10">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="11">
        <location>
            <begin position="476"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000649901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="73497" checksum="EE312DF3C5D6482C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0A5</accession>
    <name>A0A0R3X0A5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiq_cyt_C_chap domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0A5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0A5"/>
    <dbReference type="WBParaSite" id="TTAC_0000654501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000654501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000654501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="83"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000654501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29590" checksum="CFDB0C8E35C88422" modified="2016-01-20" version="1">MKSALVKSHRLRHFRPDGFYLPRRAIPTSTLQSSSRDKKTLLGAMKHLMGHHLRYPTWRLKLSGANMFAVCAEYPDVNEFIENLNLPDTFQTWFSLTTLHIWMCLIRLRREGQEGQILKKPFIQFIWTDLKNRMRPFGILRNQHDHIEVFNMQFFGSVFAYDEAFLMHLDTALAAAVWRNLFFASPHTSAQDLDSVVHYIRKQLSHLDALSSDQIVGKGMPTFLRLFEDKLDLEYANRRLNYCLTWPEWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X160</accession>
    <name>A0A0R3X160_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AAA_6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS6896</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X160"/>
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        <property type="protein sequence ID" value="TTAC_0000691101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:axoneme"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:dynein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
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    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
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    </dbReference>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
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    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C"/>
    </dbReference>
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        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
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    </dbReference>
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        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="AAA_6"/>
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    </dbReference>
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        <property type="entry name" value="AAA_8"/>
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    </dbReference>
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        <property type="entry name" value="AAA_9"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_AAA_lid"/>
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    </dbReference>
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        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MT"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="805"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1421"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1769"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2074"/>
            <end position="2104"/>
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    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2235"/>
            <end position="2283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM31178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3449" mass="392302" checksum="047BBEE72004ACEF" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1R7</accession>
    <name>A0A0R3X1R7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X1R7"/>
    <dbReference type="WBParaSite" id="TTAC_0000717501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000717501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000717501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mot1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000717501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10890" checksum="3619313CA8FBBDC3" modified="2016-01-20" version="1">MALDKRQLFNANPSIDALXXXXRAHRIGQRRVVSVFRLLTAGGIEERIMSLQTFKRHIARTLISQPDNQALGEMDTSQLIDNMAAAAAEGASVLRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1R8</accession>
    <name>A0A0R3X1R8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7161</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1R8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1R8"/>
    <dbReference type="WBParaSite" id="TTAC_0000717601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000717601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000717601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000717601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43355" checksum="F91E502DB535E395" modified="2016-01-20" version="1">MRRMISFRSKLHFFVCIFTRKKRVEKLTLGEDDSSDGEVYATNEVPPLGDDVEDEYNEEWEKFYKPNADADDAYSNELLQNIDEARSVVVEEMSEYCGSLPDLDDFKAVDDFEELPDELKSHIRLLKDVLSHYRSGPLPKTIKMLPHLPGYDSLLEMLSPLEWTSHVYPRIVKVFASKGGEQAFHFYENYLLPKVRDDIAKNGRLCVHLFEALIASLFRVREFLAAVFYPWIKSDMTKTEGIILAHLIKKASIRAHFSAVALSLTCEEDFSIPRSMVIEAIINKRYFLPEDAVARLVAYFASFDKANCSMYFTSEGRMPLTWFKSLLAFLEFYREGIRPDEREQLVRLCRRHEHPSITPEIRALIGLIPTTRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1S1</accession>
    <name>A0A0R3X1S1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020350">
        <property type="protein sequence ID" value="VDM31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1S1"/>
    <dbReference type="WBParaSite" id="TTAC_0000718101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000718101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000718101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000718101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="8903" checksum="BAC79E6690D7ED6E" modified="2016-01-20" version="1">MPSKVEFSSIPRSCYSNDGSVVAYNGSSFLGGLVLLNLEMPAAANNPGALTHGSGLPRPHGRRVGPAAPGHPVPNEGQPLKGELNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X214</accession>
    <name>A0A0R3X214_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X214"/>
    <dbReference type="WBParaSite" id="TTAC_0000729401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000729401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000729401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000729401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15721" checksum="B7A2C6D83C9299B4" modified="2016-01-20" version="1">MGSEVVHFKGSGRKCVHSIIPSREEVTTICDFLKSEVKEREGGRGRRERGKWEGEEEEREEEEEEEVEEESEEANEEGEEEEKRGGAEGEERDEVEEEGKEEEEEEEALDLSTPRDNSHNAEINCLEILNFELFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X218</accession>
    <name>A0A0R3X218_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7284</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020359">
        <property type="protein sequence ID" value="VDM31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X218"/>
    <dbReference type="WBParaSite" id="TTAC_0000729901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000729901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000729901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000729901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8221" checksum="2D718EC04AA244E7" modified="2016-01-20" version="1">MMNHFWRLGVHLPTIVISQSAASDRIISRGRHVVSGIETRPLINGSLTLIRHLDINRRLNARKKAEMEDPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2E3</accession>
    <name>A0A0R3X2E3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Delta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7439</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2E3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2E3"/>
    <dbReference type="WBParaSite" id="TTAC_0000745401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000745401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000745401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249379at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="301"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000745401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57557" checksum="C7868A459119614E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2L9</accession>
    <name>A0A0R3X2L9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein regulator of cytokinesis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020380">
        <property type="protein sequence ID" value="VDM31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2L9"/>
    <dbReference type="WBParaSite" id="TTAC_0000754201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000754201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000754201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255147at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000754201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="552" mass="62578" checksum="D8664B2CFE694E47" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Q1</accession>
    <name>A0A0R3X2Q1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020384">
        <property type="protein sequence ID" value="VDM31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Q1"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Q1"/>
    <dbReference type="WBParaSite" id="TTAC_0000758501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000758501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000758501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000758501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36812" checksum="972E324BFAC7E0D2" modified="2016-06-08" version="2">MRTSTVLIPLIAFTFGVLFRYWPRSCLCHINQRLDGRVALVTDGPSFMGPEIAAELARRGATVLLGCQSKQHFDSVRDKVLRLYGVDGERVNMDFADEVVKKNLTPVQEPQLKYMPLHLNSLKSIKDFAKEIMNVTSRLDFLINNAVVSHGPYFTTMDNYESTMAIGHLAHYLLTDELRPLLLKTKPGARIIIISSAEHTSGSFKEHGFFINYNGFNSVKALAQVKLANVIHGVILAQKFKGTSVIPVSVHPGYVLPDFGVFIPAIFGAFFKTYWEAGQSVLYLALTPKLQPGGYYSNCQLVEPAKEAKDEEIIKFVRSESDRLINLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3R5</accession>
    <name>A0A0R3X3R5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myelin transcription factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7987</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020428">
        <property type="protein sequence ID" value="VDM32468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3R5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3R5"/>
    <dbReference type="WBParaSite" id="TTAC_0000800201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000800201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000800201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280315at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000800201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25966" checksum="01EE5CF49D008BD5" modified="2016-01-20" version="1">MVRSAIESIKQELRDCRGHHRSHGGTQGERKHKRTVSESMGSSDTPVTKRTCIRKSDGHLALAEELDLEGHSTSPSLSTTTTTTTTDEEDVDYGDKKEEEKVANVGMEKFPPSPIGEEDNPGGVAIISDSDEEGLDSTLAEDDEDDDDDVDIDDEEVEEEKGAVEQESMEGTDKHSEQFKSSVPVTVETDLQEEMRQYLPPPCPLEYAENPLLHMSPQLYAFSASVKARDGFFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X434</accession>
    <name>A0A0R3X434_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine and glutamate rich 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8134</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020453">
        <property type="protein sequence ID" value="VDM32637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X434"/>
    <dbReference type="STRING" id="6205.A0A0R3X434"/>
    <dbReference type="WBParaSite" id="TTAC_0000814901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000814901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000814901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000814901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="24156" checksum="5C85D5282F9F47E9" modified="2016-01-20" version="1">MARSRSRSSVDRRRSRHRRYRSPSRDRRKRDRDHDRSYRAGDRPPRNSNRSEHRRKRDSSSSQSNDEEKRLKKSHLRDIDRKIREARKKEEYEKRMLEMKERERREQEERERELEAARQLEARVTEAFEAALVDRAADLKTELERLYQAELEKRVQQRMEDIEREIQRAHEEKRRVERLSVINLDFVFITGLVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X444</accession>
    <name>A0A0R3X444_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8145</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020454">
        <property type="protein sequence ID" value="VDM32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X444"/>
    <dbReference type="STRING" id="6205.A0A0R3X444"/>
    <dbReference type="WBParaSite" id="TTAC_0000816001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000816001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000816001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000816001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26584" checksum="90848A1B41695003" modified="2016-01-20" version="1">MDAKVFPSHTGPLTDARSHTISPTCSGTSVVGIKFKDGVIVAADSLVSYGSLGRYTNFDRVLKVNEQTVLACSGDVADFQYLTKLISQQVLIESLLGDGFSTSPQALHSWLTRVLYHRRSQFDPLWNSYIVGGVQKDGTPYLGYANMIGVAFTENCVATGFGSHLAVPILRKVIETKADSNVANLAYEDALAALKEAMTVLFYRDCRAFNMYKIAVVTKDGATVSENQKLEANWEMAGSITGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B6</accession>
    <name>A0A0R3X4B6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Apobec1 complementation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8229</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020468">
        <property type="protein sequence ID" value="VDM32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4B6"/>
    <dbReference type="STRING" id="6205.A0A0R3X4B6"/>
    <dbReference type="WBParaSite" id="TTAC_0000824401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000824401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000824401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000022">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000026">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="278"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000824401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="890" mass="95980" checksum="613251C6659441E4" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I2</accession>
    <name>A0A0R3X4I2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase_AAA_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8307</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020482">
        <property type="protein sequence ID" value="VDM32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I2"/>
    <dbReference type="STRING" id="6205.A0A0R3X4I2"/>
    <dbReference type="WBParaSite" id="TTAC_0000832201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000832201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000832201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059067">
        <property type="entry name" value="Znf_ribbon_CLPX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26040">
        <property type="entry name" value="Zn_ribbon_CLPX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent clpX-like chaperone zinc ribbon" evidence="3">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="264"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000832201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="45301" checksum="FED7AC3D34F1AA2C" modified="2016-01-20" version="1">MALEANVSSKNANSGGTEGPSSGPSTTDGGSFSPSAASGTGGESGTEGGSGDGPIITCSKCGAPLHPIEPSTSHISRFMKCDSCQQLYTFIDKTALKSFVRVDGHAPNPPPSPKQIHSYLDRYVVGQDHAKKVLSVQVYSHYNRIHHNRLNCEGDLTGLASVEQQGAYSPSKPATNDAVVRPISPAFTSFPFQSGKIIGRRIDASGPSVTELFHLLSDAGNRSGSTNSIRSVDASNPTYQAPGIIAGSRRIYETHKGEPVRLEKSNIILLGPTGSGKFFPLDIPPRQAAVLNARAGYVGEDIESVIAKLLQNANFNVERAQQGIVFLDEVDKISSRAGLLHSIRDVGGEGVQQGMLKMLEGSLVSVPDGKGARKIRGESVLVDTTNILFIASGAFTGLDKLVARRKSKQVNHVSLFLFHADELTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I7</accession>
    <name>A0A0R3X4I7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Large neutral amino acids transporter small subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8312</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020482">
        <property type="protein sequence ID" value="VDM32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I7"/>
    <dbReference type="STRING" id="6205.A0A0R3X4I7"/>
    <dbReference type="WBParaSite" id="TTAC_0000832701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000832701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000832701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3257095at2759"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="VDM32840.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000832701-mRNA-1"/>
        </source>
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    <sequence length="209" mass="23347" checksum="1EAAA6A573FE4507" modified="2016-01-20" version="1">MRNYLNFLVEEMENPGRNLPLAIAIGLALVTGLYMLTNIAYLAVLSPYEMLSTGSGSSAIAVLVLAVGYQFYSNLFALIELAGFAFSFIAALAVTSLLYMRYREPNLKTSFQLPIFFPILFLGCDLFILVLTIYQQPRESLSNVVLMLAAVPIYWLGVSWKKKPRGFQNFIWKGTIFLQKVFACVPVEDESQLDGPVSSGKVEKQVETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X509</accession>
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        <submittedName>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <dbReference type="NCBI Taxonomy" id="6205"/>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="1313"/>
        </location>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000852801-mRNA-1"/>
        </source>
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    <sequence length="1494" mass="160821" checksum="5E381328D10110EF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X512</accession>
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        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">TTAC_LOCUS8516</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03371">
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000853101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="35526" checksum="1DA531975D87CAC5" modified="2016-01-20" version="1">MANRTVKDAHTLHGTNPQYLIEKIIRSRIYECQFWKEHCFALTSELLVDKAVELKYIGGTYGGLTKPTPFICLVLKMLQIQPDKDIVIEFIKQEDYKYARALGAFYLRLVGESVEIYKYLEALYNDFRKLKQQDTTGKFSIIRMDEFIDQLLNEERVCDVILPRLQKRSVLEDNNALEPRQSILDEDLEEININEELEASQEVDQHEEKERRDQKREKHRDQEDDEDSRRHRKHRHRDRDHEYDRRRERDERDKWDRRRRSRSRSRDRRRGDREDSTDRKRSGKDRDRVHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5H3</accession>
    <name>A0A0R3X5H3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransf_25 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8701</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM33331.1"/>
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        <property type="gene ID" value="TTAC_0000871601"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tRNA methylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000871601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29896" checksum="44C2799AF0F5C940" modified="2016-01-20" version="1">MILDEDLLTFLNISILPQVYDTIAGSFSDSRYAPWPGVMRFLKSLPPGSWGADIGCGNGKYLVAVAQNNLLLSPLLASDTSIRLLDHVRGRGFDAVAANLLALPYRSGLLDFFICVAVLHHLATPQRRLDGIKSMASLLKGGGLGLIQVWAKDQHWKGKSTMYLKSGKFESTEGVVMEEVAVPGGGKIPLQKLRTPFVATDVLLPWNAVNKKVETPNKVALMRYYHVFETGELENLIAQVSCLELVESVYEQGNWSAIVRKIEPTLGENNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5W9</accession>
    <name>A0A0R3X5W9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLCXc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020613">
        <property type="protein sequence ID" value="VDM33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5W9"/>
    <dbReference type="STRING" id="6205.A0A0R3X5W9"/>
    <dbReference type="WBParaSite" id="TTAC_0000888501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000888501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000888501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF103">
        <property type="entry name" value="RE10370P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26178">
        <property type="entry name" value="PI-PLC_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000888501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35658" checksum="65E46B82256FD641" modified="2016-01-20" version="1">MAYLPEETTKVPLSRIAIPGTHNSGSYSIEESSPISPDMSFGFLTRVLGLFFDIPFSKWSVTQNTNFTTQLQSGIRYFDMRVAMDKHTCVNSHPNFSSDIYTCFFLVHGQYANRVSEELKTIKSFLEHHPKEVVIIDFQHFHGLNESLKSVFTDLVKEVFGEKLEPYGSQIPSLADMWSRKTQVIVLGYEKKLDKSQEGTSVLWPRSAVRQPWPNTRNPEFLRTFLTKLLKGWMRKNRPGYFQVFQGILSPNLDYLLLNPKGGIENLARIANTVVEKWLDGLDRLHGIVITDFSVLGFPTFSRKVFFMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6H3</accession>
    <name>A0A0R3X6H3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9090</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020676">
        <property type="protein sequence ID" value="VDM33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6H3"/>
    <dbReference type="STRING" id="6205.A0A0R3X6H3"/>
    <dbReference type="WBParaSite" id="TTAC_0000910501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000910501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000910501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000910501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46516" checksum="FFA57CD07C71EBC0" modified="2016-01-20" version="1">MSVDKDGDRVIVCDNGTGCIFPSVLGRPILRASVKVGNVEVKDLMIGDEASELRSMLELSYPMENGIVKNWDDMTHLYDYTFGPSKLNIDTKHAKILLTEPPYNPKQNRSKMLELMFERYGFNAVYVAIQATLTLYAQGLMTGVVVDSGDGVTHICPVFSGHTLTHITRRLDVAGRDITRYLIKLLLLRGYAFNQTADFETIRQMKEKLCYVAYDVNQEQNLALETTVLVKKYTPMRTINTPLVTFSLVCVDCPSCFLVVLFTCIVQLPDGRVIKVGGEQFGAPEALFQPNLIDKESVGISEMLFNTIQAAPIDTRSDFYKYIVLSGGSTMYPGLPSRLERELKQLCVQNVLKGDATGLSKLKIRIEDPPQRKHMVFLGGSILARLMQGGSANYWITRAEWKEQGVRVLDRMESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7F0</accession>
    <name>A0A0R3X7F0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020829">
        <property type="protein sequence ID" value="VDM34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7F0"/>
    <dbReference type="WBParaSite" id="TTAC_0000947501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000947501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000947501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000947501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17045" checksum="B9BDA6F01F3B8585" modified="2016-01-20" version="1">MLDFRTDEEDEFVVPHMEISCLRNSFAYLTALGDPFGCIYNFDDLDLKTQVSAAEELDAEAQQVQDRLIRNYHYWWPNPPQLPMSQTQTPIPPSQQQQQQQQEQQQEQEQEKEQQQQQQQQQQQQQQQQPEPKSDRPPTSQNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7W3</accession>
    <name>A0A0R3X7W3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Par3_HAL_N_term domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020933">
        <property type="protein sequence ID" value="VDM34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7W3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7W3"/>
    <dbReference type="WBParaSite" id="TTAC_0000963801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000963801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000963801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000963801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10862" checksum="0562F6D726C2445B" modified="2016-01-20" version="1">MELRSMECDEPIEVTPDVQATEDDNSTELQPTVHVEICLTRGSTASRAIVCRAVETYLRAKQGACNLPAHWEHILVGTSPSEQIFFNENIASVGSTDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X877</accession>
    <name>A0A0R3X877_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9737</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021013">
        <property type="protein sequence ID" value="VDM34648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X877"/>
    <dbReference type="STRING" id="6205.A0A0R3X877"/>
    <dbReference type="WBParaSite" id="TTAC_0000975201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000975201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000975201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000975201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51156" checksum="5C97B53D088CA598" modified="2016-01-20" version="1">MSKFASPSPRGAPLPSSTPAIKRFSEPISPRRGYGNDGSRCSDRCSGNLHEISPIVGTSSSFDTTRQSNGPDRSFASPNVDDSDHKELTTADLLDKLSKDSSAFAGHLRNSLLYGDHLRTANFMGLAPSLGSPTDTMSLHSALLERICKSLVRCIKSDVSMTLEYKEACPEVIGVQSKNSVVERVPENARVDAQSILHPIFDSDREAMNDAGALALLQHDNIVRYFDAWSESETIVMALEFCHGGSLFDYLYPNRPFPSGMAVHDSLIDRSSEDLQLAIRPLSEPGLKHLLTQMSSALAYLHTNFKLVHGDVKPSNILLQLPDDEASKAYFSEELAIDASTRCVDILQSDTPSGIIFKLSDFGRSTLAEHDTMLEALGDGRYLPSFDDESDPIRVALGRDVYALGAGGDMTFKTLDRFRSGGFDPEDALVLPSSLRAIVTSMLQPYAADRPTSSEVFASISCGGSELRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8B2</accession>
    <name>A0A0R3X8B2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9772</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021042">
        <property type="protein sequence ID" value="VDM34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8B2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8B2"/>
    <dbReference type="WBParaSite" id="TTAC_0000978701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000978701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000978701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000978701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="61960" checksum="B73E7B795668268E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8S7</accession>
    <name>A0A0R3X8S7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9937</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021173">
        <property type="protein sequence ID" value="VDM34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8S7"/>
    <dbReference type="STRING" id="6205.A0A0R3X8S7"/>
    <dbReference type="WBParaSite" id="TTAC_0000995201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000995201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000995201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21200">
        <property type="entry name" value="CH_SMTN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF88">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000995201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17334" checksum="7EEC715E4D5ADF22" modified="2016-01-20" version="1">MLSRFLLCYSFAASKRPGAASAKEIMLHWCQVMTKGYPHVEVKNFGSSWADGMAFCALIHHFYPDAFDFSILKPENRRANFELAFKTAEELGNVAPLLDVEDLLRTKVPDWKCIFTQIQLYYRRFQLEQGTKANKPPVGLHPSAPPPAPEGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8U0</accession>
    <name>A0A0R3X8U0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger CCCH domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9950</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021186">
        <property type="protein sequence ID" value="VDM34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8U0"/>
    <dbReference type="STRING" id="6205.A0A0R3X8U0"/>
    <dbReference type="WBParaSite" id="TTAC_0000996501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000996501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000996501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="965"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000996501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="107767" checksum="78B56E7FCD836100" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X905</accession>
    <name>A0A0R3X905_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10015</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021241">
        <property type="protein sequence ID" value="VDM34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X905"/>
    <dbReference type="WBParaSite" id="TTAC_0001003001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001003001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001003001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6245295at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001003001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57827" checksum="303765D95CFCBF74" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X914</accession>
    <name>A0A0R3X914_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4485 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021248">
        <property type="protein sequence ID" value="VDM35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X914"/>
    <dbReference type="WBParaSite" id="TTAC_0001003901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001003901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001003901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6226546at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001003901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38332" checksum="6130E72EC0D50E4A" modified="2016-01-20" version="1">MMEITKRAMCLDICKCLDGPNVVDICEAVPTAKCILKSKTIRDVLYKYVSKMQWVNATVYRWLYTALSMPEEEMESEEKIELQSTQLYKAIRYYQEDCRSRSYCKNAVWPGGDKIFHFLVIESQLKDLDIRTYFLNTIVAWGLVHGKHPKKTTSKYGNFPQIVKRVSNFDIHFDVSTLQNEVSQYRASLDISSIRQFDAVVYAINSTQQCQNCQSLPDELRTLMANISSIASKKSFHYPLLLILDFDAPQKGQSTFNYGRSNILVSNLLQLNEAAFKCSSQDSVSVEQYKWWRVWHLTLRNKYYRNMYEAFQWVALQVTAINNEKIDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X942</accession>
    <name>A0A0R3X942_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS10052</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01021274">
        <property type="protein sequence ID" value="VDM35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X942"/>
    <dbReference type="WBParaSite" id="TTAC_0001006701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="94"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1454" mass="159367" checksum="3F9280A1B1E4C4F8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9A3</accession>
    <name>A0A0R3X9A3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10112</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021320">
        <property type="protein sequence ID" value="VDM35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9A3"/>
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        <property type="protein sequence ID" value="TTAC_0001012801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001012801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
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    </dbReference>
    <dbReference type="SMART" id="SM00164">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="184"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001012801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42649" checksum="D527D4FBAFBADC68" modified="2016-01-20" version="1">MRLYWGFIHIGSDSGSLSEMDEVSNFNKMELQQALEKNENLRKKNEGLESELHDLQIGYVSLLQGCYKYKLDEALEGGKYASMPINAEHKDRVRHLLEVARRDDPRLPSASIISSHTGYTSTYGFQESFDNEETTMLYLVSLLLHTYMMNSSPEEVKVAQWNEILNSDFSLVPRARLKDLCRQGIPDGMRHLVWEQLVKLGASMFQMDMDPQYYQSLVNKVNDSQVDSSYRHQITLDLLRTFPNHIAFNRPEGFGVQKMQEVLQAFTIHNPDVGYCQGMNFIVGNATLFLDKEITFWLLVLIVEHYFPQNYFNEGLIAAQADQIILRDLISKYCPSIACAMQELEVDITTITLNWFIAAFVNSVPIENLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9I5</accession>
    <name>A0A0R3X9I5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10195</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021415">
        <property type="protein sequence ID" value="VDM35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9I5"/>
    <dbReference type="WBParaSite" id="TTAC_0001021001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001021001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001021001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133257" evidence="1">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001021001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13263" checksum="59315E437CCAB8B3" modified="2016-01-20" version="1">MQSASILLFLLLLVYASHPTLAAVVRFHDVDWQPTHWYEDVSDRRDVAQVADGRKRCSPADGVEVIGISVDPHQWRRGWMRREGGSRVRRVKRQLRFSRPIYSPRLPPTPTMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9R6</accession>
    <name>A0A0R3X9R6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021499">
        <property type="protein sequence ID" value="VDM35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9R6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9R6"/>
    <dbReference type="WBParaSite" id="TTAC_0001029101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001029101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001029101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001029101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12120" checksum="9038AB0E55E5703E" modified="2016-01-20" version="1">MVLHSESLGTQTTGTVGRSNVAKVGEETEEMRYVSSNLATIPQPSGQPPVDPSPQQLPPPPPPPPFSPNSLHPVSVGGYYWPLNTALNQPHAFKQIQQCHSNTCPFDTSEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9W0</accession>
    <name>A0A0R3X9W0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10320</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021546">
        <property type="protein sequence ID" value="VDM35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9W0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9W0"/>
    <dbReference type="WBParaSite" id="TTAC_0001033501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001033501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001033501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10034530at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001033501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="850" mass="92704" checksum="EDAB958E655D5C80" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAD2</accession>
    <name>A0A0R3XAD2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10492</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021764">
        <property type="protein sequence ID" value="VDM35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAD2"/>
    <dbReference type="STRING" id="6205.A0A0R3XAD2"/>
    <dbReference type="WBParaSite" id="TTAC_0001050901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001050901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001050901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001050901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27741" checksum="21F856BBC8E37521" modified="2016-01-20" version="1">MASKPYISLLISSSATAMSCEKRFLLNTLLSRFKENLVLITGCDNKTMKLEVRDENEKFVKELTDDSKTLEELGLKNGYHVHVTDPNIEAGLYDNIMGQDLEDRFKLSDEQYAERKDTLLAWKKQHNLGEFREVDPEERKAAEEAKLAKERYMSNSKHFRCEVRVPKQPTKRGEIAFLGETKFKEGIWVGVKYDEPLGRNDGSVDGYRYFECPPKYGAFVKPHFVEVGDFPELGLDDLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB51</accession>
    <name>A0A0R3XB51_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10761</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022204">
        <property type="protein sequence ID" value="VDM35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB51"/>
    <dbReference type="STRING" id="6205.A0A0R3XB51"/>
    <dbReference type="WBParaSite" id="TTAC_0001077801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001077801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001077801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001077801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11665" checksum="EF795DA91C89CA93" modified="2016-01-20" version="1">MTIHVNHLIALFQRLRAYLFFRRINGHSTISSRDRAQRRMACLFVIGFVLLTLLCAWFANQFLLKFSDDVSPAVKWPSGGGALEDSSSSARAALYATRGRQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBP4</accession>
    <name>A0A0R3XBP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10954</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDM35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3XBP4"/>
    <dbReference type="WBParaSite" id="TTAC_0001097101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001097101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001097101"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001097101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24383" checksum="CCB37EB1E6266000" modified="2016-01-20" version="1">MNLELLEYFFTRIEAFHQNYPEAADGHLERIKKDESGGCATFVVTIHFNRPGSLVAVGCNDGRIEIWDFVTRRIAKIIVAHSHPVCSISWSRNSRQLLSASTDNTVAIWNIVTGECERIFTFPCPVMKVQFNPRNSAEILVCPLRHPPVLIDVTTGKPIILKQEDEVRFCHWCIILRCSVLCCTILLVSYQVDSIVVARKVTFRFTSIATFVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC03</accession>
    <name>A0A0R3XC03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11063</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022841">
        <property type="protein sequence ID" value="VDM36043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC03"/>
    <dbReference type="STRING" id="6205.A0A0R3XC03"/>
    <dbReference type="WBParaSite" id="TTAC_0001108001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001108001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001108001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001108001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="626" mass="71246" checksum="AB5F71EE2564F37A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC16</accession>
    <name>A0A0R3XC16_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11076</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022880">
        <property type="protein sequence ID" value="VDM36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XC16"/>
    <dbReference type="WBParaSite" id="TTAC_0001109301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001109301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001109301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001109301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26527" checksum="510C4ED4D8FC72D2" modified="2016-01-20" version="1">MEHTKKESLEFLKARSIEVMCNPWQSNRRAPEXXXXIRWLQQSKKVPDHAAEFPNTVDPSPAFESTSTFNVAELRRILLSSSYPLFDRYQALFTLRNSAVVSAKDSTSPSSHFSEVVEALSESLAAPGSALLRHEVAFTLGQLSIAQTGDALIERLNDHQESPMVRYEAAMALGEVAESVEAGEKDSHDNSLAMRARRALLRGCNDPEPVVRDSCALALYMANYVASYERSQFAEVPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCD4</accession>
    <name>A0A0R3XCD4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ELM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11194</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023179">
        <property type="protein sequence ID" value="VDM36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001121101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001121101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001121101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001121101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14604" checksum="5953AB0CC39A80ED" modified="2016-01-20" version="1">MEGGTDPLAVYEEAVEPPCPRGVKIKAPPLQXXXXEAVEPPCPRGVKIKAPPLQTGSNTFPVDTSEENSPKANKTKWNEELSPPWTDEIAGREEEGEEEEEEVKAAVGAESEEEGRGMGKEEEEEEGQFVVRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDG0</accession>
    <name>A0A158RDG0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS553</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000054">
        <property type="protein sequence ID" value="VDM16635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000055201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000055201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000055201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20535">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048053">
        <property type="entry name" value="Cyclin-Q_second_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF495">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="160"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="253"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="578"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="813"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1247"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1515"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1515"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000055201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1868" mass="207947" checksum="9DFD0EC823B1A41F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDM6</accession>
    <name>A0A158RDM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS985</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000148">
        <property type="protein sequence ID" value="VDM17271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDM6"/>
    <dbReference type="WBParaSite" id="TTAC_0000098401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000098401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000098401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1396"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="922"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1311"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1723"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1784"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1865"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="923"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1726"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1738"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1879"/>
            <end position="1888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000098401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1895" mass="207344" checksum="C0C30D149B3CABF2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF08</accession>
    <name>A0A158RF08_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8500</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020518">
        <property type="protein sequence ID" value="VDM33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF08"/>
    <dbReference type="STRING" id="6205.A0A158RF08"/>
    <dbReference type="WBParaSite" id="TTAC_0000851501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000851501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000851501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000851501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="817" mass="91916" checksum="909261AF5BF18820" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF33</accession>
    <name>A0A158RF33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8695</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020565">
        <property type="protein sequence ID" value="VDM33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF33"/>
    <dbReference type="STRING" id="6205.A0A158RF33"/>
    <dbReference type="WBParaSite" id="TTAC_0000871001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000871001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000871001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000871001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="65015" checksum="C9B8810D76938115" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF79</accession>
    <name>A0A158RF79_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9143</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020692">
        <property type="protein sequence ID" value="VDM33870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF79"/>
    <dbReference type="STRING" id="6205.A0A158RF79"/>
    <dbReference type="WBParaSite" id="TTAC_0000915801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000915801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000915801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000915801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44791" checksum="BC85E87C730B586E" modified="2016-06-08" version="1">MGANPSHLEKKIGKDQFPSNEHYYGLVNFGNTCYCNSVLQALFFCKPFRNRVLLYRQQSKGQKKETLLSCLADLFYAVTTKKKKVGQIPPKKFVQRLKRENVLFDNYLPQDAHEFLNYLLNQIADILQAENTSEETTKKGSLAGGDADINRGENTRTWIHEIFQGTLTNETRCLNCETVRTKDEDFLDLSVDIKQYTSITNCLQCFSNTETIQSENKYYCEVCRCKQEAQKRMRVKRLPELLALHLKRFKYSENANRFIKLSYYVPFPQELRLFNTSDDASNPDQLYELMAVVVHSGSGLNRGHYISLVKSDGIWLLFDDEYVDKIDPANIRDFFGTTSEASKTSDSAYILFYQACDFSHSASTQSGATVQSPPPQSPPPSSQSLYTADSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ECG6</accession>
    <name>A0A3P7ECG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000155">
        <property type="protein sequence ID" value="VDM17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ECG6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="40" mass="4086" checksum="E7CE9BDEA0B6A729" modified="2019-02-13" version="1">MITGLSYLAVFGPLDAVFPFSLSLSGLQAGLSVTSEIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EIT4</accession>
    <name>A0A3P7EIT4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001479">
        <property type="protein sequence ID" value="VDM21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EIT4"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="29" mass="3344" checksum="EB5FB685C4D0F95B" modified="2019-02-13" version="1">MEDEDEQGWCKGRKDGRVGLYPANYVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQK4</accession>
    <name>A0A3P7EQK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005157">
        <property type="protein sequence ID" value="VDM25510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQK4"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="143" mass="16553" checksum="322FA0ED840EFFBA" modified="2019-02-13" version="1">MRQSSDVFTDGPKLASTAARSPMEVEFMREAELFFSNLESEFMWPFLQRHFFLSPQKVRCGWVSAVRFMVQHLPTDTYPEVRGCHLPRMVSGLTTTLSERMCHLSLVEIAEFIDLLVILITQIQEVSLYPRQRDGCEQPLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQT9</accession>
    <name>A0A3P7EQT9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01000592">
        <property type="protein sequence ID" value="VDM18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQT9"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="341" mass="38964" checksum="20A6E48371EBCD41" modified="2019-02-13" version="1">MLSKFKMPWVKQDYKYSCFQKLAMNVLKQGIIPTHVAFIMDGNRRHATAHGLQKTEGHKQGFSKLSEVLRWCYDFGVREVSVYAFSIENFKRSEGEVSFLMDLALNKLNDLVQNKDELHKQGVRVRVLGNLRLLPIGVQRAAARIMLMTSENFRATLNILMSYTTRDELTTTLSTIRRGVQSGILKEEYAVTWDISPELIDKSSQLRGCRPLDLLVRTSGEVRLSDFMLWQASRSAALFSFFKVNWPAFSFWHLAAAILHFQLNRSALVPLPEAVRCHLNELDSHNTANGHGGIYQPVTIDAINAENRTRRLAKFYASLEKEYMDELFEIANLPEVDETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EVP6</accession>
    <name>A0A3P7EVP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008435">
        <property type="protein sequence ID" value="VDM27400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EVP6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="233" mass="25851" checksum="9D1BDA16CBBA2408" modified="2019-02-13" version="1">MIRLLTASPKPNVSIIFDTPEASPLPIKSFKSSTGDIVQPPFATQFQPSSSTQLYRKPRRSSLVTQRHILVMAKRAAEGRTDILSREGNYDGLNYAPMHQVNLGASSSFSTIASQRAKMMVQMAVSQASQKKPRQMKRVVDDAAENFADRSFVFEDSTETSLQPMKERRPLTLESQEMRALDEVFSDFVKADPGRGVSSEVKKTLGESLVGNVVLEPSFVDALDEEWGDGFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EWN0</accession>
    <name>A0A3P7EWN0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001446">
        <property type="protein sequence ID" value="VDM21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EWN0"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050397">
        <property type="entry name" value="Env_Response_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567">
        <property type="entry name" value="CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567:SF74">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR ARCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="112"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="392" mass="43594" checksum="665135261667C577" modified="2019-02-13" version="1">MVLGFGTRLIRLHHILLSQRFGSSSALCFSSQTAVESFVLCSASEYPQGVTKSVPVLRCMPGELIGLMCVITGEANNCSAQASVTSRVAVLSRDNFFRLVRSYPQVLINAANLVCLRLSRLLRLADFAIEWHGVDAGKALYKQGDDSNYVYVVLNGRFREVHTNVDGSRNVIAESGRGAFLGYVEVTSAKPRMNTVLAIRDSEVVKMPSILLNWLKRLTPHPVSRFIQLLSDRLMQPTGGQTPSSTSFGTFASGSYTEGALTNLRAIAILATSPDINTEAFTLELQHAMSVFGSSLRLTSGMYSFFLELWPLPQCDSSLYVLHALPSRVDVLCCLFSKLTGFKSYYLKLRYLQSVVDYMKSLVRFSFQNYKIAIENVEALFQEQLDFRFSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F1K5</accession>
    <name>A0A3P7F1K5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01002317">
        <property type="protein sequence ID" value="VDM22479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F1K5"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="286" mass="32441" checksum="E65942AC6AEDC20B" modified="2019-02-13" version="1">MALSEEVQSIIDRQLATMCSTFEHNKLRKDAGRNWDRFYNRNGAKFFKDRHWTKREFRELAEITEDEDVQVNILEIGCGVGNFMFPLIEDLNSERKKPVIFYACDISPKAVANVKANLMFNADFVSVFVCDAASEDELAKSISAAPMPALLEHSSIGDVPPTISFHLATLIFVLSAIHPLQMSICLRNAVQVLRPEGKLLVRDYGLYDHSQMRFGRGARVLADRPLYRRQDGTFAYFFTCAELSQLLTEAGLTVLRCAYVYRRTENRATGLSVKRTFIQAVARKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F6W3</accession>
    <name>A0A3P7F6W3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004109">
        <property type="protein sequence ID" value="VDM24634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F6W3"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="263" mass="27587" checksum="CFAE40E6289105EF" modified="2019-02-13" version="1">MSISPAGDWVAMASEGSGGGGGGNLAVWEWRSRSPHLRAASHAANEVTSLAYSPDGQLLATGGRDAKVRLWRVVSGGRAVVTFHEHAGPVTTVAFPATKPKVLLSASLDGTVRAFDLNRYRNFRTMSVPNRDGVQFSCLAVDSTGELVACGALDTFEGFVFALRTGDLLASLTGHTAPISAVLTAGWDASIRTWSLAESESAAGGEGSGCTLLETISVPLDGEFLFAVCATTCSSLPAFDLLSSLLIESTSWRFFIVNFGNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGH6</accession>
    <name>A0A3P7FGH6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS10061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021279">
        <property type="protein sequence ID" value="VDM35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGH6"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF227">
        <property type="entry name" value="SYNAPTOTAGMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="172"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="314" mass="35862" checksum="6B0198E4F75967AF" modified="2019-02-13" version="1">MEALEENMEDNEGVTEKEKRNLGKLQFSLDYDFTKGELTVGVIQATDLPGMDMSGTSDPYVKVYLMPEKKKFETKVHRKTLNPVFNETFLFKHICSIYTRNLPLKEIFLSYKVPYAEVAGKTLRFNVFDFDRFSKHDQIGQIVVPLGSVDLARVIEEWRDLLPPDDDEKENKLGDICFSLRYVPTAGKLTVNILEAKNLKKMDVGGLSDPYVKLSLMLGGKRIKKKKTTIKKCTLNPYYNESFAFEIPFEHIQKVMLIVTVVDYDRIGTSEAIGRVVLGCNAQGAGLRHWSDMLANPRRPIAQWHTLQEMPEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FJ83</accession>
    <name>A0A3P7FJ83_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020691">
        <property type="protein sequence ID" value="VDM33863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279537at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1458" mass="161632" checksum="3EAFD1F3E99E5D86" modified="2019-02-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GND1</accession>
    <name>A0A3P7GND1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1087 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003036">
        <property type="protein sequence ID" value="VDM23345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GND1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009463">
        <property type="entry name" value="DUF1087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06465">
        <property type="entry name" value="DUF1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01147">
        <property type="entry name" value="DUF1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1087" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="139" mass="16467" checksum="5854B8F9E602C484" modified="2019-02-13" version="1">MDRSQQGMEEKQMEMNDYLSSFKVAHYEKREIQDGDSEEPEDEDPNVEVIKQELDTNDPAYWEKLLRHHFEQAQEDQAKLLGKGKRHRKPVNYWANQQEDEEEWNDNASDHDSNFSTKASHLFVPVFLKLQWGARSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI39</accession>
    <name>A0A0R3WI39_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">TTAC_LOCUS238</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000016">
        <property type="protein sequence ID" value="VDM16132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI39"/>
    <dbReference type="STRING" id="6205.A0A0R3WI39"/>
    <dbReference type="WBParaSite" id="TTAC_0000023701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="713" mass="82302" checksum="B1ED1CDF2717B53C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI80</accession>
    <name>A0A0R3WI80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS291</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000020">
        <property type="protein sequence ID" value="VDM16200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI80"/>
    <dbReference type="STRING" id="6205.A0A0R3WI80"/>
    <dbReference type="WBParaSite" id="TTAC_0000029001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000029001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000029001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000029001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15262" checksum="591F8A1F758DD6FF" modified="2016-01-20" version="1">MGIRSRTPKHARPHLLSERRSLLRQLFLGPPVTMNTYLGCVAGTDSRGGASMAGRHWPSSHPTALAATLDRISSTSNAPSSNTHMGSKMHGRTNSFDTMQTVVLTRSQLDKPWGFRIQGGQDYNLQLTVKKVCVISLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIA5</accession>
    <name>A0A0R3WIA5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS319</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000024">
        <property type="protein sequence ID" value="VDM16241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIA5"/>
    <dbReference type="STRING" id="6205.A0A0R3WIA5"/>
    <dbReference type="WBParaSite" id="TTAC_0000031801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000031801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000031801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="52"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000031801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64867" checksum="4F6746A599567576" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ28</accession>
    <name>A0A0R3WJ28_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS655</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000074">
        <property type="protein sequence ID" value="VDM16795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ28"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ28"/>
    <dbReference type="WBParaSite" id="TTAC_0000065401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000065401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000065401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="178"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000065401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38648" checksum="5CA7F09A4E5C45FF" modified="2016-01-20" version="1">MEPNPDATLSMPLLNGMAEVGEFEPPPTLSLSSVAALTLNDNDTWLRLMEQHPLVLRNLFNAATQGLRHSGGDGGNRAFIGMSELSTSLAPTEVQGGPLQAPLTLKSSPSEALLVPIGSLLASPKRPSPTSFVLESNCPFVINKLPAQNSTETFKDREDRQFSPTEVEENREDGLPVKKKIATRETTCLLKNWLYEHRKNPYPTKEEKVMLATVTRMNLTQVSTWFANARRRLKKENRLSWTTKNRTLPPQPPPPPSSATLQTLPSVFWNEDCSIVRSLATQVHSLLWSQVVKDIKSCMTKNEVEKEAPVEPTLASPPAPSTLPPSPSSTKIWSLAALVEEQPPCNELSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJT1</accession>
    <name>A0A0R3WJT1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Transcriptional repressor p66-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS946</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000138">
        <property type="protein sequence ID" value="VDM17215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJT1"/>
    <dbReference type="STRING" id="6205.A0A0R3WJT1"/>
    <dbReference type="WBParaSite" id="TTAC_0000094501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000094501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000094501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="235"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM17215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000094501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="769" mass="82063" checksum="01F0A09A3BC0A28C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL90</accession>
    <name>A0A0R3WL90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ULP_PROTEASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1515</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000353">
        <property type="protein sequence ID" value="VDM18133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL90"/>
    <dbReference type="STRING" id="6205.A0A0R3WL90"/>
    <dbReference type="WBParaSite" id="TTAC_0000152801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000152801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000152801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="12">
        <location>
            <begin position="480"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000152801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="799" mass="89382" checksum="4D9084564F22DA3F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMA4</accession>
    <name>A0A0R3WMA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps16_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1879</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000577">
        <property type="protein sequence ID" value="VDM18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WMA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000189201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000189201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000189201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000189201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23475" checksum="0D9ACC733D060FA0" modified="2016-01-20" version="1">MASMDEPGSNIWDASDVQGFSFDDCWVACLRSSLTDLRSGGISSWPIDMFVSLGAKRKLIQLAAETLDGDFLIKVILIVRSRLDRDLFFSILLENELGYKHYLHFLAETSQTSEADELMVTELKSTPSLALMHESITNAADLLKFQLKIRSEWVAFLSHPQEGPIKSMLSELEGSIVGQNLANTILACVLMDKNVSKGSRAEQLKTTFKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPC1</accession>
    <name>A0A0R3WPC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2596</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001259">
        <property type="protein sequence ID" value="VDM20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000261101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000261101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000261101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000261101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="46548" checksum="EF2950837C9CA91A" modified="2016-01-20" version="1">MDAVVVLCHFCETHGPAIIMCTQPLRQQVVPMVPSRKTSAGTPHASSSCGSFHVASTSASHESTIWPAEQLTHNLFSDIITSTAPPQSTGAVQDTNPRMQASTSCRACSIITRDEIGFVSHDFSAKTDYVSTQFPSDMELLKAVRTACMRSLSCEVIPGREGPIYFGDDINRHVISYNFFVKDSMARGFQVKYSFLLISWNQIFLLNLWPFVVKSFQTMAKRLQEAANRVYEEETSSGASSTTVASTAAAARSATPPAGTNSLRLCRTPPPSSSMAYHNTSTTPPGRGAPALLSNQAVAAGSALSLSSQATTRKLRGMRITESEVRSLAELTKDEQVYYRVHAWFTWLLRVAGRNWTPVDLKSAPVDEDEVFAEERKNGLLLGHSGGCGDTVVSGASRIPSGVVNTVDPTTLTLGSELGWTDGTPEVETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPC4</accession>
    <name>A0A0R3WPC4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2599</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001266">
        <property type="protein sequence ID" value="VDM20612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPC4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPC4"/>
    <dbReference type="WBParaSite" id="TTAC_0000261401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000261401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000261401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000261401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="12004" checksum="BB7B7B70F7EF6AC9" modified="2016-01-20" version="1">MEFQNISERIEESSRIEKANQKKTLTATERDLERRRKNNEASRKSRAQRKDRFLMDVREVEFLKIENQRLKDFLTELELVIKEANDTLIAKFKYQLPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPG9</accession>
    <name>A0A0R3WPG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2644</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001324">
        <property type="protein sequence ID" value="VDM20756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000265901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000265901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000265901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000265901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22449" checksum="B05541CB6E7602B0" modified="2016-01-20" version="1">MDGPMPISDLGRRWFSRIEIYYRLILCKNRIFCTHWGGQIIIGKANFPLIECAVRKRDCPVTDVFLTLFLQEEMLFCDDCDRGYHMFCLNPPLSQPPEGPWSCCLCLERFKEEAAANDIRIIGVASSGGCVNLIKVRFYCVVITTVVLTAVRYHWHLLTRGSAEAAEIFNGGFRSLLYRLRFTPPKRCDSMPKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPJ0</accession>
    <name>A0A0R3WPJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2665</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001345">
        <property type="protein sequence ID" value="VDM20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPJ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000268001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000268001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000268001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000268001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42425" checksum="B263E32114006650" modified="2016-01-20" version="1">MSGDRFNFDETGDTFYCFLIAVFTVILLPITYFFWPKSEVKQSPDAIKRRCQCSPCQTKRANLRSSPTKRWMKRGLIKLTIIIAWAMLIALGFRLSKIEVTMNAFDPYYELSINPDASKAEIKKAYKKLSLIHHPDRGGDEHKFIRIHKAYITLTDEVAHKNWQEYGNSDGPGAINFGMALPKWMIKKENTVLVVGVYAVIFMLMLPLVVGLWWSNYMKYSNTRVLLVTVRLFCGSFMYNPFMAVPRLIKLLSSAYEFNSQFNKDIACRPSDNVELPPLVSQIPMFTIFKRAIVGAPYAIKARALIYAHMLRLELPPKSLFIDKQYIIAQCPRLLEEMINSLLIVLSMATEDRESLCLCLVSWSRNLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPM1</accession>
    <name>A0A0R3WPM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2696</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001394">
        <property type="protein sequence ID" value="VDM20908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000271101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000271101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000271101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262148at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000271101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="673" mass="74990" checksum="7724EE4668DCDF2F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPQ0</accession>
    <name>A0A0R3WPQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2725</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001434">
        <property type="protein sequence ID" value="VDM20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000274001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000274001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000274001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10439142at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000274001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="13725" checksum="49F4C342FA199E2F" modified="2016-01-20" version="1">MRVLGANVFGVGIYVAYELKFMPAYEAESAPMVAIVVVVSAALIIISLIGCIGALLRKPWMLGVFSLVTTILALIEIGLYLTVVLLANEANETELSKIILDYAAPVGICVNLLAALQIFSGGLACAVVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPR3</accession>
    <name>A0A0R3WPR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001453">
        <property type="protein sequence ID" value="VDM21038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPR3"/>
    <dbReference type="STRING" id="6205.A0A0R3WPR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000275301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000275301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000275301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000275301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="24092" checksum="5979C247E201B20B" modified="2016-01-20" version="1">MEWGRLYLFPKFGVDAGWFEQYTWALFKAMSHMLSIGYGRFPPTSPGEAWITIISMMTGSTCYALFVGHAAALIQSFDCSKKMYREKFKQVEEYMAYRKLPRILRQKIANYYEHRYQGKMFNEVIILDELSECLREVSFRIIPLPLFNLHFQLNPFSVFKAIHAWNTTATPVNVTPQDQFVSLFCKTPIHEVTSRISQFQNQEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQY3</accession>
    <name>A0A0R3WQY3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3158</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001997">
        <property type="protein sequence ID" value="VDM22068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQY3"/>
    <dbReference type="STRING" id="6205.A0A0R3WQY3"/>
    <dbReference type="WBParaSite" id="TTAC_0000317301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000317301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000317301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000317301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22531" checksum="382DEC5F61632F27" modified="2016-01-20" version="1">MRGPGVKQHRRDGAPVPTHGLGKAPKGTQTKMSLKRRRRNKPSQAVRRWKLRSSLRRIGTIVILLAGRHRGKRAVVVGRHRTSGLLLITGPLKCNGIPVRRVHPDYVIATKTRIKMDKVDLFKPQPRSKNAADNLFVDAAAEKKAYVLKEERKEDQKLIDKRVIEAIKRSKQAKMLFAYLRSQFALSRHDKPHKMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRW3</accession>
    <name>A0A0R3WRW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3488</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002521">
        <property type="protein sequence ID" value="VDM22737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000350301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000350301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000350301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000350301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13062" checksum="4F88D6416E3C20C8" modified="2016-01-20" version="1">MRRIERLSRNFGLIFSDLSFAAEEIAALPSTSTSSCRLDVSALLDTLKKLQEALNTLTEGHLSTNSIGQMNAVFEELQDAQLWQNVFDCSSASSEEWKLVRNLRNSFHELIEAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRX1</accession>
    <name>A0A0R3WRX1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3496</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01002528">
        <property type="protein sequence ID" value="VDM22747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRX1"/>
    <dbReference type="STRING" id="6205.A0A0R3WRX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000351101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000351101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000351101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133050" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM22747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000351101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34063" checksum="3844F17E87B63200" modified="2016-01-20" version="1">MEIFLFWLLPSLFSTSAEVNAKPLGVVVWHGMGDSGFGSGVKRLCRMIMDEIPGTYVLDVKIGSSGFFDRLNSFFMPVNKQLNIVCEMIHSDPNLSGGFHLIGFSQGGLFVRALAQRCPPPKLGSVISIGGPQQGVFGVPFCPNATSVPFCNSFLKGLSRAAYTAFIQSHFVQAQYWHDPYNETLYREKSQFLAEINQEKVQNQTYKNNLLRASNLVLVRFMHDVTVIPGASEWFGFYRSDKPEDVYDIKESKQYKTDSLGLKTLDEQGRLHLIPLPGYHLQFSDEWFRKVIIRQFLKNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRZ9</accession>
    <name>A0A0R3WRZ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">REM-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3523</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002579">
        <property type="protein sequence ID" value="VDM22802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRZ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WRZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000353901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000353901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000353901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282629at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000353901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="46280" checksum="0297E870EEA682EB" modified="2016-01-20" version="1">MIIWSKQTTSRNRASSAPREAISTTSSHSVTVSSAPTTVQQSQSAALVTLQKAIAPKAVLSRTLLHRFISLKSLSDSLPVLSTGVPLEATRRSAGGNDSRGTGSHNSRGVQQLPPPTQTRRSLSRPDPMKLSDLIAWKNVEIATVQNILRVNMARAMDTALCRKSRKAYRDSVQENQKTLLRLYHESEELKAARQSVLASRSFSVGRIESPLSRLSHPLHISLTLSPAQLPHPDDSLHRTQQFNGGVTTDSSGYHADEQSSDSSHSSTNQAHGASLTISCHSSGPASTFNSVPSHRKEILSPLLCSKHSSNDVRRASSDVHYQGPHETTRVTKLPTNYVQYLFPDQTRTDSATPNHIFPPSTLSPSAYFNKSPCDVKFMSELERLTSPLSRQFAPSEATPTSTTRTRFTLADKLNMSTTYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSZ8</accession>
    <name>A0A0R3WSZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3873</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003203">
        <property type="protein sequence ID" value="VDM23644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000388801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000388801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000388801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000388801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49168" checksum="5EFADB18B3D27624" modified="2016-01-20" version="1">MQSLLVEASMESMTNLENVSFDVPLSTLANLPSVSSTTALDVPEFCEMQLCLPQFLFHSSKPSSSPVIEESVSTTTNTTAEDSDTSCPCACLQIPRQTLCLVHLRGREVSVHLYNWSRDDVDRLFHRIDSIVAWYNQRFQLMSCLSLQKMGLFHCLRTPSHLRLLRQAVLLGDRLCPPELTPTPTVAVTSSTNMASRSIRRRLLEGLVGSGASLQPPSQAISSPQAASSSVEIPIPPQLPTPSAPPSNASAGRSTHSTSPATPSTESTILQPQSLCLQQHLKIGGGSSRDSHDLHLTKIYQNCAQIPALGSRSSTGVDYLDVVHLHVDQALRTVKNDWRRAEYLRLITAPLKAWMAGDIFEVNQYTPLESQSQAVLSLPQAMTPSLTAFYSAVKRYGRTLHTVCSPILFCPRARAEALRLQQLEQVAMEKANHNLGKEEEEEGEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTA7</accession>
    <name>A0A0R3WTA7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cell division cycle 5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS3982</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003414">
        <property type="protein sequence ID" value="VDM23917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTA7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTA7"/>
    <dbReference type="WBParaSite" id="TTAC_0000399701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000399701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000399701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000091">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="14">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM23917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000399701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43210" checksum="699180F4931B9ED2" modified="2016-01-20" version="1">MPRINIKGGVWRNTEDEILKAAVMKYGKNQWARIASLLHRKSDKQCKARWYEWLDPSVKKTEWSREEDEKLLHLAKLMPTQWRTIAPIVGRTANQCLERYEYLLDKAQNIDMSSRDDPRRLRPGEIDPTPETKPARPDPVDMDEDELEMLSEARARLANTQGKKAKRKARERQLEIARRMAMMQKRRELRAAGLASTIAPLVNKNVFIDYNREIPFEKQPPKGFHDTSREFPESKPINFDRLRLGDIEKEPFMEREKRERKKDAERQAKRLESDLPGALLAREKDNGEPVVKRSKLVLPAPQISDLELENLVKVGQAGENAMRMALEDSRSDAMATQTLLSEYHKGGGNDSTFATPLHLLAKTPQIGTDTIIQVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTD6</accession>
    <name>A0A0R3WTD6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Guanine nucleotide-binding protein G(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS4011</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003471">
        <property type="protein sequence ID" value="VDM23976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTD6"/>
    <dbReference type="STRING" id="6205.A0A0R3WTD6"/>
    <dbReference type="WBParaSite" id="TTAC_0000402601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000402601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000402601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="54"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000402601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27037" checksum="9F1E8901B469801B" modified="2016-01-20" version="1">MSNELFKVRIGTTIVETEQIEYKLTSLFVFMVSFLEDLDRLGAKDYQPSEQDILRTRVKTTGIVEVHFQFKNMNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSIILFLNKKDLFAEKIKRSPLTVCFPEYPGKQTYEEAAIYIQASFEAKNRSQNKEIYCHQTCATDTNNIQFVFDAVTDVIIANNLRGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTK2</accession>
    <name>A0A0R3WTK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4077</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003618">
        <property type="protein sequence ID" value="VDM24127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTK2"/>
    <dbReference type="STRING" id="6205.A0A0R3WTK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000409201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000409201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000409201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448492at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000086">
        <property type="entry name" value="Cold shock domain-containing protein C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052069">
        <property type="entry name" value="Ca-reg_mRNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962">
        <property type="entry name" value="CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000409201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13338" checksum="E03029773A614BCA" modified="2016-01-20" version="1">MSESGEPASPLPPIPSPIIHKRNRTFSQSIRAAEAAEEGGVITSFCREKGHGFIKADNGELLFVHVFDVDGEVVPLAGDRVLFKKILIPPKNEKYQAVHVKIIDFVPERHQRWQELPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUC5</accession>
    <name>A0A0R3WUC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004203">
        <property type="protein sequence ID" value="VDM24726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000436501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000436501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000436501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="110174at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000436501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48521" checksum="18465A13C1532A9B" modified="2016-01-20" version="1">FFLRKSQILAAVGLVGGVVASCFVQPYVEVFIRWHHTQMKFGKEMKPCERVNRIADSVFAKLQVPETLRNKVDFFFTKNGEAVALGSLNDGAFKDFNDYAFIGLPYFCAYEDPLDIPIEEMNFSSPLFPYTAFSVQGRHRLQLMCLSDAALEFLIAREVCILLGSRKLTECKSSGVELASHFLPPRLASRVSCLSLVVSLYLAYQVCYVLNRLLCLPNTCVRPLCLLGYTGITALMLLCQRQLIVSWRHNASLALDAAVASVDHELLVGGIEYYEWKRSWNAFWMRLLPSSRRAMEVLRNVTRVALTTDLSPCLRYQVQRGLKDPTILYRDPATYYFIPVSIDQLDNDSQQSDLRLDDCNPAYLSAYHLPGYDPNTLQGDEKFASDGETLLFNMAGLLAFGVVPAWLASVFQLLSFPATCTKRKAALEAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV21</accession>
    <name>A0A0R3WV21_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Essential MCU regulator, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Single-pass membrane protein with aspartate-rich tail 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS4597</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SMDT1/EMRE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004854">
        <property type="protein sequence ID" value="VDM25253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV21"/>
    <dbReference type="STRING" id="6205.A0A0R3WV21"/>
    <dbReference type="WBParaSite" id="TTAC_0000461101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039145at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018782">
        <property type="entry name" value="MCU_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904:SF1">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10161">
        <property type="entry name" value="DDDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM25253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9490" checksum="033105B439D07CCA" modified="2016-01-20" version="1">MFWRGFNFFQLLTRSRMNRNHYYLCGDGVYRSTGAISDPPFQTSFGPLKVVCVVAPLLFIGAYISKTGAKFLEDNEIFVPKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVG2</accession>
    <name>A0A0R3WVG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein Asterix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4737</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005206">
        <property type="protein sequence ID" value="VDM25555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVG2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVG2"/>
    <dbReference type="WBParaSite" id="TTAC_0000475201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000475201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000475201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM25555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000475201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7611" checksum="94BFF5FA04858D34" modified="2016-01-20" version="1">MSFLGMILSIGSVMFESKWCAWIAIFCALGTFGNARASDDVKHLATMAVLAVCVLVMSYFHNPAPLTIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVK7</accession>
    <name>A0A0R3WVK7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4220 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4782</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005316">
        <property type="protein sequence ID" value="VDM25633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVK7"/>
    <dbReference type="STRING" id="6205.A0A0R3WVK7"/>
    <dbReference type="WBParaSite" id="TTAC_0000479701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000479701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000479701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000479701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24218" checksum="85D467E5F3E0DC4E" modified="2016-01-20" version="1">MGENEEAATSEHTLVPIETDNMSETSNKEESNAAPPSTRDGKEELVHMENLYASWSEDDFPNKSDQGRRGINKLLGFYVDARSVLLKKGPPVQDREPICCDGIVGLFGLLFLLLADIAYVAYACFYQGLDKDGDVHLLWMSAILWFVILVKIARRLVRLAHSNGGCWTVFAKMAQLYHVIVNGVVRVLTAPWRAIWNNVSGDEATIQRKKDLTMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVT0</accession>
    <name>A0A0R3WVT0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ephrin RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4854</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005495">
        <property type="protein sequence ID" value="VDM25767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVT0"/>
    <dbReference type="WBParaSite" id="TTAC_0000487001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000487001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000487001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000487001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="18920" checksum="D2DCC04CBC41C5C9" modified="2016-01-20" version="1">MLQEKACASASPVCGGMKYLYCVPTSAGAKFHQLLQLTGPDGAHPDTCMIVVKDDPCSNSRIPQVDKGEGNRTLQHNTPLHTTPHTARSPLLTSCRLYFSAKSPLRPNPPLARPREQNRMESGLLPCDGNSSPETCSQLYLSEQKCGGLCLTPSAPASVVGFAMCHMCHKSVYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWC5</accession>
    <name>A0A0R3WWC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C4H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5050</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006072">
        <property type="protein sequence ID" value="VDM26152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000506501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000506501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000506501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044069">
        <property type="entry name" value="ZF_C4H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018482">
        <property type="entry name" value="Znf-C4H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058:SF2">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10146">
        <property type="entry name" value="zf-C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51896">
        <property type="entry name" value="ZF_C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C4H2-type" evidence="2">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000506501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14972" checksum="8322DDC394A0D317" modified="2016-01-20" version="1">MMGTHIFHQLLFFSGSVERQRHTSNQSLRLSDVLLGCGVNVAPQSGNYSGTPAPPPPPSQPQQQQPPMKTCQACQQLIHRNAPICPLCKTKSRSRHPKRPKVRGALAQLPSTSVTPIPSATPTVVQTSTSPSNTTIEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWG3</accession>
    <name>A0A0R3WWG3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5088</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006213">
        <property type="protein sequence ID" value="VDM26233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WWG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000510301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000510301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000510301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000510301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22295" checksum="C91D03801A915E2D" modified="2016-01-20" version="1">YPDQGSVLGAAACRSTETLCIDDYLIYLQKIGFDGPDEGQIDELNFLFQANHLPISVFQPNVQNRDRESSASQTFPTPTTSTSCATVKPGPAEIDLASHLVVSVKPEQDDLLLTPQHASSVDEFTLDTESSENVTDFTPRKPSVSKRTLESFEGACSTLGCTRMPSEYLDLSPSPYGSVVRSLQCYTESGSPPPAPFITRAALSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXD9</accession>
    <name>A0A0R3WXD9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007413">
        <property type="protein sequence ID" value="VDM26930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXD9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXD9"/>
    <dbReference type="WBParaSite" id="TTAC_0000542901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000542901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000542901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10345954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000542901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10187" checksum="4429D41BDB120C2E" modified="2016-01-20" version="1">METSPIHQTCWVEKDQDGANYTYYWLGPDQRRIADGSNLTVDYALRSRHSGAYTCVAKSMQAAHRDLEGTIFVIVSRKSHLHRISKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXY4</accession>
    <name>A0A0R3WXY4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Treacle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008211">
        <property type="protein sequence ID" value="VDM27318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXY4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000562401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000562401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000562401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000562401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40280" checksum="5989B034D3ADF5A6" modified="2016-01-20" version="1">MQMLSGAPAKRSGGKEASSTKHHEKKISECVELEEKDVTSVDSAAVPIETTVVECEPANAEHQGTAKSEKKSSDSKKKRGKKKSESSPGHRKPSLEAQEPVIPPDSTASASKREEEEEVMEFKEGGAEHSVDALMTSASDSPVPLGGIQEKVKAAKKSPTPSDKRRNKGTSESSSLNMEATADPLEAHEFHAMSSEHLKGKGSAIKRKRDKEPVGPVQTKEEEFSNIAAGTASSTMESPVPPNTETESPQEGQKPPTKKSTDNVEKGKKTKTKLLEASAKQKTSNQQRCSVSSTTKPKASKESSRQTTEASLEAEESGMTFATADLPEQAEVLKPGKRRRGKESKPAKEVGERNISTKKAETSTLSKDSDISEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYN6</accession>
    <name>A0A0R3WYN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009392">
        <property type="protein sequence ID" value="VDM27818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYN6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYN6"/>
    <dbReference type="WBParaSite" id="TTAC_0000587601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000587601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000587601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256093at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133130" evidence="1">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000587601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19834" checksum="FACEB58E2EA8B4EB" modified="2016-01-20" version="1">MNEKVVVLFILGMGAVRLYEDYMDEVDRDDDEEEDRFKKRKISRRDVRDELVPPANTFEMVVEVQQNRFFEGSTKSCGDVGPLNCSCRRLFCFGGYCKKLEKYHRRSAFDVRSLNISSVFTPAHPVWVKICRQTVLWGQNLCECRRYLSSWDSVKYDITAFVNGKEFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYS2</accession>
    <name>A0A0R3WYS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5897</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009594">
        <property type="protein sequence ID" value="VDM27912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000591201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000591201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000591201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000591201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18930" checksum="2957977056D6348A" modified="2016-01-20" version="1">MQCAALPVSVYLKSIKGCSNSRRVSSYLRRHWLQEAEEGEGGSERAVNEAALAGVSGQNSVAARQRAFSDPRAPCPHLLYHQQHNQHQQQNPLRRHPPPARHSVAFFDAPSPVSPKFSALHSPPPQTPSPPLPISPISIKDKYRAIFDLPLGAFVPSSLTLVILLFCLIFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYT4</accession>
    <name>A0A0R3WYT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-processing factor 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009661">
        <property type="protein sequence ID" value="VDM27944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000592401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000592401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000592401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000592401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11373" checksum="D2B516D6DDDC61A7" modified="2016-01-20" version="1">MPHRGAIGSVGYKYAKETLGIWQETGVYQQMIPALYKRPRSGSSSSSGISGTHRKSRSVSIGVAAAPPKLGKAATADETAEQPSSLPDSSVSEISVKRVSNPLLGSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYU7</accession>
    <name>A0A0R3WYU7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5922</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009740">
        <property type="protein sequence ID" value="VDM27974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYU7"/>
    <dbReference type="WBParaSite" id="TTAC_0000593701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000593701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000593701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000593701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="9423" checksum="C56F7CAC4248F38C" modified="2016-01-20" version="1">MSHETCGHVNPSGSNCDDAGGGGVGCGGGGGGGGGRRLLLIPTAHSTSYSKLLHRTPQHHSNRKARKDANSHFDGDNAGGAGADACASGDARIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYY9</accession>
    <name>A0A0R3WYY9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5964</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01009993">
        <property type="protein sequence ID" value="VDM28073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYY9"/>
    <dbReference type="STRING" id="6205.A0A0R3WYY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000597901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000597901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000597901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM28073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000597901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6803" checksum="66FBFDE662903334" modified="2016-01-20" version="1">MDSNPDDVKLLDFIQNKFTCCGVVGVEDYWESRVPSSCGATIAERTQRPVSKVPTQTPTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ29</accession>
    <name>A0A0R3WZ29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AA_permease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6005</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010178">
        <property type="protein sequence ID" value="VDM28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ29"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ29"/>
    <dbReference type="WBParaSite" id="TTAC_0000601901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000601901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000601901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000601901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14087" checksum="9C741B397020B583" modified="2016-01-20" version="1">MSKSLILAVGYQFYSDLFSLIELAGFAFAFIAALAVGALLYMRYKEPNLKTSFQVHLSSTFASLPIFFPILFLGCDLLILVLTIYQQPRESLSNVILMLVALPIYWFGVSWKNKPKSFQKFICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZF3</accession>
    <name>A0A0R3WZF3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6157</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZF3"/>
    <dbReference type="STRING" id="6205.A0A0R3WZF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000617201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000617201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000617201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000617201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="573" mass="65035" checksum="875409EE6835AB7D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZZ4</accession>
    <name>A0A0R3WZZ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein asteroid 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6392</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZZ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WZZ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000640701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000640701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000640701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000640701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="748" mass="83669" checksum="DAF47DAB0ED3E870" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X004</accession>
    <name>A0A0R3X004_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6403</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X004"/>
    <dbReference type="WBParaSite" id="TTAC_0000641801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260926at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133072" evidence="1">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29775" checksum="E83A06701B764A42" modified="2016-01-20" version="1">MFFLTLLVVGSIIPSTRSIYHAQRCCIDWVEPCKCPRLYITEDLRPCGSEIQIEDLIMPMARFQVSDDVRLHSYFYTVVFLLTNRHSESTEGLRFRLVFAEINIPRDRFMGILSNTVEDNILDAKNQMIVNELSTFRFTSESVPVDSLTRLTAFLISQSSYLDFYKTNFTGLPANRIILRRELKYLFPGESIAAASHSISALQTLEAGTTVTSDSRLTISQENWIPNKITEGIDIVDVETGGAKIKNHFHEWFMGQRNATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0G4</accession>
    <name>A0A0R3X0G4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS6606</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0G4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0G4"/>
    <dbReference type="WBParaSite" id="TTAC_0000662101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000662101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000662101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
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        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
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        <property type="entry name" value="Galactosyl_T_N"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
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        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="104"/>
            <end position="199"/>
        </location>
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            <begin position="251"/>
            <end position="316"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM30840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000662101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45147" checksum="F54EE75FF3AABFDE" modified="2016-01-20" version="1">MARSGRRALCLLTSILLIALGGVLTLTLFDKTSKWRFAGSDGGNESEKAKQVALVSELQALAQLANRTVEEFAMEVLAQQDRIRSTFCANGSTAAETPLEFCEEACTASEQPRVLMVFPIRDRWELLRSLLRKLLPLLNRPTVCTFIAIVEQTDALAFNKGLLMNAAAMEMSKRVPFDCIIFHDADLVPVDGDEVYYECPSYPRHLTVKVDKFRYRKVVIIITFTKVLTSTPILIYSHLDKCLQLFALIGDLPYLNLIGGILALPLQHFLRVNGFSNMFWGWGAEDDDMFERLSFLGIPITRPMVNPTRYTMLPHRSSERLDAWRTIVLLKMALRRYRLDGLNSAQYRTIRTNLTTTCDVIGENRSECRFGKKYIMHLLIDPQPITAPNVNIFYNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N1</accession>
    <name>A0A0R3X0N1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6690</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000670501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000670501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000670501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273453at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000670501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1301" mass="143519" checksum="3C67932990E1C7FB" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X158</accession>
    <name>A0A0R3X158_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Laminin subunit alpha-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS6894</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020329">
        <property type="protein sequence ID" value="VDM31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X158"/>
    <dbReference type="WBParaSite" id="TTAC_0000690901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000690901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000690901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011303at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000135">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="16">
        <location>
            <begin position="561"/>
            <end position="817"/>
        </location>
    </feature>
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        <location>
            <begin position="871"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="987"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1034"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1081"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1133"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1181"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1275"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1323"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1703"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1806"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
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</entry>
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</entry>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000719201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36243" checksum="52D43F7BDEAB5E16" modified="2016-01-20" version="1">MFLSLDHFLLQFLSSDDAHSTYSLVEDLFGEIIDILLLISNWLTVAVAVERYLAICFPLYVRCFSHRAQKRIVLCIIFTAIILQFPSLAKYWSVLDSLSIALSYFNLWFTRVLVLLIFPCTILICVNVRLIQTIRSSFILKHCAFASTALDCPSNDGSTSECKSNISRSTRPMVPFTLNGSLTRVVGQHASREERAIIINLTCLIAAFFLCQFPFIFLSVAFKLYESDMDNVAFRGANVTLLQKTFLCNKDSINQTLHLPTTSTTNAIASTATVFIGTELDILAYVRALSVIFLMLKGDLYFLLYCGLCGNLSRVLRSFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1T7</accession>
    <name>A0A0R3X1T7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">REJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020351">
        <property type="protein sequence ID" value="VDM31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1T7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1T7"/>
    <dbReference type="WBParaSite" id="TTAC_0000719901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000719901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000719901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242292at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000719901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="130653" checksum="BD934FDD6521DA3B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1T9</accession>
    <name>A0A0R3X1T9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7187</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020351">
        <property type="protein sequence ID" value="VDM31526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1T9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1T9"/>
    <dbReference type="WBParaSite" id="TTAC_0000720201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000720201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000720201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000720201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22298" checksum="93339462AF6BC110" modified="2016-01-20" version="1">MTSTAVNLSPNCGDSEKESGTLKGIPKATFIEDVDDYLKTNGYATIRDAMQALDQIYQKYKLMEQAFLQRKLRLLQQMPDITKTLDVVRHLEKKNEDFDVTFEVSDQLYARAHIDKADKVGLWLGANVMLEYNLAEAKDILLANLSSAETSMADVEETLAFLKEQTTTVEVSLARLHNLNVKRNQAAAAAAAIASANGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N4</accession>
    <name>A0A0R3X2N4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-3CxxC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7546</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020382">
        <property type="protein sequence ID" value="VDM31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N4"/>
    <dbReference type="WBParaSite" id="TTAC_0000756101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000756101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000756101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000756101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21751" checksum="6F880CE8D25B49E9" modified="2016-01-20" version="1">MIGATVMKARYDSPIGAMPSICTCESCINDYLYVYEKRNVAGLLSLPVSSAEVSKEVGEDFYFWLQQNIHIVWIGTFYRLFVYPTNMAWHLQPFDSPAEVPSSSCIWGVTESAKVRFTCTDCGKVWTSISALASFALCVELEESRPKWNLWFSLHGQTCSNCVSLGYTPKPHYGTWYPHEVFRVSTLNLTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Z9</accession>
    <name>A0A0R3X2Z9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020394">
        <property type="protein sequence ID" value="VDM32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Z9"/>
    <dbReference type="WBParaSite" id="TTAC_0000769601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000769601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000769601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6237288at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000769601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130140" checksum="AD9DAF0EB2A8E610" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3N7</accession>
    <name>A0A0R3X3N7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7958</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020425">
        <property type="protein sequence ID" value="VDM32436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3N7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3N7"/>
    <dbReference type="WBParaSite" id="TTAC_0000797301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000797301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000797301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000797301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14317" checksum="96EFD065F9454BA6" modified="2016-01-20" version="1">MRNIHLQDVNADVVNCITSAYRSKEFLIYDYPGSPIYHDLFDKFVDAIDAFVLMFDVSDRTSFEACPLWAQKVKEVAKGVSVPGILIGNKTDLIFRRDITEAEAKRFAEEAGIKYYELSIVSHAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3V1</accession>
    <name>A0A0R3X3V1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8032</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020434">
        <property type="protein sequence ID" value="VDM32518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3V1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3V1"/>
    <dbReference type="WBParaSite" id="TTAC_0000804701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000804701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000804701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056818">
        <property type="entry name" value="GlmU/GlgC-like_hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24894">
        <property type="entry name" value="Hexapep_GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide" evidence="9">
        <location>
            <begin position="314"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000804701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46360" checksum="71A5DE713C66C39F" modified="2016-01-20" version="1">MQAVILALHDSSYLRQLTTSGIVGQLPLGKQGSLLSNLVGVFESAGIVDPIIICRSGDSKHIEKCLSQSHSCIIVEVSATLSIPECLYRVRDHFTCVPFAQYVFLTYADVAVTELDLRDLFLRMVRTKAEIVALASPYTADAKLLKMARGTHDLMVLDDKDESLVMYVPALELKKQIRIPKSIMSSHSNLTCRADLHDVGLYLLSGYALRMLEYDRDDAGLRKSFFKHIVNVEQHKSFQFDTNSMTSQIPKSLRYSQDEMSQYAKVVISVLENAPVCRRIDSASSYLDAVKMLREKYPPENTKVEKSAPAGSASDRQVGKVVDTMQGEGCSFAVGALIRSCIICSNCTVGQGTRLFSSVLLSGVAVGIGCKVTNCVIGEGATIDDGCNLKDCTVAAHQRIPAKSVMQSENMGFSEIDFDNLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3W6</accession>
    <name>A0A0R3X3W6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5 18">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 18">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS8049</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 18">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 20">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the SepSecS family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="5 18"/>
    <dbReference type="EMBL" id="UYWX01020437">
        <property type="protein sequence ID" value="VDM32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3W6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3W6"/>
    <dbReference type="WBParaSite" id="TTAC_0000806401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000806401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000806401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259324at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098621">
        <property type="term" value="F:O-phosphoseryl-tRNA(Sec) selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001717">
        <property type="term" value="P:conversion of seryl-tRNAsec to selenocys-tRNAsec"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10 18 20" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18 20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 20" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
        <ligandPart>
            <name>tRNA acceptor arm</name>
        </ligandPart>
    </feature>
    <feature type="site" description="May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate" evidence="20">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="20">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDM32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000806401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="571" mass="61833" checksum="DC8D0B447A9FC04C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Z8</accession>
    <name>A0A0R3X3Z8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8086</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020444">
        <property type="protein sequence ID" value="VDM32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Z8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Z8"/>
    <dbReference type="WBParaSite" id="TTAC_0000810101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000810101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000810101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="147"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000810101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="605" mass="67721" checksum="6784DA44BFDBA090" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B5</accession>
    <name>A0A0R3X4B5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8228</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020468">
        <property type="protein sequence ID" value="VDM32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4B5"/>
    <dbReference type="STRING" id="6205.A0A0R3X4B5"/>
    <dbReference type="WBParaSite" id="TTAC_0000824301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000824301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000824301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000824301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="42794" checksum="A2543E91891B68D7" modified="2016-01-20" version="1">MQSAPIIQGKESAEKTARSIFVGNIPYEATEEKLVELFSKAGPVVSFRLVYDRESGKPKGYGFCEYANPAIAASALRNLQNIEFNGRPLRIGAAAGEQNSAEIALTNPSVGPPLENPYGNPVDPAKAPEAISRAVASLPPEQMYELMKQMKLCIQNNPNEARNMLLQNPQLAYALLQAQVVMKIVDPKVAIAMLNRTHDQIPPLRPENVPSGMCKLPESGVGGGGDVNKPPQQSFSAIPMNGDQFSNHPSAFPGEFPPEQLQQPMGGPGMYGGFQPPPPQQPQPHQVPGGFPHLPHPSPSGPLGQPSAFSVGAPQPGGPPQPTTAHSTSGISSLDQLNPAISAALKAGSGGNVTGLPQKEEEKLGLIMQVLALSEEYIAQLPEDQRRSIRILKEQVGKRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B9</accession>
    <name>A0A0R3X4B9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8232</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020469">
        <property type="protein sequence ID" value="VDM32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4B9"/>
    <dbReference type="STRING" id="6205.A0A0R3X4B9"/>
    <dbReference type="WBParaSite" id="TTAC_0000824701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000824701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000824701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14801">
        <property type="entry name" value="TrmI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000824701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55109" checksum="942A93576CE48161" modified="2016-01-20" version="1">MEKKSTNIQNAKPFWDPISLYTRQDKIPKDRVFEKECECVAIVEANTESHHKLETSERPTPSHLKRPFRKNIAAEGDTVIVTYCKNEIQLIKLRRGATTQNKCGAIKHNDVIGKPYGSRIATSVGRVVILALDPAIWAISVPHRTQIIYPIDASMIVGQLDLVPGCRVLEAGTGSGALTHALAQAVWPTGHVFTFDFHQERVGRAIMEFEVRTSEHGLKDVVSVEHRDVLSDGFPEAGSPLNPDGCHAIMIDLPEPWIVIPTIAKCFTSSGGRVCVFSPCIEQVQKTCTNLRSAGFSDIEVIECISRNYDPVHTVLNVPNLGETLIIFTPNCKLSDKLLPPLGDIMGRAVGQIMPSSFPADDRRNAAVVYQMQLRDASRNQTPFACSLLGQENATDLFNGTYTYNKTQSAEATEADGEARKASQRRNERHLFPPLSNYLTPNDNAKGSGQGYRQYGYWAALPRQKDTGHTGYLTFASSIPMVTSVDNSPCDIDNQGDGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4G1</accession>
    <name>A0A0R3X4G1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020477">
        <property type="protein sequence ID" value="VDM32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4G1"/>
    <dbReference type="WBParaSite" id="TTAC_0000830001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000830001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000830001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000830001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11475" checksum="7A79F53561977EC6" modified="2016-01-20" version="1">MTDGVDMSTTIINLEVTLFPLFQPITWRLWCLDLQHMCRHGDSSDLCHPEAEFDEKWGDSPSLPLREWKDSDEPLDVQMFDEMVNGEVETDAGECANWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4N4</accession>
    <name>A0A0R3X4N4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8366</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020491">
        <property type="protein sequence ID" value="VDM32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4N4"/>
    <dbReference type="WBParaSite" id="TTAC_0000838101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000838101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000838101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000838101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7080" checksum="8B0C1E8169BFC917" modified="2016-01-20" version="1">MPTMEGLGGTGPDIRSGLLAADFGDGTGPVGLLMECAKATERQANLIILQKSAFDSIAHLRSQREHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4W5</accession>
    <name>A0A0R3X4W5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8459</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020509">
        <property type="protein sequence ID" value="VDM33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4W5"/>
    <dbReference type="STRING" id="6205.A0A0R3X4W5"/>
    <dbReference type="WBParaSite" id="TTAC_0000847401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000847401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000847401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000847401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43595" checksum="5E2DAAB6EECA92AE" modified="2016-01-20" version="1">MSVLQKIAEIEAEMARTQKNKATMGHIGLLKARLAKLRRELIEPKGGGGGGGGEGFDVAKTGDARVGFVGFPSVGKSTLLTNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGKQVIAVARTCSLILMVLDVLKPLQHKRLLEHELEGFGIRLNKEPPNIFFRKKDKGGINFQSLVPLTELDKDTVKTILNEYKIHNADITFKCDATAEDLIDIVEGNRVYIPCIYVLNKIDQISIEELDIICKVPHCVPISAHHKWNFDELLEKMWDYLSLIRIYTKPKGQLPDYTSPVILKSTAHTVEDFCNKIHRNIIKEFKYAIVWGSSVKHQPQRVGKDHVLDDEDVVQIVKRCVFSFVHNFTPKLTFDRLELTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X564</accession>
    <name>A0A0R3X564_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8573</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020535">
        <property type="protein sequence ID" value="VDM33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X564"/>
    <dbReference type="STRING" id="6205.A0A0R3X564"/>
    <dbReference type="WBParaSite" id="TTAC_0000858801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000858801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000858801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="4"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000858801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46462" checksum="89DF24EE2025FF2B" modified="2016-01-20" version="1">MSTGHLDTELTELGEIQATNLGDSLKNLQIDGIFTSDLKRASYTGEAIQRSYKRKPIPLFTNPLMRERNFGLNNGRPRSKVHEFIAETKSNHMGCQMWREYQGECSHQVGSMFRINLMQCLRLQFHLRFYSVSWEIWAIHNDYQIFWRALNFFFDLCEFAANQPTKPTPDFGSIGSVERFTGTDISPLPILLPIHQPPVSQAFAFSRRQPRNKCASSSTEEISHEIMDYAGHFILVSHGQWIREFNHILYAFSEHSLGFPAQRQMLAVLENCQFNQFGVAVHCKQLATRATRLRAAVGSALKAARDCRSHSCPYDLGHFADPLPIDTVCYHARVDAHTVKGSITTAPAVETVEEKPAVSACSGTETLFFAREDDEYAGLPMTRWVDQNYLRTFHEPIELALIVSPIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X646</accession>
    <name>A0A0R3X646_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8950</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020634">
        <property type="protein sequence ID" value="VDM33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X646"/>
    <dbReference type="STRING" id="6205.A0A0R3X646"/>
    <dbReference type="WBParaSite" id="TTAC_0000896501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000896501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39162" checksum="A8A0B087C03A7136" modified="2016-01-20" version="1">MQAAGDLDGINPDSGHSSVKSRESADGSLDDVQSTSAHQFISPVDETDGSLENRILRQIEFYFSDANILKDQFLLRSVRSNKEGWVKLSTIAAFRRVQTLTNDEDVIRRALKSSAQIEISDDGKNVYSYLVLGMRIRRKHPLPDWDKSVYSKSILITRFTEADVVTVFSSMNLDVKLVRIVDPGRVIPRDLVKSASLIGFLGKEKCAVVEFDSRESALRAIGVVKNTWPNSYCTILHLYARPQISLTSCVYSDVKVELVRDSRSPPNENSVGFETNWREALSFHRLNMEDSNENSSCSISISSDEFFTPQAPSPRAPISPSTVALSSSVAQPASQLMCFDEAIVSVIPTASSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X674</accession>
    <name>A0A0R3X674_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8982</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020646">
        <property type="protein sequence ID" value="VDM33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X674"/>
    <dbReference type="STRING" id="6205.A0A0R3X674"/>
    <dbReference type="WBParaSite" id="TTAC_0000899701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000899701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000899701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000899701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32440" checksum="5B8236098F7DA894" modified="2016-01-20" version="1">MGQDQSRQEKFFDACSYGREWLVKEMIAEGIDVNWKSNIHDCCPIHAASQGKPDIVRLLIQAQCVVDARDINGNTALHHAALSGHVECVKVLLEAGASVNVSNNQFWTPLTNAAYWNQPEVMKLLLERGADPFWKNKDGRNPLHELCRSKSEKKDDLVICLRLLVTRMRELEMVSDSEKTKAVTQNGHVDSVAPGGTGKMQHRQVMMLTDWIPLKPGDSSIELRSSPTNAWDSEDDCYSLLLWFYAFRDALPAEMHKLDGVDPSQKKGHSTVWHTYHLIVLKDADLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X730</accession>
    <name>A0A0R3X730_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron-sulfur protein NUBPL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9327</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020763">
        <property type="protein sequence ID" value="VDM34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X730"/>
    <dbReference type="STRING" id="6205.A0A0R3X730"/>
    <dbReference type="WBParaSite" id="TTAC_0000934201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000934201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000934201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000934201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="30486" checksum="EE2F887B92EA80B6" modified="2016-01-20" version="1">MFGRMFSTFVSEHARSVMRKGLPKKLPIAGVDSIVLVTSAKGGVGKSTIAVNLAVALSRLQASNQVGILDSDVFGPSVPELMGVNGIQPDTNEQKQIVPLQNYGVKCMSIGSLVEKESAAIWRGLMVMKAVQTLLRQVAWGPLNTLVVDTPPGTGDVHLSLVQNVPIKGSVVVTTSHPLSLSSTQRGIEMLLKLNVPIIGMVENMASFMCPNCKIATPIWCAADSTEEVGAAKLADQYGIPLLCRIPFDLDFANKKGNSLPVVISHPNSLTATAFVELANQIHSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X794</accession>
    <name>A0A0R3X794_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9402</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020801">
        <property type="protein sequence ID" value="VDM34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X794"/>
    <dbReference type="STRING" id="6205.A0A0R3X794"/>
    <dbReference type="WBParaSite" id="TTAC_0000941701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000941701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000941701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257855at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133203" evidence="9">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000941701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22218" checksum="98B7C65DEA640300" modified="2016-01-20" version="1">MYLILLIFTISPQINAYQLCSDVGYGDLECEFNSSCQYGQIVNVMCKSLIPCRSVSNASDSVHFRQTVCRYCHQLTKKSDFFCKPPSGECAQPGVARSYYVAKCHANPAIVCMGRREFLRMLPCTQDSGKNYGTTVILSLFLGGLGADRFYLGMWREGLGKLFTFGGLGVWSIVDFVLVVVGYICPADDMTYWRNIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7B5</accession>
    <name>A0A0R3X7B5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS9425</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="UYWX01020811">
        <property type="protein sequence ID" value="VDM34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7B5"/>
    <dbReference type="STRING" id="6205.A0A0R3X7B5"/>
    <dbReference type="WBParaSite" id="TTAC_0000944001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000944001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000944001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000074">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
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        </ligand>
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        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000944001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26754" checksum="78896303881426BE" modified="2016-01-20" version="1">MIWFPIILPTDCKIHGHSRRLPCSSQVWIGPSVLNGDLSSLADLSVKLIDSGADYLHLDVMDGHFVPNITFGHPVVSCLRPKLPPGTFLDLHMMVSEPEKWIEGMRQAGATQYTFHLEATDDVKRCIRKIREADMKVGLGIKPKTVVEEVFPYVDLVDMILVMTVEPGFGGQAFMADMMSKVKALREKYQDLNIEVDGGVCPKTIRECIKNGANMIVSGSAITNADDPAAIIRSMRSTIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8E8</accession>
    <name>A0A0R3X8E8_HYDTA</name>
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        <submittedName>
            <fullName evidence="3">Transposon Ty3-I Gag-Pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9808</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021066">
        <property type="protein sequence ID" value="VDM34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000982301"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF435">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000982301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8043" checksum="9E80F073D27F4A8E" modified="2016-01-20" version="1">MLRNNAIRPCQSPWASSIALVKKSDGINSSDSQQGAKKFSALNLKSGYWQVEVAEKDREKTAFVVPTGLLGFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J6</accession>
    <name>A0A0R3X8J6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRP1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9856</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021112">
        <property type="protein sequence ID" value="VDM34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0000987101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000987101"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000987101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="15557" checksum="A24E9DE3C392B09A" modified="2016-01-20" version="1">MANDSDEPDSANQSWLATQLRQAKQMRLRKQQEKQEGGGFVNSTTGSLGIHAVASAGTLSRTQGADMMSDLQRVLAARRRAREGDNDNTDGTATDAANGASASSGSANSTAESSHLRRPSQSINNSSSGNAAPTFAVPTAPAPTSNYATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8L8</accession>
    <name>A0A0R3X8L8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9878</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021127">
        <property type="protein sequence ID" value="VDM34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8L8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8L8"/>
    <dbReference type="WBParaSite" id="TTAC_0000989301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000989301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000989301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20048">
        <property type="entry name" value="FH_FOXD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF402">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000989301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31237" checksum="B3CB0D167EA8E9CC" modified="2016-01-20" version="1">MVTNSIFSTSVFEQLLRNVNVNRTFAVPPLRNIFPIGHTISRSPSQAEAVLSQLSDSIIDLTDEGVLYKSSSVDSVSIKPPYSYIALITMAIMQSPNQRLTLSGICEFIMQRFPYYRERFPAWQNSIRHNLSLNDCFVKVPREPGNNGKGNYWTLDPNSKGMFEHGSFLRRKKRYKRHYQRSLCGIGSRSGSLSLAAPMAVSTLTQYPHSLVCPHRARPWVIDAEQRTFLPPIYYPSVVESSSATIVKKVTSLHSTTTQTAPSLSFSIDWILGPSDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8P8</accession>
    <name>A0A0R3X8P8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9908</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021151">
        <property type="protein sequence ID" value="VDM34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8P8"/>
    <dbReference type="WBParaSite" id="TTAC_0000992301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000992301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000992301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000992301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38417" checksum="52B0571AFA1AAD95" modified="2016-01-20" version="1">MQTDLSPRWMEYIHDEGVVNLHSVEGSQSAMEVRTQHTSDEYYVDWGADVPVVHHGAPLGHSSATLGGTADFWRPVASEFWHQAVCMRPALRVHVRLRFLYPRASSDLCVLALPALPAPLVSIVCIFGSGDQTATYRLFERSIPSITQYAGTLTDIVILTELDLGAVEAEEREKEQIARLNGRRLCFSYQSRQKGPQITTTQDILPQPLDDQLLRLLSACPNVSSLSIGGRLLNIHLTTASQICRLLVKAARTKPRSGGSAKKPPPPVLRVDVGSIRLSGPIPQSATERDSNVFLELMRDCRGKEVETLVAKERAAECLIAAALGSPRWQFMETDEFRRHVLNYPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Q6</accession>
    <name>A0A0R3X8Q6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CASP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9916</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021155">
        <property type="protein sequence ID" value="VDM34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Q6"/>
    <dbReference type="WBParaSite" id="TTAC_0000993101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000993101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000993101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000993101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9745" checksum="0EEC651D95699BEA" modified="2016-01-20" version="1">MRTRSRADDDDDDDGLGVVAAAADVGGGDAANVRITQPSGCTHWLSAKRFATFSASISHLGVCAFIAAGTVVGLQNAIMFWYVNKVRRVIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X941</accession>
    <name>A0A0R3X941_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10051</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01021273">
        <property type="protein sequence ID" value="VDM35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X941"/>
    <dbReference type="STRING" id="6205.A0A0R3X941"/>
    <dbReference type="WBParaSite" id="TTAC_0001006601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR-like C-terminal" evidence="4">
        <location>
            <begin position="215"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33234" checksum="2B01C260D5855B60" modified="2016-01-20" version="1">MQSAALRSGLTTHLDGARALDELLQRWIAQITSAAALEKVDLKSTSPSTAVDGSTLKTSSPSPVVPPPPPPPPPPPPPSRHALRPVYPFQPRSLRGTQYLVPQQSSSAVGPKATLSKWVQNLGVCEVYIIFGFINVPFVLSVNLIFYMQSEFFCVCELRHLETSLSEECPLPHLWPTALRYLFSQFVSTTLSGRRRISFSAYSSPCLHCHLCFSAPQHAIRCDGFVGVALEINTSLVHVSLGTSLCEWGSIYLDSYGEEDLDLKRGKPLFLNEDRFALLESQWMSHSFRHVLKPWRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9I3</accession>
    <name>A0A0R3X9I3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Usp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021412">
        <property type="protein sequence ID" value="VDM35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9I3"/>
    <dbReference type="WBParaSite" id="TTAC_0001020801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12478" checksum="67F82B6A42A43C5B" modified="2016-01-20" version="1">MDGADWIIWLDSNQRRQRAHGKVASDTPPLSSLSAPLLLHKAVLVVVRACGRDEMVVLAHHVAWRLAVSVAVTQVATMPWPGGLVSELMPSRKFRDVEETVYFPTPPILTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9N6</accession>
    <name>A0A0R3X9N6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAB6-interacting golgin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10246</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021469">
        <property type="protein sequence ID" value="VDM35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9N6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9N6"/>
    <dbReference type="WBParaSite" id="TTAC_0001026101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001026101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001026101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001026101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15719" checksum="3E073A1AC2BE0301" modified="2016-01-20" version="1">MENRSKSVEKKLEELLGEPSKERSEKKFYSSNADAKSPADSGIQLITCEDLPVRLNDAQQLLHETRIQSLLKENAKLNGELKSMQQNEADFENAAREVRTFLLRAEEDKKRLMNRIEKLTANARFEDAKKKQIIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9T0</accession>
    <name>A0A0R3X9T0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021512">
        <property type="protein sequence ID" value="VDM35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9T0"/>
    <dbReference type="WBParaSite" id="TTAC_0001030501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001030501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001030501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001030501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13189" checksum="B1398E66B8C7AF9D" modified="2016-01-20" version="1">MMHRRRHGVHFKSWANHEAGLISTIERFDACLYYSELAEDFYLVKLLILHGLSSFCLHEFRDMSVRTVSRNAPPHCFSEGDGTCKLLVRTTTSQWDGHFKRLLEIDAKAIHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA48</accession>
    <name>A0A0R3XA48_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10408</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021665">
        <property type="protein sequence ID" value="VDM35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA48"/>
    <dbReference type="WBParaSite" id="TTAC_0001042501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133261" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="61"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23036" checksum="AEAD287DC9A67D0B" modified="2016-01-20" version="1">MHVATFFLLILLSAIQAHAWWSHECCKCPGLDDDDTSFFINFTGGIDEEDSQEPAPTNLSKEKRKLLDLQNSYRRRVARGQVPGQPPSSNIHDLKWSTELEASAQRHADTCQFAHDSNEARRTARWDWVGQNIAYSSSVAQNVEMWFNEYKDYNYSSNYCSGVCGHYTQVNITRMGGHHTCRVWGEQMQFRRVRRGLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAB2</accession>
    <name>A0A0R3XAB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10472</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021742">
        <property type="protein sequence ID" value="VDM35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAB2"/>
    <dbReference type="STRING" id="6205.A0A0R3XAB2"/>
    <dbReference type="WBParaSite" id="TTAC_0001048901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001048901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001048901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF81">
        <property type="entry name" value="HOMEOTIC PROTEIN DISTAL-LESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001048901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="54837" checksum="2BF9AD512D5F23F9" modified="2016-01-20" version="1">MAEDRTPVPRMCEQTSSVQLPCVDGTSNGHFNLPDLLPNMTAASPIGEEGSDFTNLPAQNFLEEMTLLPSDSHLPIYHNGALHGPYNPIYYGSSSSGSNAYPDDVHTRYILTPVQDTRGSTSPLSQEELLHHPTYHGGINLTQDAVTPTTVISSLSTSPNDYTLATSTTGSVTDSGGGGGGGGGQEANRGLGNRRKPRKPRTIYTPAQLERLNSRFAKSKYLNLSERAQLASDLGLTQTQVKIWFQNRRSKLKKRGVQITDNSDGSSNNLEESRTETTSDDQNSQSTLPRPSSAESINGFSNPQGNSCPVSTPNWSYTDRPSPGLTELSTEVGDITRPAEHLMSHPSQTMAITYSTASYTMPTTIPSTSSGALPVSCVGYFQPSMTNQDSTSLRGSFEWQSGMRQEVNSTLPSTSSWEASSRAVQSQSQASHPVMSLYGCTHRSSTPQQQQQAPQQHSHSYPPQWSGGDSNYNQIASTDMPISYGYAPTYTSSTWQSQTEAVETDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAX5</accession>
    <name>A0A0R3XAX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10685</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022053">
        <property type="protein sequence ID" value="VDM35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAX5"/>
    <dbReference type="STRING" id="6205.A0A0R3XAX5"/>
    <dbReference type="WBParaSite" id="TTAC_0001070201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001070201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001070201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="11">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001070201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="656" mass="67921" checksum="2FE06C62E5B2A213" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB99</accession>
    <name>A0A0R3XB99_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10809</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022270">
        <property type="protein sequence ID" value="VDM35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB99"/>
    <dbReference type="STRING" id="6205.A0A0R3XB99"/>
    <dbReference type="WBParaSite" id="TTAC_0001082601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001082601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001082601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001082601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21111" checksum="10428A7741F1DA6F" modified="2016-01-20" version="1">MLLSEISIAILIACLGIATNAGILIFSRMLGVGPRKKKYSVGGYSTDETYSDHRPQRTGSLDSSAPRRVSETTSRFLASKKPMMLVPNADVSLLRLSSLLSINRLEQDMNLPQRYSKPSGKMTWRSQSRRHRVYLQGLLILASSNLLTAFLLLISAMYSIYKTNVSIAGILTTSALLDAFQAVEVGAILWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBS6</accession>
    <name>A0A0R3XBS6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10986</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01022671">
        <property type="protein sequence ID" value="VDM35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBS6"/>
    <dbReference type="STRING" id="6205.A0A0R3XBS6"/>
    <dbReference type="WBParaSite" id="TTAC_0001100301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001100301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001100301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NADP transhydrogenase beta-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001100301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19458" checksum="C121CA0524E62FB1" modified="2016-01-20" version="1">MLGTHRETSVEAVGGLLEDAKDIIIAPGYGLCVAKAQYPIAELVKLLTKRGKRVRFAIHPVAGRMPGQLNVLLAEAGVPYDIVFEMDEINADFPKADVVLVIGANDTVNSAAEEDPNSILAGMPVLRVWLAKKVIMVKRTLGVGYAAVDNPVFFKENTDMLLGDAKKVCDGLLAHFQEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC82</accession>
    <name>A0A0R3XC82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11142</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023050">
        <property type="protein sequence ID" value="VDM36122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC82"/>
    <dbReference type="STRING" id="6205.A0A0R3XC82"/>
    <dbReference type="WBParaSite" id="TTAC_0001115901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001115901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001115901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001115901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7778" checksum="B731C5779EEF7EF4" modified="2016-01-20" version="1">MRCEQGQPTEPTRPPPTNKRFQQTQAQVNEVVDIMRVNMEKVLERDAKLAQLDDRAGGYFFIVTIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCI9</accession>
    <name>A0A0R3XCI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zpr1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11249</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023378">
        <property type="protein sequence ID" value="VDM36229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCI9"/>
    <dbReference type="STRING" id="6205.A0A0R3XCI9"/>
    <dbReference type="WBParaSite" id="TTAC_0001126601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001126601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001126601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001126601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14231" checksum="46F2DA0652BEBCBC" modified="2016-01-20" version="1">MSLFVNPDIPYFQEVVLMAINCSLCGYRSNEVKSIAGIAERGKQFRLLIATEEDLSRDILKSDTASVALPELGIDSEPGTLGGHFTTIEGLLVLIRDKVRPSVLLSLNACSTLHMHLSKVDLRVYALGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCZ7</accession>
    <name>A0A0R3XCZ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11407</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024036">
        <property type="protein sequence ID" value="VDM36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0001142401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001142401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001142401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001142401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11397" checksum="3AABB333870226C4" modified="2016-01-20" version="1">MGPLNLRLTHVEGQSYKLQWKTDPPNSKGVNTLLLVLKESSGSGAQIREIADFSSGEFTVRNLRPQTQYTLLVTGLADDVQHWSVSGKFTTLPDGKLVHFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD27</accession>
    <name>A0A0R3XD27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11437</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024190">
        <property type="protein sequence ID" value="VDM36486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001145401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001145401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001145401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001145401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9563" checksum="A30A24E0DD10A52F" modified="2016-01-20" version="1">MHQLIHXXXXVPSHSIVKSATNLGVDRMDPQVVTSPPSNDQLGGASHTPDNLEPTSPVQVGGSLQFPAFCPPSLKLLITLNEIERGVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE07</accession>
    <name>A0A158RE07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE07"/>
    <dbReference type="WBParaSite" id="TTAC_0000642601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000642601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000642601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000642601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144796" checksum="4F54AB1CBA656308" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE65</accession>
    <name>A0A158RE65_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6694</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE65"/>
    <dbReference type="STRING" id="6205.A0A158RE65"/>
    <dbReference type="WBParaSite" id="TTAC_0000670901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000670901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000670901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="81"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
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        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000670901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="870" mass="97728" checksum="94DBC6531C74B7EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REE8</accession>
    <name>A0A158REE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 184A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7155</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REE8"/>
    <dbReference type="STRING" id="6205.A0A158REE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000717001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000717001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000717001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000717001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48711" checksum="DA209275A4760113" modified="2016-06-08" version="1">MSVNVTETLLNESIGTLNNVIIHNSTTFISNDFLFLETKVARALAGTVAFLAVIITCHQIYLHIVNYTAPNEQRWIVRILFFVPLYAFQSWLSLMFLRHQDFYVFLSLCYEYLGGESCIMAEIRGKKIPYSWVFCTCCFSGQVFTIGFLRFCKQATLQFCLVKPLMAVAIIVMQLIGVYKHGVWSWSNGYFYTTIIYNVSAFLALYALVLFYLATSSILRPFDPVLKFGIVKSVVFLCFWQGVILAILEKMAILPALPYTNVGTVAAGIQNFLICFEMLVAAIALRYAFPHLLYSVGVNTRRQYDEVDEGDDINADNGSAGEKCGLIGGNIWKNGDSVISVGHPSGLHNLKDTFNPRDMLRDALHNFHPTYRQYTEQRTHPDYSSIKEKPSTVSPSGTTPAPPIPPVPPSGVDLAGGNHSASSRQQVNAPPDRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REK1</accession>
    <name>A0A158REK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">IF rod domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7428</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020372">
        <property type="protein sequence ID" value="VDM31804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REK1"/>
    <dbReference type="STRING" id="6205.A0A158REK1"/>
    <dbReference type="WBParaSite" id="TTAC_0000744301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000744301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000744301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="132"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="6">
        <location>
            <begin position="618"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="383"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000744301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="84292" checksum="65241D42505688DF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E421</accession>
    <name>A0A3P7E421_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000026">
        <property type="protein sequence ID" value="VDM16273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E421"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="9">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="595" mass="64090" checksum="E2DC5C8B81BDF46D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EA66</accession>
    <name>A0A3P7EA66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000381">
        <property type="protein sequence ID" value="VDM18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EA66"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="99" mass="11437" checksum="8EF80F9976739E51" modified="2019-02-13" version="1">MFRTTKVTGSNVYAIHRNSFFFVNAPRFFPFQLDRGKLSALFSTFYSHACVDNCVFFFNQKTQISKSSQNIEIEMSFVSPFHSRTVNQIYNLRLTSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EJ42</accession>
    <name>A0A3P7EJ42_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001519">
        <property type="protein sequence ID" value="VDM21193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EJ42"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM21193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="413" mass="45657" checksum="C9EEA12D19291785" modified="2019-02-13" version="1">MSTEDTDCSVDRESGTQTAVYLETAPLLCHVYRLVSGDEADPTHETLEVSSEVIRGGTRWALPSSAFDGLWDSLVYDSSVKRDLLKYSESALIFSDYEVSQHVIAWNRVIFLHGPPGTGKTSLCRALAHKLSIRLSHRFTSAALIEINTVNLMSKWFSESARLVSQMFSSIFEYVEDSNHLVFLLVDEVESLTSVRKSVASACEPSDALRVVNAVLTHLDQLKHCPNVLVMATSNVSGIVDPAFLDRADIRAYIGPPSAVAIYSIYASCLNELIRVGLIERQKSGLLNYRVLSALQFVESSVTAPSLAVWRLAQRSVGLNGRALRKLPLLAHAFHMDSKYRPIQAPLQAKQRVTNNDDSENVSPQRTSASGSERNSSSAVPFLVFVEALQRAVNRRFSDQQLITEYMGDSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EPL5</accession>
    <name>A0A3P7EPL5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001817">
        <property type="protein sequence ID" value="VDM21776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EPL5"/>
    <dbReference type="OrthoDB" id="5832575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039139">
        <property type="entry name" value="CCDC170-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863:SF6">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863">
        <property type="entry name" value="TSEC-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="305" mass="34840" checksum="305BF8B31C853B94" modified="2019-02-13" version="1">MASLSEVKDGKADLADANSDTALTIKKLQNEQRNFRQWTSKLVEQLKLENMENEEEYPLLMDAIAVRVKALVTNESEKIATQRSRLAQLQQRNHEFRERNDAMEIQLTLLRRRLASLEDGEAETRKRLASAAAMDRVHKRLNRQLEQARAEVYALQAENDRLKNESNGERQNALAAVGTNALLHAAESRVNDLQAQCERLENEAQGLRREKLHLETSSNSTVRNMQKRIANLEDELDKVRRSECQASKVMLKRLLEFRVVVARLLNFECDNLSVPDFEIVHRLEQVVLALDSPGIQGLHKSAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EU13</accession>
    <name>A0A3P7EU13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003077">
        <property type="protein sequence ID" value="VDM23406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EU13"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="74" mass="8032" checksum="FE4D60C57A3FE82B" modified="2019-02-13" version="1">MHELTNFAGTLRGLKTITSGPKAGGQSRSEEDELMHRRSPGGEGLVFLYASVKRMHKSIFGDLKGVEQDPICGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EVM2</accession>
    <name>A0A3P7EVM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008362">
        <property type="protein sequence ID" value="VDM27370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EVM2"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="147" mass="16705" checksum="5E33F1EA79FE8A06" modified="2019-02-13" version="1">MHPPPFRLGSLVFNTPNRIVEGAEVYLQCEYFMGPRPFCGFTVLISFVEESKLSRAQVEVAASTQFLVPDGLRDAHKRFGEVVNKTTCDLAMKRLESVLVTMAFTMSRRRAGSYICQLVPLNETSVEVRTLTKWMRLELRRGKVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EYQ6</accession>
    <name>A0A3P7EYQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001641">
        <property type="protein sequence ID" value="VDM21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EYQ6"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="522" mass="58066" checksum="7920C0F7FE47ACCD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F8Y4</accession>
    <name>A0A3P7F8Y4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridine nucleotide-disulphide oxidoreductase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004585">
        <property type="protein sequence ID" value="VDM25057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F8Y4"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM25057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="115" mass="12597" checksum="4C0EC2429DA0D431" modified="2019-02-13" version="1">MHFQTDYVNVPTTVFTPLEYGCIGLSEENAISKFGKDNIEASAFTNRPHCASFNNSCLDNRVVGFHVFGPNAGEVTQGYAVAMRLGARKEDFDHTIGIHPTCSEVSHTLRGTEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FF79</accession>
    <name>A0A3P7FF79_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020982">
        <property type="protein sequence ID" value="VDM34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FF79"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="179" mass="20011" checksum="2EB6000F0BD6035A" modified="2019-02-13" version="1">MRFNEKENISSVNTAKNSVSKAIRSRVTENLEIAKDYLERILPRKEPLKLLNHDHIELFADPSGEVIFFRQRDGPFVPSLKLLHKYPFLLPQLQIDRGAIKHVLNGSNIMCPGLTSPGAKLCDVPANTVVAIMAEGKENAVAVGVTVLSTREMLDVNKNVGVETLHYLNDGLWQMKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FM70</accession>
    <name>A0A3P7FM70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025667">
        <property type="protein sequence ID" value="VDM37340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FM70"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="118" mass="12483" checksum="E3CBF146CC1B7CE2" modified="2019-02-13" version="1">MLFSAQEAKKISNLESIREKLLSSLDQYAKLLAGDTTFAEPDEALIQQLTAAVGAEKEQTAAVGAEKEQVTEGGRISTSAQPLAQANTGENLASFFTSPVSESEKSIPFGNDPFSTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FW55</accession>
    <name>A0A3P7FW55_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020418">
        <property type="protein sequence ID" value="VDM32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FW55"/>
    <dbReference type="OrthoDB" id="6224711at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="455" mass="51020" checksum="43B58D956311C90B" modified="2019-02-13" version="1">MFITLGRVGPQKQWILPQRCYRCQFLRRIFFQIFIVLSPQLEEAKLCDGITELQLQNYLVPSLPLSCLVDDDFIAGFCHRGSLSSTFSSWFGLILDSCFMVDASTPNLAMLSCFHPNFYSVGICFILGVVDIIPLAHHNDLEVFVRKNMLTINMSASVYSAFGLAGVKFMCNNRKMYHFNIHLGWPTFKRNDNAHMRLRNFFNSEEVTSRRPPGPCVVRWAVNKNIDWTRVENGGLPEAPHPYSLARFLAPDFRIAIPTVEVCNLEAGAEVPRFIEANSSVDHPSGSSVDHESARIAHSTLQQMAAGVYPANDSYLSPLSSRRVSAFAPGEAICLRGATILTISGIFTLEQCQKLEDLLTQVQVNLVDVDSSVLCFTLDSLCFSEVVRTSPSENSVAFFASRQIESDWFPSITEKKKDGHSPVFFQKLLAPVFTASRPYVLTLNFVPELTCEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GTF8</accession>
    <name>A0A3P7GTF8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004891">
        <property type="protein sequence ID" value="VDM25292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GTF8"/>
    <dbReference type="OrthoDB" id="10343822at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="55" mass="6394" checksum="D19EE1E2ECA707B4" modified="2019-02-13" version="1">MHLRWSKLPPPYWTKVYIHGNLNGVEKDEKSALSLPNGHQTSENGSDTLRYRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HA90</accession>
    <name>A0A3P7HA90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020377">
        <property type="protein sequence ID" value="VDM31878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HA90"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="63" mass="7066" checksum="2708C55CB81BAF9E" modified="2019-02-13" version="1">MRFLQIASLYQGVVGSIPPDESCKPGQKWDSGYVGGCSVLRSRWQGNEVDEGRHLFLIKPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HAH5</accession>
    <name>A0A3P7HAH5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020383">
        <property type="protein sequence ID" value="VDM31958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HAH5"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="73527" checksum="BCBF5714C8BDFE90" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIE1</accession>
    <name>A0A0R3WIE1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS362</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000029">
        <property type="protein sequence ID" value="VDM16309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIE1"/>
    <dbReference type="STRING" id="6205.A0A0R3WIE1"/>
    <dbReference type="WBParaSite" id="TTAC_0000036101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000036101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000036101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000004">
        <property type="entry name" value="40s ribosomal protein s9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="BACK" evidence="13">
        <location>
            <begin position="155"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="14">
        <location>
            <begin position="807"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="663"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM16309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000036101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="996" mass="112866" checksum="D80E8018BF5C886A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIT6</accession>
    <name>A0A0R3WIT6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS535</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000050">
        <property type="protein sequence ID" value="VDM16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIT6"/>
    <dbReference type="STRING" id="6205.A0A0R3WIT6"/>
    <dbReference type="WBParaSite" id="TTAC_0000053401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000053401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000053401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="5">
        <location>
            <begin position="545"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000053401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="774" mass="88500" checksum="464CC96886223AB7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIY5</accession>
    <name>A0A0R3WIY5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS597</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000062">
        <property type="protein sequence ID" value="VDM16719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIY5"/>
    <dbReference type="STRING" id="6205.A0A0R3WIY5"/>
    <dbReference type="WBParaSite" id="TTAC_0000059601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000059601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000059601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="7">
        <location>
            <begin position="618"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000059601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128980" checksum="3572348D46C476D2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ18</accession>
    <name>A0A0R3WJ18_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS641</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000071">
        <property type="protein sequence ID" value="VDM16780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ18"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ18"/>
    <dbReference type="WBParaSite" id="TTAC_0000064001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000064001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000064001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="78"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="268"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000064001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59982" checksum="1060E1F1B9AA0F70" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK30</accession>
    <name>A0A0R3WK30_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kish</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1059</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000169">
        <property type="protein sequence ID" value="VDM17391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK30"/>
    <dbReference type="STRING" id="6205.A0A0R3WK30"/>
    <dbReference type="WBParaSite" id="TTAC_0000105801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000105801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000105801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000105801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="5099" checksum="3B309CFDBE45E692" modified="2016-01-20" version="1">MPDILDRHKTGFTGTFWKCARIGERKSPYVAICCIFLALLILVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKV6</accession>
    <name>A0A0R3WKV6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neural proliferation differentiation and control protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1362</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000276">
        <property type="protein sequence ID" value="VDM17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKV6"/>
    <dbReference type="WBParaSite" id="TTAC_0000137501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000137501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000137501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000137501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18370" checksum="E9558D75D5477681" modified="2016-01-20" version="1">MNCLDSAEIPSIQPFDVDTFEDEEHLGNESDIGAMQICGFHPKTGSPLQAATPISIEEQELAWEQCSAVYNVALVTVVGVVILVHLAFLFYALWGAIKRACVNQTHLRTEGVDVVGEDETPLTYTPEYVWYVKDGKLPLKGLTQEDFIDFERYAHFVYAQSHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLM4</accession>
    <name>A0A0R3WLM4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000427">
        <property type="protein sequence ID" value="VDM18339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLM4"/>
    <dbReference type="WBParaSite" id="TTAC_0000166201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000166201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000166201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000166201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15946" checksum="82E33105CB026984" modified="2016-01-20" version="1">MRIQAPVVGADPRGGFRPTANVATTRVQCQRPIQFSLGGCLEEEEEEEWIVAPQWVGVAANASPFGHHWVNPLHVAVNGTIGTKAPQFQYVSAFRLIEHLGRMLTPPQHLCHLGGTWCQAVDSQCRVGGATRDAVLGGWWMEPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMJ1</accession>
    <name>A0A0R3WMJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THO complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1966</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000644">
        <property type="protein sequence ID" value="VDM18706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMJ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000197901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000197901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000197901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="4">
        <location>
            <begin position="336"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="359"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000197901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="945" mass="105989" checksum="743678667D4E78A0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMS6</accession>
    <name>A0A0R3WMS6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2051</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000716">
        <property type="protein sequence ID" value="VDM18791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000206401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000206401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000206401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF7">
        <property type="entry name" value="PROTEIN PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Pecanex C-terminal" evidence="7">
        <location>
            <begin position="264"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000206401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65156" checksum="22EF20BA66A98C9F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN43</accession>
    <name>A0A0R3WN43_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2168</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01000817">
        <property type="protein sequence ID" value="VDM19111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN43"/>
    <dbReference type="STRING" id="6205.A0A0R3WN43"/>
    <dbReference type="WBParaSite" id="TTAC_0000218101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000218101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000218101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM19111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000218101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48845" checksum="AC71B555821BE131" modified="2016-01-20" version="1">MSVLLETSLGNVVIDLYTEERPRCSLNFLKLCKVFYYNGCLFHSVQRNLVAQTGDPSGTGRGGSSIFEQLYGEQARFFECEVLPKIYHKKRGLVSMVNNGSGQHGSQFFITLADDLDYLNNKHSVFGTVAEGEEFLSKINDAYCDKESRPYRNIRIHRAIILDDPFPDPDGLEVPPSSPKFFRSYEDPDGMAPPRIEEDEDLDGEADGRELTESERAEREAMKEARTNAQLLTLLGDLPDVDAKPPENVLFVCRLNPVTRGEDLEVIFSRFGEILSSEVIYDRRSGNSLQYAFIEFARKEDCEEAFFKMDNVVIDDRRIHVDFSQSVAKEWFRYRREKQHALPRPSPQRRRRLRSSPLSSSRSRSKRRERTPKNDDKELVRTTPERQDMEYLLSDQEESDSVSSPKSPKRKKYAKHRKYGCGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPH0</accession>
    <name>A0A0R3WPH0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2645</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001325">
        <property type="protein sequence ID" value="VDM20757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPH0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPH0"/>
    <dbReference type="WBParaSite" id="TTAC_0000266001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000266001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000266001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000266001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46156" checksum="7A28187D92781C77" modified="2016-01-20" version="1">MTALEFEDGSVGFRQKIVLSILSSQPIHIKNIRHKSKEPGIRPSELDLLKLISEISNGVIVKLNDTGCDVFFSPGTLIGGEVEFTCSTERGLGYYLEPIVLLSSFTKVSMILTLNGITNNLIDPSVDVVTQSWLPFLKKFLPPASASSLKIVIKKRGVAPKGGGRIIFTSKPATFLSPIQLIIPGKVYRQDGLIDLDLHHLSRVRGVAWACLVSPGIASQLMYGAKKLLNSFLSDVYINIDHRKRGVGGESSGFGMILWAETKEGVFYTAEVCSAAESDTAVSVVPTIPSELGFEAASRLLNQVYLGGCVDESLQSLALSLMALEGGRNASQLLISEPTPHTIQTLRLLHKIMEVTFDLTYIDRVKLNEKKEEGGANESAGIGLQKEKVNPMNAREEGEESSAECPVPLVAICFGSGLKNINLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ54</accession>
    <name>A0A0R3WQ54_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2879</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001628">
        <property type="protein sequence ID" value="VDM21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ54"/>
    <dbReference type="WBParaSite" id="TTAC_0000289401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000289401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000289401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10621623at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000289401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13863" checksum="DE2B174BB5D7BDC5" modified="2016-01-20" version="1">MEKAKKIMYADICKYLNGSDIVSVCEALPHIKCILFSKAIVEVLRKYVSTMQWVDATVYRWIYSAISMSKSAESEKTNEEEAELLYKVIQCYRDDRQYRKNFIRYDLPCTDRVFHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQD3</accession>
    <name>A0A0R3WQD3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001734">
        <property type="protein sequence ID" value="VDM21610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQD3"/>
    <dbReference type="WBParaSite" id="TTAC_0000297301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000297301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000297301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10599196at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000297301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12433" checksum="2DC38004A9FBF51F" modified="2016-01-20" version="1">MSNVLHALKANHDECDRHCQDLEDEVQALKRERSRLRQQSSVQDLIRSIRQRQVTLQRDLMNSRQLEAENAMQRRLLSKLSSERDALVSVVRLKAEMHCFGWTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR25</accession>
    <name>A0A0R3WR25_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Novel acetylcholine receptor chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS3200</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002059">
        <property type="protein sequence ID" value="VDM22141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR25"/>
    <dbReference type="STRING" id="6205.A0A0R3WR25"/>
    <dbReference type="WBParaSite" id="TTAC_0000321501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000321501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000321501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040399">
        <property type="entry name" value="TMEM35A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163:SF0">
        <property type="entry name" value="NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13163">
        <property type="entry name" value="SPINAL CORD EXPRESSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM22141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000321501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15385" checksum="B2BBAEE5055A380F" modified="2016-01-20" version="1">MSDVALKSISIIIGGFFILFGVLKVVPLFSTDLYRDVRGIFERSAKVFPLQQFTGWRPKADSLRRFYGAVEMVCGVVLMVGQENIADLANMALIVLLFFVLFANWALGEGLKEASHAIVLGLVLTCRFVIRLQVTLDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSC2</accession>
    <name>A0A0R3WSC2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3648</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="UYWX01002798">
        <property type="protein sequence ID" value="VDM23063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSC2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000366201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000366201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000366201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132984" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM23063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000366201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14734" checksum="6AA84A94D8594844" modified="2016-01-20" version="1">MLLTLAVGLVCVAGLNAEKLKEVEVEILGVPCRKFVQKGDYVHVFYVGRLYESKKQFDSNVGGEPIRITVGGGQVIAGWEEGLVGTCEGERRRLRIPSSMGYGARGYGDLIPPDSDLEFDIEVVRIDKRKEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSE7</accession>
    <name>A0A0R3WSE7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3672</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002840">
        <property type="protein sequence ID" value="VDM23123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSE7"/>
    <dbReference type="STRING" id="6205.A0A0R3WSE7"/>
    <dbReference type="WBParaSite" id="TTAC_0000368701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000368701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000368701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000368701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43223" checksum="D98E643AE0758C61" modified="2016-01-20" version="1">MSKYPHPQTYLFTATLNKDVRSLRRVALRKDSVICTPTTAAHMLSKSQPFVSVDLPAGLSHYCLPTRRVDKLACLEWLLEKTGDVRTLVFCARCHETRYLAGFLVERGYKAVGLMGKMKQLERRRVLAEFVEGKANILVATDVASRGLDLPLVGLVINYGVPLTTKSYRHRVGRTARAGRSGTAVTIVTRDEGKAYLDLESALLPTKPKESRRCIPRWPHQLPPEEGKQSDGEIGMEKRRRLADEAWSRAAKAIREAESLRLIEEERKRGDYSTFSSSEDENAFDDFDTMDEVELGNQSWASGAAGIAAYAEAMRRRKQQRRNKRATVMDGKEAEEEDAAEAISGDDSEVDEEKGNLHFDQPIKENWAARRKKNNQAKKPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSG0</accession>
    <name>A0A0R3WSG0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3685</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM129 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002870">
        <property type="protein sequence ID" value="VDM23151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSG0"/>
    <dbReference type="STRING" id="6205.A0A0R3WSG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000370001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000370001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000370001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055027at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018801">
        <property type="entry name" value="TM129"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10272">
        <property type="entry name" value="Tmpp129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000370001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45107" checksum="5968381E893B7439" modified="2016-01-20" version="1">MPVTLRFKPTGEEFVITFGYALFIFALVAPPNVLLSSGLTIEKLFHRLLGSEELSFTAYHLRRTALLTVLSALIPLGNAFGDPELGLLNAVGNAGLALSVALVVTVFSYIYLEWYAHGKWTGHPGMQAMKKIADHISSSSSLLSSVNSDELEFLRSHPSPEGVASSIDQEFRRMEKFIAFAGRGLTSSWSGRRIVVTPSWILFSYRTTFLPICQLLGHLGAVVVGTRWINNQMASFEEEQEQTDLVLGSGVVMATIRIADMDSGACMLSFDLPASELENFRLYLRCPLVYAQGVSLEPNIIQRFLEAFSTAVQENEPIELPSSMELERCIGCLNTQTNVAIRRSCAGKCGSCRCRPMWCEMCVGRWFASRLAQSHVLTSEWLASRVPCPTCRSLFCVRDVLPLSRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSN0</accession>
    <name>A0A0R3WSN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002986">
        <property type="protein sequence ID" value="VDM23294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSN0"/>
    <dbReference type="STRING" id="6205.A0A0R3WSN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000377001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000377001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000377001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10553830at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000377001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="20608" checksum="6411CBB5B3D888CF" modified="2016-01-20" version="1">MDFSTNVGETGVFTNSSAHQQFQAKMFSSMDYSPTTAATAAAAISMGQHRCFVEEMSYSTDNGSGSSNSSGSNVAEAKRPSYQPNGGSIKAASGDLLRTAMPSVGRGYGAIMDGQEGYVPTSGGGRRERRDADSDGGLSHVSKRGKCPKGTSEDSSARSSSMIGGQMTFQELTTMHGKPMDFAIRGQTSQVSLILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSV8</accession>
    <name>A0A0R3WSV8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Effector from type III secretion system family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3832</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003122">
        <property type="protein sequence ID" value="VDM23504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSV8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSV8"/>
    <dbReference type="WBParaSite" id="TTAC_0000384801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000384801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000384801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229420at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000384801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30387" checksum="CC3B79443D59393B" modified="2016-01-20" version="1">MAPKLIQSTNEFQIGISDVVNAAKNSSSVDLVAQKERFDAVFDAGLSDFQRDFINNSSAAAAVRAKEALQQVVYKFSAGSADSTAMKDFLETLEKTSVELPFIRSTISDVLNSECTVDQLSTCRGLLFTTDNDLKLTYTLEQFQSSQVANLLTTLESNQQNVKNLDNFTETLLRMKEDVKKTIQPILDEIVKVITNSASSNLAIIIGWLTLTNSFIEVIYTQCPSDAWNDLSNSPKTRENLVKSLELVAETARSFLAKFNDIIANYISSDSSYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSX4</accession>
    <name>A0A0R3WSX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Basigin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3848</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003146">
        <property type="protein sequence ID" value="VDM23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSX4"/>
    <dbReference type="STRING" id="6205.A0A0R3WSX4"/>
    <dbReference type="WBParaSite" id="TTAC_0000386401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000386401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000386401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970915at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000386401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37292" checksum="C28EA2728FE7EFFD" modified="2016-01-20" version="1">MLVLAGRYYRFEMLLLQILTALTISSFFGNAIKVEPSENVILPTYMTNIQYESIQFQKRAKNASHLSPLNFIITDLRCKDVKISLMSNNKSIAVGRFDERTDAYADKRFDSNGVLTHLSIYFKQSAANSGTYILTVEACSDSGSAEIQVLSAPILPIYSKPKRVLQGDPLRISCRVSGFPCPDGVQWLFAPISTELSDDKAAISDASANLKPINLLDDLWKDASFVTEDGTPNDTLRFSAITVAQNGLFACNVSNILGSDSTFLLVGVKDRWAALWPFIGIVVEVTVLVAAILLYERHQIRKKPAAPETTGNPDATSPNGNAVDKIPKPDEVRLRNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT51</accession>
    <name>A0A0R3WT51_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3926</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003305">
        <property type="protein sequence ID" value="VDM23776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT51"/>
    <dbReference type="WBParaSite" id="TTAC_0000394101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000394101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000394101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000394101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12732" checksum="A7EA6167983024AC" modified="2016-01-20" version="1">MLAPVNAILSQLSDLSNLASKRVCVETRDTRHLTRHACGTWSALLEVEALWVHITHPPTSSSSLFEAHHQLVLDVRRFGCRMAFEHYYCFVDCCAVDMNGRVVEEEEEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTL6</accession>
    <name>A0A0R3WTL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003646">
        <property type="protein sequence ID" value="VDM24156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000410601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000410601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000410601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6234980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000410601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18666" checksum="4C29A816CCE5A366" modified="2016-01-20" version="1">MTGGGRGPNLHRRFEEQPATTNGLYGFEVLSQMRMAKAQAIGRALACCLPPVIPVKRPPCRRRPLLTDLVAVNPRVDYFVAPRLFSFREPPYTPIANKRSSIVDCLLLSDIYLGDRCSEVKPRLVECRKRNTSGILVAKSSKVDYFVAPRLKSSREVPWICSCNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTT1</accession>
    <name>A0A0R3WTT1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ionotropic receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4155</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003792">
        <property type="protein sequence ID" value="VDM24309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTT1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTT1"/>
    <dbReference type="WBParaSite" id="TTAC_0000417101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000417101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000417101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280926at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000417101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14243" checksum="DE7964CAAB1A0073" modified="2016-01-20" version="1">MSSPQSGPVEYLYALGYILSGNDDFANLMTNRIDAISTDQTFNSIEMRTLGMGDCPLPSEKINMQHNPFSLRELGGLFIIVLIGIIIAFIVAGIEFVIQKYPMYRQWKKDGDIRFGESYPSEVVAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU45</accession>
    <name>A0A0R3WU45_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAF-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004052">
        <property type="protein sequence ID" value="VDM24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU45"/>
    <dbReference type="STRING" id="6205.A0A0R3WU45"/>
    <dbReference type="WBParaSite" id="TTAC_0000428501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000428501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000428501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000428501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17209" checksum="1AAB2B920BB5839B" modified="2016-01-20" version="1">MLSLHESVYLERAIEQSESNLQEILQRLNELSLDLLSSSAEQSEEEGLNQTPSFTSAPPSSSRTCPIHQAGSKAVETCCNHCEMVIPVLNLSSYPCVPTCNAVMHLIRFDHVLCKVLHVKLTNKSNATHKYVAFNISDNLIIKSRMLNKISARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU62</accession>
    <name>A0A0R3WU62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4288</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004080">
        <property type="protein sequence ID" value="VDM24612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU62"/>
    <dbReference type="STRING" id="6205.A0A0R3WU62"/>
    <dbReference type="WBParaSite" id="TTAC_0000430201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000430201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000430201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06892">
        <property type="entry name" value="PX_SNX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000430201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44273" checksum="75936A0F3B52370A" modified="2016-01-20" version="1">MASDFADPSTFLADTVPIGGASVVPHGFNSQGRGVSDAVDNSSDFYLTVEISDALSNKGFVSFTVRTKTNLPEFKQQKMQVNRIHDDFIWLHDQLEDNEAFAGFIVPPAPPRPDFDSSRAKLQRLGKSEGTVTKQDMQKLKAELEAEYLANFKKTVAMHQVFLQRIANHPVLRNDYGFRVFLEYEQELSVRTKNAKEKAAGFLKSVTKTADENLLLPNQREDDPFFREEKSYLVRYYNAVHEAHQSTDAVCRNRRLLGDSILRLELLLQDLATTPPINLKAVEAMLTSKLCNFFSSLYPLQMRVTADEDLKLVDTLAYYSAESAAAKDLLYRRSRALADYASANRALDRARAKQRDIGAADTQQVAAHKRFTEISQMARRGKLSNFSSLVISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUE2</accession>
    <name>A0A0R3WUE2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4367</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004238">
        <property type="protein sequence ID" value="VDM24770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUE2"/>
    <dbReference type="STRING" id="6205.A0A0R3WUE2"/>
    <dbReference type="WBParaSite" id="TTAC_0000438201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000438201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000438201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000438201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="704" mass="77267" checksum="6B9C9AF1E2D2A774" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVC0</accession>
    <name>A0A0R3WVC0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4697</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005119">
        <property type="protein sequence ID" value="VDM25472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVC0"/>
    <dbReference type="WBParaSite" id="TTAC_0000471001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000471001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000471001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000471001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17072" checksum="C9D78B0BB37160D9" modified="2016-01-20" version="1">MSTPLLRRNSLCLASTTSTRVSSQSSASSPLAAQPLSRTPMSSASYVPGRGSLVERKPPHVILPITPTPPPLPPPPPNPQLAPLKPRSRSQQWTSSKAFGIGGLEKLPAVINPLEAGLGLTDGGFKISVGHLKLSLFNVSFSATSYRLTKSSPKVVWVGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVC2</accession>
    <name>A0A0R3WVC2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4696</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005117">
        <property type="protein sequence ID" value="VDM25470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVC2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000471201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000471201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000471201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133020" evidence="3">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM25470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000471201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15175" checksum="A0DD39668D6C1391" modified="2016-01-20" version="1">MGNWMHGFFAFVAVGATNVGSIHVFADPDLVTNRQPSYLRHLFSARRGVKVTSNANGPTSDPVSASECGTMPIIIKMDGYEDLHFLQPIKTIKGELFGEFNFGSTIVLIFEAPAGFQFFVKRAERVRVGQALGHVVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWL6</accession>
    <name>A0A0R3WWL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ICA69 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5142</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006376">
        <property type="protein sequence ID" value="VDM26345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWL6"/>
    <dbReference type="STRING" id="6205.A0A0R3WWL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000515601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000515601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000515601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000515601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8991" checksum="7E82151B29B02A53" modified="2016-01-20" version="1">MYKSWMGKTESKASEPHESVTLSALASRRSGAQTPTTAEAPLADQPSIPMDEFAEEHYSKGYQWQSQNSLVHFSIDDCSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWV4</accession>
    <name>A0A0R3WWV4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5230</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006682">
        <property type="protein sequence ID" value="VDM26529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWV4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWV4"/>
    <dbReference type="WBParaSite" id="TTAC_0000524401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000524401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000524401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000524401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7337" checksum="3E907E90C99A433D" modified="2016-01-20" version="1">MPGPPPPPPPPPPPPAAPPPPMGGGGGGGPAFLADIRKGAVLKKVPESQKNDRSAALVCKYTFPLVFCKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG6</accession>
    <name>A0A0R3WXG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5441</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007523">
        <property type="protein sequence ID" value="VDM27001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000545601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6293304at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="37036" checksum="B5591CE3DC5A0CCD" modified="2016-01-20" version="1">MPRLSLDCTQTTSQRTLTDLPTIVALQICEYLDAADLVNLCTTVPRWKAFLTRRRFIHVMKQHIRQWTWFDKRLCQLLLPHPLNASIENICEAIMYRSALTKSFHRFRNRLALYRWQQLQLQHHHHHHHQHQKQDDDFVNIDVYPIHVRDYLHNGIERMHRAVLRGALPARFPFHRNLHVHRELDHECKSTRIAMGNHFIGGAFTSEADQRQCSQCITYLAKPTWVPDADFTAELEALATHHVINIAFMVDEKEDGLSLWNCLEQCLTCLVTMSADWRVWSIKPCSGEGFINWDSLEDWSCFHVHMATRRWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXJ2</accession>
    <name>A0A0R3WXJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5468</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007652">
        <property type="protein sequence ID" value="VDM27056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXJ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000548201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000548201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000548201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60477at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057954">
        <property type="entry name" value="SET_TTL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25556">
        <property type="entry name" value="SET_TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000548201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17662" checksum="D1DFCEB60CFA25CC" modified="2016-01-20" version="1">MNGIVDRPERPIRIIYPFRVASLLYVPEQLCYSLFWPIKDLHKEDTLYVDWLSVVTEEEKKSLLLIPWEGGDFSDRSSAHTFVLTDEFFTSHKIAETLPDPKATLVSSAATPQLVYTDLELVARMLTSSNYKITTNRDQAGIVWVRKHIRDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXR3</accession>
    <name>A0A0R3WXR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5536</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007884">
        <property type="protein sequence ID" value="VDM27176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000555301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000555301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000555301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000555301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33723" checksum="4D9BBE216649D05D" modified="2016-01-20" version="1">MPRSTRNSNASKKRILRGGNSSERSRNRTISLDNNKPGTPRKSLRSAKASPAPSVASSSASTVSTTTTTVTRSLRKRAPPSPEKETPSPVQVPINDGTGYKRRRVSVPPSPEPSFAPAPVKGINPTGRKRRGPPKEATAKRAKIALQGEPTKFFGGICVGIVLGAFIINQAPDSTTPGSSSSTSASLKRRHQAVGGRVGGVVEEEEEEHSSYSPIASTSATAKKRGAKRSRRAPKKSSAATEMIEPAILKPSTTENEDVKGMKEKKDEQIEKSEESDELAVPSPSKSPVAEVKTSLSKKELLALQRRQLLQHLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXV5</accession>
    <name>A0A0R3WXV5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5580</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008072">
        <property type="protein sequence ID" value="VDM27265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXV5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXV5"/>
    <dbReference type="WBParaSite" id="TTAC_0000559501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000559501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000559501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000559501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13073" checksum="736A2480E0C48B7A" modified="2016-01-20" version="1">MSFTARCLVLLAPLQVLIILFRPLDLHLRIKYYQNLRRQTAREKEWRGPRVSAEQQRRRRRAVKAEASEAAACIKAQAMARAQAAQARAAKKALKAQKAQQRRVIYRWVYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY73</accession>
    <name>A0A0R3WY73_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FACT complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008628">
        <property type="protein sequence ID" value="VDM27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY73"/>
    <dbReference type="STRING" id="6205.A0A0R3WY73"/>
    <dbReference type="WBParaSite" id="TTAC_0000571301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000571301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000571301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000571301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11406" checksum="4ACB360E3F1EF99C" modified="2016-01-20" version="1">DSVEEESNDDGESDDVDEHESDEDKVEEVNASPSALDSGESEADEMDATAGNDSEGEAIDASLVEVLKTRRACEKALKSPGAKRNWRTTVGTERVGTVPKVVIFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ07</accession>
    <name>A0A0R3WZ07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010055">
        <property type="protein sequence ID" value="VDM28113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ07"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ07"/>
    <dbReference type="WBParaSite" id="TTAC_0000599701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000599701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000599701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000599701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35935" checksum="D72BC04E9A22E1B6" modified="2016-01-20" version="1">MFDQAYPTRSISQLTIHEFNPVVDSGVTVKAVARTVDEELETTCELRAPEEREKPKRFIAEFTHSLQPHLEVQETHKVILECSVQAPEGPVEFKWYRSGIEISPEVFREITIERSASRSILTIERVEKKHEGPVTVEVTYPQGEKLVSTCDLHVVPQQPLTEVVLQPEEKTPASVPLRLVQPLQPRVEPVAGEDVVLTASVEAVPQAEITWTISSPETAKRSEIVPLVDQAHPTRTTSQLTVHDFTPQVDESVVVQAIARTPTEELVTSYELHERRPTISEVVIETGPMPTAPADRPQEVVSRVPLRFVQPLQPTVAPSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ27</accession>
    <name>A0A0R3WZ27_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="15">PPIase</shortName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS6003</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="EMBL" id="UYWX01010173">
        <property type="protein sequence ID" value="VDM28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ27"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ27"/>
    <dbReference type="WBParaSite" id="TTAC_0000601701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000601701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000601701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000017">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000601701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20105" checksum="46C83A72A2141AD2" modified="2016-01-20" version="1">MAVPAPMVAERMNNPKNPVVFFDISIGGQDIGRIQLELFADVTPKTAENFRQLCTGEYRKDGVPTGYKGCTFHRIIKDFMVQGGDFVNGDGTGSCSIYGGSKFSDENFIMKHSSPGMLSMANSGKDTNGCQFFITCAPCDFLDGKHVVFGQVVDGMLVLKKIENVPTGPHNRPKVPVVITQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ70</accession>
    <name>A0A0R3WZ70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6044</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01010454">
        <property type="protein sequence ID" value="VDM28298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ70"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ70"/>
    <dbReference type="WBParaSite" id="TTAC_0000606001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000606001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000606001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM28298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000606001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13571" checksum="4B18D2EBBFB4FBCF" modified="2016-01-20" version="1">MNAAKAQFKRRSTANQVEIRIPVPSDVDSPRFKTTVGTCKYIPEENLVMWSIKSFPGGKEYIMRASFGLPSVEGDTTAESRPPISVRFEIPYFTVSGLQVRLFNPVYSPIVVLQVFTKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZF2</accession>
    <name>A0A0R3WZF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6156</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZF2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZF2"/>
    <dbReference type="WBParaSite" id="TTAC_0000617101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000617101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000617101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000617101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29661" checksum="A5FEBC3EEE710566" modified="2016-01-20" version="1">MTTIHWNRSSGRGALRSRSTAVMDIASLSSFLASSDSEYDRASPRPSTAAITNGANIASTFVEKTKSSMEDGERLALQLVEAQKLTPEQVLEIRRSFNYFDKNGDGSISLEELTAAFGTIGHAHDHTLIGNLFKEADVNGDGTIDYKEFVSLMAMSFQSQNQAGNSSSSRNDMYREAFTRFDVNNDGVIDSNDLKELMMNIGKQLNDKEISEMILEADKNGDGVVDYDGKLSFTLQPHLLLHLRRLLPCPLIWLQILFKEPSKERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZH6</accession>
    <name>A0A0R3WZH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000619701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000619701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000619701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248820at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000619701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57014" checksum="CBE66EE5EA1E8CE5" modified="2016-01-20" version="1">MPRTRPRSLNLRIPTEETYNDTLYPTYIPRASSRSRLCNKCSNGFYPVPTGALMPSPAFLPVQCMIPMVYAPAPPPIAAPMPIPPVVYKEPLQLPELPYPPAESDETDSGEMEDMRTTTEETFSTLQRNTSRRNDFVATNLIRDFEETNWISINDNSRNVQDWTIKRNHWFQRSVELPPGVITKLRCEKLPMDVTNYSNLRKNNMQRLRITGRVRQWSPTMRAITEEDFSEELFLPQGTDLSTISYKLQTKNIQQYNESQFNKVLRHHSTSYDEDIRGQPFTENTVVITGRVNRISKQEVPSTDQTWSKEYKHTVKGTIDLSPEGHIMNPVITSYSEMPDALADLASTPDQDTSCTVADGKWQIRIRLDDRVDRDSIEMEANPREETVKLVFARHSQNNTNGLANDNYQPKMATTTTVFALPANKFDITGISKRVQGQDLVLSIPFSKGFQLSDLNIASLPLTLLFELDHRNRLVESRGYSSPCIHKFYNSRLISIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0D3</accession>
    <name>A0A0R3X0D3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6567</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020308">
        <property type="protein sequence ID" value="VDM30794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0D3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0D3"/>
    <dbReference type="WBParaSite" id="TTAC_0000658201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000658201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000658201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="198"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000658201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42179" checksum="6008583EC5B7544F" modified="2016-01-20" version="1">MEPSELRSNDKGDICPFCRPKEFHDFENIEDAVFAWLDDNTNTLRNYIYSHASQSIVEDLLRASAFKKSKSLYPFQSNFARMNSFVAPQSKNKEMPIRKISSSEFEPLAFHPILATGHDGCQSFLASVSIGGGLPKNDFSGQMSSKTVSTETSGLPSNISSDQEEKPEGLKALADTFKEFYSNDVMKELVLDIWSDSDLSSLCFKILRNACLLLNADRASLFIVEVNSSTGDRFLVSKLFDVTAKCTLVEALHKSEAKTVSLPFGVGIVGWVAQTGEADPRFNREVDLKTGFHTRCLICMPIKDGEGNVLAVAQVMNKKQQKPVDEHDTSLVFSTRDVNLFEAYTSFCGIGLHHAQILFRSQLETRRSQASLLSPFHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0I9</accession>
    <name>A0A0R3X0I9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6634</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0I9"/>
    <dbReference type="STRING" id="6205.A0A0R3X0I9"/>
    <dbReference type="WBParaSite" id="TTAC_0000664901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000664901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000664901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="237"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000664901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40050" checksum="F9631D4A635F2E8D" modified="2016-01-20" version="1">MAAESSTNVPPTSTFTEEDEKEIFSHPFFARSAEDMEGNPAYEALRALKYESDDPNANAESFREEGNYYVKQKNYEKAITAYTGGILAKPTDKKILAVLYTNRGIAQAMIKNHGSCVKDCNWAIKQDPTHLKAYLQAAKSLMVLSKPAEAVKVCEAGLKVVANNKTLLELKAKATDLQAAMTIKDEDKQSAVKESHCKLSGAFKQLAARGIVIDFEQPPVGLPDHAAVEISFDHMNLIHWPVLFMYPEFSQTDFVQDVAEYLTIRECLKHVLNPSEPPPWDRERAYTTSEKELEVYFEDTKFAKQMVKVPISRTITELTRCPGFYVRRDLVIVLFVVSKLSENFYKMWIENLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N4</accession>
    <name>A0A0R3X0N4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6693</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0N4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0N4"/>
    <dbReference type="WBParaSite" id="TTAC_0000670801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000670801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000670801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21495at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000670801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12498" checksum="67262A56CB795905" modified="2016-01-20" version="1">MSTSLSPERPKAQPNRHNSNISGSSINQAAATRGARGGAGSGAGALLRAWLAGHQERPYPTRAEKAALAFATHLSLAQISTWFANARRRLRKEERLAKLEVGRGKKTTATINTAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X159</accession>
    <name>A0A0R3X159_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6895</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020329">
        <property type="protein sequence ID" value="VDM31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X159"/>
    <dbReference type="WBParaSite" id="TTAC_0000691001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000691001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12046" checksum="7287EFB050FD1D3D" modified="2016-01-20" version="1">MAMEEISLTAAFKWVGDRISGAWSDRGGWQEDKQPFSSHHPDYSTIASCFTLKGQVEVGWRRRKTIVIENMRAAEGLGEDERVGYEDRSTNEGVDEDGMYGREQGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1D7</accession>
    <name>A0A0R3X1D7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6996</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1D7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1D7"/>
    <dbReference type="WBParaSite" id="TTAC_0000701101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="197"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="63991" checksum="512AEFA2A3B49087" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1X0</accession>
    <name>A0A0R3X1X0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7223</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020354">
        <property type="protein sequence ID" value="VDM31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1X0"/>
    <dbReference type="STRING" id="6205.A0A0R3X1X0"/>
    <dbReference type="WBParaSite" id="TTAC_0000723801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000723801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000723801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="450"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000723801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59263" checksum="1BD8200F8AAC0BE1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2G3</accession>
    <name>A0A0R3X2G3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020375">
        <property type="protein sequence ID" value="VDM31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2G3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2G3"/>
    <dbReference type="WBParaSite" id="TTAC_0000747701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000747701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000747701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000747701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="22918" checksum="F7414C7329BD3ED9" modified="2016-01-20" version="1">MPPCPPTLQTPYRACSAMERNCHLQKTLPEGCHEVFAFTDDFFNSADLTIPLPMLKCGGAPLVDFGDACKETEMKASSFLPSRAADTASSSTHTTVAVVQFTVTATAFISIDFATHVLILQSDGVLSQTQFETDHQYHPSPSSAEVHQQAAKGKSSQQFYASQTHRQSPLTPVGQQTVSKSQQEEGSTNMGTESVSTGGCYSGDAEVVSGGSGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2U6</accession>
    <name>A0A0R3X2U6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">rRNA-processing protein EBP2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7619</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2U6"/>
    <dbReference type="STRING" id="6205.A0A0R3X2U6"/>
    <dbReference type="WBParaSite" id="TTAC_0000763401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000763401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000763401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000763401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35999" checksum="AA1F54112E1F0688" modified="2016-01-20" version="1">MSDTESDSDLQELLCAPGVYKEIKFPKSSINNKPLLKNVLRQISKSFPWIERLDIVTEPALPPKDTDLENDFNKIDPNDDFKREALFYRVAQAAVLKAIPRLHELGIPTKRPSDYFAEMIKSDAHMAKVVREQIVVNKKRLEMRERARQLREQRKFGKQQQKEILEARRLEKKKHMEALKAAKKRPGGKEQAQVLEELLQSGSKQSKGKHSHDGGGKNQDRKYFRPSEYAKRRKINYRRAYKNQKYGFGGQKKRSKRNDAQSICTTSNDGVSVLTHTASASRIKLLNRRMQKTRRLNAQRQRKRMSATKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Y6</accession>
    <name>A0A0R3X2Y6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7665</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01020392">
        <property type="protein sequence ID" value="VDM32085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Y6"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Y6"/>
    <dbReference type="WBParaSite" id="TTAC_0000768001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000768001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000768001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="529"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000768001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="737" mass="83312" checksum="88D3C29507A1A86F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3M1</accession>
    <name>A0A0R3X3M1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7940</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020423">
        <property type="protein sequence ID" value="VDM32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3M1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3M1"/>
    <dbReference type="WBParaSite" id="TTAC_0000795501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000795501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000795501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF378">
        <property type="entry name" value="FI03225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133224" evidence="6">
        <location>
            <begin position="20"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000795501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="660" mass="73280" checksum="3C920011A31703DC" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3W0</accession>
    <name>A0A0R3X3W0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8043</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020435">
        <property type="protein sequence ID" value="VDM32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3W0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3W0"/>
    <dbReference type="WBParaSite" id="TTAC_0000805801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000805801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000805801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276296at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000805801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20568" checksum="37F9451872C0C4E7" modified="2016-01-20" version="1">MLTKSTELPTLEELEVPEIKMTAVPLLAAALYMGKYCDQQSKEFMLCSQENHDPRKCLKEGKDVTACGLEFLRLLKKNCADVFAPYYQCIWKHGGPYFTIQKCRKLQYPLDNCIKEKMGLERPELGYFNRVRLVDTKRPKPVPKLAPMPERIPDMPSFDSMPEPEKLEARKHVNEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3X6</accession>
    <name>A0A0R3X3X6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAP-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020439">
        <property type="protein sequence ID" value="VDM32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3X6"/>
    <dbReference type="WBParaSite" id="TTAC_0000807801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000807801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000807801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253710at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000807801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32155" checksum="7B119187822ACBA1" modified="2016-01-20" version="1">MANSGSRYDSGGVTTIATHKHRLISLLANQTARLGGHNQSQFGNRWLTQDLDFSPAYPQTCYVQALSAMSRRDEACCEKAAENAFLLNWTRDRLRRTTQKLRRTMITTADWPPPRVIFNSEVSTTHDRDEDKTTAWFLPCCFQGCRNRSPEVEDSKGTRLSQMLMGTYKKENSVKCKNLMLRTGPDGSLICPDHVDVSMLIEGFREFERRFQYGTLMPFANVLPSINPARHEVSQKAKDGEINEQISGSSDLKDEGKNKKGKTDRVFQESYQDVLVVQDICEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X516</accession>
    <name>A0A0R3X516_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8520</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020522">
        <property type="protein sequence ID" value="VDM33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X516"/>
    <dbReference type="STRING" id="6205.A0A0R3X516"/>
    <dbReference type="WBParaSite" id="TTAC_0000853501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000853501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000853501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="323"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="394"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000853501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50351" checksum="FFBDCFC1503B20DD" modified="2016-01-20" version="1">MADDDDWGITPDYKNVMTERERRFGSQAVPGRVGHVDMNALIQGALESDAESKKNAIPKASYGYGGKFGVEKDRMDKSAVGTDYQSEVSKHSSQQDYSKGFGGRYGIQTDRQDKTALGYDHHEELSKHSSQKDYALGFGGKYGIQKDRVDASSFGYRDAPEPSVPHQSQQRPEVSSGQNRASELRARFEKLALDQNKSVERPPRPQVGRLKPNIFSKPVPAEEPKPAPKPTIPIPKFEPQMPQTFEEKKVEPQEKKADEEKHERVEEPWEPEPIPHRVKPSSPEPEPTPEAEAQMEKEEQEYKDLKPALQPSQPTESSVQARTSNITAVAAFDFVGSQSDELSFHAGDTIVNIDKFDESWWFGYIGTRSGIFPANHVEEIKSGTDATKVGSNPPSSITAMALYDFVASQSDELSFKAGDEICDIDKFDESWWSGRIGDRFGIFPAIYVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5H7</accession>
    <name>A0A0R3X5H7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8705</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020566">
        <property type="protein sequence ID" value="VDM33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5H7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5H7"/>
    <dbReference type="WBParaSite" id="TTAC_0000872001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000872001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000872001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000872001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23859" checksum="E8AC7E5EBE6AEA0A" modified="2016-01-20" version="1">MTAFTHLSAAPTRVQRPRGKAISPTEIRLTWRKPLHPNGVLKPYQASCVDIERRGTPQIVTTKDSRTTSAVVGNLIPDTKYQCSVVASTVPVVGKDPAQFQRRSAYSNPISTKAQTPSRVRRPTGKAISSTEIKVKWTKPKHPNGILKPYKVTCFTTSHGGTANSVTTKDNETTSTVVANLIPDTEYQCMVVASTTAAVGQDPAKCESRSALSALIRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5L3</accession>
    <name>A0A0R3X5L3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8751</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020576">
        <property type="protein sequence ID" value="VDM33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5L3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5L3"/>
    <dbReference type="WBParaSite" id="TTAC_0000876601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000876601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000876601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000876601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8483" checksum="F0E61FC79509020C" modified="2016-01-20" version="1">MPVPSSGSFGQPGQPSCFQRMKMGFLMGFCVGMATGAIFGGFSCLRYGLRGRELIQTVGKGMIQGGGTFGMFMAIGTAIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U1</accession>
    <name>A0A0R3X5U1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IPPc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8840</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020603">
        <property type="protein sequence ID" value="VDM33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U1"/>
    <dbReference type="STRING" id="6205.A0A0R3X5U1"/>
    <dbReference type="WBParaSite" id="TTAC_0000885501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000885501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000885501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133202" evidence="2">
        <location>
            <begin position="21"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000885501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65487" checksum="9FDF94EDE2453EB0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6D4</accession>
    <name>A0A0R3X6D4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9047</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020665">
        <property type="protein sequence ID" value="VDM33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6D4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6D4"/>
    <dbReference type="WBParaSite" id="TTAC_0000906201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000906201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000906201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="42"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000906201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28106" checksum="F8F457D25C23353B" modified="2016-01-20" version="1">GISIHGLEPYATYSIVVEGRHNGAAVFNLERTFRTWPTAPISVSPPTGRAKSTSEIELHWFAPTQLNGILKPYLVVCFDLANPSFQQSTITKDNASTSVIVGNLRPGIEYRCSVVTRKHPGLGQDSKQCSRASDFSAPIRTMALAPSRVSRPRGMATSPTEIQLTWSKPKHPNGILKPYRVVCRDVAQFYAPSMAITKDNETTSVIVKNLHPDTTYQCLVVASTIAAVGQDPLECERLSNPSNLIRTKSQSALLASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8H1</accession>
    <name>A0A0R3X8H1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9831</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021085">
        <property type="protein sequence ID" value="VDM34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8H1"/>
    <dbReference type="WBParaSite" id="TTAC_0000984601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000984601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000984601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000984601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17159" checksum="D52BD14C512ACE95" modified="2016-01-20" version="1">MMGELQLLKAVGKALNDVREDRMCKNGEVCVVFSFLFSWASYDRLQYLPLYTCLSVALLVILTRAPHQLTLTAAGAVPPDFACHMFHIGVENSKVVVDMSSLFSFVYLTSQSLIASFPLPDYVFEATHRCIWWLRVVRRVAFNGAKKAGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J8</accession>
    <name>A0A0R3X8J8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9858</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GrpE family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021113">
        <property type="protein sequence ID" value="VDM34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8J8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8J8"/>
    <dbReference type="WBParaSite" id="TTAC_0000987301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000987301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000987301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000987301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48169" checksum="A0079D07810B9B49" modified="2016-01-20" version="1">MGVAGKAAGWEFQAPRKDFWHKITLERGKHHTVGKLIHKTSGVVLSASTQESAISKRLYSTVDVSAAENIGRILAHRCHCMGITTALFDVTETPLTSTRNKAFHDALLECGLELEEPSISRPESYGIDYDSLSLEEKRSLYPSLIEELRTTPDWGQQTYPYSLRPLAGRRKLKMEYQVLSKVRQGYIWDRFYARLVKPEHLAAWQVEQQKIQEETLGRPPPSLDSLEEPAEPFVPEKWSTEAADNSQKTSEENVTTPLPVNKEMEDLLAKSAKLLQERNEFEDKYKRALAEAENVRKRMLRQVEDAKFFGIQSFCKDLLEVADVLGKATESAPEDQLKDGVNPHFRHLFEGLKMTDAQLLKVFSKHNLHKIAPAIGDAFNPNIHEAMFTIPVSGENKPNTIAVIQKVGYSLHDRTLRPAYVGVFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8K7</accession>
    <name>A0A0R3X8K7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9867</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021119">
        <property type="protein sequence ID" value="VDM34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8K7"/>
    <dbReference type="STRING" id="6205.A0A0R3X8K7"/>
    <dbReference type="WBParaSite" id="TTAC_0000988201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000988201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000988201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039508">
        <property type="entry name" value="KASH5_EF-hand-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14658">
        <property type="entry name" value="EF-hand_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000988201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17844" checksum="D5BDE038446571B5" modified="2016-01-20" version="1">MPPKLATYVTEERLVEYQEAFDTFDPDGKGKIPCEHVLVCLRKVGLMPADCELEDLLRSVDSENDVFAEGINYDQFCQIASKKERDVYNERDIVNAFALFDSTSKGYLTTEELTQILCTRGDKLSEGEMAALIKTAGANTNGRIQYEEFVHRMMLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8N0</accession>
    <name>A0A0R3X8N0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein regulatory complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9890</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DRC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021135">
        <property type="protein sequence ID" value="VDM34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8N0"/>
    <dbReference type="STRING" id="6205.A0A0R3X8N0"/>
    <dbReference type="WBParaSite" id="TTAC_0000990501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000990501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000990501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27917at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF12">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000990501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="575" mass="66840" checksum="604A55787489E67F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8N4</accession>
    <name>A0A0R3X8N4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9894</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021138">
        <property type="protein sequence ID" value="VDM34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8N4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8N4"/>
    <dbReference type="WBParaSite" id="TTAC_0000990901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000990901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000990901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033291at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000990901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48037" checksum="2AF964DCB1F55A90" modified="2016-01-20" version="1">MKVKERDEEATSTPLLASQHLIPAIWEAAFCYYVAQYISPGWLRSTVSLPPRVQVIERRRTSRVRSADGNSNSSTTDSPSDVFNSPLQRPRQLHPLNPTIADANEDYDPDFENLPMLSTLRDKVAVEAEAVLNQAVQMSLKVTSRGVTKLCRLFGGCLSSDTAQQIRESQAALFDKLDWTGDAITQALTTRNQHSELPSGGALTIRLTQAQPYNGRDTGRGRRPTAPTKLEMDGGDSSRDSSSRRNDSSVIDSEEEGEEAEEEEEEEEEEATSPSGFSSLHCDDEVHSTPGEEEDTGFGSSATGGTTKSAQQRLESVFFCRFLVGLSKRIIEEFVENREQTFAPPFNSITTYLNTSDGTFRGSLVINWETGTQVLNLTKAISKWMHNAGVQNHKEAMQLLYDFSRLMATPRQELLNTRLSGKKPSQQFVKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8V3</accession>
    <name>A0A0R3X8V3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9963</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021194">
        <property type="protein sequence ID" value="VDM34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000997801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000997801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000997801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000997801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11452" checksum="2B4460201F02660E" modified="2016-01-20" version="1">MNSGRRVFCAPSGSSPADMPARRLQRSHHQSYQPVYVIQLGAAPAPAESMVVDQVSEARPISHPSVPTIAPKLDAPATSSPGPAKGKRPLLPLDDREMRRRVSGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Z9</accession>
    <name>A0A0R3X8Z9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10009</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021237">
        <property type="protein sequence ID" value="VDM34989.1"/>
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        <property type="protein sequence ID" value="TTAC_0001002401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001002401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001002401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16547" checksum="05C2A2A39F2CE7EA" modified="2016-01-20" version="1">MGVKDGQFWGRISPSMRGEVWFVSFEVDDETVQFCLGGGRRGLKKEIGRECHLRQRMSHLVMVEVVKALAADTTSCSTAKGMPTKYAIRWQKYLQRRSPSASQPKAVLGGSSPCVQAWRDDGLRITSANSRPTDSVALTEVSSCATSQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9E5</accession>
    <name>A0A0R3X9E5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EXS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10155</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021363">
        <property type="protein sequence ID" value="VDM35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0001017001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001017001"/>
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    <dbReference type="OrthoDB" id="9970435at2759"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35135.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001017001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="68023" checksum="6D2541E2FDF65E7E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9G4</accession>
    <name>A0A0R3X9G4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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    <reference evidence="2 3" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0001018901"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001018901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15903" checksum="54F8C804EA747501" modified="2016-01-20" version="1">MWMLRRLRESGQLLGLHWRCGISKPLHSRKRNNSAQTCDEKPERSAKAQAKKTDKQHKGDQKQDEPDSRSLFDTKYLAEVYQDFYRELANAYAGFINGFKKEPDDHVRSVSRFRPIRFDPSTNVLKQGPGNALEHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H7</accession>
    <name>A0A0R3X9H7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10187</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3X9H7"/>
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        <property type="gene ID" value="TTAC_0001020201"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
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        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46783" checksum="7C5C9D7AF5F849EC" modified="2016-01-20" version="1">MDGVYGNRIYFARLICGKILTPLICTTGIVVNIINIIVLTRAWMKSSTNVYLTAVAASDLIYLTHSLLFSLQIYQTFYSMWIYMQAVPIIHGTANLFSNITTWLTVSFTIERFINISFPIFGHRVCTRGKAKRIVCIVCVVSFIVTFPDFLQRKVTPPMDANGTIISGGRYIVEDSEYQRVLTAFGYAFINQISFVILPFLLLTVFNILLIRKGLKAKQKRRCMSKEYQDRHPKVQYASKGVTIEKSCLNASVAAAQIRSNSTRRVLFSEQQRITVMLISIVVAFLILQIPSTVLNIISNLLTSEEIVADANFHSLIIVFSNISNVFLFTNATMNFVFYSLFSIKFRTTCKSLFGRRCMATGGKAGVHPFGHQESRKNGLTVVEMEARRVGIARALQRLSISCEATVDVTSQDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9I4</accession>
    <name>A0A0R3X9I4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10194</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021414">
        <property type="protein sequence ID" value="VDM35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9I4"/>
    <dbReference type="STRING" id="6205.A0A0R3X9I4"/>
    <dbReference type="WBParaSite" id="TTAC_0001020901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282999at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="229"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56813" checksum="C3903A229B72B393" modified="2016-01-20" version="1">MRGSLVGGDHWHVRLTTGRRDAKFRAEYTSPCTANVFLTVQGTKNTVSDLLLSMYQSGVTNGVTSPSTKASKNRTTRPLFSPGQTDEFVVNLGDIGDIVKVRLSHDNTGDYPELLISHMRMTRLPATHASGKSGRPRDGIASSVSSHSLADPNFADLTFFFSSWLSKNIGDGQVIREVASRGSLSLVLQEQQRVRQEALKRPQRNVSVTPSIEASKGVVDEMLQLPGKHFYSLVVRFIPNLWNAGTVGEVMVFLVGQFGDSGPRHLWNWQSAKRRPFQRDQVDDFKIQCVTLGQLSSIKVWLESPLKKTPETWCLEWIQVIEEDASTTSISPSTSVIVRQPPVLFYGDQWLYSEPMANDLQMVPIVLPVDRIFGPNGESDYAFPEKIAKLFALASKPWLHLMVAEDGCLCVGGRLNYQFATNPQFTSIIKSTSESSGPMGFLIRPHLGGFVQLESVLSRDSVEQLSRFRVSPSDGSVCIDETANHEETLLMPFVKVFYATAYLHSQLLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA53</accession>
    <name>A0A0R3XA53_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10413</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021670">
        <property type="protein sequence ID" value="VDM35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA53"/>
    <dbReference type="STRING" id="6205.A0A0R3XA53"/>
    <dbReference type="WBParaSite" id="TTAC_0001043001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001043001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001043001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01766">
        <property type="entry name" value="Ubl_UFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001043001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9882" checksum="13476BCEF984F047" modified="2016-01-20" version="1">MSGWSKVRFQITLTSDPNLPFKMYVLDVPDSTPFTAVLKFVAEEFKVPPATSAIITDDGIGINPNQNAGEVFLKHGGNLRLIPRDRVGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA71</accession>
    <name>A0A0R3XA71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ZnMc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10431</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021692">
        <property type="protein sequence ID" value="VDM35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA71"/>
    <dbReference type="STRING" id="6205.A0A0R3XA71"/>
    <dbReference type="WBParaSite" id="TTAC_0001044801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001044801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001044801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="12">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="12">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="12">
        <location>
            <begin position="318"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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            <dbReference type="EMBL" id="VDM35411.1"/>
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        <source>
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    <sequence length="368" mass="41846" checksum="E7956D3521FB0D72" modified="2016-01-20" version="1">MCCWSIVLAFWGNQYDGNFFDGCVIGGVLAHAFYPMPEPVYSLAGDAHFDDEEEWWDGPHKEYRDLLSVATHELGHSMGLGHSSVHTSVMFPYYLSKWKRVELDQDDINGMQKIYGAPKPGKVLPEIPDLPDIPSIPETTTVKPDTNKHIDYCNTSVDAIIEVRGLELYIFKGEYQWRVTWSKTVSNWISYQLRDGPTKIAYYWNVLPPDVDFIDAAVERPDSLIYIFRGNKFWLLADNKRLAGGCPRSGLPLTKLGLPEDLRKVDAVFKWDVNQAFYIFAGDEYWLLDVKASPSPFGRVAPSPDYPRRIKDTWRGIPTPITTAYTTLNGETLFFDGPQYYVFDNIAMQARKGYPKPAKLGIIGCQDT</sequence>
</entry>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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                <consortium name="WormBaseParasite"/>
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                <consortium name="Pathogen Informatics"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="396"/>
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        <location>
            <begin position="424"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="VDM35468.1"/>
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            <dbReference type="Proteomes" id="UP000274429"/>
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    <sequence length="611" mass="68862" checksum="A5DFEEEEE72E9D3F" modified="2016-01-20" version="1"> </sequence>
</entry>
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    <accession>A0A0R3XAP2</accession>
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        <name evidence="2" type="ORF">TTAC_LOCUS10602</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
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            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
            <dbReference type="EMBL" id="VDM35582.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0001061901-mRNA-1"/>
        </source>
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    <sequence length="164" mass="18205" checksum="69CDE51E5DB4D597" modified="2016-01-20" version="1">MILYLCTVISASDLGGVMVSGLFRPFVEVYLFGPLLADRKRRFTTKSKSGTISPLFNETFVYYLSSRSDPEWYELQFVVKDYCFGRSDRLVASSLLTLSQALDLGGSAPVRLPLTRRQAQSEAGWTVLRILSQRLATDEVAREFVRVKTECCSAAGTTAVAQAE</sequence>
</entry>
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    <accession>A0A0R3XAX0</accession>
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        <submittedName>
            <fullName evidence="5">LZ_Tnp_IS66 domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10680</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022036">
        <property type="protein sequence ID" value="VDM35660.1"/>
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    <dbReference type="WBParaSite" id="TTAC_0001069701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001069701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001069701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288277at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001069701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11768" checksum="B643BB80A1D372A0" modified="2016-01-20" version="1">MPKTGSSSPARNSYVLGASEVALETVAEQLRHWRSVALVARAEAVCERAKSRALSAELARARCDLNMAETELGLLRKRLSLLESALAASRSGSFGTAGDVASPSSVPRDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBV3</accession>
    <name>A0A0R3XBV3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022739">
        <property type="protein sequence ID" value="VDM35993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBV3"/>
    <dbReference type="WBParaSite" id="TTAC_0001103001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001103001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001103001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001103001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7680" checksum="E76FF32BC687A130" modified="2016-01-20" version="1">MEGMRHTVLSTQIVQSIETDGEGDESITETRAVGQPSSHPLSTMLRCCCIACGERVLAKAELGGSRVGGLGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBV9</accession>
    <name>A0A0R3XBV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11019</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022749">
        <property type="protein sequence ID" value="VDM35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBV9"/>
    <dbReference type="STRING" id="6205.A0A0R3XBV9"/>
    <dbReference type="WBParaSite" id="TTAC_0001103601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001103601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001103601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001103601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="491" mass="54567" checksum="4B08169D9F26A796" modified="2016-01-20" version="1">MSIHYGHKDVLEYFETPEGTYKLKSVLSPKCLPGIPPSGRMSSGVGYGLFAVYFPLQMYDSLAPGKQTFKTSTPICHDFGVSSLLLVGFFTGEIHMIDPFHKELCKVFNEEKYIERSPVTCVRWVPYSTNQFLVAHASGHMYLYNEELSCCPTPPVYQLFKKGSSYVVYTCKTKSTCNPLYNWALTNILSDSVQSKILDDFDASTAPLSSINQFSFSTCGKYLAVVTEDGYLRVFDYHRMQLYGFMRSYFGGLTCVDWSPDGKYVVVGGQDDLITIWSFSAQAVICRGQGHKSWTSVVRFDPFVYPPLCNGTAVLHDLATSSEQLTPNGDPRQHHFSPSIDSDTAFRTYRLGSVGQDTFLCLWELTEDIIRQGLRFSSHFHQFTVRGRQNLEGLSLSPISNFVSAVTEDPVDGSEKIRCIPRSSCGGGAKRKPFLSSFRSPLPLASRHSEQSDASGKSSVLSDNGCHSVLGDKRPAEGINGNNSSTILCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBW1</accession>
    <name>A0A0R3XBW1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS11021</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat EBI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022751">
        <property type="protein sequence ID" value="VDM36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBW1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBW1"/>
    <dbReference type="WBParaSite" id="TTAC_0001103801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001103801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001103801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133345" evidence="8">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001103801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22480" checksum="0183986F9EC9A2E0" modified="2016-01-20" version="1">MRLHYAVPLALSVFIQFCGYRASFDSTVRLWDVTTGTCRQTLQRHTEPVYSVAFSPDGRYLATGSFDQCVHIWNVDTGEPINTYRGTGGIFEVCWNSRGDKVGASASDGSVGGCTGSTAIEAVWCVHPPTSRLPVSTAYVCAVNEFDPPNQPPTCSLLPSFHHLSNAAATFKSPTTAITTSVYLSIFTHVPALFPTFFFVFFKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC17</accession>
    <name>A0A0R3XC17_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysosomal Pro-X carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11077</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022882">
        <property type="protein sequence ID" value="VDM36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC17"/>
    <dbReference type="STRING" id="6205.A0A0R3XC17"/>
    <dbReference type="WBParaSite" id="TTAC_0001109401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001109401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001109401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF107">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133301" evidence="6">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001109401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39279" checksum="D8A71C27F16F43B3" modified="2016-01-20" version="1">MVIVFFFLLLIVPCQNGSPTWPPKVGTYDQVVSHFDFHFHPLTFKQRFVYEDRWYKPGFPIFFYCGNEGNIMEFWNNTGFVFDIAPMFNALVVFGEHRYYGESTPFFNSFVQPYIGFLSIEEAMADFADLIAELKIEFNATSSPVIAFGGSYGGMLAAYMRLRYPHIITGAIAASAPLKWVSGEENLHPFFESIKEIYSDTNESCVLVIQAAYSEILKRSQDGRSGLKNITMELNLCNTLETEQDLDWMLRWSRNAFVLMSMMNYPYASYHLPANPVNVSCNKAIEFGTRSPLTGLREAVGVFYDRSSESCFDYKSQYIDCADVTGCGSGNDSVAWDFQVPVMANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCL0</accession>
    <name>A0A0R3XCL0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023444">
        <property type="protein sequence ID" value="VDM36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCL0"/>
    <dbReference type="WBParaSite" id="TTAC_0001128701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001128701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001128701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001128701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10505" checksum="44B879992D5978F0" modified="2016-01-20" version="1">MLSSVLRTEVLEVEPAAAAVVRRWRRPVVNRVAVPTGRGCPVGGSLEVPGRMASDVCRSSRLSSTPFTGTGMARGEVDYEGLRFIPSDDVSDTEKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCW8</accession>
    <name>A0A0R3XCW8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11378</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023844">
        <property type="protein sequence ID" value="VDM36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCW8"/>
    <dbReference type="STRING" id="6205.A0A0R3XCW8"/>
    <dbReference type="WBParaSite" id="TTAC_0001139501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001139501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001139501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155648at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001139501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25851" checksum="9294C7F5570F8DC3" modified="2016-01-20" version="1">MAFPQHFRWSRVGSRSIQLSWDDHKISGLNLNFIHLVVLADRKHLRDVAMHQLFWLIFAFSALWSGVSGDSDTTLTTLEVTKVTEPTESTKETEVTEGTTGKPLPQHFRWSRIGSRSIQLGWDDHTINGATLHFIYLIVQKIGATTPHFSEQVEFTDGSVTVDGLQPDTVYIVRLSAYAGTEEHLDIISTIKTLKDGEKDITNGSKSSLTYSFAVNFVTTAALLICMPVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD91</accession>
    <name>A0A0R3XD91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024539">
        <property type="protein sequence ID" value="VDM36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD91"/>
    <dbReference type="WBParaSite" id="TTAC_0001151801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001151801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001151801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001151801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8901" checksum="D082E9C43291F537" modified="2016-01-20" version="1">MVVTGWRKRRHLPLSFPCMRCYKMMPVAAAAIVGRRLWLVCHGRADVAVIEVVVVVTMCWWALLVEVDGGAAYVRDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDC0</accession>
    <name>A0A0R3XDC0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11530</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024699">
        <property type="protein sequence ID" value="VDM36860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDC0"/>
    <dbReference type="WBParaSite" id="TTAC_0001154701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001154701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001154701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674273at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001154701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19911" checksum="8D76B7054F9FAAA3" modified="2016-01-20" version="1">MCACAVFALLELVVKIIGVAALISFASCQLPTNLQRAQMLEAHLRVREDVWPPASNMLLMEYSLEMEQLAAQWASRCEFEHPNSKVFPQYHWVGQNLAIFGGFTPTFTEAVCGYNAERKFYHYFNNSCTGVCGHYTQVRRTAHIYATHVAKHLHGVEQYMCACLMKSAKWRDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDL0</accession>
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        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TTAC_LOCUS11620</name>
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    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0001163701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001163701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001163701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001163701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10468" checksum="2C3236EE2BE2C4E0" modified="2016-01-20" version="1">MGELQSLCRDTLRAWLPKCHLMHIECGSVGKVSVEAGVATTSPSSSSLALQEMPLHQLRWRDLCCTTRHSNEHNSQHADTWSSMSAGQYGASALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD74</accession>
    <name>A0A158RD74_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FSA_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS19</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RD74"/>
    <dbReference type="WBParaSite" id="TTAC_0000001801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000001801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000001801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051416at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="2">
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            <begin position="4790"/>
            <end position="5611"/>
        </location>
    </feature>
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            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2659"/>
            <end position="2717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2862"/>
            <end position="2881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3343"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3462"/>
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        </location>
    </feature>
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        <location>
            <begin position="3572"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3814"/>
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        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="4037"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="5402"/>
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            <begin position="1181"/>
            <end position="1191"/>
        </location>
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            <begin position="1192"/>
            <end position="1202"/>
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            <begin position="1219"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="4676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="4770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM15574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000001801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="5637" mass="622985" checksum="1196C1651099C720" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDC2</accession>
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        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS329</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000032801"/>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="951" mass="106252" checksum="6DEED6C08BCCF116" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">TTAC_LOCUS720</name>
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    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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            <taxon>Hydatigera</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000071901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000071901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000071901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251691at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000071901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35353" checksum="5118CAB5123B5E0E" modified="2016-06-08" version="1">MVITESVSHTEGEASNGDVLWMLSHVRPEIMLALIVLTVVAILLSIALSIRCAMTKCYFDSLQQENPDHCLGRCLCFEPTSGNSSISKCRHHNQTPQGHVPYGLILPPPPPPPPPPPPPPTFFTPYQVDQQSESGGLPAYTRNISLSETTTTKLLAQQPPGTLSTASSSDTGTSNPFPVSFSVVTPDVRPVKDIYDRSPSPTLGTLPVYYPGKRDSIEIGSVASDPYNQTKVYLIKMVDPGGDQHHQQQPQKTRIGNSINSTVYDEEVLNSGGRGNFLAVNPTLVRLSSSTEAAGLILCHRLADDGSNLSKTQSEADFAAARRLPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REI2</accession>
    <name>A0A158REI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7332</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020363">
        <property type="protein sequence ID" value="VDM31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REI2"/>
    <dbReference type="STRING" id="6205.A0A158REI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000734701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000734701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000734701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000734701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56035" checksum="0F72102FB6F4DED5" modified="2016-06-08" version="1">MGKASNTSERTSTPVTESEGSSDWLVSDAGEDKKFSYSFGLIASCLGCVLGTGNIWRFPRIVATAIYMTSSMNIKCLNLAYFSAYFSVVVGWCFYYFYVACAWSNLPSTEPESKEIFESFIGTYWPLGLHTLDLLICGVAVFKGVKGIEIANSCMVPIQLIIVISTFYWSLSREYADVGIKFMFSPDWSMFANPQVYVEAACQNAFDTAAGMGLFSAYAAYFTRETGAVRFGTLLPMVNNLVSLVCGLMIFSTVFSTLIQTQPTLTIPQIVTIMKESGPGSTGLTFTWIPVLMSRLGVAGRVLCALFFLCLSFAGVTSMIGYIELTARTIQDFGVKRHLATIAALIVSFLVGVPSALSIDVLQNQDFVWGFALMISGMCYCALVIRYNPVKYRRVIVNDFGLKDWKLPFIWVILIVYVLALRISIPDYFLPPSARLWFILFILLGGLNIVVYCCKWDLLKDSSTQGYDPYRLEEAYAQNDLSKDPSSVFEEDGEEGFHAKSEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF10</accession>
    <name>A0A158RF10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Filamin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8525</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020523">
        <property type="protein sequence ID" value="VDM33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RF10"/>
    <dbReference type="WBParaSite" id="TTAC_0000854001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000854001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000854001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21311">
        <property type="entry name" value="CH_dFLNA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="312"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="618"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="715"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="809"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="930"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1447"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1547"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1744"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1867"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2020"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2078"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2168"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2259"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2349"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2451"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2593"/>
            <end position="2662"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2664"/>
            <end position="2756"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2800"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1225"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1265"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000854001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2891" mass="311006" checksum="91545EC609D19DC5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E864</accession>
    <name>A0A3P7E864_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000751">
        <property type="protein sequence ID" value="VDM18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E864"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="72" mass="8004" checksum="66AC657D69F04A73" modified="2019-02-13" version="1">MPCLLKQAMTCQRHGEVVPNPSLRIVVTLWKVMQTIWSTMATIVRACPPSLSLPQSRVSSMLPTGRPSCFMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EG11</accession>
    <name>A0A3P7EG11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001800">
        <property type="protein sequence ID" value="VDM21741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EG11"/>
    <dbReference type="OrthoDB" id="10476985at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="169" mass="19055" checksum="71B815F9CD38CDAE" modified="2019-02-13" version="1">MGLFEVGIGGFNLLGLIETSCRVDEVLMSKVKEEDSFMAVTMDWSGVWNALTMFEPATVSSIMWGPRLWRIRGEREFLSLKEMNTREAEDWVGSRTFSQAAPVVKTAAVQQTKSHPQVLTPAVWRGVVKNVAKKVGKAITKFAIYEAAEKAVVTAYDKASKWIKRHFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERJ9</accession>
    <name>A0A3P7ERJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005648">
        <property type="protein sequence ID" value="VDM25861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERJ9"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="119" mass="13213" checksum="E52F56B81BF86E9B" modified="2019-02-13" version="1">MASFIIVKQTIGLTFLAGYLEPLYALGNCTAQLDVVVSLAVAAVSAPKPYVRPHVKAHQPNGSGGIHILDFRHPCLEFQDTVSVIPNDVHLERGNYFLNISEMFDLFKVNFESFFALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ET46</accession>
    <name>A0A3P7ET46_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006660">
        <property type="protein sequence ID" value="VDM26510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ET46"/>
    <dbReference type="OrthoDB" id="434939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="2">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25952" checksum="8463A68D6B2A02FE" modified="2019-02-13" version="1">MDLPHTPPGTKIRLIGRVQIRVGFLILRRSNFEVLQGSVDLLCREWALTRVGFLLQFGFHSESICSNFLRKRCNEYHVICHYLYPALSYAVRSKHLNSAKLCIHADSQDAKGTRRSHRTGPDAPPPFVAFGTTEASAMIDSHNNFLNNLWNRNRPKGLLFLLFPKVISIMSTLSYFPTRHALKHRRLCRFIGLHLLITALSTFAFISYSCARGGLGSFSNVCLPMVFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F6X5</accession>
    <name>A0A3P7F6X5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRAPPC10/Trs130 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020354">
        <property type="protein sequence ID" value="VDM31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017966143" description="TRAPPC10/Trs130 N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1515" mass="168014" checksum="A0DF0A0E699964C1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F8G8</accession>
    <name>A0A3P7F8G8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004382">
        <property type="protein sequence ID" value="VDM24909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F8G8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="58" mass="6016" checksum="DB21CDBC783DE1F7" modified="2019-02-13" version="1">MSTSTAHFTKMSSSGISNLIDDADQAIPLAGTTTLSVSPVLTACASMPLVSHSTIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FAT1</accession>
    <name>A0A3P7FAT1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020314">
        <property type="protein sequence ID" value="VDM30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FAT1"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="648"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="738" mass="80975" checksum="B62C8A823F177598" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFR6</accession>
    <name>A0A3P7FFR6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFR6"/>
    <dbReference type="OrthoDB" id="6278539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="543" mass="59481" checksum="F8ACFFB6C2DF131D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQS0</accession>
    <name>A0A3P7FQS0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQS0"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="33"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="406" mass="44321" checksum="43DDCFFAB726B4FE" modified="2019-02-13" version="1">MNHFCRFNHHQDIAISTESRAWEVYHFNGSLKGALENELRMTHTRRPPPIKNAGDLLIRPQAVSLNPIDTLMLTGYGNTVFRMYRRLFSGQTDEFPFTPGRDFAGVVVDYGPHAAPTPFLPGTPVMGATSPHTSSLGGGCLSDYILCPAEVVARRPDKLDPILAASVSYAGLTAWEAVCKAGMDPFKNRSSAPKRVLVTGASGPVGAISAQLARLSGASHVTVTAPSRINPTVLKGLLSVDEVILAPEMSRIDAKYDAIIDRVRPNVLVMARGVSKCPTSRQYEIQKYYPFIRNLESSSSASRYVSVNPPVLQFIDELGLFIGIGASLTSLAYANLYTLLSEHKNAPIRWAFFAPSRKRLEALANWLVQGQLHVPVEKVYSFDQVPAAFQKLSGGGNNGKLVIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G2B0</accession>
    <name>A0A3P7G2B0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021790">
        <property type="protein sequence ID" value="VDM35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G2B0"/>
    <dbReference type="OrthoDB" id="6321109at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="291" mass="33715" checksum="188BFC4A5B1B1944" modified="2019-02-13" version="1">MKSSQYFSMDWQYFCRLMRQIQSYMDKNLAGIHDLLPTHGFDDTVSKLAFATSTLARLEDFSSQINVAMKSLSSSDAVDSPQQRSAEIERIFAKYDSSMMIFARDTILRLDTAIAKLKESTETLQHLQEDWRAYVTDLDSFRNWLLQRALFSKRDRQRSSFEELNQGGERLRNLRDTFRRLSGKRLRVDPELEKLDNDYKSLLYRMCHRESSSPSLHETPEPDSSKCSRTGILADLLQTVQHIKSDVEQADIRAERRRLDPSRDEGGPYNPVHESSPASKPIIEVKTHMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4X3</accession>
    <name>A0A3P7G4X3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021589">
        <property type="protein sequence ID" value="VDM35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4X3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="101" mass="11595" checksum="982AAC38138A40F6" modified="2019-02-13" version="1">MTVVVATPVSEGCMLLVTCCCTRRYGNPRSSSRRMMLDGRVERSMTSTQAVMRNPLLVDKLPKMHWNLCRLALDSCRRCNHREAAFDKVDFQADEEEVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GEP0</accession>
    <name>A0A3P7GEP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001554">
        <property type="protein sequence ID" value="VDM21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GEP0"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="533" mass="58673" checksum="55AC79E9E2750A42" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HPJ4</accession>
    <name>A0A3P7HPJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023719">
        <property type="protein sequence ID" value="VDM36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HPJ4"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="150" mass="15232" checksum="1150ED05CB94E359" modified="2019-02-13" version="1">MNQFNPSTKISSSVPTTPATAAAAAAAAAAAAAADEDDEAETVAGVLDICSTDVVSIFTGAEALRRGSIDPAYPAMSQAPAEALRCGGSTTPLPTSAFVCDEDEGEAEEEANVGTELCLRGSGPKSLARGCPLSFSWRISMAQWNLTAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI99</accession>
    <name>A0A0R3WI99_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000023">
        <property type="protein sequence ID" value="VDM16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI99"/>
    <dbReference type="WBParaSite" id="TTAC_0000031101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000031101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000031101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244748at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000031101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13437" checksum="2AD13F97B1FF6EB6" modified="2016-01-20" version="1">MARRWNANSEPYNAYLSPRQVDQLKPENAFYTTEFGDRCERHYCGACGQCHPTSSCASMRLLEHVTGTSLPDAAFHASEAYVIDDYAQRRFQAERHKLRLEHHCKPTEPFPFPSETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIK8</accession>
    <name>A0A0R3WIK8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS441</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01000038">
        <property type="protein sequence ID" value="VDM16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIK8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIK8"/>
    <dbReference type="WBParaSite" id="TTAC_0000044001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000044001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000044001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000044001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42788" checksum="B97A9A44FC8C621F" modified="2016-01-20" version="1">MMPVTDTPAEYSAPIPQVPPNFHVETVGESQFVIPDRYSGLRPVGTGAQGYVVSAFDSVSQRKVAIKKLAHPFQNVTHAKRAYREIVLMKLVNHRNIISLLDAFSPQSTLDEFQDVYLVMELMDASLSHVIHMELDHERFSFLLYQILCGLKHLHVAGIIHRDLKPNNIAVKHDCTLKILDFGLARSGSENFMMTPYVVTRYYRAPEVILGMGYTANVDIWSVGCIFAEMVLERTFLPGTDHIDQWSKITAELGTPSRDFIDRLDRDVRNYVLSRPHVPRRPFETLFPDDVFPEPSRVYLNPAMARDLLSRMLVIDPMERITVDEALRHPYVSLWIDDAEINGVRHPSLSATRLVSKYHEFSRLLMSLTTAIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJR0</accession>
    <name>A0A0R3WJR0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS924</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000130">
        <property type="protein sequence ID" value="VDM17183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJR0"/>
    <dbReference type="STRING" id="6205.A0A0R3WJR0"/>
    <dbReference type="WBParaSite" id="TTAC_0000092301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000092301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000092301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054509">
        <property type="entry name" value="LARS1_ULD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22947">
        <property type="entry name" value="ULD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="668"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="807"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="15">
        <location>
            <begin position="967"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase ubiquitin-like" evidence="14">
        <location>
            <begin position="1095"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM17183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000092301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1216" mass="137005" checksum="A5ED7BB003ED587D" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK19</accession>
    <name>A0A0R3WK19_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TTAC_LOCUS1047</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000165">
        <property type="protein sequence ID" value="VDM17364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WK19"/>
    <dbReference type="WBParaSite" id="TTAC_0000104601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000104601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000104601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1111"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="1301"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="956"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1364"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1688"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="956"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1699"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1718"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1747"/>
            <end position="1766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VDM17364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000104601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1766" mass="193342" checksum="69FE44B117D2880B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKE9</accession>
    <name>A0A0R3WKE9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TTC5_OB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1188</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000207">
        <property type="protein sequence ID" value="VDM17596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKE9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKE9"/>
    <dbReference type="WBParaSite" id="TTAC_0000118701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000118701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000118701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423589at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032076">
        <property type="entry name" value="TTC5_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038645">
        <property type="entry name" value="TTC5_OB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16669">
        <property type="entry name" value="TTC5_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 5 OB fold" evidence="1">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000118701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="30976" checksum="038BAFE8AA280C8B" modified="2016-01-20" version="1">MHVITISEGKQIPDQLLFSLVIRTLRFCDLSNPLTLLPFNERLDNFSGALSNWFKAALLDPAWPAPRTNAIRCLNALEKIHTTVHALESKTATKATRKRVASLISLLSSSTNSMNRLLGPFQSYRYQTFADLAKGSNPGVVCCGGVVTSLPADSELTLNLLLVDAMGAFLAMRIFQIGKGLGPSTKDVVAIPNPILEHCMISADLIRLIRAFDACVRAEGAESAEEEDSELGQGDTKVLDLDHLESLHFLVLRVSSPHMLCVNGSRVGRAWTAAAVPKNVFFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKP0</accession>
    <name>A0A0R3WKP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1286</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000247">
        <property type="protein sequence ID" value="VDM17744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKP0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000128501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000128501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000128501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946219at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF54">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH2" evidence="3">
        <location>
            <begin position="36"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000128501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29698" checksum="779B37D2AFD24FBC" modified="2016-01-20" version="1">MLTVPRALHLTERQENAFTNQGDSGCILEECCKKPWSHISYWECNRHIGHKWLPVLTSALVVLNEEPYSVSTATSENPSTHAIWSQQGRLCLDRLVRHFTSPRSFSEDSHPSRKKYWPPIPYSSSPTKQRRRLSHEGISLLLLPKGQILLTNKTPTTPIFVASPCFVQQGDLIAGDWPVYRVAPTCSLVVFDTRIYEDRLTEACKSTSWPGKSLFGPVLHISLGKGWGPTYRRTDFTHCPARLEIWLNLSTIKSHTSSSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKZ5</accession>
    <name>A0A0R3WKZ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1409</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000300">
        <property type="protein sequence ID" value="VDM17949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000142201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000142201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000142201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM17949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000142201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14302" checksum="6A56F0F70523AF23" modified="2016-01-20" version="1">MGRGFYGGSRGSRGGFRGGRGTGSRSFEQEPLEAIELVGEVSHTCQRDLVCKLLNEGVPFFNAPIYLENKQEIGKVEEIFGPIKKSLFSVKLSDNLNTESFKEGQKMYINKFKLLTMERIMSFNAPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK9</accession>
    <name>A0A0R3WLK9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1634</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000419">
        <property type="protein sequence ID" value="VDM18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLK9"/>
    <dbReference type="STRING" id="6205.A0A0R3WLK9"/>
    <dbReference type="WBParaSite" id="TTAC_0000164701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11789">
        <property type="entry name" value="SH3_Nebulin_family_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25908" checksum="7B4FADC2EA15C0D3" modified="2016-01-20" version="1">MPFEHGNEVSRAVEAPQLQQQQQQQNYNQPSTGCGERYIYSCGRDVLKFKFSCKTIPLKHYKHIYLTDGQVKRSSLNPESYSFPQPPMNTTNGNTQGSYANANTRVGSAPKNDYMERNGEKSSINPFLNVFPFDLLHRVEEESDAVPIYRPDLVMMGGMKVTGSGMHFQAVYSYEAAEDDEVSFVEGDEILHGEPIDEGWMFGTVRRTGRFGMLPSNYVVPIQNPNYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM47</accession>
    <name>A0A0R3WM47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuole membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1822</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000535">
        <property type="protein sequence ID" value="VDM18562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM47"/>
    <dbReference type="STRING" id="6205.A0A0R3WM47"/>
    <dbReference type="WBParaSite" id="TTAC_0000183501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000183501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000183501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000183501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52615" checksum="F538626ED4EE3205" modified="2016-01-20" version="1">MNNVERPSSIRSKKQLLAEHTERRSLKLWRTPLKTAYYFLLECFYQCASLIRNILRHKFATCLSILTFVVFLSVRSIGGPLQESFIHAEKRAIWYGWWILLGFLSSCGFGSGLHTFVLYLGPFIAQVTLSAYVCHSLDFPEPPYPDELICPTLNGTHKDVSFLKIVHKTELESVLWGLGTAIGELPPYFMARGSRLSGSINADEIELSLNNTSSSSEVETDSILPQTSEKRLSSFQRVEVFLQRLVTRAGFIGILLCASVPNPFFDLAGMTCGHFLVPFSTFFGATCIGKAFIKAHIQQFAVIAVSSEDHINLLVKYIGKLPLLGKRLQRPFMEYLEHQKEKLLQKGAPPREGWIQFAITLIVTAAMIAFILSIINAMAQSYHRRMCKQQTSHEKTKLVSKNSFFWTKKNGERQKPKDFEQRHLRSVSSLRRRIDSGGGGGEEEEEEEEGDLPFVEALLGRPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM85</accession>
    <name>A0A0R3WM85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1860</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000560">
        <property type="protein sequence ID" value="VDM18600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM85"/>
    <dbReference type="STRING" id="6205.A0A0R3WM85"/>
    <dbReference type="WBParaSite" id="TTAC_0000187301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000187301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000187301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF81">
        <property type="entry name" value="PROTEIN RETINAL DEGENERATION B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000187301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41545" checksum="7356077C2D514B97" modified="2016-01-20" version="1">MHADDGRRIPDRAAIYDPVNLTNHIIDLMVVAEFRSFHNFPILQKKSREESTGRESGVEILKNTPYTDGPGGNGQYTFKIYHVGSHIPGWLRTIIPDAALRVEEEAWNAYPYTKTRYRVPFMEKFSLEIETRYLDDAGESENVFDMSPAELNTRIVDYIDIVTDPLAPAKPAEDPSVYVSQVTGRGPLSAGWRGEFQEAMRTGRKYPGQGTKPDATGSVPTEPLPMRIMCSYKVCRVDFRYWGMQSKIESFIQDYALRRTMVSAHRQAWTWQDEWYGLTMTQIRQLEAETAKALALKMGESAGNSLKITTFSPDSASAAITDHQQGQQLDQDADKKKVDGGGTGDEAVASAVNFGSCMSFTSESERGRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMA8</accession>
    <name>A0A0R3WMA8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1883</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000580">
        <property type="protein sequence ID" value="VDM18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMA8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMA8"/>
    <dbReference type="WBParaSite" id="TTAC_0000189601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000189601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000189601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="114"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000189601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="43245" checksum="301A48429456F281" modified="2016-01-20" version="1">MPVPKKKTKNSSYFSHEFIIANHGDIVSVIAMVFIGGMLFPGPSRIASLFVAMQHNASNEKVDSMSDVVYTTGRYDLLAIFFYTLICIIMHAVIQEYVLDKMSRRLHLPRFMQSKLNESGQLLLFYMFSVYWAVYALVNERFLTSLDGLWSGYPHAVMPFWIKVFFIVQISYWLHNFPELYFQKIKKNEMPNRIFYSSLFLIGVSAGYFMNFSKLAMILVILHYFTDSFFHFSRLMKFYGYIAAVNFGFAVYNGLYIFSRIMCSVLAFLTFYIPTMNIANGNFNTCLIRLNCMLFVLFTQAHMVWTFSNYHFTKMRERKAQQHANNVYITNNDLQKRKDKQQKKAKQEDVRESPNHSNNGVKQKKQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WML2</accession>
    <name>A0A0R3WML2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 7">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1987</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 7"/>
    <dbReference type="EMBL" id="UYWX01000663">
        <property type="protein sequence ID" value="VDM18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WML2"/>
    <dbReference type="STRING" id="6205.A0A0R3WML2"/>
    <dbReference type="WBParaSite" id="TTAC_0000200001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000200001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000200001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000200001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52413" checksum="FD1B2DB306223B03" modified="2016-01-20" version="1">MLHLNNLRYRGEGNNNIVLADGNGMVYRVRKVSPPALLPTKNTRALKKNRQPTVLFGQHRMAQYFGPDFVQPFQLIDVDPSILQAINDRFQSSRPVFRLNRGIDLQTTRVLAAPDATCIPAELVPYGEGSVLCVEIKPKFGAIPLGPERDSFEATVRRNAMFCIMQYDEKKRRMWGQPSSYCPCDLFSGYNCLLFSQTTSYRLNQDRMLRALLAMFEVRQNNLRVFRNSCCVLNNTIDLLDNALMDFFYPSLSGCEGRGENYNSSGNSSEVIPSHAPEEFSSDGDCDSETTYHLRGCQLHPAGEGSLRHRFVQGLLLPALLTETPSSSVPRSIRRSSKFRYDCDLHPYTPSTSSNGVDALATTDSYIAGKIVVNTAEVPPCLIESLNLVEKHLVAMVARDCSIMLTFQRAKDNCLTNLLAVGGACPCVPRSIVNISIVDLDPKELNNLQERVEAERRVVEQFLIRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMN7</accession>
    <name>A0A0R3WMN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000683">
        <property type="protein sequence ID" value="VDM18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMN7"/>
    <dbReference type="WBParaSite" id="TTAC_0000202501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000202501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000202501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000202501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19037" checksum="4F6B08D7E9A474C5" modified="2016-01-20" version="1">MNWRTGLSLAFSALISAIIAALAAIYYTEYDVERAFCGNIFDFEDELPPNRFVLVRYLYVLSISLNYLLPVTAAILYYSEVLEALKEFDAPIAVIEEAEKFIRLDGHLLLWLGAPIHMLESIQLMHWKRELLHGKFYAKVFTMLAGAYCIMQPTLHIVLNMASRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMP1</accession>
    <name>A0A0R3WMP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2016</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000686">
        <property type="protein sequence ID" value="VDM18756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMP1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000202901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000202901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000202901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6086776at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000202901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56214" checksum="951F7D6B509232F5" modified="2016-01-20" version="1">MCETEKHSEIKSGQFMISKLDDSDSENGESESHEELESSSSDRNSGIPAFDTLQSLFKSLSLAYVETVTSPRWSHFRGAGFALKQKVRLNNIIWREYHMQYVKQRLPVIVKFQVPSPQTSGIKIQSPVMDGKLWDRHCAKLSSEYRRWRTYYISHLRTKTPNTSRSDKRRLDFELLVDFPSKIQYVDDKDIFNDVSNFSGVGSPRFIDELMKDFDGSLDLFLDQPFPDPRDVSMLGNSDIMQPALTQLQPNSENYRSDLIAGLLQQPAMPTIMEDEYGNASNYQPSTYASQNHFSFRQSNSPQVTSKPTFRAYSPPQPTVLRESEYCYGSAVRKRFPALQQPPPPPPPPPPTTFAPKALRFVDHREEACTTGKSRNNLTLLNALLQKPGPGVRERHHSTSSPSSPETTSVVAGGTTNSVHFKRQVSMSPANALIVDLSKEQMASPSPGVYLDKSLTGFSDATHVSSHSSFTKITFVKWPHGNPEIVILLFSSLAMQMGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN69</accession>
    <name>A0A0R3WN69_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2194</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000839">
        <property type="protein sequence ID" value="VDM19193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN69"/>
    <dbReference type="STRING" id="6205.A0A0R3WN69"/>
    <dbReference type="WBParaSite" id="TTAC_0000220701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000220701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000220701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236903at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM19193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000220701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37889" checksum="69D92A9DBD0C505F" modified="2016-01-20" version="1">MVEFKSTSLDRVRGSQLTGARLLLNPDSSYPRIVEEGINLMPGTLTDIHFTVREWSMMTPPYGRCSHEAPVEIGFGGQTYSYTEQACQQGALQEMIAQRCGCLSYDMPVPNHLEGNATTNASFYCQFFELPVVNISTRSDTEIRRRYFTQKAMEGFITRMYCSTAITRNTLAAETGCRAPCIRYSYDTQISTAQWPTKRFITNFANSQLSRKMHTVKQQGERNSQGEEDDERRFVKLLRPYATIYNMTSNGKEMEAVDLLMHLQDVEQNFLSIIVSRPNFDIIRVDEKAVVTLTSLFSQIGGLLSIWVGITMICIVEVAEFLLNCFDVLCGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP42</accession>
    <name>A0A0R3WP42_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2517</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001165">
        <property type="protein sequence ID" value="VDM20322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP42"/>
    <dbReference type="STRING" id="6205.A0A0R3WP42"/>
    <dbReference type="WBParaSite" id="TTAC_0000253001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000253001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000253001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM20322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000253001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14019" checksum="C85A54EF866C999D" modified="2016-01-20" version="1">MRKDKSTKSKTSQSPEPVLPFITPPDREIQVTVKCFCMSEEMLNYAAVSAEEALKRFSTRKDVAAYMKKEFDEKYGPLWHCVVGRDFGSFSYFSYVTHQEHGFVVFRVDDWAFLLFSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPA5</accession>
    <name>A0A0R3WPA5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2580</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="UYWX01001239">
        <property type="protein sequence ID" value="VDM20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPA5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPA5"/>
    <dbReference type="WBParaSite" id="TTAC_0000259501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000259501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000259501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="181"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000259501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67833" checksum="5FE56C40E0A0B623" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPD4</accession>
    <name>A0A0R3WPD4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N_BRCA1_IG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2609</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001279">
        <property type="protein sequence ID" value="VDM20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPD4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000262401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000262401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000262401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000262401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24429" checksum="E9BD66C226C9D478" modified="2016-01-20" version="1">MDFSNSEIDAQLLEQFRCLGTDDRDELVKNFNHVVGENVSSGICHFFLDLANWNLQKAIGAYFDFNFDVNTDTSHSSAPSFRIQPLLFDTSPLIWCVQNSGTASWPEGTYLTVETAPDLATIPLCDKSVVWLPLPSGYRKPVSELSPGSYAHLVVDVQPPPEDICSRALSTNTPVIGALKLCLPSGARFGGKSFVKAKPLVEPRRRVKCSCYRSVRALIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQB0</accession>
    <name>A0A0R3WQB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2935</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001699">
        <property type="protein sequence ID" value="VDM21548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3WQB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000295001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000295001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000295001"/>
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    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM21548.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000295001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31804" checksum="B5558BF299F2AFD5" modified="2016-01-20" version="1">MTKLQTGSVLYEWHMKEQKAINGKGAFQANPLPALDDFVPMSPVKVSTGGQGTVAWVHLPNTSMQYALKFKVRDGRSEKNWLIERREAKILQKLKHPFIVNTYHIYETDDALFMAFEYLSGGCLWSHIARLGTLPECYAIYYAACILTALSYLHARGIVYRDMKAENVVLDYRNRPKLIDFGMAKYFPSVRKQMQLDGDSGKRICADQSLGKELVREPQSIWASPDLNTDIETDDPPTKYYYAAYLAPEIYSQPAEANHYIDSWGLGYIILEMILGYGM</sequence>
</entry>
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    <accession>A0A0R3WQT8</accession>
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        <name evidence="2" type="ORF">TTAC_LOCUS3113</name>
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    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="154"/>
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        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM21978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000312801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22370" checksum="CAD424511E7B9775" modified="2016-01-20" version="1">MSMKLMYWTNLKWCACHSEGENSTLTTSVSLHFQQKDALTVRRMESPFSPSSWQDKDFLAPWRSTHLNKMAGDTHSVNFADHSGGFRQSSPAPSICSSRSVAGSSTVGRHGIGPTPTGSLIVFRVHSAITDDAQSLVEFLTILLSEGIFEEGERSSVNFPEPGTSSVTKARVSRDGTVECSPRGDAPTFWKLGSRNEVDQERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQZ9</accession>
    <name>A0A0R3WQZ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANAPC4_WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002020">
        <property type="protein sequence ID" value="VDM22104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000318901"/>
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    <dbReference type="OrthoDB" id="10438496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000318901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="17085" checksum="658C10EDE37296CA" modified="2016-01-20" version="1">GGDRSVIASRSAISSNAAGCGGSGFVCLAWSADGGTLAGLSDRLCSWRLITRPNTSCAVGGSGGGFHQVLDRSRVIRVFDTTDRRNRLFVSCASPGSPYLPSTLIVLEVHSGICFVFDPIEMIAPPTSNTIGDGGSVPVVGVSAPAATLAAAPVTTILSDVTSMLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS72</accession>
    <name>A0A0R3WS72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3597</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002703">
        <property type="protein sequence ID" value="VDM22948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS72"/>
    <dbReference type="STRING" id="6205.A0A0R3WS72"/>
    <dbReference type="WBParaSite" id="TTAC_0000361201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000361201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000361201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF173">
        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="125"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="390"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM22948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000361201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="858" mass="93565" checksum="4E11B5E84BA141C5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSP2</accession>
    <name>A0A0R3WSP2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HCO3_cotransp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3768</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003013">
        <property type="protein sequence ID" value="VDM23326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSP2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSP2"/>
    <dbReference type="WBParaSite" id="TTAC_0000378201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000378201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000378201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277211at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="156"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000378201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38414" checksum="BB4CB1DE84315184" modified="2016-01-20" version="1">MHSSSAKMRLLALECRPEFNEVHKAYTISLNIVATGVFTILYSLFAGQPLGSIGLSGPGFYLETVIALFASLLGLDYWVYRFWAGIYMIAWGIILIGMNLSSMVLYARRSLEEIFSAFISLFLIIKSILFLFRAIPGTVYNATDHTDIVQMNEALSSSQIASKAALQLFLALTMLVFSLLINKLKRGHLFRRTFRYWIGAFNVPLGILFVTVLTYIFFSTYPIIKLGVPPASEADPKAWINLVQFSELTTIGNYPALVHVTALIVGFFYCLLVFTEIALNSVTALKPKAKKPSPFVMDHVLTNVIFPLISCILGWPFMSGVPVRTIANTMALVKVDPHPPPGKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WST8</accession>
    <name>A0A0R3WST8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pru domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3812</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003097">
        <property type="protein sequence ID" value="VDM23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WST8"/>
    <dbReference type="STRING" id="6205.A0A0R3WST8"/>
    <dbReference type="WBParaSite" id="TTAC_0000382801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000382801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000382801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000382801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28007" checksum="C80D4BF5ABF32091" modified="2016-01-20" version="1">MSTGLFDRQPSKPQARPLLQFKAGKMTMNPDNSVHADARKGCAYLYQTPGDCSVHFCWFDRRTGLIEENFVLVPREAEFKPVPQCKSGRVFVLKLSAPQRRFFLWMQEPNASNDAQICETVNKFINTPPAPIGSSVAGSLVSSRSAGRMADFFSGMRGLSGMNQNDLLTLFSMGMGFGFSSEGESSAQALPVPTGRLPFSSRVEAPAMHTASSSSVSAIPASNSAPAATGSSSSTGDSQPGKLRLQDLHSILSAIQSATTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSU2</accession>
    <name>A0A0R3WSU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3820</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003106">
        <property type="protein sequence ID" value="VDM23472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSU2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000383201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000383201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000383201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000383201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22102" checksum="5784A0325531C25F" modified="2016-01-20" version="1">MRAGINNLVVDNGSGMCKAGFAGDDSPRVAFPTVVGRLRQSGEQTERYVGGEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRLTGIVLDLSHGVSHIVPIHKGYSIERGILYLEVAGANLTDWLMKLLTERGYAFTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTK1</accession>
    <name>A0A0R3WTK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4076</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003616">
        <property type="protein sequence ID" value="VDM24125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTK1"/>
    <dbReference type="WBParaSite" id="TTAC_0000409101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000409101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000409101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244800at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000409101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15440" checksum="D447332408D366F3" modified="2016-01-20" version="1">MNRVHKLTAALLVLIILSLILSLLLPYWECGYLLRECIEGGRVNRDVMLAVAVLLVSGLILLSADLIVEVVRLCVTPMPTGAVTVRFLFTYLGSLSTFCGVLVYTGLVMGRWAYFLAIFGATIAFVVQKLAMISSRCVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUJ8</accession>
    <name>A0A0R3WUJ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HCO3_cotransp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4423</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004375">
        <property type="protein sequence ID" value="VDM24903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUJ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUJ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000443801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000443801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000443801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM24903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000443801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25851" checksum="CAB83474428BBB3D" modified="2016-01-20" version="1">MVGYLPCLTKSLYLLIRLVTDPAPKLLGMVEVDVGIRFVLLALTPRVNEERAMYQTGRCFATMLNENKFLTALRHSHDPGDIYKAAMNFRRDIIVISHGYSEVLNRSGGIDVPSPYANEVEFDRTDLVFDDVLDATSKNEMMSSNLSLQIEPQAHCTKHSFKRLCPPFYELVRGIKALAARMPSDYVDAFTKDNVGTMLSSILFIYFVVFAPAVTFGTLMCKSAYFLHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUL5</accession>
    <name>A0A0R3WUL5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004440">
        <property type="protein sequence ID" value="VDM24951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUL5"/>
    <dbReference type="WBParaSite" id="TTAC_0000445501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000445501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000445501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052054at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000445501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22024" checksum="2F5E1EBE34DAC390" modified="2016-01-20" version="1">MTDRRQSVAPSTTFRWRSRSMASDDQENVERDQRMFPSAFRTASVATSHLRRMTKMFSIDKTREVIRTALEDSDHAEYVRLACEHEELTKEVKQLRGFVMELCERYEAARAIDPLRRYKRMQSMAKTIVLQLRVNDPSAASSGGYSAVNDSGYDTFDPSAVGASALIVGDVLQSSVKQKEMRLKHEKMARGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUP4</accession>
    <name>A0A0R3WUP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004526">
        <property type="protein sequence ID" value="VDM25023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000448401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000448401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000448401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10313620at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000448401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11785" checksum="918017B01CFFBE38" modified="2016-01-20" version="1">MPIIVEGNEELENHTVERVEASMDNTPNGGSGASSTAAVTAANDTFAMVIHHQGTSDIAMVSGHASSFEETEIFVQPVKEESVSNAFYPYAWVRMLNQSAVTISQQIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUP9</accession>
    <name>A0A0R3WUP9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS4474</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01004540">
        <property type="protein sequence ID" value="VDM25032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUP9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUP9"/>
    <dbReference type="WBParaSite" id="TTAC_0000448901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000448901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000448901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM25032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000448901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22995" checksum="EDAEF31C72DF9CB5" modified="2016-01-20" version="1">MENVYPQFAKTVYKEVRDIMDSGIDGVKLFLNEADFTVIQAMIDGPKDTPFEGGRFNIKLVLPSNYPTDPPRGYFTTKIFHPNINWHTGDICVDTLKKEWRSDLGLRHILMTIRCLLIAPNPESALNEEAGKLLLEDYNEYTKQARLFTEVHALAPDITKRSGVEGGAAPSTLRDSNGQANAKLKKSMKAQKKVSVARKMIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUR4</accession>
    <name>A0A0R3WUR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4489</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004580">
        <property type="protein sequence ID" value="VDM25054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000450401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000450401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000450401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000450401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="6730" checksum="6772D34B429BFFE6" modified="2016-01-20" version="1">MNGCMLVGKDRNCIEVDVYGVYSALAPIGVDKTAGGPDACSTSPQRPSPLGEGDSAEAINAACKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUR8</accession>
    <name>A0A0R3WUR8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4490</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004582">
        <property type="protein sequence ID" value="VDM25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUR8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUR8"/>
    <dbReference type="WBParaSite" id="TTAC_0000450801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000450801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000450801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="99"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000450801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27404" checksum="B5E6E09868EB4648" modified="2016-01-20" version="1">MVLKDKVLAKFEKDQAETKASKSHEERLRMNAEILKEILFVYFKVLKTTKDSDLLSAVLAGLSTYAHVINVDYVENLLQLMSSFVTNPKTSLQDGLNSVHTALTIFNSSSAAAVLKIDPTHFYNHLYALLGCMAGVRGRRMGGAASNTVKSNNLLQYAWARTPAALAAEDLVKRERLLAGSDGSDQSNEFVRSISAAEVEDFADVILACLDMLLVSRRKEVSITRVLAFVKRLASLTLVVTDTACLASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUY8</accession>
    <name>A0A0R3WUY8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PhoLip_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4563</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004764">
        <property type="protein sequence ID" value="VDM25191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUY8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUY8"/>
    <dbReference type="WBParaSite" id="TTAC_0000457801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000457801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000457801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="8">
        <location>
            <begin position="69"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000457801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34735" checksum="5252E5A22AC17DC4" modified="2016-01-20" version="1">MNVTTVLCCRMTPLQKAAVVRLVSHGLDGVGGGGRPVTAAVGDGGNDVAMLLEASVGIGIYGNEGRQAVRASDYAMPLFRHLRRLILVHGHWNYYRISMTANIFYFKNVAFVAIQLYQMFYDGFSGQSMFDSLFYTIYNLTFTFVGPFLYGIFEQHISSKDLMHRPYLYRLMNLSANLRCWYVLLWVVDGWWHGTVIYYVCYCVLVGGMNFSEAQFFQSDTSYAVVDFNMFSNACYIYLVVTVTMRIVVMSKYLNRCIIIGLFVTGFINLAIMYIYQRSHDKISMPPPPPAVRSLVLLGGDDLGDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWJ2</accession>
    <name>A0A0R3WWJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CTNNB1 binding N-teminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006298">
        <property type="protein sequence ID" value="VDM26302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000513201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000513201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000513201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000513201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11910" checksum="32F690F9F623AF7E" modified="2016-01-20" version="1">MNMEANRKCAENSEEQNSHSSDTDYDYESSQHFDVHATPGCGADYASNSRIVESTFGGAGAGIERGRGYAGLACFPNLDERSSVVRYGGGMKGMQHSIALDRAVCFSTAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWQ0</accession>
    <name>A0A0R3WWQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Interferon-induced very large GTPase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006485">
        <property type="protein sequence ID" value="VDM26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWQ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WWQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000519001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000519001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000519001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000519001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23093" checksum="0735CEBADDDA9E82" modified="2016-01-20" version="1">MATCHTLHRLDARTERQTRILLSIDATASPSSPWHRLSEFCHLLCRVFTSSPKGEPGSLWHLGDSCETAQENEAATLKRLTETKPNVPNVFILLVCTQDVSPPCDSELHSGQACDYWQMVLEACHLTVFIDEPTEGPQQRQDDAGLSSLMEAHCSTESNHYPDAEPSVGAWPVSLSFPEFFVEEHPLADINIIKLKHLLTHMAFLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWW8</accession>
    <name>A0A0R3WWW8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Surfeit locus protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5243</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006731">
        <property type="protein sequence ID" value="VDM26551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWW8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWW8"/>
    <dbReference type="WBParaSite" id="TTAC_0000525801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000525801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000525801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000525801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29327" checksum="EE69916E1FAA7B47" modified="2016-01-20" version="1">MRVVRRSRRYLPHLARFCLISTFIEDGLRLLTQWSEQIDFIRHVWGVGSFLAGLFILLNILLQFTGSAFVMVRYRVRVGCGILLATVIIQTIGYNIWTRIFLMRNLSLIGSLLLLIAEASQESKSLLAGLPSVGNENRSRQYLQLGGRLLVVLMFLTLVHWGGSFFYLIQSILNLILILLVAIGYKTKLCALILVSWLTCMNFYYNDFWSNYSDEIMWDFLKYDFFQTWSVIGGLMLIVAHGPGGVSVDDYKKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX15</accession>
    <name>A0A0R3WX15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006896">
        <property type="protein sequence ID" value="VDM26629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX15"/>
    <dbReference type="STRING" id="6205.A0A0R3WX15"/>
    <dbReference type="WBParaSite" id="TTAC_0000530501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000530501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000530501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000530501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28215" checksum="61BD435E8BDB7FA2" modified="2016-01-20" version="1">MCLAAEQTGLDAAMVIRECLAPTVEGVLAETDTPVSSTTPPETSLLSLLESAANQVSITATAMEHGEFDFDGTKKPKTQEPIIQRAIAYRKAQSELESCRGKLELKEVELLELRRELKARVDEISEMTVRINMTEKKLETSGRGNLEKIVELEDRLQAMQNQQKRTEKEYEQTIDGMQTDLVELKKENAELKESLRKTGKSTIGFGLMKPSGLSPGELSTEEIGTPVSPGPRSLASKISAYRDASNWLAEVGMLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX29</accession>
    <name>A0A0R3WX29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006956">
        <property type="protein sequence ID" value="VDM26659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX29"/>
    <dbReference type="WBParaSite" id="TTAC_0000531901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000531901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000531901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000531901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8221" checksum="8362C8C84F13FD11" modified="2016-01-20" version="1">MLVNVLKICSDDELLSDADDTFEGESNYLLIYTPPSVFYPLSLSMHTCARVYSFPLVTALLPFSANSCDDSAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX49</accession>
    <name>A0A0R3WX49_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007055">
        <property type="protein sequence ID" value="VDM26702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX49"/>
    <dbReference type="WBParaSite" id="TTAC_0000533901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000533901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000533901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000533901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7946" checksum="AE1F4F0B626EAAD6" modified="2016-01-20" version="1">MLEDNIRHQQRGYARPASGILAMGRCESGRAKAALETKNRVAKHVAACSEAVKYTLTKCSAVELGEDERLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXI1</accession>
    <name>A0A0R3WXI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5456</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007612">
        <property type="protein sequence ID" value="VDM27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000547101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000547101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000547101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000547101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31395" checksum="EBEF9C3853BB789D" modified="2016-01-20" version="1">MRRDEGLRDEEELRNALGAEKAACESRMAALESSFMATNPCSSVERDVDRVQMQMSSLAQRLSDISMTVARLKGGFSVLERAIALQNATTQRMPIENLRLEVPSSLDAVKNPSMEVTNLLYTMMSRQMSKMASLNRVADILRTVRTILLNRQKEIELKFEPLQEALKTAVVSLTTSLDKTFKRAREKAEENYQCNCEALRDLRNKEMETRQLISFLLKKFSLREETKVASADDYVVSVDRITNYRKMVHQLGESIKLTPLEKYTVSTEALEQVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXM1</accession>
    <name>A0A0R3WXM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5496</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007732">
        <property type="protein sequence ID" value="VDM27092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXM1"/>
    <dbReference type="STRING" id="6205.A0A0R3WXM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000551101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000551101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000551101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000551101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12565" checksum="20923A8F1103FCC6" modified="2016-01-20" version="1">MVEFTSDLHPGVTDKNHVSEIQRLTKESDELNHRVTYLHKTLQEREGKLEQQETELARQKEESATAKKKTHGLEIEMKSLREEMTYKDERLRQLQVQHVGSKCMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYY1</accession>
    <name>A0A0R3WYY1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5956</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009931">
        <property type="protein sequence ID" value="VDM28050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYY1"/>
    <dbReference type="WBParaSite" id="TTAC_0000597101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000597101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000597101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000597101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23599" checksum="122AB480D7C724DE" modified="2016-01-20" version="1">MRKPTFTARHYPEMWTTFIAIGEPKDVVGKLEGYEVLMKSGGLVSVHPWGSVANLSILDWHYRISGIEPLSTYTVTVRGRFTSNEYSAMADPVEFMGVNEARSAPQNLRLVALDSHRVRMTWDPPLQSYDFVTAYSVGLIIDGYLMTPFTVAKNRSFTYTRMEPGQKLSAFVRATSLSTTLTQLELAGRKSRLVSIRTPPSSGGELHPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZI0</accession>
    <name>A0A0R3WZI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stork_head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000620301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000620301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000620301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6228771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000620301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9002" checksum="68363B345EDCEC6E" modified="2016-01-20" version="1">MRLEEVIFQVICQVNMLEPTCSESRLYGHLANIYAEMQSHLPPRQSVYAAISALIKSGLIYYCGKSQQSHSELVVNDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZL4</accession>
    <name>A0A0R3WZL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Integral membrane protein GPR177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6229</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZL4"/>
    <dbReference type="STRING" id="6205.A0A0R3WZL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000624401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000624401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000624401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="10">
        <location>
            <begin position="243"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000624401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66049" checksum="92411108FFAAE8BD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZP7</accession>
    <name>A0A0R3WZP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6269</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZP7"/>
    <dbReference type="STRING" id="6205.A0A0R3WZP7"/>
    <dbReference type="WBParaSite" id="TTAC_0000628401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000628401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000628401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064338at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="378"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="631"/>
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        </location>
    </feature>
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        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
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        </location>
    </feature>
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        <location>
            <begin position="718"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000628401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="750" mass="83969" checksum="BB4E076A2ECA637F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZX3</accession>
    <name>A0A0R3WZX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dolichyldiphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6364</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZX3"/>
    <dbReference type="STRING" id="6205.A0A0R3WZX3"/>
    <dbReference type="WBParaSite" id="TTAC_0000637901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000637901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000637901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000637901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16157" checksum="6CF09551292385E5" modified="2016-01-20" version="1">MDFANTADISSYGMPSNHATFMFFMMAYFLLFIKYRLSPLHYSSFSRAFIALFLLFISVITCYTRVYLEFHYVDQVCIGALIGSILGSLWFYVVHAILTPRFPQIVESKIGRALMLQDFTHIPNIFTFEYNAVKTFHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X009</accession>
    <name>A0A0R3X009_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septin-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6410</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X009"/>
    <dbReference type="STRING" id="6205.A0A0R3X009"/>
    <dbReference type="WBParaSite" id="TTAC_0000642501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000642501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000642501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="172"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000642501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39928" checksum="B385114FD1C924C3" modified="2016-06-08" version="2">MSLFSLVHFFFPKQVNLIPIIAKADTMTVEECRLFKTAVQSQLLREDIHTYDFPLSAIPETCSVATTTADSRIAEVKRLRLRQPFAVCTSSHVITKEDGSKVRCRVYPWGTVETDSLEHNDFQALKTLLMRHFMQDLIDVTYTTHYANYRTNRLTDIMEAAHFNLHDGREPLSQLDAERRAHQIKLDKLVEEMNQVYVEKVREREKRLKDSEREIAEHVRQMQQQLEAEAENLATARQAFNDERVAWEMENRDYADPDFPLNIVTITRTWSAGLLASSWRKLRSCSRSRKRQWMSQRSQRPSSAPGREPTLTSPSVTSSTTTDVASYHVTHNSEALLAPPLAQMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X046</accession>
    <name>A0A0R3X046_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6455</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X046"/>
    <dbReference type="STRING" id="6205.A0A0R3X046"/>
    <dbReference type="WBParaSite" id="TTAC_0000647001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000647001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000647001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="257"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000647001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39128" checksum="2DC33DBD96A4023D" modified="2016-01-20" version="1">MAIYRSEMSVPIRVDTSGTRQPTAVPIVTERGYSTLGGKSASSSSWLDKSHDEDLFGRFNDSLMGVRRSDSERWFEDMRRRFDERRRQWDAEMREMRSSFFNTSAFPLSRPETLSSVPTHHHSPPSNVEDCPVVTNYERGVDGNLHFLAQFDVQPFHQDDVHVTVRDSQIIVTAIREQRIGTSSTSKQVTKTVDLPKGALEPLITASISVDNILLVDVPIGSATHSLSFNTTSGSSGTSGLTTPSTLSGTGRNSHLSSRASPTPTFLSTQTRPKFHVEIPVGSDYKPEEIQIRTLNNRVYVSARHEERQSNRSTFREFSKEYDIPDHIDPKSISARLDYGVLHLEGSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X063</accession>
    <name>A0A0R3X063_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6472</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X063"/>
    <dbReference type="WBParaSite" id="TTAC_0000648701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000648701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000648701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6230290at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000648701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42415" checksum="7D407886A43E4C36" modified="2016-01-20" version="1">MYNVHKMLTLDSNPLIRLEKRLNALKHTHNAGLARSTFLTENNFNVNRQLMESLILRLRSVDPKSKKSKRVASRVKVGSPKRMRPMPMKPQELFNPHYTSYTGFQSKLHTVKRMHPSEYCDTSDSTFLKDLKELPSLNPSEVETVLLKKDMSTRSSCQKGEPIFPPPPDPSCAITPRAVVTSAGKSSASNMQRIRKGSQTFNLTGPSPDKFTIPTTSCVPNFGQSMRPSGLSSTLPVSSCPYVDLRAKYDPDCYLSAPPNYEQFGLSGFSNDYSGFTPYNRSPNYAPWMSLGKYDHNISNRVAQGSASISPDGAPGYRNYSATAGPENSSGFATNLPFNSSFQSEDFMQGIPSYPPSIDPQQSAYGINLSSYTYPPPSTTSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0F2</accession>
    <name>A0A0R3X0F2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6593</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0F2"/>
    <dbReference type="STRING" id="6205.A0A0R3X0F2"/>
    <dbReference type="WBParaSite" id="TTAC_0000660801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000660801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000660801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002588">
        <property type="entry name" value="ATPase, AAA family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000660801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="599" mass="66630" checksum="9730E961CA4AB6C9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0X7</accession>
    <name>A0A0R3X0X7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6801</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eucestoda</taxon>
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        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020323">
        <property type="protein sequence ID" value="VDM31070.1"/>
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    <dbReference type="WBParaSite" id="TTAC_0000681601-mRNA-1">
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    <dbReference type="OrthoDB" id="5976022at2759"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000681601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23159" checksum="00A292F1F97A5925" modified="2016-01-20" version="1">MLHTSPLEEHHIIITTSTTTTLLLAALHAEEVVVVVISATHHIECVYWLLKSQSAEAQKVNGKACMLEILDTAGSEQFSSLQDLYIRNGQGFVLVYSVASLQSLLDLEAVHQQILRFKAKAPSRQSKTAKSTALPALPPIVLAGNKSDLTSVGHREVAKADGDAAARRWGCCAFVETSAKTGEGVMDVFREVVLQFLSLSSLSTLTSEKSLPSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Z8</accession>
    <name>A0A0R3X0Z8_HYDTA</name>
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        <submittedName>
            <fullName evidence="6">DUF5743 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6827</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020325">
        <property type="protein sequence ID" value="VDM31099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000684201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000684201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000684201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250330at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044041">
        <property type="entry name" value="DUF5743"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19014">
        <property type="entry name" value="DUF5743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5743" evidence="3">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000684201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="643" mass="73321" checksum="B8762214A3E537E2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X140</accession>
    <name>A0A0R3X140_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6873</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020328">
        <property type="protein sequence ID" value="VDM31152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X140"/>
    <dbReference type="STRING" id="6205.A0A0R3X140"/>
    <dbReference type="WBParaSite" id="TTAC_0000688801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000688801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000688801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133131" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="156"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="309"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="446"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="596"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="704"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="847"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="947"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="977"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000688801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141533" checksum="52D560D64BACB982" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1E1</accession>
    <name>A0A0R3X1E1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7000</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1E1"/>
    <dbReference type="STRING" id="6205.A0A0R3X1E1"/>
    <dbReference type="WBParaSite" id="TTAC_0000701501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="305"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="559"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="845" mass="95988" checksum="17FC01D2134C3C02" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2T0</accession>
    <name>A0A0R3X2T0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7602</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="UYWX01020387">
        <property type="protein sequence ID" value="VDM32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2T0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2T0"/>
    <dbReference type="WBParaSite" id="TTAC_0000761701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000761701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000761701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="333"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000761701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="50191" checksum="FB83AE68147A4C68" modified="2016-01-20" version="1">MSMKYKICGVGAGILGVPVCAVIASKCPEYSISVVDSDENIIKQWNNGPDYPISEVGLDDLLKQCSGKNLTISSDVDAYLAVADIILICVKTPAKSLGVGRGRAADLGSIEAISRQIVASGNSSAIVVVQSTVPIGATDLINSIFTANKMQSSNLVVVSNPQFVSEGSVIENLLHPDRVVLGGEMDPNSRKAVNVVSSIYERWVPKEKILTMSTKSAEVTKLVTNAFLAQRVSSINAISSVCEETAADVRQVADAVGRDTRVGRHFLDAGLGFGGNTLPADLHHLVYTCESLELPTVAAYWNAVLSVNDFQVSRFFRKITAHYCETLRGRRLALLGCSFKKGTPDVKNSPAVVICCRLLLEDATIAVYDPLAKKEFLVDAITDVLGQKPANIDNLIWCMTPMEAAENADGIIVCTDCDEFKSLDYNAIYQAMRKPASFFDGRLVAPHRELQAIGFRVEAIGVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Z5</accession>
    <name>A0A0R3X2Z5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7675</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020394">
        <property type="protein sequence ID" value="VDM32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Z5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Z5"/>
    <dbReference type="WBParaSite" id="TTAC_0000769001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000769001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000769001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="282"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000769001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47239" checksum="F4CA8CD6A02CED4A" modified="2016-01-20" version="1">MGKSHKESKRKKASDAEAETYVIQSEDTTPKLDTSNWPLLLKNVHLMNVRDCHFEPSDRGYSPLNRPLSEYIKHGVINLDKPSNPSSHEVVAWVKRALKVEKTGHSGTLDPKVTGCLIVCIDRSTRLVKSQQNAGKVYITIFRLHEGAPSLKRVQQACETLRGALFQRPPVISAVKRQLRIRTIFRSDLLEYDQEKRIGLIRLDCEAGTYVRTYCVHLGLMLGCGGVMEELRRIRSGILTEEDNMVTMHDVLDAQWVYENCHDESYLRRVIMPLEKLLIGHKRIMVKDSTVSALCFGAKLMLPGILRYDDNINIGDEIVLISTKGEAIALAIANVVTAAIATCDHGPVAKLKRVIMDRELYPRQWGLGPVATRRKLERAMLNQGTPGASEVEAKKDPPPKKRLRQASSSSSSSSSSSSTDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X391</accession>
    <name>A0A0R3X391_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate dehydrogenase, cytoplasmic</fullName>
            <ecNumber evidence="4">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS7786</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020405">
        <property type="protein sequence ID" value="VDM32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X391"/>
    <dbReference type="STRING" id="6205.A0A0R3X391"/>
    <dbReference type="WBParaSite" id="TTAC_0000780101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000780101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000780101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000014">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="15">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="16">
        <location>
            <begin position="157"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000780101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36526" checksum="08AA2566C059D793" modified="2016-01-20" version="1">MPGALKVLITGAAGQIAYNLSNMVANGNLFGKDQKIILHLLDIPEAKTVLEGVVMELQDCAFTVLEGIVPTHCLKEAFTDIDVALMVGAMPRKQGMERRDLLSSNVKIFKDQGEALEKYAKKSVKVLVVGNPANTNCLIMSKYAPSIPKENFTALSRLDHNRAIYQVAAKVGVPNECVKNVCIWGNHSNKQFPDLAHAVVTKGGKQHPAKEMINDEKWVKEVFTPCVQNRGAAVIGLRKLSSAASAAKAIVDQMHDWWFGTKEGEWVSMSVYSTGEHYGAPKDIYFSFPVTIKNGHYKVVDGLSMDEWSKGLFKITADELVDERDVALSSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3E0</accession>
    <name>A0A0R3X3E0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7843</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020412">
        <property type="protein sequence ID" value="VDM32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3E0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3E0"/>
    <dbReference type="WBParaSite" id="TTAC_0000785801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000785801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000785801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000320">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF50">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="5">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="6">
        <location>
            <begin position="266"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000785801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="52523" checksum="FD6E9617A2CA8E49" modified="2016-01-20" version="1">MRSILLLQTSTDPVIAVDFNPVDANSLVSIGKSHLAFWTLEGSNLTKKQGVFDKQEKPKFVLSMTFAENGDLITGDSNGNIFLWSRGSNKITQAVLGVHAGGIFALTFSKTGRLLSGGGRDSRIVEMDSSLNPTGVFIELSAWYGPVRTLITGPGDILIVGTTQGDILQGQLGSDFNPLVQSHGDEFWGLAAHPQSHHFLTGGRDGNVFLWDSLTRRLVWAENLSEEIICATFYPAVVTSIAPVSNHTETGGDENVGGGDLADSVPVVALGAASGRWIVLDAVLHQIIAAHHESSEPIQCLAYSPNGQFIALGGRDNSIYVYNVTARGTKYSRLGKCSGHSSFVLHLDWSEDSQYIRSVSGDYELLYWSVANCRQVASTSSMRDVRWASQHCTLGFDVAGIWASDSDGTDINAVCRSHSTRLLATADDFGQVNLFRYPTCQLKSEPRSYGGHSSHVTNVDFLFDDSRLISIGGADMAILQWEVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3V3</accession>
    <name>A0A0R3X3V3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8035</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020435">
        <property type="protein sequence ID" value="VDM32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000805001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000805001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000805001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266229at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000805001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22632" checksum="55CF1DB517A9716F" modified="2016-01-20" version="1">MSTFKLIALDETSSHSHGTHRRDTDFLLTNGNVYALKVDPPPRTELVRLQQIFAPLKPDHPIPEYKPRNRPYQETFNSPTPVIEIGGNGDCSRDSDEMSNYNGDSDLSTKGEAVATKLNDIIQRMETKLYSSGDDDDPCVHNPLLEEKETFKEDPSQSTYIKTSAKGAFNTLLIELVRVEHVSFTSSLTAATWFAQRRGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4Z7</accession>
    <name>A0A0R3X4Z7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8499</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the riboflavin transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020518">
        <property type="protein sequence ID" value="VDM33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4Z7"/>
    <dbReference type="STRING" id="6205.A0A0R3X4Z7"/>
    <dbReference type="WBParaSite" id="TTAC_0000851401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000851401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000851401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995836at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
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    </dbReference>
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    </dbReference>
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            <end position="275"/>
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            <begin position="375"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="448"/>
            <end position="470"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM33060.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000851401-mRNA-1"/>
        </source>
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</entry>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2016-03" db="UniProtKB">
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
            <dbReference type="EMBL" id="VDM33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000892301-mRNA-1"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020750">
        <property type="protein sequence ID" value="VDM34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Z6"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Z6"/>
    <dbReference type="WBParaSite" id="TTAC_0000930601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000930601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000930601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000930601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33428" checksum="DA421FBB68DFB3FF" modified="2016-01-20" version="1">MDSGVVKACNVEKSRSRVCSICLASEAKYTCPRCSVRTCSLRCCKAHKDATMCSGKRDVAAFVARKNYDYFAFLSDYRFLESLDRANENREKNIAEFCTIIKKRRKTQLKILNAARSLNINYRVSNGFLTRARLNRTHLTCDKPPVILWTLELCLLGPTSGASQSDEKPWSDRILRPIHILLHDCSCSSLLSDIWRSKVAELPSSELEALIVPQLATFPNVIMNPHLTNWILTLDKRFPYFYIECVDRQTKRVLKHEIFPSSTSLLELLTRDKYVVNEFPTIWVSHEELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7C5</accession>
    <name>A0A0R3X7C5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9437</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020818">
        <property type="protein sequence ID" value="VDM34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7C5"/>
    <dbReference type="WBParaSite" id="TTAC_0000945001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000945001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000945001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000945001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22962" checksum="816596B930FF067E" modified="2016-01-20" version="1">MTSSYPAAPRIQNFADGKGKSNSQPGSPISLYERSPERVTRQNQLLQPALLPRPSRASSEVNIAEIEETRASEICSKSENAFPPPEQVPREMKGLNSKRMNWVKLIRLQLNALHEKKTKGSNFGKTVGETETSEAEPYDASPTSRDDHRQSIAKDQTPSADPPSEMPQQLSVPLLIVSDAHNSSLLDTDHKGIAVGGDGKKRCVSIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7F8</accession>
    <name>A0A0R3X7F8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9468</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020833">
        <property type="protein sequence ID" value="VDM34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7F8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7F8"/>
    <dbReference type="WBParaSite" id="TTAC_0000948301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000948301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000948301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25246at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000948301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22596" checksum="9ED2C9AAB126E380" modified="2016-01-20" version="1">MFVQHPPHLQQQQQQQQGQGGDENAFGNSGGPSTDQSPLYPHGGRSYAAFGSQSDERVYATSSAVASDDTLFTSPASQFNFVRSWIAQHHHNHNQHHQQNDVNSAHSHQSEVGYQPAGGLQAYPPVGHQFGALIDGSGSGGANGFSQVPTAAASAARFGVFQASTGGTSTTTPVSSMTGYSGLFPRLERWCLMLMKLILLECSYTFFYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8B1</accession>
    <name>A0A0R3X8B1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021042">
        <property type="protein sequence ID" value="VDM34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8B1"/>
    <dbReference type="WBParaSite" id="TTAC_0000978601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000978601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000978601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270344at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000978601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="34003" checksum="2464C2F5B07D9270" modified="2016-01-20" version="1">MAAECAQVVTLADKQKSSGKSIPPPKSICQPFTLRLVLGVPIIKEENKIFNDLESLFSKYARIEALSANPLSDKIDVDLFWNHMQTGVNTVVKLLEDAVRETSTSKCLDPFAVVLLDFAWLNSQLGHHLAHICSGTPHTSLLAVSPPGKLGKMVNSSSKVICVGIRPLMTPQCARLPQLRDFLRACAALTGKPLPPDPAASTTASLTAASVTASGGAEGGVAGATVGSTPQYVPILPKPPTTVFVSPHANVDITPASTGYVVAAGGGTPGLISNSVCTLPFGNGLDSTPSILNGVPPDNTSQLYSASPSFLKYQCLFNYLLPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8V8</accession>
    <name>A0A0R3X8V8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9968</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021201">
        <property type="protein sequence ID" value="VDM34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8V8"/>
    <dbReference type="WBParaSite" id="TTAC_0000998301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000998301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000998301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000998301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22207" checksum="FB10EB588895F086" modified="2016-01-20" version="1">MMVVLQSLHARRVDLRFCHSPAIRRCSWDIVETLLHFVRGCVVPRDACGVLSGSESWRFAETQINGLTKLAADEDELTAPHRPSNAKVLYPIVSPMSSPFRAFASQGGFDDVLKSGCTVSSCTKRNVGGDDSSATDCSTWLRRFSTSSISSYLTRQSISMELAKSARLPAGLSFDGLGFSFCAKDSLLVEDIENEEAEDEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X906</accession>
    <name>A0A0R3X906_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DCB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10016</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021241">
        <property type="protein sequence ID" value="VDM34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X906"/>
    <dbReference type="WBParaSite" id="TTAC_0001003101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001003101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001003101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252495at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001003101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118960" checksum="19AF98DD6FC24139" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X960</accession>
    <name>A0A0R3X960_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021288">
        <property type="protein sequence ID" value="VDM35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X960"/>
    <dbReference type="STRING" id="6205.A0A0R3X960"/>
    <dbReference type="WBParaSite" id="TTAC_0001008501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001008501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001008501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="89"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001008501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35123" checksum="114D34AC68EEE171" modified="2016-01-20" version="1">MGRLRCSLLPEEALDNCILYRVLKSGTEAVITAFLPDAGEFGLEIYASDLERDGSSYFAIWQYLIISEVAASERGLPNLPTGYLGPAARFYELGLQVVSHPDPFIRAEAGELRIQLAYQPQRPLKMMAQLIFASNNVTEDYSQMVLQQMRMGQVYFVVRIPRLGFFKLQIYALPEGDRDDSLPGVYNYLIEASKATHRLRGQLMPFPQQFAHWRRSGCYLDAPTEGILGLDANGRLMTNPPAEVAFCLAVPSAHSVAVVVDDDWTYLEARGDRWEGIVPMRAHWGRQSRLSVCASYSQHDANFSTLLEYTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9S1</accession>
    <name>A0A0R3X9S1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10280</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021502">
        <property type="protein sequence ID" value="VDM35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9S1"/>
    <dbReference type="STRING" id="6205.A0A0R3X9S1"/>
    <dbReference type="WBParaSite" id="TTAC_0001029601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001029601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001029601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001029601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="32174" checksum="0C0712367967360C" modified="2016-01-20" version="1">MSGNPSRPVVHSDVPHGFVDILESLVGFVSRQCGFQYIEQPCLPLLTNLLISFFESLATKSLGYAEAASRTKIVLNDLVLAFVDFGFELSRIFEQSRHYPLPGFNGPTALGDPARGVVCKAVIGPSGAPIIPCTVSLRTDAVKSVGSGAASLPAAGGAAAVIAAPQTAPKAPAHLLLPPLPEPHTYLDSKVTRPPPAQNLASLRRQVIDQRRQMQLSLTSYVSLGQSVDHLFPGDRESFPILLPQPSSRPYVSALLAESLPESEEEVNDATKPTVQDPTEKAHSVDGAVSNFYLCKPTFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA52</accession>
    <name>A0A0R3XA52_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pan3_PK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10412</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021669">
        <property type="protein sequence ID" value="VDM35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA52"/>
    <dbReference type="STRING" id="6205.A0A0R3XA52"/>
    <dbReference type="WBParaSite" id="TTAC_0001042901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="4">
        <location>
            <begin position="471"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62042" checksum="3CAACD2F05034663" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAF5</accession>
    <name>A0A0R3XAF5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FoP_duplication domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021790">
        <property type="protein sequence ID" value="VDM35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAF5"/>
    <dbReference type="STRING" id="6205.A0A0R3XAF5"/>
    <dbReference type="WBParaSite" id="TTAC_0001053201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001053201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001053201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001053201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29022" checksum="C5EB77D77076E453" modified="2016-01-20" version="1">MEVENGVLTHYVNKSDLPLTSKTLQDRVQQRLKDIERRHRGEPGVGGGGEGSDGHWRGRGGFRGTGDRGFYPRGRSSGPRGVPRGSWRGSWRGDDGGEWRGGRRGNWYGNRDRYGGDRRGGGVDGGPDDFRKRPRRYDRSRSHSASRSRSRSPVSRSRRSRDSRSMSRSHSRSYSRSISRSPSPFPKKPISRARIKTPPLAPLTNRQSDSEEQMADVEQFVAQLQAKRQLEAEQAAAAAAAANTASDQPLIGPQIPGSASATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAS0</accession>
    <name>A0A0R3XAS0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021960">
        <property type="protein sequence ID" value="VDM35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAS0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAS0"/>
    <dbReference type="WBParaSite" id="TTAC_0001064701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001064701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001064701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001064701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="54" mass="5978" checksum="22632301A7B3E7C9" modified="2016-01-20" version="1">MSADGKSQLGAIRKEWSGLVQEFFTDADNFSVTFPHDLDSRAKMLVLCAAFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAW3</accession>
    <name>A0A0R3XAW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xpo1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10673</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022030">
        <property type="protein sequence ID" value="VDM35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAW3"/>
    <dbReference type="STRING" id="6205.A0A0R3XAW3"/>
    <dbReference type="WBParaSite" id="TTAC_0001069001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001069001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001069001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="76"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001069001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45016" checksum="11DEF5A7B3C1343A" modified="2016-01-20" version="1">MLTARCVTRFWDLLSPSAYIKVTENYKESDFKLSDLDYFCSSEQEATVILFGLKCLEHRFDNMVFRNSESNAVCLAVTQILVHLIKCEWPQNWPLMISELTSIGRVGLPQSLIVFDIFRRLSEDILFFPDVPVKRRRELCAVLSDNVPQIAHFALDSIFSAVKFHTSLEMDFSEDTISALRSALALLSVLFEWSNLRPLIEWRAPEHVLVTSEAVGSIQLLLLLLRLPKLRIEAADVLSVMLTKKQTDAITEKGKSAGNTHAYTYFFAFTDRIGQDPIDIILDISRLAFNTVEFDENACTFMRRWAEVISVLGIQVVENWSFFEVEGTVALKAFDLLIQANAFAAAHPSRVSQTSSGFEVLPPFSCLLLQQGLSLKQFYAPNVPHSYLYSLPICQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBT2</accession>
    <name>A0A0R3XBT2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2088 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10992</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022682">
        <property type="protein sequence ID" value="VDM35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBT2"/>
    <dbReference type="WBParaSite" id="TTAC_0001100901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001100901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001100901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001100901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8167" checksum="36F9A4619686BCCC" modified="2016-01-20" version="1">MPCHAVHRRGTFDFRTIIAPPNLYSDFWLRTIAFPYPNVAMPLPTPMTIVEHNCIVPLREQLKVFDQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC62</accession>
    <name>A0A0R3XC62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11122</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023010">
        <property type="protein sequence ID" value="VDM36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC62"/>
    <dbReference type="STRING" id="6205.A0A0R3XC62"/>
    <dbReference type="WBParaSite" id="TTAC_0001113901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001113901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001113901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001113901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="49399" checksum="B908E8D20194A30D" modified="2016-01-20" version="1">MFEVHVKTLDGESKTFQIDDDNIPIERQRLIFQGKVLVDDRKLKDCGVASNTIHLVPRPPPRTNADATASSSSPSGSQQPPLNPSNFMNFRQTMNSLFSAGPNFSPAGNTTSMQPDSGGNINIEVNASFGEMCNNHFQQLQRQTTQLLNALDGVSPSVSAISTPSINVDDQATVPAGASESGLSTSSSSSHQTSPLNFQRLADMLAEQRQLWQRLSPHMDRWEAMLRSEHELRTRTSDPGGGAVNPCVAAPDHDATLGTAGAADVELSPLPTDQEQEPMDTSEASTSIDWSQGFFNQVSALLHLHAHMLHLLSDFYVISTTSPTDQPTAGSTDVPAPSPSPAPAAEAQTGPIPAIRPHQSRSLVINEPDSSILYAHINIEPTVVTIARPVVSLSRADTEEPRGRRRSQSANPPSSAPSGVDEHTASDTMPFIVPRQLFEDEFLEFAGRELKCLESSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD72</accession>
    <name>A0A0R3XD72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11482</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024388">
        <property type="protein sequence ID" value="VDM36629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD72"/>
    <dbReference type="WBParaSite" id="TTAC_0001149901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001149901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001149901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001149901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7647" checksum="81843303FB462B94" modified="2016-01-20" version="1">MASKVVFGMAVMKTLKDEMLVNQRRCPLRNTPVTAAAPPINLLRIPTLCSVVDVDTGSRSPLLQPHYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDM2</accession>
    <name>A0A158RDM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS950</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000139">
        <property type="protein sequence ID" value="VDM17219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDM2"/>
    <dbReference type="STRING" id="6205.A0A158RDM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000094901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000094901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000094901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11765">
        <property type="entry name" value="SH3_Nck_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="449"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="568"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000094901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="689" mass="73744" checksum="4B391E4C61AF162E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDP0</accession>
    <name>A0A158RDP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1110</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000186">
        <property type="protein sequence ID" value="VDM17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDP0"/>
    <dbReference type="STRING" id="6205.A0A158RDP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000110901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000110901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000110901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000110901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="49887" checksum="0B723FBE7DFD6AF7" modified="2016-06-08" version="1">MDSSGRGTKKWLPCPARDAPSFRKMSQSDVHFYIGLSLALASTIFIGCSFIVKKIALRRLAATGTRAGMNELSDGGYQYLCDWVWWLGLILMGLGEAANFAGYTFAPASLVTPMGGLSVLVSAVFSSHFLGERLNFIGKIGCVVCICGSTMVVLHAPKEQEVQSLHELSIKVLDPGFLTYAIAVTIAGVVSIFVIAPKFGTRNPLVFVFISGSIGSLSVMACKGIGLGFKEAIEYGILAILRQWIFWFFLIGLIFCLTVQLNYLNRALDVFNTSIVTPLLYVFFTAFVLIASTILFKEGSSLSPTDYIGNAVGLVCIVSGIVLLTLFRDMNVSLSDLVKDFMGPVPTRVMHLSSDLSFKHRFSPTWCKRKSRGIPDEAYTLLSTSNECCSSNDSSHSSSPNHDMVEYPKLERHHQGVHQRTGSGASAFNFASVAVTTENYSTISETGSVNHSTIWTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE25</accession>
    <name>A0A158RE25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6509</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020306">
        <property type="protein sequence ID" value="VDM30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE25"/>
    <dbReference type="WBParaSite" id="TTAC_0000652401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000652401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000652401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056771">
        <property type="entry name" value="FH3_FHOD1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041387">
        <property type="entry name" value="FHOD1_GBD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24959">
        <property type="entry name" value="FH3_FHOD1-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18382">
        <property type="entry name" value="Formin_GBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="50"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="822"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000652401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="154891" checksum="E5B4670E12A44702" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REA0</accession>
    <name>A0A158REA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6930</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP206 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family. PCD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020333">
        <property type="protein sequence ID" value="VDM31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REA0"/>
    <dbReference type="STRING" id="6205.A0A158REA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000694501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000694501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000694501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000059">
        <property type="entry name" value="NUDIX_hydrolase_NudL_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12018">
        <property type="entry name" value="FAP206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01293">
        <property type="entry name" value="NUDIX_COA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="667"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000694501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115513" checksum="CD823D1F71057099" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RED1</accession>
    <name>A0A158RED1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7077</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <lineage>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
    </reference>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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            <end position="402"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000814401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1750" mass="189291" checksum="23708084FAF52494" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EUB1</accession>
    <name>A0A3P7EUB1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007438">
        <property type="protein sequence ID" value="VDM26941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EUB1"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="104" mass="11207" checksum="B495A335E580340E" modified="2019-02-13" version="1">MGRLSVWFAPPKAGPPPGEGVTSTEARREGEGGWEVMYGLAHKPSRLECRSLGQPSPQWTWTGPAIRKSVDPVSAGEVVEADGLALLYMLSGFKQTPADQINAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F068</accession>
    <name>A0A3P7F068_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001933">
        <property type="protein sequence ID" value="VDM21959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F068"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="3">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="210" mass="23750" checksum="6C7104EDDF7AF3FC" modified="2019-02-13" version="1">MQLAWEVVEVAKKLFMRHQDADHQLKASDCLEKLAEIGQEIGNYQQAISDLLECLKLRLEHAPDNDRLIAETHFQLAISYSQTGNASSADASFCHALKRLKDYRSKLELQLSEMNGENDGNKSEVTHLQVQIDEIVGLISEVSERRKECSDTVLKVEEPPAKSIRSDVHVDDITHLIKRKRPNSDASFCEDTKKMKIEGSSREFSPNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F879</accession>
    <name>A0A3P7F879_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Cytoplasmic vesicle</location>
            <location evidence="6 7">COPI-coated vesicle membrane</location>
            <topology evidence="6 7">Peripheral membrane protein</topology>
            <orientation evidence="6 7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Golgi apparatus membrane</location>
            <topology evidence="6 7">Peripheral membrane protein</topology>
            <orientation evidence="6 7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004644">
        <property type="protein sequence ID" value="VDM25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F879"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="264" mass="29434" checksum="45E03D8C17161FD4" modified="2019-02-13" version="1">MVSRQFVEMSKSRIEGLIATFPKLADPGKQHTFAETDSVRYVYQPLEKLYVLLITTKASNILEDLETLRLFARIPEYARGLEASDVVENAFQIIFAFDEIVALGYRESVTLSQIRTFTEMDSHEEKMFNAVRENQMQEARELSKRKARELELARHAAAKQGLPLNSIYNSFSSVRSADAFASEPSVEPPSDDQPGVPLLSRENWGSSTSESSARRGMQLGSRGGHIKAEMDRLTDMIRGEVPPVVSDAANVDTPTKPATTTMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F945</accession>
    <name>A0A3P7F945_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004672">
        <property type="protein sequence ID" value="VDM25117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F945"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="483" mass="53165" checksum="37F79E98C3FF77B5" modified="2019-02-13" version="1">MSASEVRSHRTWVQLEAAGVTLHSAESMRSRFMHSIIHHLGEVLHSTSEGRRKYGHVSFVNGLYQAFVAESNGLRAATVSSCEEESSNILSDPSYFTSDNSVHDGDQNDLSLGSLPRPSLQEQSKLIDCGDTQSQKDEADQCNASAEMCSSFNSLQKTLTERSPSGRLTRRLSLSLNNVLPRVRYPRSRCIFSRSQSASTRTLRSLVNKAHEAISGDTPDATTNGHSVQPLSRPLTTKKKSGFNSRDSGPESLTLLNVNSKVRHKAALERPCLAKSFRQLAPKLTKKSSILLSSTASSQQESMGMQLDSTFAKPVRYVRSAGESPSTSIDNQPTTSLDDGFKRRSKSLCCKNFEMVDLDSLHSSAKVHNLYPSKLSSEGSASIEVIPDTLSAISSNHSAHTNDIQTHSDAPCSSLLHNPDRLNNTSPKVSDVAFLKYFTSYAITTEIHFLLVILKQLLAEFPLIARLSIITHFRVSHQPEKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F9V2</accession>
    <name>A0A3P7F9V2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020474">
        <property type="protein sequence ID" value="VDM32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F9V2"/>
    <dbReference type="OrthoDB" id="10049614at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19699">
        <property type="entry name" value="bHLH_TS_dMYOD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="611"/>
        </location>
    </feature>
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            <end position="50"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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        </location>
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        </location>
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            <end position="296"/>
        </location>
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            <end position="330"/>
        </location>
    </feature>
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        </location>
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            <end position="603"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="611" mass="65843" checksum="6D272EA807AD465F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FF13</accession>
    <name>A0A3P7FF13_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020322">
        <property type="protein sequence ID" value="VDM31036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FF13"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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        <property type="entry name" value="RIC3_N"/>
    </dbReference>
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        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="33"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="318" mass="35506" checksum="29F4F770133A4894" modified="2019-02-13" version="1">MLQINGFMTAGMSHRRAVEIIQAGGNMIRLGVRRSFPPPTGELKNPAVPSPLSPPPLSFQPFGPMPPAPSPGPVVPPPPNPHSPQFFTPLPVHKPSIASRPLLSSAPNARLAKLPVFVDGEQEHKHAQQCSTTLKKRDRNPGIVAAILPFYAFGIFVYFVYTIVKLLNNRWKFGPKKKEKHLKDYYHNFHYIPGKEKFKMDSNSSEDECVNGSLRKIETSYKYSFQFLDELGWSRNTEGSKTTPNVYRSVSDDTEITRLRIRLEQMECEMTRLLEAVSNSATFLAQTQATGNESGTTNGQSADNHSDDSETLYSAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGX9</accession>
    <name>A0A3P7FGX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021452">
        <property type="protein sequence ID" value="VDM35211.1"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="157" mass="16623" checksum="F85C9A06E84AAC7B" modified="2019-02-13" version="1">MYILSCHLFSTTSTPPLSPLLSSPLTPQLLHTPQSKNSVASVHRVVPSSPSDNAVTVVSDNDDDNDDRDDDESDDNGVEVNPNLEGGKCLHPTSSTSSRPLTHIGGKVVEQATLQXXXXXXXXXXXXXXXXXXXXXXXXPLPVVNPSTAAATTIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4K4</accession>
    <name>A0A3P7G4K4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023002">
        <property type="protein sequence ID" value="VDM36099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="154" mass="17801" checksum="8FA675F75CF47982" modified="2019-02-13" version="1">MDEKEGVMNEVEIMCRLRHPRLIQLYDVFIQSDRITLIMELITGGELFERVIDDNFDLDEAICEKFMRQILQGVEYIHSQHVIHLDLKPENILCLSRTGFKIKIIDFGLAREVTNGDVRVMFGTPEFVAPEVISFDPVTYATDMWSVGVVCYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G524</accession>
    <name>A0A3P7G524_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023578">
        <property type="protein sequence ID" value="VDM36289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G524"/>
    <dbReference type="OrthoDB" id="6255582at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="206" mass="21252" checksum="2BF2BA3F0C801BF6" modified="2019-02-13" version="1">MFPNDLQAASSGLNVALFPISDWPDIAGDGGSENSTKVSSAPFVVNAPSASFSANMELSHSAGGNASRLQVFPPSHLPSSSTTTESAISSSNAMLLFGADVKCQTSLTEPSTVPTVIGSAQWSTPEKSLTQWLPSQFPSEQATFGTDPFDLDWAERATALAKGQLAACFPPSSTTSLAHLPAAPPPQPSGAAVCTNPFLAVPSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GVR3</accession>
    <name>A0A3P7GVR3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydropyrimidine dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01005817">
        <property type="protein sequence ID" value="VDM25972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GVR3"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="93"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="446" mass="47892" checksum="6C845D4B4352E536" modified="2019-02-13" version="1">MDDVDVLSAMKGVKLAPSGFSAGLPVIDPKTMRTNLPDVWCGGDLTGFAHTSVEATNDGKTAAWSIHSTLLGEPDIPMTLPRFTTPIDAVDVSVDVCGVKFENPFGLASAPPTTSSAMIRRAFEAGWGFAVTKTFGLDKDLVTNVSPRIVRGPTGGHLYGPDQSGFCNIELISEKTAAYWIQSIKELKRDFPEKRVIASIMAKFDEADWRELTERAVAAGPDALELNLSCPHGMGERGMGMACGQDPRLVHDICKWVKSAAGPGMPVFAKLTPNVSDILDIARAAQEGGADGVTAINTVSGIMHFDSDSSPWPRIGKERRTTYGGLSGNVVRPMALRAVSWIAKKMPGFPILATGGIDSAEAGMQFLQAGASILQVSSAIQNQDFTIIEDMVTGLKAALYLDGREARICGNMGKGEREHRESAWLVEMEVEELMKVGPVVWNLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GXD7</accession>
    <name>A0A3P7GXD7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008426">
        <property type="protein sequence ID" value="VDM27398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GXD7"/>
    <dbReference type="OrthoDB" id="2333377at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19893" checksum="2B070DC1C0F4570A" modified="2019-02-13" version="1">MRTRVPFSSVYGVIQFLALRSDYPSKSLSEFVRVKHFHLILNYLRDGSVPLPDNRQDLEELLIETRFYCLEGLRRICEEKLEKLVAETQEKPNAASIYIVKYPKVTKAIFASTKKVILLLFVSLISRFWECFEFGVCTVLGVCKTYKPVIYFLYFMDVTFSSVHLLDIVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GYU0</accession>
    <name>A0A3P7GYU0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007822">
        <property type="protein sequence ID" value="VDM27145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GYU0"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="130" mass="14367" checksum="183BC27185E13A20" modified="2019-02-13" version="1">MPPSIDIRLTQIPDNVAKQPSSSSRVSLPSTVLLPFGSVLVPSTSSSSYPVTAKYPDEASTTTTPQSPPPPPLGVNPSMLMSISTIIDENNMEMAESNLPEGWDERVDQNGRTYYVDHIHKRTQWDRPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H0M9</accession>
    <name>A0A3P7H0M9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009338">
        <property type="protein sequence ID" value="VDM27795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H0M9"/>
    <dbReference type="OrthoDB" id="6132489at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="112" mass="12619" checksum="98687275C2F6C619" modified="2019-02-13" version="1">MLTDLSGCQASLVFALVDQNFGGILLEGLNSRPTEFTNLVLLSATRQASATQTEQTVVERPVSEFFYPRHHAYRLGHYELYGVEDLLTYVVENLPLSQMLVGDIEKVRIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H1T6</accession>
    <name>A0A3P7H1T6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peripheral subunit-binding (PSBD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01010054">
        <property type="protein sequence ID" value="VDM28112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H1T6"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="3">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM28112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="245" mass="26176" checksum="74539F3028E20AE1" modified="2019-02-13" version="1">MGGGGDGGGAVPQIESSPPPASTSTPAPASKKPPIGPAVRLLLSSYGISSDQITGTGPNGIVLKEDVMAYVKSKGLQKIPQEASKIPSKGAVTGSATAPSRVSVVSTSSYVDIPVSEMSEFSAKRLIESKTTIPHAYTRITFSADRLFALQKAINRAQLVDFKISINDLILKACAYALRVGLYRLFRHRSRCLNCPVPSVVCEWCYLSYFSCSLLSLTFTASILCCKSILATHFDFLHGKARTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HLV9</accession>
    <name>A0A3P7HLV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023742">
        <property type="protein sequence ID" value="VDM36328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HLV9"/>
    <dbReference type="OrthoDB" id="10495892at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="64" mass="7646" checksum="5A5AD63838A7FEF7" modified="2019-02-13" version="1">MTDSYQYLVEDARKLRDFYTKGDVKDELYRRFLGQAFVVATDARVLFQSFQQCRQAHFLLTAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHW0</accession>
    <name>A0A0R3WHW0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">3HCDH_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS150</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHW0"/>
    <dbReference type="STRING" id="6205.A0A0R3WHW0"/>
    <dbReference type="WBParaSite" id="TTAC_0000014901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000014901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000014901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM15986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000014901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="33963" checksum="D8C12A07160C0734" modified="2016-01-20" version="1">MALRVGALYGAFTLKRLLSNVTVVGCGLMGSGIAAICASSGYNVKVLVGNDDQLKKSEDSVLRVLHGSSKSRSEDFVEAVATRIILTTDVNNALSDSEMVIEAVTEDLKTKCSLFQSLEHFAPSSCVFASNTSSLPINEIVKGFSRKEFFGGLHFFNPVQKMKLVEITRCSHTSGDTLKVCTLAAFAESLGKTVVHCKDTPGFIVNRLLVPYLLEAIEMWERRDASLNNIDMAMRLGAGHPMGPFELADHVGLDTLLRIIVHWVERHPEERAFRLNTTVRQLVAQGRLGKKCGHGFFMYDQRGRIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIB9</accession>
    <name>A0A0R3WIB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SLIT-ROBO Rho GTPase-activating protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS337</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000042601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36160" checksum="088CB23FC0016CAC" modified="2016-01-20" version="1">MRRLVYAIPGSNASFLFLFSTTWKPSKPPESNPKKKMIREAKSALKNLCPTSVAVRIPSGRNRRYAFIEFKTPAEAETAAKEVTGRVMNGKSIRAIVCSQKPTRTEADWQSPMERGLDAFDLTTLYVSCLPRSTERTILAQIFRTAHKIKYETLPDGTSKGFCVLKYQTRELAQKAFMERHDTLLKGTPIYVNFLIKSKAKLDGDEVMKREGVLHRELKRKAPEEDEVVVMPAKKRCCGNMDPEQVGVVDDSTVQARKIATKNKAEKGVHVTLPSKLNNRDPSFSIKYSMGPKSKKPKLQPYQLSKKSDNRIKKLRRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK18</accession>
    <name>A0A0R3WK18_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1046</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000164">
        <property type="protein sequence ID" value="VDM17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK18"/>
    <dbReference type="STRING" id="6205.A0A0R3WK18"/>
    <dbReference type="WBParaSite" id="TTAC_0000104501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000104501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000104501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="5">
        <location>
            <begin position="54"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="373"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000104501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62543" checksum="DE107FBDD80EAE45" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKE2</accession>
    <name>A0A0R3WKE2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Delta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1181</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000205">
        <property type="protein sequence ID" value="VDM17588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKE2"/>
    <dbReference type="STRING" id="6205.A0A0R3WKE2"/>
    <dbReference type="WBParaSite" id="TTAC_0000118001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000118001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000118001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5953235at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000118001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="74789" checksum="E57C9BE2ABC48EA0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKJ6</accession>
    <name>A0A0R3WKJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000231">
        <property type="protein sequence ID" value="VDM17679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKJ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WKJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000123901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000123901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000123901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033291at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000123901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56232" checksum="1493D9EE9068020F" modified="2016-01-20" version="1">MSLIDSRRSSTTSGKIRRIFHSSQSQIGHRKQSSPTIASHALPGLGRELSISEVGQLAGTTGRYLRIFCERVCPSAKFKTVFVQNDYTVSECIEKVVIQLSSEGDIVTSQVDLFEVIGRLPANSKAINESGTVNDPGEVFSELNSRPLPPEEKILNVFSLMAPAPGLCRRLELRKQLHPSSVSFPARIRPRIQNTVDSTVNSSRLMAPQCPFLLLIKGSRPECDPLVHSFSDICRGKVSEITMGTSAYNDIRLYLSPEAKISRETVNLNGDHYNDFKSPIRFIAKNHPASTKSKAIWLCIYSTYNFIQPEYPITVILNWETLTDSNNFPINKSLEPGDIIRIETSNLVYVFIFKDSQTVPEHKLPLGFFTLPQLPSVGGKPPTGQNGNRSAARTARIDALVRKTSSLSSHSAGGSSFLPTFSSVGVVVGNLFPRTPPKSGDSNWSEMGGILPDVGVAAGCFAHLLRSVVKHGLGTNGQNYVKYINEDDLFREINQALSRELEKLNRVSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL41</accession>
    <name>A0A0R3WL41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lachesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000325">
        <property type="protein sequence ID" value="VDM18044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL41"/>
    <dbReference type="STRING" id="6205.A0A0R3WL41"/>
    <dbReference type="WBParaSite" id="TTAC_0000147501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000147501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000147501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972932at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF33">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="235"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000147501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41260" checksum="64A9DB1F4BD85A17" modified="2016-01-20" version="1">MVIYCFYFPQPLELVVDSINIEVVQEKNTGYLNCTMVLDESQMNQASWYYGEKQISIGSKLLEPVRIGLYGMEKYQARFFPGRPDFAPNMPGMDIDRLQTYQLEVRFADITDNGMYRCVLEIKSLPRRLWPEAYGRLVVTQAPIILPGLASKIVDEGDSLTWVCQAQGSAQPRVSWTRANGRPLNLPGSPQRIYNETLHIPRVNRFDRGIYRCHAANNVYGSTEYDVMLEVNYKPQIRLARYKGAYGQKSDSNYDVIMECIVNGYPDPDLLWFKGVYDPKLNNIPLYDSAKYELEKTRSYGAVGTNVTDVISLLKVKNIRESDYGNYTCMAANRYGMDMTVTYIFCKSFTLLFCCYKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL66</accession>
    <name>A0A0R3WL66_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1489</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01000342">
        <property type="protein sequence ID" value="VDM18093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL66"/>
    <dbReference type="STRING" id="6205.A0A0R3WL66"/>
    <dbReference type="WBParaSite" id="TTAC_0000150201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000150201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000150201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="214"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM18093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000150201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52567" checksum="5085CF8B7300088C" modified="2016-01-20" version="1">MEPSDSEIYDEVKKILEPLNLRIEDYASIRDKILDAMVRGLKLKTRDTSSIKMFPSFVTKFPSGEEKGQFLALDLGGTNYRVLLVTLAGDGQHPKIDERTYAIPQKNMVGTSKELFGYIASTLQNFLKRYGLEDKSLPLGFTFSFPCEQHALDKSVIVRWTKGFNVKDAIHSDVAKLLQTATDDIGLKVKCVAVVNDTVGTLASCALEDARCAIGLIVGTGTNAAYIEKIEASEFMQKMEIENHINRPKEEDSVIINLEWGAFGEKGELQPYLTDFDIELDHNSLHPGKQIYEKMVSGMYLGELVRIILMHLVKRGLLFRGEMPDQLLHQGGFLTKMITETERDPPHLFYSTHSVLTEDLKLPIVDPLDDRVVRLACESVSKRAAYLAGAGISALMHKLNRPQITVGIDGSLYKFHPRFRERMTDIIDKLKPDFVKFRLRLSEDGSGKGAAAIAAAATRPSKQVVEFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLG4</accession>
    <name>A0A0R3WLG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1589</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000390">
        <property type="protein sequence ID" value="VDM18252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLG4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000160201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000160201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000160201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF106">
        <property type="entry name" value="IP06960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="57"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000160201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20997" checksum="800C468F438CE969" modified="2016-01-20" version="1">MWYPSDLGAISTGNLLLTVLTVLAFVCIAIGIACYVTFSSNKRSDPEKLPTMRKRDFTIQELSQFNGNGPDGRILIAVNGNVFDVTNNGKDFYGKDGPYAIFAGRDASRSLTMFTTDIPPSNEEYDDLSDLTSEQMKSLKEWELQFRERYPLVGKLLSPSEPHHLYESADNEDLSQVDAVNGSAKPKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMI3</accession>
    <name>A0A0R3WMI3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AT-hook motif nuclear-localized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000638">
        <property type="protein sequence ID" value="VDM18698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMI3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMI3"/>
    <dbReference type="WBParaSite" id="TTAC_0000197101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000197101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000197101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10498215at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000197101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17739" checksum="0AEBCF46B0757949" modified="2016-01-20" version="1">MRRRSGASPQVTDLRRRLSSASSTTTNTQNKSRTLGPRPVSPATGAEQLAFNVIFSGVDELPKTLPRTRSRQHSSSGYATPNTLTGYSDGNNWDNRSMVSGVSVGSVTSIYSEREESFTHGIIITGELSFSIDYDDKSSSLRIFVKQAREVAVADKKTNNSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMX2</accession>
    <name>A0A0R3WMX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000753">
        <property type="protein sequence ID" value="VDM18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMX2"/>
    <dbReference type="STRING" id="6205.A0A0R3WMX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000211001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000211001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000211001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000211001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28897" checksum="EA56B030651ED1F9" modified="2016-01-20" version="1">MVTTYQQIADIKSQRDSNMRTEVFNPIKDTTLKELGNIQKLRKSVADAQNELNAAEKNREKDGNPQATARRDLAFRSHSEAMERLKRALIDFRQDEPKRITFLQASAEAQLEYHKSAVEAFTNLVSELKTIRLIVHFICRTYSRGNSADSLPGMAFDTNINGDGGYYDKPQTDFGYVATVGRSTPPTECKYLLGPFLVCAALHSSGVYRFKIGRTDSNLRCGVHEVDDQWYYGEKDGRRGHFPVEFVQVLQDNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN29</accession>
    <name>A0A0R3WN29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2154</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000805">
        <property type="protein sequence ID" value="VDM19052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN29"/>
    <dbReference type="STRING" id="6205.A0A0R3WN29"/>
    <dbReference type="WBParaSite" id="TTAC_0000216701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000216701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000216701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262482at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="110"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000216701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="600" mass="68140" checksum="0325B6375D9C49F1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNC6</accession>
    <name>A0A0R3WNC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2251</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000893">
        <property type="protein sequence ID" value="VDM19371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNC6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNC6"/>
    <dbReference type="WBParaSite" id="TTAC_0000226401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000226401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000226401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="Beta-prop_ACSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="2">
        <location>
            <begin position="607"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000226401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="963" mass="105736" checksum="97E0B46D00CED5CD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNG1</accession>
    <name>A0A0R3WNG1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2286</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000927">
        <property type="protein sequence ID" value="VDM19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNG1"/>
    <dbReference type="STRING" id="6205.A0A0R3WNG1"/>
    <dbReference type="WBParaSite" id="TTAC_0000229901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000229901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000229901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9675250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047734">
        <property type="term" value="F:CDP-glycerol diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16509">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16509:SF1">
        <property type="entry name" value="MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000229901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45477" checksum="B1DDEE742EE8EC28" modified="2016-01-20" version="1">MDFCGSKTEILAEHENCFQEVVPECPMGKVAPNFPCPGPQRHRLNYYGEYETTCWSLNNPLCRLGAFSDLRFSKHVELPNFSLNVLDKTLLSLSYENTDAIIQLGNIIDTRYVNTEAEVEDLIAHLAHVFNKTYRKVCHVIGDLDSAVVVGPQWRLVVLDGYEQLMVEPRNTAEPPTPYNSETTGHGFLMHFNIRDPDDKKCSMHITEATKPVGWSRELMTVGEFMTVEERGQVPRVRLIMSQRQLKWLNATIQEALHCNENIIVACHAPLHPLMVQDRSTLVANWREILKLLMHCGVVRCCLMGQPLSMDYESNKCNPTYHHDHGILYYTLPPVNDTAERNRQVSAHILIDLGRDFVRIRGEKVGLRPEHQQYGVVHSFRPRTKVSYKDRDYSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNI6</accession>
    <name>A0A0R3WNI6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNase_PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2311</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000951">
        <property type="protein sequence ID" value="VDM19599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNI6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNI6"/>
    <dbReference type="WBParaSite" id="TTAC_0000232401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000232401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000232401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000232401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25370" checksum="E4956D94EE98FCF6" modified="2016-01-20" version="1">MEVSNLFVELNPDCNATGSASWAFGDAHVMASVYGPKEASMANELTHRAYIDVSVLPVSGLHTPFESEMEFYLQNFLERLIDVKVYPRNQFGVRIQIISGLSGHPTTMAACVNALSLALLPTSIPLHASVVAVCSSEIDPGLRPVMVALDVSNLASRMPSDAKRLKKESENIHCAPDVFGVYCGRPGSAFTADEATIQSSQLLALTTDLDPQSHLCSRARDLFDVMVNQLTAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP35</accession>
    <name>A0A0R3WP35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001158">
        <property type="protein sequence ID" value="VDM20285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP35"/>
    <dbReference type="STRING" id="6205.A0A0R3WP35"/>
    <dbReference type="WBParaSite" id="TTAC_0000252301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="26670" checksum="AA3FDDAA5C4BC1A2" modified="2016-01-20" version="1">MGSRELFVDGNNLEAEGATALLTQLAEAAYLEGKERERLKAERMVAAAAQSQAARKRIDLDGPLTESETHAGESPSTIADLNPEIVSINANTQENAANTNVSASRKKRTLGKGTNKKKAAKMPPCGPQITHIHMAENSINSIGRGGSFAPARCMQLLKTQATIITNTLYLIACSIIAYSKDLQEVDIFGNDIGQVAGRIVLEGILARKDNNLPRIGVRVTHLINQDTYDMIRKLAPKPKGKKKRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPM7</accession>
    <name>A0A0R3WPM7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS2702</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001405">
        <property type="protein sequence ID" value="VDM20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WPM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000271701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000271701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000271701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000107">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="17">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="17">
        <location>
            <begin position="213"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000271701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50747" checksum="B369CB8EE53D9CA7" modified="2016-01-20" version="1">MDNPTPCSLSRHGHLCKFPYVCHDFRPNMTKAAIAQRRAIMANMSADPYAFTGFIKLPERWPGPNYGITNFDNLAASMLTVFQCVTMEGWTNVLYWMNDSQGMEWPFLYFVSLIIIGSFFVMNLVLGVLSGEFSKEREKAKKRGKYQKAREQMQFAEDVQGYLDWIGAAEDLSDDEDNANRLDVKEKRKHSSRRSRRLNRRCRRSCRRMVKSQTFYWTVIVLVFLNTGVLTSEHYGQPKWLDVFQSDANVVFVVLFTIEMLLKMYSLGVRCYFDYMFNRFDCFVVICSILEIVFIMTKLMPPLGVSVFRCARLLRVFKVTRYWNSLRNLVGSLLASMRSIASLLVLLFLFIVIFALLGMQIFGGRFNFLSLRKPRSNFDNFYQALTTVFQILTGEDWNEAMYMGIKSYSAQPFGSLVCLYYVFLFICGNCILCCRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPT9</accession>
    <name>A0A0R3WPT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA_pol_B_exo1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001485">
        <property type="protein sequence ID" value="VDM21105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPT9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000277901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000277901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000277901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="1">
        <location>
            <begin position="364"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000277901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="624" mass="69533" checksum="7A9E9A0C2179D087" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ40</accession>
    <name>A0A0R3WQ40_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2865</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001606">
        <property type="protein sequence ID" value="VDM21354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ40"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ40"/>
    <dbReference type="WBParaSite" id="TTAC_0000288001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000288001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000288001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267284at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000288001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17430" checksum="6485B75E7CC22A1E" modified="2016-01-20" version="1">MESGDSEVPPNVEMLHPGGQINQRTHRYPHCVVWTPLPIITWLFPLIGHVGITNSKGVIYDFAGPYYISEDNMAFGWPTRYLQLDMESVGGAENWDRAVHEANTEFKGRMHNICCNNCYCHVALALNEMGYGGSTTWNMYSFGLMMAFRSKFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ75</accession>
    <name>A0A0R3WQ75_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin subfamily A conserved domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2900</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001654">
        <property type="protein sequence ID" value="VDM21469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ75"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ75"/>
    <dbReference type="WBParaSite" id="TTAC_0000291501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000291501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000291501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2286360at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="792"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000291501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121680" checksum="9B8D72A8B25DB480" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQN2</accession>
    <name>A0A0R3WQN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3057</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001860">
        <property type="protein sequence ID" value="VDM21853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WQN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000307201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000307201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000307201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000307201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41086" checksum="D6A8CC37A2CADE75" modified="2016-01-20" version="1">MAHEDADPFEFRYSDAKDKIMLFVGVIFALAVGCSFPVNLVIFSSVINLLTSPLPVNLDEMRIMVGWFCLLGVVTLILAFIEIFNFSYSARRQSRRIRLKLFKQILRQDVPWFDRQSLGDLITKLTSNIEQIETGIGERLGRFIQNAAMFISCYVCAFINNWKIALVGLSAAPLIVLAFSVMGLTMSNFALKEQRAYSKANNVASEVFNAIKTVFAFIGQEKEKQRYSSQLGAAAKVSFLKNVMLGFGIGLIGGSIFAAAGLTFWFGVKEHMDGQPNTESGTIVSVVLAFIVGSIALGLVLPEFSYFTRATAAASSTYWIIERVPKIDKDASGLQLDNMHGSIEFRNVSFAYPMRPDVVVSVFENILTPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQQ6</accession>
    <name>A0A0R3WQQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001895">
        <property type="protein sequence ID" value="VDM21916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQQ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000309601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000309601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000309601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288582at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000309601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19460" checksum="CB11A17FF1E51578" modified="2016-01-20" version="1">MPMQVPPGHLVQQIVDEDGVLTHVILSPIAPYSSQKAVSPVPTGGSAPTLTRSSPPSARSPLSGSAPRLPAWPSRLCATGGVNVIISPKTSPGLAVAGPTWPTHTRPVDMALVQPPPLHHQQLQHKPTNDFLSLPNETVTSLPEQRWKVKQERQVGAKRENLEEVGPLQPSKSLQTFLWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR57</accession>
    <name>A0A0R3WR57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3232</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002100">
        <property type="protein sequence ID" value="VDM22208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR57"/>
    <dbReference type="STRING" id="6205.A0A0R3WR57"/>
    <dbReference type="WBParaSite" id="TTAC_0000324701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000324701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000324701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000324701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34637" checksum="9D8AE588CB4602CA" modified="2016-01-20" version="1">MTSSSEIGALFEEVDSDHNGFITRENLADYVKKNHLPPETVNVSNNHLFMRKKNVNKLFVNLEDCNHLLTKMLPFKAVVPRLCVCAQCGVISRGSGTYTCKMSMPVSQELAKMFEAIDTNFNGYITREELEEYAKKTGQPESMVDDWFKWFDFGNTGQITYEDMCETLAIGMTKAYSEKVEKKRELIQKGKIAPPKDMPREYAAPQPKPDWLEGVKVLYTGRSEAGLLEDVVGVVKSSNIKDFEKESTFARYLKETMEKKWGRHWQVIVSQSTFGCAVGHEENYFVHFQYGPHLFILYRTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRF4</accession>
    <name>A0A0R3WRF4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3329</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002256">
        <property type="protein sequence ID" value="VDM22407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRF4"/>
    <dbReference type="STRING" id="6205.A0A0R3WRF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000334401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000334401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000334401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF515">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000334401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24240" checksum="E969819C0AC313C9" modified="2016-01-20" version="1">MALTCGEQCLRILLVVCNLFVFLFGCICTGFAAYTLAKVKEYTNDQWAIVIPAFILALVLLILLLGFLGCCGAWKLNSCCLKTYAAIITVLIIIEVICGILILVYHDKGKDFIVRFLKECIRDAEIPGNIEMEDMMRNLQEKFECCGAAGPMDWSNPTKYCDRHGGLISNVSSIFKRGCADAIYEYLRSHAIVVGVTAIVLSIIEIGAVFAACCLAGKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRN5</accession>
    <name>A0A0R3WRN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002390">
        <property type="protein sequence ID" value="VDM22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000342501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000342501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000342501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000342501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15062" checksum="85E2587AA7F9E90A" modified="2016-01-20" version="1">MRSLEDQCSPSLADIAIKSILDTNPVLKFAMTGFLDVSDTTGDVFYDVGPLKASDRLKSLQCYAKEPVNEGRPIWLLNITEVWTEEPSGYILPYDPELRKDVAGKQNKFVVDLMAQPGVMYNMDTKEAFQYCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRW2</accession>
    <name>A0A0R3WRW2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3487</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01002519">
        <property type="protein sequence ID" value="VDM22733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRW2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRW2"/>
    <dbReference type="WBParaSite" id="TTAC_0000350201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000350201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000350201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000350201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8421" checksum="9D041D415F296E00" modified="2016-01-20" version="1">MVNWRFSRGTEEQMEAFMAGFSDVFPLQWLQYFDERELELDQHGLMYIEVIDLAQSRWKLGGSSLSPKSCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS43</accession>
    <name>A0A0R3WS43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3568</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002647">
        <property type="protein sequence ID" value="VDM22888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS43"/>
    <dbReference type="WBParaSite" id="TTAC_0000358301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000358301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000358301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264252at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000358301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60147" checksum="B72168405CCC3E32" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS89</accession>
    <name>A0A0R3WS89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002737">
        <property type="protein sequence ID" value="VDM22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS89"/>
    <dbReference type="STRING" id="6205.A0A0R3WS89"/>
    <dbReference type="WBParaSite" id="TTAC_0000362901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000362901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000362901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000362901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="34243" checksum="2AD1EE97CEE93501" modified="2016-01-20" version="1">MFGNNWQTQEDYQNSQPPVESVCLLGCESWPDLSPTSDRYALRIFTPLLKQALPLSSALRADSSTVDGGGMGDGDSMSLTTRLKRRASLLSLTSLGGLNAVCGRAVSRASGLLNELILRLPDEAHYVEWAAAVRLAGSLSIGCSGAATPETVRRLYEAEKRATTSLLQLLTPLPMKITSLRTDGKNAVGATERLWLLQNISVILPYRLAGEQAEGGGGGGGGGGGGTAQAKSSEINAATTGALPPAKEEVSIKLYSLHKISFNLSEKRGLRRLTTPCSSRHKTSGEKFYSSAKSFVIIAKVLPSAKATSRWPQEHSFMCGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM4</accession>
    <name>A0A0R3WSM4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3748</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002974">
        <property type="protein sequence ID" value="VDM23279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM4"/>
    <dbReference type="WBParaSite" id="TTAC_0000376401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267906at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133002" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12970" checksum="9CBB666D28FA5629" modified="2016-01-20" version="1">MFTSTHSMFVLVLFFASFLLVNSRLIVTECPSGTPTCSHGRCVQRIGWDEESQPVNEQRCICDPDYYGEACDLLVVSDFRSPVIISPDRVNVFALDELDAPAIPDRVNEKHAYGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSP9</accession>
    <name>A0A0R3WSP9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin polyglutamylase TTLL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3774</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003028">
        <property type="protein sequence ID" value="VDM23336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSP9"/>
    <dbReference type="STRING" id="6205.A0A0R3WSP9"/>
    <dbReference type="WBParaSite" id="TTAC_0000378901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000378901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000378901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000378901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30350" checksum="A36F8565A9B5F0DF" modified="2016-01-20" version="1">MDDVDEGCYCNWIGCFGRHLTPVLFRQVKDFQKMNHFPGSFELGRKDLLTINLSKMRARFGSENFSFYPTTFILPREFSRLKDSWRQALDRSAPRHKKRNTPASARGVGIHLVNRLTEVPRRKKSIAQVYISNPYLIGGNKFDLRLYVYMTSVDPLRLYIHKNGLVRFASQKSLEELWRYLEEQGRDTQKLWREIKSIVFKTMASAVSKMASLVVHHVASRESVHELFGFDILLDSELRPWLLEVNISPRFSFPFDNGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU00</accession>
    <name>A0A0R3WU00_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4224</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01003957">
        <property type="protein sequence ID" value="VDM24470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU00"/>
    <dbReference type="STRING" id="6205.A0A0R3WU00"/>
    <dbReference type="WBParaSite" id="TTAC_0000424001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000424001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000424001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000424001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="625" mass="68250" checksum="82636415337BFCE7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV72</accession>
    <name>A0A0R3WV72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4645</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004952">
        <property type="protein sequence ID" value="VDM25354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV72"/>
    <dbReference type="STRING" id="6205.A0A0R3WV72"/>
    <dbReference type="WBParaSite" id="TTAC_0000466201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000466201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000466201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6239640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000466201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17323" checksum="4738104225C7B07D" modified="2016-01-20" version="1">MMSGSGAAVYPSEVSGAASGHRNGRGHGSHPYGPQPFLGGMDLYGGVLSPATSRMLMQSPLGGLPFGGLSFHGLGNSRPFDRCNGGNCGHWGGCHGGHCGEFYDFRPCQTPECFYGSIHGFDCSDGFCKRVCNGPSCRDFVIHACSGKGSPTSNHSGNVVSDNNGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVA9</accession>
    <name>A0A0R3WVA9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4683</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005080">
        <property type="protein sequence ID" value="VDM25436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVA9"/>
    <dbReference type="STRING" id="6205.A0A0R3WVA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000469901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000469901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000469901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF76">
        <property type="entry name" value="ADRENODOXIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM25436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000469901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14648" checksum="639CA373213C1848" modified="2016-01-20" version="1">MLRSVRRVSGLFAATFMRSNFVPRRASLEYSTDPSNSHRGASVQLTFEWPCNGTRKTVSANVGDTLLDVVSENDLDIDGFGACGGELACSTCHLILSDDVYNKLPNPPSEEELDLLDIAPNTTDTQVLVELAISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVF6</accession>
    <name>A0A0R3WVF6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005196">
        <property type="protein sequence ID" value="VDM25545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVF6"/>
    <dbReference type="WBParaSite" id="TTAC_0000474601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000474601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000474601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000474601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8769" checksum="EEF2D98428CD94DF" modified="2016-01-20" version="1">MKSRSFACNLELLRGTSGECCFEEARGDVWFQSQSTSPIDEVRSALGCVSSRSELPLEALLMRRYALRLMARSKLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVM3</accession>
    <name>A0A0R3WVM3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4798</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005365">
        <property type="protein sequence ID" value="VDM25667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVM3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVM3"/>
    <dbReference type="WBParaSite" id="TTAC_0000481301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000481301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000481301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155648at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000481301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18337" checksum="3BC05706D49FC972" modified="2016-01-20" version="1">MSYHRRLDFSVPQNVRIRAINPHIVILSWKPPAGPNGRITSYTVEWFVDKRRQKNILINSGHFYAFKGLKSGQTVEASVCAHNQPATSVKLDYIGSRSDFVKITTPSDKRAKGSVAIRVVKKKKPPAAASEKKTKDGAGFTLKRKKTKVVVSAISGSKAGGSPTTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVM9</accession>
    <name>A0A0R3WVM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4804</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005391">
        <property type="protein sequence ID" value="VDM25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000481901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000481901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000481901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280457at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000481901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48015" checksum="1F270920560290BF" modified="2016-01-20" version="1">MSGGNIKPGPAAGDSETRNAPVIETFVNRESELGTLSEPRPATLQVNALITPVQHRQSMPYEGVSARLADHPQSTRIFSGVHVTPAHLTGQASINVRETPSTQFGQNQQNNNMLFQKSTLHVQLTGVKQNRRIGPKTNILQHYSIINGKDICLLNQISPLHDFPNSAGTCRTMLRKTVVYRKAHAFCLSTSIVALVPILLESCFLLASLYIKNNCAIIASFVSRTAVLSIIIVLLELTKSSLQKVKLSKSTASYSSNTASIDFPTSRNGFEMCTKKGLALPVLILSSSVDCAVDRRRCDEKTLLTMVQILLYLTLLVILFGAAVWLSLKRFDLLKHETFGNASSGSSPIIEPKKECSTSDINVGLFILVTHALLMTLRLVIYCTSSWTKGMCLLTAHRRSTAVHGPLFPLMEVPLPSLDHLPVFHQHAESGASQTFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVX3</accession>
    <name>A0A0R3WVX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal_S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4899</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005625">
        <property type="protein sequence ID" value="VDM25850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVX3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVX3"/>
    <dbReference type="WBParaSite" id="TTAC_0000491301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000491301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000491301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM25850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000491301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21891" checksum="3408F83C0A8BC1BB" modified="2016-01-20" version="1">MAVLQKEMRLFGKWQSDNINFSEFGLVDHIQIKAQHPLLPHTAGRYQVKRFRKSLCPIVERVCNSLMMHGRNNGKKIKALNILKHTFEIIHILTNENPIQVLVNAIINSGAREDSTRIGRGGTVRRQAVDVSPLRRVNQAIHLLCTGAREAAFRNVKTISECLADELINASKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWR3</accession>
    <name>A0A0R3WWR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ApeC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006525">
        <property type="protein sequence ID" value="VDM26429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWR3"/>
    <dbReference type="STRING" id="6205.A0A0R3WWR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000520301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000520301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000520301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10425948at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000520301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18313" checksum="76EBD4EB9357739D" modified="2016-01-20" version="1">MTLNFSCVRPVFYPLSLSTTTTTTIDEIGILSPQGFCQGVGERRVPTVHTLHDAGTTCAVNVTNVVFPAGSYCFYRTAKVCPPGLPELQTSVFEGLVRSFLLQTMFLPSPALSDEKELCCQSEESLGAIELPLNITAPFALPALQASCQSFVGFTVDQTKGFCEYTPITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXL3</accession>
    <name>A0A0R3WXL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SKA2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007708">
        <property type="protein sequence ID" value="VDM27077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000550301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000550301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000550301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000550301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16691" checksum="8C4D8BDF542FF16D" modified="2016-01-20" version="1">MDESEFVVVNEDNKESTGLDNLAEVVQAYGAARDSLLKSVTLLHDTLNLNMELALKNTPPDFESNSDDLMRRILGSLHTSSEGVLRNHVKSLCSKLVAVKKEYEDLSNKYEALNVQASSGSSVSSAFLSVVSFLIASCLNCEFRIDHYWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXR2</accession>
    <name>A0A0R3WXR2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5539</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007892">
        <property type="protein sequence ID" value="VDM27181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXR2"/>
    <dbReference type="WBParaSite" id="TTAC_0000555201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000555201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000555201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000555201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13010" checksum="713A817CD71C0FAB" modified="2016-01-20" version="1">MVDLEHHVRQIQLNLIHFVVARYQRMEVERKKIRVQKTVSQQPMIRTHSFTVPSLADQPEVYDVSVTADKSVAFHVIPGLHLGNRVDEGFNCMNKGWDYGLQDSRSWMSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY83</accession>
    <name>A0A0R3WY83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BTB_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5709</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01008658">
        <property type="protein sequence ID" value="VDM27496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY83"/>
    <dbReference type="STRING" id="6205.A0A0R3WY83"/>
    <dbReference type="WBParaSite" id="TTAC_0000572301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000572301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000572301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="KCTD8/12/16 H1" evidence="8">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM27496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000572301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26179" checksum="3DB2F245888EC24D" modified="2016-01-20" version="1">MSTKVVDLNVGGCLYTTHQSTLTTVRGSKLTKWFSDTATSTLPVDKNGRAFIDRNGELFAYVLDYLRDSKNSVLPKSSTTLERLQIEAEFYELPNLLAAIQETKRTAPCTITLSYRGQIPNGRDTLADVRFRRITRILVSGKSSVCREAFGETLNESRAPDCGPEDNRYSNRYYLTHNTLEMAFDKLLEAGFTLAGCCGETSVETGSQRSKSIGDFDGGRNQFFHEFYFVRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZE7</accession>
    <name>A0A0R3WZE7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZE7"/>
    <dbReference type="WBParaSite" id="TTAC_0000616501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000616501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000616501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6224839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000616501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13142" checksum="D21EC4607A50A737" modified="2016-01-20" version="1">MDEPTNCTDHFELFKNDIETRSSELMHHLESSRTSFWENLRACREYVIERINFLFSELELQAMNDQKEIDEKAQELGIGIMNTFEKIGACVSTIDACKRTLKNLSFDARASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZQ8</accession>
    <name>A0A0R3WZQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prospero domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6281</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WZQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000629601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000629601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000629601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038576at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="8">
        <location>
            <begin position="568"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="229"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A0R3X0C0</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="338"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="VDM30774.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000656201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="942" mass="107083" checksum="F4380B2ED748E27E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X195</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000695801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14747" checksum="6A2AF1C685CD8BF6" modified="2016-01-20" version="1">MASRLLRRVWNKEFRDYLCSTHFWGPVANWGLPLAALGDLKKNPELISGKMTFALLCYSALFMRFAIRVQPRNLLLFACHFTNEAAQGVQGLRFIDYWHLKSEEQREAIRKSFLMPAPELALEKAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1F2</accession>
    <name>A0A0R3X1F2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1F2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1F2"/>
    <dbReference type="WBParaSite" id="TTAC_0000702701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000702701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000702701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000702701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="34760" checksum="B0802C5AF23B356D" modified="2016-01-20" version="1">MISDVKLSIATDLQLDFRDILNYGLFLPPANETPLTVAVQLPKPKSVIMVLVAGGAHLDYRAADSSTPLHKAAIGGNYEAIKVLLDLGQSPNTRDSKGLTPLYQCMLNDTSAMCAERLLFDHSTIGVTDGAGMEEIHQACRFGRVQHLEQLIAYGANINSQTTFNGNTPLHFCAYNGQESCARLLLFRGANRTLKNRAGHTAHQEAVLANHVTTATLIRDFQSKDVVPLRGSPKYNEKRRQASQIRPLGERCSSLGRLTENFNSTEVLSPPPILAKSPFPEITLKSPNDATMGHMSASSSGYSLCNERSCELGYFLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1R2</accession>
    <name>A0A0R3X1R2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7154</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1R2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1R2"/>
    <dbReference type="WBParaSite" id="TTAC_0000716901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000716901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000716901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000716901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13303" checksum="9E03EF1B7F979F26" modified="2016-01-20" version="1">MAFIYKSLVSVGDKLCPTSLQPVWNHPAGPKTVFFWAPTFKWGLVIAGLADLARPAEKVSVFQSTALAMTGLIWSRYSLVIIPKNWNLFSVNIFVGGTGIYQLLRIYRYRRSQNKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X270</accession>
    <name>A0A0R3X270_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7348</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020364">
        <property type="protein sequence ID" value="VDM31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X270"/>
    <dbReference type="STRING" id="6205.A0A0R3X270"/>
    <dbReference type="WBParaSite" id="TTAC_0000736301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000736301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000736301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028342at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000736301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36726" checksum="BBB3947C4B4913A8" modified="2016-01-20" version="1">MSKQESGSEGANYNSNLNSDMFFGHFNRNLFDYIPLFHFLFKTRSKLNSANVNYTTNDSRLFEVFQREAIDCYFFSFLSSKKYVPVPPPAVLSCYLRISGAPFTHVQKGGYSRNPKRHSHEIYDGMLRIADASKEFKENETLNLQDALQLECKNFPPPVTRFSMEANEGSNTQKCPSSREPRKPYPCDLRIKHRLPRGLTAGRRVDDVGSHGNKLSLTRRRPYTAFDLASAVKAICSGELGTRRAASMYGIPRSTLRNKICKLNEIRKHEETLRGGQPISLSDFFHQFASSGKPPKDGPCESETIWRPSTVATPYGLASVFKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2A2</accession>
    <name>A0A0R3X2A2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020368">
        <property type="protein sequence ID" value="VDM31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2A2"/>
    <dbReference type="WBParaSite" id="TTAC_0000740601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000740601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000740601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263361at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000740601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70191" checksum="A372AF76699B2D48" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2F3</accession>
    <name>A0A0R3X2F3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein mL62</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase ICT1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7451</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020374">
        <property type="protein sequence ID" value="VDM31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2F3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2F3"/>
    <dbReference type="WBParaSite" id="TTAC_0000746601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000746601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000746601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000746601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13607" checksum="7047DE1F700D7176" modified="2016-01-20" version="1">EIQITYTTSSGPGGQHVNRSHTRVQESHRITKDGHFIIHSDRTRYQLLNQADCLERIRRMIRERLAELKKPEVSAETLEKHRKCRIRENEKRLAVKRTDSMTKAYRQRPSQWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N8</accession>
    <name>A0A0R3X2N8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pept_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7554</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020383">
        <property type="protein sequence ID" value="VDM31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N8"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N8"/>
    <dbReference type="WBParaSite" id="TTAC_0000756901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000756901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000756901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133126" evidence="7">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="127"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000756901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39354" checksum="C944AB9E8032B7F3" modified="2016-01-20" version="1">MRLIFPLTFFVCLCLARPTVIEWSQLYSPAQNLSHNEAMTLKYLWQLFIKEYNHTPSFLSFRNFKSNVMKMWKHLMESSSFSMGINKFSALSPSQYRKYLGYRPSFEKLNLTIPRHVYRKLARYTPLPEFVDWRLKGRVTKVKDQGHCGSCWAFSAIGAIEGQYQRASGNLIRLSEQQLVDCSFSFGNMGCNGGLMDNAFNYVKKVGGVDREEDYPYVSGVTEQPNNCSFKANMSVAKVTGLVDIVSGADEELMEALAFNGPISVAINAGLTSFMMYHEGIYDDQECKGRMEDLNHGVLLVGYGEQNGIPYWLIKNSWGTNWGEHGYVRIKRAGNLCGVATAASYPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Q7</accession>
    <name>A0A0R3X2Q7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7577</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020385">
        <property type="protein sequence ID" value="VDM31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Q7"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Q7"/>
    <dbReference type="WBParaSite" id="TTAC_0000759201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000759201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000759201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000759201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1120" mass="126281" checksum="AB506A1AF05E7CB2" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2R4</accession>
    <name>A0A0R3X2R4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7585</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020386">
        <property type="protein sequence ID" value="VDM31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2R4"/>
    <dbReference type="WBParaSite" id="TTAC_0000760001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000760001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000760001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000760001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21370" checksum="007362C6DAE5C61E" modified="2016-01-20" version="1">MAKHTSISIDDVERELHRLSTSSSDVATCNSTTTTTSTLNTSNVEKGTESELSSHRKREYPSPPPERIGRFRYSLFVMGTYVGLGNCVFFCCLPLLAFENIFRAMGYPQPISFLCATCHVPIATFCMCPCILCKVRRQFRKKRKIKGSFILDCLLSCLMCCCVATQLLTEARAVIIDKRNGVGKSEDGGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Z1</accession>
    <name>A0A0R3X2Z1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatase tensin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7671</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020393">
        <property type="protein sequence ID" value="VDM32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Z1"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Z1"/>
    <dbReference type="WBParaSite" id="TTAC_0000768601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000768601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000768601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000768601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="705" mass="76799" checksum="2CAFD3659925DC30" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X312</accession>
    <name>A0A0R3X312_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7695</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X312"/>
    <dbReference type="STRING" id="6205.A0A0R3X312"/>
    <dbReference type="WBParaSite" id="TTAC_0000771001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000771001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000771001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="74"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="280"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000771001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="644" mass="71996" checksum="56C7A9253BA408AA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3B6</accession>
    <name>A0A0R3X3B6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CSD_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7817</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020408">
        <property type="protein sequence ID" value="VDM32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3B6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3B6"/>
    <dbReference type="WBParaSite" id="TTAC_0000783201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000783201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000783201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203339at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cold_shock_domain"/>
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        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
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    </dbReference>
    <dbReference type="Pfam" id="PF00313">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
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        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
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        </location>
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        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000783201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="35379" checksum="1CE87BABFD059C9C" modified="2016-01-20" version="1">MTAEVAQSAEAQPNVPERKKFDILKVIVENVTGTVKWFSVRRHYGFIQRDDNKEDVFVHRTAITASRSRYPTLKNGESVEFSVVETASGVNAASVTGPNGRQVQGVRFFRRPKPLDGGDGQPKLNGATQAGGDVEGTRQRGGPRRMRRGRRPFRPNQNAMGDGENVGGEQGEELGGGLEGSRVPRQRPRRFRGGGRGRGSQRSTGTRQQMNGEDGAAVNGEEGGVSRQQQGGPRRGGGGRFRRSGGSGRMRRGGGAASGRDSEGQVENSATEEHTEDLEKKVQEMTLETKNEVSEKPKEAAAAEQQTDMEGSAAVEGVSTTITETAGASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3J7</accession>
    <name>A0A0R3X3J7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7912</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020420">
        <property type="protein sequence ID" value="VDM32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X3J7"/>
    <dbReference type="WBParaSite" id="TTAC_0000792701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000792701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000792701"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="4"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000792701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47947" checksum="48364D4521629BBC" modified="2016-01-20" version="1">MEAAPVEAINAGPEKGRGLFTTRPLMKDEIIFEEKPLICCQLSWNRFYGFKSCDYCLKPLESPQDNARRLLHDNSFVLPVILGTIDGHSPVQTFRCPSCEVEYCSETCRVASESEYHAFVCSSGPNNSFFKLEQEWRESHLLPETGTVMLLVRIAATHFSAHFRQSERAQHIVTALSRFVSSPIVGLPESNECDPCSSASLTHIMLGPKFSGNLARLHILFIEVLKEMVQRIGAPLSPNEFPNVLQQIGLDQLLSEYGFSSAMCLIGRNGQGIGASSLGAWGKSMEKILSKRGDPVEEKQFSVFLDSLYERLEEVAGDLLNVEGVGLYERQSLINHSCEPNASVRFELGTNELSVVATEDIVSPGTEITICYFDECMLLRGVHSRRKYLREYYLFVCKCPRCIREKDDNAESDTTEDEDDDYESMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X456</accession>
    <name>A0A0R3X456_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Syndecan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8161</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020456">
        <property type="protein sequence ID" value="VDM32667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000817601-mRNA-1">
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000817601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="12988" checksum="FC2A729BDBCCAE11" modified="2016-01-20" version="1">MSSEPPTLPSSNDTSSSTTSAGDTGSSVSGSPPSSPTPETDTTTSSTESTSTPSSPPGPVPPPPGPTSPPTPPSTESPSSGLSGGAIAGIVIGVILFILLLIGIYFLVKSLKVPDVQFEPDEDEGEEDYL</sequence>
</entry>
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    <accession>A0A0R3X4H6</accession>
    <name>A0A0R3X4H6_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
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    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000831501"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
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            <end position="518"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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            <end position="362"/>
        </location>
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            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000831501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="58383" checksum="9C9843304EEA1723" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4K1</accession>
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        <submittedName>
            <fullName evidence="9">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8329</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="TTAC_0000834401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000834401"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">TTAC_LOCUS8385</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020495">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3X4Q1"/>
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        <property type="protein sequence ID" value="TTAC_0000840001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000840001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="274"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000840001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52480" checksum="0690C5C964FB0AD0" modified="2016-01-20" version="1">MAERVPSGQAQIVQAPKNVAVMEGEDALFFCGVEGNPEPTIDFLLDGQSGRLSSETGKIIPLPGGGGSLLRLFKVSAKQNGIKVECIASNPVGSDKSSAQLKVYKYSDSVPAGFPRFVRSPKSQAIDVGKSAHLDCEAEGTPELKFLWLKNEIPVQIQQKTPSFDYSTKYDYDASLDAPNIDTFYPPTIIEQQERVEVRSGKGANLSCTATGNPKPQVRWLTDQEKPLTEAVEWKAILFLTDVTEPRVYICVANNSLGRIQHLVRVEIIDVPRAPADLQCLERGPTYASLRWFPGRSGDETQPDASRSLPVPITSYTLIVTDLDADNGRQALKRKLTDIAPWKVQLDGSIHLKVTDLKPDHRYTAEVYALSTKFGISDASNQITFKTLEMLYGIDGYKVYYSTHLRNKLEQWQTLQTVKLHAVLQGLMKMATYYLKVNAYNSAGDGPLSDAFPVIVNPGGASFYLYKGVYLIFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4Y1</accession>
    <name>A0A0R3X4Y1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8478</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020513">
        <property type="protein sequence ID" value="VDM33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X4Y1"/>
    <dbReference type="WBParaSite" id="TTAC_0000849301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000849301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000849301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254107at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000849301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="391" mass="46240" checksum="97A2395167A2AA3D" modified="2016-01-20" version="1">MKRRQKLHELFNKEFALLDQISLKIEEDRELRCKQLKDEIEEVRRLKEIECKELAEAGYRKRTTMNRDNYRLVLNKLYVRDLNAQIELNKQIKTHENRKEERMPVMVSLPLGFGCGSDNTKPKRDLNEELSNVMSAREARKSEIAKQKKKEAEETAEREEMHRREIAQAAKAAYERKAALRSSFERWIEERNQELESAREEDARTSAWLTSNAIQQGAAIENKSLQDKATYKQRALAFFEYAKQLQRVKLLEEERRELAMERTAGDIMKANEAKQRRMKEASQALEIKIRQAQLKQIQEKEERSFAPTTDDGPSFLDKMLGDGERGVDGKIIVRQEGSRNHQQQVYQKSAKSLFTDREMEDCEFTRPFQRFPERNLGTYEYLHPWRKQSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5V1</accession>
    <name>A0A0R3X5V1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLASP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020607">
        <property type="protein sequence ID" value="VDM33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5V1"/>
    <dbReference type="WBParaSite" id="TTAC_0000886601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000886601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000886601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000886601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="827" mass="91735" checksum="DB60E741AFCABA5B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6J9</accession>
    <name>A0A0R3X6J9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9121</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020686">
        <property type="protein sequence ID" value="VDM33845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6J9"/>
    <dbReference type="WBParaSite" id="TTAC_0000913601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000913601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000913601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264499at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000913601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32786" checksum="CB8BFBBD8B45FA04" modified="2016-01-20" version="1">MVNTLTTVVLVICIALATIAAFICAATLAVASPWWPQRKRTRRGHASGKMSTSPVNLLRRAIEAFSLTSPQTIPRTRDTSRRSSIFAESQSIPLRGHPERKRTLSSTAATPIATPPLPQYSPAPRFTTAEAPGGTINYRVFIDATGKDNLTVRVHLYYATNLPAIKPWKNSNYIVKAALIGFKSHFVQTSGVVTAVCGSPRFSEGHPSVLDFVLDCGMPFNKSEEEVQLRLMIIEFSGRKPGEKALLVATKEYRFSHHTLRGKSTLSTDLSWERCKPCIDVSSASSQYKENSFYFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6U3</accession>
    <name>A0A0R3X6U3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9231</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020726">
        <property type="protein sequence ID" value="VDM33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6U3"/>
    <dbReference type="STRING" id="6205.A0A0R3X6U3"/>
    <dbReference type="WBParaSite" id="TTAC_0000924601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000924601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000924601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000924601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="39313" checksum="D6DDD77ED49FBCBE" modified="2016-01-20" version="1">MVANMLWNRKQKGFKFGNLFKKSSTSPPPPPKLPTCVALPTSVISATDDALAVSHRRAVSDLVIVTSGSPPISPFMQQPPQTPDSGINQPSATSPFYSSSSSTFASSKMYSGSVDSAAGTTSFTSNRFSWPKSSSSSSSEASSLSTALSNNLRLTANGSTAASGNSLFTSPPKSSACTSAPVSGTEVPTTSTPQRLPRFVAGTTIAEEDEEAEEATSEVDGRTVTAAVLPLPPDSTTITPVGEVDAGFAATVAQVSRRTGTSAQELYARMKEVRRRPEDVRNRLRGQANAVVSSSSNNNGNSVGYGTAGTSKRLSLPASLHLPPHLRQKAIQLLEEPMSRRERRLSLVCLFAFRLKYSSTCDLVQPSFYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6X5</accession>
    <name>A0A0R3X6X5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PFU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9265</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020739">
        <property type="protein sequence ID" value="VDM34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6X5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6X5"/>
    <dbReference type="WBParaSite" id="TTAC_0000928001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000928001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000928001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="5">
        <location>
            <begin position="415"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000928001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="68436" checksum="D15D4632F4E1E233" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X785</accession>
    <name>A0A0R3X785_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020797">
        <property type="protein sequence ID" value="VDM34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X785"/>
    <dbReference type="WBParaSite" id="TTAC_0000940701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000940701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000940701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000940701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18995" checksum="A4BA20927E3872C0" modified="2016-01-20" version="1">MWLLSPRLCKITFLALSSTWREEGEEQEQKEEEEEEQEEEEQEVKEEEQEQEEEEQKEAKQEDEKEQQEDSPKRGAVGGLPSTSFNVVSNADAIAKSRCGFDKSQLTSARLNRLPFRLAQLEIRVVYFSPLSSTCMKMVDLVGSAREFLDFCDPKAHKTDLTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8H5</accession>
    <name>A0A0R3X8H5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9835</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021090">
        <property type="protein sequence ID" value="VDM34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000985001"/>
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    <dbReference type="OrthoDB" id="6257334at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
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            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000985001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33952" checksum="047C3489A4FD88E8" modified="2016-01-20" version="1">MPRGKSKLILNFAQLNINEKPYETTIFDDDEEASISLPPTLSRSLKCSDYRTLPWLTPYDLQSSTPPNESRSGGSAHHHKTKGVHSSRSAGHAATANSVSKLQTADFYCVNLESRFILNTGHMAWKHADNIKVKLGSPCVYFNHPEFFTKAGNIFAKEYNLKCRQEEKRREEWERARKIIQSARAAYTSGRPSFCVPAEKYTEDSQCNLTAERPKNSPPRKSPRLSGNGKPLFDPRPWRRDVLELEADESGSRPSESRSPINEAYADAHELIDNHLRMLDRQKLIEVLPVVYPHQSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8N1</accession>
    <name>A0A0R3X8N1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9891</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021136">
        <property type="protein sequence ID" value="VDM34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000990601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000990601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000990601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250448at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000990601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="547" mass="58614" checksum="2D1D8705A5EE41FD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA54</accession>
    <name>A0A0R3XA54_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase_S24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10414</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021670">
        <property type="protein sequence ID" value="VDM35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA54"/>
    <dbReference type="STRING" id="6205.A0A0R3XA54"/>
    <dbReference type="WBParaSite" id="TTAC_0001043101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001043101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001043101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001043101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14291" checksum="B70585451AB56CF1" modified="2016-01-20" version="1">MEPTIQHGDYLLVERLSLYRGQIKNGDIVVARQPRETGTCCHILKRVRATGGEAVDYWNPKLSKSVTTYVPEKHVWLEGDNKRHSLDSRTYGSVPMRHLEYRVFCRLWPLSSFGRFGKESRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA98</accession>
    <name>A0A0R3XA98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Latrophilin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10458</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021721">
        <property type="protein sequence ID" value="VDM35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA98"/>
    <dbReference type="STRING" id="6205.A0A0R3XA98"/>
    <dbReference type="WBParaSite" id="TTAC_0001047501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001047501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001047501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6312362at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001047501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12972" checksum="476D42FEF61BF723" modified="2016-01-20" version="1">MVPSAPMVDNEYGTRNNVVEVKESDFNFLNALEQDIANSKHKADSTGPGSDTESRTPPGEYGCFIPESPKDIYAHLDLAYPRKSHQTPPAPGVGSITQPPLLPPQLLQVCFSSSAYLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAG4</accession>
    <name>A0A0R3XAG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translocon-associated protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10524</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021801">
        <property type="protein sequence ID" value="VDM35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAG4"/>
    <dbReference type="WBParaSite" id="TTAC_0001054101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001054101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001054101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001054101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="61" mass="6909" checksum="8A5466F9641A67C2" modified="2016-01-20" version="1">MVDEAAIVGALEEKEDEEDDNDEEEQCWCTLIFLLLLLLLFRLVRIGEGPQLVTSTKSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC48</accession>
    <name>A0A0R3XC48_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11109</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022983">
        <property type="protein sequence ID" value="VDM36089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC48"/>
    <dbReference type="WBParaSite" id="TTAC_0001112501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001112501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001112501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001112501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8751" checksum="EBA3C6D79B2CF6A3" modified="2016-01-20" version="1">MAYRKLLHLSDHGDVRLSQRPSRRVSGSHDINSMQTRNGPRTLTHVAIRLILALEAVTKEALLSMLLAHIVALPPHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD13</accession>
    <name>A0A0R3XD13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11423</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024111">
        <property type="protein sequence ID" value="VDM36434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD13"/>
    <dbReference type="STRING" id="6205.A0A0R3XD13"/>
    <dbReference type="WBParaSite" id="TTAC_0001144001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001144001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001144001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277102at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="179"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001144001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32478" checksum="2B283E206CC0B253" modified="2016-01-20" version="1">MEMICIVHYFHCLQDYFIEVETSRANEAGTHHIGWLQIKGRLGISPILKLTDPDGKPVLQTGSTDTFRMTCESLGALQQIYVGLVDPNLTLDEEDEEPKYVNLQLNRQNQWNCRSILVSDGRDGETYLFNINQWIMATPEVDRRNCVAARPAELRITQPPKKKIDTVKDSFDATTAPTVTYRISIETGDEETAGTTANAYITLYGNQKGATSGSQRLQRISNLTFARGQVDVFFISCAKLGACLPFHPHPPSTIHLLVLKIVTLREGHCFNQTNSSLLMMDGGDWDYCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD25</accession>
    <name>A0A0R3XD25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11435</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024169">
        <property type="protein sequence ID" value="VDM36478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD25"/>
    <dbReference type="STRING" id="6205.A0A0R3XD25"/>
    <dbReference type="WBParaSite" id="TTAC_0001145201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001145201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001145201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001145201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29118" checksum="3A8F9640E6F87C59" modified="2016-01-20" version="1">MEHSSKHIDSEVLDFYRPSHITENRLSSSSHNCHPHDPHRSQPVPQLPLHLKTSSALRVPLTAAVHAAHGIHPQLLRVYQQGRPQSASQHLPGRQLHSETFRHSPQSCQSSQSGCAASVSSGTSGYASLNSNFKGGHKSSSARLRAAELIPLLRGKYAMLPGGRTRNGGPILCFPANSHADCLPLEELYFLVLYLTYLPEENVKKLGFAVIIDMRSGTTWHSVKPVLKVFDSRNLGKRIYLLAFVLCCTLFLLSYSSALCQGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD80</accession>
    <name>A0A158RD80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">[Histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS39</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000002">
        <property type="protein sequence ID" value="VDM15655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD80"/>
    <dbReference type="STRING" id="6205.A0A158RD80"/>
    <dbReference type="WBParaSite" id="TTAC_0000003801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000003801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000003801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15493">
        <property type="entry name" value="PHD_JMJD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="156"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM15655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000003801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="115279" checksum="0CE057A38D7117E8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD92</accession>
    <name>A0A158RD92_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS93</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000006">
        <property type="protein sequence ID" value="VDM15819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD92"/>
    <dbReference type="STRING" id="6205.A0A158RD92"/>
    <dbReference type="WBParaSite" id="TTAC_0000009201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000009201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000009201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260649at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        </location>
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            <begin position="32"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16784.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">TTAC_LOCUS1102</name>
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    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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            <dbReference type="PROSITE" id="PS51192"/>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17468.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000110101-mRNA-1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TTAC_LOCUS6500</name>
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    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM30719.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000651501-mRNA-1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="10">BOP1NT domain-containing protein</fullName>
        </submittedName>
    </protein>
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            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
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    </reference>
    <reference evidence="8 9" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000671901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="849" mass="95002" checksum="97B5C2DF3D916806" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF06</accession>
    <name>A0A158RF06_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8489</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020515">
        <property type="protein sequence ID" value="VDM33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF06"/>
    <dbReference type="STRING" id="6205.A0A158RF06"/>
    <dbReference type="WBParaSite" id="TTAC_0000850401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000850401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000850401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413467at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="681"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000850401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="914" mass="101642" checksum="082F7518FC53FBFB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF56</accession>
    <name>A0A158RF56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">B-block_TFIIIC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8863</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020611">
        <property type="protein sequence ID" value="VDM33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RF56"/>
    <dbReference type="WBParaSite" id="TTAC_0000887801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000887801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000887801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262911at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="165"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="515"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1581"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1660"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1887"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1594"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1888"/>
            <end position="1897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000887801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2139" mass="240890" checksum="1D17F97EDA655365" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQ74</accession>
    <name>A0A3P7EQ74_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000462">
        <property type="protein sequence ID" value="VDM18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQ74"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="444" mass="50759" checksum="21A84DAD9FE3C4A7" modified="2019-02-13" version="1">MPKSDLSWSYDDIKTQKHEIPRYELYCSFTSHESEFDYLKSLEIEEKINKIRWLPQQNSSRHLLSTNDKTIKLWRLSERLKQVTGYTIRRSTVPPPLEVSIGEVEERVGSDEASVRGAPRDLNGSTSAGVHSAGDLRVPRYERRADLFVIAQPRRVFANAHAYHINSISVNSDQETFLSADDLRINLWNLSVTNQSFNIVDIKPVNMEELSEVITAAEFHPTDCSLFMYSSSKGILRLCDMRQQALCDRSALTFQEPDIPENRGFFSEIVNSVTDLKFSNSSRYVLSRDYLTLKVWDMNMATGPVEVYHVHDYFRSKFVALYENDCIFDKFECAWSPNNNYLLTGSYNNLFRVFDRSSGRGVLTETEANANGIPSKGPLRTREVTCDPVAITSDQISVDSIDFTKKLLYLAWHPSTSRVALASNETLFLVSALQEQQYLQSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EUN8</accession>
    <name>A0A3P7EUN8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003209">
        <property type="protein sequence ID" value="VDM23656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EUN8"/>
    <dbReference type="OrthoDB" id="2133332at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="118" mass="12706" checksum="95299BA2BB81128D" modified="2019-02-13" version="1">MDPTELIARALKAKFANMRHELDSPESADSPKKKTLSDENDGEFTPPPIPVFQTPVVRRVCDGGARDALRSGPTSDATSATVAFGRHILRPVNRDKLPLTVLSDLSFDTSGSTSATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZI3</accession>
    <name>A0A3P7EZI3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4'-phosphopantetheine phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive pantothenic acid kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with PKM.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001958">
        <property type="protein sequence ID" value="VDM22004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZI3"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF35">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-0944">Nitration</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="95"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM22004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="237" mass="27110" checksum="FAE32AB35D4FD066" modified="2019-02-13" version="1">MENTWSLTYFPNIMERLGRLDWAERQMELAQGFLTGNIFDWGASEAVRFFTQSQDSVDGMASFEQALAKLQFEFLNWYSLETLAAPMPSSPLKPRPWLVDDFSRWLERISNPADRPRCVLIFCDNSGADLILGVLPFVVECLDWGSKVILTANSVPAINDVTYRELLFLLNEVAGLENRLKQALESGRLMCVDNGQSSPCLDLRQTSHRLVQLVKQEKVRLFHPIRYLVAHRRKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F089</accession>
    <name>A0A3P7F089_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01007756">
        <property type="protein sequence ID" value="VDM27103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F089"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM27103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="297" mass="32619" checksum="A8F95DD73AB56059" modified="2019-02-13" version="1">MNATDDDEGDFGKVTYSIISGNEEGHFELDEQTGYLYISRPFTTTPISASSVGQDTNSTTALGASTTNLLFENRLRMLSFKTFRLYIRASDQGKPARTTTAVLDVRLSGLIVPTHNPKLPTSLSRPIIPSLHTSATYREQKVVQSKSNQQNHLQGSKLHQYQQQDHESLISTESLIIITVMVAAVAVLLFIVVLLATACLRKRMLTEQSRRHCPTTMKSKLKGTDFELQFTGEEGERGAGGEGDNSAVAKKIYGVSSQPPTFIDSTSTYVTVTRNTLKRDNSCHRGNVAVSNGMLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F096</accession>
    <name>A0A3P7F096_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001905">
        <property type="protein sequence ID" value="VDM21927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F096"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="268" mass="29060" checksum="337B6864BF24461A" modified="2019-02-13" version="1">MNDAFRVERLIQRAVSPNTLNVAEGKSALMIAAENDCYETMQVLLDHGASVTQTDKFDNIALHYAALAGHFNAVALLLDHHSPLNVVNSSQCTPLMSAAKAGHAAIIRLLLNNDAEMTWELNDNNESALTLAASTGCPETVELILKSVPRNSRCVGALNVALRQAVKSDSKAAVQMLINHGADVNHSDEDNSEVIFEAVKRGCARMARCLKANGAQIDVFDKEGYTPLMRATKANDVEMVVTLIALGTDLGLRYLLAILCVHFKYLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F674</accession>
    <name>A0A3P7F674_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003555">
        <property type="protein sequence ID" value="VDM24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F674"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="144" mass="15657" checksum="57A5F5F8ED4FA793" modified="2019-02-13" version="1">MDNEFGHYECGDGDEIHCLEGWTGANCQTPVCDKNGCGVGGICVAPGRCECKPGWGGVNCEICLPRKGCKNGVCVEGGDCVCKPGFTHWLCDKAVVSFEEVNGAETTPSVVHTHSFFILHFSTCLFIFPLVKLNFHFRAIFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F7J5</accession>
    <name>A0A3P7F7J5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020372">
        <property type="protein sequence ID" value="VDM31801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="213" mass="23836" checksum="AE077F4E828FF3FD" modified="2019-02-13" version="1">MAYCIYLLLKVEPAILPSLNILDIQTGRFDPKAGAWFSRLSYHTVQFGTDYGHWNGRSLWINHTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEIYCCITTVECFGYLAAGTVALRNRVTLRCCGKNGGQDFVQMERPHSCVRAVSQYKFIYFYLGLPKGSVQPYGHRALQSVVRGIRGSIFAGTLFSLFPAASLLTSLHNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FC08</accession>
    <name>A0A3P7FC08_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006438">
        <property type="protein sequence ID" value="VDM26374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FC08"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="115" mass="12002" checksum="C019DBC9CEACB5BB" modified="2019-02-13" version="1">MGLHRLAAKAQLLELVDKHAALHGDEGEKVEGSGESEVRQQIVDISTNTNVISPFTCFVCVDPDKIVAVVVVVVVVVVVVVVIVVAAVVVKVSVAVVAVDDGRALFLTVDECDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FI94</accession>
    <name>A0A3P7FI94_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022503">
        <property type="protein sequence ID" value="VDM35890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FI94"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="175" mass="19010" checksum="0BDB707F1D508D2D" modified="2019-02-13" version="1">MQQLPQLNSTGSLIPEGGDEAAKSSGERRSKDAPFPTLRQTSFPCSFSRLSQMPPVPLSSFHSPPRPGNGDGGLRLSPLAVPCPPVGRLLEFSSLSERLWGDVRESERLLATAVAAAALDRRPGSLANLLCQSLAAGHQKSSNFPQTRKWSHLVGQLMIFKIENIGFSYRIMDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FSN4</accession>
    <name>A0A3P7FSN4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FSN4"/>
    <dbReference type="OrthoDB" id="6262976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="42310" checksum="D2C9EF22F6F56FB1" modified="2019-02-13" version="1">MASAKTNSTGGGGDGGGGGGGGGGGSSGAGGWSRRAADAVLAEAAHADKMMRSAAGAAYRSACQTPPAQMGRCHTRDYFRASITSSFDAIGGCSCEIGCHVGSGPCSSTRQNPSYYPPTTSLCLECQQQQHQNHQSVDTCCQQWSAHHAHHCQMSHAMSHTRASCSCEECNTSYREQEPPCRLPLSSYQRNAQPKSPFAEEETGTTQTCPACAGLAAAASQECGLSDGSYNEVQCAPPLLKDPDAALADVWASAAHHRSGRSIAAIPSSVSRRSGCYNTENLLAECISGDGGCGGSQFSYMVDCTQCQQCDAERYATGIGSKPDSRVLRRVATVARDIAEIVRGIRYFQRKNEEKERVQKIINEWRTVGGVLDRLFFVCYIIAISISIILYFPRPAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FUM7</accession>
    <name>A0A3P7FUM7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020432">
        <property type="protein sequence ID" value="VDM32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FUM7"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="152" mass="16806" checksum="E53195C827A2A52A" modified="2019-02-13" version="1">MTVGDMMNAVEREFSIHRSRQRLIFKGRSLIDESAKLSSLGIEIGAKVMLIGGREVADPSEIRKLDELEVSLKSIQSQFASLEATYNCPTSSADHSVRKKQTKGIKAVTEQCMMNLEKADSIVLPDLIISAEELQLELDCVYNDPSISDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FW12</accession>
    <name>A0A3P7FW12_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Headcase middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020575">
        <property type="protein sequence ID" value="VDM33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FW12"/>
    <dbReference type="OrthoDB" id="10012848at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031947">
        <property type="entry name" value="Headcase_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16002">
        <property type="entry name" value="Headcase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase middle" evidence="2">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Headcase middle" evidence="2">
        <location>
            <begin position="417"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="561" mass="61474" checksum="7A044A8FE900D5C3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FZI0</accession>
    <name>A0A3P7FZI0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020597">
        <property type="protein sequence ID" value="VDM33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FZI0"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="458"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="512" mass="59030" checksum="2A80862CD6E37CD9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GYZ0</accession>
    <name>A0A3P7GYZ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007648">
        <property type="protein sequence ID" value="VDM27052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GYZ0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="77" mass="8597" checksum="3141C3AFF66FCA30" modified="2019-02-13" version="1">MQELASREKNTVYESTPSARPEDVVTADSSIDDYQNLSGAKSIREKFQDPSKLQHEVKKTVSSATTKLTVLYSFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHX4</accession>
    <name>A0A0R3WHX4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS165</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHX4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHX4"/>
    <dbReference type="WBParaSite" id="TTAC_0000016401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000016401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000016401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000016401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40778" checksum="57AEEAB4A13A8026" modified="2016-01-20" version="1">MGEVDVISTINFNVNNGYLEGLIRGLKGGILKQSDYLVLVQCETLEDLKLHLQDTDYGNFLANEPGPLTVGIIEEKMREKLVSEFRYTRNQAFRPLSVFLDYITYSYMIDNIVLLITGTLHERPISELITKCHPLGTFMQMETLHIASTPSELYNAVLVDTPLAPYFVDCVTKHDLDELNIEIIRNTLYRAYLEDFYRLCESMGGATAEIMCNLLAFEADRRSFLITINSFGTELTKEDRAKLYPRCGKLHPYGLAALAKADDFDQVRHIADYYAEYKPLFDDSGDASGEKTLEDKFFEYEVQLNLDSFMQQFHFGLFYSYIKLKEQEMRNIAWIAECVSQRHRAKIDSYIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIR5</accession>
    <name>A0A0R3WIR5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS506</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000046">
        <property type="protein sequence ID" value="VDM16553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIR5"/>
    <dbReference type="STRING" id="6205.A0A0R3WIR5"/>
    <dbReference type="WBParaSite" id="TTAC_0000050501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000050501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000050501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="199"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000050501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46522" checksum="FBD8DEC272A4BB0D" modified="2016-01-20" version="1">MALDAKFFQDMTMVLAEKDSDEALEKFRSVLDYITSLSSALFVEAVSNVASMICQGTVTVITARQIGTELIHYIDSFPDDQLVISAFVQVLSRLQSRVIALEVQLANLRDLLAQRLVKVGDLREAVTVLRGIPIDSHTCVYSDEYKLEICSRIVDGFFKLKEPDNVESAINSVSKLLNSCKDERLKMRFKIAQAQLMDSKRKFLEAGQRYIELSIRFREISTDAERTAFLEHALLSAILGGAGQQRARLLAFLYKDERCHALQAFPILERMHKQRLISRENMRSLRPLLIQYYPHIFGDGGQQLEEVLERVVVEHNMLAASYLYSNITLENLGELLEVETSQAESIAAQMIEENRMVAQIDQIDGVVYFDKDSGATSANTRMQNLWASLNHILEGIETDHPQWVAARLGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ71</accession>
    <name>A0A0R3WJ71_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS704</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000081">
        <property type="protein sequence ID" value="VDM16869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ71"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ71"/>
    <dbReference type="WBParaSite" id="TTAC_0000070301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000070301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000070301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2107370at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="941"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM16869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000070301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1128" mass="127764" checksum="5DF79EE314139443" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ98</accession>
    <name>A0A0R3WJ98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Radial spoke head protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS735</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000086">
        <property type="protein sequence ID" value="VDM16913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ98"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ98"/>
    <dbReference type="WBParaSite" id="TTAC_0000073401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000073401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000073401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="313308at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000073401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46016" checksum="DF36809F6D12DC47" modified="2016-01-20" version="1">MACCRQNKKAAYIYSSLPVVRGNVGANLAITILDGNEDDDVTRSSHLLRSVKRRRKDDKPPGMKLVPTRPKFGDASSAEDRVVEANGRISIHTQTGLYLFEISDVIETDDYGVQTEQFIDRPMSPVIEFVKTGIDFTTQTEPWELFDFNTEVVPMLEVLLNRTMEQSLMEVMEEEELAEIRAKQAAFEEVRDAELAEVKRLEELNRRRREEQKRRREQAEYAAIMKRQTIEKIAARSFVKGYLEPLLPNTFELLTARGFFYDDVRLELEVNFIDNIVEKAMDMYTLELRGRIIVDGIIREAVNRRHTEYRDLGREIATEAIMEKVVPALRTRVSGAFVETMIDFSIERMEVTAAARRRVLRNVTSDVMDEIINEAVGKIMTRMAEENVDGSNFVDERGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJB0</accession>
    <name>A0A0R3WJB0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS750</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000089">
        <property type="protein sequence ID" value="VDM16935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJB0"/>
    <dbReference type="STRING" id="6205.A0A0R3WJB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000074901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000074901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000074901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000074901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30521" checksum="79A8D628EE16F547" modified="2016-01-20" version="1">MGGDGGSIPRRVELVRSKKKKENVGKVAVDAAKWKHCALSQQPLRQPIVACQLGRLYNKEAIIEKLLDESKYTSSVANHIRKLRDVCDLKLTPTPKELQSHELSSGIIENSAETFCCPILGQEMNGSYPFVFSWECGCVISKRAYDAVKDSSCLNCGTPLKPNSIILLNPESEEELKIAQDRLKVFKESCKKDLADIGGKRSSSFTNLAFIASKKSKTELRDEEVEKNASAPVYASVQDDPNASSAFKSLFTTSEEARRQPKAHWVTFNPLYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJC1</accession>
    <name>A0A0R3WJC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS764</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000092">
        <property type="protein sequence ID" value="VDM16955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WJC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000076301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000076301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000076301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000076301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48453" checksum="C28312370FE9E47C" modified="2016-06-08" version="2">MPEVEGLEDCVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPEITRPEGKDYSIHRLILGTHTSDEQNHLLIASVQLPNDNTQFDPSNYDPERGEFGGFGAVTGKIEINIKINHEGEVNRARYMPQNPCVIATKTPSADVLVFDYTKHPSKPDPSGVCEPELRLRGHQKEGYGLSWNPNLNGYLLSASDDYTVCMWDINATPKEGRIIDAHTMFTGHTSVVEDVAWHPLHESVFGSVADDKRLMIWDTRSCGSTSTGAGTTATASKPSHCVEAHAAEVNCLSFNPFSEFILATGSADRTVALWDLRSLHMKLHSFESHKDEIFQVQWSPHHETILASSGTDRRLHVWDLSKIGEEQTPEEAEDGPPELLFIHGGHTAKISDFSWNPCVPWVVCSVSEDNILQVWQMAENIYNEDEPPLAIEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKI3</accession>
    <name>A0A0R3WKI3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cwf21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000224">
        <property type="protein sequence ID" value="VDM17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKI3"/>
    <dbReference type="STRING" id="6205.A0A0R3WKI3"/>
    <dbReference type="WBParaSite" id="TTAC_0000122401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000122401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000122401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000122401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10478" checksum="81586D60A1904F1F" modified="2016-01-20" version="1">MVEEEDLPAEVYYGSSNSDAKFLAKMRERERFEEENFTRVSLTKRERLLQKRLERGEFLSTGTRMDHIRKLLESSGEEEEMSFVKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKL4</accession>
    <name>A0A0R3WKL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1259</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000237">
        <property type="protein sequence ID" value="VDM17708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKL4"/>
    <dbReference type="STRING" id="6205.A0A0R3WKL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000125801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000125801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000125801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000158">
        <property type="entry name" value="dnaJ homolog subfamily C member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000125801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="31584" checksum="9F0DB851F7E51FF0" modified="2016-01-20" version="1">MTDKERLFSEFYSEVKIIEKRDSTLTPKQQIDRLNRPGCTYFNLNPFDVLQVDPEAKMSDIKSRYRQMSLLVHPDKNQDDAERAQKAFDAVTKAYKTLENNESYRKCLEVVQEAKDRVIQMVSEKRIKAKGQTIDEDDPAKYRHAVYVQTCKLFADLERLRVDEETKQQNERHCFWQYVGIFLQSVVPFFLNEEISIFRKRKAEEEEMHRFRVQYDREWRDNYEESRKDRVRSWRNFTAKKAKKGESLGGFKPPKTRMEQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKV1</accession>
    <name>A0A0R3WKV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1356</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000275">
        <property type="protein sequence ID" value="VDM17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKV1"/>
    <dbReference type="STRING" id="6205.A0A0R3WKV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000136901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000136901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000136901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276567at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000136901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35050" checksum="DF54ED2DDFA16A59" modified="2016-01-20" version="1">MTSIGMIVSALLTPNEKCCLENIATRIITINIACVARLYKSENQQWVRISSGVVTLEDNAALRVVSIGFYDLNKCKKLFKTDLYKEMEYRECGPQFHSFNGVAGPLGLAFACPKEAHDLFASVQAKLNSSPSKTGKFANLVHKAREADVKFAMKDFQHIKHVGIDSDGKDLEVKAQNKELARELLEALGVASLSENEIKAVCSMIDRCGATEVQEALEMHSYQELAEPSQPIPVSTPPFAPPPPPPPPKQLVNADHSNLLDSIVGFDASNLKQVKKADKVESLPTKGSDNVHAIETALAQMLKNRRMYLNEYDSDEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKV9</accession>
    <name>A0A0R3WKV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1365</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000277">
        <property type="protein sequence ID" value="VDM17875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKV9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000137801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000137801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000137801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10532860at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000137801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32727" checksum="B6A71FD9F1E1613D" modified="2016-01-20" version="1">MLDEVEEAVMEEREERAASVPREMEDDVSSSSSSSSNSSYPNRRDKQGPEEEEEELEENDDEDDDDSQAEDRSAARRDLEQEERWLRIRQQLLLRRSGANRRALAKVERRLWEISQSGSVGRRFPVEMDRVRQARSQSHHHHHKRNRRLSTDPSSRLPDELTDLREFNTCPEGYDYVDAERARELLRPETARQEMRFDIHHRVGQGVEGSEDEEEAGERTKRKKSRKKKKKKKSVIGAAGYLEASLFGSEISSSSSSPSSTNSDDCEGGGGGEDGIIRSDALKEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL65</accession>
    <name>A0A0R3WL65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1488</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000341">
        <property type="protein sequence ID" value="VDM18090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL65"/>
    <dbReference type="STRING" id="6205.A0A0R3WL65"/>
    <dbReference type="WBParaSite" id="TTAC_0000150101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000150101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000150101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000150101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28087" checksum="C3FCD1A3AFD8AF11" modified="2016-06-08" version="2">MSTEVRDVPVAVRLPPSKWKLPDTNNNLGDYLPNFTLQTETLSCRGRNWLIVLQLFFGELVASAMITFPYFLIDPTLRYCAVSEALAVGGLVYAAVWLIYPISGAQINPIITLAFGLTRRICLYFVPLYWIAQFLGAGFSMSIAYYVSPFLNCAPDMGMTVPRNGITVFQALWLECLITFLLLIVILAGTDEARETVWTMGDGSTLACVYMLMYFAITIVTVSLLIVLQLTHHICVHDKSLGVHARFGLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLC0</accession>
    <name>A0A0R3WLC0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">High-affinity choline transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1545</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000369">
        <property type="protein sequence ID" value="VDM18189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLC0"/>
    <dbReference type="STRING" id="6205.A0A0R3WLC0"/>
    <dbReference type="WBParaSite" id="TTAC_0000155801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000155801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000155801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM18189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000155801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65078" checksum="9282955F9236D763" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLU7</accession>
    <name>A0A0R3WLU7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000467">
        <property type="protein sequence ID" value="VDM18441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLU7"/>
    <dbReference type="STRING" id="6205.A0A0R3WLU7"/>
    <dbReference type="WBParaSite" id="TTAC_0000173501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000173501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000173501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261200at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000173501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="568" mass="63775" checksum="8C3C52305DFE138D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLX1</accession>
    <name>A0A0R3WLX1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4158 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1746</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000486">
        <property type="protein sequence ID" value="VDM18483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLX1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000175901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000175901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000175901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000175901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10961" checksum="B05FFDFD88659176" modified="2016-01-20" version="1">MTYTTHRDTQATLHILDEADMDVAECTDNDLYKRFGLEEQYEVNQLTTWQRIKPKIWAVFEMPRSSVAAKVDVPNSLHDLITLAIVKLAFLIPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMK3</accession>
    <name>A0A0R3WMK3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1978</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01000657">
        <property type="protein sequence ID" value="VDM18718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMK3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000199101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000199101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000199101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000008">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="12">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000199101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28236" checksum="5741BD34D05981D7" modified="2016-01-20" version="1">MDQSIEASAPNGFHGCYLLVSLNPRCNGRTYVGYTVNPRKRIQQHNSGSQCGGAKATGGKGPWVMVLVVHGFPNDISALRFEWAWQNPYQSRRVPYVHPKAKRETPLQFRFRVLCNMLRVRPWSRLGLTLRWIDQEYVQEFPPSLSPPLHMSIAYGPIESSEPTIETRLHGGKSCHLCRHKFETRSGPSIWILSCPSNCENGIWHLLCLARHLTKDDQELLPLKGLCSSCKIELIWPDLLKNRKEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMT7</accession>
    <name>A0A0R3WMT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PI3K/PI4K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2062</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000724">
        <property type="protein sequence ID" value="VDM18823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000207501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000207501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000207501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241136at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000207501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56090" checksum="74E0D267A985315D" modified="2016-01-20" version="1">MEAIKATSTSHSTVADTAEIQVGEAESTPEKAEKSIQTSRVKSRRRLERRHSVHNNNFTNEKTGSRRSRRSLPFYVRSKYATMTVNSGNRHLWGPQPDSNKEEEETVGDLTSCIYVTSSDGTNYRVTFIVVNAALEPLFLLPRNSPPTRNEKISQISSRMKVYEDPGRLNYVTVKRPKFSLIESTMSEKPAPPIQVYISSPITPKTGVSSISRPEKSHITGFIYISTDGFVLKVRVPPLSIKKVRNPITEEVRSTMERLKMPCSEEYKNKARLLVRLINDLFRVSFDLTNCTVTRLSEHKSLAVQTENHMIIRQCFSHFTNKRVNLQLPESTYIYHDPMVEIRRVNHYFANLNIAPLWKYQMYQKRITRMRDHNTMEGEIEKVIKRARGSTMIFDGFDAIVTAIGGLMHGIVVRGDEAYEAKIHTFLGDRKETETERMISEWRFEEEEEESQKETNPNVNSYRRHLWGSEEVEETLESLNMPSTVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPG3</accession>
    <name>A0A0R3WPG3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vang-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2638</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Vang family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001317">
        <property type="protein sequence ID" value="VDM20744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WPG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000265301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000265301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000265301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8887313at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20886">
        <property type="entry name" value="VANG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06638">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM20744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000265301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49555" checksum="8F7B8639E7BF2E9C" modified="2016-01-20" version="1">MDQDSVVSARSDKSGINQQQQPVLQNFSVQSPDPRQQINYPASSAFPSDVPRNHTEIQVRGMTLGQSPMFSQQGSSVSQHPGYNSNWNVPQPTNQPFLPYTSPTMFPPQQCMTMMGWSGPPPMPGCQPSAAFPMQPLAPSSNQSYPQTQSNQPLIPVDTSGITPKISHAHAPISSNRNGNQQMDQYGHDENAWAENATAVTGATSETGLSADNMSRFGARYGLFASLGVNNSPNSCVGGAAAALIRTEIDSFPNHTCTRLFGFLVYFGLGFCSICSPVLMVIFPYLPYIGWSTDKCDHTCEGHLIGMAVKLALLGLGTWILTAPHCPILNGTRKVYPRVRLWRSLFLCLIFVILFAFWLFYSVRILQPRRRDYGSIVLFSNSLSDALLFLNFSGIALLEFQRLRSQYAVHVVRSPDGASKTYRLGEMSLQKAALEILQMYMVDFTVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPY6</accession>
    <name>A0A0R3WPY6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2811</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001536">
        <property type="protein sequence ID" value="VDM21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPY6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPY6"/>
    <dbReference type="WBParaSite" id="TTAC_0000282601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000282601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000282601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF11">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="108"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="219"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="330"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000282601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="50240" checksum="72960814BE3743CD" modified="2016-01-20" version="1">MLLNILGLVDCYNLEVTRYANTHTSTSAPSTATSDSHTEYLPLNVDGESLIQVKATESRPLLTPPRPPQPDSFSEEEATGGEGGESVEGRKVDSEDIGNLRDLFSIPEPSSLTFQCSPSASISPSPLPSLGIESGSGLSSNVSSESGHQYHQHRHASVTKPLSLRVRHPSSARSAMEQIRYTLTGLEIGTKYRVRVQALNAVGVSPFSGILHFSTLPPLPMPLTLCCIGTTASGIKLRWSSSVEPYETDGAHSKSKLPASANVRYILEMSKKPESRGWVTIFEGPQTSFKARKLSEATHYYFRVAAVNISGKGAFSEVLQEKTAYSQPPPVEAPQAVDVSNTQCKLQWPALTITGQDPLLYLVQLTRVPGISITTTIPKTVSRSLQSIESETAASAGAVAEAWEGEEEAVTVYRGAETSCTISNLISGTNYIARVCAIRCCQTEPSEQSPFPTSRIKVNQEPDALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ61</accession>
    <name>A0A0R3WQ61_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2886</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001636">
        <property type="protein sequence ID" value="VDM21434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ61"/>
    <dbReference type="WBParaSite" id="TTAC_0000290101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000290101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000290101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000290101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35625" checksum="95FD841E26E963A3" modified="2016-01-20" version="1">MVHTVGQHCAGAHPQVCPLCEARLTPLDVESFNVDPCVQLLVLDRHLREAHLPHLEIAGRLFQSFDETVIAKNMLKTPPIVDAVTRSYRCCFKAGESAGNGPGFPFEHWRRRHKRSFVEDREDTTIFATSHPRGHAQRPQRTSARRRCLLNPQKLYDILRNVWLRKQDRAHNTLFSLLFHTFPPNAMWCGFTASSMAQLIAHVVGHHGGNYLLQPKLRENVRQAFSYRKERRMPSLEQWSSSLISSGKKRSGSVGTLNDAVRLLKGGNSLLEKRLLIKPVVRTLNRPTLIGEDSGNKLFDANADVNQEKVDFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQX6</accession>
    <name>A0A0R3WQX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WKF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3151</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001989">
        <property type="protein sequence ID" value="VDM22055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000316601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000316601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000316601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000316601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34800" checksum="1D6FDB9E6FFEE335" modified="2016-01-20" version="1">MAAPALDAYGVFITVLMESINRRRGGEGGGWKQIEFRCGNLQALGREPTDITYNCEMTIEEISKSSKRHKELPKFSEDGQATGKGSQSSGQKRRAKFTEQSNSQVDASKSPKKRKKSLEVATDSVQEGQEVLKWRPKAESAFEEPKKISAVVGKLKLPKKSVKFADELVTSNSQSKHKPIVSILKVSSPFTKALSESSVDPPSVEVEKTNDADVKGAKTKSKKPRKSKNALKRIKWVKRHRKKILSRRKRRANRELARSRPQRDVQQHLAEAVEYLNAWYSSPETWKYKKVAQLTLIKHAFNPALVSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSD5</accession>
    <name>A0A0R3WSD5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3660</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002820">
        <property type="protein sequence ID" value="VDM23090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSD5"/>
    <dbReference type="STRING" id="6205.A0A0R3WSD5"/>
    <dbReference type="WBParaSite" id="TTAC_0000367501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000367501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000367501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001346">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF631">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000367501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15296" checksum="7252F78A724B0964" modified="2016-01-20" version="1">AASAGKWPLKWYAPECIYYFRFDSKSDVWSYGITLWEVFSYGERPYKDMKGAQILAMLDQGLRLSRPVRCPEAIYAVMQQCWNAEGVRRPTFAELVLTMSRLAKGPLFPNNFSSCHENERGASVSGESAGAFAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSG3</accession>
    <name>A0A0R3WSG3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3688</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002875">
        <property type="protein sequence ID" value="VDM23157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000370301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000370301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000370301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10662744at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBP10 C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000370301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32253" checksum="FCE74E8399E1538F" modified="2016-01-20" version="1">MMRGDEATERGLSMSSAALDVGVNNFALSAEAARLDVQGDEVGISYGRPAGSKKVLQVWDRKKKRFVNPEVAAGKANVARIKTESGATIPASYKTDRYKMWLKKSKVDMESMGNQAEVDGSGETANASKTTKAESKKPKDKFISLFNARYGSVVEFMDLEDDGNMNGTFFNRRSGTQWSKKNKRANHDNETNNTTTKNGNRSGFKVVGTMSRFHRTLQNATKRKTLEETKEIKQAKGSRTFGQMRKPEQILKLRRRKEKQNQFRLRNKAKRSGRGGGRKEKQKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSK2</accession>
    <name>A0A0R3WSK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3727</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002936">
        <property type="protein sequence ID" value="VDM23232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSK2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000374201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000374201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000374201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM23232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000374201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12695" checksum="F6F38243C8B147EC" modified="2016-01-20" version="1">MPRDQGLLLGPSNGVNGDVSTTPQPSSRFEESVHPMKITETQMNGTQSQETPRNANICAGCGMVIWDRTMLSAMEQNWHNHCLKCHCCGGRLAEMGTSLFHRGNMLLCRQDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSR7</accession>
    <name>A0A0R3WSR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Niemann-Pick C1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3791</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003066">
        <property type="protein sequence ID" value="VDM23387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSR7"/>
    <dbReference type="STRING" id="6205.A0A0R3WSR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000380701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000380701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000380701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000380701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25112" checksum="467943F25B7D3A59" modified="2016-01-20" version="1">MGKSVGIGAPNHINIRQTCLSTACTSTQLRFPLQDIECFVLLLLLLLLLLGSVFYVFYEQYVNIVYETVVQMCLGLSAVSLITWVMLGLDFVATLNVVVAVASIALSVAAAMVLWHISLNAISLVNLVVCIGISVEFCAHIVRTFAISTKATRVERALDALSEMGSSVLRGITLTKFGGIVVLGFAKSRLFQVFYFRMYLCMVLFGAVVGIIFLPVQLSYFGESQVVVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSZ9</accession>
    <name>A0A0R3WSZ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3874</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003204">
        <property type="protein sequence ID" value="VDM23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000388901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000388901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000388901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000388901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9146" checksum="2E4090DD906EF34B" modified="2016-01-20" version="1">MCPADVTARLSPQILHNQWAVRLFTSPSSRLNVAPPDSLTCRHTLPPTLTSAFFAPSPLLPLFVPPPPPPLSVYCLLNSTPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTA3</accession>
    <name>A0A0R3WTA3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3976</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003401">
        <property type="protein sequence ID" value="VDM23902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTA3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000399301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000399301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000399301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cleavage and polyadenylation specificity factor 2 C-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000399301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25400" checksum="5B8E26EC9F871C29" modified="2016-01-20" version="1">MDLQALTGKNTAYFYLQFSRSDGKALRKIITGLRPHEVILVGATRSAIDAMVDHCRSDLQLKDEVIHTPSGMDVVNCTKEGDIYQARMKDSLVTGLRFTKIREYELAWVDADILEPEENMNPTNAMEVGADGEASWITTLASDALPVLAPPSGPVIDHPTVFVNEPKLSDMKQLLLNQGLQAEFVSGVLVVDNCVSIKRTETGRMTLEGLISPTYFIVRDILYRQFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTB0</accession>
    <name>A0A0R3WTB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD_binding_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003420">
        <property type="protein sequence ID" value="VDM23920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTB0"/>
    <dbReference type="STRING" id="6205.A0A0R3WTB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000400001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000400001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000400001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266969at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000400001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12655" checksum="89F4A5A434EE7668" modified="2016-01-20" version="1">MLAEFFDFIVVGGGIAGVVCAETLCGLIAPQLLGLTADEDASSRQRRVCLISASPTLKTVVNVRHVTRLLESFDVAERDSEGWSHAWPHILTVLIDKVAKVKYVRHASFVFTFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUX6</accession>
    <name>A0A0R3WUX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004739">
        <property type="protein sequence ID" value="VDM25166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WUX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000456601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000456601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000456601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000456601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16341" checksum="1119A69A2F83F275" modified="2016-01-20" version="1">MAEVPHKPGVFYSDHAVVTAEFLIMRHRESIAEEVPPVNSHETLETILMEADGIIKKQMKMEDQKKTIHLVIAAVLILAFLILGTGVPVCHPAYKFFASALLMLAGAGAFCLIWGNVIGRPCLMSSLRNAKAIVWNHLSELTQVPASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVQ1</accession>
    <name>A0A0R3WVQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4825</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005435">
        <property type="protein sequence ID" value="VDM25723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000484101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000484101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000484101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000484101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9896" checksum="13FF05752482D4CC" modified="2016-01-20" version="1">MGLKRIDKEDFWAEDVEEAKSLMAKRKKQEEGGGKGKKPKNDIQPSRYFPSHPTSSSSLLYHSNGLQAQFEMVGTIAPEKNCVNRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWW1</accession>
    <name>A0A0R3WWW1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein mago nashi homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5236</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006709">
        <property type="protein sequence ID" value="VDM26542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWW1"/>
    <dbReference type="SMR" id="A0A0R3WWW1"/>
    <dbReference type="STRING" id="6205.A0A0R3WWW1"/>
    <dbReference type="WBParaSite" id="TTAC_0000525101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000525101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000525101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM26542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000525101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16927" checksum="EE703476FE2CE96D" modified="2016-01-20" version="1">MADAFYLRYYVGHRGKFGHEFLEFEFRPDGKLRYANNSNYKNDTMIRKEATVSKAVMEELKRIIIDSDIMNEDDANWPTPDRVGRQELEIVCGDEHISFTTSKIGSLIEINNCKDPGGLHTFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX96</accession>
    <name>A0A0R3WX96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trithorax group protein osa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007212">
        <property type="protein sequence ID" value="VDM26818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX96"/>
    <dbReference type="STRING" id="6205.A0A0R3WX96"/>
    <dbReference type="WBParaSite" id="TTAC_0000538601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000538601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000538601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000538601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="179" mass="18844" checksum="D2EF618AFED92078" modified="2016-01-20" version="1">MNEAAYPQRSWGNGPYASEPQGRPLYANTMAPHHPPPSQQQQQEALYGPPGMGYPPPSTNVRGMPPAYHHRGSPAAAGYYASGYMEPQQQPPPQPGPMTSPNPRACYPTNTPSSMDTTTNTSGYTSPGTAGRMGLGDDFMTGAPVLDAGAKPSANPSTPTSSGAPPDHRWFSSAQMCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXB5</accession>
    <name>A0A0R3WXB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007315">
        <property type="protein sequence ID" value="VDM26871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXB5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000540501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000540501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000540501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000540501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23325" checksum="99715F4CC8355B99" modified="2016-01-20" version="1">MPNETVLRTLKANLPLRTDLYNSVANSAVLKAVKNKDVDSVVEIGKVLGHQRFHILYLIVIPRLLSLGLGPGEVLAKFEDPSLKSCAALGIVLNELCALPSFLNPPVPGSSLECAKQFIAQFQNEGLLPFTYYLSVNNSFIHLLLRGCVKHVIQSRNDGIIDQTMLDVWTGALLNCFAPDRHPLLASALLRFCGQGIVGAADSTASRFASLDDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXM2</accession>
    <name>A0A0R3WXM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubulin--tyrosine ligase-like protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5497</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007745">
        <property type="protein sequence ID" value="VDM27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXM2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000551201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000551201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000551201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60477at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057954">
        <property type="entry name" value="SET_TTL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027749">
        <property type="entry name" value="TTLL12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46088:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25556">
        <property type="entry name" value="SET_TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin--tyrosine ligase-like protein 12 SET-like" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000551201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17639" checksum="A5EA90B40BF0E1A7" modified="2016-01-20" version="1">MDQYTYDDFLRHHAPVLISMQVPELYWPSVHNKLLNKIFDAPTKFDLGMLNYTSETTHEVVERELFVSVKVDEVRFSNPESVFLVDHAWTFELPDVRNTLKSNATLLLRMKTMMCIEEETEDEAIEAVMQKMWKCVSGIILFLRSPTFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXN6</accession>
    <name>A0A0R3WXN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anoctamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007814">
        <property type="protein sequence ID" value="VDM27138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXN6"/>
    <dbReference type="STRING" id="6205.A0A0R3WXN6"/>
    <dbReference type="WBParaSite" id="TTAC_0000552601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000552601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000552601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000552601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15264" checksum="3E2BEC7F685897E4" modified="2016-01-20" version="1">MAWQRHYQIRQFYTWNDVAQRTEVAYYAAMSRPRITAKDAIVAAYERLGPVCGIIMAIGWMIEWFLIILLEWFKPSNTIGRVPHFLTTPSQFEVWNRMDTSPYGEGETEATPDSGTGEVCCQSTTCHHPHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY72</accession>
    <name>A0A0R3WY72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5697</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01008617">
        <property type="protein sequence ID" value="VDM27468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY72"/>
    <dbReference type="STRING" id="6205.A0A0R3WY72"/>
    <dbReference type="WBParaSite" id="TTAC_0000571201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000571201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000571201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM27468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000571201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33385" checksum="637D95B6C079474E" modified="2016-01-20" version="1">MGITGSDVSKQAADMILLDDNFASIVTGVEEGRIIFDNLKKSIAYTLTSNIPEITPFLIFILADVPLPLGTITILCIDLGTDMVPAISLAYEEAESDIMKRMPRDPFRDKLVNERLISMAYGQIGMIQASGGFFVYFVIMAENGFWPSRLLGLRKQWDSPAINDVADSYGQEWTYTQRKRLEYTCHTAFFASIVIVQWTDLLICKTRKNSIYQQGMWNHHLTFGLFFETTLAIFLSYCPGLEHGLRMMPLRWTWWLPALPFSVSIFVFDEVRKKLLRTLPPGNWVERETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZD2</accession>
    <name>A0A0R3WZD2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6129</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZD2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZD2"/>
    <dbReference type="WBParaSite" id="TTAC_0000614401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000614401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000614401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
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        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01771">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="160"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000614401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35287" checksum="C788203E1526E2D3" modified="2016-01-20" version="1">MLSSVLHPVTPNCYCVRPRAKVTVVGGGSVGMACAFAIMMKALPISLLFFRTEKVKGEVMDLEQGQQFLNNCRIQGGSDHALSAGSDIIVITAGVRQQPGESRLNLVQRNTDIYKDLIPSLVKHSPDAVLLVVSNPVDIMTYVTWKLSGFPRNRVLGSGTTLDSARFRFFLAQRFGVDPQSVHGIIIGEHGDSSVAVWSKVTVGGCNLSSINPAIGTDSDTENFGQVHKDTVGAAYEIINRKGYTAWAIGVSTWKIVDLILNNKNAVIPVTTAVKGLYGITDDAFLSLPCVVGATGVASVVNIPLDDAEITSLQKSAQLLRETTDGINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZN1</accession>
    <name>A0A0R3WZN1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6253</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WZN1"/>
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        <property type="protein sequence ID" value="TTAC_0000626801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000626801"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="608"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="806"/>
            <end position="938"/>
        </location>
    </feature>
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            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000626801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117940" checksum="2A3BCEA3FA4935AF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0R4</accession>
    <name>A0A0R3X0R4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lecithin-cholesterol acyltransferase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020319">
        <property type="protein sequence ID" value="VDM30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X0R4"/>
    <dbReference type="WBParaSite" id="TTAC_0000674601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000674601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000674601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190846at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133148" evidence="1">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000674601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49407" checksum="12B801600FB79497" modified="2016-06-08" version="2">MFFPSYKLFFSEVLLLLVLASSTSHSHLLSMAALKSWIAGRLPHPLILVPGDGGSQAYAQFKDHESDPFQIWIDLRYLISPRTFSDYFKLKYNNATRRTEENDKAIITFPGWGETWPVDNLDSHPHSVTRYFQDLTAAFTQNPYYVPNSTIRGAPFDFRRAPNENEDFNPKLKRLVEDTFHNGKDQRVVLLGHSMGALYALSFLKNQSDIWKRQYIKAFVAVSAPFGGSIKALKIEASGDNFGIYFGNPLWYREVQRSMPSLAFLLPDPRLWPKDEVVIYTAAKNYTVHDYKEFFSDIGFPEGFQMYEDTKLTVDGLIPPTGVEKVYCIYSSAVRTPGTLIYPSAFPDAQPNVVYEADGDGTVNMRSLSVCQSWANGSEGVDQVETLVIPGVNHLSIVLDPRFITRVKEISHAEQPMPPRESFWQALLNSLSWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0U5</accession>
    <name>A0A0R3X0U5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS6766</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X0U5"/>
    <dbReference type="WBParaSite" id="TTAC_0000678101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000678101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000678101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="14">
        <location>
            <begin position="835"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="2354"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="724"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000678101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2562" mass="277510" checksum="D1C4E2D86C08E0EA" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0U9</accession>
    <name>A0A0R3X0U9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6770</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0U9"/>
    <dbReference type="STRING" id="6205.A0A0R3X0U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000678501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000678501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000678501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133086" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000678501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59603" checksum="1E50090E675BC612" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0X0</accession>
    <name>A0A0R3X0X0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6792</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020323">
        <property type="protein sequence ID" value="VDM31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0X0"/>
    <dbReference type="STRING" id="6205.A0A0R3X0X0"/>
    <dbReference type="WBParaSite" id="TTAC_0000680701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000680701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000680701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="264"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000680701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="985" mass="107644" checksum="4D5B528F2CDF8FC4" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1K6</accession>
    <name>A0A0R3X1K6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Coiled-coil domain-containing protein 170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7084</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020344">
        <property type="protein sequence ID" value="VDM31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1K6"/>
    <dbReference type="STRING" id="6205.A0A0R3X1K6"/>
    <dbReference type="WBParaSite" id="TTAC_0000709901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000709901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000709901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="478"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000709901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="739" mass="83238" checksum="8D488B655A83B2D3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1U9</accession>
    <name>A0A0R3X1U9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Microtubule-associated protein RP/EB family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7199</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020352">
        <property type="protein sequence ID" value="VDM31540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1U9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000721401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000721401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000721401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000007">
        <property type="entry name" value="Microtubule-associated protein, RP/EB family, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="245"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000721401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35337" checksum="0487D26DB5341656" modified="2016-01-20" version="1">MVELTTNVYSTNQTADNLSRHDILNWINTCLESSYGKIEELCTGAAYCQLMDMLFPGVLNFKKIKFNTNLEHEYIANFKQLQAIFKKLGVDKEVPIEKLVKGKYQDNFEFVQWFKRFYDANYTGQPYDALAARGGEQIRSHEKPSARPRPVPPRTSVPTTVRTSDSRPGAPHSHVFFNLAGVIVSMAFTISAATKNAASARSTVSSSSAPRTNAQSSGDSMQMNALRIEIENLTSQVCFLNFGSICVYNSCNHRIVLFQAEEDRRTIEGLVQERDFYFSKLRDIEDLCRGMGDNEFAKKFLDILYATEVSVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X241</accession>
    <name>A0A0R3X241_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="12">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7316</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020362">
        <property type="protein sequence ID" value="VDM31680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X241"/>
    <dbReference type="STRING" id="6205.A0A0R3X241"/>
    <dbReference type="WBParaSite" id="TTAC_0000733101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000733101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000733101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000733101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="634" mass="71342" checksum="24B888C25F4C1170" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2H1</accession>
    <name>A0A0R3X2H1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020375">
        <property type="protein sequence ID" value="VDM31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2H1"/>
    <dbReference type="WBParaSite" id="TTAC_0000748501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000748501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000748501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10463563at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000748501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19569" checksum="1A369378557B5528" modified="2016-06-08" version="2">MDYPKRQFMFRFHENIYKAHDFIFDKKTTRETVPQLCPMIVPSSAPHATFCTAASNDASNSTHSRGYAVSSHTSPWCRKMREEPMSIVKKRLLSLRMYDHIMNKNANQHMQMRPFLSPDAHCRHGWGTVAYGTPVGVLRSPYQYNGRACPCSNGLPMRMEFPVYYTQGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2X8</accession>
    <name>A0A0R3X2X8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020391">
        <property type="protein sequence ID" value="VDM32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2X8"/>
    <dbReference type="WBParaSite" id="TTAC_0000767201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000767201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000767201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000767201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8665" checksum="30C4E103E61BB3F8" modified="2016-01-20" version="1">MVKLWFGSSIVTLSLRGRLRVWFAEDMLHPEGSHDESPSRGLGLAKCTVPRRVLLAISACAGVPVPLAACPSHSRKLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X364</accession>
    <name>A0A0R3X364_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">INCENP_ARK-bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7751</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020400">
        <property type="protein sequence ID" value="VDM32200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X364"/>
    <dbReference type="STRING" id="6205.A0A0R3X364"/>
    <dbReference type="WBParaSite" id="TTAC_0000776601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000776601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000776601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284286at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000776601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="767" mass="83452" checksum="FEC10E939C11F36C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3S7</accession>
    <name>A0A0R3X3S7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8003</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020430">
        <property type="protein sequence ID" value="VDM32487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3S7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3S7"/>
    <dbReference type="WBParaSite" id="TTAC_0000801801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000801801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000801801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000801801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16165" checksum="3581C48D4C63F8DC" modified="2016-01-20" version="1">MTSRKEFVQVFGRKKSATAVALCKAGNGMIRVNGRPLALLQPEPLLPKVMEPIMLIGQDRFEHLDIRIRVSGGGRVAQVYAIRQALAKAVIAYHQKFVDEFSRKALKDTLAEFDRTLVVADPRHCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3X3</accession>
    <name>A0A0R3X3X3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020439">
        <property type="protein sequence ID" value="VDM32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3X3"/>
    <dbReference type="WBParaSite" id="TTAC_0000807501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000807501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000807501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275777at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000807501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61492" checksum="655E676ED5B185CB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4F2</accession>
    <name>A0A0R3X4F2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="9">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8274</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01020475">
        <property type="protein sequence ID" value="VDM32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4F2"/>
    <dbReference type="STRING" id="6205.A0A0R3X4F2"/>
    <dbReference type="WBParaSite" id="TTAC_0000828901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000828901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000828901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000828901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40574" checksum="3C07E556B527A25F" modified="2016-01-20" version="1">MAHPVVDVTLTASVPHDLVFEKHIAFLKSFEKNGDPMLDYLRLSAIYWSLTALDLMKSLDVINRAAVIEFVKACQNADGGFAPAPGHDSHLLSTLSGIQILAMFDEFRCFRREEAVKYIAGLQNPDGSFNGDKWGEVDSRFSFCALAALSLLGVIPFGVCDFAQPTEGVDIQMAVEYLVRCQNPDGGFGTRPGSESHAGQAYCVIGALSLLGQLRQLDIGKAAWWLAERQLPSGGLNGRPGKQPDVCYSWQVWINYDEWVLASLTILGRLIWIDAADLAKFICASQDSETGGISDRPGNVPDPFHTLFGLAGLSLLSRLGAKMEPEMNENVDEKTRNPLPVALHALREVNPVFCMSQHIIDRLSINVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4G8</accession>
    <name>A0A0R3X4G8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020478">
        <property type="protein sequence ID" value="VDM32817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4G8"/>
    <dbReference type="WBParaSite" id="TTAC_0000830701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000830701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000830701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000830701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9844" checksum="948B94E03995C23E" modified="2016-01-20" version="1">MAVPRHNSESTVDVGLLSGRTKGLGSLKTPPSIAVFQNSEPLHSLYRRDFNDVPKTLRQCLALTSVDDLRVSWQTSLKPCRCGRQRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I3</accession>
    <name>A0A0R3X4I3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8308</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020482">
        <property type="protein sequence ID" value="VDM32836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I3"/>
    <dbReference type="STRING" id="6205.A0A0R3X4I3"/>
    <dbReference type="WBParaSite" id="TTAC_0000832301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000832301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000832301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12725">
        <property type="entry name" value="RRM2_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="581"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000832301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="842" mass="92528" checksum="E99BCA1FDDEA1FD7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4M3</accession>
    <name>A0A0R3X4M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear pore complex protein Nup85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8355</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020489">
        <property type="protein sequence ID" value="VDM32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4M3"/>
    <dbReference type="STRING" id="6205.A0A0R3X4M3"/>
    <dbReference type="WBParaSite" id="TTAC_0000837001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000837001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000837001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000837001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="114170" checksum="28C3E887B87AD35C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4T6</accession>
    <name>A0A0R3X4T6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="3">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8424</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020502">
        <property type="protein sequence ID" value="VDM32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4T6"/>
    <dbReference type="STRING" id="6205.A0A0R3X4T6"/>
    <dbReference type="WBParaSite" id="TTAC_0000843901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000843901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000843901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000843901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57289" checksum="7644CEA39BC3AAC4" modified="2016-01-20" version="1">MQPNEIIALGDNASAIKSHCHKVVFIRHGESEFNQENRFIGWLDSDLSSRGECEARQAGQMIKQRSLYFDIAYTSVLKRAIKTCHIVLEELDLLWIPVLKCWRLNDRMHGALQGLTQNETTNRYGQCQLQLWTKSYDIPPPALLSTDPLLPEFDPRYALLDHNILPKTECLKDTVKRVLPYWHDEIVPAIKKGKRVLIVAHANSIRALIKHIDYIPDGKVMDIEIPSVAPIIGFRSTMEKPSEQSSYQLVLIRNGESEFSKNNLFCGWTDSDISYRGECQSEDAGKLLVKRGVEFDIAFTSLLRRAIKTCHIILEQMGLLWIPIHKSWRLNARMYGILQGCNKSKLALQHGEDQVRIWRRAYSGTPPTLSRDVKQHPIFESKYALLDRTLIPDTECLRDAYERLLPFWNDEIVPTIKEGNRVLVVAHGSTLRALMKFLDHISDENIADINIPPCFPLVYDFDEHMKPIRRYYLKDDEMVASAIRMAINETKLDPQPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4U7</accession>
    <name>A0A0R3X4U7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020506">
        <property type="protein sequence ID" value="VDM32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4U7"/>
    <dbReference type="WBParaSite" id="TTAC_0000845301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000845301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000845301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000845301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12040" checksum="3B1FF06E04CB58FE" modified="2016-01-20" version="1">MSCIHICRGHQLSSLCFVHNDRIGGRDLIASSTIWTVVFATITSQMDHTPPLLLPSSMESNIDNAKTTPIALSVRTSSPPPPPSPTVANPPSTQHPINSHLIPIRPTGRSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4V1</accession>
    <name>A0A0R3X4V1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8443</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020506">
        <property type="protein sequence ID" value="VDM32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4V1"/>
    <dbReference type="STRING" id="6205.A0A0R3X4V1"/>
    <dbReference type="WBParaSite" id="TTAC_0000845801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000845801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000845801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000141">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000845801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="36261" checksum="D285FEF9959ABDF7" modified="2016-01-20" version="1">MATGPVEERNQDATIYVGGLDEKTKEAILWELFLQAGPVVNVHMPKDRITGQHQGYGFVEFLSEEDADYAMRIMNMIKLYNKPIRVNKASAHQKNLDIGANIFIGNLDPEVDEKLLYDTFSAFGVILQTPKIMRDPETGNSKGYAFINYASFEASDAAIEAMNGQYLCNRAITISYAFKKDSKGERHGSAAERLLAAQSPLSQADRPHQHFADAPIPPPPPPPTLLAAATAGIPGAVQHPAAFSTLTAAGAASMLMPPPPPPPPSISLAPPPPPPPPMLGAAGAGLMPPPPPPPPPPTLFAAADAAFHPPPPPPPPPPQLAGGVQPWGLTGAGIPPPPPPPPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5R4</accession>
    <name>A0A0R3X5R4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020592">
        <property type="protein sequence ID" value="VDM33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5R4"/>
    <dbReference type="WBParaSite" id="TTAC_0000882401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000882401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000882401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6239159at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000882401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31086" checksum="0DBBD0456EEF5152" modified="2016-01-20" version="1">MRTAMKEIDNDSPKAHPLNNRAKCISISANHYTHENGFAPSREKIRKIVDEYPGDGTDDSVVSVNEIYQFGIEDKENNEVYLLDFVDSLKVSYSVKVSDVTQDSLEKLPPLLHDRLFADYLSCTASDILCKISTTLDAWMDEVEEAKFISRHLAAFDELIVLRKQVFTLLKLFVPNPDVKEGFDCTTADLDRYLLRIIQDLTTNNRSLGGEASTGSPVVSVCTEPEHCVHILRQRVLTLLQTLLPNLLLPESFDLKRDLQDLINAIYSYNMPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5T3</accession>
    <name>A0A0R3X5T3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8831</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020601">
        <property type="protein sequence ID" value="VDM33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5T3"/>
    <dbReference type="WBParaSite" id="TTAC_0000884601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000884601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000884601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000884601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9372" checksum="AD9E72BE855B7D06" modified="2016-01-20" version="1">MARITSNIIDAFPDYYPVSYATAIDELRQCCHRCSGDVSLFNNVVLLMNEMQSINPEGLHCLFSIDRLSGLFVPASDPPSSASSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5X6</accession>
    <name>A0A0R3X5X6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8877</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020615">
        <property type="protein sequence ID" value="VDM33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5X6"/>
    <dbReference type="STRING" id="6205.A0A0R3X5X6"/>
    <dbReference type="WBParaSite" id="TTAC_0000889201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000889201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000889201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000889201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10213" checksum="A6EE501515412CC6" modified="2016-01-20" version="1">MTERKAVIKNADMSEEMQQDAVAVAGQALEKFNIEKDIAAYIKKEFDKKHSPTWHCIVGRNFGSYVTHETQHFIYFYLGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X657</accession>
    <name>A0A0R3X657_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8963</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020638">
        <property type="protein sequence ID" value="VDM33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X657"/>
    <dbReference type="STRING" id="6205.A0A0R3X657"/>
    <dbReference type="WBParaSite" id="TTAC_0000897801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000897801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000897801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000897801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13462" checksum="247B8A4AE82BAD4D" modified="2016-01-20" version="1">MENEVEAKEAEAPPLIMEINDENDMESLKEMSHKSLVIVDFFATWCGPCKSVKVAYEKLAEQETDVKFAKLDIDIYEDAPSDYSIVAMPTFMAFKNGEMVDSVIGPHIEQVKQMVARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X698</accession>
    <name>A0A0R3X698_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020653">
        <property type="protein sequence ID" value="VDM33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X698"/>
    <dbReference type="STRING" id="6205.A0A0R3X698"/>
    <dbReference type="WBParaSite" id="TTAC_0000902201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62192" checksum="09C2E0902DFA2C61" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6J3</accession>
    <name>A0A0R3X6J3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9114</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020683">
        <property type="protein sequence ID" value="VDM33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6J3"/>
    <dbReference type="WBParaSite" id="TTAC_0000912901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000912901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000912901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000912901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8838" checksum="06AD6B487821C199" modified="2016-01-20" version="1">MVAGFLKPLDGLESHFRSSFRLNGKMQWKNTVACGEETEEEEEEEEEEEEEEETEDPKLPTVRARVNQLFRSTSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X712</accession>
    <name>A0A0R3X712_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Glutamate receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS9308</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020756">
        <property type="protein sequence ID" value="VDM34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X712"/>
    <dbReference type="STRING" id="6205.A0A0R3X712"/>
    <dbReference type="WBParaSite" id="TTAC_0000932301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000105">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="466"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="477"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="809" mass="90044" checksum="56A1C8D543158535" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7G6</accession>
    <name>A0A0R3X7G6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9476</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020835">
        <property type="protein sequence ID" value="VDM34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7G6"/>
    <dbReference type="STRING" id="6205.A0A0R3X7G6"/>
    <dbReference type="WBParaSite" id="TTAC_0000949101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000949101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000949101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000949101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50984" checksum="B5A1D4BA8E4A3C6E" modified="2016-01-20" version="1">MDCEGNDVHDESEMSQDEDDKQDSEIYLPGHSRPLRDDEELVMDKSAYRMYYHLQVEAPSLSFEPLLDCMGDSRVVEINGTDPLTIYIAAGTQTQEAKDNSIVVMRLSNMRPMTTKETTDESDSDSSSDDEISNDLDSLPEVESAKIRHPHGTINRLRAHKFQESYFAATWSESAEVNVWDLRRPLLAVNDSAVMAEYSRNHESPAPLFTFKGHKVEGYGLSWSSCSTPFCNLATGDNDGAIFIWQAGPSGWTVSSKPYKGHKGSVEDIQWSPSEPTVFITTSTDRSFCVWDTRSGVRTSAMITVANAHSTDVNVASWNARQPGTLLTGADDGCIRVWDLRMVHRYYGPGGGGGGGESALTAYTHSFSFHSSAITSIEWHPTEAGIFVASSEDDTTSLWDLGLEQDAAEIEEKCDSSLPVQLVFLHSGQREVRESRWHPQVPGLIISTALDGFNVFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7X4</accession>
    <name>A0A0R3X7X4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9634</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020947">
        <property type="protein sequence ID" value="VDM34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7X4"/>
    <dbReference type="STRING" id="6205.A0A0R3X7X4"/>
    <dbReference type="WBParaSite" id="TTAC_0000964901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000964901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000964901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240959at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="277"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000964901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="679" mass="75400" checksum="6DC864905C344189" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Y1</accession>
    <name>A0A0R3X7Y1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9641</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020952">
        <property type="protein sequence ID" value="VDM34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Y1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Y1"/>
    <dbReference type="WBParaSite" id="TTAC_0000965601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000965601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000965601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000965601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="678" mass="72759" checksum="FDAD8AB3921B1D76" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X862</accession>
    <name>A0A0R3X862_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021005">
        <property type="protein sequence ID" value="VDM34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X862"/>
    <dbReference type="STRING" id="6205.A0A0R3X862"/>
    <dbReference type="WBParaSite" id="TTAC_0000973701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000973701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000973701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256412at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000973701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15100" checksum="C9C2DAA6B08FE2AC" modified="2016-01-20" version="1">MRKTDNAISIMNIIVNDIERIAAESGRLAHYNKRSKVKSLGILTAVRLLLLLPGELVKHAVSDGYQGCDQVRQLQLAVTSHTTTVSASVVLEVAVMRRESEVDVGEVLRQCVEEVAALAPVGMDMRLEGGSVCVPSQDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8V0</accession>
    <name>A0A0R3X8V0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021192">
        <property type="protein sequence ID" value="VDM34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8V0"/>
    <dbReference type="STRING" id="6205.A0A0R3X8V0"/>
    <dbReference type="WBParaSite" id="TTAC_0000997501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000997501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000997501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000997501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21439" checksum="6985647E4F9C84C0" modified="2016-01-20" version="1">MTAMHKMFLRSSNRSTMGDFNHLFSPCFPTNFTTSWNHGGKNWTVFHGSEGLQSLSGNVFNACFEIAVKVITECELGANWTKDLGNLKQMEIQATSYMCSKTEEAGEFLINRPADGRVPVRWYFDAARRACSTPLSGRPFLCMELTYISALLSHGFDLPMDKYLNLNRTIGNIEVGWPVGFLVDILLRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X911</accession>
    <name>A0A0R3X911_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10021</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021246">
        <property type="protein sequence ID" value="VDM35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X911"/>
    <dbReference type="STRING" id="6205.A0A0R3X911"/>
    <dbReference type="WBParaSite" id="TTAC_0001003601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001003601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001003601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9449012at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 6-like beta-barrel" evidence="3">
        <location>
            <begin position="235"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001003601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="743" mass="83711" checksum="F610B48EB222A855" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9A7</accession>
    <name>A0A0R3X9A7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021324">
        <property type="protein sequence ID" value="VDM35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9A7"/>
    <dbReference type="WBParaSite" id="TTAC_0001013201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001013201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001013201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001013201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7481" checksum="5A3F76D17451983F" modified="2016-01-20" version="1">MFDIVRLPLQRKPIRGVTIEINVNAVVFTDGDCVVGAVFVHCLHITHAASTTADTTERDLVGLSGHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9G9</accession>
    <name>A0A0R3X9G9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10179</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021394">
        <property type="protein sequence ID" value="VDM35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9G9"/>
    <dbReference type="STRING" id="6205.A0A0R3X9G9"/>
    <dbReference type="WBParaSite" id="TTAC_0001019401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001019401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001019401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001019401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30895" checksum="75BDC429AC1562A7" modified="2016-01-20" version="1">MTRCFWEYCLQTMMVGEVAAFMVPPRHLTVFPAVNKKLRDYMLDRTANSTNPPKHTCAFMSLQAQGGLGYSDLDDLLARPRMLEFIFDLHSVVLPDEGPKESWLMTPEEKKEAIPQLRQAGNELYAQGQWFEAAAKYEEALNLIEQLSLSEKPGDSEHMRLDQMRVPFYVNMAQCQFKLKDYYGTVQSTSEALLRDKNNVKALFRRAQAYSATSDVHLAKMDFTRVKELAPDTMTNCVDRELANLDRIDRECREQERRLLAGKMFSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9T9</accession>
    <name>A0A0R3X9T9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10299</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01021521">
        <property type="protein sequence ID" value="VDM35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9T9"/>
    <dbReference type="STRING" id="6205.A0A0R3X9T9"/>
    <dbReference type="WBParaSite" id="TTAC_0001031401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001031401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001031401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001031401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47357" checksum="633C7B920CB5D775" modified="2016-01-20" version="1">MLSLNALLISEQSVASPDHWFIQGFISYAFPCSRIFVGKNLSELRKKASNRSFSRSTSLRIICKCLDALEELHSVGYLHRDIKPSNFCLRLDNPMEICLLDFGLVRPFTRPGGVNQVRPPRPSAGFRGTVRYASINAHEYRELGRHDDLWSMYYMLVELLSGELPWQRKTGKSSVKQMKMEIDPVNLGTSGGLPQTIATTWVHELKNLNYYATPNYRELRKVIEVWLSENWINWNDPYDWQKQVAGRPESESTFTPMYKRSQPSGYPFVQNVKRPAHHDSTGCLRRLDKRGFGSTAELKRLESDGGEGGITAFGGRSTAALCEDATTNKNMATEKIMQEDGHGNFEDVSEKMDGKEKTLGSHNDLHTVGDGQRKSTETADRQFLATSKGLALVADSSSSSSPSSSSLSCPPPPPFNIPPNFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBE4</accession>
    <name>A0A0R3XBE4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10854</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022378">
        <property type="protein sequence ID" value="VDM35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBE4"/>
    <dbReference type="STRING" id="6205.A0A0R3XBE4"/>
    <dbReference type="WBParaSite" id="TTAC_0001087101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001087101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001087101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001087101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7380" checksum="DA80A2BC0B3F0CEF" modified="2016-01-20" version="1">MDLISTTGAAQRLALFEYQQALLEAEVEDLSWKIARAEITDQGALLNKMNICEKHRKTLIHEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBJ3</accession>
    <name>A0A0R3XBJ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CWF19-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10903</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022478">
        <property type="protein sequence ID" value="VDM35883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0001092001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001092001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001092001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="116"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001092001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43276" checksum="85B851FAFB5F5B55" modified="2016-01-20" version="1">MLLRVSRNLKETYLIEINIAFQKYICSFNHSRERSNHHGGKGRQNEYPREDEGSYTIEEMIRQENQETKDSYLRHFASVAGQYKGVADEYETNFVKENAKLQGVLKPRLGSDAITEYKRREYAESTCPSCMDHTPHYLVISVRHRMFLSLPEHVSLSQGHCFITPLEHVGAMTRLDKAAVEEACAFKRDLCRMAALWKGKGASCVFMEVASYSTSFKHHTQIECVPVSRETMDELPSYFKKAMLDLGSEWDQNTRLIDLARLGARVRKIIPPNFGYFCVEFGVDGGGYAKVIDNWSTFPPHFGQEVLSGVLGKSPEKWRKPKKESLEQLRRKVVEFEEKWISVEEGANETNITTQHTEAASTIPDAAECVLEPEGPALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBJ6</accession>
    <name>A0A0R3XBJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear factor related to kappa-B-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022482">
        <property type="protein sequence ID" value="VDM35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0001092301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001092301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001092301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241716at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001092301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56744" checksum="46E0E0ADBDA7C674" modified="2016-01-20" version="1">REKFPNGVPIKSIFLSQSTSLKYASGPLQSDQHVNHFLQNVETSELSSSSSTTVSPIASSTFLGTLPHEFSGFRSTPFSPHSTSVQTNSWKTFLTGSGSLMAMTTAAAAKRMLLNNALEQWPQRSSTNVPITTSDAHILSPQDVLRLPPPRQVQQFVDYINPYIKQSISPLQIHFIINQWHSFRQTLRQNRRMQRLQAAEREDVRRRKQSERQDSKKVDLFAKVVLRREAQALKKAASFAEFKRILLRANTKSSIGKRNTFSPENAVDLSEANGGVVFHLPITQKTKASLVSQRVTEEEKRSISKRSLDELELGKKEDMKSVELSSRMKEYSLSSGNVTEDDYGEDETENHSDEELREAYNSYNDFLSNACTPKNRIICTKSLFLRGRVDHSTLFLPPGIYVRRCDNSVWGSTCGGGSVVNSYQAMFNQAARLRSRLALKSLCAAADRMDAASRPGVTDLRHFDGSGSCACLLPEEECLPTEVGLKVAPVVVYNVSYLDDCCICYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCK9</accession>
    <name>A0A0R3XCK9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3591 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11269</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01023443">
        <property type="protein sequence ID" value="VDM36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCK9"/>
    <dbReference type="STRING" id="6205.A0A0R3XCK9"/>
    <dbReference type="WBParaSite" id="TTAC_0001128601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001128601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001128601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001128601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37170" checksum="E77C66A37B129BAD" modified="2016-01-20" version="1">MASVAAAASGLPPKDPLNLSNDEFYAIRSGGLFGNLARCGPLQHSTPAVELWPPFFPTYNTPSRLRQFHRVPLKQYTRGMMSQFSTPISVNNLTRIIQRKSKEREEEKMAAGGGDIFFMRTPQDLSGFDGEVVLFEYSEEFPPLMNQIGMATRLVNYYRPLLPKDPSLSPDPAGNSSPPDLPYGSLVNVGNTDSPFLGVVRPGGCLQSMENNMFRAPIYPHKTPSTDFLVIRNRNGLWIRRVPNAFTVGQEVPLMEVPGPNSKRANNFARDFLQVYILRLFLKSTDEPKRIKMEEIRSAFPNHSESSVRKRLKICADFKRTDSMMDSAATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCU2</accession>
    <name>A0A0R3XCU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2D5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11352</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023755">
        <property type="protein sequence ID" value="VDM36332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCU2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCU2"/>
    <dbReference type="WBParaSite" id="TTAC_0001136901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001136901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001136901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950721at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001136901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17144" checksum="AD3C4E14331BB545" modified="2016-01-20" version="1">SASSSSSTPSSAVCFQEALRLLYQKHAAPTGPVRPPVSAPPIQPLPIQMLPSGHRKRYSTDEVEGPGLEVPLGAEVSPSAAGSSTAMSQVFPRRQSESGLYRMTGRMQRQQPGEQMTLKRVRSEHQNLPFSMLGQQRQAGPPLALTMVLGEQVDSCSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCY2</accession>
    <name>A0A0R3XCY2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11392</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023904">
        <property type="protein sequence ID" value="VDM36372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCY2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCY2"/>
    <dbReference type="WBParaSite" id="TTAC_0001140901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001140901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001140901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001140901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12309" checksum="DCAAA92C950EBFF3" modified="2016-01-20" version="1">MTSICCQNNECKDLDIGFHLLPLHAAKSRSVEKGGAGGDTEVHGLDAERVELLVDALKQLEAGVVVTDFSPLRDDQWAVQRLSSRLPQDTSLYQVDAHNVVPVWIASEKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD37</accession>
    <name>A0A0R3XD37_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11447</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024232">
        <property type="protein sequence ID" value="VDM36532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001146401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001146401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001146401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242940at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001146401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47726" checksum="96E6F255AE206FB9" modified="2016-01-20" version="1">MLLESHFGLNFSSEFAIPTIMKFLVPRGPMSRSVPRYDGKPASVASVPTQDVTFRRTPLMRQSWGGQNQTSPRRNSSFDFRPQSVISARAVELQSSQRSSLVEPYVQPPYSPSRQSRPMYRSPPTVIQAGDQQSPQPMSFGSPTRTVRRMSFSARTIPRDQETSSMVREIWPSSQSPTSAQPLRVRVYNRRYFIRLIIFDLNGAVIDRLHRPPTHKRQCNGHNPHLSTQLTPLMGLVQPTVPHKWVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPSPLQQQQPPAQVYVPLTSVHRRTVSTPQFPQKSITIYPTTRDRQSVEASRQVYQQMTTPRAHQRSDWTVLHPTRITPTQASTNQSRPSLFGPSGGSHQQQPPPPPLPHQGRIATLPSRPRPRAVNRRSPQPDEESGVTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDA3</accession>
    <name>A0A158RDA3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS220</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000014">
        <property type="protein sequence ID" value="VDM16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000021901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000021901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000021901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17730">
        <property type="entry name" value="BRCT_PAXIP1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A158RDE9</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        </lineage>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16568.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000051501-mRNA-1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDJ9</accession>
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    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01000093">
        <property type="protein sequence ID" value="VDM16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000076701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000076701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000076701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="1326"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="1712"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="638"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1486"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1544"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1614"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1827"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1487"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1555"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1687"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1857"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1892"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1922"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2029"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2046"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2094"/>
            <end position="2104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000076701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2104" mass="227390" checksum="CACC0482DFC7B9AD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDQ1</accession>
    <name>A0A158RDQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1283</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000246">
        <property type="protein sequence ID" value="VDM17739.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDQ1"/>
    <dbReference type="STRING" id="6205.A0A158RDQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000128201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000128201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000128201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000128201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="597" mass="66966" checksum="6B59FA8D7F1B6119" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REQ7</accession>
    <name>A0A158REQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7819</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020408">
        <property type="protein sequence ID" value="VDM32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REQ7"/>
    <dbReference type="STRING" id="6205.A0A158REQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000783401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000783401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000783401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000783401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17726" checksum="A4BF81B1928F5280" modified="2016-06-08" version="1">MTDILTSDEKTRCTKAFKQFSWGKNGTVRVKKLARVMRRAGFAPTDDELRKIFESCLGRTRLTEKMFLLLMEEYKSDLQITQDLYEAFRLFDESGEGYFMTSKIRELLRAGDEALTEEDVEALCSQADSDGDGKVYFSDFARVMMTPVKEPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RET0</accession>
    <name>A0A158RET0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7997</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020430">
        <property type="protein sequence ID" value="VDM32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RET0"/>
    <dbReference type="WBParaSite" id="TTAC_0000801201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000801201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000801201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="736"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000801201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1626" mass="177308" checksum="82373E4403B143FA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF85</accession>
    <name>A0A158RF85_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9184</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020706">
        <property type="protein sequence ID" value="VDM33926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF85"/>
    <dbReference type="STRING" id="6205.A0A158RF85"/>
    <dbReference type="WBParaSite" id="TTAC_0000919901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000919901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000919901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="6">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000919901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37714" checksum="8B72650107699B32" modified="2016-06-08" version="1">MNESAFSFFITGWLIFNLIILAAIWSWQPNESFGSENLFLRTRNFFNVFQAQPHPYYHAIEQLEWISAFSHDKSDLSLVKPPKIFYDRRLLYHLTESEGCRYKCNYTDYLQGLGAGDIAVFSEAFYTVEAEYLKRRGVLIAFESVESPVHMRTLTQTQMEQVDIYGGMGKETPPGRDPLQWIAEHYKFYLAFENSNCRYYITEKVTFNALRYGMVPIVLGAYKEDYESILPPHSYINVDDFKSASELAEYLHYLDKNDTAYAEYFAWKEHGDIYVDKRLDCRLCGFMHQLNAGLVKLGNYAPQRFMDRWSLCFYRDLLPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E7X8</accession>
    <name>A0A3P7E7X8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000571">
        <property type="protein sequence ID" value="VDM18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E7X8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26890" checksum="5AD6CA37A6886597" modified="2019-02-13" version="1">MNNFESSNKTDLIDSPQKPQIRYFLKSERSIVSPPPLPTRPSVPQGSEGRTGGGVSRPTTGTLASSLNNFESSNKTDLIDSPQKPQIRYFLKSERYAGSSPSTPPRPPGTRGRCEGVTVHHLASPLLASAPLPSTPPPPPPVSAPPPPPPPPSPPPPSIQPHLTVPSITPSGGDASKDDTSKPTTGNSFLDDIRSFNKTNLKNVNAETSETRPTVGYMNPRGLESTLNNALNSLLVHQSQQIVEDENEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ENQ3</accession>
    <name>A0A3P7ENQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004079">
        <property type="protein sequence ID" value="VDM24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ENQ3"/>
    <dbReference type="OrthoDB" id="10442383at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="107" mass="11539" checksum="A8DA4C64E45F671F" modified="2019-02-13" version="1">MSGRQAAVTMSGGKGPISPLSLKQDHDDNQQTKSQQQTRLSFADYPSPVSFAEDSTESRVTPPVQKTSGSILKSSLRQSRTMQPVSAAPNSKTTFTLHFHSILADCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQ17</accession>
    <name>A0A3P7EQ17_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000441">
        <property type="protein sequence ID" value="VDM18379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQ17"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="60" mass="6210" checksum="2CEEF29044B33088" modified="2019-02-13" version="1">MSLSEFSVAMHLVVLHRNGVMLPAQLPNSLLLIATSSALSVPPPPPSSPHPSSSTHNASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERV4</accession>
    <name>A0A3P7ERV4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS4003</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">COPII-coated vesicle membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003455">
        <property type="protein sequence ID" value="VDM23953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERV4"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="11">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="13">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM23953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="401" mass="45059" checksum="FD1EC98F9B2D63FE" modified="2019-02-13" version="1">MQHYEGLANRAAQNGHVVDIFSSHLDQTGLHEMRYLVNYTGGSMTMCDSFASNLFIQSFQIFLRKDAQGHFKMGFNGQLEVKTSRELKVSGCIGSCFSANVKTPSTGESEVGIGHTSIWRLNGLTPSSTLGIFFEVTQPHGQAAAMASSGGRAYVQLVTQYQHASGQRRIRVTTACRQFIDATSQHAYLVAGFDQEAAAVLITRMAMFKAETADGRDALRWLDRQLIKLCRKFGEYHKDDAASFRLPDEFSFYPQFMFHLRRSSFIQVFNNSPDETAYYRHVLNTEDCSNALLMIQPSLIAFRLDGTDEAVLLDSTSIQPDTVLLMDSFFHILIYVGENIAKWRKAGYLVRLLSSLCFYALFLISFGLDLRIAMREILNGYKVLYSKTRHSANALLVCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EW53</accession>
    <name>A0A3P7EW53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008779">
        <property type="protein sequence ID" value="VDM27541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EW53"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="83" mass="9719" checksum="D66DEF8E720C256A" modified="2019-02-13" version="1">MEEKLAQDRGKLNERMRQLREQMHSYQDRLARDFRAQCDQEKAELSGRIKIRAEKLEEAVSQPTSLVLVCGKGAQKVEEVQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXI9</accession>
    <name>A0A3P7EXI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004214">
        <property type="protein sequence ID" value="VDM24736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXI9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="105" mass="11385" checksum="1088FDD1DC0FFECD" modified="2019-02-13" version="1">MVGSSVRKHASACENVGAAFSYMASDKLSKPAKTFFPDGLPDAFSIMGLVKLDTSGRSQTLLDVRDASKREVMSLTLDSQLVFKLSETPEFVNIIRLNHTMTGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZ86</accession>
    <name>A0A3P7EZ86_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001745">
        <property type="protein sequence ID" value="VDM21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZ86"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="37244" checksum="1FE2A65C1C53D2AD" modified="2019-02-13" version="1">MNQIKYETRNYFVDLLKLKRDSEAGGKVKIPSDIAKALDIGNTTVFSGADVEAILKMVCSYLLAFLLHYDLESFKMFRLNSTLLMLQLRERQEAIDREEIFFLNEVELMKVLERWEAHINDTAAVREKAQHDFELAKKSHPKPGRFHEPGSRAQEREQWQKGDDMPEDEFDPRAFFIMHDLNSDGVWDTEEMDAMLSAQIGQIDEDEPERQDEYRVQMRRKMLEVMDRNGDGLIDYKEHMKHSTSPDGMNDGGWEPDDDEDEDLDDFGPVPTDEDLQQISKKIHNLDTMDPDSKMVRYLRKRLDRLQHDLKRKKMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F2Q8</accession>
    <name>A0A3P7F2Q8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS3563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002642">
        <property type="protein sequence ID" value="VDM22879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F2Q8"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="8">
        <location>
            <begin position="161"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="8">
        <location>
            <begin position="255"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="402"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="73908" checksum="3A7A04642CFEA84C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6U0</accession>
    <name>A0A3P7G6U0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ryanodine receptor 44F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS903</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
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                <consortium name="Pathogen Informatics"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 13 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="277"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM22695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="565" mass="62960" checksum="5930A2093476D93A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GPX6</accession>
    <name>A0A3P7GPX6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004196">
        <property type="protein sequence ID" value="VDM24718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:extracellular matrix structural constituent"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Fibrillar collagen NC1" evidence="4">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="267" mass="30057" checksum="F27227A8619E8738" modified="2019-02-13" version="1">MTELNRALFDRIDKLWKEAQRLLKPSGNSQEYPAPSCKDIKLNNKFARNDTYWIDPNGGSPSDAVRAECIFHDDGSVETCLSTGVASENLATYKQPRSSDPDYWQSHLLVENAVSPPDLHDQSPHTQMNLLRSQHRFATQELEFFCEGTTIFGGDMNWETGVVDTSKATSLLAHNGRVIDLTKGIRHGPSANYVEKIDFESPIRKHDVSIAVEYDGCRHRQPGTSTKMRIETRDTQLLPIIDFTVKDFDHTGRSTLSLAVKAVCFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HDC8</accession>
    <name>A0A3P7HDC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDM33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:voltage-gated potassium channel complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:potassium channel regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:detection of calcium ion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_Ca-activ_BK_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258:SF8">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="409" mass="46241" checksum="76F026C6DC8A22E5" modified="2019-02-13" version="1">MTNVRIPACPPSSSNGNPPAYRPAYQLSYAAHAHDPKSKPAKQQQHQHHSTHTQMGRTEGRLRDSPSMEKPQQQPQHHHTPCHKTFSRLRKKYCSGTCLKFVYLACATLVSASVIIECILAHLVITPYISESVFESGVCFLYYTATGKRVKCENKCSKDRSAFPCANVQVIYIPAPRVQEDHIPAVIRAIRYRNPAVRQYLEVREARLLHLYDYFSTYAAYKADRCSTSPCNRREADNAETVDQYLRELHAIGLMPCYALPMRVEFTLKEMQNWRRRLNSLPMAVDTTGSPESESEEELEIGSDLDSFHILPTASESTFLPLLTIEWLREGANLSEAEAAVSRRLLHLPPPTRGELSAAALMHRLYPDTLLFHSLFWPLAIILCGLLLIALAYAVDGCKVWRTDMTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HMX1</accession>
    <name>A0A3P7HMX1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022194">
        <property type="protein sequence ID" value="VDM35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HMX1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="161" mass="18757" checksum="16C0F75ED18CAD9A" modified="2019-02-13" version="1">MNAVRATLTAALCIENFPSQVVERHNKPEIEVQTSKELLLNPVVVSRNERERVLIEGSINSVRVSIAIKQSDEIDRIICHKFMRFIMMRAEEFVILRRKPVPGYDITFLITNFHTEKMLKNKLVDFIITFMEEIDKELSEMRLAVNSRGRLCAEEFLKAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI28</accession>
    <name>A0A0R3WI28_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS227</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI28"/>
    <dbReference type="STRING" id="6205.A0A0R3WI28"/>
    <dbReference type="WBParaSite" id="TTAC_0000022601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="551"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="68298" checksum="901A01EC1759F513" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI29</accession>
    <name>A0A0R3WI29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI29"/>
    <dbReference type="STRING" id="6205.A0A0R3WI29"/>
    <dbReference type="WBParaSite" id="TTAC_0000022701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10545874at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13054" checksum="F9B7B34958FCD468" modified="2016-01-20" version="1">MASPPAGSGSSTGHSPLAHTGGSMRVHSQSPPPPSTQQQLLARDHRQRQQQAPLAPTSSSPGLERRRNLSPRQQLTAAGTATTTAASSSHSASPALSNSPIEYPVYFCYKFTEPTFPTGTSDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ53</accession>
    <name>A0A0R3WJ53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SOCS box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS682</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000077">
        <property type="protein sequence ID" value="VDM16828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ53"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ53"/>
    <dbReference type="WBParaSite" id="TTAC_0000068101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000068101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000068101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50225"/>
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        <source>
            <dbReference type="EMBL" id="VDM16828.1"/>
        </source>
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    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
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        <source>
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</entry>
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    <accession>A0A0R3WJT2</accession>
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        <submittedName>
            <fullName evidence="9">WD_REPEATS_REGION domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS948</name>
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    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="TTAC_0000094701"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="OUTER SEGMENT 5"/>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJT7</accession>
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        <submittedName>
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    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="TTAC_0000095301"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17224.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000095301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="911" mass="100455" checksum="854158B1A8E4A26E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLM1</accession>
    <name>A0A0R3WLM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1646</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000426">
        <property type="protein sequence ID" value="VDM18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLM1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000165901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000165901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000165901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="29"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000165901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="596" mass="68107" checksum="0B7E2600A5B64587" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM00</accession>
    <name>A0A0R3WM00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1775</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000502">
        <property type="protein sequence ID" value="VDM18515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM00"/>
    <dbReference type="WBParaSite" id="TTAC_0000178801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000178801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000178801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000178801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10394" checksum="06783F9E6C4699FB" modified="2016-01-20" version="1">MIHSDTLEPLKRDTGVHLSRASPHLTGRGNYIQAVRSASPLPSHSPMSEASDLILRSGLNVQVSRLGKVTHRTYGCLRGSQGVKVTCPDFVCYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMC3</accession>
    <name>A0A0R3WMC3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1898</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000591">
        <property type="protein sequence ID" value="VDM18638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMC3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMC3"/>
    <dbReference type="WBParaSite" id="TTAC_0000191101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000191101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000191101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
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        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="305"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000191101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="520" mass="56533" checksum="6336915EB6A9C2DD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN91</accession>
    <name>A0A0R3WN91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2216</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000858">
        <property type="protein sequence ID" value="VDM19273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN91"/>
    <dbReference type="WBParaSite" id="TTAC_0000222901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000222901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000222901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000222901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16277" checksum="4133F80378CD176D" modified="2016-01-20" version="1">MITPKNHRSPLRKSSEAGRVGGRMQTRTNRFAMVCPRHTGYIKKASKVDNHRTTTASLMGQLQIAFCLNVVRWRLWHYLWVGMLAFLEVTEVDVVEKSFETSIQTLETHFFILPHAIFTLVKVAFTNNCKCNSALSHPDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNW5</accession>
    <name>A0A0R3WNW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001084">
        <property type="protein sequence ID" value="VDM20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WNW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000245301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000245301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000245301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10314807at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000245301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19119" checksum="FA74D7BAEA21E68A" modified="2016-01-20" version="1">MENVALKKRYVANKILLLLSAQAAAIPERLVLPSLSVSPRGQHQESAYFFTSTPHIDTASLSCSSAAITTIHLPAPLEAYLVEQIPSKAVRGWQEEQVRQWLAEHSLEHYAHAFACINGLQLYELAWQRIRGCDSFFRNLSFGMHMPLYEQLLLSSALASLHNYPDPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP22</accession>
    <name>A0A0R3WP22_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAT2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2497</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001142">
        <property type="protein sequence ID" value="VDM20227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP22"/>
    <dbReference type="STRING" id="6205.A0A0R3WP22"/>
    <dbReference type="WBParaSite" id="TTAC_0000251001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000251001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000251001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10491905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000251001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="34984" checksum="F9E8F80BA39574DC" modified="2016-01-20" version="1">MNGDLTPAEACELKASLGRLNGRSPGPSSSPTVSPSVKVANQPDNVWTARKLAALGGYAETPAANTATTTNMNSGKSDRIGEKPNHISSSAVAAAPGKLNSVTSDTASSKQGIVEKHKKTSKNGDVLKQKGNLESSSGDKRTSKKDQQQNRGAPTLSFTTTPSANAATTTTLDVTETASTFLPNTVQHPYYSAPPFYTTGTPHPSPFFPAPPHTHFGPPPPPPPCFIPPPLPPYFQQTHHPPAQPPPPYLFSPANPAAVVAGAPYLSFQLPPPSITHGLPGPLHPAAGSVSTGTPLLGVPHTLPFVTPTTASPTTIGIAEEERNAIVRAISKISPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPQ9</accession>
    <name>A0A0R3WPQ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2734</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001443">
        <property type="protein sequence ID" value="VDM21018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPQ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPQ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000274901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000274901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000274901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282356at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000274901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40197" checksum="39F1243249EE719D" modified="2016-01-20" version="1">MRIKQEMLPEHNLSIYLLFVYLLVSAFLIPQSACRTMEVSFVACCEVGINSTHEMELDTLIKDSNSDECIAINQVEHIFQEVANINAELPEDRMAKCLQVKRGCFYAAKANIFCENAARSIYSSDDKLTPISHFSPDLLKSPRDCCKRHNRLPALDVVSDDSMDFDINGVPLCCTVKGYEVPEDLDPFANAIASRSSEELHERPLNSSTTKSTSVSVIVSVPSITSTVKQSMSTNSDNTKSYTEYKNFELSTTTVDSTRYSHSYPYATSPPPPTSLSDFPLPSHSTPPIPQTQNTAEVELVCEPGFTWNPEKQLCLHTLARCPKGMYLSVSQSKCLPKIGDRFNCPPGYEFRNDVNGCEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ08</accession>
    <name>A0A0R3WQ08_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001566">
        <property type="protein sequence ID" value="VDM21283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ08"/>
    <dbReference type="WBParaSite" id="TTAC_0000284801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000284801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000284801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000284801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="55" mass="6327" checksum="050C1EAA6BE428F0" modified="2016-01-20" version="1">MCVQWTGICEKGKLHFNTNSGQVGRRCQKRIKTIKLPSNHQCFTTKGLKNMSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQF0</accession>
    <name>A0A0R3WQF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2975</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001757">
        <property type="protein sequence ID" value="VDM21658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQF0"/>
    <dbReference type="STRING" id="6205.A0A0R3WQF0"/>
    <dbReference type="WBParaSite" id="TTAC_0000299001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000299001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000299001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="1">
        <location>
            <begin position="70"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000299001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="51105" checksum="B4B90F8857EABD44" modified="2016-01-20" version="1">MEVKGTSINKTERIDVYQNNEFPLKYRKFLRVVSESSELLNSTTEFKVPAINLEGDEYALLQNEKIMGVIESTVIEWRYKMQEIIEELRSRSTQGEGPLAEIEYWRDRTASLSRLVEQVAQPQIKRVLYLYALKERIPPNSVFEMLHRCYFEATDNTKLLALVERYFKIITYGTNLDDIIESLCPLMQALQMIWIISPYFNKEDRMTVIFERIAWCLCDRISKMLTPQELFNLPLEKMIVQIKSGRRLLESWKSTYMARRADIEASGREYRWEFDKKRLFAKSDYMIGVCNDMEDVVNIVKEYKTMFGPEIKSMFSNQKHFDLLTENVMGLLKPFKSLQFDPFLIENKSTWLNQMTQFRMEVMALDTDAKSCLEDSFRTLHSSSKAFRVLQRLLENHPRKEIAQLFEERYTDILDRYDKELRLIETTFTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQT2</accession>
    <name>A0A0R3WQT2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3107</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001936">
        <property type="protein sequence ID" value="VDM21964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQT2"/>
    <dbReference type="WBParaSite" id="TTAC_0000312201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000312201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000312201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10569074at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000312201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31721" checksum="B0830280A333B733" modified="2016-01-20" version="1">MAPIHKLNPTFDLPFRQPPSVHLHYSPTNNFGLLVFALTDAQSMGITPPPPPPPPPPPRVQGKDAGAPALAQLCLLFLLLLLLLLVPTMHKKAHTDPFKLTLFKAKRHAITGSDRLIALQRVKCTGSSVCPRHSSIINSELFVYAKVTSLRAFEEEEEEEEEGSPFHWPMQQHPISLFTPKSRAEIHSNRRNQLVTVERKRDFLSTFPIFDSLSGGATEKSLLWRFILFRKGASQLQPSIRPLLERQVTEQANQLLRNRPALSSCAAADWLLDAFHLEKNAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU0</accession>
    <name>A0A0R3WQU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3115</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001948">
        <property type="protein sequence ID" value="VDM21984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000313001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258311at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15468" checksum="B427CA60985A54AC" modified="2016-01-20" version="1">MVGLVLIKVEVVARPLGHPALAIHRRYPATAPRGSFWLLGFPPRPVHPSLDDLAVTVLRHGRHIDAVLGVDARSTCARAVWNSQRRRLPPPGLHVAGLQAHATTPSRSSSDLNNPPQPPFPITLLPTLLSSPPISYPYLHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRD6</accession>
    <name>A0A0R3WRD6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor RBM22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RNA-binding motif protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS3311</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002224">
        <property type="protein sequence ID" value="VDM22367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRD6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRD6"/>
    <dbReference type="WBParaSite" id="TTAC_0000332601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000332601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000332601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12224">
        <property type="entry name" value="RRM_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000476">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057674">
        <property type="entry name" value="Znf-CCCH_RBM22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25584">
        <property type="entry name" value="zf-CCCH_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="368"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM22367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000332601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51161" checksum="BE9885F60EFFB4B0" modified="2016-01-20" version="1">MMREQYGKECKICSRPFTVFRWSPGPKARFKKTEICQTCAKVKNVCQTCIFDLEYGLPVEVRDKALRLNQQLPRSDVNREYFHQQIEQQLEASGDVTAPYGGHEFIGKAIVSSNASTGTASSDLLLKLARTTPYYRRNRPHICSFWVKGECRRGEECPYRHEKPTDPDDPLSDQNLRDRYYGNDDPVAAKLLSKYRAMPKLTPPEDCTITTIYIGGVPADITEKDLRDHFYQFGELRSVSVHYKQHCAFLQFTTREAAERAAERSYDRLILRGHRLTVNWGKSPAALAAASAGISVTGVMDVAPLPPVPGLPLPPVPPPPSLLSSVSVSSVCPMPTIPGPSGAFFSAPPPPPLPMPVVQLAPPVVDPNAFMAGQRGPLPPPLLSAPPPPPPPPPAVQREEGEMGKVEKEATAEKGEERPVLLDQPPSLPQSPQPAVAQDLPSLGIHYPSQNPQRMGSVPQSQRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRR6</accession>
    <name>A0A0R3WRR6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferritin</fullName>
            <ecNumber evidence="9">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS3440</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01002437">
        <property type="protein sequence ID" value="VDM22631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRR6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRR6"/>
    <dbReference type="WBParaSite" id="TTAC_0000345601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000345601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000345601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="2 9" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="10">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000345601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19929" checksum="A69F6EF5C3A35885" modified="2016-01-20" version="1">MNLIRQNFNEECEAGINRQINMELYASYLYLAMSQHFDREDVALPGFRKFFAKASEEERQHAIKLMRYQCKRGGRIVYQDIAKPQKSEWTTGLEAMETALKIEREVNESLLALCDVAAKNNDGHFNDFLESEFLGEQVNTIKELADHVTNLRRCGPGLGEYIFDRETLRGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRY9</accession>
    <name>A0A0R3WRY9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3514</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002563">
        <property type="protein sequence ID" value="VDM22782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000352901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000352901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000352901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000352901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16552" checksum="1FD4651012D3C0A7" modified="2016-01-20" version="1">MFSILPFSIPYPPNTLLPSPHSKSTPQTLLPTVTHPPPAHHPITSLHSFANAPLLPRLSLVTPSATTWVYINPYTSFLLRRLQSLNLAALPAPLTYHYITPPPPLPHPPPSMSCPHSMHPLTSHALTSCINLLPTSISVEKADSKPSHPQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS65</accession>
    <name>A0A0R3WS65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dopey_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3590</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002691">
        <property type="protein sequence ID" value="VDM22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS65"/>
    <dbReference type="STRING" id="6205.A0A0R3WS65"/>
    <dbReference type="WBParaSite" id="TTAC_0000360501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000360501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000360501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000360501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27434" checksum="47FA96248D310D6B" modified="2016-01-20" version="1">MRLTKASSNFESDPKYRSYSIAIDKCLKSFEYSNEWADLISSLVRLMKLIQQYDRYDVIPEKRLLGKRLAQCLHPALPPGVHCKTLECFDLIFRIMGPDHLAADISIYGPCLFGLLGPSAMTVKPLLFNLFETYFLPLGDKLRNAFLGLLQGLLPGLEEGSEFFERGNNMIEKFCQVVGPEFFYTCLWQVSFNHISISSKICLLYLNSTFKASPVPDAEFYTHNYYRTQGLPLHLKNNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTE9</accession>
    <name>A0A0R3WTE9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4024</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003504">
        <property type="protein sequence ID" value="VDM24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTE9"/>
    <dbReference type="STRING" id="6205.A0A0R3WTE9"/>
    <dbReference type="WBParaSite" id="TTAC_0000403901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000403901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000403901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10004495at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF131">
        <property type="entry name" value="LD05287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000403901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18654" checksum="4C168CFA7990BD54" modified="2016-01-20" version="1">MNVVSPLRNCRVTVPENSVTPTPAEDSETKVAPKPGSTITGTDLTEPLQMEEGEKAEGEEEDDSMPPNLGTPHHDSPAPEMPLLQAGNGRPEDVRLWTVDHVADWLREQGGFEKEAEAFRHQDIDGTSLLLLKSMSLLTGVGIKMGPAIKICDRIKHLQLLQARVESRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU16</accession>
    <name>A0A0R3WU16_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003989">
        <property type="protein sequence ID" value="VDM24503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU16"/>
    <dbReference type="WBParaSite" id="TTAC_0000425601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000425601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000425601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000425601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9416" checksum="0D0CDDDB1E48D118" modified="2016-01-20" version="1">MQKKSRGQAEEEEGEGEGEGEEAEAQEEEEEDEDELVDICDRAVDEVFPSGNVPERDAESTVSLGKPRFGVGWRRYRLRWLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU43</accession>
    <name>A0A0R3WU43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PHD finger protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS4269</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004049">
        <property type="protein sequence ID" value="VDM24567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU43"/>
    <dbReference type="STRING" id="6205.A0A0R3WU43"/>
    <dbReference type="WBParaSite" id="TTAC_0000428301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000428301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000428301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264176at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM24567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000428301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51198" checksum="2CC71602E436E6B4" modified="2016-01-20" version="1">MALHPKADTLIHRSSSINAPAPISSQGRRKMQVPEPLSDWLVGYFHPESSPAEEYLWSAKFFGHSSVSQLTYTLVYLLGKILCIRSGAELRAMHLWNTLKLFPIHKLPQHNEKVVMKYELHYTLPPAPPVPPPVLYENSKRLLSLRERARDNRFIVILDHILVKTQKGFVIKHSAKNNHQRCLVCLHALLLQRRSCSKRALRVDDYFLSWADSSPSSRFLIDPLSDVALGTIVHDIRVILTSLQKYLHRGSLPPETDLWNHFVHDQQFRANSSQQLRPMVVEHGEECNIPLDLSVRGRAHPKCLDFWPEVAERARNGAWQCADCKSCSVCKNKRGESVILICDACDKGYHSNCHSPVVLEKSTDPTMPWICSECKAEGCCARVGNVSTSAPVSTPSSADSGVSSLVISTSEGVTNASSVNSKPDQPPSTMMATGTTGSIKVPSPEPIEYVSFTPFYIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUN9</accession>
    <name>A0A0R3WUN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4463</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004508">
        <property type="protein sequence ID" value="VDM25009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUN9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000447901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000447901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000447901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000447901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15523" checksum="938B39C530E40C65" modified="2016-01-20" version="1">MPAFGLDIAHPASVRTYRVTVATGQQSVENLDSNVHINIFGSMGDTGIRSLRKKGAFSRGKVDEFLIEAVSLGRLEKIRIGHSGKTVTPTWFLDRVTVEEVGNSANKVVFEVHNWLATRGLDGVCEEELYPTQWTESEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV68</accession>
    <name>A0A0R3WV68_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4643</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="UYWX01004948">
        <property type="protein sequence ID" value="VDM25350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV68"/>
    <dbReference type="STRING" id="6205.A0A0R3WV68"/>
    <dbReference type="WBParaSite" id="TTAC_0000465801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000465801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000465801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000465801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="35427" checksum="C942F10CCCA4E7E4" modified="2016-01-20" version="1">MRYLGPPVDMWAMGVLLYYMLMGFLPFRGRTVGQLRKLILETSASGTFPVPPRVSEGAAELIRKLLSRNPKSRPRAAKLIEEATKASALIRPLSMDRMVAVGSASSSWCCRSEPWLAHQVFPTPYPKVFTTQSVGGLGGYLLLADAGRKASQIILSTTGKGRSSPPSVTKASAETSPQHRPTPRIDITRADSTANVSVSGESTATASKALTHLSASEEAIAQSEIEAAKLLLQLGISSDHLSVPRNNDARNSISGAYRIMLHQLQRYRRLSNLPPFQGGNNSNSGSVEAASVEGAKSPTSKQKVRMKKSASDIPPTSSHRKSADKSCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVB6</accession>
    <name>A0A0R3WVB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transgelin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4691</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005097">
        <property type="protein sequence ID" value="VDM25454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WVB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000470601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000470601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000470601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000470601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25198" checksum="F2BCF3D55676B681" modified="2016-01-20" version="1">MSQVINTLMQLGTECQRNGFQGPTCGPRPTNKQYRQWTEQQLRASEGMVCLQSGTNKFASQKGMTFGGVRHAADIKADDISLESQGICSLQMGTNKFASQKGMSFGSVRHVADIRCDDVTKEGQGVITLQMGTNQCASQKGMSMGGVRHGADIRCDNMSREGQSTITLQYGTNKFATQSGMTSIGAVRHIADIRVGAMSAEGASHLGLQMGPGAKQVATQSGMTSFGAIRHINDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVD9</accession>
    <name>A0A0R3WVD9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005155">
        <property type="protein sequence ID" value="VDM25509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVD9"/>
    <dbReference type="WBParaSite" id="TTAC_0000472901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000472901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000472901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000472901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="7915" checksum="3159CDA030C931E1" modified="2016-01-20" version="1">MIGSYQLLTVAVDGGLCGDFDEEINDDFGFRLEVAALGAAFVVLEEGDLRSSCRVALATGCLAIDAFVAAASGGGRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVS8</accession>
    <name>A0A0R3WVS8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4853</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005493">
        <property type="protein sequence ID" value="VDM25766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVS8"/>
    <dbReference type="WBParaSite" id="TTAC_0000486801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000486801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000486801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000486801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="34417" checksum="15150C4C3CCEE37C" modified="2016-01-20" version="1">MALTSLANILNLISFVSSYWIVSINKENFGFVRLGLWEVCFDNFIFAGDYISKAYDGCWYVFRQEFKYIRFWINPLACLTVITIMMGLMSKDRMWLPFSDRNTVGWGLGFAATGGILMLLSIFCLIVDQVAHYSEQIYYKLLEEGGFLSTQPIPPDFTSGVGEMSTRKLPIGASAVGTTSESKLGGVPSLFLTASLPSVAGSRESGGRHGGTGPAARISSVLGSAKNALLTHYGEARTTIPGMSLRSEVPATSGALASAKLRQDLQTERSTRLASTAAAVGAPSSTYSTRSPSLVGIGGKQEKPVIVYGTSQGNILKDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW61</accession>
    <name>A0A0R3WW61_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4987</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005868">
        <property type="protein sequence ID" value="VDM26004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW61"/>
    <dbReference type="STRING" id="6205.A0A0R3WW61"/>
    <dbReference type="WBParaSite" id="TTAC_0000500101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000500101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000500101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10608615at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000500101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46813" checksum="E5EB4653A53AAB7D" modified="2016-01-20" version="1">IEAAEPFHGTVELNGTNFRGTFRHSCLQNRGPCYVVIKDRLLDAGQHQVCAKAVARNGQSAISCLPVSIAEQQGKLQLYVDGSGAPLNGRTILRTRPISGDYDPRLSYSLYFGDGSPPVTGSNLDAMTLFAHNYTTEGKFTASMQFDNGQHLTCVVAVAHPIEEFRVLFPNGPVAVARKSINATVRLISSGPVSIEVGGEHQWFTLVPPAEGVYHANVTAYNLGFAITIPVTYQGQLDQFDIRIHLQQRNSSTTPRIVGAVEFPNYSGSRPVPLGFRLNAMCVPVKGAPPVAQVIHVHEKEKTFNFTLPPLGQFECTFTGQNDVWTTRPQNHAVNVTIPLILGGIGIFAREGAQIVTGCGPHYNAFEQGTSITLSVDIIQGDTEKVQWHLTKLGNLRVHFERVERDAKTIIFQPLDVSSASTESPVNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW72</accession>
    <name>A0A0R3WW72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3752 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4997</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005907">
        <property type="protein sequence ID" value="VDM26032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW72"/>
    <dbReference type="WBParaSite" id="TTAC_0000501201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000501201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000501201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000501201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7175" checksum="E5646784DA0E8BA1" modified="2016-01-20" version="1">VAKKKKKVEKGKKESATAGPTRQPFDRERDLLVSRVDPLKRRAIIERSKQLSSKFAHGGQKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWA7</accession>
    <name>A0A0R3WWA7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid adenylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5032</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006014">
        <property type="protein sequence ID" value="VDM26111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWA7"/>
    <dbReference type="WBParaSite" id="TTAC_0000504701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000504701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000504701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000504701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11756" checksum="9F17229BE7079F9F" modified="2016-01-20" version="1">MANLRFQYWEDFVQALTGSQNLTSGMVQRSPIEAELDWARNRPVDVAFRDCSELEGYAEATNAPIHYALAEAFGVSSLTFMLVVFSLTKHAVCVTIILLNSDVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWB7</accession>
    <name>A0A0R3WWB7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5042</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006041">
        <property type="protein sequence ID" value="VDM26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000505701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000505701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000505701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000505701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12853" checksum="891E6DA526866140" modified="2016-01-20" version="1">MAYRKLLHLSDHGDVRLSQRPSRRVSGSHDINSMQTRNGPRTLTHVAIRLILALEAVTKEALVSMLLAHIVALPPHISFPHSVAVGAIRQVIKWPHFCATISASHPINLSCWTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWT4</accession>
    <name>A0A0R3WWT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5209</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006615">
        <property type="protein sequence ID" value="VDM26477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000522401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000522401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000522401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000522401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28160" checksum="8B497FE68E198E05" modified="2016-01-20" version="1">MQLKDLSGSERKRYLASVGVAQEALNAHRVVTSFGLEAFYSDLFLMKCGRPIPLIDWSNIFFSTVSTVAQSMQYFQMAASFSVGATLLRQKDIKTFTVFRVFTLISFSAQGVGRAASFLPDLKSANTGARQIMSLLERQSQMDVESGDRPQEPFSGKIEFKNVEFSYPDRKYVKVLDGFSHTVEAGTSVALVGQSGCGKSTILQLIERFYDADNSEKLKEGVFMDGKSVKDLSPDWIRKHIGVVLQNSDLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX33</accession>
    <name>A0A0R3WX33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5308</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006977">
        <property type="protein sequence ID" value="VDM26664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX33"/>
    <dbReference type="WBParaSite" id="TTAC_0000532301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000532301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000532301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000532301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10803" checksum="A9771A2BFACA02C4" modified="2016-01-20" version="1">MAVNAELNEESLFAHNYLRERHGCPPLEYDEELAKSSQAFANKLANSSRLHYYYPTEYGENVAYRVRSRDANLTGRLSVFHFVALVNHLKVVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY02</accession>
    <name>A0A0R3WY02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5628</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008296">
        <property type="protein sequence ID" value="VDM27345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY02"/>
    <dbReference type="STRING" id="6205.A0A0R3WY02"/>
    <dbReference type="WBParaSite" id="TTAC_0000564201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000564201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000564201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000564201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13765" checksum="91331DE23E253BDB" modified="2016-01-20" version="1">MQRPTASELHQQAWEQEEQRRRRANAERIAQAEEEAVAAAAAAAEAEVVAASIKLSAAARRQQEEAQRLLQQQKAREAAMREAAANLADLKLPPTARWGAVSSSNVGGAPTSMADIFASQMQEEEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYF3</accession>
    <name>A0A0R3WYF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5778</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009019">
        <property type="protein sequence ID" value="VDM27651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYF3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000579301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000579301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000579301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000579301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9549" checksum="A1AB90613D743FBE" modified="2016-01-20" version="1">MQYAEEQNLKRCLERLLDEKVRHPGPTNWDASNMEGRILQTIVDYFINEAPPAFELGTNHSVGHRGPARQQGWCRGTANQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYP8</accession>
    <name>A0A0R3WYP8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5873</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01009467">
        <property type="protein sequence ID" value="VDM27852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYP8"/>
    <dbReference type="STRING" id="6205.A0A0R3WYP8"/>
    <dbReference type="WBParaSite" id="TTAC_0000588801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000588801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000588801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0401">Integrin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM27852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000588801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18437" checksum="D66A6938A9871282" modified="2016-01-20" version="1">GNQDLQCDPPFLYKHILSLTGDFAEFERKTILSRPSGNLDSPEGGLDALLQVARCPEYIGWRKNARKIVLFATDGGFHLAGDGRLAGLIKPPPKTCQLTFESDRFNKSLKYLGWHNSVETDYPSVGEVLLVELEEFELGFLILLNRYDRFLDLLYQYFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYV7</accession>
    <name>A0A0R3WYV7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009802">
        <property type="protein sequence ID" value="VDM27997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYV7"/>
    <dbReference type="STRING" id="6205.A0A0R3WYV7"/>
    <dbReference type="WBParaSite" id="TTAC_0000594701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000594701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000594701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275668at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000594701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13313" checksum="0CCE4F6435A21E26" modified="2016-01-20" version="1">MEGDEVVQLPDALIAVDGSRVYEPLIMFNYLIEDDDVAFSLEFQPQPLPPQACPQFLVVARHIFPPNLAAQSDGRGEDFWAIIPPQTSVCSRFPFWSFGLHFLLHFKPFLTCCTNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ57</accession>
    <name>A0A0R3WZ57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010313">
        <property type="protein sequence ID" value="VDM28252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ57"/>
    <dbReference type="WBParaSite" id="TTAC_0000604701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000604701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000604701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10583056at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043785">
        <property type="entry name" value="DUF5727"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18997">
        <property type="entry name" value="DUF5727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5727" evidence="1">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000604701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14823" checksum="4E852CD05E109249" modified="2016-01-20" version="1">MEVKLERVTVSTSATRMCKLIDLVKDEKADLRVFHGVFPTKTNVTRESFRLVGNTTYVIVSVDYTQNGTSPEVAECNRKLSTARIASSPQRTTPHHTSPYLFTYSPPTCSTDNLNGMCLAGKLKCLCYLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZZ2</accession>
    <name>A0A0R3WZZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6389</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000640401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000640401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000640401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000640401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35011" checksum="375502845F7D89E3" modified="2016-01-20" version="1">MRTRAIHQSASVSRPAQLDSENEEGWTCALSKVSYFRLRLGMRRRLKAKGYTAPLSFTLPVPANPGNHGRRTVFMLPDDSPSVLSSKFGAILASFLRPTSLVAVVLAQLRPRFSCSAGFATLLCLGLGNPAVDAASLRQLAFLSALVQMSEGIFSPGKTFVYDPLLKTTSRNFIRELGFYILSSNLEGQYQLPRGHPTLVFLPHCPIALAEGLVASNWHPDVLNRLTFLSCPLKPRAGIAEVPCIAHLQPFRSYSLLKTEGERDFEGIRIEWFHIPAGVDLGAAKNNEKVATSYSDLLTFEAIPSFIDGEDTKSTDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0I1</accession>
    <name>A0A0R3X0I1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6626</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0I1"/>
    <dbReference type="WBParaSite" id="TTAC_0000664101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000664101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000664101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263821at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000664101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61700" checksum="B94458CFFA2E3AE2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0S7</accession>
    <name>A0A0R3X0S7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-complex protein 1 subunit zeta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6744</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020320">
        <property type="protein sequence ID" value="VDM31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0S7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0S7"/>
    <dbReference type="WBParaSite" id="TTAC_0000675901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000675901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000675901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000675901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="547" mass="59870" checksum="46B0BC80D2B03F1F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X166</accession>
    <name>A0A0R3X166_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6904</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X166"/>
    <dbReference type="STRING" id="6205.A0A0R3X166"/>
    <dbReference type="WBParaSite" id="TTAC_0000691901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000691901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16131" checksum="CC3DE0859FF2FFF3" modified="2016-01-20" version="1">MQAPLACENFLALCASDYYKGCIFHRNIKGFIVQTGDPTGTGKNGQSIWKQKFKDEFDDSLKHNTRGIVSMANNGPDSNGSQFFITYSKQTMLDMKYSVFGKVIDGWDVLDELERAPVEDKTYKPLTDIHIQDITIHANPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Q6</accession>
    <name>A0A0R3X1Q6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Noggin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7148</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the noggin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020349">
        <property type="protein sequence ID" value="VDM31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Q6"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Q6"/>
    <dbReference type="WBParaSite" id="TTAC_0000716301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000716301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000716301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950649at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.520">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008717">
        <property type="entry name" value="Noggin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494:SF6">
        <property type="entry name" value="NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05806">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133169" evidence="7">
        <location>
            <begin position="32"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000716301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50949" checksum="8C64999CAC68347A" modified="2016-01-20" version="1">MSMHIGEARQRSFQHPLRLLCLLVSLTAISATFNSSNDHSGGLPALFYQKRSHSGSILTSASSSSSSSTSSSSSSKLMSKSGEPVGSGGMGLSLSNRNHISLGHLTKKETPISSQTSNLDVETSSSRSMRVMGQPINPNIVSHLHPDVSPRKIHRLWRLLGGKEDKYWTSEEPPRVLRQRGVSGMHSDAGTHPPGANSIESSLIRKANALNMTFRDQTGAQFLLPETQIQIFRNWLIEQATCEMDFIWKDMGSLYWPRWIRMGVCLARLGSSCSWPPGMKCQPSGSRVLRLLNWNCEDAAQAESSGVSMLSRKTRSLHQPTINLRYHLQEPASRLQIRQPYAQQTSPMWRYYRMGRRKGRRDASMPMDPAQQEEQRARRARRLIEKLSVTASGYRCSWQVQKYLISDKCTFKHSVSDTTLTATRFTIFPCFIGLNKQMHIFTNSRTNHTFASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2X3</accession>
    <name>A0A0R3X2X3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP18 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7651</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020391">
        <property type="protein sequence ID" value="VDM32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2X3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2X3"/>
    <dbReference type="WBParaSite" id="TTAC_0000766601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000766601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000766601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000766601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46207" checksum="D1EFEF33902180CA" modified="2016-01-20" version="1">MDVLIAEVARKRKSLQDNELVTKEKKYFRRSDLAKAEEHEYKTKYKYRTNIVLAEDDASYSSLLQSTPEENLLLKKMEREREEKAKGKLMPRREVIKLLRERNQPIRLFGESDFDTFQRLKRIQLLEPESKGLRNDLLAAMDKVDEDEDEAVFGEVRNNAATSATSDGGANLEVAIKKDYISPEEMGVLKVTLSSYVMMREPNATDDATAVAASFARASDMHHVNKTNDRAAREEVSDHVLRYLKFLLSQWGTHLNQRSREVKQSYSGKMASATYNQTLEYIKPLFKLLKTKRCQDDILDSLVKVVVLLMDRNYLKANDAYLDLAIGKAPWPLGVTNHGIHQRTAQDKIHAKNVAHVLNDETQRKFIQGIKRLMTRAQEFFPTDPSRCVNYMKLPSSASDTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X323</accession>
    <name>A0A0R3X323_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7706</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X323"/>
    <dbReference type="STRING" id="6205.A0A0R3X323"/>
    <dbReference type="WBParaSite" id="TTAC_0000772101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000772101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000772101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000772101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="66040" checksum="D45A21978178ABD5" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X352</accession>
    <name>A0A0R3X352_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7738</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020399">
        <property type="protein sequence ID" value="VDM32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X352"/>
    <dbReference type="STRING" id="6205.A0A0R3X352"/>
    <dbReference type="WBParaSite" id="TTAC_0000775301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000775301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000775301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="64"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000775301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27534" checksum="88F987ABB6B0533C" modified="2016-01-20" version="1">NQFALQDTEFNAILRERGVLPPLPKSKEPTPPPSPESQRRQLMQEMSYTQLTEELETLEDRGCDDLDEDKKFLELYRQKRLEEMREAAKKAKFGFYGEVTKSDWVESVNNAGEGVYVVVHLAHKGNEKCAVIDQHLRTLAALYPAVKFLRGEASLCVPNFPDSNLPTIIVYYKGDVKAQYVGSGALGGHPCSIDDLERLLTKVGAISVAEADGDGENHRVERLGSVTRIRTGNRSHRRQSTDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3A0</accession>
    <name>A0A0R3X3A0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020406">
        <property type="protein sequence ID" value="VDM32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3A0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3A0"/>
    <dbReference type="WBParaSite" id="TTAC_0000781201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000781201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000781201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133177" evidence="2">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000781201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="37935" checksum="38A0FBA69D17CBF8" modified="2016-01-20" version="1">MSHPLLWILPWLLSAFIGGECVRYSRFDIAISFANSSAKFSTSVFNLSVANYCVGGVPNVNDGAFEYHKVYQGDLVRLKWHSTQSENESPNSGCFISPPPRMQHSSWIAVIMEDMPQTGCSQFALLNYTSSLAGAVAILFLHDAQSAFDFSAIEASFSSPPSSPLRRKAAWRQRRTGRGLVSMPPLLVSLPMDMFPDLPTQLAVASSFPEVAVTGDIELFAELPSLPTTVHTTGANTASDLSSSLLLLLIVCVLFLLLGVLLIPARLGICFWQRLCFLSLVNSSKSRRSRKLNAATKKVLKQLPVKCLNQVDPLISEGFDQCAICIEVFKSQDLIRSLPCRYSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3P8</accession>
    <name>A0A0R3X3P8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7970</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020426">
        <property type="protein sequence ID" value="VDM32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3P8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3P8"/>
    <dbReference type="WBParaSite" id="TTAC_0000798501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000798501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000798501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="141"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000798501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47125" checksum="2563C247CD474B75" modified="2016-01-20" version="1">MKSIIARQIFDSRGNPTVEVDLTTNKGFFRAAVPSGASTGIHEALELRDGDKFAYRGLGVSKAVDNINRIIGPALCQRNFAMANQEEIDMFMVKELDGTENKSKLGANAILGVSLAVAKAGAAEKNVPLYRHFADLAGNRDIILPVPSFNVLNGGSHAGNKLAVQEFMIMPTGATSFKEAMKMGSETYHALRAVIKNKYGLDACNVGDEGGFAPSIQDNFEALELLREAIESAGYTGRIKICMDVAASEFYKDGLYDLDFKNPESKREDWIHSEKMIDMLNSMVDKYPIVSIEDPFDQDDWNAWINYTSEAGIQVVGDDLTVTNPVRVQKAIDTKACNGLLLKVNQIGTVTEAIKACNMARQAGWGVMVSHRSGETEDCTIADLVVGLRTGQIKTGAPCRSERLAKYNQLLRIEEELGLAAKFAGENFRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3S1</accession>
    <name>A0A0R3X3S1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein BCP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7994</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020429">
        <property type="protein sequence ID" value="VDM32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3S1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3S1"/>
    <dbReference type="WBParaSite" id="TTAC_0000800901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000800901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000800901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000800901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27565" checksum="49E7DFE7D9C9142D" modified="2016-01-20" version="1">MSSKKSKRSEESPDEDVIELDLEGFSPQLEDRDGIIQLLRQHMPKDSNVSLGELADYIINQSSVGTVVKNTVNEADAAKDDDDEIIFSLTTVISLSVPTVARSSVVSEIRTFLSSCISRAEPSSSDSKILLKVLMGQASEKPGLLINERLVNLPPAVAAEAVAVLPQEILTLPEEERPTHLILMTRAVKSKDADELIYIQPEMEIVRKVAFAVVEAESMDVAVDGESETITYVIMAIEFSSIPEILDLLAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3S6</accession>
    <name>A0A0R3X3S6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WIF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8002</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020430">
        <property type="protein sequence ID" value="VDM32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3S6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3S6"/>
    <dbReference type="WBParaSite" id="TTAC_0000801701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000801701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000801701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133173" evidence="3">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="4">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000801701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="265" mass="31183" checksum="B0131F9F4A83DDBA" modified="2016-01-20" version="1">MHLSAVSLYIHLLLLEVFMGAQGQLNLWADRKLVARIIESIPSNGKDYSSLKCPRQRPDITQHIPPQLFLVLNGHILQEVYDKILHSVHRPLPPQIEIIRLKWRAGLERLTYNISMISLNKTLLFDPLLNVANYGIIPAMESDVQITLACTGKMTGFAAFKLHLDIRREFEGLRKIPRIDFVAQKYCLSKRKSLLQLSHKMNERFRKFHIKCDCRAQCQKLFPPMYFTKTYRKKCNQRCRRDLSSKRGTSRYNYYFHQNQRQHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4K4</accession>
    <name>A0A0R3X4K4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING/FYVE/PHD zinc finger superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8332</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020485">
        <property type="protein sequence ID" value="VDM32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4K4"/>
    <dbReference type="WBParaSite" id="TTAC_0000834701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000834701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000834701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000834701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16180" checksum="E7B9B51E9736A1EB" modified="2016-01-20" version="1">MLQMVESRMKALGRLGRLAAAMNIPARDRLGGKGGHPIWTDCVQQTEEEWDCELCPEDRGRQLGKAALWVQGGAMYATGAASVTFLRKLKRDRGQSVPDTTSERTEINKRVDGSDRQVEVGQWSGSVEALNTSVFIGGGSLTGLKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4M9</accession>
    <name>A0A0R3X4M9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8361</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020490">
        <property type="protein sequence ID" value="VDM32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4M9"/>
    <dbReference type="WBParaSite" id="TTAC_0000837601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000837601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000837601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235294at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cystatin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000837601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26881" checksum="264245615F81C758" modified="2016-01-20" version="1">MVGGITPLTKEDMNEVMFQEALTEVMKNLDEANECHSFRLVRVIEATKQVVAGMKYAVKLEVAPIYSNENDGECSKACYLGLSGNKKAVATVIVQPWRDPKHYITFNPNNDGSADFSKNGELISSCSLPEWTTLSSGEMQSEQFREVLQKSIEKLNETARRCFRYEFLDLIEGKRLMASSPKYEWTMRVKKIYDESMPSCKGTCADDCSGIEIYRASALASPLEGGTPEILNIGYQGPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X596</accession>
    <name>A0A0R3X596_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8606</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020543">
        <property type="protein sequence ID" value="VDM33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X596"/>
    <dbReference type="WBParaSite" id="TTAC_0000862101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000862101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000862101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242043at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000862101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39066" checksum="B65AA34452BEE64D" modified="2016-01-20" version="1">MYSRIGFFRAAFPRNVCALHQNIKPHSKLLIKSASQVEVSRLLECGAESSFVVIPDSPVFRVDNGCEIVQTVELDPRKGGVNKIQIPARRIAIEIEHNSSDPISFVNYEGPQAMIRSIGPVNYAKLRVSDFSIKSGGNVVGSGYLEGNFDLSFKADNITGSSIGIAFGGTNFAVHSAYCETLNLNWITPEEPPDGVTPVELPPLSVYFGTLRGYATIEIAGDANLNIGSFEGSLYLRQRFGNVAVHIGGPCPLLEIDVAEGNVELSLPLSTVGGEVSGVIEIQAPEIDVDRDALPADCLDNWDLGEVAEAHTFYANFNKPETNCETLWRVRTLRGRVKLTGASWADAMARCIERTTATMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5H0</accession>
    <name>A0A0R3X5H0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mth938 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8698</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAMDC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020566">
        <property type="protein sequence ID" value="VDM33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5H0"/>
    <dbReference type="STRING" id="6205.A0A0R3X5H0"/>
    <dbReference type="WBParaSite" id="TTAC_0000871301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000871301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000871301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000001">
        <property type="entry name" value="Adipogenesis-associated, Mth938 domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15811">
        <property type="entry name" value="MTH938 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15811:SF5">
        <property type="entry name" value="MTH938 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000871301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16337" checksum="007A596932AD9AC1" modified="2016-01-20" version="1">MNPSLSAVRGNAFPLPSPRILQLKWGSLIVEKVDKETGCRKTSETIKYKDAKLWPGGSQSWDWKKHGTSHRRGITLEDVIDVYGSGAQTIVLSMGKMSWLHVPHFVINEVENDGHTVIVKPTQVAMEIYNKLAECGHPVAGLFHTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X603</accession>
    <name>A0A0R3X603_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020624">
        <property type="protein sequence ID" value="VDM33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X603"/>
    <dbReference type="WBParaSite" id="TTAC_0000892101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000892101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000892101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000892101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16703" checksum="D0521F0301291074" modified="2016-01-20" version="1">MLRLTINGAENLRWCEVGAVTFRVALFNLSFKLTSTTLGQEKNLRLNARQSDVIVWVGSGAQFFKLECPRGDSNWPNLKCQSRTTEVSSQDDLPLIAPHTRALFRVWDKARGVDGREKQNEEEEDVEEEEEEEEAEECMSRPLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X610</accession>
    <name>A0A0R3X610_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8913</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020626">
        <property type="protein sequence ID" value="VDM33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X610"/>
    <dbReference type="STRING" id="6205.A0A0R3X610"/>
    <dbReference type="WBParaSite" id="TTAC_0000892801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000892801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000892801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF369">
        <property type="entry name" value="FI18813P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="269"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000892801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46012" checksum="8223A9A006B73609" modified="2016-01-20" version="1">MKHPGATAGFIVAFTFLVLAVGITAYVLIRRRRTIIHGGWNTSRREVHHTINLGKEQLLDEPRSYTQSWAGSSVAGNGLNSLHHLPSPDKPVSETGVHTSATNHIIKGNGKLQFTVAYDNNIQELQVSILRCVELPQIDSSLNTVDSYVKLELLPEKRHRVKTRVVRGSSNPFYGEVFTMDKVPLSLLKAGSLHFIVVGFDRHSRDSVIGEVVCTLGDLELNLVKEVTVTRDILRRKFSVSRMPYYHHHRHLQKLQIAIINAVKPSDKNRGMLLLSLCYLPAASRLTAVVLKAEGLPKVDLANSSGNPYVKLYFMENDRRIAKKKTHVKKRTSNPVFNEAFALEIPPNAKLEDIRLEFRLVNWERDSPSRVIGRVTIGCRGNDKAKEHWSKAIENPRKQVAEWHTILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6I8</accession>
    <name>A0A0R3X6I8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LAGLIDADG_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9109</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020682">
        <property type="protein sequence ID" value="VDM33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X6I8"/>
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        <property type="protein sequence ID" value="TTAC_0000912401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000912401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133196" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000912401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10936" checksum="DA5DF544FDBEE920" modified="2016-01-20" version="1">MVLVQRLTLLAANLVDGHEIIAASKRNGGNEQGSVYSNGHISKGAVALKLTPIQREYAVFLELLFAPYGCDCNRLDVHSEAREWVLTLNLSVLTAAEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6I9</accession>
    <name>A0A0R3X6I9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020682">
        <property type="protein sequence ID" value="VDM33831.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000912501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000912501"/>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000912501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13695" checksum="2F2CA6C3E55A824B" modified="2016-01-20" version="1">MFIHLEGPKKTEEEEEVYSQKMGAERRDMDYFTKHTFLELVPKTRLHPSDQESQYFSKNQKESPSDPLLKAPPRRGRNHEEEETKLNENSALPSRHLHFLHRENKKEVLKVAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6N4</accession>
    <name>A0A0R3X6N4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020697">
        <property type="protein sequence ID" value="VDM33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000917501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000917501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000917501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000917501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10768" checksum="1F05133DCD747FE1" modified="2016-01-20" version="1">MAVMKTLKDDDAEDRKSEERAEEEEEEEEGELRYFHLQGDTGGRHLVEGDVDHELNRERHFYPSRVGWHIIKEIGSHEQRVIGCCESAAASAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6P8</accession>
    <name>A0A0R3X6P8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9176</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020702">
        <property type="protein sequence ID" value="VDM33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6P8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6P8"/>
    <dbReference type="WBParaSite" id="TTAC_0000919101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000919101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000919101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:recycling endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="58"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="480"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000919101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="759" mass="83748" checksum="574844BE320272DE" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Q1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9179</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020704">
        <property type="protein sequence ID" value="VDM33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Q1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Q1"/>
    <dbReference type="WBParaSite" id="TTAC_0000919401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000919401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000919401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284701at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000919401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31842" checksum="1C1BFB8DFA8AB410" modified="2016-01-20" version="1">MFNKRISCIIATVMSDAEQYIEIRRINHLLPYSDQIEAYAEAATIGLRESFRRLISSSTYLCHHHNFTFDIKNFIEMFGFRFTKREFIGIVRFGLALVFCRQTDRTFRAVWADCIQFLLTNAGVFITRDELQLDWRLFRNAAIDIGMTNDVRQCKLDFKNGKPIVGILNSAKSRVWLDDIFHIWYKYPKPEISKEVISLLSCLALGCPGRIDWEPHLDRIFNFLMLIFSPEKVLGDYGETVALDIADILVFSIVPGSSTIDRLRDFFEVGQTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6S5</accession>
    <name>A0A0R3X6S5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9208</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020716">
        <property type="protein sequence ID" value="VDM33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6S5"/>
    <dbReference type="WBParaSite" id="TTAC_0000922301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000922301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000922301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000922301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="866" mass="96230" checksum="7A6117F90BAE75D3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6W8</accession>
    <name>A0A0R3X6W8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sestrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9258</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020737">
        <property type="protein sequence ID" value="VDM34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6W8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6W8"/>
    <dbReference type="WBParaSite" id="TTAC_0000927301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000927301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000927301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000927301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53075" checksum="9D5EEAE846A4B4E1" modified="2016-01-20" version="1">MNTAMLRDLQRVSLDFASRSVDSLSLLQGFSRRDFTLRTEWAQSVQRVIDSWFFGFGSPAVAGFLESYSQDSNGTTVDTSMHRNILSQIPDFARVIQTCPLRDVRDFCHAIIEDLKKKKHFIFEIPLQPSPSYSFYMDDLPHLRIIFDEPYDDDPMFSTYVLFCEYWYRWGRLDNFVQILGCHPEFLEPFIKVHQCLFTGDLSLPYPVRYYLAILAAAELRCPQLVCLFVRYFLQAGGEGSWLEGLSHAPSRWFQLKHLNHNLAHSPWKITSDDIYQLTRGDDVVGRIEKLSLSELMHAVAIVTHVHALACFAFGVAVRPELEHVCPSPYQPCIYSAATGATVTDTSSAFPTLGHGDKTTMWMNEQHYKDRQAEASKHLFKLLQSEPDDWDGRGGDEVVAENFQSYAKSTSELSLAALCEKITASDNFNLENHPVVAKFLSFPGSSFVDYLGSPFLLSVSRTPPKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7L9</accession>
    <name>A0A0R3X7L9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9529</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020872">
        <property type="protein sequence ID" value="VDM34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7L9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7L9"/>
    <dbReference type="WBParaSite" id="TTAC_0000954401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000954401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000954401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="243"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000954401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48820" checksum="B74788CDE10D8C4E" modified="2016-01-20" version="1">MSTSISSLNSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGALESLEKALSNPGEPSECVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICRFPFSAKENEVCINPYHYKRVESPVLPPVLVPRHSEYPSMGSVTAGPSTDSIRTSIMPLQAAPLLMASSYGQLTPSETAMPYNVTYPQGFTQTSPLPPATPVSSGASPPTSVPPTSDTHPVNYQEPKYWCSIVYYELNTRVGEAFFASQPSIVIDGFTDPSNNSDRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVFAECLSDSSIFVQSRNCNHRHNFNLTTVCKIPPGCSLKIFSNQEFAQLLRRTVSHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWVEIHLNGPLQWLDRVLTQMGTPRNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8D3</accession>
    <name>A0A0R3X8D3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9793</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021054">
        <property type="protein sequence ID" value="VDM34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8D3"/>
    <dbReference type="STRING" id="6205.A0A0R3X8D3"/>
    <dbReference type="WBParaSite" id="TTAC_0000980801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000980801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000980801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000980801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13779" checksum="212171DBBDA878E4" modified="2016-01-20" version="1">MQAAGEHVSSETNQPPQSQKGKRKHQRKSKKDVYTGEQTRIRRDSDQSSVKNETNDSASNLTIGNELGNPSSSKPNLEKAKGRDDNGFGMWNVNEEFSRGHPSNPHATVCPVALTANAIFELDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8F4</accession>
    <name>A0A0R3X8F4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9814</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01021073">
        <property type="protein sequence ID" value="VDM34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8F4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8F4"/>
    <dbReference type="WBParaSite" id="TTAC_0000982901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000982901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000982901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="292"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000982901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="59574" checksum="DD63FE7F48AB0729" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8I4</accession>
    <name>A0A0R3X8I4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9844</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021102">
        <property type="protein sequence ID" value="VDM34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8I4"/>
    <dbReference type="WBParaSite" id="TTAC_0000985901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000985901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000985901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133227" evidence="2">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000985901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13992" checksum="954A21BD499E2E49" modified="2016-01-20" version="1">MQSASTLICLCLLLAVASYPVFAAAAIVENARAEEKKEEEDEGVLKLASELSDVSEAKESDDVVPDVFEMERLSVPNEVEEDADVLVPARPRRRWRRINCGPPYGSRRRRRHPRPIYQPRLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J0</accession>
    <name>A0A0R3X8J0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021110">
        <property type="protein sequence ID" value="VDM34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8J0"/>
    <dbReference type="STRING" id="6205.A0A0R3X8J0"/>
    <dbReference type="WBParaSite" id="TTAC_0000986501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="518" mass="56638" checksum="E02B9C6C40B651ED" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Y4</accession>
    <name>A0A0R3X8Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9994</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021223">
        <property type="protein sequence ID" value="VDM34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0001000901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001000901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001000901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="7">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001000901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17059" checksum="D07E7DBF93E8F7F7" modified="2016-01-20" version="1">MASASSNDGTRIIYYVDEEDTPYLVKLNAPSDSVTLGDFKLALNKPNCKYFFKSIDDDFGVVKEEITDDSAKLPCFNGRVISWVRCLVSNDNCAGSSDGGTGLNAAKLAALAGAQIGDGTQPPEKNRFGEKKINGTSKKPTDECDTCTEDTESVQSGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9L4</accession>
    <name>A0A0R3X9L4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS10224</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021443">
        <property type="protein sequence ID" value="VDM35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9L4"/>
    <dbReference type="STRING" id="6205.A0A0R3X9L4"/>
    <dbReference type="WBParaSite" id="TTAC_0001023901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001023901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001023901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF126">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="57"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001023901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="734" mass="80465" checksum="45AA4F498089491C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Z3</accession>
    <name>A0A0R3X9Z3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10353</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021586">
        <property type="protein sequence ID" value="VDM35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Z3"/>
    <dbReference type="WBParaSite" id="TTAC_0001037001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001037001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001037001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001037001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12574" checksum="A18998ECA81B9846" modified="2016-01-20" version="1">MQWRVIRPPVVEKARAEEKKEEEDEGVLRLASELSDVSEAKESDDVVPDVFEMERLSVPNEVEEDADVLVPARPRRRWRRINCGPPYGSRRRRRHPRPIYQPRLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA04</accession>
    <name>A0A0R3XA04_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021597">
        <property type="protein sequence ID" value="VDM35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA04"/>
    <dbReference type="WBParaSite" id="TTAC_0001038101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001038101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001038101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001038101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13947" checksum="400C9E9C15D91A60" modified="2016-01-20" version="1">MWKKECVFSRAAIAVLMDEALKNSRICDFLSLTFPPPFHPDTRNRKVVVDVNDVSVAVEDETQGWEEEDGSRASKKEAVFAAGAAKNQDMIYVEEAEGRGERKEGKEERDRRRGPKACTVLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA28</accession>
    <name>A0A0R3XA28_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10388</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021632">
        <property type="protein sequence ID" value="VDM35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA28"/>
    <dbReference type="STRING" id="6205.A0A0R3XA28"/>
    <dbReference type="WBParaSite" id="TTAC_0001040501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001040501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001040501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001040501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26423" checksum="0989DFA46638FF6F" modified="2016-01-20" version="1">MRRILNHDVSGFKNGPETALRFGFHGKLKDLLFPEAKELHPSQRLFVASLAGAWSLTLTYPMEVMKTRMALRKTDDSNSITACTKVLYSQGGLRSFYRGYAISMLSYVPYAGLELSFFELFKRGYVEYFYGYHPGDPMPHIAKPVAISLIICSSLIPMLIIYPANLMRTRFQANTNFRPPTIISMFRSILQANGLSGLYRGFLTSLSKTLPSVTITYLTFEALMEAMGLPTLGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAE2</accession>
    <name>A0A0R3XAE2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10502</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021776">
        <property type="protein sequence ID" value="VDM35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAE2"/>
    <dbReference type="STRING" id="6205.A0A0R3XAE2"/>
    <dbReference type="WBParaSite" id="TTAC_0001051901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001051901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001051901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001051901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16822" checksum="C8E940AA9216950A" modified="2016-01-20" version="1">MCNALFVSPTFAFHAFTPPANTNATTCAMQGATLDALSQWSVEGVCVCVVRIYDHMKKAEAMDNAALDMSFKSLSPMSTMEMAYQAALSLYPSHGDGAKNAISALASAAAAAGVSSPLVASHSSVSTKENPVVELIDRHLWRSFHAYETEMVITKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAK0</accession>
    <name>A0A0R3XAK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LeuA_dimer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021858">
        <property type="protein sequence ID" value="VDM35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAK0"/>
    <dbReference type="WBParaSite" id="TTAC_0001057701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001057701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001057701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001057701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8596" checksum="CEF7D558CCE1AA7F" modified="2016-01-20" version="1">MKVATAVSTSFRLAYARTSSSPATLTFRVSLATEPIYVDSVVADNVQGAVCMALDVVRVVKERLGKEHNNSQYTTSGSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAL9</accession>
    <name>A0A0R3XAL9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SLC26A/SulP transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10580</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021891">
        <property type="protein sequence ID" value="VDM35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAL9"/>
    <dbReference type="WBParaSite" id="TTAC_0001059601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001059601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001059601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001059601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22743" checksum="BF347A3FC84FEC02" modified="2016-01-20" version="1">MKKRGRTHVFWRVVTNPIWLGVTATTVTENTIVSAYLTYAAKYLQAQFRTPAHLASIHTVPSPPSTPPPPPPPPPPPLPSNHSSYPPSAFLLITTISSRHTAPPTTALYSLSQQHYRRDKVAGRCCHNYRTFLRLFTSQGGCAVVVPSAVLGVLTGALLMRHFRPSITRTLLSSLVPLFATLATVLVLMLGLNCSANQMAGVTATYDGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC35</accession>
    <name>A0A0R3XC35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11095</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022946">
        <property type="protein sequence ID" value="VDM36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC35"/>
    <dbReference type="STRING" id="6205.A0A0R3XC35"/>
    <dbReference type="WBParaSite" id="TTAC_0001111201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001111201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001111201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001111201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22441" checksum="9DFF7B02A9F035E3" modified="2016-01-20" version="1">MGTHISRNEKISSDPERQAQYVKMKRDDERRWNAADMNFDNKLSLDEYSAFLHPQDYPRMRNVVIEETLSSVDTDHDGYISIEEYLVDLAKSYGRTFDPKAPLDDWGQKEKEQFLKHRDKNGDKRMDRQEIGEWIMPTDYDPVEAEAKHLIYHADDDKDGKLQEKEVLEHHSLFVGSQALNYGRPLGHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDE6</accession>
    <name>A0A0R3XDE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11556</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024966">
        <property type="protein sequence ID" value="VDM36984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XDE6"/>
    <dbReference type="WBParaSite" id="TTAC_0001157301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001157301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001157301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001157301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21426" checksum="B6CEDB0FFDF402DF" modified="2016-01-20" version="1">MCVCIGANGEKGWLWRYVRSSMTYPLLLPPLCDPSDGHYLIDGVFVNVLPGSPLSPLISTLXXXXRRLRQCPSSLHAAVSQSEPISFFPSPLIRLISAVTSTYPSMHPQMRSGSLWRYVRASMSLSGYMPPLCDPVDGSYLLDGGYVNNVPGELLLFLPYSFHSFVSFPCRDSCMLLAFCSFSATFSCTNLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDF6</accession>
    <name>A0A0R3XDF6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025074">
        <property type="protein sequence ID" value="VDM37048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDF6"/>
    <dbReference type="STRING" id="6205.A0A0R3XDF6"/>
    <dbReference type="WBParaSite" id="TTAC_0001158301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001158301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001158301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001158301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13410" checksum="D93D970C5A29DE45" modified="2016-01-20" version="1">MLKTGESQRIWASLLEVATTWLCLLVHWPFHTAWLSLFLEEHYVCTQQRVPRGSGEVASGGTPSLEVDEDDATASTTSQPVLPDDTLSMLYSRVLKRYCFLLSVVSPQTSPNLLSRMPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD73</accession>
    <name>A0A158RD73_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ras GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS12</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD73"/>
    <dbReference type="STRING" id="6205.A0A158RD73"/>
    <dbReference type="WBParaSite" id="TTAC_0000001101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000001101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000001101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20810">
        <property type="entry name" value="C1_VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="219"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="377"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="480"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000001101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="61075" checksum="801361DF11297548" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDW0</accession>
    <name>A0A158RDW0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6169</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDW0"/>
    <dbReference type="STRING" id="6205.A0A158RDW0"/>
    <dbReference type="WBParaSite" id="TTAC_0000618401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000618401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000618401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013584at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000618401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1196" mass="128386" checksum="86113231F230D135" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE30</accession>
    <name>A0A158RE30_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6526</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE30"/>
    <dbReference type="STRING" id="6205.A0A158RE30"/>
    <dbReference type="WBParaSite" id="TTAC_0000654101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000654101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000654101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000654101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57582" checksum="8049E9780440D321" modified="2016-06-08" version="1">MFLNTLTPKFYVALTGTSSFLSGLILIFEWWYFKKYGTSFIEQISLTHIYPLLGGSDEENDCDSVDSGGVHNGIQDCKVSRNPYSLFRGAEYQRAAKEFGQDPLTYYDMNLSAQDHQTFFICEADAGKPEYELMQMAWRERNPEERVKKAREALAKNPDCVTAMILLAEEEFSSVVEVEKTFKQAYKITESSLRKSQQSHSHNPTQDAIYLRDIHAFIFIRRRLAMCARKLGKLKEAIKIMRELIREYPNLNLFNIHENLIECYLEAQQYADAQAFLTKYDDIHYPKSATICYTAALLKARQVAEKFSPDIASKRGLSNAELSAVEAIHRAVEFNPHVPRYLLEMKPLILPTEHILKRGDSEAIAYSFFHLAHWKAVEGALNLLHCTWEGTFRLIPYPLEKGNLFYPYPHSTESTDRELLPSFHTVSVYPKKDVPFFIIFTAVLCSLTALLAFLTHVYPDQMGSFSSQDGGEVNRCVGYVRTTCCAADLATALNPRRARRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB4</accession>
    <name>A0A158REB4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6992</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REB4"/>
    <dbReference type="STRING" id="6205.A0A158REB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000700701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000700701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000700701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000700701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="691" mass="77602" checksum="9840F7C7D91641FD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REW5</accession>
    <name>A0A158REW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CLASP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8201</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020462">
        <property type="protein sequence ID" value="VDM32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REW5"/>
    <dbReference type="STRING" id="6205.A0A158REW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000821601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000821601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000821601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="631"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000821601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="903" mass="98844" checksum="C5A3BF6FFA869F63" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF02</accession>
    <name>A0A158RF02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myb_DNA-bind_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8474</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020512">
        <property type="protein sequence ID" value="VDM33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF02"/>
    <dbReference type="STRING" id="6205.A0A158RF02"/>
    <dbReference type="WBParaSite" id="TTAC_0000848901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000848901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000848901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="265"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000848901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49881" checksum="C9C14C453DFA8B31" modified="2016-06-08" version="1">MGIILRKTEEKSSNVTPSHPAPSADLLSPKDNVENVLSSAVPVEPETNRLPEVKEVGLPEIPSVSPTCEIPLPSKETFPKNSSQCFAPSSTASVDIDEEHCNSSCKSSSSLSSIKLFVVKQTPRRHHVYGDTPPPADRPLDRSTVTLRSLLNWIPANKPPPRVRDIHPNPKPLKHDSPRVTSPTSKSVDKKSEDTTVPAPGEPHIDPLAPQLRLDADGNIVLDEQSLHISHPKTTVMEDLRHVAEEAGLYGTTYNSFRRRPIQHRGRKWTEKDTTRFYRALSTIGTDFYSMTKIFPGRTRGQLLKKFKREERLFPHLVDEALKNKRNYDITVFCKSESDSEEKYEKLTKDAIVEKRKAPKDKSGQRTPKKRSTCDISAIIDEVLARDATKPVDDEDDPIRPRKVLKSASFATSTAAAPCSLMQMIEKTVEETNKAGRTEKSLSSGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E819</accession>
    <name>A0A3P7E819_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000607">
        <property type="protein sequence ID" value="VDM18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E819"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="105381" checksum="8390CB0E2AFA374F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E874</accession>
    <name>A0A3P7E874_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000658">
        <property type="protein sequence ID" value="VDM18721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E874"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21650" checksum="1A852C9B176A2FD6" modified="2019-02-13" version="1" fragment="single">MITVIHGSPIFTLVLGVVVLATAFIGCFGASYLNGCLIKLYAILMMILVIGELIWGTLHIALKDQTLKLIEHYFNTSIAEIESGNADPQLLNSIKRIQNSVGIYISWIAVEHTIRRIGEILMKSAVELEKFVSGFLNRLRLYHPEYMCFRALVLYYPFPLLQGCVQVAEKVLVDNRIPLGISIIVLSLIEMGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EA62</accession>
    <name>A0A3P7EA62_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000969">
        <property type="protein sequence ID" value="VDM19670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EA62"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="320"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM19670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="451" mass="49433" checksum="9C50A5C9E2C2A65C" modified="2019-02-13" version="1">MKLAGAHVLIVGCGGLGCPAAVYLAAGGVINITLVDNDIVEVTNLHRQVMHSEDKVGYPKVESLAQRLRSVNSTVRIVTKNVRLTSQNACDIILGHDIVLDCTDNIATRYLLNDACAACGPIPLVSGSALRFEGQMTVYLTHRPPEHDSSECETKRLRLIDKEKVPCFRCINPSPPPAVQACSDAGVLGVGNFAIVPGIIGTLQAVEVIKLLSGIGGKSHYLFSTAFKLAPFNDVPCLSMAGRLLVFDLERNNIRTVKLRQARPDCKTCNSINRITPEDVKKTDYVDFCDAFSQDMPRSGNAQKSETRISVQELKEIRDSKKPHILIDIRPAVETEICRLTNCLYIPLNELYKESNLTLIRDRIRAAHEVSPNTPFPVILLCRRGNKSHAACEQFAEALERILPRSASSGDLTSFTNGDAKSVITTKVLVRDVAGGLQAWSEQIDNDFPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EJT4</accession>
    <name>A0A3P7EJT4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA ATPase AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002879">
        <property type="protein sequence ID" value="VDM23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EJT4"/>
    <dbReference type="OrthoDB" id="10473398at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18809" checksum="BFE8BE4213BA888D" modified="2019-02-13" version="1">MRRAGRFDVTIHVPPPDAEARRAILQLELSKRSTSKRALEPHWLEVFAKEKLEGYTGAEVVAVVQMAAELTRESQEAEIDRQHLLSACERVPPCTLEQCQVHLQHGVPPSPLSLLPSPPPSPADSLWPSPRQYFVISSVLIVLFALVWQLIMHFDVDTFHWLHLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EMZ2</accession>
    <name>A0A3P7EMZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000228">
        <property type="protein sequence ID" value="VDM17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EMZ2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="50" mass="5774" checksum="59CD0A3D47C12E78" modified="2019-02-13" version="1">MQLEEVLAFAKEGRLQRLQGVPSLPLLRRARSFCFTQRTLPALKLDQFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERR4</accession>
    <name>A0A3P7ERR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002414">
        <property type="protein sequence ID" value="VDM22596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERR4"/>
    <dbReference type="OrthoDB" id="2123794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="382" mass="42130" checksum="A960BAD652B06A6F" modified="2019-02-13" version="1">MRQQRDLEAKCATLASTVRGLQMDLQEKQRMLEAHAQRGRSRSTVRGTVDSTTVLVQLPPQPTPQAHLTKAGAKPKAQVKTTNYVNDSAPRCDTLKNVTKTSIRPATTVLNVEPHKPSEVFHRPQTVETASDLSRSSCLEKRQGYTQAVLKAKENLARLIAEAKSKEEEEGEHNTLKENESKATSLLTVLSTQAYDDWPEFEVAEPLKMQPLPRPVKVQKDIKKTDAVAARGDSMELSETLQRPPVSMASEKTATVISETAAKEEQRELQAKSVDEKEFSFTHTTVSSNAAINGNSAQFESKSQQRSPKEKRVAHSKESRLQHHPYLTAVDAVKDVDSNNTNSAGTTDKMCGTRLASKLFDAQAKSPPPNTSHSSLKQKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EUI4</accession>
    <name>A0A3P7EUI4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001084">
        <property type="protein sequence ID" value="VDM20057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EUI4"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018120909" description="HEAT repeat-containing protein 1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="23578" checksum="D0716344F3C619E1" modified="2019-02-13" version="1">MLVKDTNLINLFVCCLCLLAGERKSKEVRKLVSSLELPHLLECFSSDMAGLDAAAGSCTRSVLAATAAWLRAESQLSACLDTAGTDSVLALPQALIKPLSVATLGLTEIDLVPCVAAFLSAVGGDEALLRPFGACLCNLITRSSDYRMRLAGLRLLKQTFDTLMEAGGKEACVGGSGDLGLAACLVPDTLVALSEALEDDRNEVEAAANSLFADLEAVGVTAQNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EW62</accession>
    <name>A0A3P7EW62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008795">
        <property type="protein sequence ID" value="VDM27551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EW62"/>
    <dbReference type="OrthoDB" id="5847120at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="127" mass="13916" checksum="C6A097A91CEC75C3" modified="2019-02-13" version="1">MMRLVRRQREAYTARVAAGRPSIRRGLNSTGCGATIATSATNSSALATPIATAALSKNERLYRSLIRKYIGKAARQRANIRRDKILMARKAARDCAKAVRQRQAQKTSKDFACKFSSSSHMSSPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F2W2</accession>
    <name>A0A3P7F2W2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002929">
        <property type="protein sequence ID" value="VDM23224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F2W2"/>
    <dbReference type="OrthoDB" id="19830at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="204" mass="22882" checksum="C7970F8A5ABBD51B" modified="2019-02-13" version="1">MLDSFIKKGDYSSGLSVMWELCLQSHFEKEPPTPYTTALWLHTIGELLKSGVFFERSEKIVEVDTEDDVDVDYQSVAYLRNPSYDGWFDIERPRLQLGHCIISLSTAIEGESSPLPQNNLAVDLKSITPSLRLLGFALLEDAKQLLALASMTPLVVYGDVLTAVERLIESSDRRPDNSEAKRGEPVLLTESEVASALENFRVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FG80</accession>
    <name>A0A3P7FG80_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020343">
        <property type="protein sequence ID" value="VDM31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FG80"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="832"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1105"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1109"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1198" mass="129877" checksum="8CE86097701DA52F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GGU8</accession>
    <name>A0A3P7GGU8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001746">
        <property type="protein sequence ID" value="VDM21632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GGU8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="106" mass="12043" checksum="C9152606DD94E87D" modified="2019-02-13" version="1">MLPFSLRVQVSLRRWQDRCGTTYATWYCVIFTSYNPGTMTAFGVVKANVVSRKTVVAMAVSSHTFLLLNSKCFSVKVLSKWVSWIDVVIRLRQGGIQQIGSRHQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GK35</accession>
    <name>A0A3P7GK35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002776">
        <property type="protein sequence ID" value="VDM23028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GK35"/>
    <dbReference type="OrthoDB" id="6281909at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="401" mass="46626" checksum="051DE491366BBC65" modified="2019-02-13" version="1">MHRGLTKDLEAVAKKYKASRERVDAELESDAKALREANAQSEKAFLEQFKQKLDRSVSSRTLRKAVFRDVRDTFSSGSAVLRTPPDIPKSVEELYIEAANFLHQQEATSSSQMAHLKEVHQKKLGHLELQLFSEQYELNMNFAKMQGRMEQRHMHMRHQLARSQLKDFALADRQLLAKRLASQLVELREAAEADKTQLHESQMLEKKIFLKNERAARKKRMSMYQRKLREDGPPDGMSVKEALAKACHSMTSYYSTSPPQLTAVSFDALLRLDKHHQMQTQALDREILSYFVELDEQQWEKKIMLANQETNRLKELDDEHKQEMKAHAERLQRKIMQLREKYEKEVTDRADVTSLKRHSDTLPPPGPGNRSSHHLFGRHPGITSSFESLLITECIRRNEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H1D3</accession>
    <name>A0A3P7H1D3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01009687">
        <property type="protein sequence ID" value="VDM27952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H1D3"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM27952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="230" mass="26139" checksum="44FB86C3AAC9FE96" modified="2019-02-13" version="1">MLVEVFSSSNSSISFPRPLLAENPDIVIGTPLKISEQLLRKHLFLDALEHLVVDEADLIFVFGYEKQMQAIQPFLPKKSLQIILMSATLDETTTSLRTFFKLNEWIRIELPDENILPSESQLSQYIISADEASKYAILISMIQLKLIRGRTIIFTNSIDRCYKLKLFLEEFGVKSVVLNSELPVASRCHTVHQFNRGLYDYLLATDESDSGGVTKPLKRNKLCVAVLIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HA07</accession>
    <name>A0A3P7HA07_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase family member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS6921</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020332">
        <property type="protein sequence ID" value="VDM31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HA07"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="208"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="324"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="13">
        <location>
            <begin position="563"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM31205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76458" checksum="B97F7739F017459C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHQ0</accession>
    <name>A0A0R3WHQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS83</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000006">
        <property type="protein sequence ID" value="VDM15808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000008201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000008201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000008201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274593at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000008201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47815" checksum="C343CCF8E0B8361A" modified="2016-01-20" version="1">MVDNEGWMEKPNSEPLTRCNQYTSRAVNMFGNNSNQEEALDALLEDFSVDESSQTFLDLFRLNLVGVERIIFITLCSCMASVGLSANCCIILANVLHRLRYSRENDFYTGRARSLSRISVVGANPFKVNITPQNRFSYFSALSGQAKFRYSHVIFAIAIFSLISCAAFVPLVVLNVCGGTSSADADNWIVLICLAWSVFQILFMTVFFFVNTTIQFLSLVFPLTFKLQRNPLWGTFLLIVVVCGVHASLTVVVIFKQLFQTLYEIGAGKKNTKLENSITQIQLVLTLPLGVFVVTWIATIIMYAVIVKHIHVAIITVSRISIQPDEHRSSIGSGQSTHSSLWQTVVRKNFHKCLILGAGTLTFYIMETPTFLVVYNLLPPSSWVLLAHLSVHAITPLLHIMLSKSFRSALGRMLRPRRVDSSIAVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI18</accession>
    <name>A0A0R3WI18_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS213</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI18"/>
    <dbReference type="STRING" id="6205.A0A0R3WI18"/>
    <dbReference type="WBParaSite" id="TTAC_0000021201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000021201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000021201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000021201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37295" checksum="78D2A4D606C300A7" modified="2016-01-20" version="1">MLNRKHGLENDRFASKFAEFSGLVGAFRAYASPAIVIIGVLGNALIMYLFWREKPRTRFSVFAISLALAHTSSLIINTALDDFLGRGLHYATGGAFSLKLDATSEISCKMLEYLPNTMYFIASYLVVVFSIDRVLSVYYPIRFHACYYRREAILACLMVAILGASGNIPTLLVQTLKTEKEGNIACRMNRNRAMLADFAIVFTTVVTFFLPVIMVLVLNLIIIQQLRRAHQWRTTMSNGGRGAQEMGRITGHLAMSTCFLLLYLPLGIVVLMRLHVTVSLDEENTPRAIRIINLSKFLSSLKDISYAVNFLIYTVFLPKFRARLISLCSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI43</accession>
    <name>A0A0R3WI43_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS244</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000016">
        <property type="protein sequence ID" value="VDM16139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI43"/>
    <dbReference type="STRING" id="6205.A0A0R3WI43"/>
    <dbReference type="WBParaSite" id="TTAC_0000024301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000024301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000024301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159822at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000024301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26816" checksum="5193FA1DF2352E10" modified="2016-01-20" version="1">MHNPAPTRIRLPAFWPDQVQLWFAACEAQFAAYGIHNQHARYSCVLALLKPEDCSLLSDLILNPDLTLPYDRLKAALIQRSLTAQWRSARKETPSAIVHRIRHALYEKAVDADETALKEMIIPFLPPAVRSVLEPVKEAASLDQLAQMADRVMAMKMEGEALEAAFGEMVSQQQQQVWRQRPGRFRRRSTSRRPRTPSQRQFICEYHMRFGEQAKHCHPPCDYNLREQKIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIH3</accession>
    <name>A0A0R3WIH3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS399</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000033">
        <property type="protein sequence ID" value="VDM16386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIH3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000039801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000039801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000039801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09331">
        <property type="entry name" value="LIM1_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09332">
        <property type="entry name" value="LIM2_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09335">
        <property type="entry name" value="LIM5_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000011">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000017">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047944">
        <property type="entry name" value="LIMS1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047946">
        <property type="entry name" value="PINCH-1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038003">
        <property type="entry name" value="PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="227"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000039801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41297" checksum="F1294086721750E8" modified="2016-06-08" version="2">MGPPGDSQVISTDFQRDIPGVGNGAYDNYSPSDEFSRLDVGDDFCLHCHEGFKVNEKVVQARNEKYHVDCFVCAQCFQPFPDGVYYDFDGRKYCEHDFHVLFAPCCGKCGYFIVGRVIKAMNSSWHPECFRCQICDKCLADDGFVKHAGRALCHECNAREKANSSDRILCFKCHSYVDESQQLKYQSEVYHAYHFTCSSCGSELSSDAREKDGDLYCLRCFDKMGIPICGACRRPIEERVVHALGKTWHVEHFVCARCEKPFLGSRHYEKKGLAYCELHYQQLFGMLCYSCNQVIPGETVFALNKAWCVDHFGCIACDRRISPKTKFYEFDLRPVCKSCYEMFPIELRKRIAKMHKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIT8</accession>
    <name>A0A0R3WIT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS537</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000051">
        <property type="protein sequence ID" value="VDM16598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIT8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIT8"/>
    <dbReference type="WBParaSite" id="TTAC_0000053601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000053601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000053601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000053601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22743" checksum="88E71C8D0D4F3F59" modified="2016-01-20" version="1">MRDISSEEMKNFLHSTLGITNLHSLDGICRASAKMNIDSTPTCKRYISPSAFVRTLSIMLRGTVDDRAEMAFYAIDFDSDGLLRKAVEIRRLLQDSFDASIAAQNAEIDPEEPIRDVANFLCDKLNCTITSHVSLQNFREKCQQQPWIVECLLPCIPEEKINYIFQSIFTTSVNIPSLEAAAQPTGPTIKCASMRRSAFSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ50</accession>
    <name>A0A0R3WJ50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP synthase-coupling factor 6, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS679</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ATPase subunit F6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000077">
        <property type="protein sequence ID" value="VDM16824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ50"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ50"/>
    <dbReference type="WBParaSite" id="TTAC_0000067801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000067801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000067801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8902296at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.110">
        <property type="entry name" value="Mitochondrial ATP synthase-coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008387">
        <property type="entry name" value="ATP_synth_f6_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036204">
        <property type="entry name" value="ATP_synth_f6_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12441">
        <property type="entry name" value="ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12441:SF10">
        <property type="entry name" value="ATP SYNTHASE-COUPLING FACTOR 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05511">
        <property type="entry name" value="ATP-synt_F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111357">
        <property type="entry name" value="Mitochondrial ATP synthase coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000067801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14864" checksum="138BCCDD5F1B0671" modified="2016-01-20" version="1">MILVPYSRLLTCRTLIFTRHASLATQQVADPIQRAFVEKLREYQGKSKTAEMGLVGASQAQIKSLKDSLEKLDNVFNAKGVDMTQFPVLQYKEPELVNPGSSIVVEYPPAEPLQDVEKIERMDGILTKGPIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ6</accession>
    <name>A0A0R3WJJ6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS846</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000111">
        <property type="protein sequence ID" value="VDM17071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJJ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WJJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000084501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM17071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51682" checksum="79EBB379AEC009DF" modified="2016-01-20" version="1">MSTEKFPFDAYALELCVIMFLSLAAFFITKSLLSSFGQVFFRAGLCGADMSKPGKPVLYAERFAYFFMFRPEAQGVVAATVYINCMFLFIPLPFRAHILQSLSWYNPKSTLFVFVQPSLSDSDIIAEQAVLFKTRLIPFLAALLSICCMVFLGFADDVLSLRWRHKLILPTLSSLPLLMVHLANLGTTRIAVPLVLQGLLGTSVDIGFLYYIYMGMLAVFCTNAINIYAGINGLEAGQSIVIALSVICFNIVELNGLEWKAHLFSLYFLLPFAGVTMALLQKNWYPAQLFVGDTFCYFAGMTFAVVCILGHFSKTLMLFFIPQVFNFILSLPQLFQLIPCPRHRLPRFCERNGLLYPSTVSLHVSSLSSVGRLCLQTLLYLGLTHRNTPDPEKCVDLDSKEETDSGEVVIIDNLTLINLFLRLTGPVSEARTAASLLVLQVLCSCLAFVVRYPMAWSLYGQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKN6</accession>
    <name>A0A0R3WKN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tubulin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1281</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000246">
        <property type="protein sequence ID" value="VDM17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKN6"/>
    <dbReference type="STRING" id="6205.A0A0R3WKN6"/>
    <dbReference type="WBParaSite" id="TTAC_0000128001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000128001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000128001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6234632at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="48"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="250"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000128001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="616" mass="68990" checksum="721C7712AEA8A444" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKW5</accession>
    <name>A0A0R3WKW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1373</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000283">
        <property type="protein sequence ID" value="VDM17886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000138601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000138601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000138601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000138601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="494" mass="53147" checksum="011CEEA3914FD957" modified="2016-01-20" version="1">MHLQENTTGENMGTSNGQEDFRSEVSAVDLTATQPASDHYESGSQSSGKDTVDATIPSAWLSKMKDESVEDGSGNLHSPKALVLVANPSYPQCSSAPTPTVNSASSCTQSPKNSLVNPIFSSRKDKRRIGSVMPLPNQPFSRLSEVEYSPKRLPDLSPSAGCPSKNWKITHSDRLNALIDECERIVDGRKVFKCKFCGKMYDIKSSMRYHMKIIHLQLHLRTSEMQCRICGKQFTCISAVNRHQLKCSANSTSNFTSTNPIQSSCGSSFLGKPRQSSLPTFANQSPSAFMNLNNTPGIRWSGVTSSGRHSNQPITSQNPFTFSSTTDTPAYISSTVTTPYPTQSVRSGFDLDGPRFTGGPEISPHQLGGSSLVHSVHNLVEGIPPLSFNEVFLASLGRSNGSNSGERKGPIFDDLPPPGFMGAAAVHNFLASSQSKRMRKSENPSFVESRLSENLYERLFPSQSETATAAVTAAAATAAAASGTAIDLSLNASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL88</accession>
    <name>A0A0R3WL88_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1513</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000352">
        <property type="protein sequence ID" value="VDM18131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL88"/>
    <dbReference type="STRING" id="6205.A0A0R3WL88"/>
    <dbReference type="WBParaSite" id="TTAC_0000152601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000152601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000152601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287635at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000152601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="41498" checksum="29E86648944C5A7D" modified="2016-01-20" version="1">MVNNVYFSLLPSEVCRLILGYLSDLGCVQTFNTFFQECSYLAELRNESQTGNKMTYRVGGFTLAEILKDYFTIANIANEKRDSIIKKWNSASLPACHPGEMAPLLVCLLSDTLEVRTSPSSSQDRSCITAPAKKSTLTPVVSVPSAGSNQRITIINPGASVAPTQNRVKIIPSAKALPSTPKVILKVVRTQPIAASVQSSSTSSSSRRKIHSKPAHVTEIESTPTASSRSPLNIQRVFCNLAENAKTVADRINSDLSSGATCESSLSHLDFPIPADIEQSSSGLLEQDMQDIISRLMDDVDSLGAKSPMKTGANAVAVATPSSSPSSSVVTSVVPPGRTDITAGVIPRGRVPVKPTSNPSFDSPPDESLARTWAKSRRVPCKFSSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLG9</accession>
    <name>A0A0R3WLG9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1594</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000395">
        <property type="protein sequence ID" value="VDM18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WLG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000160701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000160701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000160701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000160701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40680" checksum="86A2BB788FDBF130" modified="2016-01-20" version="1">MLVRQTILACQKTSFFVARATVAGANSKGYHGTGACSHQTSPKILITGGLGQLGMPLARVFRSKYGQDSVIVTDIKKPDPAVKDLGRFEFADIMDADGLRELIVENRVDWLVHFSALLSAVGEQNTPLAMKVNIGGLHNIFNVAREFNLRLFIPSTIGAFGPNSPRNPTPDDCIQQPNTIYGVSKVHAELLGMYLNHRYGLDFRSLRLPGVISADVEPGGGTTDYAIHIFKYAMRGEPYPCFLSQNTRLPMIWIDDVIRAMAEVMECPREKLKRCVYNLAGISFTPKEINEAMLRGMHRHGLLEQLKTYELKYDVDFRQKIADSWPEVLDDSNARTDWGWRHEVDIDGMVDKMFEYLKAHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLN7</accession>
    <name>A0A0R3WLN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1662</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000434">
        <property type="protein sequence ID" value="VDM18359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLN7"/>
    <dbReference type="WBParaSite" id="TTAC_0000167501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000167501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000167501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5964980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000167501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9740" checksum="15F2E874D7E69DC7" modified="2016-01-20" version="1">MVDFDKRGMYADYDPMTHMATHYRVVSLGSHVMAAKRLPIFRLRKYVRERIVCDTLRVIMEIEMAFIKSANYDRTEFIFKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMN9</accession>
    <name>A0A0R3WMN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2014</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000684">
        <property type="protein sequence ID" value="VDM18754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMN9"/>
    <dbReference type="STRING" id="6205.A0A0R3WMN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000202701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000202701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000202701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="4">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000202701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="712" mass="75492" checksum="2116257C20B23F16" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMX4</accession>
    <name>A0A0R3WMX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PUL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000755">
        <property type="protein sequence ID" value="VDM18908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMX4"/>
    <dbReference type="STRING" id="6205.A0A0R3WMX4"/>
    <dbReference type="WBParaSite" id="TTAC_0000211201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000211201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000211201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000211201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31872" checksum="DBA79C5A75C33D07" modified="2016-01-20" version="1">MQQYSLWMSDYYRIRRLSELAFPLLDLLRCLVRWHSASDAIFQPSTWSAILHASGLDLLKMDVAASPTLSPAELNCILFLFRLLANAVASDTCRVKPGFSVPPSLPIILEEARRFVKLVDSPVLNIFDRKKNHLVALATLMHNLTVVAYQTISTHNAIVTAIPTLRGLPGLCVRMTTNLLLFTAPTGTESVTHYPPEVPLRLLIALATAVISSAPGPTEGTPLSTESEAALRLRRACLIGSAATASGSSEADADVLMGWERIRDVIHFWTQCKIAQASIRGCASELLRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNL1</accession>
    <name>A0A0R3WNL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2336</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000974">
        <property type="protein sequence ID" value="VDM19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000234901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000234901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000234901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000234901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21716" checksum="5F4612E4C44F6DA8" modified="2016-01-20" version="1">MPPSALHLPLVHPAAAFASPLTNAAEQADISGSIHKTHDDRQFVTLVVHSEKPQTGLCDAPQFARRMARFQSMEDCNTCDSIMSASPRLVVHLDDARPLASSSSSDFGCVDYGEDQLPKETSFGLRGLKMQHCEAKHEMHDVELSRTDSKVGVCRISRRGHTLQDAELHGRLPGGGPIVEANPLWQPFHRRTDADSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN7</accession>
    <name>A0A0R3WPN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rap guanine nucleotide exchange factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2712</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001418">
        <property type="protein sequence ID" value="VDM20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN7"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN7"/>
    <dbReference type="WBParaSite" id="TTAC_0000272701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="319"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="63069" checksum="A50BEE71BA4528C2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPT4</accession>
    <name>A0A0R3WPT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2759</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001480">
        <property type="protein sequence ID" value="VDM21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000277401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000277401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000277401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950721at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF9">
        <property type="entry name" value="GLUCOSE TRANSPORTER 4 ENHANCER FACTOR, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000277401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16650" checksum="1F926871BEE3F62B" modified="2016-01-20" version="1">MTEGEARQLSETMLAGSSLASSHSAGVGATTTTPERSSHLPTSLASTMRSFTPSASTPSAQVFTFACTTSAAATVTTVDVTAPSTTYHAGPSSSVSSSAPVSASTSDFQPGFRRSEAAKCRRVYGAVNKSRWCKQCRWKKACTRFQGPSPHQKDPPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPY7</accession>
    <name>A0A0R3WPY7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001538">
        <property type="protein sequence ID" value="VDM21223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPY7"/>
    <dbReference type="WBParaSite" id="TTAC_0000282701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000282701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000282701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000282701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22887" checksum="DF2F7AC79FCFC860" modified="2016-01-20" version="1">MDKPTFEAMYNELTQRLVLSISNPEGVIGDFGGYEILTKSGHLGWQDRWDSLAVLATEKRYFTTTLEKQSAAYVFTVRGRVPPNCFSEMADPVEFRRLNKELSAPQNVRIKALDSHTLYMTWTPPAKNYGIITGYVILWTHDLSTLHYTQVISNHVYRFSSLKAQQNVSAAVYAESRPRSHMKFKYLGSFSDFVTATTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ38</accession>
    <name>A0A0R3WQ38_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2863</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001604">
        <property type="protein sequence ID" value="VDM21349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ38"/>
    <dbReference type="WBParaSite" id="TTAC_0000287801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000287801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000287801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000287801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17117" checksum="A0A5575ABFE4A559" modified="2016-01-20" version="1">MPECKIPIYTASIHMHVSSFNSFFFFSFFFFFLLLLLPLSPFYCVQAMRDATKCVVWCVYHPFHLGFIIITIIITTTTSIAADVTAATAAVETATIFIGLPVPRGTCFDPEFGKLTTSLDATRWWLTHPGVGQRECSTFIPLEEECGTGIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQM7</accession>
    <name>A0A0R3WQM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3052</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001853">
        <property type="protein sequence ID" value="VDM21834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000306701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000306701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000306701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="4">
        <location>
            <begin position="68"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM21834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000306701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47113" checksum="D8DA65F049011BF6" modified="2016-01-20" version="1">MAELSNLSQGGSFVFLGRIRSRTADFDKLRQAQVDRTALETNLLLIRLEKLSNIPDNLDNSQRHVLEQSIVPWIMAKVSLCPRCGASFGLGWSKYSTSGDSTATATSHSFLVTPPTSLSRRAREGLHFASRFVSTLIDNDPVYRRMHHCRLCGHIICADCSFFLSKEEISHVIKACNWAKSESLAINAVSSENIPSLGGEILNCKPPFLSRSTSLTSLDSSVPKRTEEVPKLRICEVCKLVLEGKIQQIEEGNATPLGLEEFQALKQAMAKVTEKMPLFSSMANSLSLGEEKYILDIAKSLRLELLQNLQKVDEIGKVIASLDVSTSRSAATQARLNRTIGQFARRFVRNNLSSLRILPSEKEHRQLAQKRTTDLESKRQESAALVSKKADTVSRKPEKLLPPPKRGQVVLFARDDHKMIMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQY9</accession>
    <name>A0A0R3WQY9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3164</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002009">
        <property type="protein sequence ID" value="VDM22081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQY9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000317901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000317901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000317901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000317901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20895" checksum="1EC74BF2B1E05FFB" modified="2016-01-20" version="1">MPTANEGFHWPWQYDFPPFFTLQPNEETRRKQMDAWCQLVLSYFQCKKQFSVDVSSLMASQCELFNNSKINRKANPLLIQAIFDELHRRGNLEWNDRSHKTASIQWRKASSWAADIEKWVRATGRGNTVCTIYEITDGDDTEGEPFHGLDRAVITEALRYLEKHGKAEVMEGGEGVKFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR00</accession>
    <name>A0A0R3WR00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002023">
        <property type="protein sequence ID" value="VDM22108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR00"/>
    <dbReference type="WBParaSite" id="TTAC_0000319001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000319001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000319001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000319001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30788" checksum="6B14C91354685C5A" modified="2016-01-20" version="1">MTLIFPPDSYRINITLVPRDEDGVYVLGSTNILRCSININGSLMDLDPHIPTCRLRVSNESALNVTDGAIRLTPDQHPGPITFDIVASLFEMDVMVKSTTVWFVEEARNYPNFVWGWYDPLKRVHRKYVVVDTFEEGAHHLSCSSPRSNVPPLNITFYVLRYNATRLIFSPPPLTRYKRSDRLPKCVWTVPWMNDEPGLTPVLTRTGTNRNGIFRGLSRCVFIAPGLHQTISHSFRVIGEVQLSPPCIKNILCVLAFAKPNSMCTTMNHSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB5</accession>
    <name>A0A0R3WRB5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3290</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002193">
        <property type="protein sequence ID" value="VDM22327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000330501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8883" checksum="880A34B368EF7CBE" modified="2016-01-20" version="1">MPYGAQKSAIVQARLSQFQENETNVVHFREIPSHVLQKVCSYFAYKVRYSNSSSEIPEFPIAPEISLELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRG0</accession>
    <name>A0A0R3WRG0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiolase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3335</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002265">
        <property type="protein sequence ID" value="VDM22413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRG0"/>
    <dbReference type="STRING" id="6205.A0A0R3WRG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000335001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000335001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000335001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000335001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="24345" checksum="BAC6E6AE9F8ACC1E" modified="2016-01-20" version="1">MEALAKLPPAFANGLPRSQEATVTAGNASTLADGAAALLLCRADTAKALGLKCSLGRIVAWHQSGCEPQVMGLGPIDSVKGLMEKLSWSVDDVDLFEVNEAFAAQSLAVCRQLIFLFAASLVVAYFYSIIQVLNELGLPKERTNVNGGAIALGHPIGCSGARIIVTLVHSLHRLAHNYVANIKTNSANCRRVGQDGKLRGIAALCVGGGMGMAIAVEILPHLTVSDCPLIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRK7</accession>
    <name>A0A0R3WRK7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3382</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002342">
        <property type="protein sequence ID" value="VDM22510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRK7"/>
    <dbReference type="STRING" id="6205.A0A0R3WRK7"/>
    <dbReference type="WBParaSite" id="TTAC_0000339701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000339701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000339701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2151624at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="123"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000339701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="37805" checksum="BE851F5761D994C4" modified="2016-01-20" version="1">MYMCKAEASNPFYHLPTPVDQITEVLFTSPTTSAPTASSSVDASAFTTTPTSFRPSLIDSGINTEFLIQVQPIRLIVFSRPRMLPGNPRLVDIKTSTSSAPHNSWTTRGHFNDRPLRRQGSKPPLLPPWAYVNRPVAREGEKMVLECAARGNPPPKLVWFKGGGGSNLPPPEGLASLHDVNFDVGVREALNYLPLVEAMKYLGTRVAEDDQLFPAIVETPTKTNLSGVISLADMEGAHLTSKETDFTGTRLDRFSVVAGLRKDDTGVPMIAVSRLIVDDLGVSDATRYTCLAQLDMAPLGGHGNWTDVGRLVGNPDAENNSLLLLKVCLLLDDAASFLAPRPENNMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRR7</accession>
    <name>A0A0R3WRR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BK_channel_a domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3442</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002439">
        <property type="protein sequence ID" value="VDM22636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRR7"/>
    <dbReference type="STRING" id="6205.A0A0R3WRR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000345701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000345701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000345701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="11">
        <location>
            <begin position="141"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM22636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000345701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58222" checksum="2D77219352E9C918" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRT2</accession>
    <name>A0A0R3WRT2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3456</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002461">
        <property type="protein sequence ID" value="VDM22667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRT2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRT2"/>
    <dbReference type="WBParaSite" id="TTAC_0000347201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000347201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000347201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="241"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000347201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46666" checksum="31A00393F9846BC7" modified="2016-01-20" version="1">MLCPDYLDLFNVGLNRNLHERLIKKKNYSPFVRPVKTHNSAVLLFMNLSLIQILDVDWKDHNFTWDPKEHGNVTSLLLPSEDIWTPDLALYNNAGGSWDLASSSSTLVVVNYDGTVTWRPPIIFKSQCEINVEYFPFDMQNCSMKIGCWTHHGLLIDLRHTSQKARSQPSFDNCRSQIDHAIDLSMFTTDVQWDLIGVSARRNIEFYPCCTEPYLDITFYIILRRKPLFFGVNVICPFFEISPPTSLVVPLIVKYLLFTMVLIIFSTIATVVVLNVRTRSPGIHRISPWIRKVFIHTFPKILLIKQYERIDTYNFQKDFSSPANGWPSSIQVFSSVNSNILAGLSPEQLEESLNKVRKTILYFRQQEEWNKTPTLYTNERVLTASTAHAMDAINVTRLSCETKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WST9</accession>
    <name>A0A0R3WST9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3814</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01003100">
        <property type="protein sequence ID" value="VDM23458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WST9"/>
    <dbReference type="STRING" id="6205.A0A0R3WST9"/>
    <dbReference type="WBParaSite" id="TTAC_0000382901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000382901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000382901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM23458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000382901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29518" checksum="0305AABA2BD12849" modified="2016-01-20" version="1">MKSNVISAFDDDLLHSTVVDASNINVLAKDLSSIHLEGDPEIQWLLRTVGFIDLTTLAGDDTSANVHRLCAKAKRPLSTPILDKLSERYGVSPEEVRTAAVCVYPYQVKTASDYLKRINASYIPIAAVATGFPSGQYSLKSRLEEIRYAIDSGASEIDIVINHLYDEICVMRTTCGSRIHLKTILAVGELGSYANVYAASMACMLAGADFIKTSTGKESTVNATLPISVVMCRAIADFQDTYGIKNFRASFLSSTLSRPPLALRISSLHSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT83</accession>
    <name>A0A0R3WT83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3958</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003367">
        <property type="protein sequence ID" value="VDM23856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT83"/>
    <dbReference type="STRING" id="6205.A0A0R3WT83"/>
    <dbReference type="WBParaSite" id="TTAC_0000397301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000397301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000397301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="7">
        <location>
            <begin position="192"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM23856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000397301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39931" checksum="B45D96121A5E3BE6" modified="2016-01-20" version="1">MVYSYLASDCVKVLRGVCSVLSTAVSIQADEVRIFLELVGARDCIRGVGQLRPVTACDIKRRSYPRKGSSCTNSLDSLIKIRSFSTSIKASSESPPAKKTLSSSRERHVPSTRIGRAVGFGRLGAATEYAKRSIGASDKNEESNIFLNDANLERIVDTLCRMRGAALKLGQMLSIQDSSLVSPKVQKIFERVRQSADFMPTSQMYQVVDAELGTNWREKLASFDAKPFAAASIGQVHLALLPDGRRLAMKVQYPGVGKSIETDVANITMILKRFNFLPRGLFAESAIRTAKRELKWECDYMREASYAEKFARLLINDPVFLVPKVFHDFSTQKVLTMEYFEGLVLDDCISLSQDVRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT90</accession>
    <name>A0A0R3WT90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3967</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003382">
        <property type="protein sequence ID" value="VDM23883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT90"/>
    <dbReference type="STRING" id="6205.A0A0R3WT90"/>
    <dbReference type="WBParaSite" id="TTAC_0000398001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000398001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000398001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000398001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16451" checksum="DC2F2759E4BFE636" modified="2016-01-20" version="1">MYQKMVDVDPNEPTPLEHQQAAITKLRYMQWREELSSSADLGFRIEGIKVGCLSNPLRDSLIDVFITLQITFFAVTFYERNFLFSPFKFWQPLKVLKTAVVLLFVCLPCGCKSSVLALLDRVSLLTLFTSTTFLPLLQAFSNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTI7</accession>
    <name>A0A0R3WTI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plakophilin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4062</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003586">
        <property type="protein sequence ID" value="VDM24086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTI7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTI7"/>
    <dbReference type="WBParaSite" id="TTAC_0000407701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000407701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000407701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10584191at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000407701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26758" checksum="8F386C8E2419F309" modified="2016-01-20" version="1">RSYRLQLHQSVSERSTPTIIEEQEAEDFEEAEYRQLQQEGYNFSQHLADNNGIMSTTATTQDLDQLLEELRRTSLDYSSTATRNLAPHPNGTHSSRLYSGYQRPTFTDSGGGSTAGRYSTRSYSFTGSGGSRPGGRWTNTSSTSTSYQRSQAYSTERGMGEKRGTTTGEGGGFVRHATPAPQLSSSQQQRYQTTFRTTLQHKPPVSPKWFNQINVTIDPEFGTASVCDTYTSSTQRVLSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTY0</accession>
    <name>A0A0R3WTY0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4205</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003911">
        <property type="protein sequence ID" value="VDM24424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTY0"/>
    <dbReference type="WBParaSite" id="TTAC_0000422001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000422001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000422001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512473at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000422001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11411" checksum="B5AA4D9EB69EC590" modified="2016-01-20" version="1">MAEFLEAERLEPRCWAINAIFLAKCEYAGSRYSEAMKWLEVAEQLLLCKGNSDENNQGSGGGDSEVEKGLETSNIKDAVVERPALLAEIETLKPRYRAYLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU93</accession>
    <name>A0A0R3WU93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPPIV_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004138">
        <property type="protein sequence ID" value="VDM24668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU93"/>
    <dbReference type="WBParaSite" id="TTAC_0000433301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000433301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000433301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000433301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11562" checksum="DEEBE8E582F0DA51" modified="2016-01-20" version="1">MHVVIAPQTEDDQELRCVHWPWNFTLREGPLWIYAAAAASEDGVVIGEEDDVGFVWTTQSSSSLDVVQQFQRQAVVGVLVVANRKVVMVAHFLTEHSPCGGWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV19</accession>
    <name>A0A0R3WV19_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein mS40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S18-2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">28S ribosomal protein S18b, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4595</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004850">
        <property type="protein sequence ID" value="VDM25249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV19"/>
    <dbReference type="STRING" id="6205.A0A0R3WV19"/>
    <dbReference type="WBParaSite" id="TTAC_0000460901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000460901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000460901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040054">
        <property type="entry name" value="MRPS18B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13329">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13329:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000460901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32105" checksum="33FDC4B0F201CE91" modified="2016-01-20" version="1">MYIIRAAIAFASVSNYRCCENALTFLYQSFSSASKLVEPTAVAYRAAMKNGVPLEELPMRVNFRGKPYKPVSLEESIQYLSSPEYQELYRGKPVWFYFRRNYKGHFPPKYPRKSCTNVGLLKQFLHPLSSDILEPKVTGLCEVQHKALLLAIEMARDMGTIQMRVPFRLFDYSEYYGDIMQPEELRQLASHVVKASGSGGQLEPLNDIYRKAASSLASLPPSITRLLRQSAVIPHIEEVAAEPPTVEIDRPKIPNRYQMEERYRKLLLSRKRAKSILLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVK8</accession>
    <name>A0A0R3WVK8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4783</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005317">
        <property type="protein sequence ID" value="VDM25634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVK8"/>
    <dbReference type="WBParaSite" id="TTAC_0000479801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000479801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000479801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000479801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14182" checksum="7DC13A0C4415EA7E" modified="2016-01-20" version="1">IWLFDQRSCLYTTTIDTAKVASPCECDASSLTEGVVVMADRTPVLKVLYRLRTPLSPTDSSKTVDPLFDEWSRDFSVGHLQLPLETCTQLATCLTQVTQRLAPQVRSGKGRTEGFTVGLSAEFKLILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWV2</accession>
    <name>A0A0R3WWV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006671">
        <property type="protein sequence ID" value="VDM26522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000524201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000524201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000524201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10603809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000524201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19589" checksum="E1DA77A5D05A803C" modified="2016-01-20" version="1">MFSEVHHLDSLVIQHIGVYTVCPVSSLTSFTEPSESHTQEIIKLSSFLGSSPHQAIASARPDSQSNHQRLYKCITTSSVPTVESQRGKSASSPAVISGDKDVVAPTGEKLHTLCSQFLTSLYQPQRPPEFWEKCVSSLMFFGHEFLSFFLAKRKCLISSCLRIPKRGAKVDLLECCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX47</accession>
    <name>A0A0R3WX47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5322</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007029">
        <property type="protein sequence ID" value="VDM26687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX47"/>
    <dbReference type="STRING" id="6205.A0A0R3WX47"/>
    <dbReference type="WBParaSite" id="TTAC_0000533701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000533701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000533701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406708at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="417"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000533701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="478" mass="50716" checksum="C76BFCDD5BBC126D" modified="2016-01-20" version="1">TGYDGPHCEQPICRPGYCKNGGICRIQGGIPICDCAGTDYDGKYCENPVCRPGYCQNGGRCIVENGRPVCECRGTGYGGSRCDQLLCPPGYCQNGGRCVLENDRPVCDCRGTGYGGSRCDQAICPPGYCQNGGRCVVENGRPVCDCRGTMYGGSRCDQAICIPGYCQNGGRCVVDNGRPVCDCRGTGYGGGRCDQAICPPGYCQNGGRCVIENGRPVCDCLGTEYGGSRCDQPICPPNYCLNGGRCIVQGGQPVCDCTSTRYQGRLCEVPICRPDFCLNGGQCIVQGDRAICDCRGTGYDGTNCETPICRPGYCMNGGSCTIINGRPTCDCSNTGYGGQLCEQPICRPGFCLNGGRCIVQNGQAICDCRDTGFVGQHCEQSICRPDYCMNGGVCSVINGQPTCDCRDTGYSGPLCEQPICPDGFCLNGGRCTVQNGRPVCDCSGTDYRGDRCSHPICPPNFCLNGGVCYVYDGNPRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX64</accession>
    <name>A0A0R3WX64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5342</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007108">
        <property type="protein sequence ID" value="VDM26755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX64"/>
    <dbReference type="WBParaSite" id="TTAC_0000535401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000535401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000535401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000535401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23056" checksum="DCBD747FCB1458A5" modified="2016-01-20" version="1">MRRGRVRIPAIHHSMLHTFLNRTSTSFACAFWAGGERVAPVHTLVTPERPNNEATEQSQVRLMHMLQVVHSRTQHNSILGDYFAMPTEINIACDTWSGVAVAHKYSALLTHASPTPSTICTSPHHASLAHTSSRQTGGAACKGKVSVPHICRADNGQHDEHCACLLGEQIGRTCTQFVCLLEAVGCGWGMVFVCVGRWWVRWRRKLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY13</accession>
    <name>A0A0R3WY13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5637</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008338">
        <property type="protein sequence ID" value="VDM27358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY13"/>
    <dbReference type="STRING" id="6205.A0A0R3WY13"/>
    <dbReference type="WBParaSite" id="TTAC_0000565301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000565301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000565301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229420at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM27358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000565301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26071" checksum="6A923B12CE89F1B3" modified="2016-01-20" version="1">MVEAPSRLKMGQFVLHTRQCRVGNEYILYSGFAFLCLPAFIILLFYLGLSFGVCGDRPHEEASFCNRGVGANLLLSGVVFTFLLSSLLMLVCTGIFLSGGLVQTEVCRYATHRYPAGPAVLDDALEVFVEHQLRQGAEFPSYLLRTNPNISHHLKNVASARPFSVLLTHCANESFVDSLGDEVVGMMVSDTVRYGLVPSNLPLTFLLICLGKFNVPSSLGNLSFMLKGHMINSCSPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYR1</accession>
    <name>A0A0R3WYR1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5889</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009570">
        <property type="protein sequence ID" value="VDM27896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYR1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYR1"/>
    <dbReference type="WBParaSite" id="TTAC_0000590101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000590101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000590101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000590101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19355" checksum="DDB490A537E4744A" modified="2016-01-20" version="1">MHPIFTPSKWTTNASNIEQQEKQEDGDSESAGALANAGRDQMPPELEHFERIPFPDAVEQQFEETLCHLQMKPSTIRSLEEAEALVQSVERRYTQRMVQLMQSYGLNPPKGSSRTGVMETISEEAPKGLNQFHHRSSVANVSFVNEETGEKGSFQRLVWKGMNSFPNATEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYY6</accession>
    <name>A0A0R3WYY6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5961</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009963">
        <property type="protein sequence ID" value="VDM28062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYY6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYY6"/>
    <dbReference type="WBParaSite" id="TTAC_0000597601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000597601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000597601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM28062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000597601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16588" checksum="F19564C65704415C" modified="2016-01-20" version="1">MEAEVSNLPPITLSNSLKNAKEESNQNGGADVPTLPKLDMELVATLGAQRPPESFFNTKPAILPPVQSLLEVLWAAPLPPSLQHSGCHDEDARKCEILANATLDWRNCVARSSTLSMRLCEALRLVLEPTRASRMKGDFRTGKRLNMRKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZB2</accession>
    <name>A0A0R3WZB2_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">LsmAD domain-containing protein</fullName>
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        <name evidence="2" type="ORF">TTAC_LOCUS6104</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Platyhelminthes</taxon>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000611901"/>
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            <begin position="325"/>
            <end position="336"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="VDM30252.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000611901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="670" mass="73935" checksum="8A2EBF7372DE66B9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0R3WZE4_HYDTA</name>
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        <submittedName>
            <fullName evidence="10">TEA domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">TTAC_LOCUS6145</name>
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    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Nucleus</location>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
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    </dbReference>
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    </dbReference>
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            <end position="203"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM30306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000616001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="20061" checksum="DC2C8E04D101FF9E" modified="2016-01-20" version="1">MQPPASSGARLPPPGQSSPSVRATLSSSTSAHVGLPTPFDYPPMHNMVHGFRSPQQPPLKEATSPAAALPSAYDMAAVFISASSSAAAAAAAASAASLRPFGPSAQKRSAAISPLALGSGGGGGGVGSGSPVITGGSECDATTASQSDDAEVDGGAGGGGGGNEADGVWSTEIEQYFQEALELYPPCGRRKIILAEEGKMYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZY4</accession>
    <name>A0A0R3WZY4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fibrillar collagen NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6378</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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    <reference evidence="6 7" key="2">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000639301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1254" mass="120055" checksum="F1D711383E27C0FB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X021</accession>
    <name>A0A0R3X021_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TWiK family of potassium channels protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6427</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020303">
        <property type="protein sequence ID" value="VDM30636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X021"/>
    <dbReference type="STRING" id="6205.A0A0R3X021"/>
    <dbReference type="WBParaSite" id="TTAC_0000644201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000644201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000644201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000644201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35468" checksum="3421E07047A31D8C" modified="2016-06-08" version="2">MKVPRQLLNSTAGLSICLLILTLAGAYIFNKIEGAAEIRTRIQAAKARQRIFVLAQELADEGDDADWSKLVTQVDKYRNKLLQAWKAGNDELGAEIKPPSWSFWGSLYYCITLFTTIGYGNVFPNTTTGRIITICYGLIAIPLCSMVVNRMSKAIARILKAIYLMTLDTSGIPVGLRDAYHRAGSDFDFSLITSFGLLVIYAIFSGVVYCWGIGETATAWSPLDAVYFAFISITSIGLGDIVPTSDVFLNLASLTYILVGLALMNLFFTRLIQLTEAQLERLSGSASDASGALQAGSTNPMQSRYALGGSGRFAAGALANSTTQNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X071</accession>
    <name>A0A0R3X071_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6481</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X071"/>
    <dbReference type="STRING" id="6205.A0A0R3X071"/>
    <dbReference type="WBParaSite" id="TTAC_0000649601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000649601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000649601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9970547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000649601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="51505" checksum="4CCB5E0D08AF3554" modified="2016-01-20" version="1">MFDIQVSELEAVTRKSGEYGEEQETHLVTNGNCERPLTAFTKTDHLCLRSADHLVSISPLQSSATLLSLLLSVTSQKCCCRWRIDASLSSNAKWHRIHGKISSTSPSSNKNARTIISFLGLSSHPCEHIPGRQFRSGSYKCMCRQGFEYPFNDLTWFFDGETMEKEYQLKIEGQPSRYDLLKCRQGHAMTVQTSIGLIFRDLSPTHEGDKWGKERGEVHLQRKCKRSSDRAKINFEDGVIKVWNSRKGRIWISNLEGSSNIRTEVVPYAAGRFSTQPPPKASKANALLTSRHDASVPLRLLSTDTAHSSHTLILAIDKGELTGGVSVGKRLLPLSQHTFVPCLSLLPLTPPPPTPPPPPNYGATSRMGWNVSSRATRVLPPSTSPSSSSPTTVGTHCSSPRLVCVVASTGARLQHIAVHFNFPSSHRATNNHLSSSTSALLLLLLYLPPASLYTGKPEWCAIHSCLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X087</accession>
    <name>A0A0R3X087_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6505</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020306">
        <property type="protein sequence ID" value="VDM30724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X087"/>
    <dbReference type="STRING" id="6205.A0A0R3X087"/>
    <dbReference type="WBParaSite" id="TTAC_0000652001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000652001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000652001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="259"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000652001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120684" checksum="B78D75FD5876B76D" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0D2</accession>
    <name>A0A0R3X0D2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020308">
        <property type="protein sequence ID" value="VDM30793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0D2"/>
    <dbReference type="STRING" id="6205.A0A0R3X0D2"/>
    <dbReference type="WBParaSite" id="TTAC_0000658101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000658101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000658101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272361at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000658101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36237" checksum="25C7AD245FE8463C" modified="2016-01-20" version="1">MSASLWPGRAKLANEPIIATPQMTANHKQATTGTDNREISCSPFYRLTSALKVTATSKKTRCFALLRRKRVMCNIWDDEKVLSLLFQNLRPKDVLTCSMVCKKWRQMLIPEYTQNLQLVINFKRYKEQKVAPIEEQLRLAYQWKVTAISLVCMRDDCVYPFISAYYTTFKEFFPGCPISTPEITHGSFKSVPNLLSRSPTQHSSCADSLESGNLRRLGSAPIEVLMKASRHITQLTVDNCCLSDVALEQILNVMHTVTNLSIVSCNCLSDMALWSCLRPWMTHITVRDCLNFKDDALQAIVQSTPGLQELNLQASILWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0I2</accession>
    <name>A0A0R3X0I2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6627</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0I2"/>
    <dbReference type="WBParaSite" id="TTAC_0000664201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000664201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000664201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133098" evidence="1">
        <location>
            <begin position="17"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="204"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000664201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45274" checksum="9BA6D76B7631B6C1" modified="2016-01-20" version="1">MNKCIFALILITHVASESLTEQERKALLHLHNTKRASVKPTSTNMLEMVYSRRLEKLADDWVVKCIYEHPNEEEYPEYRDLGQNLALSGGLSRNVVNMATEWWEEVKDYTYDTNTCAPGKACGHYTQMVWATSAEVGCAVQRCDNVKPDWPKPVFLMACQYKPALPSMKHTYFHIHNSLPGTMAKLICTLLLVSLVASEAPTEQERKDLLNFHNNKRATVNPSATNMLEMVYSAELEKLAIDWVAKCKFEHPDTSQYPQYSGIGQNLAVSGGSGRNLVAQATGWWNEVNDYNYGSNTCASGKVCGHYTQVVWATSEELGCAVKQCDGMMPGWGPPIYLLACQYKPPGNYMGVKPYTSGTSCSQCPAGTTCVNKLCSKGSSNPSTTTSSSTVTEMGQITLFAAIMIYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0L3</accession>
    <name>A0A0R3X0L3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020314">
        <property type="protein sequence ID" value="VDM30908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0L3"/>
    <dbReference type="WBParaSite" id="TTAC_0000668001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000668001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000668001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246457at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000668001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33169" checksum="DEBC638BB32F3104" modified="2016-06-08" version="3">MLNLFSRSTGRHYSNRFEYSSTNISRRQSVTPSGKTFRRHTFEGTGTPSTPLASPRHTSKAALLPGHPESMDRFTTTLEQLSGLLGWKRKESFQPEFFEAWDRHTTLLSEFREIMGLVEHIEKVYEASKNQQPLARFKQLKACIQRTHLFLQVCAVHSSVAKDVAMYYSRNGGSESDLSFQRSIQRGSVIGSLAKEAEAFRIREQAFDRVDLQQLMSDLGRLKEENEVLTVQSKLLLAELKWLCDRYTDMQGANPISKYFFLKRIIRKVIYGDTLREVSSMKSPVQMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N3</accession>
    <name>A0A0R3X0N3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6692</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0N3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0N3"/>
    <dbReference type="WBParaSite" id="TTAC_0000670701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000670701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000670701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000670701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29424" checksum="43107AA4CDB6140E" modified="2016-01-20" version="1">MGKETYNKTQQLLRRFDPMGIIVRDNFARQDVRLASFEAERGGKLHHDPNNVIIQKNLEISQSGTQTPQFSKPPLSVEPTTAQPAKGPITHRPILPRHRSILDIVFDALVGDGPDRRYALICQQCSGHNGMALAEEFEYIAFRCCYCGFHNPARRTRRTPSGVPQMGPFPSSLDSPSAMATPLALPAVRRPQSTSALNLTSVGRLQLTPISASTENVFAEPLHLHSSQGPRQSQRSLKGCSEPRVSSPSVRGLPEGERKKNLRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1F1</accession>
    <name>A0A0R3X1F1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7011</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1F1"/>
    <dbReference type="WBParaSite" id="TTAC_0000702601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000702601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000702601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246337at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000702601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="792" mass="85794" checksum="689A9B010CFA1035" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1H0</accession>
    <name>A0A0R3X1H0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fimbrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7033</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020340">
        <property type="protein sequence ID" value="VDM31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1H0"/>
    <dbReference type="STRING" id="6205.A0A0R3X1H0"/>
    <dbReference type="WBParaSite" id="TTAC_0000704801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000704801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000704801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="91"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="230"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47246" checksum="ADDDAB45D23B976D" modified="2016-01-20" version="1">MGSRDDRQPAKFSDLLTVFNLFDRDQSGFLHETGILAALKSLGFHKSHGDLRQALENCQINFFQKRINFNEFKRLYQEFCKQEASGSVDPQSTRTTIYQYGSSLSPQGDDTLHSVSEDEQVAFCGWLESKIINCSAPQTIDLRALHRGKRLTTYQVMENITLALNSARAIGCNVVNIGAADIVDGTRHLLLGLLWQIIKIGLLRQINVVAHSELVALLDEDETITEFAKLSPEQILMRWVNYHLKRADCDARMENFTIDVKDCEVYAYLLEQISPPEKKPFLHSSKAILDAVDLVQRAEMVLQNAEKLNCRVFVQPKDIINGSMKLNLAFLANLFNTNPALEPPSPQPSPVVEETREEMSEEEPQPLPSRWECLLAWLKALLPQAPQATRVPRAWFRANYDLLEGKNTKLTGKYLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1L2</accession>
    <name>A0A0R3X1L2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7090</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020344">
        <property type="protein sequence ID" value="VDM31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1L2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1L2"/>
    <dbReference type="WBParaSite" id="TTAC_0000710501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000710501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000710501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051765">
        <property type="term" value="F:inositol tetrakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000710501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36360" checksum="B448FA398D75501C" modified="2016-01-20" version="1">MSRGSEHRQQFLFNNELVAQMLPSGLVSFNRQIGGLNPEKPLKNKFLYDTVNGTVYKVLSARRKGFNEARFYAEVFAPENATDAVLSRLKAFLPAYRGLFHQPSSGNFLVAMADMQWEMEQPNAMDIKLGRQSYGPLAPAEKMVMEQAKYPWRRQLGFFITGFRVDGAFYDRLYGKALSPSTIYEKGICLFLDGKGDENVMYRRSTLAYAFAERLKHLIEWFEAQTLYRFVASSLFLCYDWSSPRSAADLAFPSHRFLRLHLIDFARWFKVSDLNVDSSHDDNCLHGLYKLQSCFHRACSEASSKQTSEADFCVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Z6</accession>
    <name>A0A0R3X1Z6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS7254</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020357">
        <property type="protein sequence ID" value="VDM31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Z6"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Z6"/>
    <dbReference type="WBParaSite" id="TTAC_0000726901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000726901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000726901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="13">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="346"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000726901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="775" mass="84960" checksum="31511D02B7A11490" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X254</accession>
    <name>A0A0R3X254_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS7330</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020363">
        <property type="protein sequence ID" value="VDM31696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X254"/>
    <dbReference type="STRING" id="6205.A0A0R3X254"/>
    <dbReference type="WBParaSite" id="TTAC_0000734501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000734501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000734501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000005">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM31696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000734501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18693" checksum="FEE262FF2340422E" modified="2016-01-20" version="1">MIHFLALFSRQGKVRLQKWFVSYTDKEKKAILREVMALVLARKPKMSSFLEWKDMKLVYRRYASLYFLCAIEPEDNELLTLEIIHRYVEILDKYFGNVCELDIIFHFEKAYFVLDEYLFAGEVEESGYRSIMAAVDAQDMLQEDEVPQSFFEDQSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X277</accession>
    <name>A0A0R3X277_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="13">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS7357</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01020365">
        <property type="protein sequence ID" value="VDM31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X277"/>
    <dbReference type="STRING" id="6205.A0A0R3X277"/>
    <dbReference type="WBParaSite" id="TTAC_0000737201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000737201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000737201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043828">
        <property type="term" value="F:tRNA 2-selenouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.260">
        <property type="entry name" value="NEDD8-activating enzyme E1, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058840">
        <property type="entry name" value="AAA_SelU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037078">
        <property type="entry name" value="NEDD8-ac_enz1_catalyticsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017582">
        <property type="entry name" value="SelU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03167">
        <property type="entry name" value="tRNA_sel_U_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30401">
        <property type="entry name" value="TRNA 2-SELENOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30401:SF0">
        <property type="entry name" value="TRNA 2-SELENOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26341">
        <property type="entry name" value="AAA_SelU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="11" id="KW-0711">Selenium</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="491"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000737201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1223" mass="138049" checksum="CDB3C778D42C080D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2B9</accession>
    <name>A0A0R3X2B9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7413</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020371">
        <property type="protein sequence ID" value="VDM31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2B9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2B9"/>
    <dbReference type="WBParaSite" id="TTAC_0000742801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000742801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000742801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000742801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20236" checksum="093B5B38D60AAEA9" modified="2016-01-20" version="1">MGLERLNIIAAVASNGGIGKENKVPWRIREDMAFFNRITSTSREGKTNAIIIGRRTWLSLPQKSRPLPNRVNVVVSTQLETIPEGAYLVESFGDSLRLVESLVDSGREALEQEVYPVRLYYTHIMKDFDCDTFFPSFDWKRFTHIQLDTVDSGLKHCGDVEFRFAVYERESRALNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2G7</accession>
    <name>A0A0R3X2G7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ homolog subfamily A member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7466</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020375">
        <property type="protein sequence ID" value="VDM31847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2G7"/>
    <dbReference type="STRING" id="6205.A0A0R3X2G7"/>
    <dbReference type="WBParaSite" id="TTAC_0000748101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000748101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000748101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000748101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44653" checksum="86569EF9BA079F88" modified="2016-01-20" version="1">MVKETRYYDILGVSPTATLSEIRKSYKKLALKYHPDKNSNDNGEKFKEISQAFEVLSDPKKRDIYDQGGEQALKEGGGGDFNFHNPFDIFDMFFGGVSRSRGPTRGRDTVHPLAVTLEELYNGSTRKLYVTRSVMCPKCGGVGGRPGCARPCETCNGTGVKVRLRQIAPGVVQQSQTICDECNGSKEFIAPKDRCSNCSGNKVVREKKLLSVEIDKGMMDNQTIRFAGEGDRVPGIEPGDIIFSLDEQPHDRFQRRKMDLIYTMFITVGEALAGFRHVIKTLDDRQLVVETKPGEIIKPNELRCIPNEGMPRYKNPFERGRLIIKFFVNFPDSLSQDKVEALRKILPFSPHDEIDPDAEYCELHPIEEYSSPTNDHQEAYMEEDTDGPQRVHCGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N2</accession>
    <name>A0A0R3X2N2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="5">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7544</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020382">
        <property type="protein sequence ID" value="VDM31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N2"/>
    <dbReference type="WBParaSite" id="TTAC_0000755901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000755901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000755901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000755901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40646" checksum="6472A556ABE906EB" modified="2016-01-20" version="1">MIYMDRVGPGVIGDRNIFQYPKCHCNDGLLHRAFSLFIFRESPSIPGSLELLLQQRSASKLTFPLLWTNSCCSHPCANYDGETEETSALGVRRAARRKAQQELGIDITRCLAVEDIFFLTRLIYSAANEPKDNRWCEREVDYLLVSVLPPNLSLCLHMAPNVDEVAATAWSDLVSLESLVKKNSHCYTPWFRKIEMTLGGSGTPTRRGASLIGSSSSVDDGTNQNSNEPDLLNELYTRLEHIQPTIPDRVSTLLLESAGVRLEAGEGDVRLARLVGLAAEKFLSDILSDTMVHWKLSNAQNTGLLSKAGTPAPKDGVNALAPPEDTKPQVQSKASTSGKAEKRITLTVEDLLAALRDRGIHVARPPYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X416</accession>
    <name>A0A0R3X416_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8107</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020448">
        <property type="protein sequence ID" value="VDM32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X416"/>
    <dbReference type="STRING" id="6205.A0A0R3X416"/>
    <dbReference type="WBParaSite" id="TTAC_0000812201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000812201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000812201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133163" evidence="2">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000812201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21772" checksum="69206D48D2B3C3A8" modified="2016-01-20" version="1">MVATIIIVLYEFGTAVTADITPFFRPDIVFVPLEVPDQRPLKLAAPRITLPPPPPPPPPTPPPPRLTLPPVPPSSQLLRLRPSQISPPSQSNLHIQPVFAAPAIQPVILRPQLSLPIPQHLPPPPPPPPPPPPPPPPPPPPPPPPPPPPRLPSMHRSLHLPIICFQLTPLVHSYEECLLNLQPKLIRLFVDADAINCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4L2</accession>
    <name>A0A0R3X4L2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8341</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020487">
        <property type="protein sequence ID" value="VDM32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4L2"/>
    <dbReference type="STRING" id="6205.A0A0R3X4L2"/>
    <dbReference type="WBParaSite" id="TTAC_0000835601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000835601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000835601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000835601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29385" checksum="D70A21EECFF8C32B" modified="2016-01-20" version="1">MQIDLRGFLTFEWTLSLAYHGSYLNIDDILSTSNRLLCKTRISLPRIAPLLIGPIHTYKRPQSSTEGAIHDNDVSSGTRLEVPLWLISSIGSSRRQIFLIEIPVIYRHIRRLILIVLDILKGGFWFQEIYREIFAADPWVVDLRKRCPNFYSFGCHLSSLSLPGMPAVIATLENVFQRRIRNLMEASLNANKVSVMGLISRLEELEQALFRIGRNGRCSIDRWFSRMHERLEASTLAKATEAATEASLLPSKRSRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4T1</accession>
    <name>A0A0R3X4T1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8419</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020502">
        <property type="protein sequence ID" value="VDM32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4T1"/>
    <dbReference type="STRING" id="6205.A0A0R3X4T1"/>
    <dbReference type="WBParaSite" id="TTAC_0000843401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000843401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000843401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000843401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17593" checksum="CFEC766C3A5084C1" modified="2016-01-20" version="1">MTKVNESKAAFLAYPSTSRSLTQKVFIISTIVTLCTVVTIIALILIRSRKSQFWSMRKPAHLQRRCRRQSKWKRYDGFQPLNQDELRGLGSTFGSAIDEDDEDEEEAVMDSNTIIDIRKFGPQDSQQHSSKLSVQSCTPTRKNDLTSASSHHVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X579</accession>
    <name>A0A0R3X579_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CSRNP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8588</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020540">
        <property type="protein sequence ID" value="VDM33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X579"/>
    <dbReference type="STRING" id="6205.A0A0R3X579"/>
    <dbReference type="WBParaSite" id="TTAC_0000860301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000860301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000860301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000860301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="624" mass="68819" checksum="A4F58E46C0D197A1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5K2</accession>
    <name>A0A0R3X5K2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centromere protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8737</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020574">
        <property type="protein sequence ID" value="VDM33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5K2"/>
    <dbReference type="WBParaSite" id="TTAC_0000875201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000875201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000875201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6232397at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000875201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22452" checksum="E2FF1E477520D074" modified="2016-01-20" version="1">MAKKVSAKNSAPQNEEQLLLQIEKLQLIARLLTFRACRSEEVNKKSDLAVRKMQQNKLQLKQQSQMIVDDLEQVIFAILTSLKSFQAEARATLFSLQTQLQNSERMLLESNETICRLTEKVDSLEASMGESRRLFEISLQAIHITYFNCIERVFERLQELILADLEDLNPINDEVHETYANKFKALGLPCTFDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6D5</accession>
    <name>A0A0R3X6D5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9048</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020665">
        <property type="protein sequence ID" value="VDM33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6D5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6D5"/>
    <dbReference type="WBParaSite" id="TTAC_0000906301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000906301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000906301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133209" evidence="9">
        <location>
            <begin position="33"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="129"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="236"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="437"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000906301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="57844" checksum="50B634CF0A8A61D2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X742</accession>
    <name>A0A0R3X742_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9341</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020769">
        <property type="protein sequence ID" value="VDM34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X742"/>
    <dbReference type="STRING" id="6205.A0A0R3X742"/>
    <dbReference type="WBParaSite" id="TTAC_0000935601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000935601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000935601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000935601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="38705" checksum="BF6469ABB46BAA2D" modified="2016-01-20" version="1">MPSQEENSQANTSFKLKVKIVSAKLHKHTRSTALSRIRNPTFYVEFNTTSWDAPPPSDSPTNTDHITSNRGSTSAKTGWTPHFNSRTNFNININSHIEFLIVSQASVHASLNNGAGLVVGYSRLGIRDALRNHGNNLEDAAFALDILPLPTDQSVDGTTLTSLGTLNLLLTASARAVNAAIVAVNINQRPSVVVDVLVRDTFGGGVIIGSTYSRFYVTFEIAAVKSLSLQTSLSGIFFSILLRPTTINENSRSSTPTTTSSAAPSNIVTNGSSAAPATNASATAGDLLTVPRRQNGSRRRSAPNTEGLPPHWEQRTDPSTGRTYYVDHLTKRTQWEKPQPLPSGYATITPLFLCGFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7G8</accession>
    <name>A0A0R3X7G8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2110 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020836">
        <property type="protein sequence ID" value="VDM34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7G8"/>
    <dbReference type="WBParaSite" id="TTAC_0000949301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000949301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000949301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000949301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12687" checksum="8A546AB8300E823D" modified="2016-01-20" version="1">MMSLPYCHSCLPLETNHKGCRALRSLHSDEVSALQVVGPKEEMVDLHGEVVGIRWEVVSPTLDVVNRSGEAVATIGEVLDLQKAVADPSQDLVGTSVVVVDLHREDTGQDWEVACVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Q8</accession>
    <name>A0A0R3X7Q8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myb-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9568</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020893">
        <property type="protein sequence ID" value="VDM34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Q8"/>
    <dbReference type="WBParaSite" id="TTAC_0000958301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000958301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000958301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676304at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000958301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="54568" checksum="4A04BB5358601C1E" modified="2016-01-20" version="1">MDEFPCKTSEKSSPSFPEDADYDEEQLPGYTQSEPHENPQSAESPIDKLSSDVTLVADEEDDEMEGIKPLASNLDSPKPNIDMGDKKVHWTTRHVQLLLNRVEEHLNEFNVQKKHKSVWQAIGAEMEPYGFTTEHCYNKWKNLRRDVRLLVNNPSKVVRNAAILRQVARLILVIYPNVDASTMQVCDRSGIKSLPATPGGQGCANKTTTVDVHYSGFNSPHGKLSNGTPPRPNNSLYAGAGPVNVHSTPSSVEKSFCSAAKSGNVPATALFVDSLSNGDKMQSMFNQCPHSEPDSTGHFQLPFNQTAAALFFQSQLFSDLVKQQQLKNQMDSKSQDQVHDLSATQNGSSNTFSILQQALSNSPCSDLNALSVITTNLINSMAGLTPQVNESECPSANSNNGNNTISANSTNANPLLGLFPNIPLSLLERFAPNSCEITEIIESLRAEDDAQFRVADMMSDAAEQLRRACQRRQAALDKLLDLVKRQANGGSSASDTGNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X822</accession>
    <name>A0A0R3X822_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9682</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020978">
        <property type="protein sequence ID" value="VDM34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X822"/>
    <dbReference type="STRING" id="6205.A0A0R3X822"/>
    <dbReference type="WBParaSite" id="TTAC_0000969701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000969701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000969701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000969701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13347" checksum="46C13456E500C6B2" modified="2016-01-20" version="1">MSWNEIVDSLLKYNGASCACLAGIDGNIWASSPDFKPSQAEILKMIKVATGTEAESFTVNGKKVITVKCGDNELSATGNDYAVDVRVLKTMVIITGNSKPKDIPGVNRLLATAGNAMAEHLSHSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X888</accession>
    <name>A0A0R3X888_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9748</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021021">
        <property type="protein sequence ID" value="VDM34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X888"/>
    <dbReference type="STRING" id="6205.A0A0R3X888"/>
    <dbReference type="WBParaSite" id="TTAC_0000976301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000976301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000976301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2624652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000976301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="568" mass="60292" checksum="206826E616200D07" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X891</accession>
    <name>A0A0R3X891_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS9751</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01021024">
        <property type="protein sequence ID" value="VDM34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X891"/>
    <dbReference type="WBParaSite" id="TTAC_0000976601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000976601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000976601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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        <property type="term" value="P:sister chromatid segregation"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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    </dbReference>
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        <property type="entry name" value="TopoIIA_CS"/>
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        <property type="entry name" value="TOPRIM_C"/>
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        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
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        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
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        <location>
            <begin position="454"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="17">
        <location>
            <begin position="714"/>
            <end position="1195"/>
        </location>
    </feature>
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        <location>
            <begin position="1373"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1250"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1378"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1394"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000976601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1444" mass="162509" checksum="D0A2A2F1A2AA9C5B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAH1</accession>
    <name>A0A0R3XAH1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10531</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021810">
        <property type="protein sequence ID" value="VDM35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3XAH1"/>
    <dbReference type="WBParaSite" id="TTAC_0001054801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001054801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001054801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001054801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="34883" checksum="627C611F98B6AC28" modified="2016-01-20" version="1">MTQFLPPNLLALFAPRDPIPYVPPIEKHKNHRKLPYTGVAQFLGEFEDPSETPVSSRIETREERKARKRKERQEQANYKLERDLALWNPKKLVSGTTNAYNTLFVARLNYDTSEHKLRREFEVYGPIKKIFMIKDAATGKPRGYAFIEFEHERDMHAANKDANGRKIDGHRILTDIERGRTRPDWRPRRLGKGLGKSRSGPSDARRDERRRDDDRDRDRERERNRDRDRDRRRRSRSRDYRDRHRRSRSRERRRSRSREHGRRDRYRRDEMSQYGEYGAEIKAEYNGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBF1</accession>
    <name>A0A0R3XBF1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10861</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01022385">
        <property type="protein sequence ID" value="VDM35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBF1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBF1"/>
    <dbReference type="WBParaSite" id="TTAC_0001087801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001087801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001087801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001087801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54430" checksum="8A928F0738C5ED9A" modified="2016-01-20" version="1">MTSRHISLTVEGGEECALKQLTSNLLLLSIILFLIIELQLLASNMDRFLQNDTQPVEVTEGNEYTLDEEDLTPSMQCRWPPPDIKSIMVNKGFNITLCVRSSRHASAHKRVKKYALQDLFALSKFRGSITFEGLSLLPHRFWERVKKPQIYLTYPQDVPMSDIVEAVKGGYRVPEMPNYNFPITILSTPKSICQKEGEKYDLVIVVKSSVLAWDARSSFREYMRHEIMRNKQLKVGVIFSLGLPRRHGKRVFDRDGHTIYLPGPAGNMLDIYDGRAAEVMAIINEEIRKYDDIVLADYEDTYYNLTWKTVTNYRWMSAFCRKEDVKLFMTIDDDHRVNLSMVADFIDRIPVYIRRNSLFGKVAKTDRAYRSPWKKLYLSYREFPWDVMYPYLRGFAHLVGPDIVADVAIATAYTRYNYAPEDVYLGMVAFKLGIPNFNEPTMYGHDDYKIRNKKRNPAMVALTKFFPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC41</accession>
    <name>A0A0R3XC41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfate_transp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11101</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022962">
        <property type="protein sequence ID" value="VDM36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC41"/>
    <dbReference type="STRING" id="6205.A0A0R3XC41"/>
    <dbReference type="WBParaSite" id="TTAC_0001111801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001111801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001111801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001111801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15002" checksum="670A459965143082" modified="2016-01-20" version="1">MNGFEVDRLPAPVVPTFSYFSDLVPDIFVIAIITFAINAGLVKTYAAEFGYDVLDNQIASLISSGIFVIILFFIAPYLESLPRAVLGCIVCVALTSTFKKVLDLRRLWKVSKTDAVGLVLCPFATSLFLIHIALNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC97</accession>
    <name>A0A0R3XC97_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11157</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023091">
        <property type="protein sequence ID" value="VDM36137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC97"/>
    <dbReference type="WBParaSite" id="TTAC_0001117401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001117401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001117401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001117401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8189" checksum="D69413701A12ABD2" modified="2016-01-20" version="1">MLADNIRHQQRGYARPSSGILATGRCESGRAKVSLETKNRVRRMGGGKLGSAMQWCERQYELARALNLLLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCF0</accession>
    <name>A0A0R3XCF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FIST_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023215">
        <property type="protein sequence ID" value="VDM36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCF0"/>
    <dbReference type="WBParaSite" id="TTAC_0001122701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001122701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001122701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001122701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8863" checksum="94A768E6E1EB7C1D" modified="2016-01-20" version="1">MLLLNVDQQCSLAGKDNSEGPDAYEQVKFLCVRDALVGTYDLLQLRTAFPYVLCLGEMKGREEAGVYSGDSIFGVERLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCM8</accession>
    <name>A0A0R3XCM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11288</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023503">
        <property type="protein sequence ID" value="VDM36268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCM8"/>
    <dbReference type="STRING" id="6205.A0A0R3XCM8"/>
    <dbReference type="WBParaSite" id="TTAC_0001130501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001130501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001130501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512616at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF42">
        <property type="entry name" value="G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001130501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24709" checksum="C122117C939F71BE" modified="2016-01-20" version="1">MPSLVPLLLLLLLFLLRLLLLVLHAALLGVFFRLYAASGLIQRTDPDARSLSKRRRYIFGFDIEEVEAEICRGRRLRCRYCGNPGACVGCTKRTCPYSFHLPCLYDSKGFVCFKKSFEAFCYKHCPKQDLLPRLLECGDDPPICCICLFSVIPDDDSEKNSASVNKCSKASAVLRNYASSLDQDLVHKHSVKRLRFPLFFYVADAVGLFWLLFFAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDL9</accession>
    <name>A0A158RDL9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS911</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000128">
        <property type="protein sequence ID" value="VDM17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDL9"/>
    <dbReference type="STRING" id="6205.A0A158RDL9"/>
    <dbReference type="WBParaSite" id="TTAC_0000091001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000091001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000091001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="258"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="9">
        <location>
            <begin position="616"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1103"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1103"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000091001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139414" checksum="3AAA371E7F6400A7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDT7</accession>
    <name>A0A158RDT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6056</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDT7"/>
    <dbReference type="STRING" id="6205.A0A158RDT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000607101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000607101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000607101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="3"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000607101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="792" mass="86001" checksum="D7CCEE6DFD9BB5CF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE56</accession>
    <name>A0A158RE56_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6659</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020313">
        <property type="protein sequence ID" value="VDM30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE56"/>
    <dbReference type="WBParaSite" id="TTAC_0000667401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000667401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000667401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="3188"/>
            <end position="3526"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="11">
        <location>
            <begin position="3588"/>
            <end position="3620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000667401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="3620" mass="407079" checksum="B5694CBD233EF0EC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE95</accession>
    <name>A0A158RE95_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6909</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE95"/>
    <dbReference type="WBParaSite" id="TTAC_0000692401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000692401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000692401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="250"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1692"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1755"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000692401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1878" mass="212653" checksum="79950FB14DC09A11" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RED5</accession>
    <name>A0A158RED5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microtubule-associated protein futsch-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7096</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020345">
        <property type="protein sequence ID" value="VDM31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RED5"/>
    <dbReference type="WBParaSite" id="TTAC_0000711101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000711101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000711101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
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        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000711101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1689" mass="182387" checksum="620D21DFD8F2F270" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REF2</accession>
    <name>A0A158REF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF5917 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7182</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020351">
        <property type="protein sequence ID" value="VDM31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REF2"/>
    <dbReference type="STRING" id="6205.A0A158REF2"/>
    <dbReference type="WBParaSite" id="TTAC_0000719701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000719701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000719701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="721"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000719701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="946" mass="105523" checksum="0B3FAD3BB2894582" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="9">Atherin</fullName>
        </submittedName>
    </protein>
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    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A158RFA9"/>
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        <property type="gene ID" value="TTAC_0000938201"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
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        </location>
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            <end position="417"/>
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        <location>
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            <end position="465"/>
        </location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000938201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="524" mass="55285" checksum="46FA83A50EF6267A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ER33</accession>
    <name>A0A3P7ER33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005419">
        <property type="protein sequence ID" value="VDM25710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ER33"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="146" mass="16490" checksum="4F808227A7926371" modified="2019-02-13" version="1">MRLSDPFLAVEKAIRSNISEVMDKLTYLLADRIARIMQSWKPQPPTPTDEMRSVFKCISKLTDSTSDILSSEMLTNLLLRVHAEIKASLRSRLTDLALFPDGGPKQGLVNSELVIYMKFLCALTPTLAQFTDECDDIWPSRIAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERB0</accession>
    <name>A0A3P7ERB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005464">
        <property type="protein sequence ID" value="VDM25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERB0"/>
    <dbReference type="OrthoDB" id="6267135at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="232" mass="27098" checksum="DB96073FA14251C8" modified="2019-02-13" version="1">MAFIQLKGLSFPVGQKTTEMESVDKQRHSKQMDYMEKALCEATTERDEVVGRISQLKRRLEELQCSQVQIEQRLSERNEKLKKSTEETNGLRNQLEARQRMLEETESKLVAARQRNSELEAVYQRAEVSIEETSRRLQQEQEGCGRLQNELQEATCERTKMQQEIEELRKAKSQLQKSNKYLEKKYMMTVTERDEVNSNCNRLANDIKSLEQKLKNAEGEIASLNSKFQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ESM8</accession>
    <name>A0A3P7ESM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000890">
        <property type="protein sequence ID" value="VDM19367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ESM8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="61" mass="6263" checksum="12032A7C71EB14EB" modified="2019-02-13" version="1">MNVSISAAAAVVVVVVVVVMVLVVVVVVVEASVPAFLQTTALSSPRLVISSTQVIQRMVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F4N3</accession>
    <name>A0A3P7F4N3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003383">
        <property type="protein sequence ID" value="VDM23884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F4N3"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM23884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="218" mass="24715" checksum="2C44B216DB382D21" modified="2019-02-13" version="1">MLLHAHYCEETSRFDFETTRHLYSDICEAFPGCEKAHFRLAHYVDEARNQSGNQHDVLLKVALENYGQALACGSQFIFQSMPRFLSLWLDYGAEVAKMQQRQQQASATSIGRRGTNQKSTDGNTLDTFNEVQNLIRQSLSKIPPFQFYTAIGQILSRVCHEHPAVIAILIDLIARIVLAHPQQTVWSVVSLHEDSSKTTVQVYPGKFCLREIMLGSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F5F1</accession>
    <name>A0A3P7F5F1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003655">
        <property type="protein sequence ID" value="VDM24174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F5F1"/>
    <dbReference type="OrthoDB" id="6284625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="121" mass="13255" checksum="97A3F7B37085DBF2" modified="2019-02-13" version="1">MDDSSAVNPTANLVPANGGGGEHRLLFRRPALRVTKVSPSDVGRRICRVVRRSALFLLTTLLFAVSMNIFFNSIKWFFHLPQNLTTGNGTVEIDGVSQVASKPHLLLLNSVVSQQIARQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCP1</accession>
    <name>A0A3P7FCP1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronic acid decarboxylase 1</fullName>
            <ecNumber evidence="5">4.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-glucuronate decarboxylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS8976</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:23917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020644">
        <property type="protein sequence ID" value="VDM33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCP1"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000065">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="18">
        <location>
            <begin position="65"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="387" mass="43866" checksum="F5561C9F496E9AF3" modified="2019-02-13" version="1">MRNDMPKNQLMGSSFRNRLAERTGPKKMVSRLSRKDFKISAERYKKRIIVSSLDGLKLNCFNFQVSGGAGFVGSHLVDRLMHQGHFVTVLDNFFTGDRQNIEHWNGHPHFAFIQHDVSNPIYLEADEVYHLASPASPPNYMTNPIKTLKANLLGSINLLGLARRAGATFLLASSSEVYGDPTMHPQSETYWGNVNPTGIRSCYDEGKRAAESLAYAYFRRENVPVRVARIFNTYGPRMQFHDGRVVSNFILQALSGQDICLYGDGSFTRSFMYVSDLVDGLIRLMNSNITDPVNLGNPHEFTIRELASIVKNLTESSSKIVNCPEALDDPKRRKPNIAKAKNLLHWEPKVQLWEGLRLTIKAFRESLHNNSILHRPEQPHLHGNQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FDM1</accession>
    <name>A0A3P7FDM1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020763">
        <property type="protein sequence ID" value="VDM34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FDM1"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="221"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="347" mass="38697" checksum="9D4C669B90FA4A1C" modified="2019-02-13" version="1">MTFDSGLSESIDFPTENRLLSSSGVNSTVSNSINSSLRHQGITAIKRDESSFAASSFLHSGNEIQPFIPSMNESIDVNEYRDEIERESDLHFLSSDSGFQVAINSSNGSTLKGDLSSNNISSHSLPSGYPAINTSQHYSYQTPVQFPHVSVINSHSTLGQVLTRNSDPNAAPDSLNSLIRYQSDPTSAPTISVSDTAYSEKNIRSSKPQRLIKRQDVKQNKGRGEGNKLLSTRATQILEGWYEANTEWPYPTKAEKQMMASAGAITIEQVSRHAYLLRRQAYIVNSWFANRRNRSQNTRPKKNMIKLVNALSGLCDEYQEVSRGIISSSDMKNRILALINYHLQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FEJ8</accession>
    <name>A0A3P7FEJ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FEJ8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="176" mass="17684" checksum="3CC334CC845A1A6D" modified="2019-02-13" version="1">MKREKAELSAARFPSKKRRTIAHTGSPLTLSPIRVPPKPAKPITSASTPSGLFHRSSGGGVVAKEAGDSTASPTPPHSPDTSGGGGDTLPPTTGIPPMLLTTTAGREKAETGYDSSAPSSAHSSAPPSPGLLPPNGSSKAVMGEAAEVRSTSRRELLGSCSSSGSSDDEVTAVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFP7</accession>
    <name>A0A3P7FFP7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate kinase</fullName>
            <ecNumber evidence="4">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS5520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:18159"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01007823">
        <property type="protein sequence ID" value="VDM27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFP7"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="114" mass="12575" checksum="1E6759BFA43EE475" modified="2019-02-13" version="1">MGFGDKVRLTSNKEFENKCSKSMIYVDYERIVHVLHEGSKVFIDDGLICLVVQQKGPNYLDCVVENGGKLGSRKGVNLPGAPVDLPSMSEKDKEDLQFAVDNNVGVDEFIPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FIE6</accession>
    <name>A0A3P7FIE6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020392">
        <property type="protein sequence ID" value="VDM32086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FIE6"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="432" mass="46934" checksum="4CCC9B9FFF7AD86A" modified="2019-02-13" version="1">MANLDTKSCGKIGTYALIYYFTTTLMAVILGIVLVVAIHPGNPAIKENHVSTTTSSKTSPHTLDAFLDLFRNMFPENVIQACTKQVLSQMKNVTVQMKVHEASTCKHLSYPSNNSIDVAIVGLVTFSVAFGLGIASMGKQGRLMLDFFIIMNEIIMRLVRVIMWYAPIGIIFLIIGQIIAIDDLMSTVTGLGLYMLTVISGLAIHLFLTLMLMYFIICRKNPLLYMRGLFQAFFMALGTGSSSATLPVTFKCLEENLGIDARVTRFVLPIGATVNMDGTALYEAVACIFIAQINEYALSIGQLVTVSITATLAAIGAAAVPSAGLVTMVMVLTSVGLPINDIALIFAVDWMLDRIRTSINVMGDAFGAGIVAHLCREQLRVPAKRLNSISVAVPRTKWNDKQEDSADECEGEGSNHQDISMELVEASVAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FS80</accession>
    <name>A0A3P7FS80_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020363">
        <property type="protein sequence ID" value="VDM31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FS80"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF34">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="115"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="403" mass="45830" checksum="1345C34BE8E5B1E7" modified="2019-02-13" version="1">MGEMEFPPAFHKEMESIDAVNGTPAVLTCQLNRSLSPSEIVKVSWLKMPRQLLARGRMKITTNERISIVPQASENVFQLRFDPVVKEDGGEYRCVYNHKTGVKYKVVVVNIQVPPKVDIDPRGEVELLEGEYAFVVCNASGTPYPQFRWWMLPLATYQKHCAQQAPGLYGETEVTVTFASQTSHPFSPFALQPSTIATSSHLTLVPVHEIASKYKQNIFLRSGKLIINAVNRDMTGWYFCEAHNSVKPSAIEHTLLTVHYAPRVFLPQREVFFAPFGNVSLVIAYLHRYLLTTVKTVEGLLYQLEGQSKHGFGDSLTYLDTPTATRKDAPKKLRERFRSINLTQSSNDLTLYGRRVRSVLHVWVSEAKHFGRYSCRMQTRHGLAEGFIRLRNKGKYFPFLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H801</accession>
    <name>A0A3P7H801_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1304" mass="143506" checksum="26AA4827DE809B1B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H880</accession>
    <name>A0A3P7H880_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H880"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="68" mass="7880" checksum="4EC08DF2E0B6271B" modified="2019-02-13" version="1">MYLTRPVKSGIGLYHPTSILNSNELNRAMKEGWVKLAFYIMSFFGYLFGYVSFLYTLLNKPSCLFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H8W6</accession>
    <name>A0A3P7H8W6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020306">
        <property type="protein sequence ID" value="VDM30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H8W6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="79" mass="8753" checksum="1CF966638811A297" modified="2019-02-13" version="1">MPCCVRSFSCIMGLKETVEKLFAELDKDKSGKISCAELKAALQSYSAEPLDDSHVKAFFDKLDSNKDGELSLDELMALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HLI9</accession>
    <name>A0A3P7HLI9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023242">
        <property type="protein sequence ID" value="VDM36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HLI9"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="40"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="273" mass="30554" checksum="2AA38238104C2E01" modified="2019-02-13" version="1">MVQSRIKALERMPKLVPPEKPVKIVFKLPECETITLQPLVQLEGVYFRYVPETPLLENVDLTVLHNSRICIVGENGAGKTTLLRLLLGDLTPIKGLRHCHRSLRMAYFSQHHVDQLDLTVSSLEFLMKKFPGNTEQCYRSQLASFEIDSLLAERPIGSLSGGQKSRVVFAAVCMLRPNLLILDEPTNHLDIETIGALGESLNNFNGGVVLVSHDERLIASVCTECWLCTRHCYTDNKADVCLPTASRVRVLAGGLEEYKKAVRRELETGETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI65</accession>
    <name>A0A0R3WI65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS274</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI65"/>
    <dbReference type="WBParaSite" id="TTAC_0000027301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000027301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000027301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6038751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000027301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15209" checksum="95E0D8C70610ECCB" modified="2016-01-20" version="1">MTAASQSYSLRAQNRQWRIEIPEFNNREDELKSQYFQFGYYVPLERRWQSYQRHRSLPPCTLRDAIDIQRENDYIQLKHSQDKCKSMHSILSIVVSADHRFPTVADQILLSVMEYCPNYKYNLLCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIT2</accession>
    <name>A0A0R3WIT2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aurora kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS529</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01000049">
        <property type="protein sequence ID" value="VDM16588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIT2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIT2"/>
    <dbReference type="WBParaSite" id="TTAC_0000052801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000052801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000052801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM16588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000052801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33881" checksum="12E79D0061150129" modified="2016-01-20" version="1">MSLVRLQSTFCQESSQNSEPPISRLSDFFIGRPLGNGKFGNVFLARTRKEDFVCALKILFKKQLVKCGMEHQLRREIEIMCHLRHPHILQLYTYFHDETKVYLVLEYAFYGQMYAHLQLEKRFSERKAATYVYQLCDALKYCHSRYVIHRDIKPENLLLGFYNELKLADFGWSVHAPSLRRRTMCGTIDYLPPEMLLGHCHNERVDHWAVGVLCYEMLSGNPPFVHKDTKETYARIKAVKYKFPSVITPLAQDLISKILVLHPSNRLDIDSIIQHPWIQTYAEKEKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJA3</accession>
    <name>A0A0R3WJA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS741</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000087">
        <property type="protein sequence ID" value="VDM16921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJA3"/>
    <dbReference type="STRING" id="6205.A0A0R3WJA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000074001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000074001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000074001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000074001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="39995" checksum="B962C885E7A00C4B" modified="2016-01-20" version="1">MDDSANDHICGSHGRDTSLLNVVLDELPQEMCKSNDFTLKPLAIPASPSSTTPQVPKSPCCASSREAGNSCSQFHDLSYVPHVCSTLNMALNLEDSLRLIHGIACSKLDMHLRQMTSVDVTNASSSYALSLCCSRTGVSCLCAVGPCSCSSALPSSSPQQLTASASCQTDDLTDTHALEALSPSSLFSLSEKQSVDLDKATISQDLSFLNSLIQPSSSASSTNDLSIQPAPQTLVDPPPVGKNICPSKMLPFSCSFCGRIYRQKVHLRKHVMAQHTKQKPFFCPHCAYTTVEKSHLTVHIRTHTGERPYICRVCHYSSSQNCTLKSHYLRKHPESKINCVTCGGTYVTELEYQNHLKNCVSTFDRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJE1</accession>
    <name>A0A0R3WJE1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS789</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000098">
        <property type="protein sequence ID" value="VDM16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJE1"/>
    <dbReference type="STRING" id="6205.A0A0R3WJE1"/>
    <dbReference type="WBParaSite" id="TTAC_0000078801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000078801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000078801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000078801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13151" checksum="D9EC3EF91186575E" modified="2016-01-20" version="1">MSDIWDIWNGSIYFATPKKRRSIEVRRARKFLSLSTSRLLVRCYDEVRRETNALRASLKSVREGLPHDNETQFLYDQENFGTSGAYIHRVDRKRPSWFPANLLGLSSSNSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ9</accession>
    <name>A0A0R3WJJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS850</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000112">
        <property type="protein sequence ID" value="VDM17076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJJ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000084901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132915" evidence="8">
        <location>
            <begin position="21"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM17076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56448" checksum="785FFF7E92CEEEE4" modified="2016-01-20" version="1">MNTHCIHLRLLVVFYNTSEAISNREGSGRSYNVSVFVANMLSYGSLVNNQVCVYICSHKHVFFQKKLSFLFQEITEEEEARIRAEEELEKQRHDEEEQKWLERERIAQELFMQKKALEESKRQSKSLEEIVETPKEGTEEEPQLSEDIQSNLLQRLRDGVEEISENLPPYHRPEPPLDNHFAPPYEHTLKNTELCGFFWKTGACIYGDRCSRFHPTPPIESADLKVLQSSFYPPCLVLILENMFDNFSLRYDPLEVDESQLQAEYEDFYDDVRPELESTCGGITALRCCRNAADHLRGNVYVQLTGDTAMAIAAATRLNGRWYAGRQIITRLAYLGGGWKAAVCGLYLRDLCPKGDRRCNFLHLFLNPHESSGDLLAALNRGIAELPSRKKETKRFVAYMLVGCVTSESVSQIAFVIPPFPHYRSSRGRSRDKDKSLVNRRRKRRRSSSPHSGSRKRHRRRHKERHHRRKRDKHVSRSRERPSSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKG5</accession>
    <name>A0A0R3WKG5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1205</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000215">
        <property type="protein sequence ID" value="VDM17621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKG5"/>
    <dbReference type="WBParaSite" id="TTAC_0000120401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000120401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000120401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6233064at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132937" evidence="2">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000120401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31765" checksum="95F7A325502F08BB" modified="2016-01-20" version="1">MIHLTPFLLLFLSLFLTVSLTAASTIVPRTSSELETADTEATNMHKDFFNLLNGPLIPAAFMKSRGARNKLRCNKASPYVDMDSEVFVEELPSPQIESEIREIINTFVETLKHDKSWFVSLLFQIRKEQKRRESEACSEAECIYKIPCYLSQSFLSLSMYSEMLKRARVKEGFDLLSRRRRSLDGLEAEAEYSSLVSGGKAPVTNCTGIFANYCYNSISCIYVSVLESAACSCMPGYTGLRCDLYDLSITLATLSQFRTTTVDIEVLRPEDSATMYSVLDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKJ5</accession>
    <name>A0A0R3WKJ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1239</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000230">
        <property type="protein sequence ID" value="VDM17676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKJ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKJ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000123801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000123801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000123801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978072at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000123801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26765" checksum="BEB07D3F2F3C72D7" modified="2016-01-20" version="1">MYCTVSWILKKEGLTFGVVNAGQDVYFQPDPNGPSVYFSDGPLSYRYRLHGGVIKFGSTSTVGSEHQIDGKTFPGEIQLYAYNSDLYHNFTLAVSRPNGLAAVSLFLQVGQSPAPDISALLSTVAEVKLKGHRRKLYGLILQTLLPNTNEFITYQGSLGFPACHETVTWILLNAPVTVTEDQMKGLRGLRMSEFKNAGAMADNYRPIQKSNNRFIRTNIYFNASDYRQCALPPRLSYECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKV3</accession>
    <name>A0A0R3WKV3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1358</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000275">
        <property type="protein sequence ID" value="VDM17864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKV3"/>
    <dbReference type="STRING" id="6205.A0A0R3WKV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000137101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000137101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000137101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000075">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="88"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="697"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000137101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="743" mass="88504" checksum="B1C28EF21C2A0AE8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL67</accession>
    <name>A0A0R3WL67_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1490</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000343">
        <property type="protein sequence ID" value="VDM18096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL67"/>
    <dbReference type="STRING" id="6205.A0A0R3WL67"/>
    <dbReference type="WBParaSite" id="TTAC_0000150301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000150301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000150301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000150301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36576" checksum="A88A8B3AB849F733" modified="2016-01-20" version="1">MDFQHRVGGKTGSGGVASESEANRDRRERLRQLALDTIDLEKDPYFMKNHLGTYECKLCLTLHNNEGSYLAHTQGKKHQYNLQRRAHEQAKEGPATLQPEKAKVEPKKFIKIGRPGYKVTKQKDPETGQQSMLFQIDYPEIADAAGVIPRHRFMSAYEQHVEPPDRKWQYLLFAAEPYETIAFKVRSREVDKDPKKFWTYWNPASKQFFLQVEFRYFHNFAYKLENQSTSSAMIRELEMQKARAQQAQLQLQLPPPPPPPPPPPAIPSFGTTPFGISQASQPPPPPPPSLTGIGVGVPQPPPPPPPPPLLAAPPPPPPPPPPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLU6</accession>
    <name>A0A0R3WLU6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dystrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1721</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000467">
        <property type="protein sequence ID" value="VDM18440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLU6"/>
    <dbReference type="STRING" id="6205.A0A0R3WLU6"/>
    <dbReference type="WBParaSite" id="TTAC_0000173401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000173401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000173401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270259at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000173401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50337" checksum="035ADCCA5327A4CB" modified="2016-01-20" version="1">MSSYFTSSLNRVVSNIKRTVSELVNDTSSRGGGLDKTNCLLDSNSFSTVDIIPAHSRRKSQPERLKNSPTRQGKNDTTKRLSLVEIFGDNAETSSAPDSNLGEVDTHSNEVLIPQEEANKSNDMSETSKRLLLSESMKRNPPSLPSLSVLPEEENGGKSTANSSRKFVSSVAPDSAVGSASSGPSNVGEQSDATSSTLPIEQKAKNADSSDPADAAVEEVRQCWNATSAQVKARLDELEKMMAATEELKTLERELDRWLSRAETDLANALSNTQDVAEKKRIIQDIIDRLPTGETKFTTHQNKCEAILAKYSKEDTQKFRADQEAIQMRWSQLVSRLRESLEGAPQPDSDLIEIPIASRTRAPESDLQKIVRLRTVSSQQSGTYNSSEHFIQPESRSMESSMIDNYRGGGNGQAPTCSTLGRHAFDQKPPLLGESYCTHQLSRSADIRSRPFDSSRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLU8</accession>
    <name>A0A0R3WLU8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1723</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000469">
        <property type="protein sequence ID" value="VDM18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLU8"/>
    <dbReference type="STRING" id="6205.A0A0R3WLU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000173601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000173601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000173601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1695393at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040362">
        <property type="entry name" value="RELCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32059:SF0">
        <property type="entry name" value="RAB11-BINDING PROTEIN RELCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000173601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="718" mass="79578" checksum="305482D15124A351" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM41</accession>
    <name>A0A0R3WM41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000530">
        <property type="protein sequence ID" value="VDM18556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM41"/>
    <dbReference type="WBParaSite" id="TTAC_0000182901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000182901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000182901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000182901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34177" checksum="89566D282C5BDC39" modified="2016-01-20" version="1">MVNGESKCDRKRHDLWLEGLELSCYGGSTKQKWLPYYISVCRDGHASGAVREVAQSNAVKRKRSRILHPLTIHEVRVALQNRRFRGSAVNSRPCRTTLCASSTAIGTTALQYRSSPGCDLKEKTQTSALPSGGTGHFLVPVVSSGTIRPPVSNLPFPLREDEIVQSLIVCTAWSVFHARRHQHSLTHPYRMRWYGLADPSIILTHCFGAKQSARSARAAAVAAPMTSGSWMPPKRHTKPSSFAVRRPLIMILFYIQLSAVPPLQHYDRSPMYPALLFVLELTQQQIYLFIAAHLHGDSRGFMDGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMD6</accession>
    <name>A0A0R3WMD6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1911</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000599">
        <property type="protein sequence ID" value="VDM18651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMD6"/>
    <dbReference type="STRING" id="6205.A0A0R3WMD6"/>
    <dbReference type="WBParaSite" id="TTAC_0000192401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000192401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000192401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000192401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="630" mass="70087" checksum="06284AB0D80EDB6C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMH8</accession>
    <name>A0A0R3WMH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1953</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000633">
        <property type="protein sequence ID" value="VDM18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMH8"/>
    <dbReference type="WBParaSite" id="TTAC_0000196601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000196601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000196601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155648at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132893" evidence="2">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000196601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25430" checksum="293073478DF56EE5" modified="2016-01-20" version="1">MVFNLCLIFVTVFVLGSGVNGKSDIGSSLPQHFRWSQVGSQSIQLSWDDHKVNGHTPDQVHLFVIPRSSSLQRVEKQVAFSAKTVILEGLHPNTLYYVILTVSAGEEEVLNHIGTIRTKKYVYKMTPLPQHFRWSNVGPQSVRLSWDKHTLDGYTPTLVVMTLKSRKPDEFVVEKFGDFNVGSVTLGGLQPDTVYDWEMSVLWGQLILMNRLGEIKTSKAGAGGVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMQ7</accession>
    <name>A0A0R3WMQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2032</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000698">
        <property type="protein sequence ID" value="VDM18772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMQ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WMQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000204501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000204501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000204501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="45"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000204501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="658" mass="72125" checksum="1E037B0DAA57DE15" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMQ9</accession>
    <name>A0A0R3WMQ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2034</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000700">
        <property type="protein sequence ID" value="VDM18774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMQ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WMQ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000204701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000204701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000204701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23803">
        <property type="entry name" value="UBCc_UBE2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000204701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32370" checksum="0A0CDEBBC4D7304E" modified="2016-01-20" version="1">MAAGGNVRGSAVKALQKEFKELAETPVEGFKVTLVDESNLFVWDVAIFGPPQTLYEGGYFKARLSFPPDYPYHPPSMRFINPMFHPNIFENGNVCISILHSPGEDLFSDEHPSEQWNPTQNVRTILLSVISLLNEPNIHSAAHVDASVAYRKWIESKGKEKGYEQRVRELVERTKLDAKWDGVIVPTTLEEYCFASRQQQSAAKSRQESEEAMLLDEDDYCFCGDDDEDLDDFDEIYGEAKNLDEVECEDKVVACHCVTDKSLPSKSGITTPSVKSSAEPNSPSTSFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN71</accession>
    <name>A0A0R3WN71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000840">
        <property type="protein sequence ID" value="VDM19195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN71"/>
    <dbReference type="WBParaSite" id="TTAC_0000220901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000220901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000220901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5793009at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF68">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000220901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22879" checksum="8309445DD0247BCB" modified="2016-01-20" version="1">MSAFVVRYCQVSGFGDASTTKAQSDVSTSSEPVGTNYHNPEGEQSFKVNHRSSGVSNSTNFTNVECPSCQRIYTKRSLDFHLKVCAIRQAEEAKRRNAIEAAIEKQKRGPSRPPGKPCYICGRRYTKSSWGWHEPKCQEQWNTWNSRLPKHLQHQDGLLVPDTDDETLTAVVEHEKAAGNSKFNKKDALEKVLLEASRVNALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNW9</accession>
    <name>A0A0R3WNW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shugoshin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001086">
        <property type="protein sequence ID" value="VDM20059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000245701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000245701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000245701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000245701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77411" checksum="AC98A67AD1B41A33" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP36</accession>
    <name>A0A0R3WP36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001159">
        <property type="protein sequence ID" value="VDM20286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP36"/>
    <dbReference type="WBParaSite" id="TTAC_0000252401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="23717" checksum="D3A27902AD243717" modified="2016-01-20" version="1">MSTQVPKVINEGLAALTTQFIISTGPASTTVVSADTFTTPTVPASALMTTATDDSTFTSRPIHTSKINTTRAFTPNNLFNTSTGPAATAMISTTSLVTLTTTCTSITELTTPTAATSESASTGRSTHSLVSSNTRLSSSSLLTTTLGDSELTPHLINDGDSTPTPSITAVLYTSLVAAFNLNLKSPLLVLCREFSSGLMEVGIKAKFGIPSVENYGTQQLTQDVVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPU5</accession>
    <name>A0A0R3WPU5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001489">
        <property type="protein sequence ID" value="VDM21118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000278501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000278501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000278501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000278501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8687" checksum="9E929EDD83C6EAB9" modified="2016-01-20" version="1">MRLSPAESSLALESVNAVDSSAGRYGGHIGFLIDLLPTQPTLLDRSVSEFVFTVFRHPESFSVTVTTDDAEDNGVLGGADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ82</accession>
    <name>A0A0R3WQ82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2907</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001664">
        <property type="protein sequence ID" value="VDM21483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ82"/>
    <dbReference type="WBParaSite" id="TTAC_0000292201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000292201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000292201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000292201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8228" checksum="A14A18EFE0BC77B5" modified="2016-01-20" version="1">MTADELSRRGNLDGSQAIGTELASAEVSSGFATSNVRVRPPTDHLWFNDDVESRQLRREAPLVRLEDEGEAADLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR58</accession>
    <name>A0A0R3WR58_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3233</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002101">
        <property type="protein sequence ID" value="VDM22209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR58"/>
    <dbReference type="STRING" id="6205.A0A0R3WR58"/>
    <dbReference type="WBParaSite" id="TTAC_0000324801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000324801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000324801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000324801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11598" checksum="7F67888CB49885E3" modified="2016-01-20" version="1">MARRSDKVDGQPKCNEASEPALGAAADPSSPSLRRRGQLSLWVQVAAIRLSHASCQQLCLPPTSLPKSHKYRFSPSPVPQSKKRLLPSGSSNCREAREAGDAVKEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR81</accession>
    <name>A0A0R3WR81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3256</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002133">
        <property type="protein sequence ID" value="VDM22251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR81"/>
    <dbReference type="STRING" id="6205.A0A0R3WR81"/>
    <dbReference type="WBParaSite" id="TTAC_0000327101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000327101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000327101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000327101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37577" checksum="E2B3835488D90BEE" modified="2016-01-20" version="1">MAKEWLALDANWHDPQAAFDTFRRRVFDYMCEGGTWACCTAGVRDVSCRDPPKPMQDVIFTLMDPTENMPVIFLFWWCANVRFSHPCFIFFSWVTFRRMDSSGDAFIALQLKRSILQFCPSPCLAKPCRWISGVDMPNVCKVVGPFEDDYECICRREFVWDQDTRTCKAINPCFVPIYAPCSTVGTLTCVALDMQHAKCICKAGYMGKDCAQPRNACLKRFNETEPNGNTNCGVAHGNLCNPVLGTDFYKCICTTGWIPSSQLPYDNCALLNDPCGTVTMEEEEAGAKDGTEITTPKVLESISCQHGGYCISSADFSRAACLCPTTVWGDQMYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRH4</accession>
    <name>A0A0R3WRH4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3349</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002290">
        <property type="protein sequence ID" value="VDM22443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRH4"/>
    <dbReference type="STRING" id="6205.A0A0R3WRH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000336401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000336401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000336401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM22443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000336401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="37591" checksum="FDA1BBCB64B48A84" modified="2016-01-20" version="1">MVQGDENRELLMVLIDLTPVWWGTYAHENLILPSFIECILAFVNCHLTLSPLNEVAIIGVTPEQTEFLWPSLTPLEEFEPQPCHYGQYEAFAILGETVRRKVQRLITSCESLACTVSFASAINNALCYYIRRCRELRPTLSLRNDSAPSNTNAIVAVEDISSLLTDSFHARILVVRAADDNPAQYLGLMNAVFTAQKLGVLIDACIIPPTRMSYSADDPLRQSSTTLQESSNSSLFQQAADLTGGIYLRIPRPAGLLQYLLSVFLPRAGLRSQLILPDCGGGTGAGVDFRSACFCHRKMVDLSYVCSVCLSIFCSFTPICSTCQTPFKIPIVAVLPPEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSE8</accession>
    <name>A0A0R3WSE8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS3673</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002844">
        <property type="protein sequence ID" value="VDM23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000368801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000368801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000368801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="231"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000368801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48592" checksum="DC972C8737A6CDE0" modified="2016-01-20" version="1">MLDCFWEVISDEHGVDPTGSYHGDSDLQLERINVYYSEASGGKYVPRCVLVDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVESVLDVIRKECESCDCLQGFQMCHSLGGGTGSGMGTLLISKMREEFPDRIMNTFSVMPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLTNPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRVLTVAELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMKEVDDQMLNAQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSVTFVGNTTAIQEIFKRVSEQFTVMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEAGIGDEEEEDEDGAMVEDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSL9</accession>
    <name>A0A0R3WSL9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3745</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002970">
        <property type="protein sequence ID" value="VDM23274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSL9"/>
    <dbReference type="STRING" id="6205.A0A0R3WSL9"/>
    <dbReference type="WBParaSite" id="TTAC_0000375901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000375901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000375901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM23274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000375901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="34434" checksum="D242C866149863F9" modified="2016-01-20" version="1">MAAFIAILNLPEIPLWLTLVVSFSAGIVAAIIVFFFVRPLIRRRVQRRLELMAAGKWDPTHKNSRGSYCKRIRDGIRDVFCKGQNVGGSASTDEQKNETGPSGDGTIGDVEIQTLPPVDVVESANVCRSPDAVTVTFNNETNRAPDGQVYDRPEEAQVFAFAQILTATFGSFVHGGNDVSNAIGPVIGLWIVSTTGNVLMTAKPAVWILFYGGVGISVGLWIWGRKVMETIGTDLTVITPSSGMCIELGAAITVLIASKAGLPVSTTHCLVGSVVIVGFIRSKMSVNWRLFINIILAWVVTLPMAGGLSALIMYVFTKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTB8</accession>
    <name>A0A0R3WTB8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aamy domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3993</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003434">
        <property type="protein sequence ID" value="VDM23934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTB8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTB8"/>
    <dbReference type="WBParaSite" id="TTAC_0000400801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000400801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000400801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="2">
        <location>
            <begin position="100"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000400801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="615" mass="66344" checksum="E37B212537ABF272" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTM7</accession>
    <name>A0A0R3WTM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4102</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003659">
        <property type="protein sequence ID" value="VDM24178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000411701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000411701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000411701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000411701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="21745" checksum="1B35BCCF73485118" modified="2016-01-20" version="1">MGVKKPKHFVHQQEQQQQQVPRTPSAVTSLAAQCQGSYRSCGHRHNSSKQSSLPKQKSPLASANATATLEGPVQRKKASKNVDPPKVFPIGTTGIGVSAAASTASLPPWQPRKPWTVTESHCEEDLRQALSSVAVENEVGSGGSGGQPGPPTTAWAGMSKSGASAVPHLGDLEFPPLSSAVGQHSVKPASGAGDSAFDLLPMWLMLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU02</accession>
    <name>A0A0R3WU02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PARP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4228</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003966">
        <property type="protein sequence ID" value="VDM24477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU02"/>
    <dbReference type="STRING" id="6205.A0A0R3WU02"/>
    <dbReference type="WBParaSite" id="TTAC_0000424201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000424201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000424201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049296">
        <property type="entry name" value="PARP1-like_PADR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21728">
        <property type="entry name" value="PADR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01335">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52007">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00347">
        <property type="entry name" value="ZF_PARP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000424201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38274" checksum="0F166ECA68A268AC" modified="2016-01-20" version="1">MDAGFEYQAEYAKSGRSSCRSCKNTIAKDALRIGVFVQSHTFDGKMILWHHCGCFFKKSQVLQTSAIKNFDKLRISGFSKLKVQEKFDLLDAIKNVELPSVKRGSYGSEKSENRLPTKKSKLPTGEKESSKYALKASFRKQSNKLWRLREQLDAEVSTSALVGLLESNSQLVPSGRAALLDAVADAMLFGALPHCPLDSAPLVCVDGGYRCSRLADHWAPCLFSATATDAASLARSPFHVPEEYHDVPFLRTYKCKPRVRLFTESSSASTGLFDKRTPLAGLHFLLDRGSFSDDATERHLAASIRSLGGSLLDTVSDCLCSFGLHEGCIFRLKCSVRLSLIMKQTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU09</accession>
    <name>A0A0R3WU09_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Dynein heavy chain 7, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS4233</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003975">
        <property type="protein sequence ID" value="VDM24492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0000424901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000424901"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:dynein light intermediate chain binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:microtubule-based movement"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
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    </dbReference>
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        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
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        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
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    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="DHC"/>
    </dbReference>
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        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
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        <property type="entry name" value="Dynein_linker_3"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DHC_N2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
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    <feature type="domain" description="Dynein heavy chain linker" evidence="14">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
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    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="485"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM24492.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000424901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="629" mass="71259" checksum="65177B04710C5D8D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU86</accession>
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        <submittedName>
            <fullName evidence="3">Indolepyruvate ferredoxin oxidoreductase</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004128">
        <property type="protein sequence ID" value="VDM24657.1"/>
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        <property type="gene ID" value="TTAC_0000432601"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000432601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19683" checksum="20D1AE3516B8F842" modified="2016-01-20" version="1">MALESRGDIYSPTGKLHGDTADSRNISDAAFKALQKAHHIGCRKPLLVLGDLTSGPKDAVWMQKDFPLLNAILGALHALYNPLELREAFPKRAKKFDSLLVFGASEKILKVAHAIEEGRRVARDIAGSDPERMSAPRIVEYLLNEFASVEEVIMKVEEVDASAYPLIAAVNRATAGKMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUQ9</accession>
    <name>A0A0R3WUQ9_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4484</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004568">
        <property type="protein sequence ID" value="VDM25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3WUQ9"/>
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        <property type="protein sequence ID" value="TTAC_0000449901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000449901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000449901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="19844" checksum="2129DC351FF1359D" modified="2016-01-20" version="1">MLVPYLLHRTTLVQGSSKGVGFIRFDQRSEAEAAILELNGYRIPGSSEPITVKFASCPSSTRLLASLLPPATPLAQLDATSLAAAAAAATASLLAVPTPPVANIGSTQFSEFPNRQLMAALAAAANFRRQQQEQQVAWLQNAGLGYHPAANPSPVLPSQRISWKNSGFAGGPVQSATASSLKISIMSMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUT9</accession>
    <name>A0A0R3WUT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WASH-7_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4516</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004645">
        <property type="protein sequence ID" value="VDM25095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUT9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000452901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000452901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000452901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000452901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15139" checksum="094D5FFE8F9A52C1" modified="2016-01-20" version="1">MEARNRLHEAFSGIYGYNYKVNHAFFFQFFNDLETYMAGRRGGLAQLVVSFFNQLRTSIVVLMEKAEVPTGSTVNPDSQRITCLSEALGKQNAFDLTDVHLREQFLQVYPPARMLVNSLAAGSKLLRTIVEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV85</accession>
    <name>A0A0R3WV85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MRG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4659</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004986">
        <property type="protein sequence ID" value="VDM25387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV85"/>
    <dbReference type="STRING" id="6205.A0A0R3WV85"/>
    <dbReference type="WBParaSite" id="TTAC_0000467501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000467501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000467501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="8">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="172"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000467501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34775" checksum="7924E50DD428BA9F" modified="2016-01-20" version="1">MSPVAHKYEVGDRLFCFEPDPSKAKLIYQAKVTQLCGFASSGRSRVPLYCVHFLGWKQKWDREVSEDLLMDINSFTRMLKQKIDELAIKIKDKEKRKERIDTVLMSAAKARDDVDWDSLPGTWKKDEVLSKARASSFSQESSQFQPQSEAQEEMELDPDSLAQSNFESLEAHANFAPKIKLPNTLYAILESHCRPFETARGSSVRPFVPVPSWCSVLHLLQTYLNAFPYFMPVNNSVGPNRGNNVLFPSIVLRERFSKAAAAEYMKTDRSRRLCAEFCSSVRILFDALLEEYLLYPNEQRKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVU5</accession>
    <name>A0A0R3WVU5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005547">
        <property type="protein sequence ID" value="VDM25793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVU5"/>
    <dbReference type="STRING" id="6205.A0A0R3WVU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000488501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000488501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000488501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285592at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000488501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="60" mass="6540" checksum="CE5AF90371600437" modified="2016-01-20" version="1">MATEDRGSRKKVPQVLATIENCMHLTSLLVQALSPTVAITPLLQLPHVGPTQLRQITHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW64</accession>
    <name>A0A0R3WW64_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 8">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS4990</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7 8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 8"/>
    <dbReference type="EMBL" id="UYWX01005875">
        <property type="protein sequence ID" value="VDM26012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW64"/>
    <dbReference type="STRING" id="6205.A0A0R3WW64"/>
    <dbReference type="WBParaSite" id="TTAC_0000500401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000500401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000500401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133021" description="Adenosylhomocysteinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="307"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM26012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000500401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48395" checksum="A5339F059BA4C8F4" modified="2016-01-20" version="1">SFGEVLFIFSIIFTCISADIGLAEWGRQEIELAENEMPGLMKLRAKYGAVQPLKGARISGCLHMTIQTAVLIETLTALGAKVRWASSNIFSTQDHAAAAIAKAGVPVFAWKGETEEEYAWCMEQTLNFEDGPVNMILDDGGDLTGLVHEKYPQLLSGIKGITEQTTTGVHALYKRLKEGKLKCVAMNVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKTAFVAGYGDVGKGCCQSLRSYGCRVLVSEIDPINALQAAMEGYEVTTADKAAKEAHIFVTATGCCDVIVGRHFEQMREDAIVCNIGHFDIEVDVVWLNENCVEKVEVKPQVDRYLLKNGRHIILLAEGRLVNLGCAHGHSSFVMSNSFVNQVLAQIELYTKPENYHIGVFMLPKKLDEEVAAAHLDQLGAELTELTKKQAEYIGVPIDGPYKSDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX56</accession>
    <name>A0A0R3WX56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Jacalin-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007076">
        <property type="protein sequence ID" value="VDM26715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX56"/>
    <dbReference type="STRING" id="6205.A0A0R3WX56"/>
    <dbReference type="WBParaSite" id="TTAC_0000534601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000534601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000534601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276199at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000534601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22002" checksum="2AB178B8F57BA5C4" modified="2016-01-20" version="1">MPVNVPEMPQRTARVTHSLHGIEEDVDPDVVWTPAYYGDVEDFDAKEEEVDANHNWLIFSTRDAHLLLKKGPHGDSYPITGRYDAHIDGRVVTGKLLSELIRSVHKEGEETEAKQRNRVSLVYYKDLQHYAGRAEMKALGREDTTTIVKKGEFGGIAVTSYPNEVSDGGHTSCTETIGVTSLGGLDVGLLISANDAVLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXA2</accession>
    <name>A0A0R3WXA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5377</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007234">
        <property type="protein sequence ID" value="VDM26836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000539201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000539201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000539201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000539201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15039" checksum="723457D5AC89B5C6" modified="2016-01-20" version="1">MDKLVNPANQCEDVRNAKDWHGKAMKMWLENLLCRRMEEEEEEGWGNVCPHHCFLNIQALCDSCRMVVDPFLPSPSPCTTLLTMQLQDASVGAHLTNFRLPNSSYVSHALTVSYRLRLSISASTSCLINNGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXA4</accession>
    <name>A0A0R3WXA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007242">
        <property type="protein sequence ID" value="VDM26840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000539401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000539401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000539401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000539401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14177" checksum="F2B7598B006F92F2" modified="2016-01-20" version="1">MILVVTFCAYKYPRKLAQCWLSLLANVYQAQSLLPSYPPSTTTTTTTAAAAAGTVTTTAATTELGDVDKANTFSLPTTQSPVLLHSSPFSTTTPPDLERLALRQELEETRCKLNAVSNLALYAFSVPRTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXC4</accession>
    <name>A0A0R3WXC4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007351">
        <property type="protein sequence ID" value="VDM26895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXC4"/>
    <dbReference type="WBParaSite" id="TTAC_0000541401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000541401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000541401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284270at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000541401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10010" checksum="37C8A0339F9C8BB5" modified="2016-01-20" version="1">METWIRALVAQGLEHWSSKPGVGSSSLPEGSAVVAIPFADVDITMAPTPSAFLAQQAVRQLSPLMLCTCMAPQLETHERSQGNDWMDRGWVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXC9</accession>
    <name>A0A0R3WXC9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5404</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007365">
        <property type="protein sequence ID" value="VDM26907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXC9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXC9"/>
    <dbReference type="WBParaSite" id="TTAC_0000541901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000541901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000541901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000541901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9250" checksum="09974B1B128D5652" modified="2016-01-20" version="1">MVWVVSSAFLPFTHRRKVQEINWQRKQEQMVAGETLTQLEEEWVSLVGKNYEIEQAILELEQELQVSAHPSLNEDAKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXK4</accession>
    <name>A0A0R3WXK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5482</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007692">
        <property type="protein sequence ID" value="VDM27071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXK4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000549401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000549401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000549401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000549401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15144" checksum="DDB123C22EE2BB45" modified="2016-01-20" version="1">GYAEFQFLYTNITDTGEYFCVAKTANGSAQSTSCNLTVLSEDNVVTDSQLPDESMIMNLAAMENQLAMNGTSRREEEVKFTSPPQFLRPLIPQVGLKENERAKFETFVQPANDPSLTVDWFKDGEPLKTGILFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXL8</accession>
    <name>A0A0R3WXL8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5493</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007724">
        <property type="protein sequence ID" value="VDM27088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXL8"/>
    <dbReference type="STRING" id="6205.A0A0R3WXL8"/>
    <dbReference type="WBParaSite" id="TTAC_0000550801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000550801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000550801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000550801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16890" checksum="A6FC5BA6BA40B395" modified="2016-01-20" version="1">MGSTLTYIMTQGCMTQHDMTIQRGGSLNPNINHIFFHHIGGYSIGANHISLSHAFTEKEARELFWQIVCAIDYCHKLGIVHRDLKAENLLIDADFKIKVADFGFCNFFTSEHLLTTHCGSPQYAAPELFKGESYDGPLVDVWVCHLTSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY95</accession>
    <name>A0A0R3WY95_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ku_PK_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5721</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008736">
        <property type="protein sequence ID" value="VDM27526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY95"/>
    <dbReference type="STRING" id="6205.A0A0R3WY95"/>
    <dbReference type="WBParaSite" id="TTAC_0000573501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000573501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000573501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000573501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16009" checksum="C167ED17F65E7FF1" modified="2016-01-20" version="1">MRRASANLSSLGRMSEVWSGLEQAAFMRLLAAQLITCSDAMERDQAFDDFVAKMRSIADHLLLRQTRLRFSLHGEEGSLAPACEQLEAFLSALPLKSDKEEEVKFTPDPSALKSNNAFIVLPYSVYYASLALPAPYYSSPDFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYH4</accession>
    <name>A0A0R3WYH4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009110">
        <property type="protein sequence ID" value="VDM27688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYH4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000581401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000581401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000581401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000581401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="6978" checksum="93E767873BD9D759" modified="2016-01-20" version="1">MAAGGNVRGSAVKALQKEFKELAETPVEGFKVTLVDESNLFVWDVAIFGPPQTPYEGIRGKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYW5</accession>
    <name>A0A0R3WYW5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS5940</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01009854">
        <property type="protein sequence ID" value="VDM28016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WYW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000595501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000595501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000595501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM28016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000595501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29409" checksum="B04886C78791B454" modified="2016-01-20" version="1">MLPMEVVLLKKVAHIDGISRLLEVYDLHGTWNIVMAGNTPAVQDLFDYICKRGYLSECESAFIMYQLVGILLKCHQAGVLHRDLKDENLLIDSDNHEIQLIDFGSGAFLHDGIYRDFDGTRVYSPPEWIKSNGYRGKSAEIWTVGILLFDMINGDIPFMSDNEILSGTVQFRRTLVSHEAMDLIHCCCRQDPRERPTLMEILLHPWMRLFRNTIARLECEPSQYALDESAKYMPSPLAPSITVRSGLCDLANLCIAQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZS8</accession>
    <name>A0A0R3WZS8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HSF_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6305</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZS8"/>
    <dbReference type="STRING" id="6205.A0A0R3WZS8"/>
    <dbReference type="WBParaSite" id="TTAC_0000632001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000632001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000632001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000632001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="619" mass="67886" checksum="6174B24F55CCA233" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X012</accession>
    <name>A0A0R3X012_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6415</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X012"/>
    <dbReference type="STRING" id="6205.A0A0R3X012"/>
    <dbReference type="WBParaSite" id="TTAC_0000643001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000643001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000643001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000643001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8769" checksum="7A14EF3B6E0D1B3F" modified="2016-01-20" version="1">MAANLAKAGLYVDDFNKLRILDPSIAQSTQEFKDECADFINKTEEFQSVTQTVMELFETISAKVEKMKIKVRCWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0F8</accession>
    <name>A0A0R3X0F8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6600</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0F8"/>
    <dbReference type="STRING" id="6205.A0A0R3X0F8"/>
    <dbReference type="WBParaSite" id="TTAC_0000661501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000661501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000661501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248568at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000661501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="16963" checksum="BB130E58EDD70FA3" modified="2016-01-20" version="1">MPTGSADVYGNTVQFSIYDVPGSPEYQSLAAGVYAGIEVAILCFDVTNQASFDGLSAWISRINAGLPSKGVKVLVGLKGDLTRQVQLETARSFATQNGYMYFEASAKTGQKDVNEVFCRSAAKALDIPLPPPPVSATTFLCSHASNPQDTTSAARPSKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Q1</accession>
    <name>A0A0R3X0Q1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PDZ and LIM domain protein Zasp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6713</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020317">
        <property type="protein sequence ID" value="VDM30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0Q1"/>
    <dbReference type="STRING" id="6205.A0A0R3X0Q1"/>
    <dbReference type="WBParaSite" id="TTAC_0000672801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000672801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000672801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000672801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="33726" checksum="FE51DCE603685B07" modified="2016-01-20" version="1">MHAHTHAPSAATSHGKHQVQLPTEKQSDQMASQLLTMKLVREDSSVPWGFRLEGGVDVGLPLNIKSVARGGLAERCGLRGGDYVLRINRTDMRGLTHEQAKMEIIRSSNDFVIMVQRGGAISPIRTTTTTTTIQPMTARVEESVIRGVMDNGQANLKSAFAAPYSPPIGASHNVNPVPFGQAPLPGHSVITRNAEGRTHRILHSEYNSPMGLYSQRNASASFENALSAAGTSSPANVTPKLICDACRGPIAGVMVKVHGSIPMHPECLKCSQCGINLRNVGYFYINGVLYCETHARRAAPPPRQGLQAGVMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0W4</accession>
    <name>A0A0R3X0W4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6786</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020322">
        <property type="protein sequence ID" value="VDM31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0W4"/>
    <dbReference type="WBParaSite" id="TTAC_0000680101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000680101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000680101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000680101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11899" checksum="86C44086EF74ACDB" modified="2016-01-20" version="1">MTTVAARRPYTPHLQQAHPMDYRPYKTLSPPTCHALADPRHGRSEQVEFSKKLFSVPHHNNRKQNNTYQMQTNPIPSPPNHLLSILQASDKVKGQSHNLLLAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1A7</accession>
    <name>A0A0R3X1A7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zf-NOSIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6955</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1A7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1A7"/>
    <dbReference type="WBParaSite" id="TTAC_0000697001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000697001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000697001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="5">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000697001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33393" checksum="73097150C0D71B81" modified="2016-01-20" version="1">MTRHSKNCTANTVYTYHERRKDAKNSGYGTQTVRLGKDSIRAFDCCCLTLQPAQDPVITQDGFIYDRAAILEYILSQKADIKRRQKIYAKQCDRAARDALEKKKAAQDEKARAFMALNTLDTHSKASAQAAESEALASVSKGNCKLTSFVGDYKPGTAASFWTQTPCAGDSLKHENDIPKPDPVVRCPMSGKPLRYKDLITVNFTNLDADDVSSGSCNTGANEIRRVCAVSKDPLTSATRCFVLRPSGAVVTREVVDKIIRKEMIDPISGSKLVESDLIEVRVGCGGFADGRSVLTATRVAPVMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1C2</accession>
    <name>A0A0R3X1C2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020335">
        <property type="protein sequence ID" value="VDM31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1C2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1C2"/>
    <dbReference type="WBParaSite" id="TTAC_0000699101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000699101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000699101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280724at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000699101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42516" checksum="A83AF2B5569ED136" modified="2016-01-20" version="1">MMVLFGSLAMLDDFCPRLSFTVIPTSANSPEDGEGPAVSSKKLNHQSRPSSLILARDGILTGSRSIGSEAINRGNERVNVQSPVLLENEPVELYTSSNGQNFQPPMIETSFGHDGDNLNVVQLSSATDEAVDRKHNCPRFLVLPDRSMSPLRMHDESTSVSQVMISSNSNKAARDEKGGKGTISENQALSLMSVERGISTLEESTTEFQNGDRDLQTTTTMSFSYSYISRTRRRRKVIRRTTELFHMGSNGDLERHFDNGVNSIDKDEYQTEPDLRTMQGGFEQLPVDKRVHRSVSVLPNPQLRSALGSEVTGLPGQRQQCHLPRKASLVARESINLSLQALYTPTKFGSDRAFYFSLDAENTSQVWHEDRFLEARDKAVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1M7</accession>
    <name>A0A0R3X1M7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7112</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1M7"/>
    <dbReference type="WBParaSite" id="TTAC_0000712701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000712701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000712701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6226507at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133129" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14308" checksum="9CC36E7DB9F40631" modified="2016-01-20" version="1">MEKLFSSSLSVTAVIILLVFLAFVEESSALPNAWGHGLLINRRPEVYYDSEVVDRAYILCWMEIQKDILKGRTKRFDPTRLHHPKWIPIADGRAYYLPYSERQKLSLGDSCLLEKGIQIARLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2K4</accession>
    <name>A0A0R3X2K4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Unconventional prefoldin RPB5 interactor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7509</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020378">
        <property type="protein sequence ID" value="VDM31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2K4"/>
    <dbReference type="STRING" id="6205.A0A0R3X2K4"/>
    <dbReference type="WBParaSite" id="TTAC_0000752401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000752401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000752401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000752401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35906" checksum="2D73BEECA7F0E614" modified="2016-01-20" version="1">MDRFDRLLEEQQKAIGQTDDSIGKLQAYVDEYARLKTRLLEVSNCFSRKAIIPFSPRALVPARLIHTNEVLVYLGGCAEHFSEVSTSQSLLIIDERIKRIQNKIQKLKEQKRLLSDRVSYTQRLVRGQQPQSVTEGDEGVEFEIREEFDPVKEKEWQAKHKRRVLTERMRERDCTPTGPSLSPKLGSHDAISSEHPSPPSPDIVVCSSTNQARPVVSYIREWCKASPADVVATIQKGHQEAESKGVLKSTHLRQLPATHEFCEKSGTESEPTSKSSKYPIEPFSQVIERASTSIEAINSTGSNGGHISQFRAKRNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2P0</accession>
    <name>A0A0R3X2P0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPIase cyclophilin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020383">
        <property type="protein sequence ID" value="VDM31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2P0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2P0"/>
    <dbReference type="WBParaSite" id="TTAC_0000757101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000757101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000757101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="131"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000757101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37695" checksum="66097E4C80163584" modified="2016-01-20" version="1">MEIRIVGLVRSWDFHAAQYLAKDLYECFPSVFKQPMFDALYELEWVEFLHNKKRELKGEYWAFNSAVFCFCDGKPIGNFVKLHSWAKEYYFLQNYRPRNFYEMLAYDLYRENLMQRNVRTNSSMSQRNYVSMAITIGGDSCGTLLFELYSDIVPKTCANFMKLCTGELGIIPKNDCENYRMHYLDTIFFRVVPNGWIQGGDTLYGSGDDGCSIYGDNFEAEGLDIPRVTPRSILDENFAIKHDRRGVLSMVNKGRHTNSSQFMIIFQPAPWMDYRYVAFGQLLEGSGTLDAMEKVETRNDRPCREIKIAEIKVLNPKDIHSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X322</accession>
    <name>A0A0R3X322_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7705</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X322"/>
    <dbReference type="STRING" id="6205.A0A0R3X322"/>
    <dbReference type="WBParaSite" id="TTAC_0000772001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000772001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000772001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984207at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000772001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="60904" checksum="87BFD5ACBF1D9D5B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X343</accession>
    <name>A0A0R3X343_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E2F_TDP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7728</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020398">
        <property type="protein sequence ID" value="VDM32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X343"/>
    <dbReference type="STRING" id="6205.A0A0R3X343"/>
    <dbReference type="WBParaSite" id="TTAC_0000774301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000774301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000774301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000774301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32876" checksum="E3952BDE21DF66AB" modified="2016-01-20" version="1">MYPNQGIMFGDFSLEPQGFRDMNRHEKSLGLLTEKFVQLLKEAPDGILDLKLAADFLAVRQKRRIYDITNVLEGIGLIEKRTKNSIQWKGGSAATNGPDIQARLDELQAEVEYLENLEKKVDEHRAKVLQSIRNVQEDLDNEHFSYITHQDLLNVFHDRTLVVIRAPEGTILDAPIPESGMDQSTHSLFAMKRSYKTSPEYQIHLKSPSTAIEALLVNQDDSQGRARIIPPGQPNFDSRRPTANRQEDVSVPNPLFPLSPPPDAQDFTCNLEENETISDLFDVPVPYKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3F3</accession>
    <name>A0A0R3X3F3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7860</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020414">
        <property type="protein sequence ID" value="VDM32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3F3"/>
    <dbReference type="STRING" id="6205.A0A0R3X3F3"/>
    <dbReference type="WBParaSite" id="TTAC_0000787501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000787501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000787501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133140" description="peptidylprolyl isomerase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000787501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8447" checksum="231E6834AED0E0EB" modified="2016-01-20" version="1">MLLTLAVGLVCVAGLNAEKLKEVEVEILGVPCRKFVQKGDYVHVFYVSRLNESKKQFDSNVGDEPIRITVGGGQVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Y4</accession>
    <name>A0A0R3X3Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8072</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020441">
        <property type="protein sequence ID" value="VDM32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000808701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000808701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000808701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133232" evidence="2">
        <location>
            <begin position="28"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000808701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="33752" checksum="49D6429159B826FD" modified="2016-01-20" version="1">MGSWRREKKPLLLLILLPLSQHGDSRAVATDAAAAAAAADTANDEGDDDSTDWTKWEKIGLKDQSHFHAPSATAASLHSLLVSLRRAFEDVRVHTPSHMHMGTSQGVNRNATPHTSHATTTASPPSPHADTLALNAASEASLLHPAHNSPTYQYPRTDCAQTALNGHPDLTGGKCTSESYSNACPIYALSSFLPLPTSHVYYCQKVCYPHRIYLSSHNIVSPHLRPTAPIYFLEPMPPPTPLLTPPHSSSRRLASASWLACCLSPTSCSASFISNTTTSRRPVYTSLLLHLHNINPSTFRSEVAIDAPSRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X475</accession>
    <name>A0A0R3X475_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8182</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020459">
        <property type="protein sequence ID" value="VDM32693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X475"/>
    <dbReference type="STRING" id="6205.A0A0R3X475"/>
    <dbReference type="WBParaSite" id="TTAC_0000819701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000819701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000819701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6614329at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF29">
        <property type="entry name" value="FOLLISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000819701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52257" checksum="2321F315E36A6FA2" modified="2016-01-20" version="1">MCACERTGSALLPCAVSTIGCQRPLIKGPHSPVTNTSALLSLSLSLTLSLSLFLSLFLTLSLSLSQTQDTMALLLILALQALLVFPLSEAGSCFRIRLPNGRCHELIQRNYITRSECCRLGGFYVGGHLTEPQFVRDLLLRRIGIANCHYSCQSALDYFLGFHNESCARVNCPDGFRCEMQNNEAVCACSSICIVEDFESGPVCTTDFRRFRNRCSFLKERCRNLDTLLMEMQCPPAEHVCPYRQNVSHLEEHEHEYPVRICPPHKVCIVRQYSGKASCEDPNWLGRKHIESAFDRVAVSNLDSCANSPYGSPICGTDNTTYNNQCHLRKASIQRGLEIRIAYLGPCRENATCDEVRCQDARMTCVPHVSTGQPVCLDCTDLPPNCNPRVFVRVNPAEIAEMTLFEMSKEAKQNFGDPRWHGDVFTNDWPRVCGSGRKSFPNACFLHVYNCIAKRFVDFVSTGFCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X521</accession>
    <name>A0A0R3X521_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA 3'-5' helicase Q1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8526</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01020523">
        <property type="protein sequence ID" value="VDM33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X521"/>
    <dbReference type="STRING" id="6205.A0A0R3X521"/>
    <dbReference type="WBParaSite" id="TTAC_0000854101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000854101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000854101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="97"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="245"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000854101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65650" checksum="89916EE0D5586A0A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X524</accession>
    <name>A0A0R3X524_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein shisa-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020524">
        <property type="protein sequence ID" value="VDM33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X524"/>
    <dbReference type="WBParaSite" id="TTAC_0000854501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000854501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000854501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276435at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000854501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40707" checksum="0AA04DCC571A7106" modified="2016-01-20" version="1">MAGLWPPSWCPWSSWELCTVEPCTSGVRLPLLKTQRDPTLRSKEALKEYCVNSTNYPITALHWPVDARAGTYRLVTPTQQRRRRCRCHTLKSLIDRFFQKTCKENEVQVDCHTCFPPFSGIYSRSHKGEPLLSCNDLAESRSAAAAASASSSNFYAILGGALGTAAFLVIVFCCVRFFFFSSGVRRRVRRPGGGSRGGGMVGGGLGDSTADPALRRPVNTLPYPHLVCRLCMSGFYPAAEGRRYREFTIIEYFHTVTVYSLNSELPPAYKDVVAMTVILPTATEQCDGSPNQRLLTSLSPPSPPPALPPSSTPPLSVAEESSEGLGGSNESGGSEDPPPPSYQDVISFSPSAADMRQQVLAAAAEAATVREQSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X558</accession>
    <name>A0A0R3X558_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8567</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020534">
        <property type="protein sequence ID" value="VDM33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X558"/>
    <dbReference type="STRING" id="6205.A0A0R3X558"/>
    <dbReference type="WBParaSite" id="TTAC_0000858201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000858201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000858201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235521at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000858201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20791" checksum="AA90DAC4D0D24E20" modified="2016-01-20" version="1">MGDDEEAPSAIYPRAHFYLEEALCEAARTNDLSKARRILMERVDPNWMNGFGLSPLHIACKNGNFEIAKILVCNKAIVDLENAIGVTPLHLAAKNNHLKCAQLLLLSGAAAAKPTWSLCTPREYAPSGSRLRKVLELAEQGISPDPAHVFEMSVEPLVPKFSIPPRSLEREQKSNAPPKDVASVFKTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5D1</accession>
    <name>A0A0R3X5D1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBX domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8654</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020556">
        <property type="protein sequence ID" value="VDM33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5D1"/>
    <dbReference type="STRING" id="6205.A0A0R3X5D1"/>
    <dbReference type="WBParaSite" id="TTAC_0000866901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000866901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000866901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="354"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000866901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69265" checksum="6CEB17CB43A3F608" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5J5</accession>
    <name>A0A0R3X5J5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8728</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020572">
        <property type="protein sequence ID" value="VDM33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X5J5"/>
    <dbReference type="WBParaSite" id="TTAC_0000874301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000874301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000874301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein deubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
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        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="15"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000874301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55798" checksum="3D3129925410501D" modified="2016-01-20" version="1">MSSSRILVRSLRHSAVIKRDRLLCSLVVVLEGLGCSFDYLEQHNLIEAILVAHRTLIDELFLTGRWAVNDQQDVHELYGFFMDRAANTEARQTVLSGREDLLTISRLLPFPPISTNGDTPAATVTAANTSTGVQQFGMSAYFSPHLSSFLSTSFVPSSFHQFIVSQIFCVKCSYRSDLRLVPESCIILFPEKSRKRHTKKMSSKDKESYRCSVETMLSDEFCVAESLAGIHCPRCHMEALRIPEAMINDPSPTVSDRSSIRHFAESLCRNTCCARRWIALPPATTQTTATTKTTKSPLVIYIQRAVWIPLKHIAPDTDDYVLSFIDGGMVSKFTEHIIFSDTLDLAPYLATGCTFHALARRSNVKWGDEKSKKKSLPYALRSVIVHHGNTLHAGHYVAYRCWPGAGTEDASPKNWILSSDRYVDQVPFSRVKECQAYMLFYEPMEEDTPGALQFSTSVEPTPNGEAIEVEEGISLDQITSPAQRIHVLMALVCGEKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5P0</accession>
    <name>A0A0R3X5P0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 tensin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020584">
        <property type="protein sequence ID" value="VDM33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5P0"/>
    <dbReference type="WBParaSite" id="TTAC_0000879601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000879601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000879601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000879601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15334" checksum="871F16D158E23D49" modified="2016-01-20" version="1">MLNEVMAREHIPLSRNYRIDGLVVELKCVPPKESVTETGPEDVLKKTIATTDSWRGPDELEKGCKEVHFCGVVRVNWLDSQEDSVHPNSQFWGHTQFADQQYLRFKVVSLNERVRQLSNFLLLNHRAFKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6G4</accession>
    <name>A0A0R3X6G4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9080</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020675">
        <property type="protein sequence ID" value="VDM33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6G4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6G4"/>
    <dbReference type="WBParaSite" id="TTAC_0000909501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000909501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000909501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267924at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="5">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000909501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38715" checksum="BF305F1ABC41060D" modified="2016-01-20" version="1">MGMGINAQLKLILLRDGVEAPSCENLLDEYIDSDSGTDECPSFELQRDIEMTRKYNVTFPFNGVTTAFHRAIIVDWLTTLQAHMKMDTKGLHMAVWLIDHYPWRAKAKIGNYVLMALAALMVGDRMTSTRSEDECINMRRDLVAHSNNQYSEEQIANNETLLVNLFWCDLPFPTPHTFLKRCIRASNDIADVFDLQRAVALCLYCFDLGLLNCKLAKFSSSMKCSAVMLLLRRLIKGSCVCSRAEINDPSSSCNVHKLWEWTQELGKAMDQECDEELYYVSDIYMKLLREAKCFNNNCEFKFTKGCAPAFEAAFKKHNKQVYLNIPISGILVNTNFIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6J1</accession>
    <name>A0A0R3X6J1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9112</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020683">
        <property type="protein sequence ID" value="VDM33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6J1"/>
    <dbReference type="WBParaSite" id="TTAC_0000912701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000912701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000912701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258370at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000912701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27963" checksum="E534778E7C2D4EF6" modified="2016-01-20" version="1">MGLKISKLPSNQHGWNLQRQKRKDLNSRNKGLGVTYQSSPMGDIEKMKTITTAPLQTPEMKISPTSICSKTSSVELSFPSSSTPSTIPTLHSETDFNNAESIVDSDLVVDSRSHKNRRPQKTSTPSSEKKSSNGAKKPHRMVLTTAPLSSNGLGIEETKRGRFECHFWVPETALSVVTDKNDRRLRSIARSSGCSIELTDDTRLDPFGIPKRKVLIRSVTTYGMVKCRNLIEARFPSFTVHKTPVTKVATPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X830</accession>
    <name>A0A0R3X830_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9690</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020982">
        <property type="protein sequence ID" value="VDM34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X830"/>
    <dbReference type="STRING" id="6205.A0A0R3X830"/>
    <dbReference type="WBParaSite" id="TTAC_0000970501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000970501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000970501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="168"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000970501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33986" checksum="DC40B900A4098D51" modified="2016-01-20" version="1">MLIVYANITSLARLAPSAETLASSNADITPLSNFSAKEQSVDGQFTRESRSRRNSNSSAATFDLASGNPSLLPEVESEAPLSTDEELTSLRADKEHLTTIVADMQRCIAEYERSLRQLAEEKARAEESAKESVIDIISERDQAIEEISTIEKAFGDLHRRFEKSKQIIEGFKSNEEALKRTAQEYQEQLKRQEQRYQALKVHAEQQITKIAEETERTKRANEDEVTRLRAAIKRSELRIHSLESQLEQKVYLFNSPPFFQLLRISIPRPEHLDWTLVRENTELTKICDELLSKYGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X831</accession>
    <name>A0A0R3X831_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020983">
        <property type="protein sequence ID" value="VDM34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X831"/>
    <dbReference type="WBParaSite" id="TTAC_0000970601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000970601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000970601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000970601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8989" checksum="FDC1A79666C1FEAF" modified="2016-01-20" version="1">MSVFLKPFHALKNLYPEERRSLFLLSEFFLFLRRLKDLNKVRLPNSIFGLDQAPAGPHFIPLIIFTGYLLLPLPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X854</accession>
    <name>A0A0R3X854_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9714</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020999">
        <property type="protein sequence ID" value="VDM34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X854"/>
    <dbReference type="WBParaSite" id="TTAC_0000972901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000972901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000972901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10456652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000972901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45270" checksum="0F26CCD79454169C" modified="2016-01-20" version="1">MQISTYLTVQPAPNSSNRTMASQGNRFQCPISVRQNSLTAMAASAKVDEVLAMQKSQVMKSSSPAGTQRGQTQDTTVAQAYQSKVTQNAQLLRTSSVALERTVQNDRNQLKNPISESQNAQTKPMPVFVRTLQVNYCLVDQLCILNDDYKNQPTTDIASVAGNFAPVQSRPQRPLFSNGGAFVPHLTPLYPIHTLSSVACVSNLAVQQQQQQQQTGSSSPQFAVRSAVVCGNCQFVPQYVTIGPNQDIPIDLSIKVSPEKGQRTTSEMQEVYKPSDHRTTGLNGYEEGVAINLAKPKRSKTSETALEPSSSEGNRSVELGTNTESRWKCFLCNLDFEMEWWLQKHYRGHKHVCKLLESVGGSETLQKRIKCREINSETLVNEKTGKLLLHVINRLISFNNNNSNRVAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8H7</accession>
    <name>A0A0R3X8H7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9837</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021094">
        <property type="protein sequence ID" value="VDM34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8H7"/>
    <dbReference type="STRING" id="6205.A0A0R3X8H7"/>
    <dbReference type="WBParaSite" id="TTAC_0000985201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000985201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000985201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000985201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18371" checksum="2735BE031732448B" modified="2016-01-20" version="1">MNSLKPLNKNASAQIELTKLVSKRWCVDFNSRSRTGLTTNGPCEQSIQPVGFSDRTFPHSETREQDPQLKVKRSWDIALGPLRQIPMNLFIMWMTGNSISIFPIIMVYMMFTRPIQVLFSMQTTLQMIEGEQAPIQCLVFILGNLLMVAMAIYKCHNMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J9</accession>
    <name>A0A0R3X8J9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ion_trans_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9859</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021114">
        <property type="protein sequence ID" value="VDM34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8J9"/>
    <dbReference type="STRING" id="6205.A0A0R3X8J9"/>
    <dbReference type="WBParaSite" id="TTAC_0000987401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000987401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000987401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport N-terminal" evidence="3">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000987401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="605" mass="67650" checksum="4F39F3EB27633A7E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8M3</accession>
    <name>A0A0R3X8M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial coenzyme A transporter SLC25A42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9883</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021129">
        <property type="protein sequence ID" value="VDM34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8M3"/>
    <dbReference type="STRING" id="6205.A0A0R3X8M3"/>
    <dbReference type="WBParaSite" id="TTAC_0000989801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000989801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000989801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="223"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000989801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36517" checksum="56BFE29CB6293131" modified="2016-01-20" version="1">MVKGLLRGSTPSFADFIIGGLAGCCAKTAIAPLDRAKINFQSTSFLTKLNVAASEMCFNVKALFNFLKHSYLTAGVRSLWRGNSATLTRIFPYAAVQYGVHERAKHYLGISDLPHHCLSKSQVQLRRFLAGCIAGTVSVSFTYPLDLVRARMAVTERVKYANLVDVVRLTCREENLRSLYHGFTPALFGILPYSGIAFFTFETLKEWRIKKRLTSDNRSPQSLRPIENLSCGALAGVLGQTASYPLDIVRRRMQTGSVTGHPEYTRSIMGTLRIVYRQEGLFHGLYKGVTMNWIKGPIAAGISFTVFHQLQHFYTLWQNQRGLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X963</accession>
    <name>A0A0R3X963_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UmuC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021290">
        <property type="protein sequence ID" value="VDM35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X963"/>
    <dbReference type="STRING" id="6205.A0A0R3X963"/>
    <dbReference type="WBParaSite" id="TTAC_0001008801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001008801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001008801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000002">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="45"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001008801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24775" checksum="AA215FBB3FB6011B" modified="2016-01-20" version="1">MRRGAILKEQVERKAISNLVTFTFSLQADKLLRGYSAERRFDRCIVHIDMDAFYAAVEMRDDPSLRLRPLAVGSQSMLSTSNYLARRFGVRAAMPGFLGIKLCPQLTIVPPDFVKYTEVSRAVRSILGGPTGLVVMSLDEVYLNISKHLKERIDWPPNERTYWPHDELATCLLCGMLIRPGPRLFGTSAEEAVREMRFRVFCATRLTCSAGQFKLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9D7</accession>
    <name>A0A0R3X9D7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10147</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01021357">
        <property type="protein sequence ID" value="VDM35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9D7"/>
    <dbReference type="STRING" id="6205.A0A0R3X9D7"/>
    <dbReference type="WBParaSite" id="TTAC_0001016201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001016201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001016201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001016201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11631" checksum="B6427552D8066DAF" modified="2016-01-20" version="1">MEWRYHLSHEVFVRSLDKEKRARLLQFITGTCHIPLGGFGELMGSNGRQLFCIEKTGTDAWLPRSHTCFNRLDLPPYTSYDQLREKLLLAIEETEGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9K2</accession>
    <name>A0A0R3X9K2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10212</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021431">
        <property type="protein sequence ID" value="VDM35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9K2"/>
    <dbReference type="STRING" id="6205.A0A0R3X9K2"/>
    <dbReference type="WBParaSite" id="TTAC_0001022701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001022701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001022701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000031">
        <property type="entry name" value="cyclin-L1-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="164"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001022701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67445" checksum="3920536295489B52" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9T5</accession>
    <name>A0A0R3X9T5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021516">
        <property type="protein sequence ID" value="VDM35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9T5"/>
    <dbReference type="STRING" id="6205.A0A0R3X9T5"/>
    <dbReference type="WBParaSite" id="TTAC_0001031001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001031001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001031001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001031001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6300" checksum="D3BD00CE845E1A0F" modified="2016-01-20" version="1">MSMVPYVLPSRVLHIRGLPADTSETEIVKLAMPFGPIANFVLTKKTGQVRIRVFVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA35</accession>
    <name>A0A0R3XA35_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS10394</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021647">
        <property type="protein sequence ID" value="VDM35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA35"/>
    <dbReference type="STRING" id="6205.A0A0R3XA35"/>
    <dbReference type="WBParaSite" id="TTAC_0001041201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001041201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001041201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
    <sequence length="773" mass="89139" checksum="BFFE8985ABDE7104" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB68</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0001079501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46373" checksum="75F98812DE8A15D0" modified="2016-01-20" version="1">MSYTDRFGMAFKVALRRSPQELAERCQQCRKIISAAKEKQEGEARKNASVLLEQIEQEEEERANKEAMQARKRERKRNKRKAKQEAAAAAEAAKEKAAAAAAAAAAVSEVVPKKTVSNKLDEEQSSVKQTEIIPKVEESTSIVQPGQNKLSPSSNNAIESLSVNTEQQHQHKFEPSSSKKKNKHQTPPSQTVEQSVQKEPDTSKSMPSQSNFSETKREKNRSKKQPQQQPQQSQRSKPTASQQTLESAASPTASIAAAEADVGDSVLWDTSAFDHSSGSTAGNDWLVAQPGSSNRGHRAPTSMVNQTDNFSGSDWKTSGPSGSGSSAKRKIAISVSKHDIGKIIGQGGAVVSALRNMSGIQIDIESARGDEVTERMVYLKGPGEIVHRTYQMIQDLLSGALAGNEVIARAKTNTKMGANSSFSTPSNGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC70</accession>
    <name>A0A0R3XC70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM36109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC70"/>
    <dbReference type="WBParaSite" id="TTAC_0001114701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001114701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001114701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247241at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133373" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001114701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10136" checksum="8E780E07AA4E291F" modified="2016-01-20" version="1">MNSIFLGVLCLLATAAGQRPAMDTQPMDVPTNWQQDAFFRQQRANLATSKQALIAMINELRETIFRQQLLLTQYFRDQAAQPVQRPNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCI7</accession>
    <name>A0A0R3XCI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor SOX-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11247</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023377">
        <property type="protein sequence ID" value="VDM36227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCI7"/>
    <dbReference type="STRING" id="6205.A0A0R3XCI7"/>
    <dbReference type="WBParaSite" id="TTAC_0001126401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001126401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001126401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287265at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001126401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30050" checksum="6C373A8694243EC9" modified="2016-01-20" version="1">MKKDGIQTRNRKVSQKSKKCRSSGGFSELEELSLDYLIKPTLSHLTAASHLAAAAGYHPHKMADYMSSYLDGVSSAYTLSSASSTGYPPVESAAAVASAAMVAMGGSQSSPYAMSQPTGFSLAYPNHSHPHQLQHQTSYRTPNESATTTSAYFSDSGFHQTGGVSGAYSIFDGHQFTKTPFPRPFFQGQPDTSTGGEEPTAEVAQYQTRFMAERTGYEEEVRMYPNTTSTPVFSQESQVATAAPATPSSNITNYISATRLGKQEADVTPSNENATAPPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCJ0</accession>
    <name>A0A0R3XCJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11250</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023381">
        <property type="protein sequence ID" value="VDM36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0001126701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001126701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001126701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001126701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="DEA26D433DEC1CD9" modified="2016-01-20" version="1">MVCTWEELQLALSLPPLAVAVCGVRVGGISFFCFLPLNLLTMLQPMKELWARLRLLCLEAVSRVPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCM0</accession>
    <name>A0A0R3XCM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023478">
        <property type="protein sequence ID" value="VDM36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCM0"/>
    <dbReference type="WBParaSite" id="TTAC_0001129701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001129701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001129701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001129701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="6329" checksum="FDB2A4DD9B27F1B6" modified="2016-01-20" version="1">EEQEEQEQEEQEQEQEEQEEQEEEEQEEQEEEQEEQEQEEEEQEQEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCS2</accession>
    <name>A0A0R3XCS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11332</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023677">
        <property type="protein sequence ID" value="VDM36312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XCS2"/>
    <dbReference type="WBParaSite" id="TTAC_0001134901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001134901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001134901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979034at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF531">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001134901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29199" checksum="B3FD5C50660FCC03" modified="2016-01-20" version="1">MCLLHLSSLLYEREKEKCWPYWPRKQKGKAIDGEGDGLSSELCSATYGNFAVTLQSTETGLCYIRRVLVIRNTAVENGVPRRVIQLQMTRWDDFKVPRKDDFYFFLKKYWDDFKAMNKQSTDSVLVHCSAGVGRTGTFIAIDMLVQYLQRVMGMEEKKSVGEAMEAEDDISWHESVYANLTESGKPIPLYNRAALDRSTSTLNIYHTVLWLRSQRLKSVQQDWGEPXXXIFIYDFLSYYIQCLADEAGKCLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD03</accession>
    <name>A0A0R3XD03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteoglycan 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11412</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024071">
        <property type="protein sequence ID" value="VDM36409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001143001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001143001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001143001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9908153at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001143001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="29179" checksum="AF4DEAB45E21FA5C" modified="2016-01-20" version="1">MTTVTQAPIVNATIDGINTTNVKEGSANAAYTMGPTSTKDETTTEEIPTDLGELSSEPPVTEEIPTDLGELPSEPPATEEIPTDLGELPSEPPATEEIPTDLGELPSEPPATEEIPTDLGELPSEPPATEEIPTDLGELPSEPPATEEVPTDLGELPSEPPATEEIPTDXXXXLQPPRRSQPISETTEEVPTDIGKLPSEPPATEEIPTDIGELPSEPPATEEVPTDIGKLPSEPPATEEVPTDIGELPSEPPATEEVPTDIGELPSEPPATEEVPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDH7</accession>
    <name>A0A0R3XDH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11587</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025334">
        <property type="protein sequence ID" value="VDM37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDH7"/>
    <dbReference type="WBParaSite" id="TTAC_0001160401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001160401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001160401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001160401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11818" checksum="18039FDECBB2F118" modified="2016-01-20" version="1">MVFHGGGGGGGGGGGSRRARDADVAAMNRYACAPQAHGSALLLAVLATYHINLSPPAILAETMAPYSTTRPYIAISPNHGYGREAWRLYATHCCQTSRNSLLVEIAVKCDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE89</accession>
    <name>A0A158RE89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6884</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020329">
        <property type="protein sequence ID" value="VDM31164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE89"/>
    <dbReference type="STRING" id="6205.A0A158RE89"/>
    <dbReference type="WBParaSite" id="TTAC_0000689901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000689901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000689901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000689901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20451" checksum="8ACD8A0825FF647C" modified="2016-06-08" version="1">MNLGKSLLIGANASIEKPRIVQPLKSEKVISGQPVLFVCMVEGNPSPQVQWTISGISVFSSPQFGEVIAMPRGSVLRIANALPTLNGSAVVCIAENALGHAEATARLFVYQNEEMAPPGFPRFLNVFSVIVAKKNDKVELECRTQGDPSPLIRWFKDSTPIDHTNTRFLVTPAEIWRRSHTRRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF36</accession>
    <name>A0A158RF36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020568">
        <property type="protein sequence ID" value="VDM33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RF36"/>
    <dbReference type="WBParaSite" id="TTAC_0000873101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000873101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000873101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000873101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17645" checksum="5BD9DB34AB25FE5A" modified="2016-06-08" version="1">MDGRVQCIGMGGSDGVENYKCVSNEVVQCQWKFFSLERQDLRXXXXLIQACVAWALYALISNLTSSGTSGSERNWQFWLKVFVVLVGMFSVGVFAYVQARYCCDICQRWRRLNRVCVVREPSKERLAKMRMEQRLPTSRFCVVNEVETFTAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EAI7</accession>
    <name>A0A3P7EAI7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000423">
        <property type="protein sequence ID" value="VDM18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EAI7"/>
    <dbReference type="OrthoDB" id="6277039at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="184"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="837" mass="92665" checksum="A2BB4CAAB03637C2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F0G6</accession>
    <name>A0A3P7F0G6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002205">
        <property type="protein sequence ID" value="VDM22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F0G6"/>
    <dbReference type="OrthoDB" id="6278579at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="395" mass="42617" checksum="613CF5AF0B0A68D1" modified="2019-02-13" version="1">MPYKVPSRCTMECLIISDILCQFFLPMFDSKPHYPTSHLYYQSTRKCSTFYPPPLVKARTMFHASQESAQMARNQVTHLSEEVAALQIQLNAVNTALKAAVADAASSVTCATTTLHRIPAPLGSVGGARNLRSRLARKSAAGETEHQMPVEPMTSEVESEVDHLPPLENARSPTRLHRVSSLSSPRRPLLIPSASIGGLPFLPSPLPINFCFSGHLDVPGKPGRRKKLVWDQRFAKLTFSRFLVWDTIKSSDSAQSSAPLDSLASPLETAALGSTVSATSGRKASRPGPNLLLDLPLNAILHVRSVTSCDVLHAPAEDLPRIFQIIFDQCEAGGASSGGTRQTSEVRVSSPDSSPHCPTSPPPKSSPSTGLLGWLICSVLLMGYSVLLIAYLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F5U2</accession>
    <name>A0A3P7F5U2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003398">
        <property type="protein sequence ID" value="VDM23897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F5U2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="224" mass="23540" checksum="7C9C4C20A994C807" modified="2019-02-13" version="1">MAASGDSLNMENDSFLDLLINLQGARMNDQRADFPGLIRTTSMPNSPSTNAASNTDTTVAVSTTTTVHRNTSSSTVGETTSLMTGAGGGVNLAARMRSASDGLAEVDQTPSVADELAPGDDFFDMIFRLQQKTRINDQRSVLPAALQTQNHHHRTNYRNRHQDCNSSNNNNEDATTAGCHDGGGGGVTPHRLLRVLSVPGGKRRRRGGGGTGNSGNSSSKAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFS9</accession>
    <name>A0A3P7FFS9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM63 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01008936">
        <property type="protein sequence ID" value="VDM27619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFS9"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140934">
        <property type="term" value="F:histone deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="67" mass="7675" checksum="7F29A4671318CB02" modified="2019-02-13" version="1">MTIFDLFRIPLYHGWVADPQDRDLIEALRNQTYNQVVEMIIDYKSSSDPACVEKGNVPPLCSEKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GAA2</accession>
    <name>A0A3P7GAA2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAF6 C-terminal HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01025328">
        <property type="protein sequence ID" value="VDM37187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GAA2"/>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018337624" description="TAF6 C-terminal HEAT repeat domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="7">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM37187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="112" mass="12585" checksum="4B72CDE1CD9B23D3" modified="2019-02-13" version="1">MNAINSNLAILIYLVRLTKALVDNPNVSLKAYLQNLVPGIITCSLCRQVCAKPITDNHWALRDFAAKQLVAICNKSGVAYRIVYYKVIHFCSSEVFGFKVVILLQFFLASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GG74</accession>
    <name>A0A3P7GG74_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the metastasis-associated protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001814">
        <property type="protein sequence ID" value="VDM21768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GG74"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="METASTASIS ASSOCIATED 1-LIKE, ISOFORM D"/>
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    </dbReference>
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        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM21768.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65674" checksum="758A3F903E52AF3C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GGY6</accession>
    <name>A0A3P7GGY6_HYDTA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001961">
        <property type="protein sequence ID" value="VDM22008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8251209at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="280" mass="32187" checksum="554AAAC1900884FB" modified="2019-02-13" version="1">MPSNLAYSLIGILQKIVEVVFYDTWSFALKPKALCFVDNRMHRELLSLVSTIDLTRWNLHSSEENPFDFNARCYRLLLYTMARLLFAQGYHSSIVDHLAISDNNLVSIFCSDDVLLFRMLLTLLLMENTAIKDGFLEVIGFDHYCLIDWLVSPETDCLAYLLAYTKRLAAASTDDAEEKRRWYPPACWLELHREGVREVMECLAKSLQTLHIDGSLPFAPDLLITHIHMAVKVLSSMTQEQQNIEVDASRLGERWCTLGKSGGTHHSYTTKLQYTLQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GHF8</accession>
    <name>A0A3P7GHF8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002090">
        <property type="protein sequence ID" value="VDM22188.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2130750at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="189" mass="20891" checksum="914DAAE50EBE29BE" modified="2019-02-13" version="1">MTAEKTRLSEELKQALEHTIELKEQVDAALGADQMVSVLTQKNLELEEAVEKLTEERNDLESLCEMNDELLEGERERQLELAEQVDLARGQMRELVRQLEASRETVADYEQTISKFREVVTQLQTQNTQLGQALADARRSASSASLAAMAADQSATAAEASALMLGNPAGKQMEAQTVAKVMPPFSRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GPX1</accession>
    <name>A0A3P7GPX1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003639">
        <property type="protein sequence ID" value="VDM24152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11445" checksum="801AEAAED51B82CA" modified="2019-02-13" version="1">MIVEDIVDSGNTMNRLHAYLNTLEAKSVTDVCLLVKRTPRSSGYRPCFAGFEIPDDFVVGYALDYNEYFRDLHHICVLNKAGLECFAVPEGSDNHAQEAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HKX0</accession>
    <name>A0A3P7HKX0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021563">
        <property type="protein sequence ID" value="VDM35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HKX0"/>
    <dbReference type="OrthoDB" id="6235335at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="259" mass="29187" checksum="2BB07AA1710B5A3A" modified="2019-02-13" version="1">MAGLCVHMLVNAPYKWNPLRTNILGATSLDLAMSNHGAYLPVVWPLAMASTHVYKDASSNPSLASLLLRPPITPLSPSLIVGICEGNVIDTEFATNKITLLFELIHCTPNLLMESWTEPEINRCTQCLAIGDTEEAICLKDQNKAFDFPVRYSCWLWHRYHATCEVPGQLNPLSLLSCCRVVIRRAIMNNLANSDLAMDYAKALKSLTLPPRMLAFLSFQEMWPVVNAKHKFRFRQRQYGALPLRHPLQPVYDVHDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHL1</accession>
    <name>A0A0R3WHL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS35</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000002">
        <property type="protein sequence ID" value="VDM15651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WHL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000003401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000003401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000003401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="333"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000003401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="644" mass="72112" checksum="BBC24DABEC928BEB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHN3</accession>
    <name>A0A0R3WHN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prohormone-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS59</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000004">
        <property type="protein sequence ID" value="VDM15770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000005801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000005801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000005801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6239681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053103">
        <property type="entry name" value="IDLSRF-like_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967:SF0">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM15770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000005801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23675" checksum="2689A27DA208472E" modified="2016-01-20" version="1">MQQCRCNNSSSPELETIMPSHRTTQRVLVIGMAFCLLSNGICSTIPAESNEKDAKKKIANECPESSPWPCREPGFCLSFDFICDGELDCPDGYDEDREMCTAKQRPPVEYLFRFIQRYQDWLIPTFLGEGTSLELAKKLVESPTIEDYARSAHLTEKQLVNLNSLIEGVVQRKEMYMVLLGMPLGAWSELFYLFNRIVSSGFVSTADSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIM8</accession>
    <name>A0A0R3WIM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS464</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000041">
        <property type="protein sequence ID" value="VDM16489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000046301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000046301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000046301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10307844at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000046301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="43982" checksum="BAC2BA689E4AE0A1" modified="2016-01-20" version="1">MTLIRIPCITSTRRDLGHFHPERREMGSPSSDGDSYVFVRSNSRGVRRAVSEPPSFHYEACRESDFAGFLSVGSAECATACYIGDVRTPNPTTLKGITHGLSSISICQSDNCVNEDAIVESTSTSMNSGSLAEPVNVGPVDGNEKSQDSVSGDFISSTSSTFTHSDSMNGTTAMESLDTVEESDDTLSEKYANSNSTTSLSDSLDVPPPVMLGSLDDARAMEHLHSIKESEDSLSESSEDEISSFSSETDSLEERRQDRPVSSQTVPLPTIIDAATKTTKPALLDDLFDLVDDPLVILKLDSQARVPYLNWFAFFCDFWPKVMNKFESDFSSLPSCLQSQYHRFFKPHEGPSYETYIIMYQLLSLRLNELFHVDTLNKNLYDLLCYAYYATYHKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ5</accession>
    <name>A0A0R3WJJ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase E3D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS845</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000111">
        <property type="protein sequence ID" value="VDM17069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJJ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000084401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280644at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37774" checksum="F0B33E863CE26382" modified="2016-01-20" version="1">MMLLASPWGRIPTTPIDSRHESLKVTCMESSGNLSKAVRMNRRSFRRKSIAYPTSIVIEVTNQEEEKDKSKYTEERTSEKQVIRQKRKVKADVSLYIDIHNPPEDVRQSDTTLRNDSTVLKVLEPFYLSKSASEPRQQRIENNFNENEMACLFKGGFQVKALELLSLESSISEHERGEESSLGLATIQVTASLSAEISPLLKLIAPILAKHLKCPVEVLEKAGRKKEDIDQILSRLTALLSHKTILCDFSGIPTQYSSQSDKQYSSSLPSYPPPPPESYMHRHTSDSNPSFLSSEAPVPSIPERTVPKTTTYDFYYHLQPPPPPPTAEPRLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJZ0</accession>
    <name>A0A0R3WJZ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1015</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000156">
        <property type="protein sequence ID" value="VDM17312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJZ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WJZ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000101401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000101401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000101401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67933at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000101401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60064" checksum="AEFA9885D72AD0EE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK03</accession>
    <name>A0A0R3WK03_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1030</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000160">
        <property type="protein sequence ID" value="VDM17334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK03"/>
    <dbReference type="STRING" id="6205.A0A0R3WK03"/>
    <dbReference type="WBParaSite" id="TTAC_0000102901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000102901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000102901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000102901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35630" checksum="08F300FA54EFF361" modified="2016-01-20" version="1">MIWEKRNYGIQVDAINWKNYDFEHAKSADLLVSVGGDGTFLSTALRITEKDKPIIGINSNPQSSEGSLCLPRYWYKKIPVIVDRLVNGQFNRRFRHRIRLLVSTSPTQLVSLDTITPRIVESHALHSYLSDEDSVGEPAVPNLSPDYLLPVRALNDVFISACLSARVSRYEISVDEEMAVPQKSSGLLVCTGTGSSSWYRSLHQVDVHLVSRLLYLASASHSDNAAAAEVAERFNRDLVFPSDSTLMAYSVRDLITNHVFKFGSPRGFAKKLRVVSRMDDAYLFVDGWLALPFDNGASVELSIHSDDALCVIDFDDSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKB4</accession>
    <name>A0A0R3WKB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Programmed cell death protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1152</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDCD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000197">
        <property type="protein sequence ID" value="VDM17548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKB4"/>
    <dbReference type="STRING" id="6205.A0A0R3WKB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000115101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000115101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000115101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414546at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039778">
        <property type="entry name" value="PDCD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626">
        <property type="entry name" value="PROGRAMMED CELL DEATH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="151"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="376"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000115101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55235" checksum="5EAEA0D119C3E80E" modified="2016-01-20" version="1">MSGTKQLQEGSCVDASGEESAGEMTWEKPAFDNEAPNLKCQNPRLLRKRRTHYNSISHAGVNGLTLASGNSTSSGDGLLVTTRGPYGKNSRKSRNGFRQTSKKASDKDVWIRVGDELDELELDHDDPDYESEEEVSPVVIESVKAVLSDEDFEEFFSTLVHEYYDHCKVEEVIDGLKDVAMTPLQRRRLPVLAINLALQHKMGHCELTSELLSAMCGKVISMSGMQQGFQLLLDDMPDIVIDVPKAPEYVGRFIARAVADDILPPKFVQQCKEVNAAMPPAGTSPVVADTAHPPVRIASRRDSASISESVGANTRSSSGVSSGCNSSAHATSSGDAPANYALQAINKAEALLTLSHAYRHLDIVWGIPPNERVTTMLMKQIYCILLEYLRTGSFEDALSSLQELDSPHFHHELVYQAILLVLAREADDHVSDRMLELLDTLCRSVVISFDQLTMGVKRVYAELPELHQDLPIVYVLLERFLRAAVAKGFLPQKLANEMPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKM3</accession>
    <name>A0A0R3WKM3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1268</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000240">
        <property type="protein sequence ID" value="VDM17719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKM3"/>
    <dbReference type="STRING" id="6205.A0A0R3WKM3"/>
    <dbReference type="WBParaSite" id="TTAC_0000126701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000126701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000126701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000126701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17876" checksum="C889BF5476CB3CB1" modified="2016-01-20" version="1">MIIVLSDWVGPERLAKSLAIMMVNLGLLYVPAQAVIGYLNDLTGSYVWSMRLCGLWLLVGGLVFLLEFPIRQIFRLRNETHQSHRRRQRQQHNNGMSSMRSPWCQHFNGDQNAIEVPAALLTISSSPQLPMVPSIAKAGLSDSTIPFICSPLEEEGEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLA3</accession>
    <name>A0A0R3WLA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPSF_A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1528</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000359">
        <property type="protein sequence ID" value="VDM18155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLA3"/>
    <dbReference type="STRING" id="6205.A0A0R3WLA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000154101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000154101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000154101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000154101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20200" checksum="1D2ED9BC562C7549" modified="2016-01-20" version="1">MTESPPSILNDFSFYKEIAFFPTVGQGTVHSLTHIPSQSSIDRGEERCCRKHDILVASLLPGGETSSSARCCNLYSFESGGKCLTTSTKSFDFMYLPVADIVCIKAFYDEQSRKYVVSMGLVKEEGSCFFNIYAAQRLNDLPEQCICLSELVHFPVQLHVTNNEGTAMGVSVVNVGVVAAAAGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLG0</accession>
    <name>A0A0R3WLG0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fused homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1585</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000389">
        <property type="protein sequence ID" value="VDM18248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WLG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000159801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000159801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000159801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14002">
        <property type="entry name" value="STKc_STK36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000292">
        <property type="entry name" value="Serine/threonine-protein kinase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM18248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000159801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1419" mass="156452" checksum="13C54AFC52B4E914" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLQ8</accession>
    <name>A0A0R3WLQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000445">
        <property type="protein sequence ID" value="VDM18391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000169601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000169601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000169601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000169601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9113" checksum="A75746EA129155EB" modified="2016-01-20" version="1">MASLSKESHAYQPTLSPFFTEVWERNYEKKFNLIAVKSLALPWAVKSLVHSLASIKNSKRRDLELVPVASASAAAVAAASAVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLY7</accession>
    <name>A0A0R3WLY7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000495">
        <property type="protein sequence ID" value="VDM18502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLY7"/>
    <dbReference type="WBParaSite" id="TTAC_0000177501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000177501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000177501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000177501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8544" checksum="CCC284B7B6401F92" modified="2016-01-20" version="1">MGEVCGWGVILEAIYRRLKRAVCTVNSLMRPLGALALPDESGVGVDRNSGWAPAYRTRIRSGGRRRSDESVRWRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMI8</accession>
    <name>A0A0R3WMI8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1963</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000642">
        <property type="protein sequence ID" value="VDM18703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMI8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMI8"/>
    <dbReference type="WBParaSite" id="TTAC_0000197601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000197601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000197601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="392"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="394"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM18703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000197601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="67918" checksum="99BB29567637C72E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMR4</accession>
    <name>A0A0R3WMR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2039</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000703">
        <property type="protein sequence ID" value="VDM18779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMR4"/>
    <dbReference type="STRING" id="6205.A0A0R3WMR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000205201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000205201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000205201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
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    </dbReference>
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        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="348"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000205201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61297" checksum="2A5AD29E782C9130" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNB9</accession>
    <name>A0A0R3WNB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000888">
        <property type="protein sequence ID" value="VDM19359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000225701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000225701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000225701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000225701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9337" checksum="1FF36D450214586F" modified="2016-01-20" version="1">MEDRRIRRPTRTCIRAQGGHPRTHARSPSATRLADSPHTLQAACACSVQTRTRRYPSLLPPASFPSPSSSSSCACNPRAYAGTTNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP99</accession>
    <name>A0A0R3WP99_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2574</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001232">
        <property type="protein sequence ID" value="VDM20525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP99"/>
    <dbReference type="STRING" id="6205.A0A0R3WP99"/>
    <dbReference type="WBParaSite" id="TTAC_0000258901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000258901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000258901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10657058at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000258901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="36766" checksum="F45BB16187700328" modified="2016-01-20" version="1">MPTIRPSPLSLLHGDGSDLITSTMDDLFDCGAFDDKPQDSDVRDGKEKILSSLTLTNLEKVECMQVGKELPSNLRGYYSPPTSFIIPYSNSRSSATATTSSLSPQPLRRHLCDFASVILYVLTELLKVTSSARGCVNTNTLLPVAKTDSRPPRGGLLDEDHQWSLPGGQPFQHVKPTVLSNDMLLIHSVCGRHLLKEVTQRLVSVDSPNSGELSSQVFDSPKLLRPSNSLSSVRRESALGSPVLSRRPSSHLGQSPHHRSSKSALSALLDSWFADVIACPSVSHYNTICPFTTDQIVSLQPPSLLAGDEYHMQLGEGVAIINSSVRPFISLPLNLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPT7</accession>
    <name>A0A0R3WPT7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TF_AP-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2762</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001482">
        <property type="protein sequence ID" value="VDM21100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPT7"/>
    <dbReference type="STRING" id="6205.A0A0R3WPT7"/>
    <dbReference type="WBParaSite" id="TTAC_0000277701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000277701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000277701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279381at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000277701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41008" checksum="04352EC6B0CCF5F3" modified="2016-01-20" version="1">MSGFHPVISLHTSSKLDNKIKSEVVVDMLNLAGFRLPPRLAKEETKRGPSSPKKLHEKAAEGHVSDDLADRSSLLEHDYNRLPIHNPEQLRYNLTNAEKKKHRAYAARSQSPPDMKTILDAPTTDDTLMLVTTINEWYRASLGRFERIYPQHGSQSASMMSMIDSAGGDGPSMYSGQLGTPRYYDALLYQFVQRFGTPLVEGAPTVFESEEGVKEASARSPSKQGGHNFRVLSKALGISIKGLLFVTKLAEQHMPSISSALDTCRTLEIGKNRGSKASPLPPSPPINVPKRVMEPHQTSARSVGRLPRVSELQPSTLPNIRPSSLKGRCISITCQSARQSCQWSSQVATTSTRSQAATRLLVKPKSRFSTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ60</accession>
    <name>A0A0R3WQ60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4455 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2884</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001634">
        <property type="protein sequence ID" value="VDM21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ60"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ60"/>
    <dbReference type="WBParaSite" id="TTAC_0000290001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000290001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000290001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265861at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000290001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="762" mass="87442" checksum="551CB28D6F1E7631" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQE6</accession>
    <name>A0A0R3WQE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2971</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001754">
        <property type="protein sequence ID" value="VDM21647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQE6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQE6"/>
    <dbReference type="WBParaSite" id="TTAC_0000298601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000298601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000298601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5965479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000298601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65206" checksum="DBCE2A5E5B2D4D1D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQF8</accession>
    <name>A0A0R3WQF8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aha1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2983</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001768">
        <property type="protein sequence ID" value="VDM21678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQF8"/>
    <dbReference type="STRING" id="6205.A0A0R3WQF8"/>
    <dbReference type="WBParaSite" id="TTAC_0000299801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000299801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000299801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000299801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30509" checksum="CAA33F53334A737B" modified="2016-01-20" version="1">MAKWGEGDPRWIVEERADAKNVNNWHWIEKKATQWSIDKIKSLLTGFIVDTDKCEKFVIAHCLDYLEVVKVSKCEGEAAANNRKAKLIIFYEWVIEMEWKGCKKGGESPVKAYGTVVVNNLSEEYSPEEWDFEVSCQSTKPEANELKEFLRTEGAIYLRKQLEIYVTDLKHEYGKDLILPTKDKPDIPNSIMKQPPNTKPLVDTIRSSDIASSKMHAVAGEVDAQSTVQISLQEDFICTPEDLYKVFVTEEVRIVTYLHVFLLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS05</accession>
    <name>A0A0R3WS05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4042 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3530</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002592">
        <property type="protein sequence ID" value="VDM22817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS05"/>
    <dbReference type="STRING" id="6205.A0A0R3WS05"/>
    <dbReference type="WBParaSite" id="TTAC_0000354501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000354501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000354501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66533at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13251">
        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4042" evidence="1">
        <location>
            <begin position="309"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000354501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55163" checksum="0D92B382BE6A04D1" modified="2016-01-20" version="1">MDKPIELENWSTLCSLFTGSAPDFSILEAQLDAGRFPSLTRSSCLQILSEDELQRSKEIFNKLALNLSTSHAHGRVSSIRFCRDVGNMVKGNVVLFEQITFKTLLDSLLTVKVVQSNAELRQNLSAGLASLLYLCPINYRIASGTTGTTAESSKVAVGSSNPDFLDFQSGESCLDLLTSLLEMAKEDTKTELSCFHALVQLLCHRKLFHPTRLIPAKLDRLVRVTQVIWPVAFCISNRQSRWEEGSAPISSSSSICPSSSGGDVSDAGGTENCAVRELKKSRLLATFCLRRLLTSKRICRETWTSTGIRSFQSDFLEAVCRERDARLRELFIVMLGVVLDNLALRFIVAEEPSNWQPTTFIPYSLRVAGELRALHRSLIWALRTERSFRHQLALLKVFAVLITVTPYYRLHSGLLSNVITNLNSFHNQTHCISPILPVWNAILAKTPTPEVQRLLTSPTPTLRVLSLCDTSSMSPNPCWLVLVGLLKTIKSYLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT73</accession>
    <name>A0A0R3WT73_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3949</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003342">
        <property type="protein sequence ID" value="VDM23829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT73"/>
    <dbReference type="STRING" id="6205.A0A0R3WT73"/>
    <dbReference type="WBParaSite" id="TTAC_0000396301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000396301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000396301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000396301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14962" checksum="4FAAA89049552755" modified="2016-01-20" version="1">MWDVKLCMSEHDFVANPCLSIASTRDLLDLKRTLEEREMALAAAPPPLVSGLKVKVAMEALQPHPSPPPPIPQKPQHQQPQHIVAAEQPIWPVSVSRERPQSLLLMQNRLPDRNGRPEGVDQSHLRVDRDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTA4</accession>
    <name>A0A0R3WTA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3979</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003407">
        <property type="protein sequence ID" value="VDM23909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000399401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000399401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000399401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265585at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000399401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="50666" checksum="CACC6EA0DDDAEB29" modified="2016-01-20" version="1">MQETEIPSAGKNDPNPWQCRRSSTFSGSTQGSRLTGVFDVGADDRSLRGALPSTASLASLDDVSTASPPLTPHTPSGFEVSAVGGATTGFQRWCNCVRSATTTAQLHLLLRALERSVRKANRGGRGVPAAIGSYATRFRLPEVRCTACRGPPDEASVSGGSGTVVTAFCLCGGCACPFHQDCLLNSLSRQSSRSLTSIRTNAYRGARTPDAAPITALSCLYSLMPCHINTTAAARQDCLKSALLLCQRCRRLAGGCEEDVGMGEKEHFAEPLPDELLEAVELQEVIDGGGGGQGVDEENDDEEEGEVVEGIQDREGEAGEVDKETSVRTRSITPTATRGRSSLNGLPMARRGHGRRSRGSFSLRYALGAGHRGRSAKRPRYLEDYEGDEMEEGGDQFYCMTMGTKATKTEDVYADADVLYEDEVEAYGDLKPRNKARRGGLSNKGTLTDNNGYILMVNVLFSSLAKILGLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTE0</accession>
    <name>A0A0R3WTE0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4015</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003478">
        <property type="protein sequence ID" value="VDM23983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTE0"/>
    <dbReference type="WBParaSite" id="TTAC_0000403001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000403001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000403001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000403001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13927" checksum="C236A049D3572B40" modified="2016-01-20" version="1">MNAESTLELLLRYDDAKMASRSAAQGGVIEDMPSEEDQIVRNGWKLDANEDFVGTISRVRLVISASSFSRSCHSEHEPITRIVFLLHLVSALLVLFVVVPMLAVLWPVDIWLTAHIHSQVESGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTF2</accession>
    <name>A0A0R3WTF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4028</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003515">
        <property type="protein sequence ID" value="VDM24014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTF2"/>
    <dbReference type="WBParaSite" id="TTAC_0000404201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000404201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000404201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000404201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12228" checksum="B5E9178B4D535590" modified="2016-01-20" version="1">ASVHFATINIAFSHFINQWLSSCHAIPRLDPPRLPYARHLNSAKLTCSSLFNCDQQDPFVSRATELGLMLSPYIAVVLRLLGDKLETAARQFEVSGGGGGGDGGGGGGDGGGGGGGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH7</accession>
    <name>A0A0R3WTH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4051</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003567">
        <property type="protein sequence ID" value="VDM24070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTH7"/>
    <dbReference type="WBParaSite" id="TTAC_0000406701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="226"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="37516" checksum="6D1D198DBA3B08EE" modified="2016-01-20" version="1">MPILNILSSKAPSHVDPPTVKAISTEEIEVQWSAPSQSNGILKPYLVICSDTATYSDTHSATTKDNKTTSVIVEQLRPGREYRCCVVASTYPADRQDAEDCERRSALSNRIRTMALAPSRIPRPKGRAISSTEIQLTWSKPKHPNGILKPYQVTCLDVTHCSAPSRATTRDSETTSVIFGNLIPNTKYQCLIVASTIPAIGQDPLVCERRSELSAPIQTMPSTPSPVQRLRGKAISSTEIEVKWSKPKHPNGILKPYQVACFDTSHGSTPLMTTTTNNETTFVIVGNLIPNREYRCSVVASTIPAVGQDPLECESRSEMSPPIRTKLQRKLSSGVTVANLLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTM8</accession>
    <name>A0A0R3WTM8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L23, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4103</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003665">
        <property type="protein sequence ID" value="VDM24179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTM8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000411801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000411801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000411801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000411801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24902" checksum="384B33B91D950D61" modified="2016-01-20" version="1">MRPVIYFNPIAIPRTKHYVPLWRRHVVYPKFTPGDPQLRMFLPPFWMKMLYPGEKCPKRLVVFKIHPQMTKYDVKQYLEKIYRVPVIGVQLKMLYHDLSPLDTVEDPKRVAGAMFPHLLPRESERYEKVAYVHLAPGHEFEFPDIFKGGKRPSEEIYRLIDQAQIRNDLQPAKEDMEETEQLVKETKGTEGQKGSKPLQPSSPVINRWFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTV6</accession>
    <name>A0A0R3WTV6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS4181</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003850">
        <property type="protein sequence ID" value="VDM24366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTV6"/>
    <dbReference type="STRING" id="6205.A0A0R3WTV6"/>
    <dbReference type="WBParaSite" id="TTAC_0000419601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000419601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000419601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF390">
        <property type="entry name" value="PROTEIN KINASE C, BRAIN ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM24366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000419601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15900" checksum="0B2FCE90A6D5C092" modified="2016-01-20" version="1">MTYFLDSVTLEELEGYTAVALSTKLLHRVVLAERKGTDDVFAMKILKKDVILQDDDVECVMMEKRVLALQEKPPFLVKLHSCFQTMDRLYFVMEYANGGDLMYRIQQDGRFKEPVAVFYGAEIATGLFYLHANGIVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTX7</accession>
    <name>A0A0R3WTX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003894">
        <property type="protein sequence ID" value="VDM24413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000421701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000421701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000421701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000421701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14540" checksum="1725E8E1396025C5" modified="2016-01-20" version="1">MCMYQRVRTKNCKCVNRRHDNFTAPARLSKLNAIKHLSHCPIYLLYEVERHNRMKAATHCMSLRLVIRHSDMPSQAELLPPTLAAACSVTRGTNLRHLNWLLPTKCFSVLASAGKGAEMCENCEFHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUJ1</accession>
    <name>A0A0R3WUJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4417</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004362">
        <property type="protein sequence ID" value="VDM24889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000443101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000443101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000443101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271422at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133031" evidence="2">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000443101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16265" checksum="0544FCB2852E6C0F" modified="2016-01-20" version="1">MRFACVSLVPLLHAFQLLLLLLLFLLRHRNTSTHELTIKHPSKPSATVSPPCDTQPSPPNEVVRRDHQWNYLDSPLNLIPIPRAPIPTFGEVTPRPQVWHREDTFFPVLRNGSITVHGPSNYLLRVSSTPNRITLEITVKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVM7</accession>
    <name>A0A0R3WVM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTNNB1 binding N-teminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4803</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005385">
        <property type="protein sequence ID" value="VDM25683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000481701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000481701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000481701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000481701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15859" checksum="FEE893B4FF879B7C" modified="2016-01-20" version="1">MPAFGESSAINQPPRCNSRVHCPPPLPTVWTSHGIVAIFSFYTSFRAEEKFMAEECQSVEIHKDAECEGEAFCTSSLHTSTMEANQPSLDLDEVQFMDVEDVESSTDEHSVEAGASTSTPITGTCCLSGSAEVTAQHTELDLLQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW11</accession>
    <name>A0A0R3WW11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4935</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005711">
        <property type="protein sequence ID" value="VDM25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW11"/>
    <dbReference type="STRING" id="6205.A0A0R3WW11"/>
    <dbReference type="WBParaSite" id="TTAC_0000495101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000495101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000495101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133113" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM25910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000495101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20498" checksum="0F682B7A5D387AE7" modified="2016-01-20" version="1">MTTHTLLFTIFIATVYQVRVRTGNLHGGGTSAQVYLTLVGDASESGEFIFSNSKGRVFAKDREAVFKVEAAGLGKLTKIRLRHDNSGPSPDWYPRDVTVSEIGNSDERVYYFPCNQWLAATTDGSGRLVREFTAAPLRQRNVRPEDIPVSAYADGTAQMTQQSPPFKRSEDGSLTMLGTNIDIANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWV0</accession>
    <name>A0A0R3WWV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microphthalmia-associated transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006674">
        <property type="protein sequence ID" value="VDM26526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWV0"/>
    <dbReference type="WBParaSite" id="TTAC_0000524001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000524001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000524001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067843at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028213">
        <property type="entry name" value="PA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15364">
        <property type="entry name" value="PAXIP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000524001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21376" checksum="CCFA6DD15DF55333" modified="2016-01-20" version="1">MTYILGLSYLEAKKNETFTGGDQQEKKSDEIEVSEAQQQQLNFAEFDFDSETSAAAADTAALVAAQRRPLGGSARPVRERRVARLDKILQEDMVRRRLEMEQLRQQQQQHIQSETQQVQSTETTSMTEKGVGEQSTIAEVENAVSQPPPPSLESRPMEKNEGIAVSTDLPAQLGEMGITGEGNTALVGVATTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX16</accession>
    <name>A0A0R3WX16_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate kinase</fullName>
            <ecNumber evidence="4">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS5291</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01006902">
        <property type="protein sequence ID" value="VDM26630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX16"/>
    <dbReference type="STRING" id="6205.A0A0R3WX16"/>
    <dbReference type="WBParaSite" id="TTAC_0000530601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000530601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000530601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="13">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM26630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000530601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14338" checksum="17FA33C00CD448D7" modified="2016-01-20" version="1">MSVGSDFKLFGSSLTGIHNKQEIARSLLEHICNLDIDREPCAIRNTSIICTIGPACRTVETLQKMMTAGMNIARLNFSHGSHEYHLETIKLIRQAVETFRPFFRPVAIALDTKGPEIRTGLIDGVRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXQ2</accession>
    <name>A0A0R3WXQ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007839">
        <property type="protein sequence ID" value="VDM27155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXQ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXQ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000554201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000554201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000554201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10536079at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000554201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28061" checksum="394AE2EF15BD4E84" modified="2016-01-20" version="1">MWLRDEKNTLDVALVKEVDSGPLPRLRIQPRSLASGFYHVGLSARDRYADGREEMVDVDDGYIEILAAPLIIRLLNTSMSRVSVSQDSGDLCLRPEVYSIAPTNAQLIEARLPWWNITCTVVDAAYIGAECGIAELPSQKGSICIPTKWLQLHRIYKFMAVGRTLTQVGKGEIEIVVDAMGALGIRISALKRGLLWEGFDIHGAYISANATLVLTGRCSEACPKPYQWRIFEVRGGESTATELLPEALQSNVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZA0</accession>
    <name>A0A0R3WZA0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZA0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000610601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000610601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000610601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000610601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8396" checksum="80FADF27BD0BBB2A" modified="2016-01-20" version="1">MCAASTPLPLVVTSRRSANQSMDAANRSATQCLSLTRSLFMVVMASYKTRLKLLKALTDYKQAELTRRSNDNVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X003</accession>
    <name>A0A0R3X003_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6402</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X003"/>
    <dbReference type="SMR" id="A0A0R3X003"/>
    <dbReference type="STRING" id="6205.A0A0R3X003"/>
    <dbReference type="WBParaSite" id="TTAC_0000641701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13602" checksum="1590FA3EE27355C0" modified="2016-01-20" version="1">MTSSEGFDRVMARLGVDFLTRKAGNAAKPMIKLTEVNDGAEPKTYCLKNINTFRSTEVQFRLQEPFLETTPDGRKVKTVISLEKDDADGKWVLRQCQVGDKVTDIYRRLDDIDVMRSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0K1</accession>
    <name>A0A0R3X0K1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HDAC_interact domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020313">
        <property type="protein sequence ID" value="VDM30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0K1"/>
    <dbReference type="WBParaSite" id="TTAC_0000666401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000666401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000666401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6227134at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000666401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62205" checksum="C30D9F264E4C1D06" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0W7</accession>
    <name>A0A0R3X0W7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eph LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6789</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020323">
        <property type="protein sequence ID" value="VDM31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0W7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0W7"/>
    <dbReference type="WBParaSite" id="TTAC_0000680401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000680401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000680401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eph LBD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000680401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26294" checksum="4CDEBCE3DB608A1A" modified="2016-01-20" version="1">MLSEAGALSPQHEIKCCEHFNDGGGLHRLSILGRIQWRQQSRPGAGYSVYGLCESSSTAERDEFWLFGPLIPLGEALSVHVQVNFMLRSCADREIVDGRGGACRENFDVFLQQEALRSDMDVADIPQTESFKKLATISSDRKWSSTYPSEDTAVTSWLIRFRPQTERKAATIATKVATHSSNGWMRLAIRDQGACLMLDRIRIYYLTCPAWQLFWVVSKSTGSADDLEMHVVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X155</accession>
    <name>A0A0R3X155_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small integral membrane protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6890</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020329">
        <property type="protein sequence ID" value="VDM31170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X155"/>
    <dbReference type="WBParaSite" id="TTAC_0000690501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000690501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000690501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052506at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031933">
        <property type="entry name" value="UPF0767"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28599">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28599:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15990">
        <property type="entry name" value="UPF0767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000690501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10775" checksum="1CEAA60BF76FB6F6" modified="2016-01-20" version="1">MWPVIVQFIRVYTPYIALPFAVVVGFVGFGLESKLRSQDRLASTSATPTKTIDEVRLERRLKTTDDDLPGDWEDVLTSPKLRYRRDPMFDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1C0</accession>
    <name>A0A0R3X1C0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kibra</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6973</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020335">
        <property type="protein sequence ID" value="VDM31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1C0"/>
    <dbReference type="WBParaSite" id="TTAC_0000698801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000698801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000698801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278978at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000698801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="65660" checksum="27EB2D3C458AF738" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1T8</accession>
    <name>A0A0R3X1T8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fn3_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7186</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020351">
        <property type="protein sequence ID" value="VDM31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1T8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1T8"/>
    <dbReference type="WBParaSite" id="TTAC_0000720101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000720101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000720101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="4">
        <location>
            <begin position="736"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000720101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="855" mass="94498" checksum="1D9FD2285B2E2A58" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X291</accession>
    <name>A0A0R3X291_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SREBP regulating gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7376</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SPRING family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020367">
        <property type="protein sequence ID" value="VDM31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X291"/>
    <dbReference type="STRING" id="6205.A0A0R3X291"/>
    <dbReference type="WBParaSite" id="TTAC_0000739101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000739101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000739101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70142at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019352">
        <property type="entry name" value="SPRING1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481:SF0">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10218">
        <property type="entry name" value="SPRING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000739101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15198" checksum="2E197CE76FE68472" modified="2016-01-20" version="1">MEMPLDSPHFPKPSYNFSWISSVNQSLIQLSKEYCHHTVQGIFRVTDELGFFRYVLFLKLELWKRALELAKLKAQLDVLSATSVFEFCSARCRTSSESVVNTNAYRDPKHRFCFGIDPPELKLMSNSGNTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2F1</accession>
    <name>A0A0R3X2F1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7449</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020374">
        <property type="protein sequence ID" value="VDM31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2F1"/>
    <dbReference type="STRING" id="6205.A0A0R3X2F1"/>
    <dbReference type="WBParaSite" id="TTAC_0000746401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000746401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000746401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="119"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000746401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62895" checksum="8C94332FF81A5FC3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2G9</accession>
    <name>A0A0R3X2G9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoprotein TPR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7468</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020375">
        <property type="protein sequence ID" value="VDM31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X2G9"/>
    <dbReference type="WBParaSite" id="TTAC_0000748301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000748301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000748301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="71" mass="8142" checksum="56881CA8043D2C51" modified="2016-01-20" version="1">MIYVRTLTGQWMVLAQPHDLTSGQLVTNDILPNVDAVLDQMHQVNYDGYYLGVNGQWTYHNNNCQCFPPTQ</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A0R3X369</accession>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM32208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0000777301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286673at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="VDM32208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000777301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20888" checksum="4AE2C3D9C4DEB5E1" modified="2016-01-20" version="1">MLKRERTVASVVQLNVDVPIPTHQRTVREEEEEEEEEGVNLGAYNLYAKRASFKDDGVLQQFVTEMAGQPIISPPVLEQVEHVTQITDYCSIYLVVSSSKALSVRPVRQPQHHEKAEVTRSLEWGIIYEENFSCVSPGSLFLSLSLSIGHPNSERGDFCDVLFILAIHAVHKSLFILSPIHESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3A5</accession>
    <name>A0A0R3X3A5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7802</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020406">
        <property type="protein sequence ID" value="VDM32261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3A5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3A5"/>
    <dbReference type="WBParaSite" id="TTAC_0000781701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000781701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000781701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000781701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43992" checksum="4BE75F396E750835" modified="2016-01-20" version="1">MRILSKSIHKYLSGCISMIAENEEDMWLIYNLVQVGDRVCCSTVRKVQTENATGSVTSKTVRTNLTIEIETIDFDTHGSILHLKGKNVVENQHVKMGAYHTLQIGVQEKFTLHKEAWDTVSLLLVDQAGDPTQQADLAAVVMHEGLAYLCLITNSTTHVRAKIENTIPRKRANMPTSPHDKAIAKFFDQIIQAIERHVRFDVVKCVIIASPGFLKDHFFEYLCQQALRGAEDKRVLLDNKRKFLLVHSSSGHKHALKEVLADPAVVSRIANTKALGEITALNEFYQMLKADPSRAFYGVKHVQAAVDAYAVETLLISDALFRSRDLIERKKFVDIVDSVTKSMGTVRIFSSLNVSGEQLNQLSGIAAVLRFPVAEPQSDDEDDGNDSDEGEMVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3M9</accession>
    <name>A0A0R3X3M9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7950</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020425">
        <property type="protein sequence ID" value="VDM32427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3M9"/>
    <dbReference type="STRING" id="6205.A0A0R3X3M9"/>
    <dbReference type="WBParaSite" id="TTAC_0000796501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000796501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000796501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257076at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000796501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="25845" checksum="4CC910BF9DF612D8" modified="2016-01-20" version="1">MTSMSDVEACNLARDGKMAELVSRINADPGLVKLKDSSGRTVLHWSSCGGHIELVKRLIQGGCLPDEPDSSGWTPLMIAVSAGREDVVAYLLNAGLSVDVNVVNSTGQNCLHYAASKNRLSIARRLLLAGIQADLRDWGGNTPLHRAVSRGHTDMAKMLLAGVALADTGVNRDISKCSPNTPNDAGQTPLHIACEEGNTEIMKILLITGGDLTVKDKEGRAPGDLAPDNLRFSIQSDLKLQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3R3</accession>
    <name>A0A0R3X3R3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase_PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020428">
        <property type="protein sequence ID" value="VDM32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3R3"/>
    <dbReference type="WBParaSite" id="TTAC_0000800001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000800001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000800001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000800001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16384" checksum="BC205294F752A93E" modified="2016-01-20" version="1">MIAVWREFGLPNPRLHSQHHLTHSEKCPRLTEVQHRRRFATLLPTAYFDVVYKNALLMLKLRTASRVPWSVDVAVAVAVANAVVSTVDGDAVATAAEVPPVTMNARHFVGTEAADPDGMAVAIKVDIPLIVVVRAAAKAAAVDFGDKLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Z7</accession>
    <name>A0A0R3X3Z7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8085</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020444">
        <property type="protein sequence ID" value="VDM32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Z7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Z7"/>
    <dbReference type="WBParaSite" id="TTAC_0000810001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000810001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000810001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051765">
        <property type="term" value="F:inositol tetrakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000810001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32932" checksum="0859BE08F2716127" modified="2016-06-08" version="2">MVEESEELLFDPESISNLPDHLLVYEYQAGGHGSLAKWADYKMLRHPQESIVYKRLPPDKRGVLEANFYFKVFKVDAPPEIAKLRSIVPAFHGLFRDSNAGLYIGLEDVLAGLTNPSVCDLKMGRVACPPDASEAKIRAENAKYAHRDTVGFLFTGMKVYDQKSRRYLTVPRHYGRSLDSESVYFNALLPFLQGNLRLAQAFLPRLESVRSIFEDVPRPPMGFYRSSLILAYDQYQSNVVVRLVDFAHWRPISEIDDPSGIIHGLNTLISFLSRADVLPSVGYFAPFTVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X455</accession>
    <name>A0A0R3X455_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8160</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020456">
        <property type="protein sequence ID" value="VDM32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X455"/>
    <dbReference type="STRING" id="6205.A0A0R3X455"/>
    <dbReference type="WBParaSite" id="TTAC_0000817501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000817501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000817501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000817501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="525" mass="57878" checksum="723457951785505B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4Z0</accession>
    <name>A0A0R3X4Z0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8491</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020515">
        <property type="protein sequence ID" value="VDM33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4Z0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4Z0"/>
    <dbReference type="WBParaSite" id="TTAC_0000850601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000850601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000850601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269506at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000850601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="57788" checksum="7A1E80443C93B7BE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X573</accession>
    <name>A0A0R3X573_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8582</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020538">
        <property type="protein sequence ID" value="VDM33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X573"/>
    <dbReference type="STRING" id="6205.A0A0R3X573"/>
    <dbReference type="WBParaSite" id="TTAC_0000859701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000859701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000859701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66418at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000859701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="629" mass="71619" checksum="8974A628B7AB5CF8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5I6</accession>
    <name>A0A0R3X5I6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0587 protein C1orf123 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8717</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020568">
        <property type="protein sequence ID" value="VDM33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5I6"/>
    <dbReference type="STRING" id="6205.A0A0R3X5I6"/>
    <dbReference type="WBParaSite" id="TTAC_0000873201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000873201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000873201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000873201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18972" checksum="A5A7A76A554369B2" modified="2016-01-20" version="1">MPLFDLLLRARLTNVSELSPSGDDFQWCLKVKCSNCMEVHDKWVFICAQKQEATKGSRGFANLRLKCRFCGRENSAVVVEGSVKPYKEEDSEKLRPIVCLECRGMEPQEFSPRDGWQVISSSSCATVFPNVNLTDGEWMDFDVDGQCCVEVFEVQTDIKLRSQNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X643</accession>
    <name>A0A0R3X643_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8947</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020633">
        <property type="protein sequence ID" value="VDM33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X643"/>
    <dbReference type="STRING" id="6205.A0A0R3X643"/>
    <dbReference type="WBParaSite" id="TTAC_0000896201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000896201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22130" checksum="2F5162E95D236DEB" modified="2016-01-20" version="1">MSLRVLSKLRILPSSTARLTQRSASFLHSSILSIQFSKKVQPVLAPLSTYICARSLSETSSPPKLDKVLHDRLTELTTRTRVVVLMKGDPVEPRCGFSNAVCRILEAHGVLGKKDPTTGAPLLSSFDVLSDSETREAAKLFSDWPTFPQVFIDGEFIGGCDILLDMHRSGKLAAELERRGIGSLLTENGKDDSSKSPPSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Y7</accession>
    <name>A0A0R3X6Y7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9281</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020747">
        <property type="protein sequence ID" value="VDM34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Y7"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Y7"/>
    <dbReference type="WBParaSite" id="TTAC_0000929601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000929601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000929601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250802at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000929601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60788" checksum="F1EC6D9C3D14E3ED" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X711</accession>
    <name>A0A0R3X711_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9307</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PUR DNA-binding protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dymeclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020755">
        <property type="protein sequence ID" value="VDM34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X711"/>
    <dbReference type="STRING" id="6205.A0A0R3X711"/>
    <dbReference type="WBParaSite" id="TTAC_0000932201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6143152at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04845">
        <property type="entry name" value="PurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="78246" checksum="959AA1ECA3065DCF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7E8</accession>
    <name>A0A0R3X7E8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9458</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020828">
        <property type="protein sequence ID" value="VDM34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7E8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7E8"/>
    <dbReference type="WBParaSite" id="TTAC_0000947301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000947301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000947301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KA1" evidence="10">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000947301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="19950" checksum="AC8E26EFCE1389DA" modified="2016-01-20" version="1">MGANVAAPGGQLVSAAGRTNLALSGTRPGINPSTPVTSPQTAIMTTSTISSSASGGGTEKSDLVSGSNALDNRLVVGSSVEGGNDGTLKPRSLRFTWTMKTTSTKDPTVMLKEIKKVLTEQNCEYEQPETYLLVCRHGDPEADTCVQWEMEVCKLPRLSMNGVRFKRISGTAIGFRNIATRVSDALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7S9</accession>
    <name>A0A0R3X7S9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9589</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BORA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020906">
        <property type="protein sequence ID" value="VDM34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7S9"/>
    <dbReference type="WBParaSite" id="TTAC_0000960401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000960401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000960401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020858at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023252">
        <property type="entry name" value="Aurora_borealis_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728:SF2">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15280">
        <property type="entry name" value="BORA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000960401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="51362" checksum="AF00C6C8A08852E9" modified="2016-01-20" version="1">MAEKTPPRDIVSPSNPSSDLPVLTTPMGGRLYNPFHEDYVARLDGITVTPGLFAPSDRSVARTEAVKSIPFFWSPEIKGDHFPTEIDENLTHQLQMQQKLDADVEEAAQSKIASYFQSNVVAPSPDVTIKPLKELLSGKPTLHRTSSLKPIFTSGSGNEEQAGQRTVVVTDVKVQTSISVAPDTDLPSLLQRAMGLEEKENVLCGGESSSLYRYGVTFSEASADHTEDPYPRYPSVMYSSCLRENLPNYRKRRSLFSESFDVDTLRNATSSSVDARSVHDTHFISADDMEAMADDLGLPVNWASESVSLSSRHQCKRSPEDIDRFKQSSATNLTGLLEHAGIGSCRTLSCEPQKSHLFGSMSPLVGGRTSPEARGLQRPLPLSSIMNDEDDEYDGGDEESTRDSCKSFKRQCGHGSRKRRMASPDLSPIYRPCGNPLMDQDSDNYVDVDALPGTVAAANNDSESNESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Q2</accession>
    <name>A0A0R3X8Q2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrator complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9912</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021153">
        <property type="protein sequence ID" value="VDM34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Q2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Q2"/>
    <dbReference type="WBParaSite" id="TTAC_0000992701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000992701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000992701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000992701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127402" checksum="170A74565992E20B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Q9</accession>
    <name>A0A0R3X8Q9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3668 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9919</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021161">
        <property type="protein sequence ID" value="VDM34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Q9"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Q9"/>
    <dbReference type="WBParaSite" id="TTAC_0000993401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000993401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000993401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="690"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000993401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="929" mass="106044" checksum="E523B03404B897D5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8T4</accession>
    <name>A0A0R3X8T4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9944</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021181">
        <property type="protein sequence ID" value="VDM34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8T4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8T4"/>
    <dbReference type="WBParaSite" id="TTAC_0000995901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000995901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000995901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254995at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:myofibril"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF7">
        <property type="entry name" value="MYOSIN TAIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6" id="KW-0518">Myosin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="10">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000995901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31064" checksum="93622E22B3F4C387" modified="2016-01-20" version="1">MFAPRNTLLEEKKRLESAMMHRDEELEEAQTAREEAEDRYKRTLSLLEQAQVDLGLERTNAQRIETQRATFEKQIKELREKLAEQERDSGKRLKLQVATMEERLAAMDEQLENENKERQNANRAARRLDKRLKEVSLQLEEEKAYVVQLKDQLEKTQTACKRNKQNLEAMEDEASNLRTQKRRIQRDLEETTEQKEAFERELQMLRAKLNRGTRSAHRGSTGTSRPSTRTGGGTPEDAQSGADVDVSGSNEGTLNETTNSTTKNNSTKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAN6</accession>
    <name>A0A0R3XAN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10596</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021920">
        <property type="protein sequence ID" value="VDM35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0001061301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
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    </dbReference>
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        <property type="entry name" value="DEAD"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
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    </dbReference>
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        <property type="entry name" value="MTR4-like_stalk"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="110"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="346"/>
            <end position="542"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001061301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="579" mass="64868" checksum="8B969539C4490C19" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB40</accession>
    <name>A0A0R3XB40_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10750</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022186">
        <property type="protein sequence ID" value="VDM35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB40"/>
    <dbReference type="STRING" id="6205.A0A0R3XB40"/>
    <dbReference type="WBParaSite" id="TTAC_0001076701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001076701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001076701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001076701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="47175" checksum="C355BDA69F6D03BA" modified="2016-01-20" version="1">MAQQHSRIIADGAYALWEDKLISTVSGIQLNGGQNGQLQFSLRSVWALKSLGGSVSHRGGSSGGNIFDDLGGASPGRQLVEQRIFQITSDGSIETLVEFDREVVAMYLLNVAVRDNGSQPLATSTSLLVRILDENDNTPEWTFPTESARQINITTANPPGSLVARLQAFDVDADDAGKVEFQVLDLNGQPMPPVSISRGLYNAPAQPPQPTSTAAQEELMGYRTGPFYLNGSTGEILVADRLVPLNLKIRLRAIDCGHAQRLFTDTWMGINVKMDPNEFGGFLGGGRAGALNVTIILVMIAVTAIISLLLIIAIVCVRRKPARTVVSNGTAAEPEGRVVTYSPGSPFLITDPSKEALTTNTWTGSSKDFYPPLSGGLPVDENGRSTGGISYGSPLLGSDKTSVFCGVPPQGSIYTPLEPNGDIISGTLPMHTFGVSVGEQFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC26</accession>
    <name>A0A0R3XC26_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11086</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022912">
        <property type="protein sequence ID" value="VDM36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC26"/>
    <dbReference type="WBParaSite" id="TTAC_0001110301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001110301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001110301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001110301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10258" checksum="2551A5586522FF25" modified="2016-01-20" version="1">MKEDIATTVVEFSNDQSYLPTIQKKEEEEEEEEEEERKVDGFVKLEATRVLYCNQSNPTNRLKWVKGKVRKEEEDEQEQEQDSEACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC29</accession>
    <name>A0A0R3XC29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11089</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022929">
        <property type="protein sequence ID" value="VDM36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC29"/>
    <dbReference type="STRING" id="6205.A0A0R3XC29"/>
    <dbReference type="WBParaSite" id="TTAC_0001110601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001110601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001110601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10525226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001110601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17714" checksum="22AF52867D8715EC" modified="2016-01-20" version="1">MPVVTAQGPAAGTGETVPAPVETSPSPQPPATTTSSNQNSNAKIQEQVKVVINDLAKKLHVPPSAVIAMVVGFVLFLLLILYCICKRGIFKRRKKEKPGKKKVDMKSVQLLGKQLGKDQVSSSHFDCLLQLNYGLTFSKFSSQNPPELMENSQLSDLNQPLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC30</accession>
    <name>A0A0R3XC30_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022938">
        <property type="protein sequence ID" value="VDM36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC30"/>
    <dbReference type="STRING" id="6205.A0A0R3XC30"/>
    <dbReference type="WBParaSite" id="TTAC_0001110701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001110701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001110701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043073574" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001110701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23588" checksum="A665E358A4E48ADF" modified="2016-01-20" version="1">MDTVWCLIILLSGIAIAAPNSKPSLPTLPIGTLLAQDVAHFLSVFKDFSKDSIKDVHYAYIGSSVFNQNFVEDFPCDQLKLHFDSLDAEMQYYSLSAARGVKSCAPKVSQPNQLKDALQKEKLTVDQLYYLVSSANIAQVSINKEVVLKLLATFAAKETGPSGLSTILATASIVKGATSKELEPFFHIVAKLVDQADEVDGSILFVTFNFASHRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCC1</accession>
    <name>A0A0R3XCC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11180</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01023136">
        <property type="protein sequence ID" value="VDM36160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCC1"/>
    <dbReference type="STRING" id="6205.A0A0R3XCC1"/>
    <dbReference type="WBParaSite" id="TTAC_0001119801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001119801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001119801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279736at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF519">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001119801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33016" checksum="7FDB966262949BAF" modified="2016-01-20" version="1">MSKNVKRGFRIALQILALILTLAYFSTAITGVVLRVSKGWLETALSNDFDGYVGDEENLRQFAIFVLELADRMSIYGIATGFILALLCLVGLIGSWYNWRKMLNIYSGILVVFLIAQIVIANVAFPSPITFSKRMYNSTEELLKFYGDKGEKGEKATGVWNVLMETYPQCCGMEGYKDFGKLKGHTWLQCVKVCAIKPLPPLAEDLGKALPPACCNMTSGVCHDFIAKNVGLMGCKSKIELIGILRSEAVLSVTVAIIMAQLLLTLLVLAFSCTTEKEEEKESRSKLLTDTQNSILTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCT3</accession>
    <name>A0A0R3XCT3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11343</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023717">
        <property type="protein sequence ID" value="VDM36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCT3"/>
    <dbReference type="WBParaSite" id="TTAC_0001136001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001136001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001136001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001136001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9761" checksum="2F249B9C6BF35B50" modified="2016-01-20" version="1">MFFLGNSPPTFTHQKLVELCPGVEQGKRPRHQESYSSSIDAAAMDAHLDALAETVEELEGLSGAFVSAHRERGRALAYRLTAIFSSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCU0</accession>
    <name>A0A0R3XCU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11351</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023747">
        <property type="protein sequence ID" value="VDM36331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCU0"/>
    <dbReference type="WBParaSite" id="TTAC_0001136701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001136701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001136701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001136701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="6125" checksum="08513BA920ABBC6C" modified="2016-01-20" version="1">MRKERRKTKKQEEKYVQMMEKSEEEEEESVAARWMKISDVVRGDLWIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCZ6</accession>
    <name>A0A0R3XCZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Movement protein BC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024028">
        <property type="protein sequence ID" value="VDM36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0001142301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001142301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001142301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10624961at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001142301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21304" checksum="2D291B692BEFC61A" modified="2016-01-20" version="1">GISAIEFRCSAKAQIPFPHVTSQYEIVHSGRVVGLNRTERSMHSFDSLIAVSQSYRDVFNLGFLPHFRLADRTWRRSHESYHSIHADFNSTPQLIKSLSCVNVDDTEEQEGGEQMSISQRIAQIQENSEQWKRRSQVRIENEVTPLKSVNQIRNDLAVSQQQWRKRVVPQESDTVKRISCNPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD29</accession>
    <name>A0A0R3XD29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Equilibrative nucleoside transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11440</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01024206">
        <property type="protein sequence ID" value="VDM36502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD29"/>
    <dbReference type="STRING" id="6205.A0A0R3XD29"/>
    <dbReference type="WBParaSite" id="TTAC_0001145601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001145601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001145601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM36502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001145601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35548" checksum="807F7BDE868ECF04" modified="2016-01-20" version="1">VEFSIESGSDIHCITEGGEEEVGVNIGRKSFFFNYYFTHCREEGVRNYTTLEALKTVDFYLAFLINFFNSALTGLTSSTVKTYGRECGFDNNFLVLVLTLSSVFNCLGRLTWGVIGNRYSFKVSLADLIFTSQGRPFYLTDTGCLFLPLEVPLLVLQTEWAFLWLTYGFVTQVGGIAAKALFAVWTFLLYTCLAANFVLIPNLATRIFGPKSMPTIFGLLFTAMVCGFHTLILSGVFAQYDIRGQWIPIYCAGAGFAIIGLILTLFLRDPVEFGCIAWLNTCVQISDCCRTEPREEVEEAGEEEWKTTDSTIKTDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD93</accession>
    <name>A0A0R3XD93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhoLip_ATPase_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11503</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01024569">
        <property type="protein sequence ID" value="VDM36768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD93"/>
    <dbReference type="STRING" id="6205.A0A0R3XD93"/>
    <dbReference type="WBParaSite" id="TTAC_0001152001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001152001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001152001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001152001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17317" checksum="3B9BE166D59FED2A" modified="2016-01-20" version="1">MLKHYVPQVYIFSLFWFQFFNGFSGSAHINQLAQVLFNVSLTSIPPFVLGALDNSLDDRTLMANPKLYRNGRDSMTYRPWHFWLNTLDAMWQSLVIFFIPYLVFNGTNASMDELGTTCMNALVFIALVHIALETKCFNFLGEQEVDPECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDD4</accession>
    <name>A0A158RDD4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS416</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000034">
        <property type="protein sequence ID" value="VDM16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDD4"/>
    <dbReference type="STRING" id="6205.A0A158RDD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000041501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000041501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000041501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="11">
        <location>
            <begin position="54"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="12">
        <location>
            <begin position="475"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000041501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="733" mass="79125" checksum="347FA3D193370558" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDI7</accession>
    <name>A0A158RDI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS700</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000080">
        <property type="protein sequence ID" value="VDM16862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDI7"/>
    <dbReference type="STRING" id="6205.A0A158RDI7"/>
    <dbReference type="WBParaSite" id="TTAC_0000069901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000069901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000069901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="3"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="320"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="641"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="933"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM16862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000069901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129239" checksum="656B856CC78DBE81" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE18</accession>
    <name>A0A158RE18_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6489</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE18"/>
    <dbReference type="WBParaSite" id="TTAC_0000650401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000650401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000650401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000650401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13559" checksum="76897454EA4DB74D" modified="2016-06-08" version="1">MNRLHQCTTQPTEEDNMRESETVRVDGMRWVMEWMHRGVEQRWCIIESPQKLQCCCIVMEDHCWTLERLRGHIFWLHAIDEERSCSKLEAATDPPLAIHGVRLDGVDHSPSPCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REK3</accession>
    <name>A0A158REK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">EH domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7445</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REK3"/>
    <dbReference type="STRING" id="6205.A0A158REK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000746001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000746001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000746001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="445"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000746001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63394" checksum="E1030C3B270D6AC0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REN0</accession>
    <name>A0A158REN0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 17">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS7625</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="17">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="17">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 17"/>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REN0"/>
    <dbReference type="STRING" id="6205.A0A158REN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000764001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000764001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000764001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="15 17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="18">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="18">
        <location>
            <begin position="312"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM32038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000764001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="65366" checksum="FFA204890BBE58DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REN9</accession>
    <name>A0A158REN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7710</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REN9"/>
    <dbReference type="STRING" id="6205.A0A158REN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000772501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000772501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000772501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000772501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42247" checksum="5F92313A37B4A2F8" modified="2016-06-08" version="1">MVYPVRRNDIAVKENSPVGTVVGQVSVRDADLTEANRRVRFLLRGRPEDLFLVDIDRATGQLSMRRPVDFEKQSSISLTVIAENEAPLATPSVGGSSMTTAAYHTEASVIISVLNLNDNRPEFVLISPHRKHIIFAWEQLPLPGANQTLRDQRRFCEPIPYRVIDRDCDPTSRAVCCTLELDDTFDGMFGLYEEIPNVLCALKRPPQPQSFKLLLKAHDGTGNDSLSSQIQLSVIVKSEPDYTKFIQKGSPVASPLGSRISAVEGGAAAQEGGGAKGTMSGGPSHGSRQDPPLRAQENINRGEKLSDAVAPSSSPTFPPSSHQMKVISVLVSIAGIFCILLLFIIAALRCGLLDSQREWKIITDFFSHSTFPVQISTKTVMPHGMSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF67</accession>
    <name>A0A158RF67_HYDTA</name>
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        <submittedName>
            <fullName evidence="11">Ligand of Numb protein X 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9022</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM33727.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16637">
        <property type="entry name" value="mRING-HC-C3HC3D_LNX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="298"/>
            <end position="336"/>
        </location>
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            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="509"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
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            <end position="697"/>
        </location>
    </feature>
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            <begin position="760"/>
            <end position="834"/>
        </location>
    </feature>
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            <end position="154"/>
        </location>
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            <end position="260"/>
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        </location>
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            <begin position="727"/>
            <end position="751"/>
        </location>
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            <begin position="88"/>
            <end position="99"/>
        </location>
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            <end position="130"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="136"/>
            <end position="153"/>
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            <end position="257"/>
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        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000903701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="850" mass="89006" checksum="6D67234595224712" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF82</accession>
    <name>A0A158RF82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IRS-type PTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9162</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020698">
        <property type="protein sequence ID" value="VDM33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF82"/>
    <dbReference type="STRING" id="6205.A0A158RF82"/>
    <dbReference type="WBParaSite" id="TTAC_0000917701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000917701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000917701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259276at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="263"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="687"/>
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    </feature>
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        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
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            <end position="131"/>
        </location>
    </feature>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
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            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000917701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1050" mass="111812" checksum="B26CA93B963F962F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EJY5</accession>
    <name>A0A3P7EJY5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dyp-type peroxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
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    <dbReference type="OrthoDB" id="76259at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="219" mass="24139" checksum="0DFEE17CCC157803" modified="2019-02-13" version="1">MVHAVCDERGKLFELAQTVLNDMPKGAVQRVEETYGFTYRDGRDLSGFVDGTANPADTTDRIVAAVSETTGGSYVLTQRWLHDMKKIATENLKTMEANVGRTRDTNVRIEPIAPTSHIGRVKRSAEDTSGTGGRMVRHSLPYGTASGECGLFFIAYARSPHIFEWALDRMTGLSHDHIEDGLFRFTRPLTGAYFYSPSRVELENILRGGGGFGGRSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EMM7</accession>
    <name>A0A3P7EMM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003654">
        <property type="protein sequence ID" value="VDM24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EMM7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="141" mass="15654" checksum="283D563D5E7D6075" modified="2019-02-13" version="1" fragment="single">MNSIDSRVSMSFFRPPLIPGRIQKTRSDILNSIDSLERALRLATTLLSPNICFIIAHLTSAIRNIRSNISDSICTDDYFPLSSVESMAGLMAPILFPTLSETKVTRNSGVECCEWREVLLSTLFSVDDGKCIEPIELLSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EUF4</accession>
    <name>A0A3P7EUF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001068">
        <property type="protein sequence ID" value="VDM20007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EUF4"/>
    <dbReference type="OrthoDB" id="6274357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="109" mass="11740" checksum="4ED8FD0EC5CA22DC" modified="2019-02-13" version="1">MKVEPPTEFVFPPQPVKKCVYSTVFKTEPTTEVILPPQPVKKCAGSAVFKAEPTAEVMVASPAVKECSGSSECALSSKSVKSCPCSIEDEELTDGLQALFKLFRALKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EVD6</accession>
    <name>A0A3P7EVD6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003438">
        <property type="protein sequence ID" value="VDM23936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EVD6"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KEN" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM23936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="226" mass="25257" checksum="BEAB49BA876EBE2E" modified="2019-02-13" version="1">MTQLLRAIRNKRNHIWSLRNTVRDVLGSSDTAMAQHWNSRFPSLLPLTYCLARVHLAKVDHFRRFLPAPLTSDAAERFIGDCCHPSAPAMWARLPTSEKVVNGINSCAETNNNIADIKLQVSEHGSPLQAKSRVWSKVRNSTNPWHLPSRRLVPGEASSKDAAITTFAKTVAAALPPPMTSVSGEMADSAERMEETDTEDGFVFQRTRKRTRKRKNAPNNAKTMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EVQ5</accession>
    <name>A0A3P7EVQ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008483">
        <property type="protein sequence ID" value="VDM27410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EVQ5"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="131" mass="14747" checksum="04A6D0416C200C04" modified="2019-02-13" version="1">MRTRFSAGTPNQISNLLEVDRETAVAGCTDWRCIDFIRWKEPSIISGGRDSCCYLSQSHGNEALELASNPEELISISAKHSLDISLFSLTDFRPSLAESLQKEFGVDMFLFNDCDCFIQYTIPSGKFRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EWQ1</accession>
    <name>A0A3P7EWQ1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001319">
        <property type="protein sequence ID" value="VDM20747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EWQ1"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM20747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="301" mass="33148" checksum="DCF2B7A025C38E2A" modified="2019-02-13" version="1">MSSMGTILQEFSKFKRSEEAQFKALVCIGLKLFNFTSKFSRVIHGIGECDINERKSSLKTNNIAEQESDCPYLLLDVRDKDDFNQCHIIKAVNYPYTLLSRCINFEIREMLAFRNKPGHIIICYDEDERLAPYVATVLTERGYENIFVLSGGLKVGWKLFPKGLILGDAPVALRSKLGKRPRYEKNILRLSSASISNSAPSISSVVDDDGASSALGSTIGRRSTISSARRAVRYTFDTYEAVGSRGTPNGGENFSMIDLAHLSLALDALCANSRVNKTSGTNTANSVRSRASSASTLKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZJ6</accession>
    <name>A0A3P7EZJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005132">
        <property type="protein sequence ID" value="VDM25486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZJ6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="336" mass="35413" checksum="D5548DE97D165219" modified="2019-02-13" version="1">MASGAELECFTRDGLTPLHCASRSGHAQVVQLLLNSGANFSAKTRSGLTALHMAAQGDHPECVKLLLFQGAEVDDVTIDNLTALHVAAHCGSVRVAKVLLDAHSNLNARARNGFAPLHIACKKNRIKVVELFLKHGCMVDVATESGLTPLHVAAFMGNINIVVLLLKHSADPNGQTMHNETSLHLATRAGRIETVKLLLRNGAIVDAKSRGNQTSLHVAALLGNCELITVLLQNGANVQAVTKDGHSALHVATKAGHDEAISLLLESGAQADVLTKSGFTPLHLAAKYSRLRPAQLLIEAGAQLDIPGRNGLTPLHLASHYGSVSVVKALLDKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F9E4</accession>
    <name>A0A3P7F9E4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS4583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01004815">
        <property type="protein sequence ID" value="VDM25227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F9E4"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM25227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="175" mass="19825" checksum="8E71AF1FEBD10CE9" modified="2019-02-13" version="1">MYDVNERIGRGAFGEVFKGVDKRTLRPVAIKRIDLEEALDELEDIQQEISILSQCDSPYITKYYGSYLKGTKLWIIMEFMGGGSALEIRKAVKIDEPNIATILHEVLMGLAYLHGEGKLHRDIKGQLCFHSHILFSLISSNQNSEPPLAFSLQNFIVISLNFKNTEAIAFFQPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCA0</accession>
    <name>A0A3P7FCA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006581">
        <property type="protein sequence ID" value="VDM26464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCA0"/>
    <dbReference type="OrthoDB" id="5574452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="75" mass="8672" checksum="F99E62CF13A0061E" modified="2019-02-13" version="1">MKLLDQNIDPGLRQDHVVKIRPNPIPSNNAYLKRPSSERNQCFGSPRFLELDYLHSKDFVVDNTLFIKAIFDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FE30</accession>
    <name>A0A3P7FE30_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA ATPase AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020836">
        <property type="protein sequence ID" value="VDM34280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FE30"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000025">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="5">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11622" checksum="B41A35C289E48615" modified="2019-02-13" version="1">MALLHINLREVLLDDDVKLEEIAEKLAGYSGADITNVCRDASMMSMRRAIEGLSVEEIKGLRTADLNLPTRMRDFEEAISRVSKSVSAADVGKYEKWMQEFGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGI0</accession>
    <name>A0A3P7FGI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008599">
        <property type="protein sequence ID" value="VDM27457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGI0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="82" mass="8839" checksum="D7AF14022C98D354" modified="2019-02-13" version="1">MGPAVALKSRTNSSGQLLSHAVSSDPLLTSIPAPGTVANPIPLQGHMLQRIHFRVPAVCKSSRDFRIFNTHCGVFTDLWASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FJN6</accession>
    <name>A0A3P7FJN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023453">
        <property type="protein sequence ID" value="VDM36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="262" mass="29230" checksum="5AB22AAB29ED1BAA" modified="2019-02-13" version="1">MLPHRKGAEEENYTRFSLAEALAYGRVEIDDREAWLCGRVKRPCLVIQVDVWEMEDVGDAILSEDQLTLFWNTDFDIESDMKSCLTGNYFPLASCRVPLSDLLFSGVLPPRWITLLRAPSPPARLSDRNRCYRLAGALEISASFGAVSTRRKVLEEVLSQASPLALQSLHSLGFNPVVESVSRICLSPEKAGMNEGKCQLTLYFSAAHLPTEESLLNPEEVEACEERGIQGYFFARAVLGSDFQISNSHPLPXXXDEREIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FRV5</accession>
    <name>A0A3P7FRV5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020381">
        <property type="protein sequence ID" value="VDM31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FRV5"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20557" checksum="CD9B920F9F34730F" modified="2019-02-13" version="1">MGDISYLPKCENNPMRDIRIQKLCLNICVGESGDRLTRAAKVLEQLTDQQPVFSKARLTVRTFGIRRNEKIAVHCTVRGAKAEEILERGLKVKEYELPKSSFSAMGHFGFGLTEHIDLGLKYDPSIGIYGMDFYVILGRAGQRVCHRRRCVSKIGLKHHVTREEAMKWFQSKYDGILINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FUN3</accession>
    <name>A0A3P7FUN3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023567">
        <property type="protein sequence ID" value="VDM36286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FUN3"/>
    <dbReference type="OrthoDB" id="6267905at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9394" checksum="F871A58A973B9544" modified="2019-02-13" version="1">MPMDPVRLMHELYPDLEISEVECLSKNSASDNSNVASSGKREDVQVAGQRVRVMAKYKGRWLSGEGINVRTAKLKIAEQLGIGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G266</accession>
    <name>A0A3P7G266_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021492">
        <property type="protein sequence ID" value="VDM35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G266"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="237" mass="24038" checksum="1AAF0340151DFC0B" modified="2019-02-13" version="1">MDWACLGWRRGSLGGGGGGGGGDGGAVADIGDGVNCAASRGSVVDREANEKEKSKPLPTLKDNDFMNDICELHLEESAKERLLEHLERDIAENNLMDYSALIGIHDVELAVDNDPEEGSGTGVGFFTSASPITMEMGSSATAGSVGVVGVGGHRGSGPEMLASAGDGLGEVFEERLFGPNHSAASFIPSSFPMSSFTHPGGGGGGSVGIGSEPFSDFSPPNSENFDTLVAGGSAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G543</accession>
    <name>A0A3P7G543_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021672">
        <property type="protein sequence ID" value="VDM35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G543"/>
    <dbReference type="OrthoDB" id="10393389at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="183" mass="19058" checksum="2AC000BF6A2F3233" modified="2019-02-13" version="1">MVLQAFLVSYFSSSFSALKISLNELLWAVENRNWSKNLSNPNLHFDSNPTRWLSSAPHPPVSSASPGSPLKTSDGTDRDGLELVNLASSDSGSGTGGVEATVGSRGTSSLVHKAPILLGGVGGSGSGSDAVEQLVGSETSTQSDGITAMLKLHSRLGRILQDACDLHKQIGHLLSTVANQPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJW8</accession>
    <name>A0A3P7HJW8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01021958">
        <property type="protein sequence ID" value="VDM35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJW8"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="253"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="389" mass="44011" checksum="0649817BC91166F1" modified="2019-02-13" version="1">MKALQRQRQQQAEGLDESEALNERRARSCDEWGEDDGAERNKRGELSRLTECRPSAQDGINTYFMEAVRRRRLEAEDEIEGDKTAEGGVNTHYEAIDEDDDEVAELREIGIDLEAAATESEDQEGTGDDDAMKTWQDVGNLRPEGSTFFASKTASEIGGAEVVELERGDEGDEEHGDELLLDRGQTEVTQSSAKGMDPRRINFVKSLHHRFTNYIYDTSATRSWVKLTISMFDPKDGRISIDLRTLVQRIISKSIVSFVPGIQKAFIDKTDPKKWVLRVEGVNLKVLSCYGNVFDLTKLYTNHVPAMQEHFGIEAARASLLREISSVFGHYGINVNPRHLKLVADYLTKTGLYRAFNRRTMEFHPSPMQRITFETATNALKSVIQESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHX8</accession>
    <name>A0A0R3WHX8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM16007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHX8"/>
    <dbReference type="WBParaSite" id="TTAC_0000016901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000016901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000016901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000016901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8199" checksum="5CFA2681A8B2198B" modified="2016-01-20" version="1">MEQSSGGSQAGSAHSTVQENACREGASGGTEVSLSNSEFVGVEGGGGDDGGANVVAGDAMMCPMCAFSSCDREAIMQHVMGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI72</accession>
    <name>A0A0R3WI72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5742 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS281</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000020">
        <property type="protein sequence ID" value="VDM16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI72"/>
    <dbReference type="WBParaSite" id="TTAC_0000028001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000028001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000028001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043984">
        <property type="entry name" value="DUF5742"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19013">
        <property type="entry name" value="DUF5742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5742" evidence="2">
        <location>
            <begin position="202"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000028001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="648" mass="71480" checksum="C6AF46E13217642E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIH7</accession>
    <name>A0A0R3WIH7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS403</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000033">
        <property type="protein sequence ID" value="VDM16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIH7"/>
    <dbReference type="STRING" id="6205.A0A0R3WIH7"/>
    <dbReference type="WBParaSite" id="TTAC_0000040201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000040201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000040201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF72">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="18">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="157"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000040201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62004" checksum="805B1A8FF37FF0D3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIW2</accession>
    <name>A0A0R3WIW2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS569</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000057">
        <property type="protein sequence ID" value="VDM16664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIW2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIW2"/>
    <dbReference type="WBParaSite" id="TTAC_0000056801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000056801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000056801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="105"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="292"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
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            <end position="575"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000056801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="775" mass="88507" checksum="55B9F929DA287E51" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIZ7</accession>
    <name>A0A0R3WIZ7_HYDTA</name>
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        <submittedName>
            <fullName evidence="6 8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS612</name>
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    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="VDM16741.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000061101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113521" checksum="B943BADDBE1F3E0A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ89</accession>
    <name>A0A0R3WJ89_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS726</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
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        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000084">
        <property type="protein sequence ID" value="VDM16901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WJ89"/>
    <dbReference type="WBParaSite" id="TTAC_0000072501-mRNA-1">
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        <property type="gene ID" value="TTAC_0000072501"/>
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    <dbReference type="OrthoDB" id="73614at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000072501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8126" checksum="6ADCF6386983EE82" modified="2016-01-20" version="1">MLIYHYICFHVSTFFLVGPVKQCKRMFAESRIVAALLFLYHKAALCLLFSILQFIALTWYSLSFIPYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK74</accession>
    <name>A0A0R3WK74_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1108</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FOXJ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000185">
        <property type="protein sequence ID" value="VDM17479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK74"/>
    <dbReference type="STRING" id="6205.A0A0R3WK74"/>
    <dbReference type="WBParaSite" id="TTAC_0000110701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000110701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000110701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20023">
        <property type="entry name" value="FH_FOXJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047512">
        <property type="entry name" value="FH_FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047513">
        <property type="entry name" value="FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000110701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="722" mass="80753" checksum="5F6941F64FFDF726" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK94</accession>
    <name>A0A0R3WK94_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial inner membrane protein OXA1L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1130</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000190">
        <property type="protein sequence ID" value="VDM17511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK94"/>
    <dbReference type="STRING" id="6205.A0A0R3WK94"/>
    <dbReference type="WBParaSite" id="TTAC_0000112901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000112901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000112901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="11">
        <location>
            <begin position="110"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM17511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000112901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45232" checksum="565D8996973E74E0" modified="2016-06-08" version="2">MAFVRAADALLARLKSASFYRTRISRLLWTVTSNDSVKITKCITSFPLLATCTSDRIPDIPQMPPIEDANIPLNALGEPTFASLGLNSYWPSGWYQAALEFLHVDLNLPWWAAIATTTVVIRLCLIPFVINQRRKLASYTNVMPQIHALQNRMTRARVASDYIEMMKVSQEMQQLMKNNDVNLLNSMGLALIQVPIFLSVFAGLRGMAQLPVESLQTGGLGWFADLTVCDPFYVLPLYSMSSIFLMFEFGADVSSQGLTTGVRLAMRIFPVVGFFMIMHMPSALLWYWSISNTISISQALILRTKPVRTYLKFPEKVNPPPQLGRKKGFVEGFKESMNNSRLLAELEARERMDAERWQKAGMGPIPKTFAYDIRTRTKKPVVTVRGTSVPEKDQSQTVKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKX2</accession>
    <name>A0A0R3WKX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1381</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000287">
        <property type="protein sequence ID" value="VDM17897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKX2"/>
    <dbReference type="STRING" id="6205.A0A0R3WKX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000139401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000139401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000139401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="136"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000139401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="755" mass="85427" checksum="986C2E7C9FCA36F2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN36</accession>
    <name>A0A0R3WN36_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS2161</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000811">
        <property type="protein sequence ID" value="VDM19079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN36"/>
    <dbReference type="STRING" id="6205.A0A0R3WN36"/>
    <dbReference type="WBParaSite" id="TTAC_0000217401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000217401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000217401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66906at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="15">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM19079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000217401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="728" mass="81926" checksum="C553583802B9D465" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNG6</accession>
    <name>A0A0R3WNG6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2291</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="UYWX01000931">
        <property type="protein sequence ID" value="VDM19530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNG6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000230401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000230401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000230401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000230401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11483" checksum="295CC3FF1CA114C4" modified="2016-01-20" version="1">MGVDVEVIKPGDGTSYPKKGQTVSVHYTGTLTNGKKFDSSRDRGQPFQFKLGVGQVIKGWDEGVAKMSLGERSKLTISPDYGYGSAGAAGVIPPNATLIFDVELLSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNT4</accession>
    <name>A0A0R3WNT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CYCLIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001046">
        <property type="protein sequence ID" value="VDM19942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WNT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000242201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000242201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000242201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272950at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000242201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43724" checksum="67DA09040E82BCB1" modified="2016-01-20" version="1">MANAQLIARAKRGLQTMGEVARKNLRILPSTYEFMHTFRGRWSRKSRDKVNDIQMCPLNEYTDAEWNREILYFRRILHYELMRDDSLIREYNSNCLSMSELNPTMRAKLFDWLIRVMQEKVQQYYKLPSEALHLATTMVDRFTWCRLTSPEKYQLVGISAVVLGVKLTTRKMPLSFDDLCHLTEDTYSAAEVQRKEEKMLRAFDYALVYPIPHTFIAFSLIGFEDLPKGVNENVIILLCRYIFDQGLTELSLAKCTASLKCAAALYLIRHLLRLICQCPLKHRKCCPFHSMTPWTDKMTGVTGHREAKALRKAAFTYGLMLIEAQFFLNEMTPGLMTGCGSSLRAAFKKHSQESRSCIARHPLVTKFTISDILNLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNU3</accession>
    <name>A0A0R3WNU3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2418</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001058">
        <property type="protein sequence ID" value="VDM19973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNU3"/>
    <dbReference type="WBParaSite" id="TTAC_0000243101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000243101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000243101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6508643at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF271">
        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000243101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36869" checksum="B73EDFA1B671FF63" modified="2016-01-20" version="1">MSFHQHRQYFQYHENGTPLKESATHSFLTTNYLSSSSSSSWQSSSLSTNCGTLSAEPLDLRINDKCRHRDGSGVNSSAILLLNLFKANALFGGLIKRFKEEAINRDVSSEESSDESESIPSVISFEKKRGKEGGGKAAQIHYRPEKLGSREMVQEMLRNKDPELRYINDGEAIMNPFAVDRKTQLADLMKMFCREKASGGYKCEACGRERQLIREMQQHLLCHSNSKFYLCVRCLKGFNDTFDMKRHTRKHTKGHLKRVHAMQLHFARHQRREVLRVCECCGFTCDHYAQLLAHTEYHHPSNQDAINRLRKRIIAAKRNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP00</accession>
    <name>A0A0R3WP00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001123">
        <property type="protein sequence ID" value="VDM20154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP00"/>
    <dbReference type="STRING" id="6205.A0A0R3WP00"/>
    <dbReference type="WBParaSite" id="TTAC_0000248801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="577" mass="62173" checksum="056287F1D2D6895B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP32</accession>
    <name>A0A0R3WP32_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2507</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001156">
        <property type="protein sequence ID" value="VDM20276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP32"/>
    <dbReference type="STRING" id="6205.A0A0R3WP32"/>
    <dbReference type="WBParaSite" id="TTAC_0000252001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM20276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47174" checksum="3B3614A0E76F1444" modified="2016-01-20" version="1">MGWGFYTCGPNEALVVSGCCHNKPYYVPGGRVFVLPFIQRLDRISLNIMTLIIESPRIYTRNGVPITVTGVAQVKIQSSNSDMLSAACEQFLGKSEREIQEIAKETLEGHQRAIMGNMTVEEIYKDRKLFSRSVFEVASSDLVNMGISVVSYTLKDVKDDEGYLEALGMARTAQVKRDARIGEAEARRDAGIRAAQAEEARMAEQLRTEASIARSQRDLALRRAACDREVRALRVKAELAYQLQAAKTQQAIRAEAMAVELLERKRRIELEELERQRAHFRLEAEVRNPAASDCFRIRALAEAEQTRLTAEAEAEADAIKVKGLAEAEANRAVALAEAEKMRRVAEALKNYQGAAMLDMVLQTLPRVAAEISSPLANCNKVTMVATGDGEVGVAKLSNEIIRLIESLPQLINSLTGQDMKSYIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP71</accession>
    <name>A0A0R3WP71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1618 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2546</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001192">
        <property type="protein sequence ID" value="VDM20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP71"/>
    <dbReference type="STRING" id="6205.A0A0R3WP71"/>
    <dbReference type="WBParaSite" id="TTAC_0000255901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000255901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000255901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000255901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30337" checksum="3FDB155C0AD2CAAC" modified="2016-01-20" version="1">MNPPFIAFTSRGKFCHVDGFEATCTYFKIGPLTGDSGERVLLLPTNVNVKNIYLCDKSVNSVPCPALYEVPEESVQWITVPGDDKTTGEARILFVVGFDKDSLDRGPVDVAGASLVVHLIHRAEGSLMFDLINNVDARQLRWDGMGSRGVMSLPRNRSRGAFFRIPLSFDDFYFGPALPAPFIRIEPGSCPPESNLVGLIIFALPWDHQVYHHRFNPRIAATFDLQTISPLPEVYRNLTTPFVDVIIDPRCDNTEVYFSYAYSHWIYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPU2</accession>
    <name>A0A0R3WPU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2767</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001488">
        <property type="protein sequence ID" value="VDM21110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000278201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000278201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000278201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000278201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15465" checksum="486B5BE03C49B03E" modified="2016-01-20" version="1">MQNQHEEIAEYQRKELRLSDCVLYGQSLSVLLQRQDNARRELGASLRLLTPQHTLAIVIVDDVEGRERSGMDLFVEYAKKLGFGTEAPLTTAPMNWRIWHVKDGSLHPTDRRDIFEWLCQDVIWRRMQESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ48</accession>
    <name>A0A0R3WQ48_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2873</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="UYWX01001618">
        <property type="protein sequence ID" value="VDM21386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ48"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ48"/>
    <dbReference type="WBParaSite" id="TTAC_0000288801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000288801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000288801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000288801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45426" checksum="DB817A7106D8CD2F" modified="2016-01-20" version="1">MSPQVLCKQTEKSEKVYEKEAKYGAHNYHPIEVVLCRGEGPYVWDIEGNKYLDFLSAYTAVSQGHCHPRIVKALVDQAQQLTLVSRAFYTDLLGEYEEYITKLFGYDKVLPMNTGGETAIKLARKWGYKVKKIPRNEAIVIFAEGNFWGRTLAACSSSTDPSCYSDYGPFMPGFEIVPYDDIPALEEKLKNPNVAAFMVEPIQGEAGVRVPSDGYLRKVRELCTKYNVLWISDEVQTGLGRTGRRLCADYEDVKADIVILGKALSGGLLPVSAVLANDDVMLTIMPGEHGSTYGGNPLACRVAMAALQVMEDEHLAQHADAMGKIFRESMETLPKSVVSCVRGKGLLNAVVVNEKFDAMEISLKLRDHGILAKPTRRSIIRFAPALVISEEDLKKGCEIIHKVFAMFADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQA2</accession>
    <name>A0A0R3WQA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2927</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001691">
        <property type="protein sequence ID" value="VDM21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQA2"/>
    <dbReference type="STRING" id="6205.A0A0R3WQA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000294201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000294201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000294201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000012">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000294201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="758" mass="81177" checksum="43281974B44C9501" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQJ6</accession>
    <name>A0A0R3WQJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3021</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001812">
        <property type="protein sequence ID" value="VDM21764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQJ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000303601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000303601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000303601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43807at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000303601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30297" checksum="1792A3BC6F820AC6" modified="2016-01-20" version="1">MEALSLPITSTTLLLLSDDEALNEVFTDSFDEIVPEEMGIDVANSEDIEERSVTVMDEEQGVNFPPWKVQRLMLDFNNLSIDADITTVEARLWLGLGSVSFFDPDDIEEESLDDADTDSNCSDASFDNPAFLISLRFGGDTLPGQPQSLSSLYDGWLAVQVKMLQETTLYPVPTAWEVVEALLGHLTSRGGVRACNRVITMGPGAGLMPIRNPPQILDLTFCLEKGHLFLDLTAKPRRWWRRSRRDSTLVQKQSNAPIRKVPPFIAIRHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR91</accession>
    <name>A0A0R3WR91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mab-21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3266</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002155">
        <property type="protein sequence ID" value="VDM22277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR91"/>
    <dbReference type="STRING" id="6205.A0A0R3WR91"/>
    <dbReference type="WBParaSite" id="TTAC_0000328101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000328101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000328101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF70">
        <property type="entry name" value="PROTEIN MAB-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="4">
        <location>
            <begin position="299"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM22277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000328101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46855" checksum="5A67F75181DB3010" modified="2016-01-20" version="1">MSAYTPGDLASSNYRQHEEAPPGQPKYMATIFQSMKSFIHSQVEAHRNGIARNLHEVVQIAQDILREVELQEPRFINTLKTTVDGGRGNNGVSSGLAQKYGLEMDLYEGLRVSSSTEFEVILFLNQMGVFNFVDDGSVPGGAVLKLSDGRKRSMSLWVEFITASGYLSARKIRARFHSLVAQAIEKSAYRGILQLVSGTNSEVKIRVRDRYTLQITPAFRCQGLWPRSANHWPSTASTGWLVWPCPRLATEVKHEGFTLLSQESAFARSDKQQQASAEGDAWQLDFYEAEERLLSQGSRQLCLSILTTLLERHLVLNETRMLHDYLIKTLLLHECEKHPREDEWNEYALPDRINGILLQLISCLQHRHCPHYFLPQLDLFAQHSAPMLELAARRCWTLLRSLITCPTAFQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRT9</accession>
    <name>A0A0R3WRT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Parafibromin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3464</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002472">
        <property type="protein sequence ID" value="VDM22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRT9"/>
    <dbReference type="STRING" id="6205.A0A0R3WRT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000347901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000347901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000347901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000002">
        <property type="entry name" value="protein CDC73 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032041">
        <property type="entry name" value="Cdc73_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16050">
        <property type="entry name" value="CDC73_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="8">
        <location>
            <begin position="271"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="7">
        <location>
            <begin position="488"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000347901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="650" mass="71604" checksum="3783DF5F5A3E38F0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS95</accession>
    <name>A0A0R3WS95_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrous sheath-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3617</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002747">
        <property type="protein sequence ID" value="VDM22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS95"/>
    <dbReference type="WBParaSite" id="TTAC_0000363501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000363501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000363501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274141at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000363501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="832" mass="90345" checksum="B3DE5F04910E8E7B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSB7</accession>
    <name>A0A0R3WSB7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3641</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002790">
        <property type="protein sequence ID" value="VDM23050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSB7"/>
    <dbReference type="STRING" id="6205.A0A0R3WSB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000365701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000365701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000365701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="uDENN" evidence="1">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000365701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25410" checksum="E91151182ACFE5B2" modified="2016-01-20" version="1">MGDDMHICYKKSFVKRYIATYQPEVLMWYHVPSPPISSSMSTDEMANQPIFNTVDIATLSNFCLPWGATIESWSVDQNPPGSVFFTFVVTNAAYQKFHGSALTFYEPYDVSLLDRDRCYRLDVDPELVRIEEAEGEERRRQRTAAVVVREAEAELFTHEELLDIEQRQGVFASSRIGDRVLGVTKTLCLVSRFNFGNALKPFLDFLHSRCFSSKGQSIPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSX5</accession>
    <name>A0A0R3WSX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3850</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003150">
        <property type="protein sequence ID" value="VDM23563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSX5"/>
    <dbReference type="STRING" id="6205.A0A0R3WSX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000386501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000386501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000386501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM23563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000386501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21997" checksum="640D043A0943409A" modified="2016-01-20" version="1">CPKTSINETSNDGCESSHAGVDFLTPSTQNPHSLFTKQHRVSLHPGTGNPKHRSPLLRDRAYSVTVAHLQNKTTRSSLPFFSKQRLSIALHLKRPGIKRSNEAKAIRTLGVIMGVFCICWLPFFIVALGRPLYNYIHNTEKDIDPRLSCFFLWLASVCLLTITQMHVIMTKLRSQLSDRSTFITRRVTGLPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSY8</accession>
    <name>A0A0R3WSY8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003183">
        <property type="protein sequence ID" value="VDM23612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSY8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSY8"/>
    <dbReference type="WBParaSite" id="TTAC_0000387801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000387801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000387801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279348at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000387801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11627" checksum="98CC324364D4C550" modified="2016-01-20" version="1">MRDRVRELEYGLSLRDALFPAPEIPGHLQYLAPDAWAKVAEVKAALTEVEILIGAAAHCIYSVTGPSRPPTFSDRDFAVEMASFARFYSSFKASEWMPAEGFSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT43</accession>
    <name>A0A0R3WT43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Reticulon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3918</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003291">
        <property type="protein sequence ID" value="VDM23761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT43"/>
    <dbReference type="WBParaSite" id="TTAC_0000393301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000393301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000393301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM23761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000393301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20421" checksum="3EFBE75A1AC213B9" modified="2016-01-20" version="1">MVGGATRAAVTQHQALVGNMADVAAKDGSQETLSNFVALLVNLILLTMVTGNLFLIWLLFTLLTPIHLYANWRAVRCLEFTTLNRTRFSILIQDWLRKHNEQSDQLPPLLSVHEVNQREPILRSLWSDSRNRSIHLGCSFEKLTCVVRDCKLLSLLGVFAEERYILYCPEWKKVGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT46</accession>
    <name>A0A0R3WT46_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS3921</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01003294">
        <property type="protein sequence ID" value="VDM23768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT46"/>
    <dbReference type="STRING" id="6205.A0A0R3WT46"/>
    <dbReference type="WBParaSite" id="TTAC_0000393601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000393601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000393601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM23768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000393601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24058" checksum="1F07E78118BA45C3" modified="2016-01-20" version="1">GDFASYWEDVRFIAISGKRKCGKDYFATILRNEVQERLGQTASIIHISGPIKRAFAEEHHLELQELMSSSAYKEDFRRQMVRWGEALRRKDPTVFCRKSLEYLIKDSFFKPAFVIVADCRRPTDLEYFSSLNRDFPLLHLRVSASPVTRRARGWIYTSGIDDAETECALDKAPFDVLVVNESQRTLNLSMALVRRALSDNPLRKMMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTL2</accession>
    <name>A0A0R3WTL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4087</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003636">
        <property type="protein sequence ID" value="VDM24147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000410201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000410201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000410201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000410201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23581" checksum="485F1AECE351B060" modified="2016-01-20" version="1">MAEGSTSSDESSSKHSGATVTEASVQEGLSHLPLFPMSVCDWVIQQQLYTDKSQAAQDPVAVAKKLPNEKADAEKVSSSLDTDSQEETLDAKDVDLTTLAIASSSSDTTGSSSKQQSADPCNLYVNKLPDELGERALFNLFRSYGRVLSVKIYIDLEANKSKGYGTNYSKRQAFFVIRFCALCRSTERSMCYQGHAWSEAGQKKIKRKTCKMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTV7</accession>
    <name>A0A0R3WTV7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003853">
        <property type="protein sequence ID" value="VDM24370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTV7"/>
    <dbReference type="WBParaSite" id="TTAC_0000419701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000419701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000419701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000419701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16473" checksum="A769D027B32E0E2F" modified="2016-01-20" version="1">MMEDCAIVAIKESPSYNTSRRPTVNGPRGAVAYTMLHRPSSSCAIADNLSLCQGTLSPSESLFSADRVSVTSFNGVNSSTASVAQSRSMQNIHRYLNEDVMPNPMKQLQQLAGTPRTRRSNLYNGESLSPVVLTAHSSGPSLSFIHLPVNSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTZ1</accession>
    <name>A0A0R3WTZ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4216</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003933">
        <property type="protein sequence ID" value="VDM24450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTZ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTZ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000423101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000423101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000423101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419455at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000138">
        <property type="entry name" value="Phosphorylase b kinase gamma catalytic chain, liver/testis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000423101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34420" checksum="15677D9F7CDC8E53" modified="2016-01-20" version="1">MAVLDLEKEVVDTSPTNKFNTKYIPQEVLGTGASSTVRRCISKDTKEEFAVKILDLNSGVETIEVLRAECMREVSILRKVAGHPNIIKLQDVFEEDAYVFLVFELCKGGELFDYLTKMITLSEKRTRMIMRQMLDAVNFIHSKGVVHRDLKPENILMDSEMNIKISDFGLAVYATDVDELQETRGTPGYLAPEVLRCGYYDGQAPYGQPVDVWACGVIMYTLLVGFPPFWNRKEYLMLRQIMQGKYSFRSPEWDEISDTAKDLVCFCHSLCSSLPQASFCNCYLGALVFMHAFGFFLHKSIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU22</accession>
    <name>A0A0R3WU22_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4249</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004002">
        <property type="protein sequence ID" value="VDM24519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU22"/>
    <dbReference type="WBParaSite" id="TTAC_0000426201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000426201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000426201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10418135at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000426201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16202" checksum="37450300B53096C4" modified="2016-01-20" version="1">MNIHEVDTSDIDVRTTDDSSSSASSSHTSTETPTETLPAPPTLLTSRRQRRLTRHRGRAAVGRHSDVPPANRAASAAVRQTLAPAAVADSTQMESRAALLAEVSAQRRYVRRGGEVMSRPPHDRKHTKWIYGGGRIGAPHQRVRVRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUC2</accession>
    <name>A0A0R3WUC2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4348</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004198">
        <property type="protein sequence ID" value="VDM24721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUC2"/>
    <dbReference type="STRING" id="6205.A0A0R3WUC2"/>
    <dbReference type="WBParaSite" id="TTAC_0000436201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000436201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000436201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000436201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13808" checksum="1F738E650CBD8DC7" modified="2016-01-20" version="1">MAARNDGIQLLLQAEKKAADKVSEAKRRKVKRLQEAKAEAATEIGIEKKERERRYKLREDEVFGRHSNTEAEIAAVTQKTLDMQAESVERNRGAAIQSLLDQVLVVDPQVHINYRPQQKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVL2</accession>
    <name>A0A0R3WVL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion_trans_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4786</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005327">
        <property type="protein sequence ID" value="VDM25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000480201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000480201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000480201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282292at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ion transport N-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000480201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16993" checksum="41D8FCCFDC1AF18E" modified="2016-01-20" version="1">MSTDEDSIQTSGPLSTQATSSVKRSNYKDFHLNRASKVWEDRFLGNSTACHFARHRTASQVIGKRHSFAGRHISSRFTSSESIPTNLLKSRSQIGSSLSSIKEHLFTMIAPDDNKLCLKFFGTKRAVHLEQQRMFNQQVWIIHPYSCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW03</accession>
    <name>A0A0R3WW03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4927</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005686">
        <property type="protein sequence ID" value="VDM25895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW03"/>
    <dbReference type="STRING" id="6205.A0A0R3WW03"/>
    <dbReference type="WBParaSite" id="TTAC_0000494301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000494301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000494301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM25895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000494301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17364" checksum="4FA7086865DB8040" modified="2016-01-20" version="1">MGACFGAPIGGVLFSLEVASYYFPAKTLFRSFFCALAAAYVARALNPFGEEHLILLSVDHDTTWHFVELVPFAALGVCGGIFGALVVCCNKAVQKFRRKRCAERPITYLLVLTAVFSFTAYLHPDLRAEEKLFIRKLVSSCTAGDQEDLWWALSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW27</accession>
    <name>A0A0R3WW27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4952</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005755">
        <property type="protein sequence ID" value="VDM25940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW27"/>
    <dbReference type="WBParaSite" id="TTAC_0000496701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000496701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000496701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10367561at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000496701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15266" checksum="A7798ACD0B85F3A7" modified="2016-01-20" version="1">MSVRVHKFYVIYLNAGSYEVDLMRIASDLTDSVVASAIVQVMSGCFRGSELVTATDSGISFVEIPGHLSSGEDDELTVTGSKPHLAPTPAEAGTPIIPFSDLDKLGPVQTSSSIGVSVGRNDSQKSTTSSGYLGSGDEFVPHDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW77</accession>
    <name>A0A0R3WW77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5002</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005931">
        <property type="protein sequence ID" value="VDM26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW77"/>
    <dbReference type="STRING" id="6205.A0A0R3WW77"/>
    <dbReference type="WBParaSite" id="TTAC_0000501701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000501701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000501701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6237826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000501701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17757" checksum="F10C7F7507C9318A" modified="2016-01-20" version="1">MEVEDVLDQIEKVDTDSNGYVTRAELEKYFKSTNQDLAIVDNWFRWFDLENKGVIEAEDVCTTLGVPMREPYAQRVKANRERKKKTTVVSDLRSKRLIDKISDSSGHSMMSGSKSNGVKEPMSRRQGSTTSSSSSGVKVGRVTNVSRDESVDNRKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWS6</accession>
    <name>A0A0R3WWS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rad21_Rec8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006562">
        <property type="protein sequence ID" value="VDM26456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWS6"/>
    <dbReference type="STRING" id="6205.A0A0R3WWS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000521601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000521601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000521601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10631749at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000521601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10938" checksum="4F3C314923D441EA" modified="2016-01-20" version="1">SHVSKRTIAEVGLSDDENTNGNCIGGGSRGNAGVGGVIYSKMNEGDDDNGNEEDDDDGAQSEGTTIAAVGSRETGKRSKFTFRRSIMERFQRCGIDFTTFAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX83</accession>
    <name>A0A0R3WX83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5360</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007182">
        <property type="protein sequence ID" value="VDM26797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX83"/>
    <dbReference type="STRING" id="6205.A0A0R3WX83"/>
    <dbReference type="WBParaSite" id="TTAC_0000537301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000537301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000537301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAPS C2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000537301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12553" checksum="F4CCD002A1B0E69A" modified="2016-01-20" version="1">MKGSKYFFSRRLALTPVRYFVVSVFCKVVLNPTCTGSRAPEWYKMQTSRNCPDDLRIQLTIRMDKPSNLKYCGYCYAVGRNAFKKWRKRYICLIQASDVLLPLLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXU0</accession>
    <name>A0A0R3WXU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008013">
        <property type="protein sequence ID" value="VDM27236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WXU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000558001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000558001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000558001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000558001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11227" checksum="E1AB41C9E0911BBA" modified="2016-01-20" version="1">MRVEGGGAYGHPMVVSTRASSAFPLILTKMFDDETMLQRVPKCLYIVGGIMAGLQLLGCIFVRPRPEEGGTNELAVHHSAGLNLHSLSVSSTQPPRAITWFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXV0</accession>
    <name>A0A0R3WXV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008057">
        <property type="protein sequence ID" value="VDM27257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXV0"/>
    <dbReference type="WBParaSite" id="TTAC_0000559001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000559001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000559001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133044" evidence="1">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000559001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="11899" checksum="FBAAB26797272A92" modified="2016-01-20" version="1">MSLLISFTLRLLLLLLSLVLITQTACAHFLPSSPSTLSALTSSLSTEEVSLLDYRVGAQLATEQASCSPTHFNASLMPLTYAAATVASPLEGIGRGLTATKACTWVWRDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY96</accession>
    <name>A0A0R3WY96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008733">
        <property type="protein sequence ID" value="VDM27523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY96"/>
    <dbReference type="WBParaSite" id="TTAC_0000573601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000573601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000573601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6228263at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000573601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17087" checksum="D010FA8A02C3EC09" modified="2016-01-20" version="1">MTANLSIMAASPGPGKPFPLTRKANNPGFGQQSSRAPNTFQLAPVKGYAFATHCGEIRNIIRSTLDEALVDSQSDLQQTLMDALGKIKSELLQIQALFFPRHRLVVHGIIGGVVHNQPSIIYGSQCLGEHECGDDGVSVSVRSHDKFICVSAYGFYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYB3</accession>
    <name>A0A0R3WYB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyr_redox_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5736</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008815">
        <property type="protein sequence ID" value="VDM27561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYB3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000575301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000575301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000575301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000575301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="31507" checksum="47DB1CD8BC8065E4" modified="2016-01-20" version="1">MVGLTAGDPHYDAKIALVGCGPASISCATFLARLGYRNVHIFERGERIGGLSTTEIPQFRLPGAAVAFELQMLRDLGVRIFTGRPFSASAAEASDSVRKPHGVTLDSLRASGYRAIFLGFGLPNPHSTGVFAGLTSQQGFLTSKDFLPCVSAASKGCLGCDNARLPDLKGKRVVVLGAGDTAFDCATSALRCGASRVTVSFRKSFTTINPVPEEMELAWQEKCEFLPNLVPNEVHLGGDGRISELSFVRRERNDDGSWHTDPEQVVKLKTDVIITAYGAELDDVDVLSAMKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYC5</accession>
    <name>A0A0R3WYC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5750</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008885">
        <property type="protein sequence ID" value="VDM27594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYC5"/>
    <dbReference type="STRING" id="6205.A0A0R3WYC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000576501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000576501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000576501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000576501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17591" checksum="C1716391D6F49E9B" modified="2016-01-20" version="1">MVGPPGTGKTLLAKAVATECGTTFFNVSSSSLTSKWRGESEKLVRILFDMARFYAPSTIFIDEIDSLCSRRGGESEHEASRRVKSELLVQMDGVNGATGQDDDPTKTVMVLAATNFPWDIDEALRRRLEKRIYIPLPSGLESVQHHETAVVLLIYKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYF1</accession>
    <name>A0A0R3WYF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5776</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008999">
        <property type="protein sequence ID" value="VDM27648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYF1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000579101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000579101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000579101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000579101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9446" checksum="4D2E9AA8D9CF8872" modified="2016-01-20" version="1">MMNTGRGDQQSQMVQRVIARFDFNASEPEELSFHRGDVIEVLGQEDENWWRGRISSTGSTGLFPANYVDTLPPIMPNAAHRPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYG1</accession>
    <name>A0A0R3WYG1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRF-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5786</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009052">
        <property type="protein sequence ID" value="VDM27667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYG1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYG1"/>
    <dbReference type="WBParaSite" id="TTAC_0000580101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000580101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000580101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10621194at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="Zn_ribbon_Top1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA topoisomerase type IA zn finger" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="DNA topoisomerase type IA zn finger" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000580101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20364" checksum="DA8C90FA5A7B4BB9" modified="2016-01-20" version="1">MGAYQKLCSCPSCGKDVVIRRKSPQDLNNFGVSTRPSSNRSRWFVSCTGFPDCKFSIWLPDGVIAARVVMPVSQGVTGRTPTVPCMSVDGGSCLGGGRLVGLKFRLGTVLPCGYVQEDPEMEYVTCLFCDEEFRMAFDIRIAPVTTASPPVPRPVLSEQQRPTSSVTLHQPNRGFSTVVPSTQVDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0U3</accession>
    <name>A0A0R3X0U3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipocalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6764</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0U3"/>
    <dbReference type="WBParaSite" id="TTAC_0000677901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000677901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000677901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6225367at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000677901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30228" checksum="E87DC0FEDF81B652" modified="2016-01-20" version="1">MQRTNEYFSITICVLIWTIDISGKIVTVGSSEWGTLCKLNVSDFHPESIGKQNRLLSLFPGLHSLYTWYKPTHRPCCFPQTWESEFIVHTRRIGRRPRSDRCLYRIRRNSTNPPTIEAVMVIGQTVLSNRLCEEWRGPHLKVCPKDEKECLHMPYLGEPRCISEENGFHYVPVSEALQRELWFTDARIPTGGVKRHLYTFSRKYEVCRLERYQVLVGQYVDSKSDCRMMFLMDQLFIPSPGTFNANFEQDILDGMFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0U7</accession>
    <name>A0A0R3X0U7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GuKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6768</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0U7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0U7"/>
    <dbReference type="WBParaSite" id="TTAC_0000678301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000678301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000678301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase/L-type calcium channel beta subunit" evidence="3">
        <location>
            <begin position="234"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000678301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="786" mass="84721" checksum="ED9C5261EA20D998" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0V4</accession>
    <name>A0A0R3X0V4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Programmed cell death 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6775</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-03" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020322">
        <property type="protein sequence ID" value="VDM31041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X0V4"/>
    <dbReference type="WBParaSite" id="TTAC_0000679001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000679001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000679001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="706"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000679001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1672" mass="184121" checksum="A4521330D7EC94F0" modified="2016-06-08" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X125</accession>
    <name>A0A0R3X125_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6855</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020327">
        <property type="protein sequence ID" value="VDM31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X125"/>
    <dbReference type="WBParaSite" id="TTAC_0000687001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000687001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000687001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000687001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8511" checksum="9383228FAF1075D4" modified="2016-01-20" version="1">MVILVAVKEEEEEEEVKATVLRHCCHVTQKEARAYVRERVCFRCVVQRGAAPHYTPSLRSSFTLPLPLTQGREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X149</accession>
    <name>A0A0R3X149_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc/cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6882</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020328">
        <property type="protein sequence ID" value="VDM31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X149"/>
    <dbReference type="STRING" id="6205.A0A0R3X149"/>
    <dbReference type="WBParaSite" id="TTAC_0000689701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000689701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000689701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29444at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="38"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000689701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="684" mass="76260" checksum="9D17DF4036644004" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Y7</accession>
    <name>A0A0R3X1Y7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fructose-1,6-bisphosphatase isozyme 2</fullName>
            <ecNumber evidence="8">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">D-fructose-1,6-bisphosphate 1-phosphohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Muscle FBPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TTAC_LOCUS7243</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
            <location evidence="4">Sarcomere</location>
            <location evidence="4">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 24">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020356">
        <property type="protein sequence ID" value="VDM31593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Y7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Y7"/>
    <dbReference type="WBParaSite" id="TTAC_0000725801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000725801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000725801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000005">
        <property type="entry name" value="Fructose-1,6-bisphosphatase isozyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="17 24" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="25">
        <location>
            <begin position="11"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="26">
        <location>
            <begin position="205"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="VDM31593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000725801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37271" checksum="C465065F97FB284B" modified="2016-01-20" version="1">MTSNQIDTNCMTLTRFIINEQMKYPGASGELTQLMNGIQTAVKAISNAVRKAGIAELYGFTGCSNIQGEEVKKLDVISNELFINMMVSSYTTCMLVSEENEEPVIVEAKQQGKYIVAFDPLDGSSNIDCLGSVGSIFTVFRRKRQDHSAATAAEALQSGRNTVAAGYAIYGSSTMIVLSMGSGVHGFTLDPSLGEFILTSPNITIPTRGKIYSVNEGYASYWSKGMTNYIHAKKFPKNGKPYVGRYIGSMVADVHRTLLYGGIFLYPDLSVAPEGKLRLLYECIPMAYIIEQAGGKAMAREGLKILDIKPTHIHQRAPIYLGSPEDVDEVIHFLAEAGKGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X236</accession>
    <name>A0A0R3X236_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Usp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020361">
        <property type="protein sequence ID" value="VDM31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X236"/>
    <dbReference type="STRING" id="6205.A0A0R3X236"/>
    <dbReference type="WBParaSite" id="TTAC_0000732501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000732501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000732501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000732501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16583" checksum="CFBCCBC2812ED043" modified="2016-01-20" version="1">MPVDGSSNSHRAFNWFLKYDYRKSDFIIFLHVLQSKSSSSCNTVMALDNLVNIPVQSDSEPVSNGDAVLEKFRKLAEQAGVNFTVEALNDSSVAEAILRLASDLDANFIVVGSRGVSGVRRATLGSVSHYLVTHSSVPVLVVPSSSSSRSFTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2L2</accession>
    <name>A0A0R3X2L2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7519</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020379">
        <property type="protein sequence ID" value="VDM31913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2L2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2L2"/>
    <dbReference type="WBParaSite" id="TTAC_0000753401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000753401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000753401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008092">
        <property type="entry name" value="Ribosomal_mS29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01716">
        <property type="entry name" value="DEATHASSOCP3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000753401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45009" checksum="9D0DE7946FDE1CD3" modified="2016-01-20" version="1">MNVPLLRSICRLLSTSPSAIPPSSSTWFRNDVPRTDILTPTAQVSNPSACLGRFYSINDHAASHIISPFLTDEHLRELSLFDDFSLLVRKPALDVMGLLESTKLTSSVPRFVLYGQPGCGISVQLAHIAHYAAEKGGIILAFCNAESWLERCSDFIPSGSYHQEQYKNLIEGEALDFPSRSSTWLRSFLKLNSRTLEKLNPTITRSVEWTVNDSTPAGTPWIELIDFALTRPKYSTDCIGILLREMRALSAGERATKCYLIIDGVNFLWCRGTRMQDKVLGKKVAVDRLAIVHHLRRALKGDWPHGGIITSVNERASWPSDRESFTPGYLLTKRGFETMDPFIPVRVFNYTAEEMDAIMHFYAQHKWFANPAALEKDGRAEITFLSDANPRELARVAAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X367</accession>
    <name>A0A0R3X367_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7754</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020401">
        <property type="protein sequence ID" value="VDM32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X367"/>
    <dbReference type="WBParaSite" id="TTAC_0000776901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000776901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000776901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10604051at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000776901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="327" mass="34906" checksum="DD9BC422AC3F059C" modified="2016-01-20" version="1">MATRMLSRAPLDTVLNACHDKVTASNVPSTLHGGQQSPSRKGDEGGTGVSERQLVIDSLQLGGEWLSVRPMAGGISLFKNSDTGLFTRDDSILASSLLLASNSLMSRSSEAPSTSTSTPTTATQLYSQFQNYYHLHENGIFPSSLILHPSNTDTATAADSEGYSTQLPNLTASLLRSRSDSLSRRASEPNLQKFGASADNFSTAAAAAASATANGDMMVRQKNTTEQLVRALHGNLLMERDPSLTSTIASSTAQPPTQTSSEAELYQSPMRGTSQVYDEDTEDVVDDDESTIFVQESNDSRTSNGGEECTTTKNNNEITTQIAMTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3G8</accession>
    <name>A0A0R3X3G8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7879</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-like protein involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020416">
        <property type="protein sequence ID" value="VDM32349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3G8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3G8"/>
    <dbReference type="WBParaSite" id="TTAC_0000789401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000789401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000789401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1 4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000789401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29513" checksum="21BFA611F9BAC64D" modified="2016-06-08" version="2">MAGAAVDTNCAEEGHQTPSKSQNKVDVLLKPVGNAPCVRKSKWKVARSDTLSKMVNSLFALLRLDPQEESIFIFVLSSFAPPLDTEIECKILKDFLFTAISVNLFQMKAYPPQAFKSAFVFGTPAMILLARSVRKYVMEILNSLQLSEVGQQELVLRYHHSENGGCCDVIFRFRCLAFRPDTYLNLDFWKEALGSALGRLWLRPPPIFHDVRKGVSWALMVRNWLQPSSACHKAASGCVKDPSKTYCAHTILFFSLTPSPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Q0</accession>
    <name>A0A0R3X3Q0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7972</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020427">
        <property type="protein sequence ID" value="VDM32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Q0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Q0"/>
    <dbReference type="WBParaSite" id="TTAC_0000798701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000798701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000798701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="103"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="274"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000798701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="380" mass="44434" checksum="1FE3D9068F12BE6E" modified="2016-01-20" version="1">MDYSKWDHIEVSDDEDDTHPNIDTASLFRWRHEARLNRDREWKAEKEKFEKEKKEHIEALQKARSLYEEGVKNNASNVKELEENLKKLEVADKEWQEKEKEMNKKERFINKAALKEKPKVDEDDDDDVHEEAADRLRDFVKKHEAEIKKFGMFSRPVDSQQYLLEKPYLVCDETANHLVLWCLDLAMEEKYSLLDHVSHQCIVMQFMLELAKSLKCDPRSCIRPFFNKFINPEPEYQRMFEEELTAFKARIRDRARVKLTEAMQQYEAEERQKRLGPGGLDPYEVIETLPEPLRKCFETRDVELLKKTLTEMDPKEAEECMKRCIASGLWVENAADAAADVGEGEDKVYGAANGVSVEPEREDTKEVAPANCPDNAPNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Q7</accession>
    <name>A0A0R3X3Q7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7979</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020427">
        <property type="protein sequence ID" value="VDM32460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Q7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Q7"/>
    <dbReference type="WBParaSite" id="TTAC_0000799401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000799401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000799401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="37"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000799401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61319" checksum="D449E0D933EE5624" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X429</accession>
    <name>A0A0R3X429_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8125</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01020451">
        <property type="protein sequence ID" value="VDM32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X429"/>
    <dbReference type="STRING" id="6205.A0A0R3X429"/>
    <dbReference type="WBParaSite" id="TTAC_0000814001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000814001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000814001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
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        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="104"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="369"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000814001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="591" mass="66044" checksum="6CB26B7CD1002111" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4A5</accession>
    <name>A0A0R3X4A5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8216</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020466">
        <property type="protein sequence ID" value="VDM32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4A5"/>
    <dbReference type="WBParaSite" id="TTAC_0000823101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000823101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000823101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274447at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000823101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15432" checksum="AF46D92F9EECB4AF" modified="2016-01-20" version="1">MMDPVAKSFSSKQSASFASISSGNHTSSDSIATNTSGSSSDSGEKTLNSDCTSLYIYTGGQIPRNFFPSDEEEEDWSISENATSGVVHFAHREQILEKPYIATYRLMTALDVWLQEVRVHTELESPTPMISKPLTHSSSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5I2</accession>
    <name>A0A0R3X5I2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCDC34 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8711</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020567">
        <property type="protein sequence ID" value="VDM33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5I2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5I2"/>
    <dbReference type="WBParaSite" id="TTAC_0000872601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000872601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000872601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249602at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045323">
        <property type="entry name" value="CCDC34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025259">
        <property type="entry name" value="CCDC34/181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247">
        <property type="entry name" value="NY-REN-41 ANTIGEN L15 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13904">
        <property type="entry name" value="CCDC34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="2">
        <location>
            <begin position="67"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000872601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27449" checksum="FF279950A658CD75" modified="2016-01-20" version="1">MSIHNFFSAPRTHLVAPYARKTSIKIVQPQGVPTPDLICDESVGPLPTSLEDCIINYVHPPLPQKQLTPWERWMAKKKADRIKATHELAKLKVENETKRLLEDEKRLERKRTERAKVQEWIENKNNEIVKQKKLAGIAKLEQKAEAIKKKAQEARSKEKYQEWLNKKREEEQTERRRCEKERYMRGLAQQEKRRQAEASFQVWLRSHKVSATSVSRRSPHTYCISDGMLVSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U2</accession>
    <name>A0A0R3X5U2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PRORP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8841</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020603">
        <property type="protein sequence ID" value="VDM33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5U2"/>
    <dbReference type="WBParaSite" id="TTAC_0000885601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000885601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000885601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030678">
        <property type="term" value="C:mitochondrial ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="8">
        <location>
            <begin position="273"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000885601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42924" checksum="3D35B336C96B39F4" modified="2016-01-20" version="1">MAGVLRFFRGVTKLCSIRGVSENVCLRYTHFSAAAAMSSFQHIDAYFKLLDNSFLEFSHLQAMYELLESPSIDPYFKMNFWSKFVLTSLACGKDKIVNSLILFILERSDCHSIATLITVLKALALQKRFKEFESLYALVMSRLSPTDVYVYAADVSAALCLTPFYKEARGFLHMNFERKVPIETFGHFLSAAAIYGPLDEVISFIYELHSMGLNPTQDFYPAFIKRLQGDEGMHYMTSLLEAISSCQCILSSSTALLLKDWFENHGWRGTMGVTLTGSNDDAFMIYLALWSGPNCYLFSNDEFRQHRFTLGTDASPLLARWQAARQISMRSTRPLIFLGPALCDPTIQGSMTEGWHIPYESGGQRPSYLPSNTWLCLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X620</accession>
    <name>A0A0R3X620_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8923</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020628">
        <property type="protein sequence ID" value="VDM33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X620"/>
    <dbReference type="STRING" id="6205.A0A0R3X620"/>
    <dbReference type="WBParaSite" id="TTAC_0000893801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000893801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000893801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000893801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="690" mass="75270" checksum="41F6E9B4B9C47B8E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6B6</accession>
    <name>A0A0R3X6B6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9028</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020659">
        <property type="protein sequence ID" value="VDM33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6B6"/>
    <dbReference type="STRING" id="6205.A0A0R3X6B6"/>
    <dbReference type="WBParaSite" id="TTAC_0000904301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000904301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000904301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="11">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="579"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="863"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000904301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="901" mass="96530" checksum="D6B96FE0BCB70338" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6H8</accession>
    <name>A0A0R3X6H8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020679">
        <property type="protein sequence ID" value="VDM33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6H8"/>
    <dbReference type="WBParaSite" id="TTAC_0000911201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000911201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000911201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000911201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48870" checksum="4A19910B42B7331A" modified="2016-01-20" version="1">MVDDCFVSDIENVVRLSSLPCHEEELSTSRWEELALKVRDLLIRSRRNDIKRLPYRSLIRLLIVICGCLGNELSTKKLTKCSKDLVTLAQEILDHFVTSFGVPDVGGLLAMIVPGRSVKATVFDHILLESTQCIARLSTDSSVNSLSMAPLFRDALIWATSMVRFPVLCNGQQLSTLHPLSLQLIGDYRCQLKMLGLRVLLRLAQEVVVAFWRMTGRAEATLETLTCQRSTHSENAQIVELTCSSISALISLLEPAPKKRWYSKFMDNLLCDLALETLLDKKIVLQRYVLTLVDVLGQEVLIHSRRLLKAAELSLLAPRAPPYKGEVHSQEHESFLLQLNTLSKYVRLAADRLSPDIFSMVLPILIAFVDLEWNRKGIDLNALSMENIAHVIVEIVEELAAIDAVILRDTLNMCTELSPSTRSVLYKSTSASSCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6K9</accession>
    <name>A0A0R3X6K9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9132</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020689">
        <property type="protein sequence ID" value="VDM33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6K9"/>
    <dbReference type="STRING" id="6205.A0A0R3X6K9"/>
    <dbReference type="WBParaSite" id="TTAC_0000914701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000914701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000914701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133286" evidence="7">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000914701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37174" checksum="6514B9D691D71C86" modified="2016-01-20" version="1">MGYVIIIVVLLMLQQMHTDSTLLPEGAPLSCPGPQSDSAGRDPACAGCPNQALCASGAPKLSLEEREPEIVAEIRNRLGRVRHCLFVLSGKGGVGKSSVSTCLAWALARQNQCRDQVGLLDLDICGPSIPCLMGCLDSEVHQSASGWSPVFVTDNLALMSVGFLTSPDQALIWRGPQKNSFIRDILCKVTWTDNYADETATSLDYLLIDTPPGTSDEHLSSVPYVKAAGCPVAALIVTTPQEVALSDVRKEINFCEKIGLRIVGVIENMSAVECPNCGFANEIFPRTTGGADSLTGLEVIGRIPLDSRLTRCLDEGQCPFDVIDGLPVTKAFDTLASNIKAKLNQNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6M1</accession>
    <name>A0A0R3X6M1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9145</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020693">
        <property type="protein sequence ID" value="VDM33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6M1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6M1"/>
    <dbReference type="WBParaSite" id="TTAC_0000916001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000916001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000916001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281235at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000916001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1167" mass="120563" checksum="0B88604444BC48DE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6U9</accession>
    <name>A0A0R3X6U9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphate carrier protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9237</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020728">
        <property type="protein sequence ID" value="VDM33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6U9"/>
    <dbReference type="STRING" id="6205.A0A0R3X6U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000925201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000925201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000925201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="149"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="250"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000925201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39157" checksum="E5F833BACF60C3EC" modified="2016-01-20" version="1">SPISYCKFNCLEQLTPFIHVGYSSWFGASSRLFLSLGMTVESETSCEFASPKFYALCGLGGIVSCGTTHTAIVPLDLVKCRLQVDKAKYGSLTRGFRVTLREEGLRGLGRGWAPTFFGYSLQGLGKFGFYEVFKHTYSGMLSEENAFLWRTSVYLAASASAEFFADIMLCPMEALKVRIQTMPGFANTLREGLPKMLAAEGFTGFYKGIVPLWCRQIPYTMMKFACFERTVEALYNYVVPKPRSQCSKPEQLVVTFAAGYIAGVFCAIVSHPPDTIVSKLNKDPNARLLEVAKNLGWRGMWTGLGPRIIMIGTLTALQWFIYDGFKVVMRLPRPPPPVMPESLKAKLAAQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Z1</accession>
    <name>A0A0R3X6Z1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9286</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020748">
        <property type="protein sequence ID" value="VDM34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Z1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Z1"/>
    <dbReference type="WBParaSite" id="TTAC_0000930101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000930101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000930101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="569"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000930101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="750" mass="82653" checksum="91F3ED5C5E16A891" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7V6</accession>
    <name>A0A0R3X7V6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020928">
        <property type="protein sequence ID" value="VDM34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7V6"/>
    <dbReference type="STRING" id="6205.A0A0R3X7V6"/>
    <dbReference type="WBParaSite" id="TTAC_0000963101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000963101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000963101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000963101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24388" checksum="5641018233D245DD" modified="2016-01-20" version="1">MNLFHKEKDLRPKVRDLQTRLRREQRKLDRDIVSIQQKSKQCEVEVKKYAKSGNIDAAKILAKEIVASRKSVNRLYQAKAQINSVIMELENQVAMAKMASALSQSTSVMQAMSKLVKLPELRTTMCNMSKEMMKLGLMNEMMEESIDSALDQPEELEEMAQAEVDKILFELTNGAMGKAPDAVTDTLPAGAQRPSEVADDTLDDLEEMRARLQAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8X0</accession>
    <name>A0A0R3X8X0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9980</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021210">
        <property type="protein sequence ID" value="VDM34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8X0"/>
    <dbReference type="STRING" id="6205.A0A0R3X8X0"/>
    <dbReference type="WBParaSite" id="TTAC_0000999501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000999501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000999501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000999501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7971" checksum="E7C412A6A4D50F9C" modified="2016-01-20" version="1">MGGDVGSLALGRPVIYFIALIDILTRYGMRKRTAQTYKTVKHGGANADQITTVRPEVYGRRLLDFLRNCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X955</accession>
    <name>A0A0R3X955_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10065</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021282">
        <property type="protein sequence ID" value="VDM35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X955"/>
    <dbReference type="STRING" id="6205.A0A0R3X955"/>
    <dbReference type="WBParaSite" id="TTAC_0001008001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001008001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001008001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001008001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12181" checksum="2B84715C3FE63C07" modified="2016-01-20" version="1">MDHGCHQNGIGDGNRRGSDYAFMSSAGGTEAAVRPSAALVQLQSPSLNSRPFVSSVHPQHIEFSSPLDAVCDEDRRFSALFAPRAVAPCASIESLGSYSSPSASSLGLNRHETFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9C3</accession>
    <name>A0A0R3X9C3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10133</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021343">
        <property type="protein sequence ID" value="VDM35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9C3"/>
    <dbReference type="STRING" id="6205.A0A0R3X9C3"/>
    <dbReference type="WBParaSite" id="TTAC_0001014801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001014801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001014801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF49">
        <property type="entry name" value="NIM1 SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001014801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25495" checksum="0065490BC36E9F90" modified="2016-01-20" version="1">MTVLDKLHHPNIIRLYEVIENLTRLNIVMEYAAGGDMETRIQKKGAFTDPEGKIIFAQLVSAIRHMVRDDGLSSSIKSCTMMALTGKLVTLQHDNNIVHRDIKAENVFFAVRSPIVDPEMKETNTNNLSNATAAASTTPTTTRANNVAAPPSVSLFQTRKAGHKVRATHSRISSDDRSTGQGHGQTLAYSPDFYRVKIGDFGFSKTITNADQHLTTFCGSPPYAAPELFSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA37</accession>
    <name>A0A0R3XA37_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF4201 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10397</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021651">
        <property type="protein sequence ID" value="VDM35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA37"/>
    <dbReference type="STRING" id="6205.A0A0R3XA37"/>
    <dbReference type="WBParaSite" id="TTAC_0001041401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001041401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001041401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="535167at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="563"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001041401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="119301" checksum="8E036DEA2A03EBC2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA60</accession>
    <name>A0A0R3XA60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4708 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021675">
        <property type="protein sequence ID" value="VDM35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA60"/>
    <dbReference type="STRING" id="6205.A0A0R3XA60"/>
    <dbReference type="WBParaSite" id="TTAC_0001043701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001043701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001043701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286776at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001043701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="383" mass="41816" checksum="FF84F5A469655D7E" modified="2016-01-20" version="1">MIDGFLECRCVDNVASEEEEMVGQAKGRSTWTINNQVPNPSYVPYGIDGPRISITGASSVLMRYVSLLKTDTSYPLKILYSVHKEFCGYRVHMLMPPPSPLQDIIKGPLATQLVRLNACTMLVSADIALIAPCLSQTVRCTGIMEGLTNDTGKLDRRSITNGEDSGSHSVVLKARPSTMSMEEKNTIITTVSTGSIDRFTSNSNDDVQKVDVEKETVLDVVRKPLSPSMVYCGGPPPTRQNLTLNGATESVVSPHDNVDGESPLDGVNICIAADELPSKKRKSTNRPLNIPRFYPIHKLSSLSAPYQQPIKANQPVHLYVWQMPLAEEVASLIKVNAAYFRYTDQTIGLLFSKPISKPFGCVETGLNLASRPATLAASWLAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAP6</accession>
    <name>A0A0R3XAP6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10606</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021929">
        <property type="protein sequence ID" value="VDM35586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAP6"/>
    <dbReference type="STRING" id="6205.A0A0R3XAP6"/>
    <dbReference type="WBParaSite" id="TTAC_0001062301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001062301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001062301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001062301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15920" checksum="000610047E1BA082" modified="2016-01-20" version="1">MYWPNAMSRKDLTIMPGAVVASECDILGDISVGARTVIHPKARIIAEAGPIRIGESNLIEEQVEIINSIPNTILIIGDFNVFEVGARVHSREVGNSNVFESKCFVGPQVRISNGCVVGAMCSITAPEQLPENTVIFGEGVSRFSFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBH7</accession>
    <name>A0A0R3XBH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022442">
        <property type="protein sequence ID" value="VDM35867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBH7"/>
    <dbReference type="STRING" id="6205.A0A0R3XBH7"/>
    <dbReference type="WBParaSite" id="TTAC_0001090401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001090401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001090401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9987145at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001090401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23976" checksum="808E06E24E4981AA" modified="2016-01-20" version="1">MKQYLQDSVYSKVIRPRIQPSIQPAFVTKSHNKANLLPFAASGSKAARAPAMDLLVPPPPSLPSGQKTPDYLIDILTFYRRPLWDVSKVLDYVKSHNRLHLYIDNYIWDSAVSVVRAVPIPSVFPEKVKVDPEVREFVRELLDFFTHLGNFPPVADARLITSVTAGRDAYVPRDGVVPFDVIFPSAEIRNLPQSGHVSTYVRNYLWNQDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBX0</accession>
    <name>A0A0R3XBX0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pur_ac_phosph_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11030</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022767">
        <property type="protein sequence ID" value="VDM36010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBX0"/>
    <dbReference type="STRING" id="6205.A0A0R3XBX0"/>
    <dbReference type="WBParaSite" id="TTAC_0001104701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001104701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001104701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133324" evidence="1">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001104701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12901" checksum="080A59366FAD9E7F" modified="2016-01-20" version="1">MAMPVILLSILASVIGDNSPEQIHLSLSRDPNAMTVMWTTQQKSSESIVLYGEHEMSMRVFAVQTPFVDGGEEQRVIYMHEATLRDLQPNSTYGNLWRRRHENQICRQIGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC75</accession>
    <name>A0A0R3XC75_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11135</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023037">
        <property type="protein sequence ID" value="VDM36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC75"/>
    <dbReference type="WBParaSite" id="TTAC_0001115201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001115201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001115201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133349" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001115201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13788" checksum="A4CE37775EF352D7" modified="2016-01-20" version="1">MAFLFSLTLLLVACLLATASSPLTTPRRIYSSPSPTGISYHSSGCTAVAPLHTICAVASGAEHIGTLAMKLMAPIKWHIFPPLHNNANEVDRGLCASQGGPYNFIIEVVVVISALTLLIRQRSALTSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCM6</accession>
    <name>A0A0R3XCM6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11286</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01023495">
        <property type="protein sequence ID" value="VDM36266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCM6"/>
    <dbReference type="STRING" id="6205.A0A0R3XCM6"/>
    <dbReference type="WBParaSite" id="TTAC_0001130301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001130301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001130301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF499">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001130301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25516" checksum="C9CAD1F5511421FD" modified="2016-01-20" version="1">MPPQVARGIQVYVKEAALPHSLLRSQLIKHLVGMRQIRRENVNAFAGCCMTPDSFSLVFDYCHRGSLQDVINNRSITFDWDFKLSLMNDMIRGMEFLHSTSLKAHGRLKSTNCVVTCRYALKITDYGIPKIHNLTGRHPSDILQDKLWTAPELLRDEEAGVMGSKAGDVYAFAIILHEVFYQTKPYGVEWTSVEEILERVMAMENPPFRPKVIALTQRRAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCS0</accession>
    <name>A0A0R3XCS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11329</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023673">
        <property type="protein sequence ID" value="VDM36309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCS0"/>
    <dbReference type="WBParaSite" id="TTAC_0001134701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001134701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001134701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001134701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12270" checksum="3EBBCC5E244AE7D1" modified="2016-01-20" version="1">MGGYVGASNDRSRGKQATASLLPPTVSSIAIEQPPSHSIRVLSTVSTFRFNTLPRCSTASRAEVAATRLLSAPSAAAGCYIDSISSGYPNLSLTSPLSCLSFSDLLSNLRHSRHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCX3</accession>
    <name>A0A0R3XCX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helo_like_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11383</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023868">
        <property type="protein sequence ID" value="VDM36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCX3"/>
    <dbReference type="STRING" id="6205.A0A0R3XCX3"/>
    <dbReference type="WBParaSite" id="TTAC_0001140001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001140001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001140001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001140001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22402" checksum="1CA9D9D9940FED3E" modified="2016-01-20" version="1">MDAAQFQCMVDQCGALRRDHGDDSRTAQVNQLFQQNNQLLRACDELIDHFSAVATQSAKWNAACQDFVDFTDRQASTISRFNNSSINAIPTEQCLADLKKVQVELDTSVAKRQLVADETQKLTVTLSRAVHSLDSISVLIPAGSTRVYPSHSFRLSVNYRWHDIVMSAVRSLDSMVKETPNVSCHFEKNAGLINLVVIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDI0</accession>
    <name>A0A0R3XDI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11590</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025364">
        <property type="protein sequence ID" value="VDM37211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XDI0"/>
    <dbReference type="WBParaSite" id="TTAC_0001160701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001160701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001160701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM37211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001160701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20365" checksum="F84DB12969AA5649" modified="2016-01-20" version="1">MEIECNQISKLNFFSXXXXEGTARIMEIESGSIRRGSGGATSLPSRVTRLQQQAQQRVGSPSTVSNNNNNSGSPLTVGSPRTSSPTNSSASSGVTDSYMQNTCFRCRRPLIPPESATLGPGAATPPIVTLTGALAVRLHEACFTCYICRTKLNPQGYYHNLHRLLCPTCVRDGAVESCHNCRRPIGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDS7</accession>
    <name>A0A158RDS7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1468</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0000148101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000148101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_N"/>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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        <property type="entry name" value="RNA_pol_Rpb1_3"/>
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        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
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        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
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        <property type="entry name" value="RPC1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04997">
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    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPOLA_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="245"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000148101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150035" checksum="525DFC6777AFBCC5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE38</accession>
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        <submittedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6558</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020308">
        <property type="protein sequence ID" value="VDM30785.1"/>
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    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE38"/>
    <dbReference type="WBParaSite" id="TTAC_0000657301-mRNA-1">
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        <property type="gene ID" value="TTAC_0000657301"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="11"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043135983" evidence="2">
        <location>
            <begin position="18"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1892"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="490"/>
            <end position="613"/>
        </location>
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    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="631"/>
            <end position="754"/>
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    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="785"/>
            <end position="905"/>
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    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1283"/>
            <end position="1410"/>
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        <location>
            <begin position="1443"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="1621"/>
            <end position="1726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000657301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2022" mass="224825" checksum="1C057E47211521C0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REF5</accession>
    <name>A0A158REF5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7194</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="6205.A0A158REF5"/>
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        <property type="gene ID" value="TTAC_0000720901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028852at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903723">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594:SF1">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000720901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="945" mass="105679" checksum="ADDD807A09151C67" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EAG3</accession>
    <name>A0A3P7EAG3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01000999">
        <property type="protein sequence ID" value="VDM19780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EAG3"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="195"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="513" mass="58066" checksum="097DF197349E76FB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ENA9</accession>
    <name>A0A3P7ENA9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000338">
        <property type="protein sequence ID" value="VDM18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="956"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1319"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1521"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1652"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1740"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1928"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="964"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1369"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1524"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1666"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1740"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1800"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1817"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1864"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1942"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1954"/>
            <end position="1963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1991" mass="213419" checksum="4C4F3DD14C4D4D49" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ENT1</accession>
    <name>A0A3P7ENT1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004297">
        <property type="protein sequence ID" value="VDM24820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ENT1"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29251" checksum="6D2C31DD0FEA82DA" modified="2019-02-13" version="1">MSYQIRVSTKETTAPKRKADIGEDEDAENGIVGKIGIRNSSYPPAPKSLRIIDLAYQSQSDPLAITLNDLSLVSERTSKWEADTHDKSKDASAVDDTFLYDLYAVSTNFDEDIPDDLGDEPPLEGIYEGDSDEFDEKHLYDGEDSDSNSESNWRNDYPDEEDLESSDKHSRDSDLDDNSARVLTHAIIMISLKTLFLLIVCVCLAVSQDAEEEVANDETKEAGDTGNATVDVLNGSETLAAEDSVCELRVSTPLIVGSLILYKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ES16</accession>
    <name>A0A3P7ES16_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005933">
        <property type="protein sequence ID" value="VDM26051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ES16"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="142" mass="16048" checksum="AF992729783C0CE0" modified="2019-02-13" version="1">MAELRRSMPRGVFSLSTVVRLSAQMLDAIEAVHDSGFLHRDIKPSNFAMGRGTGSASRTLYLLDFGLARQYTNAEGEVRPARPVAGFRGTVRYASRNAHANRELGRHDDLWSMFYMLVEFASGQLPWRRLKDKEQVGIHCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EV72</accession>
    <name>A0A3P7EV72_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01003372">
        <property type="protein sequence ID" value="VDM23866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EV72"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM23866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="183" mass="20049" checksum="81170AC404A2AA20" modified="2019-02-13" version="1">MDEAHSIGALGPRGRGVVDYFGLDPADIDIAMGTFTKSFGSAGGYLAGSERLIDYVRTQSYSSIYGGTMPAPVCQQIITSMRIIMGRECPGEGERRLKQLAWNTRYFRAHLHQMGLIVFGNRDSPVIPIILYMPGKLVAFSRMCLERGLGVVIVGFPATALLASRSRFCISAGHTKEMLDKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EY99</accession>
    <name>A0A3P7EY99_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006352">
        <property type="protein sequence ID" value="VDM26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EY99"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="223" mass="23533" checksum="34D673B47716C842" modified="2019-02-13" version="1">MAQVVGEAGFLADVAQASFDQLRCFRDSQARAAGLCAAIGCLHRFVGGLACGQHLSTSVSVLLAVAQDSSAPTVQAWALNALALTAESGGPMFREFVQPSLNLVLRLLLKTPSTVTDIHNSLANLLGALITTLGPDLQSSGGCGGGGKPNMGLCCLLCCSILLEHPDPLLQAEGITNFQRIHVFAPHLVNLSLFAPFLSVSCNKWYCDIVMRNGIGDHFHIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F1K4</accession>
    <name>A0A3P7F1K4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS3483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01002512">
        <property type="protein sequence ID" value="VDM22724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F1K4"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM22724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="174" mass="19374" checksum="7E6C61043428C16F" modified="2019-02-13" version="1">MIDIPGLVILSIGIIIYFFFSSSPYYDEHLVDGYSLTAFGSKTAYKNNGLKSVHPPLLNHGRFVHVNALIRHGTRSPDSKFSKKVEEIRRRLQTALPGVDLSVNSCGKGDKVLLSSGVKEIKDLGRRLRAVVPEEFRQGPNMLVISSETERTIDSAKAFLSTVHIFTFSLQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F417</accession>
    <name>A0A3P7F417_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-ketodihydrosphingosine reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003049">
        <property type="protein sequence ID" value="VDM23369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F417"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23567" checksum="3EE2AB894D3F84E7" modified="2019-02-13" version="1">MAQTFEASPPDVFDRLIRLNYLGAVHVTKVLLPAMLSPLGMGVKKERNASQRRIAFVSSLASLVPIYGFSAYAAAKSAITTFADILQQELEDVGPAVTIIFPPDTDTPGLQAENVGKPATTRAISEAGGLESPAAVAASAMHDVLLGRQRSLLGATGRALSWATAGVSRAQQDCPLPLPPPFVAVIEILLAPIFKVALFGFAYWCRACILWHSRKGRQQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FEK2</accession>
    <name>A0A3P7FEK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020893">
        <property type="protein sequence ID" value="VDM34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FEK2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="79" mass="8576" checksum="51C9ED93C039BB2D" modified="2019-02-13" version="1">MILCSCEAVCLLDRLESGTAKISRHCISAILISLRAEITLALPLAQAGGASPQAHTPKRHAIILRIREQEEARGEEMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FF41</accession>
    <name>A0A3P7FF41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008381">
        <property type="protein sequence ID" value="VDM27379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FF41"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="122" mass="13646" checksum="6D3EF1E50A76A28A" modified="2019-02-13" version="1">MVTSMPAPSLTVRFPHLPPLPPPPPPPLGTATIQASRHSIPSPHLRAVLQHRLVTTTMGRLPIPVASLHELLPPYSKRRIPTALPICSRPVFAWMMALSDDFIWMWGYLLQLLAVHTFQLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G2K0</accession>
    <name>A0A3P7G2K0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021940">
        <property type="protein sequence ID" value="VDM35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G2K0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="99" mass="10706" checksum="A4ECC94762852F91" modified="2019-02-13" version="1">MREQGVLQASSEESIEDLSIDTSISSHCDLDRISGGMGRVSAFFFSLLPFTSALDGLFLVEVVAVTTTCLPLLPGSSGIRVIVFTAQFYIFQSWDGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GER1</accession>
    <name>A0A3P7GER1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2831</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="UYWX01001562">
        <property type="protein sequence ID" value="VDM21278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GER1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="147"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM21278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="335" mass="38249" checksum="8C2112BF80723864" modified="2019-02-13" version="1">MCIAPVYIPKYCILKGCDSLGHVDGLSSCHITLSGCPKYHNGTKEYFRGIRSHGQDLEPFPKATEEVATGEQFIKIHEPCLDGLGSDADILLFRRAQQKLASDKGREVTDHLITLAKLHGIQKDKKPLSSQVFISPLPSATIETPLYTENNIKEIVFGDWEMQTWYGSVFPPSIACLPRIYICEFCLSYVPHLVGYRRHRLRCKRRFPPGNEIYRKDKLSFFEVNGALQKEYCHNLCLLAKLYLKQKTVHEIDRVSAFLFYILTEADESGCHIVGYFSKHKAEEQDLPPATFNNLSCLLVMPHYQRQGFGRMLIEFSTSLCFLNSFLGCLSTFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GWG6</accession>
    <name>A0A3P7GWG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006054">
        <property type="protein sequence ID" value="VDM26142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GWG6"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="VDM26142.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="76" mass="8750" checksum="F97096D32156005C" modified="2019-02-13" version="1">MAEDLLRAANQNSRLTMARTQAGWYLLGACMALGPTAVRPHLPRLILLWRNAFPRSTRELEAEKQRGDAFTWQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H8U9</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS6485</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM30702.1"/>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="391"/>
            <end position="543"/>
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            <begin position="585"/>
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        </location>
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        <location>
            <begin position="964"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
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        </location>
    </feature>
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            <begin position="1225"/>
            <end position="1250"/>
        </location>
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        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="402"/>
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            <begin position="444"/>
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        <location>
            <begin position="515"/>
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            <begin position="599"/>
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            <begin position="656"/>
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        </location>
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        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
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        <location>
            <begin position="1137"/>
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        </location>
    </feature>
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        <location>
            <begin position="1154"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1225"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1342" mass="140123" checksum="071095B06ACAA8D1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="9">ANK_REP_REGION domain-containing protein</fullName>
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        <name evidence="7" type="ORF">TTAC_LOCUS397</name>
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    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16722.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000059801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36015" checksum="1AAB887FF65AEA47" modified="2016-01-20" version="1">MDAVGIETISDEVLALVTDHRPGPSVKRSLFVPNVILSFVGKVPLPKVTLRVKLPHRPPGIDVCVIVKDLKATDYNASNDIWKRKWQASGEKCSSATLTFLPLRELKLCYQSYESRRKLAATFDIFLADDRIVHHLSTNLGKAFYGNARDKVPIPVALDKKGLVKAIDEGLHSCLVLVRGRGTTDSVVIGNTSMSRECIKENIVSVIRGVMGKWPGGLKTLRSIYIRGAGPSVPLYFDNTDIDMDASKTGLCKASVQDSVSMHPQLILPTRTLLEVARSLPITEDRVRSILTKTQRQNKRPLRSMQASKHERTRRLLNTKKALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1 3">Uncharacterized protein</fullName>
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                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000072601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256915at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000072601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18623" checksum="35D695AC4E210E27" modified="2016-01-20" version="1">METLKRHDFRHSDLDRGGMTYHSLPQTCNTAEIRLCDSTDFENQIRNWVPLRDVLQGEGNYGPKALFYTSRDTFVSASAPKRVDLGGGREDPVMAKRLFNLETIKRQEARSLSTALLCLRRERLCQVLRCDSRRDEQHQPCHQASTLSSIISALPPLLPLVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJU7</accession>
    <name>A0A0R3WJU7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS965</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000143">
        <property type="protein sequence ID" value="VDM17243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJU7"/>
    <dbReference type="STRING" id="6205.A0A0R3WJU7"/>
    <dbReference type="WBParaSite" id="TTAC_0000096401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000096401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000096401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132838" evidence="2">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000096401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25521" checksum="F5B36D87D34495FB" modified="2016-01-20" version="1">MFHQLGLILLAIVIFHCNATVAVADTAPENVQLEVIDSYTVRMRWDPPPRPGGRIINYHIFWRLNNSWQQTIIVPPVTNYTFERLKPQQTIAAQISAYTKSGDGDEHTTLHSPSAEVKQIITTVRSTRSYTFNNLKPGTTVRARVSAHSRPDGRGERDFFSPLSSEAEVITPLVKGTQMLCYYEQCNREGQLIDNADIVFVPVDFATVIAIIGCNVWMHHRRVTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJZ5</accession>
    <name>A0A0R3WJZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DFDF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1021</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000157">
        <property type="protein sequence ID" value="VDM17321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WJZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000102001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000102001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000102001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000102001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="655" mass="71454" checksum="919F2A8A0C0D4457" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKS2</accession>
    <name>A0A0R3WKS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spliceosome-associated protein CWC15 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1323</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000261">
        <property type="protein sequence ID" value="VDM17809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKS2"/>
    <dbReference type="STRING" id="6205.A0A0R3WKS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000133601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000133601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000133601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000133601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29438" checksum="ACE8E8C9CF73095E" modified="2016-01-20" version="1">MTTAGRPTWNTAKGGKGKWEGDLSALSKQYSVRDLPSHTKLKYRQEGQGRPEDLQGKDFKKDLEEKERQAATEKSKKGQNHALMPHSGEKRPAISDQDRNIGSSKRPRQPAQTANATSVPTANLDADDPWEEDYTEEDLKAPINNPSPTSGEDDDESDEEDEEALLAELAKIKRERAEEAVQAAAEKKAAEETIRMENILKGNPLLNNNNSSEFKVKRRWDDDVVFKNCARGEVDHSKRGFINDTLRSEFHKKFMRKYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLQ1</accession>
    <name>A0A0R3WLQ1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Growth arrest-specific protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1676</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000441">
        <property type="protein sequence ID" value="VDM18380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000168901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000168901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000168901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="767661at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039308">
        <property type="entry name" value="GAS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025593">
        <property type="entry name" value="GAS8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13851">
        <property type="entry name" value="GAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Growth arrest-specific protein 8" evidence="14">
        <location>
            <begin position="259"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="290"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM18380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000168901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56102" checksum="2FC7EFEC4FB48188" modified="2016-01-20" version="1">MTREELEGHVARLRQELEREREDRNRYQVERDKVSTFWAIAKRQLEIRNAELRVAQEATEIVTEQRERELNAIHLRVRQLEASHASQLAEVKAEMATAVGLAAQEAKANTRHPRLIEVELRKEQADHNELVRRMKLDQEKQLHELRQVFEQQSEAERKVYMEKLRQLEERLDLQRRTEIQIVEDSKNEQISVLIKNHEKDFMDIKNYYRSITANSVNLIDNLKTDRMARQELADSSNGYMALTFIAALSLPSSRFYLRKGQIEELQKNENRIVKENSALVTRNRTLESGLSQSQQACNNLKRALENHERDVRALNIARSQLKKLKKTVSDMKLDNEALLERLQLVEGERDELYNRFASAVEEVKQSCGLKNALLERRMACLGEELEKAKLLRLANARDIGDAGKAAEELEGTLAAKNDQIKSLNYELARACKAYKDLLDVFRRKLEDYGIKQENMGFEVNENVLINGGKMQFGKGPAGLITVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM57</accession>
    <name>A0A0R3WM57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1832</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000541">
        <property type="protein sequence ID" value="VDM18572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM57"/>
    <dbReference type="STRING" id="6205.A0A0R3WM57"/>
    <dbReference type="WBParaSite" id="TTAC_0000184501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000184501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000184501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000184501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17864" checksum="1312DF140D5E8A4B" modified="2016-01-20" version="1">MSTRARRRLMNDFRKIKQDPPPGVYAVPQDDNILRWHAVILGADGTPFADGIFKLVMDFTENYPNLPPTVKFVSKMFHPNVYADGAICLDILQNMWSPSYDIGSILTSIQSLLGDPNPNSPANTIAAELFEENTRVYEMKVREVVEESWKCDDLPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMB5</accession>
    <name>A0A0R3WMB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1890</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000586">
        <property type="protein sequence ID" value="VDM18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMB5"/>
    <dbReference type="STRING" id="6205.A0A0R3WMB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000190301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000190301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000190301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274257at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000190301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50546" checksum="6D1C5BBD5E7762B4" modified="2016-01-20" version="1">MSLASRHSGATQGSNHTNANNASKPTHGKSNRICGSFASLISGRLALPRQLVVQARNALDNTPVSIHLSFSGTIGQGTFGQIEKATLTTPPPSKSVDEKSSSSVTANSSDSTVLSVAVKRVLQDPRYKNRELSIMQKLSRHPNVVKFYYYYFSTSSSASRTRSRNSQQPCEGVCTDMPPNADMDVYLHLVLECFPGSLCELVYMYFQRNMSIPPLTVKLFTYQMLKALAYLHSHQICHRDLKSSNLLVNEQTMVLKLCDFGSAKEMVPGTTNVSYISSRYYRAPELLFGAQMYTCAIDTWGAGCVLAEMLRHQCLFTGADSVDQLVKVIRVLGTPTAEDIASMNPMYESYNFPDVQSCPVKLFFPRHTPADLLALMSKMLVYNPNNRLPPRQGLLDRAFDEIRDLRASGGKLPNGNPLPPHLFDSDPPDFSQSAAGDKISTSVAASSAQSKDSSSKHSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN01</accession>
    <name>A0A0R3WN01_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2126</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01000775">
        <property type="protein sequence ID" value="VDM18969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN01"/>
    <dbReference type="STRING" id="6205.A0A0R3WN01"/>
    <dbReference type="WBParaSite" id="TTAC_0000213901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000213901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000213901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM18969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000213901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56986" checksum="6F51B1C0E35425BB" modified="2016-01-20" version="1">MKTYFCIGIRLILTHGLCVLCCFGGFNCLPCNHLGLKADDVVRNVAFFRTERSKRNVEHPRLSFNVYMDPSFTSLPNGSEIKVVLFRYLRYYKKGSGSLFCALGCKKLKHCGPVTVPSEHLNSCRLPSDINYTELGSPVYSGGFLLYLAAKRTRKCTNANILGYSSHCQQEMITDRPTAGFINFCLSPSDNLYDLSHVGFSPSLYAFFRDYNGIPLTPRQPESGIYKWSERVIRTKVRNWSSAIGTFQRKVHMVVTPTVLRFAREYFSCPYLEGVELENQGDTGVSLSHWEMRILGNELMTATYTNVFRLSNLTLAFLEDTGWYLPNYSLAEHLTWGAQRGCVFSTESCYSYIKADTAPFCLTPQDERSGNLFVCTPGQRMTLAPNVTDSLRMYTYFGNTSRLKYRGKVIPYDYFGKVDLADFCPFVQVCCIRSLKLYKLKFVHETLTNWNNYNLEVYGPNSICLPISPNWILLGRKSTVYEAPVRGAGCYKVNSLAHASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNE8</accession>
    <name>A0A0R3WNE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rapamycin-insensitive companion of mTOR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2273</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000917">
        <property type="protein sequence ID" value="VDM19461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000228601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000228601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000228601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6226668at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000228601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53991" checksum="EAC6A1C1576040CD" modified="2016-01-20" version="1">MFLQVPFECDYTAEVGENRRLEWREPVNIPQDTQTLSRLIDSIHQHGKSGGNVAFMGTMDIITHARTPFLIKSLRRGAILALRRLFLRADPFSKDWNGIGPGLAIFNKLVNSSVEVRSCLLDFWPLILRPLNFVFQKLEELKQKRTRFCNALGFEECGTNRWDERIETFQEQVLPYMISDPRVILQREGAGWITMSDYMRSLELIFLVAPDRTQESVDRICRLNCTINLHHTPIQEIMPYDLQTERETLPGPRLHFFNFLDRFEVGHCVGHGAIQEDIALKAEWDLQAVRLDRFELLGSIEHETVNTGVALRDSNSAKTEGRNEKQPLSNRSATALSFNPREPTSASETDFRDLLTTTAIKVPDRVKHNISRGNGSEKITAKRMEDKSDTWAIALPVSRRLKQDPRQSKWFRKAVKPLINSLCLPESHKEADKIVYAGYETIPNIRTHPLTLNILTIPDKVYRPSSHHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP34</accession>
    <name>A0A0R3WP34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TraB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001158">
        <property type="protein sequence ID" value="VDM20283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP34"/>
    <dbReference type="STRING" id="6205.A0A0R3WP34"/>
    <dbReference type="WBParaSite" id="TTAC_0000252201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48306at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42634" checksum="28FC8043C9D7B9BA" modified="2016-01-20" version="1">MIGDTPLVDTYEANSDSDETEDDYEMDSIGSFLERVQVVRQTPFELPKTVSLIECPNGTKVYLIMGNTLPDVVVVELCRNRSHSMLLSEDDIKRQIRENSLIAYVRNMGVSNGVLQYLLLRFTKYIMDQIGMAPGGEFRAAFQEASRQAHCHLILGDRPIKITLQRAMDALGLWQKTKFFFSLLFDFEEITPEDVEEMKSEDLLEKLIKALAGDYPELTRIILEERDLYLTRSIWEVCGLSTEELGHATDQKREEMGLEDHEEEAGIAVRRRPSHGQKRRDLDERGEASMAVDLLEPEERSHLRQDCCCWCPEWPGSSILPRVVVAVVGIGHVAGIKKAWNHAATIDKAELRRFCNTLIHCLNLESHCYCLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP52</accession>
    <name>A0A0R3WP52_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2529</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001176">
        <property type="protein sequence ID" value="VDM20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP52"/>
    <dbReference type="STRING" id="6205.A0A0R3WP52"/>
    <dbReference type="WBParaSite" id="TTAC_0000254001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000254001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000254001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000254001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13483" checksum="9B4742A4202DF885" modified="2016-01-20" version="1">MLAVCKDYVLTSGKDSVVKLWELSTSRCLISYTGAGTLGLHTHRSNAVFNHTEDYVLFPDEVTKSLCCWDSRNADRQRLLPLSHNGPIRCFVHSPTTAAFLSCSDDNRARFWYKRPISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP53</accession>
    <name>A0A0R3WP53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001176">
        <property type="protein sequence ID" value="VDM20362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP53"/>
    <dbReference type="WBParaSite" id="TTAC_0000254101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000254101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000254101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000254101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="13872" checksum="141A9E53536B5CBB" modified="2016-01-20" version="1">MAGVIFIPSSCPSIRADKTGQMSTQCNSRFSASLKGLHNLPIDSGNGGSLAVEQQGEEVFQETSATLPPRVNPTPERRKVNLYSLRNCGVVAVQLLGSHWSAAQHSSLQLLHAIKCKLCVGVGVGAENEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP64</accession>
    <name>A0A0R3WP64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2539</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001184">
        <property type="protein sequence ID" value="VDM20387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP64"/>
    <dbReference type="STRING" id="6205.A0A0R3WP64"/>
    <dbReference type="WBParaSite" id="TTAC_0000255201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000255201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000255201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282505at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000255201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27342" checksum="A3421163B6AEDDE8" modified="2016-01-20" version="1">MQHSPQKKHSAEEDDVITCEKLQRKIHELELERNRILIEKQVLEENARAEHRLADKLITQTLRRRRSRHSSLRHHLSRRDRSMRSDTESSYASQSSTERRVKRRKGDRRGRLKPASKATEDDSSDNGEICEVSVSDLQPYKPSIYPKVCLIAGDSLHSCRNAANFHAFVYEAYADKAKKRDFQSANIFGIPSVTTLMLQKARLNLQAVERDLVTHAKTPDVDSPDYLEYLKKKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPL3</accession>
    <name>A0A0R3WPL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001379">
        <property type="protein sequence ID" value="VDM20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WPL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000270301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000270301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000270301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6245635at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000270301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1671" mass="186908" checksum="124B0E1EF7C0A08E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPP3</accession>
    <name>A0A0R3WPP3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001426">
        <property type="protein sequence ID" value="VDM20974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPP3"/>
    <dbReference type="STRING" id="6205.A0A0R3WPP3"/>
    <dbReference type="WBParaSite" id="TTAC_0000273301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000273301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000273301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000273301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9383" checksum="03EE496E816F2BF8" modified="2016-01-20" version="1">MQESLVCSAHHPAQQTFLCPSGMHIHIISAFHGPQAALIQSRDALPEGLVPCHPLDLSASSPSSVAVNELIPSFCLLAKDVTKELAAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPW7</accession>
    <name>A0A0R3WPW7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2792</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001513">
        <property type="protein sequence ID" value="VDM21175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPW7"/>
    <dbReference type="WBParaSite" id="TTAC_0000280701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000280701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000280701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241969at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000280701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21013" checksum="B5AB4DBAD6243523" modified="2016-01-20" version="1">MRLKRSAPCFPTISTESDIRERISTRRKMRDVESRLDKILDYELPYASGFKEMRNTLREINDKMAKHRLLVDRYSGLQMNEDNEPVADRVAAKVDELIPRVPALSGVQNPFKPRSDEITSSFDPRLIPGYSTGLCVTPSEGTAELRGRIRNLLCRTRETSRQDAANPHLKPFSTTHRKAEVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ35</accession>
    <name>A0A0R3WQ35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cnd1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2860</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001601">
        <property type="protein sequence ID" value="VDM21342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ35"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ35"/>
    <dbReference type="WBParaSite" id="TTAC_0000287501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000287501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000287501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000287501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43366" checksum="A99B34BABD505806" modified="2016-01-20" version="1">MGTSQKPSASQQNSVDLLEIKDALQSDLASIRANALTTLANKSNPDVTFGSVTAAELILAFCADSDARVRAASLNCLCTWTQYEKHKHDAATNKRKFEWISDHWLQVRQVSLRAIHLLGLRFGQKEIASDAVNLFGCAIENASLDMRSGFKKINPIRRKSIKLVDDAFSRVCDRLQDPSRYVRETAAGLIADLAKFVSEDSLMLTLEKTVMTDRQVKRSSERAVMSGGIDKVALWGTVSNPSPARAKRRGAQLPAGPICVDSISLLSTGALGALINGLEDEFHEVRCATLSTITQIAAHNARFASLCQDILVDMLTDDIQAVRLRAITALQTVGDQVPLVADQVGIVTSALAEDNAMIRQRIYSLLSRCRLISPPCLLSLLDGLLATLCQYPRDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ53</accession>
    <name>A0A0R3WQ53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2878</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001625">
        <property type="protein sequence ID" value="VDM21408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ53"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ53"/>
    <dbReference type="WBParaSite" id="TTAC_0000289301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000289301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000289301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="114"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000289301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36500" checksum="406C072C08E110B0" modified="2016-01-20" version="1">MATAQKLPSKYVKLAKTQLGEDPKNTSAHIESLRRWLSSMPHLTCPDDDDFLLMFLRQSKFVHAKAQAKLDNFCTLSSMKCIGNVAWSSPLDLTSKELDNYLNAGIHLPLDYMDDGKVCIWIRPGVWNPDELSVGQALYYAYKVIFMMALDPRTIIAGTVILVDFTGGTSKHVIKDPNDMKAWSRFMQEAMPLRPRRIIFYNEGKLLDAMMSVMMFYMKDKMKDRMVRCGSDIGKAFEAEPGLRGVLPPDLGGEGKSVQDRIQANKRRFLEFYGKDDPTARIKVDESKRPVTARDFLREYKDYNANVMGASGTYINVGHGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQG4</accession>
    <name>A0A0R3WQG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2989</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001777">
        <property type="protein sequence ID" value="VDM21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000300401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000300401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000300401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448087at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000300401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="561" mass="65585" checksum="C1E139B8CD6DFB54" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQN9</accession>
    <name>A0A0R3WQN9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3064</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01001873">
        <property type="protein sequence ID" value="VDM21873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQN9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000307901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000307901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000307901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="68"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM21873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000307901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24818" checksum="56D132F855AC6E7F" modified="2016-01-20" version="1">MSSDKENTNLNISSAAADDAHDERNYSSSSSSPTFRYQSYLSECLARGGASLIHSSIDLLSEASRLTPCMLGIDEAGRGPVLGPMLYACAVAPLSKKNALKEMGLADSKQLTEERREELLKQMLNENDWIAYTIHAISPMEITEKMLSSQKVSLNVISQNAAIGLIRSAIDQAVNLKEVYVDTVGKAEVYQAYLGSIFPDLKIVVESKADATYPIVSAASIYAKVRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR27</accession>
    <name>A0A0R3WR27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3202</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002061">
        <property type="protein sequence ID" value="VDM22145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR27"/>
    <dbReference type="STRING" id="6205.A0A0R3WR27"/>
    <dbReference type="WBParaSite" id="TTAC_0000321701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000321701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000321701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000321701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12973" checksum="36F54F20FB1B911B" modified="2016-01-20" version="1">MESYDRPDPEEVRRVYRRSWHFTLVAVLSFLTMGGLIIPGVFYIFNFLDITSFTIWIYAVLFALIVSAAVTLFMPLVWEAIHLYRLRQTRTRLQVKQHTVPQPSEVVVGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRW6</accession>
    <name>A0A0R3WRW6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Dynein heavy chain 7, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS3491</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002523">
        <property type="protein sequence ID" value="VDM22741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRW6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRW6"/>
    <dbReference type="WBParaSite" id="TTAC_0000350601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000350601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000350601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF20">
        <property type="entry name" value="LOW QUALITY PROTEIN: DYNEIN BETA CHAIN, CILIARY-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="16">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="15">
        <location>
            <begin position="232"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="14">
        <location>
            <begin position="503"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="719"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000350601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="866" mass="98111" checksum="BEBDC4E0B63E9426" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS35</accession>
    <name>A0A0R3WS35_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3560</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002638">
        <property type="protein sequence ID" value="VDM22873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS35"/>
    <dbReference type="STRING" id="6205.A0A0R3WS35"/>
    <dbReference type="WBParaSite" id="TTAC_0000357501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000357501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000357501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="284"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000357501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69304" checksum="36F071125A19B13D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS76</accession>
    <name>A0A0R3WS76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3601</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002707">
        <property type="protein sequence ID" value="VDM22955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS76"/>
    <dbReference type="WBParaSite" id="TTAC_0000361601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000361601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000361601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132996" evidence="1">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000361601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31106" checksum="733AFBCB2842A307" modified="2016-01-20" version="1">MAVHKRHHFLLLLLPLYGPEVIFGQCAMTCPLAKRHSISLRKHLIGAFPSLLSLSTGLFEISLWFMWFEEPPTWVNSCCALLARCGKIRGGGGCGGDQVMVRLLGLGNDAIHPTRTVVVVAEQHCIRQLSRLGSVVGEEVQITLRVGGTGAVRCKQCIDHTLVSQSILVMECIMHKLQCLQRETSCIVVSSSSSSSSSSSSSVEAKQTVERVEDVRGGKECTHLPNHISFTPSVQPSAHYFPDKSTANVFFPTTYVCTSAYRQPHCEGIKPADSFELDEMLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM0</accession>
    <name>A0A0R3WSM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUPID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002971">
        <property type="protein sequence ID" value="VDM23275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WSM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000376001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19190" checksum="48E60D5EDBB9CA56" modified="2016-01-20" version="1">MNQRLHQLSASSALKEREVQELRKIIDRFRCQALQNDWPPTMENGKNGRNGRKLSQSQEFVKPHHILDSEILQQAGSLSSLVNGPNMITGGTSGTYGEVGRYLLDSSGHGYMLPSYMPIRDSLDRTNKKTGWLRSSINRAFRRSKSRDPPDRIKVTSTSSQDTNFPSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSY1</accession>
    <name>A0A0R3WSY1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type E3 ubiquitin-protein ligase PPIL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CYC4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Probable inactive peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TTAC_LOCUS3856</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1. Interacts with isoform 2 of BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01003166">
        <property type="protein sequence ID" value="VDM23580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSY1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSY1"/>
    <dbReference type="WBParaSite" id="TTAC_0000387101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000387101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000387101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30774at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000018">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="23">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="22">
        <location>
            <begin position="286"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="443"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00059251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078275"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM23580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000387101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59115" checksum="7467CB561436F1A7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTP1</accession>
    <name>A0A0R3WTP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003700">
        <property type="protein sequence ID" value="VDM24215.1"/>
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    <dbReference type="STRING" id="6205.A0A0R3WTP1"/>
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        <property type="protein sequence ID" value="TTAC_0000413101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000413101"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM24215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000413101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39945" checksum="C9AAA3775EAF8AAD" modified="2016-01-20" version="1">MSVDHRDALLWPQNDTFSKEDYSVARAFLDSSNVDGNCKAESHMGCWAGSTPVKDSSPSSTEPTSMLSDKSSCRGTVETKNSENTCFSTDTGDTEHPTSEGSLSPLPPSSQYLIETTNSLSCSLQNAPSDLNTLNSGREVSNHSGVVVSRSRAPQLPLKEQFSQEFPVISSNEYKPASAANDRPPFLDSHSSYYNGSASNRMGFSNVERSSYHIHSQHGCNTCPDCYPDSRKFSTPSLLSDVLGLQKFPNSYQSTYSSSPYCWKSSCRSPGLPTCSQESLEVRRRFALQQMYQSAQANRRLPRSAAREFYQQAQDRARQSHYPYLDPYTHFRGSLSEYTESKKYADYSTGGGRLPYSGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU81</accession>
    <name>A0A0R3WU81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4306</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004117">
        <property type="protein sequence ID" value="VDM24647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3WU81"/>
    <dbReference type="WBParaSite" id="TTAC_0000432101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000432101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000432101"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phospholipid binding"/>
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    </dbReference>
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        <property type="term" value="P:cytoskeleton organization"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of endocytosis"/>
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    </dbReference>
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        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons protein 1"/>
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    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000432101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27444" checksum="4112A3B399138BB1" modified="2016-01-20" version="1">MQPAESDVDNGTNASFWEPHQYSRTVKRAENANKLCSEFALMIQERADIEKAYAANLRKFAARLDMFVRTGLEYGTGNNILSGLAKEAEDNAELHSNIASGLISPVQLGIKNWQKENFHKSSISTTIKEVKNFDSEFENAQKNWYKHYKHVNRCKKEYFHACKVVRSLQVQVQNAKNEPFGTPEQLRKLEDKLRKATSEEQKTRKAYEESLSSLSDVTPRYIEEMTQVSSDALGLLRCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUK7</accession>
    <name>A0A0R3WUK7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4432</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004404">
        <property type="protein sequence ID" value="VDM24926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUK7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUK7"/>
    <dbReference type="WBParaSite" id="TTAC_0000444701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000444701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000444701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000444701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36183" checksum="1BA9AB150C692A78" modified="2016-01-20" version="1">WICVESCPPDSTTHVALNSITTAVEFVCLHTGISHHLPPGTPRKGDECFIFCTSPELLSPQMLTRLSWLSTALLIFCGLLALFVVVYFAYVCSRVVTRRRKSRRGPTADQTHSGLSSMCNQFWMRAVVVEPEEEKNERRLSKSRRNISLRSLPVRSSTVNSDDEQSCLVSPQADAMPDMTTLLIIPEYQLKLGSRVGGGAFGSVYRGIWYKGPISPGFAKKVDNLFAEAAKIESEKPKLVPLDSLVEDNAYASTELEYLTMEEEDEGDTKETQGEEKPVNLEEKTGLKLPTQAEESGTSEQSETFTCVSQECQFHFSEDYEAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUX7</accession>
    <name>A0A0R3WUX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4552</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004740">
        <property type="protein sequence ID" value="VDM25167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUX7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000456701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000456701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000456701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000456701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24000" checksum="6377B78E237F54C8" modified="2016-01-20" version="1">MYQSDVKPTNFLHLASAPPPVTAAMSPESSSTSAAAAYMITASTAASGPKSHFLSPLSADYFQQLRTVPDAWLAQPETSGQPPSSQHHPQQNAWEPLPATTYFSQPQLSPSYTKSRRSQIPPSGSKRSDSGTVTAIGGKAGFRGLRDGREESYGVTNGSGSPRDPGGTLETINGSAATVAVTTKKCRVCGDRAVNHNFGQLTCESCKAFFRRNAHKVGANSLEVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW24</accession>
    <name>A0A0R3WW24_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS4950</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005750">
        <property type="protein sequence ID" value="VDM25935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW24"/>
    <dbReference type="SMR" id="A0A0R3WW24"/>
    <dbReference type="STRING" id="6205.A0A0R3WW24"/>
    <dbReference type="WBParaSite" id="TTAC_0000496401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000496401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000496401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM25935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000496401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14770" checksum="126CD1515D656FC3" modified="2016-01-20" version="1">MQIFVKTLTGKTITLEVEPSDSIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRSLSDYNIQKESTLHLVLRLRGGAMDPTMKAVAMKYKCEKMICRKCYARLHPRATNCRKRKCGHNSNLRPKKKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW39</accession>
    <name>A0A0R3WW39_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4963</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005791">
        <property type="protein sequence ID" value="VDM25961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW39"/>
    <dbReference type="STRING" id="6205.A0A0R3WW39"/>
    <dbReference type="WBParaSite" id="TTAC_0000497901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000497901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000497901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10472579at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000497901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17496" checksum="F57F06926B89CA89" modified="2016-01-20" version="1">MVEVDGHSRSMSPPLSQSVRRPSSSFGSDAFLSRHPNPSSQDLDHEIDRLLDDLTTTCLQQDRSNLIRGGPSGTHHFPRRFSTPYRPRWERNGRSGGGVEVSLPELSAYLKICKPRAFGIKTYRRFYVVLEKTSLLMFKVSDTPSVPFSSSSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW81</accession>
    <name>A0A0R3WW81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5004</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005935">
        <property type="protein sequence ID" value="VDM26053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW81"/>
    <dbReference type="WBParaSite" id="TTAC_0000502101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000502101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000502101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133115" evidence="2">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000502101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11654" checksum="14F9BE8976A518B0" modified="2016-01-20" version="1">MCGLSTARVKLSLLFLLLQQLSPCLSLSLAFISTLPSPLFASVVVVAAAATSDKVRGGMERNVHPTNSSEESKTKTRKKDVRSTSIPQRMATLQAWTQCRAKDFTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWE3</accession>
    <name>A0A0R3WWE3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5068</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006128">
        <property type="protein sequence ID" value="VDM26189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWE3"/>
    <dbReference type="STRING" id="6205.A0A0R3WWE3"/>
    <dbReference type="WBParaSite" id="TTAC_0000508301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000508301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000508301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM26189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000508301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21769" checksum="3C64F8745B09098F" modified="2016-01-20" version="1">MRRLIRRSLAKKIIAIIWIVSALLFIPWAYYFRLSQAPDGIINCREFWPSVTADRAYFLGVVTLLVYTTPLIFMAYCYCSIIFRVWMRVHKAQTTTTTTGTTTVTATSTATNSDESRIITKVPHTRYSPPPMHPPLEPIQGGGGASETSRYVGNQHTEAKRVDSYATLRKTLVKMYVRIFLATNVKEGGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX70</accession>
    <name>A0A0R3WX70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-synt_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5345</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007115">
        <property type="protein sequence ID" value="VDM26759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX70"/>
    <dbReference type="STRING" id="6205.A0A0R3WX70"/>
    <dbReference type="WBParaSite" id="TTAC_0000536001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000536001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000536001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000536001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16781" checksum="5B243B2E55502391" modified="2016-01-20" version="1">MIAYEISSGFYFCLSFLFRKPPHSNDNQAPATTSKSPSTTSTATTSVEKARQREETRLFNESVDALAERLRPVLEAVKAHKFAGPFLAPVTASEAPGYFNIITFPIGKWLFFMFISSLRQNPFASRFEIKLFLIAQALKLNLTELMHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXA1</accession>
    <name>A0A0R3WXA1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane bound O-acyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5375</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01007228">
        <property type="protein sequence ID" value="VDM26833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXA1"/>
    <dbReference type="STRING" id="6205.A0A0R3WXA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000539101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000539101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000539101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000539101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13221" checksum="91217A39B12795EB" modified="2016-01-20" version="1">MLDNWNIGTTRWLRECVYDRVPRRFAVVAVFFVSAFWHGFYPVYYFCFLSAALLTMTGRLCRTRLRPCFIESYWYHRLYDIVTNLAALFSLNYLGMGFFLLDTSLALKLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXI5</accession>
    <name>A0A0R3WXI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007637">
        <property type="protein sequence ID" value="VDM27046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXI5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000547501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000547501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000547501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250244at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating transcription factor 7-interacting protein Fn3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000547501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="39" mass="4587" checksum="68E0430EC1DB217B" modified="2016-01-20" version="1">MACTLTSVQPENIYYFAVRSIDRFQRFSEWSNVVDVQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXJ0</accession>
    <name>A0A0R3WXJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5464</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007645">
        <property type="protein sequence ID" value="VDM27050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXJ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WXJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000548001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000548001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000548001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000548001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19401" checksum="A5BEF2A39C546938" modified="2016-01-20" version="1">MERTNHRSGLNKSCLQQPLATTNQRSKVASNQSPAKTTPASTLTNEKSEADPYAWVEEEEEEEVKPEPEPKPSVFAVKEEDEEDDGIKPWFWPASRDIVKPTPSVAAPPHPSHPLSTDGRVSSKDVPLLSPLANGTGVEAKITNNVSMEKKDVSYYLRRVEDTSTDTTFDFCDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXK5</accession>
    <name>A0A0R3WXK5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5480</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01007688">
        <property type="protein sequence ID" value="VDM27069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXK5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXK5"/>
    <dbReference type="WBParaSite" id="TTAC_0000549501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000549501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000549501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM27069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000549501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="28809" checksum="94BE1A7504FD6C72" modified="2016-01-20" version="1">MRAYAPVTVSALQVWFQNRRAKWKKRKKTSGGGGGGGGSGSGNGGVGGVSCGGSGGGGGGGGGSVNPNVTSAFKTPSLTMNSLARGLESAQNIFVKASQQPSTPPSLSLLHAACSRAAAQLSPDHLGVYNPPPSSSSSNRMSPYSTASMPAGGGGSGASTVYSVPLFVHNYPALRILSDAIMNETISGAYCMEDLTHSVMFKQAMLTSSAHSVGGNPPSSQSRESSSPPPPPPPPLPLPHPHPHSHSHAALHHTWPLSYHNSRPTSVPISAAFQSSIPDSLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY57</accession>
    <name>A0A0R3WY57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008555">
        <property type="protein sequence ID" value="VDM27435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY57"/>
    <dbReference type="WBParaSite" id="TTAC_0000569701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000569701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000569701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000569701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10461" checksum="B6D0F995818032A9" modified="2016-01-20" version="1">MPLHSLSAAAAAAAASAEMATGASVFALPRLLALQHSLTTTAHTLLSSADTLIATNLPASTTSSSASHKFHFPPRSPTWEQFVPTSFSHSFPTVEAQATDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYQ4</accession>
    <name>A0A0R3WYQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5879</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009524">
        <property type="protein sequence ID" value="VDM27872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYQ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYQ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000589401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000589401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000589401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000589401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="271" mass="28590" checksum="EEA3DF3760A15046" modified="2016-01-20" version="1">MKVAVSKGPPFSPNATTFESQVGFWLLFQLVEHSAYAQLWRDTLSESLKSCCTGDLNGCNASNDPLLLVSVLRHLATDSLLLVGCLTERLHPVEFPSPSLSSLATPVEPATAPIIVPYVECAGGGGGGIGGGGCCGSTITVSVAGCHSSLGGPLSSEWCPPSFDSRPDLAAINASGCLWALHEIWQEVQESGQAGATTQMLNGYSGNGHPLLPSAMPPSPMRWVLCANLEASPTSPAYQIFRDGYPSDESIARLRAVRNIHLRNHDFLDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYT8</accession>
    <name>A0A0R3WYT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5913</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009682">
        <property type="protein sequence ID" value="VDM27948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYT8"/>
    <dbReference type="STRING" id="6205.A0A0R3WYT8"/>
    <dbReference type="WBParaSite" id="TTAC_0000592801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000592801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000592801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000592801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16286" checksum="1ED89A800C7551DA" modified="2016-01-20" version="1">MVWLVDAYNISHSSSSSPFKLLKSYSRDFIPIVGTFTSSSTAKVAAKEKDKVESDRGSCGGLNCLEVNESSRAHWSQPVAAEEKGDPATKHKRTASDLTCEPLMCFFCLYAILVGHLEPMENVFCVLLLNRKLFRCPLSRLLSFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZH9</accession>
    <name>A0A0R3WZH9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6185</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZH9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZH9"/>
    <dbReference type="WBParaSite" id="TTAC_0000620001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000620001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000620001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="16"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000620001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75409" checksum="4F7DEC09F2C62AD7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZJ2</accession>
    <name>A0A0R3WZJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6202</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZJ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000621701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000621701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000621701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000621701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31858" checksum="70FC6BEE4FAAA83E" modified="2016-01-20" version="1">MVAVAEGLRSCHDFGHFSSYAKTIVVSTMVMRSAVAGPLYALTEKNHALVISAYYQSAVEASNPVSSVRLKDGRIDARLQRSLFQRTFTQNCHKLRCHPSWSALYGMVQLPIWMIMTFGLRNAYWPPMIPEFLTEGLSSPSTSLCLIAATTFATGLNVEITHLKRVYAQTSTTVVTSDPKLVNQNRIANVMPARMPWQLKFAHRVGHLGTILIALFSPFAPSALVIFWCSSASHQLALHLLFLSNRVRGVLGIKKTPVDPKRPYFALWQIAKSHYRVLQLISNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X019</accession>
    <name>A0A0R3X019_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Post-transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020303">
        <property type="protein sequence ID" value="VDM30634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X019"/>
    <dbReference type="STRING" id="6205.A0A0R3X019"/>
    <dbReference type="WBParaSite" id="TTAC_0000644001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000644001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000644001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8193882at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000644001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10813" checksum="1586E565B9A2128C" modified="2016-01-20" version="1">MSGKHEITPKVNFPDIVEDETPTHKRHLTARYDKKTRRLMKEKLNLEDFIFAELRKVYLRDDDDWDCEMDVDQLIRLNESERQAYMEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0A0</accession>
    <name>A0A0R3X0A0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6523</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X0A0"/>
    <dbReference type="WBParaSite" id="TTAC_0000653801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000653801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000653801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="173"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="881"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1741"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="905"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="1760"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
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            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1799"/>
            <end position="1851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000653801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1851" mass="207491" checksum="3A39BE461D752F51" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0K7</accession>
    <name>A0A0R3X0K7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Amiloride-sensitive sodium channel subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6657</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020313">
        <property type="protein sequence ID" value="VDM30895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0K7"/>
    <dbReference type="WBParaSite" id="TTAC_0000667201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000667201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000667201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6227556at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000667201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39912" checksum="045C28DB73CF1A7E" modified="2016-06-08" version="2">MSGRPKVIAHEAKGFPLDNYGRYLYDHIVPGTQVHTFYSKNLQHSYTNRNRHCQVGPIEVLGQTYDYDQLDLVSTVFVLAKELHGFTLHNFGSNGSSWKRRMKAVYRYVATFQAACQWKKTCEYLHNECQCYCPLEILRTWDRESINRPENFWTSHPEIEEHCIHSCYYEQQIMLVDTGVCPYACNTATYQKHNEVRFPNATGLDSIEVNFIQDDAITQKTEEELFGLAKLFSEVGGLSSFFFGFSCLVIFELFESCGRFWNKWLRRQFKQRRKKRNFCRLTKSLAFCRGAACAPHCLPPAEDSPIFLCKNVHHICPFSDALPTTDCDLAVWMDIDGALIPVSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2H4</accession>
    <name>A0A0R3X2H4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM13A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7473</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020375">
        <property type="protein sequence ID" value="VDM31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2H4"/>
    <dbReference type="STRING" id="6205.A0A0R3X2H4"/>
    <dbReference type="WBParaSite" id="TTAC_0000748801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000748801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000748801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF17">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM13A-like" evidence="3">
        <location>
            <begin position="389"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000748801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56754" checksum="317B7F7BBE0472C4" modified="2016-01-20" version="1">MTQGHAVEEASIVDDVHSAFPTSDADEEDEDAKHVEEGKEGASSTTPFTHHFPRAKYRPSHVFSSPKQHNELTSRLHHGVLNYLDFDGVEDALGEFRTPPSAEANVCFIHPSDVYIPPLQPLLPPRVLIANPVCQSVTPQPRHILTWPRKRNILSRLRNRRSLDVCIPLTGQPSGGEAPIFSGASKVRLVEPSSSLDISLPDPIHLEVAGFLTVLQAVLETRRKECQRPEDVEQMSSAELAQEKLDLQKCLLYFEKAKGRPSDPITKRVMKPIYDRYRCVRRMVRLASNSAVRLSRGRSGGSAPRPSTDAVRTRTAEADEVAEPEPLMNLEQSLMPETLLGTSSTNFSQTETDQTASLISNGAEPPSSIFLNWELTLLEFIQLARRLDSNELTRGRAEILSVKHKLQRFLHDYEKRVQEATNHPPSKRDRDGLRSEYNRYRDCKQRLYVIDRFVEKPQTSPESLVVDAQLVGRAHRRRRVVESTVGNDGLIQQVATTTETATSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2K3</accession>
    <name>A0A0R3X2K3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7508</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020378">
        <property type="protein sequence ID" value="VDM31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2K3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2K3"/>
    <dbReference type="WBParaSite" id="TTAC_0000752301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000752301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000752301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000752301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21666" checksum="1C99A8F6539D88E5" modified="2016-01-20" version="1">MQLEHEILLHPKYFGPHLIEIVKAKLFSDIEGTCSGKYGFIVAVTNIDHIGAGMLLPGRGFVQYHIVYRAIVFRPFKGEVIDAVVTQVNKVGVFAEAGPLSIFISKYSIPQNIKFEGADTTNETTNEEDEEEETQIVQLEDRIRLRIIGLRVDASAIFAVGTLMDDYLGKTLRVKEKCRSFLYISAKVMEHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X388</accession>
    <name>A0A0R3X388_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7781</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020404">
        <property type="protein sequence ID" value="VDM32238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X388"/>
    <dbReference type="STRING" id="6205.A0A0R3X388"/>
    <dbReference type="WBParaSite" id="TTAC_0000779601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000779601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000779601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267958at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000779601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="519" mass="61678" checksum="FB4F7928F67D8A4D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3G3</accession>
    <name>A0A0R3X3G3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7872</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020415">
        <property type="protein sequence ID" value="VDM32341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3G3"/>
    <dbReference type="STRING" id="6205.A0A0R3X3G3"/>
    <dbReference type="WBParaSite" id="TTAC_0000788701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000788701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000788701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000788701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10187" checksum="2ED77B672EE077E0" modified="2016-01-20" version="1">MVIALRWGTALVISVALWFGALYAPVSRPHYLDLIILYSPVVAVILFGMFSIFFVVYGVLTFNDCPGEDEKLKQQINEAKRNLQKSGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3M6</accession>
    <name>A0A0R3X3M6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7947</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020424">
        <property type="protein sequence ID" value="VDM32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3M6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3M6"/>
    <dbReference type="WBParaSite" id="TTAC_0000796201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000796201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000796201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="219"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="302"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000796201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="835" mass="87296" checksum="95EAEFDB5DE3FEC7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3P7</accession>
    <name>A0A0R3X3P7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEST proteolytic signal-containing nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7968</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in cell cycle regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with UHRF2/NIRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020426">
        <property type="protein sequence ID" value="VDM32446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3P7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3P7"/>
    <dbReference type="WBParaSite" id="TTAC_0000798301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000798301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000798301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068198at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029169">
        <property type="entry name" value="PCNP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523:SF6">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15473">
        <property type="entry name" value="PCNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000798301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33448" checksum="6DD3C3788D38D77C" modified="2016-01-20" version="1">MNKSKSPDKVVPLSLKRKHSDSESKTRDPPVPLSSIPVPSNVSKKTKPCLPTKRICLSLPSKSLSDNAKKETLKLQPVSGDVAKVFGQDEEVGSEEEEMPMEARIRMRNKGRETPTSSGPNSFGKSRYGFIDRRALQNKQLEALNERVSGDNEDRFYVVLDPHQIVCYRCLLLYTMYLQFVMMAVIALHILTILLAMLTMEKVEALCGFGKVIYPNRFLQFPITKIVVPHHADIGTRWVTPDGHFDCTVFGVDALRPYVLEVSCCLIQSTDLQPWGAIKKRRLLSSIHQIFMEGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3W1</accession>
    <name>A0A0R3X3W1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoporin GLE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020435">
        <property type="protein sequence ID" value="VDM32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3W1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3W1"/>
    <dbReference type="WBParaSite" id="TTAC_0000805901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000805901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000805901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246447at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000805901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="55917" checksum="D6B88CAAE55B28C8" modified="2016-01-20" version="1">MSSSVACLRRISRLLKGASLGMRRAISRPMPEPADNIDQTPRLDFQADSTDFPSDWWVDPAQIEFSLSDELLKGMESIVVCRQCTCATLSRISPEDPRQHRKGQILKRIEEVETRALVFLTLPPPNTGGWEDIEMIDWINTIFKRFLEDAEACLTDANALLRGGIVQKESESAHSVPSFLLKPDLPKDLLVPGFSQSDALAINKTIANSVFHLLSDPDLRVTTSLVKLIIGSACSQVSFVAEMLKPQHYSIILKPTLSMLITGSDPEHCLNRLNYLLALFGGAPVRPPGAATEIFRLPEGMGTEFAWHCLLNSALAQAERQFAFSLQSVLPFAAVLATLLGRYPKYTPKFLARMASACPMLTLYVDDPAIIFASLDTELNDGVLQSWRGTSRLFAAVLLARPPPGFTQRPEHLNPKLLWITIAGIGRHVDKLDVTSEVLHGLIEVGGYVLLQLYRCQARRLFKSLTDAIGSSQSVSQLALLTCLEQLLDPATASENGHGVLLDDFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Y2</accession>
    <name>A0A0R3X3Y2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TTAC_LOCUS8070</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020440">
        <property type="protein sequence ID" value="VDM32563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Y2"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Y2"/>
    <dbReference type="WBParaSite" id="TTAC_0000808501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000808501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000808501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22382">
        <property type="entry name" value="KH-I_SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000016">
        <property type="entry name" value="Putative splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 19" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 19" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 19" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="21">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="352"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="440"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDM32563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000808501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="55068" checksum="2417167FE5A972CA" modified="2016-01-20" version="1">MSKRAYLCITDGSDSKANDPSAWAIVRPRKRRSRWSNANDDKTYVPGMPTQLPPNLTPAQEKMYILQLQIEDITRRLKTGDLGIPANPEDRSPSPEPVYSSDGKRLNTREYRTRKTMEENRHNFIQQMLELNPDYKPPIDYRAPQNKITDKIFIPQEDHPHINFVGLLIGPRGNTLKALEKETGAKIIIRGKGSVKDGKLIRRDGMPIPGEDEPLHAFVSAATPESCQKAVEKIQSIIRQGIEVPEGENDLRKSQLRELALLNGTLREHEGLARLRAMADAQNIATNKIQCTMCGGFGHLASDCKLRDPSVTMEHMGINPMERAKMDSEYTALMAELGVGYGGGGANLPPGVAPGMRSVRSGPPKQPPPPGVAPAPEEEGEEKGSGTPTSTASVMPPPPQMPAHPTAWGYMGVPNPGAAYPPAVPPAGPPGAYVAGHYPPPPPPPPPPGHRGYQGWYGPGPSGPWPHPGGPGMPPRQMGYGGDGSGADYWAQTAGYGYCPPPPPPPPAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4T4</accession>
    <name>A0A0R3X4T4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8422</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020502">
        <property type="protein sequence ID" value="VDM32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4T4"/>
    <dbReference type="STRING" id="6205.A0A0R3X4T4"/>
    <dbReference type="WBParaSite" id="TTAC_0000843701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000843701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000843701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000843701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24759" checksum="7A341D435E934B51" modified="2016-01-20" version="1">MTAQLIAEIDTLNDQDKFQEVYDKLRKPDGNYSDMSLDLMWRLARFLVLNKGPKDKKAKEEWIEEGLKVMKTAVERFPRECLSNTWYGIMLNVKSQDEGIKNKIKLGHEADPNDFMALHCLGSWCFEVASLGKVERAFATTFFGKPPESTFEEALKFYLEADKIRPDRPYTVCRIAQCYERLKDKEKAKEWAQKAIKLHAQDPEVEEVSVALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4V7</accession>
    <name>A0A0R3X4V7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8449</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020507">
        <property type="protein sequence ID" value="VDM33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4V7"/>
    <dbReference type="STRING" id="6205.A0A0R3X4V7"/>
    <dbReference type="WBParaSite" id="TTAC_0000846401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000846401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000846401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000846401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="440" mass="47943" checksum="7E6DBC5C540BE363" modified="2016-01-20" version="1">MLKRSIKEAVDVIRTLYTTLAYRAPEMVDLYSGVAIGPPVDIWALGCILYALCFFALPFGSGSALAIQTGRYTVPASASTSYSSRLLKLMRELSIVYCFSELLVNTETLQWKLFNVFAFLKMLKTEYRVDIADYMLTISGVERPDIYQVSFLAFSLLGRPNPVPNVNSTKAPDWQSLSLPNTDIVNTSSKSSSVSYPTSSSTVGVNLEGSHRANLLVSFCRQFTEVLNASTTSTSTLPEPSMTIPIKTTTVSPSIARQRPRAVVNPTSTAAINAIAKPPNPPRSSTAFQNSIHLTNILKSPQQQSGVIASTKASPPHRVGHRRGLSEASALLLNASNVRQTHSLGDLQPNFNTMNAKSATLGARIIHTVADDIDGDLFGAAFDAIRNQSAAANKVRVVVLLESHLEDLLSRTYSSLSTLQQRNDIGRNRMNFGQLKDEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6C3</accession>
    <name>A0A0R3X6C3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9035</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020661">
        <property type="protein sequence ID" value="VDM33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6C3"/>
    <dbReference type="WBParaSite" id="TTAC_0000905001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000905001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000905001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286819at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000905001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="280" mass="29095" checksum="5989277E6D28D4CD" modified="2016-01-20" version="1">MFGVSSPPAPTTEIPVLRGQAPREQLSQVPQPSSGTMNTSQQTRKWPSFSMRRSGRLSSTSSALVGVATTPTSTHGPRSSASGGGAKSSKPTTLTGGGGIDGFGGSLLRSFSAERHRVVSPTPACTVDPATPTDASASSPHKPFVVRSASSPHRKESDDGSRRVPGLAAETPATPTPSLKCLFYLTLQSTGYDAHRNSVGFQKTKKVFTNLFFGKHSKKCRSPATTPTSGGLGALQHPILPPMAPSVLSPSVSPQSRIDSLPPPHPTVSTTTLTNATDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6F8</accession>
    <name>A0A0R3X6F8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger E-box-binding homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9074</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020673">
        <property type="protein sequence ID" value="VDM33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6F8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6F8"/>
    <dbReference type="WBParaSite" id="TTAC_0000908901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000908901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000908901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000908901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46935" checksum="6F1DDFDF57ECDA54" modified="2016-01-20" version="1">MLASVCWRGVPDMESIHRQDETTTSSPTHSLSPSLPESLENSSTHRMSTSTSKTHVPACLQCGKQFANIYRLQRHQLSHTESAELRKFRCDQCSKAFKFKHHLKEHVRIHSGEKPFTCANCGKRFSHSGSYSSHMSSKKCTTGQVDTVSEVPTSEVGIFTPSPPSVLQRARSVIKPEQTNILRTYYRLNPMPSTVELQRLADAANLRPKVVRIWFQNARSRDRKGETEVLCGNDEEPLDLTVPKREAMVRSTLSLPSEQPPLPTVPLLPLPLMPPPPPSLPIPPVSHLTTPQPPIFSPQTLAQMLFVRIWQMQVGEMPLDQQQQSQPWPTYFNSWEQSLKGFTPNFPPTETSESSTTSLASPPPPQFPPISHHHFLLPTSQSPPNSEMNAIQEEGRKLVEDRFDTLCSPVESNDGGNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6H1</accession>
    <name>A0A0R3X6H1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Poly(U)-binding-splicing factor PUF60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9087</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020676">
        <property type="protein sequence ID" value="VDM33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6H1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6H1"/>
    <dbReference type="WBParaSite" id="TTAC_0000910201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000910201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000910201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12370">
        <property type="entry name" value="RRM1_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000136">
        <property type="entry name" value="poly(U)-binding-splicing factor PUF60 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034209">
        <property type="entry name" value="PUF60_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="366"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000910201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="49289" checksum="0A13C8C553EC3A54" modified="2016-01-20" version="1">MFNVDDLAYINAYRKSVTSNGTSETREPIVFGKDIKEVAPFTLITLSDEQKFAVERAKKYALEQSIQNAVRKQMSQLQSQDINNIKQTQALVLLSRIYVGSISFEIGEEEIRKAFSPYGPIKSISLSWDSALQKHKGFAFVEFEVPEAASLVLEQMNGFMIAGRGIKVGRPSNAPQTATLEAELRQDPSNKCRIYVAGVHPKLSEADIQTVFEAFGTVKSCILEPDVKFGQPEINHKGYGWIEFETEEAAIAAVTNMNGFEIAHTLLRVGRAITPKNVTSPGIAPSAAVAAAAASISARVSALENENASVSSAPAVVTSTATPASSGFSSGWGSGEHVPPPGVFVPSLTPAPAPLSTAPPPPSAVPVVLLENMVSAAEVDAYLEEEVAEECRNFGEVLRVLVHLMSDSSTVRIFVNFDSHGAAVNAVQALNGRFFDGHQVAARLYSDEEFQMRKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6P4</accession>
    <name>A0A0R3X6P4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9172</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020701">
        <property type="protein sequence ID" value="VDM33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6P4"/>
    <dbReference type="WBParaSite" id="TTAC_0000918701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000918701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000918701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000918701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17006" checksum="71A7A0043D21AA80" modified="2016-01-20" version="1">MPAIASKSTTVTSSPAVTSRPFISSKPAVTSRPAIAGRPIAANRSTAANTPFITSKPEVTSRSAVTDTRVFASTPAVTTRPFVTIKPAAASKPTINSKPVAKNKAIVIGRPIIASTPAITGNSGIARRPVIATKLFWHCKPYITKGVCIYLEAWDYVEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Y4</accession>
    <name>A0A0R3X6Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar pre-ribosomal-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9276</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020745">
        <property type="protein sequence ID" value="VDM34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000929101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000929101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000929101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="260"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="843"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000929101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1081" mass="121833" checksum="FBCBDB19A3B72604" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X728</accession>
    <name>A0A0R3X728_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-ANAPC11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9325</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020763">
        <property type="protein sequence ID" value="VDM34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X728"/>
    <dbReference type="STRING" id="6205.A0A0R3X728"/>
    <dbReference type="WBParaSite" id="TTAC_0000934001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000934001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000934001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000934001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23225" checksum="D1B7B4CE5605B979" modified="2016-01-20" version="1">MDVDEVPARPSVTPANKRFEIKKWNAVALWAWDIVVDNCAICRNHIMDLCIVVEEQETQRLVEEPRQTYEATQHAYTKYIPFFALTSNETMLQPEGDVTDMMSSILKVVETQVVDAGVTDVNFLEQQDYDARAEYYATQLSQKTDLPDSMLITLAASGNPSAILADKILRQSEINEIQNLASRIAKLIGAMYPQVTESFVVHLDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X765</accession>
    <name>A0A0R3X765_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zgc:</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9369</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020783">
        <property type="protein sequence ID" value="VDM34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X765"/>
    <dbReference type="STRING" id="6205.A0A0R3X765"/>
    <dbReference type="WBParaSite" id="TTAC_0000938401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000938401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000938401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000938401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25145" checksum="018D61C2C806DCA7" modified="2016-01-20" version="1">MATEKIMSLDYFKPNSSNSPFQPNFIPASSNVAYYSEMTEFSAPRVTENGIYPSPVAYDQSTYTKHPSNEDYTPGWSCEAVRSGFYEEGLSTPAKFSTYQDDWKEVIPRVQENLYSPKSAGSNATLIMHMVTPSDCEDEAEGEEEGGSLSGESCSEELSERGPVTVYGHSTFPQACCTPCTTTYTGSTAGRDSRGAHQYASETDSHPKGSYGLSVKANGVSFAFSHHYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X766</accession>
    <name>A0A0R3X766_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9370</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020784">
        <property type="protein sequence ID" value="VDM34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X766"/>
    <dbReference type="STRING" id="6205.A0A0R3X766"/>
    <dbReference type="WBParaSite" id="TTAC_0000938501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000938501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000938501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="208"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="337"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="466"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="582"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000938501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="719" mass="79016" checksum="77FEA90F3C1B981F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X777</accession>
    <name>A0A0R3X777_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High mobility group protein B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9382</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020790">
        <property type="protein sequence ID" value="VDM34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X777"/>
    <dbReference type="STRING" id="6205.A0A0R3X777"/>
    <dbReference type="WBParaSite" id="TTAC_0000939701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000939701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000939701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="High mobility group protein 1 homolog"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom_sf"/>
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        <property type="entry name" value="HMGB"/>
    </dbReference>
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        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
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    </dbReference>
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        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
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    </dbReference>
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        <property type="entry name" value="HMG_box"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
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        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000939701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19652" checksum="D46C24642608213C" modified="2016-01-20" version="1">MVKDKSKPKRALSPYAVFVQSMRDEYKKKNPSASIDFSAFSKECSAKWKALSAKERKKYEDIAAKDKERYQKAMKNYTPPSNDDKKKKKKDPNAPKKPMSAFFLFCQDERPKVREAHPDWSVGQCAKELASRWEQCKNRSKYDTQASQEKAKYQKAMEKYNAKKGDDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X778</accession>
    <name>A0A0R3X778_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9384</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020792">
        <property type="protein sequence ID" value="VDM34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X778"/>
    <dbReference type="WBParaSite" id="TTAC_0000939901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000939901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000939901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133214" evidence="2">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000939901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11905" checksum="8F321C0672DD3493" modified="2016-01-20" version="1">MQNPSTGTPLLLLLLLLLAFTSHFAFTNAAWIKRSRPSLNVESVDASHLSEVDEGTDDANEGADGDEESEEVLVAARSPPIRIFSQCYYDYLAKRIECYPKFDIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7A1</accession>
    <name>A0A0R3X7A1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">N-chimaerin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9409</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020803">
        <property type="protein sequence ID" value="VDM34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X7A1"/>
    <dbReference type="WBParaSite" id="TTAC_0000942401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000942401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000942401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20806">
        <property type="entry name" value="C1_CHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000019">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000025">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="388"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000942401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="516" mass="56840" checksum="FCFDE66762E9E49A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7C0</accession>
    <name>A0A0R3X7C0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-C2H2_12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9430</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020814">
        <property type="protein sequence ID" value="VDM34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7C0"/>
    <dbReference type="STRING" id="6205.A0A0R3X7C0"/>
    <dbReference type="WBParaSite" id="TTAC_0000944501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000944501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000944501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000944501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47895" checksum="56711649DC36453C" modified="2016-06-08" version="2">MASHENDFSANRLLFPCLNPSLSSHKSIDSGCCDPESSLNTCPKAFDTFNLINVASQQQQSPFQPQSTPPKRPPLNKPRSTIKKEEVATPMAKTAETPQTGGGASYKYLTWREKDRRRRFREEWKHLWLVVPHGMYEVMCLVCHKIMTQRKLDTIKRHTIRRHAELLSMSESERQRLYHDLVTQYFRRGGDFCGDSDPFCATSVPRLRQTCPRGSRMETAGVRKHPRLTDVPSPPFRARMSVPRRSGIEKHSIACSPPSEQVMNQIKPTAAMPMNLKTFENIFLNGAYSVFTKYLMGFNPTQFPPRGKFDSPMGSLWRRNPLPHTCGISTPHAFQSFKKTPSSSCNSPLRGIPDTYTDPMSCRVPLDMSTSTVPPMQASPSDLSMRRCASTNPDAGTSLTERLMRLVNTWDTAAVSSRSVALLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8A8</accession>
    <name>A0A0R3X8A8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9768</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021039">
        <property type="protein sequence ID" value="VDM34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8A8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8A8"/>
    <dbReference type="WBParaSite" id="TTAC_0000978301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000978301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000978301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="390"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000978301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137590" checksum="D609015F6DD09E9A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8R0</accession>
    <name>A0A0R3X8R0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021162">
        <property type="protein sequence ID" value="VDM34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8R0"/>
    <dbReference type="WBParaSite" id="TTAC_0000993501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000993501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000993501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000993501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9842" checksum="C2D17C6A99781CF7" modified="2016-01-20" version="1">METDNFFVNRGSLPSYSQAILTQNDPPIPRRTNAWRFSNAPRQPSANISSPQQNFMHLVVTYSSSALFSILTIFGCSRFLVFFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8S5</accession>
    <name>A0A0R3X8S5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9935</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021172">
        <property type="protein sequence ID" value="VDM34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8S5"/>
    <dbReference type="STRING" id="6205.A0A0R3X8S5"/>
    <dbReference type="WBParaSite" id="TTAC_0000995001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000995001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000995001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2377365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000995001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="25008" checksum="F1C510FF6B8D848A" modified="2016-01-20" version="1">GDVVKTPNGVRKKFNGKQWRRLCSKEGCTKESQRRGFCSRHLSMKGKEMRAFSYAAATAAATKMFAMSSTRPPQQQSSQPLCDLIYNSATSYGVPSGPISNHSKASSSSVNSSLPTPLDLLPVLSPASAWRPSPPNDGSYFNSTTPLHTPPSSSIPHWAPFPTSFASPPASIVPPSSSVFMGHASTQTSHVFATSPDKTGGSTSATSTTPVSAPITTTSFFPSGGGGAGDLPSQPITACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8T5</accession>
    <name>A0A0R3X8T5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021183">
        <property type="protein sequence ID" value="VDM34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8T5"/>
    <dbReference type="WBParaSite" id="TTAC_0000996001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000996001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000996001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000996001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9797" checksum="DEA41C9B08468D33" modified="2016-01-20" version="1">MHPNTLANNARTNTLPRDYERMMQKIMFRIGPTTLSTKKIKPMLMSKRERKFSEEARLSTPQGREIMYRRLLDGKKNLVPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9J7</accession>
    <name>A0A0R3X9J7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021427">
        <property type="protein sequence ID" value="VDM35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9J7"/>
    <dbReference type="WBParaSite" id="TTAC_0001022201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001022201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001022201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133319" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001022201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13310" checksum="31AA16341E98CEE0" modified="2016-01-20" version="1">MPLLHTLAVATSTVTTAAHAASAASGAAIALRKNIGFDGCIRVSGEEAGREEGVETVLCIESGVELPPAGDTASEACRAIWIGAVKDVGPRPVIMFSTSTDQHNSTQVNTSQLKSTQFLLPTPYHCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9U2</accession>
    <name>A0A0R3X9U2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AT-hook motif nuclear-localized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10302</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021525">
        <property type="protein sequence ID" value="VDM35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9U2"/>
    <dbReference type="WBParaSite" id="TTAC_0001031701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001031701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001031701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277820at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001031701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="9862" checksum="FDF2147067E2D4EE" modified="2016-01-20" version="1">MFSPPDLGVLAAAFHPNGLSNTTNSTGANGRFPQTTNSDEAGGNNFNTGFCSRQSAFSSPEKGVLSPRQNSYVGVTGKLNFTVSLLSEIVHAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB27</accession>
    <name>A0A0R3XB27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10737</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022157">
        <property type="protein sequence ID" value="VDM35717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB27"/>
    <dbReference type="STRING" id="6205.A0A0R3XB27"/>
    <dbReference type="WBParaSite" id="TTAC_0001075401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001075401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001075401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6280283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="171"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001075401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35423" checksum="569929F6DBE804C8" modified="2016-01-20" version="1">MENIVRKRLGENALESINDYRLCSWLSHQEDVHRMVFYIADSHCSPSAWTRRCLRQADCVVLLALASADDPTKLSPIEQALSGLTTKVTKILVLLYPLETEYPPAKRTAAWLNARPWVTQHYHIRCPPRVLNPTVKNLIKFYSQVFLLEEPNQHSDMSRLARYLTGQAVGLVLGGGGAKGAAHVGVIRVLQEAGIPIDMVGGTSIGALIGAMWSEETRVAQLSQRSRDFARVFKSIWPKLRDITYPTVSLFSGYEFNSHIESIFKDRQIEDLWVPYFCVTTDISNCKMRVHTSGKSLRFRLSFSMDLHIQLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBC3</accession>
    <name>A0A0R3XBC3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10833</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022327">
        <property type="protein sequence ID" value="VDM35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBC3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBC3"/>
    <dbReference type="WBParaSite" id="TTAC_0001085001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001085001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001085001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001085001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14797" checksum="6C79B6352747A8C5" modified="2016-01-20" version="1">MGVEKSMCFLQAFIDAFDAEPEAEDEEIVEDKSTDEAKTADEEKSGVDCVGDADVGELNLMPNSEDEAEAAAAEEKAATLSKGLSAARRRQLERALRRKAGRAGRHFYEEVNTKNRKRRRGGAESRLSDRLSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBF9</accession>
    <name>A0A0R3XBF9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10869</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022402">
        <property type="protein sequence ID" value="VDM35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBF9"/>
    <dbReference type="STRING" id="6205.A0A0R3XBF9"/>
    <dbReference type="WBParaSite" id="TTAC_0001088601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001088601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001088601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240031at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133291" evidence="2">
        <location>
            <begin position="16"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001088601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="477" mass="54309" checksum="2881B2CC1BDF1F66" modified="2016-01-20" version="1">MFWILHTLIFSAIVARPNTIYNPFDVVVDLFHILQSSFFQMFGEFQAEEFIDYYGFRECKNITTPGCTYPGYKVFIPLLMAIFTMVTHVLLINLLIAIFTKTYDRMEAISQQLWTMQRYRLIEYILAESVQPGPFLIFSLIYQLAAAICRPKSLKKSNTQKPFCKSFEDNPGRERQLINWEKLSALVMMGMRDEDHELKKASKSDIALERMRKTMGGWRAPNDRSWQIVRRIVSPALALQNIAKSGPVIDDLEGRFDDINAKLDKISNIISGRLIESKALSPSTLKPYLMPSREGSRRSSLSSVDTADVPIMGQWRNHQIAIFSSLTSDTTPHALDPPIPWEVSYPKYHAIPWSPRRYMVPQWQTNAVPTAEVSRLHSFDSANLTFNDSLPRNPEGRVGTAGKGLLPKYGVNLACIVVVTRGSNNDEIDIGSSSDPLNCDNAWLSVTVVHFQIPSNYKWVSDLENVRLLFFTLAFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBH0</accession>
    <name>A0A0R3XBH0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022420">
        <property type="protein sequence ID" value="VDM35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBH0"/>
    <dbReference type="STRING" id="6205.A0A0R3XBH0"/>
    <dbReference type="WBParaSite" id="TTAC_0001089701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001089701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001089701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001089701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8056" checksum="6C92CD6E6CF455A5" modified="2016-01-20" version="1">MCGGKSELSHLLLPSLPAGYPVPYVFLADEAQTLGFSAEASANLLVYLSSVNTVGRVMAGECLDPPFLLPSLLSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBL7</accession>
    <name>A0A0R3XBL7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/arginine-rich splicing factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10927</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022544">
        <property type="protein sequence ID" value="VDM35907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBL7"/>
    <dbReference type="STRING" id="6205.A0A0R3XBL7"/>
    <dbReference type="WBParaSite" id="TTAC_0001094401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001094401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001094401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001074">
        <property type="entry name" value="Splicing factor, arginine/serine-rich 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001094401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15656" checksum="AE7946A00D3E315B" modified="2016-01-20" version="1">MPRSRSVTKVYVGDLPRDASEKELARVFDRYGTVRNVWVARNPPGFAFIEFEDAADAEDAVRDLDGTVICGVRARVELSNGRTRPKPWIRGGRDGDRYGERRTRPFDPNDRCFECGERGHYAYDCRRRRSSRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBY6</accession>
    <name>A0A0R3XBY6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MHD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11046</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022800">
        <property type="protein sequence ID" value="VDM36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBY6"/>
    <dbReference type="STRING" id="6205.A0A0R3XBY6"/>
    <dbReference type="WBParaSite" id="TTAC_0001106301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001106301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001106301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD2" evidence="1">
        <location>
            <begin position="85"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001106301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28737" checksum="916BCE0D8CE0B362" modified="2016-01-20" version="1">MNNIQQCRVQLEKVYEAMGGDENLKEDTKAVMHDLQQMLNDAIDEMAEKYSVALRPIVLGKIKEVNKLLHQISSNSKANIDSEADLVLRPLMDHFESSLSVYADICEKTVLKRILKELWKITMYTFEKQVVLPPVSDPSALFLNLSIPSNATAKLTSVSQTLLSNVSSQLPNSKLLQEMSKESSNVTLKNLTLHHCQILAIALDAIKSYFHAGGSGLKNNYLEKSPEFQSLEHALSLYTQPTDTLIKNFVNSQKSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBZ3</accession>
    <name>A0A0R3XBZ3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS11053</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022820">
        <property type="protein sequence ID" value="VDM36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBZ3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBZ3"/>
    <dbReference type="WBParaSite" id="TTAC_0001107001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001107001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001107001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF3">
        <property type="entry name" value="INTEGRIN BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0401">Integrin</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="13">
        <location>
            <begin position="45"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001107001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28813" checksum="F54F84D9248CFCE4" modified="2016-01-20" version="1">MVIVDADWVNESDRIAHCIYWGGLVALPVNGGKCNCFTQCQLARNCQECMGRGPPCAWCFDDAYDDTAEGPGYRCAERDVLLERNCPADKIESQNSTLVDVGSQDTDAQLTPVRQKVSVRPHDSLRTDFTFQSITDYPVDIYFLVDQSYTMRDDLETVSRLTKDIANSFTAVTKDLRMGFGAFVDKPVFPFIVPTPEAQVNPCLYGVGNQDLQCDPPFLYKHILSLTGDFAEFERKTILSRPSGNLDSPEGGLDALLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCC6</accession>
    <name>A0A0R3XCC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prothymosin alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11186</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023148">
        <property type="protein sequence ID" value="VDM36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCC6"/>
    <dbReference type="WBParaSite" id="TTAC_0001120301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001120301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001120301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001120301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10354" checksum="25C01D35AD8C5218" modified="2016-01-20" version="1">MVIDEVDEDDFEATDSENDYEGGGGEGEKKDSDDDNVQRPPITLKQGVEIEEVFDESEQAASKNEMECVENSGVEDDDDAVAEDATLPTIWTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDI8</accession>
    <name>A0A0R3XDI8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11598</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025438">
        <property type="protein sequence ID" value="VDM37235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDI8"/>
    <dbReference type="STRING" id="6205.A0A0R3XDI8"/>
    <dbReference type="WBParaSite" id="TTAC_0001161501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001161501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001161501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM37235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001161501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7593" checksum="C73260203BE70717" modified="2016-01-20" version="1">MIAQAQSGTGKTATFLLAMLSRVNIAYERCQCLCMAPTRELAVQIATVGREMSRFIPKISFGLAVREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDC7</accession>
    <name>A0A158RDC7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS372</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000030">
        <property type="protein sequence ID" value="VDM16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDC7"/>
    <dbReference type="WBParaSite" id="TTAC_0000037101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000037101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000037101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255205at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000037101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="810" mass="87888" checksum="CBF12F98600C9610" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB6</accession>
    <name>A0A158REB6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase BRE1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase BRE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS7019</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020339">
        <property type="protein sequence ID" value="VDM31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000703401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000703401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000703401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000040">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058642">
        <property type="entry name" value="BRE1A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26052">
        <property type="entry name" value="BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="1305"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="798"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="963"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="434"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="650"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="908"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1074"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1255"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="996"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDM31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000703401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="152947" checksum="C76C07C928C01CD7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RED9</accession>
    <name>A0A158RED9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glutathione transferase</fullName>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7108</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="function">
        <text evidence="1">GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RED9"/>
    <dbReference type="STRING" id="6205.A0A158RED9"/>
    <dbReference type="WBParaSite" id="TTAC_0000712301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000712301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000712301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000020">
        <property type="entry name" value="Glutathione S-transferase P 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="10">
        <location>
            <begin position="173"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="11">
        <location>
            <begin position="262"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="10">
        <location>
            <begin position="350"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="11">
        <location>
            <begin position="439"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="550" mass="64308" checksum="CE43F9A313B0A0B8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REX8</accession>
    <name>A0A158REX8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome biogenesis protein NOP53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020476">
        <property type="protein sequence ID" value="VDM32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REX8"/>
    <dbReference type="STRING" id="6205.A0A158REX8"/>
    <dbReference type="WBParaSite" id="TTAC_0000829201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000829201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000829201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260427at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026680">
        <property type="entry name" value="CCDC137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000829201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34635" checksum="1DDED62BF5316C86" modified="2016-06-08" version="1">MKKSTKKRSRRQGIKSTQLKREIKRNKPAGIKPILYTRRLKSRKQRKIKEVDPQLWSNALDSGLDDDPLSDDEQRPPSSFLEMIGRINEKKSDTGNMLKKPDVIPKQGENETPESYARRLDSCVQDELMRIAIEKADKAPLVDPETYKSEKARRALKRLAMKKARKKAFRMEKHLTGFEHLKDEVAFNEVVQGPPVLTTKPKKVGGGSRSFVAIKLHYVVTVLFCQGVVVGGLLSRVLFALLQWCPDNVFSLNAIFTMDPDALKLLEPIGACEQLSGLMVTEVGGRPRAVSKTVPNRSDELSSALVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ECF2</accession>
    <name>A0A3P7ECF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001227">
        <property type="protein sequence ID" value="VDM20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ECF2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="202" mass="21528" checksum="66A838455B6088AA" modified="2019-02-13" version="1">MMQSQHAMAVKSQTQPYSPPLSTETILSTHPNDSSVFPPPAGDSASQCPDDGLVVSDGTQNGTVSPASAASRNDTNGIEDHSNKIVGGELGSFSKKLDETEEKVNSAETDASAGAKCGAHEKEEREEKEAENDVFSGLSDHENPCDDGLSREQRSFARYESPRDVEGREEKTVEGGEEGKDGVTKERVTQLASFDSPIPAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EIY7</accession>
    <name>A0A3P7EIY7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EIY7"/>
    <dbReference type="OrthoDB" id="9998697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="167"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="869" mass="95577" checksum="3CDAE3096DE454CF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQU7</accession>
    <name>A0A3P7EQU7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005301">
        <property type="protein sequence ID" value="VDM25620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQU7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="46" mass="5109" checksum="F2FE2BEA8B59D68C" modified="2019-02-13" version="1">MRIANLRSLSMASLSTGMLQSSFIMLVPFSLEKGRTSLSILLMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EWN9</accession>
    <name>A0A3P7EWN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005488">
        <property type="protein sequence ID" value="VDM25763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EWN9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018042729" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="165" mass="17741" checksum="3B1E99EA9AD9979D" modified="2019-02-13" version="1">MQRFLLFVVSTDVPTLCAAPASPHPMHQIFGLNFEATENGVLKSGPVVVPESWRSLCSSFYFIPPQYKMSNYKPPSSLYYHQTASLAFVTPSDALARLPAFDEGPTTGSPMSASPVVTGMESAAAAEEAVSLGPTESQKACAHLLQRLAVEIIEAVLAYEAEHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F408</accession>
    <name>A0A3P7F408_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003046">
        <property type="protein sequence ID" value="VDM23359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F408"/>
    <dbReference type="OrthoDB" id="6258727at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="379" mass="43714" checksum="F04DF1B9BE71286E" modified="2019-02-13" version="1">MTIGSYWLFLTVLGFKVDGIICHCFFDFYGISLSPSERSFYALSLMKKFEQMKFPEPFTSSDFAEERDPKKMSRILSWLFQFFETFAPANEYAYSVWNSYKEKASLASSLKQKIDSLRIINKAEEEKRLEYQNNIVELQSSLSAKLTSKRQLDERVSSESRKLALLTESEKSHSLEVTVVNFFFIATALDKKLYELKAKRESLLPQVIENPGVLPKAVEELKAKLNALELEMQEIRAKTFQVDQSISEFKRLHDVIENQLVTVARTCHSLLFQMSQSQRDLEIYDKEIAGRFASIELLGKKITDATEQLCVSEHNIVKAKVMDATRAVNDERIKKERAALLDKYCFAFKSLEPDVTAKEALLKTTKILFEREYSNKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F9W2</accession>
    <name>A0A3P7F9W2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020475">
        <property type="protein sequence ID" value="VDM32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F9W2"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="184" mass="20737" checksum="0F8196FA9219BBB3" modified="2019-02-13" version="1">MPLSDVAPSGEICGHAGNYAAFLSPFSILVEPQGSPLDLSKSYLSSQGTELKAKTNFAADNNYINPRMRRHPEMTPNEAKDVKYWERRCRNNAAARRSRQCRRAREADLVEYAAQLERKNSALEAEICLLRVQLANAKCECAKLEGAIPFSPIILQRKYSMNFRIYTAQSSNPWITSPNLLAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FAI3</accession>
    <name>A0A3P7FAI3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="4 14">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 14">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 14">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12922"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="UYWX01020498">
        <property type="protein sequence ID" value="VDM32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FAI3"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 14" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="59"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="444" mass="48649" checksum="AD47E69A6FABE90A" modified="2019-02-13" version="1">MRGARQTTSFDYSTFFQEQVEKQQANATYRVFRQILRDTKRYPFADDFSTGKCQTINVWCSNDYLGMSRHPMVLESARNRKLLGLAMIFLKSTLINESKQVFSLASRNAINRFGIGSGGTRNISGNTLLHEALEHELADLHGKEAGLVFTSCFVANEAALYTLGTLMPGVKFFSDAGNHASLIHGIRTSRAPKYIYGENDVGQLDELMQQHSTQIEPKLAVCETVHSMNGTIVPLREFLDVCEAHNALSFVDEVHAVGLYGDHGGGVAEELGCMHRIGAITGTLGKAIASIGGYLVGDRALVDAVRCYAGGLIFTTSLPPPVVAAARASLAILKSTEGRDLRAEHRRRVNLVRSRLKEAGLPVAYVSSHIIPIAVGDAKMCTSISEGLLRNHQIYLQAINYPTVAKGTERLRLAPSPFHTDAMTDHLVDSMVKVWRSHGLPLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G7R0</accession>
    <name>A0A3P7G7R0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000520">
        <property type="protein sequence ID" value="VDM18542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G7R0"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="116"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="472" mass="52721" checksum="461136BE31A9E69F" modified="2019-02-13" version="1">MPIHQPATASVIPICHHSLTTRVIPTSSRPFSICNFNCSVPMVSVASSIPTQQNQRPTSRLDKDVDRGSTPRTPPNTSSISTQTPAFIPPTSVVTAVSAKNMTGRVYSALNYPYDLSFQIWQFFVENRQSPATYGKKVHFRNALRLIISSVFQNSKLFIVGSSINGFGWDQSDTDLCLVVTSQELQNKRDASAVLYQLMTPLRKCSFIRNCNLIRAKVPILKFRDQLLDIECDLNVNNVVGIYNTHLLAMYAKVDSRLRPLGVFVKHWAQKMDVHDGSRGRLSTYPLILMLIQFLQCGCSPPVLPNLQARFPKIFDYERPVKELDMRLQLPWNEMHSANTSTLSELFAGFIAYYATFDFTRWAISVRCGQPLPIDVAIRCLPPHEQAHTAASFKIFVEGGLLVINETPRRRNVGGGGGEPFCKANAARSLYDETVLGQIQQAFNRTDGVLRAQKPLESLWKPSSSSSTTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GH63</accession>
    <name>A0A3P7GH63_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">16S rRNA (Cytosine(1402)-N(4))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001800">
        <property type="protein sequence ID" value="VDM21742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GH63"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13988" checksum="DFB6B105C00161E0" modified="2019-02-13" version="1">MATQIFLALRIFVNDELNELCVGLEAAHRLLRPSGRAAVISFHSLEDRLVKRAFAMQGYHAHGLAQRLADSSSVKSPYGHFWREQRPNLWRQVAGPIRPTSAEVLVNRRSRSAKLRVGEKTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HG85</accession>
    <name>A0A3P7HG85_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020776">
        <property type="protein sequence ID" value="VDM34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HG85"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16727">
        <property type="entry name" value="RING-HC_MIB1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="247" mass="26797" checksum="F460372E30FEC895" modified="2019-02-13" version="1">MNRALEVAGDNDDEQMKPEWLMGEGEGEQRRQQLLLSLFNAGELCPDGVCPECGQIVTAVWSLEVAVGGVSTAIERFPVLPSSVADVGTARRTALISTNSQDLLVPIAASQTSGVWVASENNQGKHPMFFVAGTSVTPRCLVPKSILTSTGRETLPRYTQAGGTNARPNNMRSSGSVISSGQSSSRELKRLQHELQAMREQTRCPICLDRSRNLVFMCGHATCQWCGDQVAVCPICRRTVTGRIVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHK4</accession>
    <name>A0A0R3WHK4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS25</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with SYS1.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000002">
        <property type="protein sequence ID" value="VDM15640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHK4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000002401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000002401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000002401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04160">
        <property type="entry name" value="Arfrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM15640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000002401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23938" checksum="783DD770FFE22747" modified="2016-01-20" version="1">MYTLIRGFCRQIIKKDEYSVLILGLDQAGKTTYLEQAKTKFNDSYRSIPPHKITSTVGLNIGHIVLDGIIMKFWDLGGQTELQSLWDKYYIESHGVIFIIDSSDPDRFNESKAAFGNCHLDKMIQNHALRGVPLLIIANKQDLDVGYHAPDHFAFPVSEVRQVFQNSAHLIGSRDCSMRGSSALKGDGVIDAIRWMAEKMKKNSLQRPPNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHL3</accession>
    <name>A0A0R3WHL3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="9">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS37</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01000002">
        <property type="protein sequence ID" value="VDM15653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHL3"/>
    <dbReference type="STRING" id="6205.A0A0R3WHL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000003601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000003601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000003601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000002">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020552">
        <property type="entry name" value="Inositol_monoPase_Li-sen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00378">
        <property type="entry name" value="LIIMPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM15653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000003601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25854" checksum="7478271DCDD97B7A" modified="2016-01-20" version="1">MGSLEGCCGEVMGIQMQWKLIVSAFDQPPHYHEKVSFADLVTDTDKQVEDLVKSRILETYPDHKIIAEESTSGRSILTSDPTWIVDPIDGTSNFAQFAVVYNPICDQMFYAERGKELHSALILTDWGGDRNASNLDTKAANIRRLISEARGVRTMGSAALHMCQVAAGQGDVFFEFGIHCWDYAAASLIVTEAGGYCCNVDGGPVDLMARHCVAASSKQLAEVICQKIVPISYPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI11</accession>
    <name>A0A0R3WI11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ILEI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI11"/>
    <dbReference type="STRING" id="6205.A0A0R3WI11"/>
    <dbReference type="WBParaSite" id="TTAC_0000020501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000020501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000020501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052003">
        <property type="entry name" value="HR_DNA-Binding_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15361:SF5">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15361">
        <property type="entry name" value="RAD51/NUKS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000020501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="867" mass="96751" checksum="C92C22B58E474469" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI68</accession>
    <name>A0A0R3WI68_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum-Golgi intermediate compartment protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS277</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI68"/>
    <dbReference type="STRING" id="6205.A0A0R3WI68"/>
    <dbReference type="WBParaSite" id="TTAC_0000027601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000027601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000027601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="143"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000027601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41135" checksum="F03A434A9BF261A7" modified="2016-01-20" version="1">MMSPAFLSRSLRRFDAFAKPLKDFRIQTVPGAFLTIVFLLIILVLFTWEVADYLSPSIKQEIIVDISRNRHMSISFDIIFPFVPCYVLSVDSMDISGEQHSAITKDVNKTRVLPDGSAVDSNSDSDKMKALELKRSKDYCGSCYGAGIEDNRCCNTCESVLEAYRVRGWSVPDSDAFEQCKDEREAGSLVSIGREGCRLVGQLGVNKVAGTFHIAPGKSYGQGHVHVHDLMAFSGKQFILDHQIRHLSFGDTYPGQINPLDNTNMSDKTKSPMISYFLKLVPTIYSDFSEKTLVTNQYSATWQVRSTPLTGGSEGIPGVFFNYQISPLLVKLAKERRSFLHFLTNTCAIVGGVYTGMFLRLLNIIVGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI76</accession>
    <name>A0A0R3WI76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1 family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS286</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000020">
        <property type="protein sequence ID" value="VDM16195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI76"/>
    <dbReference type="STRING" id="6205.A0A0R3WI76"/>
    <dbReference type="WBParaSite" id="TTAC_0000028501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000028501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000028501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000028501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="80489" checksum="DBFD92CA9722AD26" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIH8</accession>
    <name>A0A0R3WIH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS404</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000033">
        <property type="protein sequence ID" value="VDM16392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIH8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIH8"/>
    <dbReference type="WBParaSite" id="TTAC_0000040301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000040301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000040301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000040301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24377" checksum="C6034F5898CB4099" modified="2016-01-20" version="1">MPLLDLKSEVEVSTFLRDCKQLTLLYLFTPWAPECQQITDVFRTLAEDCENRTVRFGMVNAEDVQDFCKKNEVSSVPVVLFYKDGKPVARVQGAKAAELTRTVTSLRGENYVQESLNARLKALINRAPIMLFMKGTPEEARCGFSRRMLEILHKHNVQFDSFNVLGDEAVREGLKVYSDWPTYPQLYAHGELVGGVDIVTQLEENNELLSTLGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIQ7</accession>
    <name>A0A0R3WIQ7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS497</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000045">
        <property type="protein sequence ID" value="VDM16535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIQ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WIQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000049601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000049601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000049601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000049601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11080" checksum="258161911A74B473" modified="2016-01-20" version="1">MAANSKDENSSNKAKPVVDLGILEADDDFEEFPADSCTIGTCEDNGEVSLWEDNWDDDIVEEEFSTLLRYGRSLLTVFRAEFQKLGKAFVLPDIVPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ77</accession>
    <name>A0A0R3WJ77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS712</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000082">
        <property type="protein sequence ID" value="VDM16882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ77"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ77"/>
    <dbReference type="WBParaSite" id="TTAC_0000071101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000071101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000071101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="480"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000071101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61167" checksum="62D5C7DC3E1E5C60" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJB6</accession>
    <name>A0A0R3WJB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000090">
        <property type="protein sequence ID" value="VDM16944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WJB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000075601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000075601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000075601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271780at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000075601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="81263" checksum="BF4217DD8BA6A193" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK21</accession>
    <name>A0A0R3WK21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1049</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000166">
        <property type="protein sequence ID" value="VDM17366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK21"/>
    <dbReference type="STRING" id="6205.A0A0R3WK21"/>
    <dbReference type="WBParaSite" id="TTAC_0000104801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000104801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000104801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283545at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000104801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20786" checksum="F2DAD2FA9EC384E8" modified="2016-01-20" version="1">MGADINAVDQLLCVFKKMYYRDCLFEIWLPSFIRFKLGDGNGWTSLHWAAQQNRVDVTCILLRHGANRRAKDCHGHMPYEVTTNAEMSEALRPDAFYPQIESNGAVSTDEEEASASESSSDEADGGDRKVGAMPSYHYLRRLNYNRRNRHQNRLRTHLSPTVEAPTQVRLAHDDEDGCLGAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK25</accession>
    <name>A0A0R3WK25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1053</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000167">
        <property type="protein sequence ID" value="VDM17382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK25"/>
    <dbReference type="STRING" id="6205.A0A0R3WK25"/>
    <dbReference type="WBParaSite" id="TTAC_0000105201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000105201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000105201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000105201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="507" mass="53799" checksum="7870BA63A82A14FE" modified="2016-01-20" version="1">MLKTNSFPGKRSGTPDSTTSGQRTVSPAHNAGPGSPTSPVVATNHHPIPHVQHHQNHRPYFSRGRCRGDGGYYGGHNHFGGHHSGPNRRCSPPIHGPPYSKNLIDFMIKEWDKFSEHYYSTHPEDLPDNEPMVHTGHQHQQHQQLVPTSPRVGGHMNSPHRGQHNRYNHQNSSGNSWSISNGGNGRKYSENGDHSNTGSLRRHHNHRGGHAPSPLLQGNQPWQRGTLTNRQNSPNNTLNRSTGPRHTYSSRSIASPTPPSVASGAVSVTSAATSPVAESTNKVVESAAVPVTEMHSLSLKSSDSPKSSSAVPNGKKNSEGPAKPISTASATFLDPESKKKTTSLTTTVTSRDEAGSSASTSSTSSLTISKVKQQQQQQHTPGVQQQYHHSTRRRAATTQGGSSVSASTTATVLPLSSSLPAARASETASVASSSFCSLVDQVDTMSAADQYFTPEPPSPSSSASASLSVVVSETFQHSTVKSAESPPLSSPPPLAPVPVSPSATISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKM0</accession>
    <name>A0A0R3WKM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1265</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000239">
        <property type="protein sequence ID" value="VDM17715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000126401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000126401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000126401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="56"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000126401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42590" checksum="6C83977C73BB7FEF" modified="2016-01-20" version="1">MLKEACNNTLPAPECLLSTCTVPWASSKSIVEATREIHFISITVFGTPITCIGLITSLLCTILFICYPIAQQTTRLLLIVNSIVDTIYLATLSISRLVAVIVPLGVYENIYLLIFDGLSNLFALFRNWTIVLIAFERFVLICHPLAFKSKAGDKWAIQALIGTIISTVIVRIPTLLIIIFEDLRYCNAATISFSIDAFTDILFFTILPLILLTTFTVKILTQARRLRHWRKSQSVKDKERNMAFDRMNRRIHRTIMIVLATFTILITPFLPNGIIRMIIALGNDWCLVYLARHITAAMAYNGSLLNSTTNCFVYLITWPKFRSYLRRMLLAPFSCLFERYPRRSLSEEKNTGITCEQSRSEFQVSVECTNGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKQ5</accession>
    <name>A0A0R3WKQ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1304</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000254">
        <property type="protein sequence ID" value="VDM17779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKQ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKQ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000130301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000130301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000130301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000003">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="27"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000130301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39340" checksum="BB6D6806A00F6283" modified="2016-01-20" version="1">MDVVPPYKQEAPKTPPHVILHYVAFKTAWDWMILFLTGYTAVMVPFNAAFRSKTIDDVIFLVIDSIVDVIFFIDIVLNFHTTFVGPQGEVISDATVIRINYLKGWFIVDLLSCLPYDVFNAFQPEATQSTISSLFSALKVVRLLRIGRVTRKLDQYLEYMAASLFLMIFGFVLLAHWLACIWYSIGMSDLENFIHYGWIPRLSSDIGLTSKNYSLFDAKNISVSRSMTYITALYYTLSLITSIGFGNVSANTFGEKIVSVIFMLIGAFSYATIFGQITTIFQGMYAARSRYHDMMGSVKDFVKTHNVPQDLAERVIDYVTSTWAITKGIDTAKSLESHFASGEKEGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLA2</accession>
    <name>A0A0R3WLA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SLED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1527</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000358">
        <property type="protein sequence ID" value="VDM18153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLA2"/>
    <dbReference type="STRING" id="6205.A0A0R3WLA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000154001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000154001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000154001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20094">
        <property type="entry name" value="MBT_SFMBT_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF129">
        <property type="entry name" value="SOP-2-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="169"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="300"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="SLED" evidence="7">
        <location>
            <begin position="653"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000154001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115954" checksum="A2B7F4EE0080EB0E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLV4</accession>
    <name>A0A0R3WLV4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1729</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01000473">
        <property type="protein sequence ID" value="VDM18455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLV4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLV4"/>
    <dbReference type="WBParaSite" id="TTAC_0000174201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000174201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000174201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000174201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35279" checksum="7B0FF3E62FDA9924" modified="2016-01-20" version="1">MASMSDLDRQIALLRECKLISESEVKALCAKAREILIEESNVQYVDSPVTVCGDIHGQFFDLIELFKVGGEVPDTNYLFLGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITTAYGFYEECLRKYGSPLVWRQCTEIFDYLCLSAIIDDRIFCVHGGLSPHIERLDQIRAIDRKQEVPHEGPMCDLLWSDPEDSAGWNVSPRGAGFLFGADTVQQFNHVNKLDLICRAHQLVMEGRRYHFNETVLTVWSAPNYCYRCGNVAAILRLDEYLNRDFAIFEAAPQNNRNFPARKPVPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM60</accession>
    <name>A0A0R3WM60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000543">
        <property type="protein sequence ID" value="VDM18575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM60"/>
    <dbReference type="WBParaSite" id="TTAC_0000184801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000184801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000184801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000184801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17827" checksum="731C319EBC5871FB" modified="2016-01-20" version="1">MDEWKGRDDVQACVTATVKQTMSGHVMVRHDQKHINGRYSMAVEAMRGSYGELALQLQMPWCAKWVTSLDARSVRFVLVSTLIVRRNGMSVHALPPCSALIEVLKLCRLAAGTHHIPAFAWRSPTLHHNIVASLPKIESTLFSVNPSVNRCTTPHGASAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN07</accession>
    <name>A0A0R3WN07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2132</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000782">
        <property type="protein sequence ID" value="VDM18989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN07"/>
    <dbReference type="STRING" id="6205.A0A0R3WN07"/>
    <dbReference type="WBParaSite" id="TTAC_0000214501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000214501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000214501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6238402at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000214501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="67126" checksum="1EE6105701A9931D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN78</accession>
    <name>A0A0R3WN78_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000846">
        <property type="protein sequence ID" value="VDM19214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN78"/>
    <dbReference type="WBParaSite" id="TTAC_0000221601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000221601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000221601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="90"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000221601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21091" checksum="3A221C478B20CE96" modified="2016-01-20" version="1">MRKPTFKAEFLSTLSTLQISIDNPLGVEGRFEGYEVLMKDGGLVSVHPWRSVVNLSASERHYNVRRIQAPTLRSVTVRGRLSADQFSLSAPQNVKLIPFDSDRALMTWDPPIQSYGNVTGYSIVSRVGNETRPLIDPPPDRTYVFKDLKPNQTLSAFVFATSQPESQVNIKLRGYPSHFLSLTKPPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP33</accession>
    <name>A0A0R3WP33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2508</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001156">
        <property type="protein sequence ID" value="VDM20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP33"/>
    <dbReference type="STRING" id="6205.A0A0R3WP33"/>
    <dbReference type="WBParaSite" id="TTAC_0000252101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10458139at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16108" checksum="B91B3B9B5FE155C1" modified="2016-01-20" version="1">MSEMLSSMSKEYREIAQQLQRSRPDLRYPDLYVEMYEIGESTFAQHSLMSVSALTAQSTTDATNVTHFPSASTLIQQPVAMLPSISHSVPSSSTAHWSIASNSIKPEDSVWSIQDHWNDTTPSISSASPYQISNFLDSNRPPTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP49</accession>
    <name>A0A0R3WP49_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2524</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001172">
        <property type="protein sequence ID" value="VDM20345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP49"/>
    <dbReference type="WBParaSite" id="TTAC_0000253701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000253701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000253701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000253701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16966" checksum="D2BA36B6D503711B" modified="2016-01-20" version="1">MAFSDTPHEISPILSSAKGAELPRNISSPKTKARCDHPESDHESLMLHINRRSSLATVTSTASDIPVMEMDFSSFPRRNSEHRTIGLRTKKYLLPRLLSHRKFALTVLHPSSAAVMNDIHYLLKVSIAPRALPCTDPSVKGSLSAVLYLDLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN0</accession>
    <name>A0A0R3WPN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PABC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2705</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001408">
        <property type="protein sequence ID" value="VDM20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000272001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250244at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="32482" checksum="6569C551D40245E1" modified="2016-01-20" version="1">MPAHADRSSEHEADVNEPLRKKMLLEANCTGLLLACKGGVEATNTSKIPIGSSIEAVPKTTIEVELQDPVILERLKGTIKLKLQGSITQAVKGLLNMVSLSIEEVNCLKKLTQELHKRIRKLETISRKVEALIVESMPPPPKPVAAVADHLLELNTVVISPSQSQQPSEETTETSTTAYVSTGTFAVSPSLPSSSHSPVQMSHVLPPQVSQPSSDPTVTADVTYTTAHLAVETPQSVVSIAPLPTCNFSVSSFDALSICVQPPLLLSISVSSEGESTFQFLFYVFTLKSNGLFDALGRKRGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ22</accession>
    <name>A0A0R3WQ22_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2846</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001582">
        <property type="protein sequence ID" value="VDM21318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ22"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ22"/>
    <dbReference type="WBParaSite" id="TTAC_0000286201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000286201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000286201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250534at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000286201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12898" checksum="20F429132BDD4626" modified="2016-01-20" version="1">MGYQRDLETTVHMRLYSMKKVHVFFYFLIFTTIVFLSTVAGIMGPPVLTRNNHYATKILPEGRTLYDGFYKVIADPVMLFQREIWFSSVIHQGKPDGKLQTVPLKWLLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ76</accession>
    <name>A0A0R3WQ76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2901</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001656">
        <property type="protein sequence ID" value="VDM21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ76"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ76"/>
    <dbReference type="WBParaSite" id="TTAC_0000291601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000291601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000291601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="9">
        <location>
            <begin position="316"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000291601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="533" mass="57596" checksum="903D45929B6E858F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQL5</accession>
    <name>A0A0R3WQL5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DZF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001835">
        <property type="protein sequence ID" value="VDM21805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQL5"/>
    <dbReference type="WBParaSite" id="TTAC_0000305501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000305501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000305501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000305501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18291" checksum="5DB15D929E4E462E" modified="2016-01-20" version="1">MRGGNIKVAVEVVAQLIARSYDGAQSRTVTCLTPPVTVAVPPPPPLQTPTCSTRMKALGNSHASGHTRSRQDVEVKEVKEWISRLAILIAGTSIHTPANPIPLFRGHNEASWWWWWWWWCCTGIGKLTMTRATRGEEGGEGKEERKAKEEMKKTTVVATNMSPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQW7</accession>
    <name>A0A0R3WQW7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PFK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3142</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001978">
        <property type="protein sequence ID" value="VDM22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQW7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQW7"/>
    <dbReference type="WBParaSite" id="TTAC_0000315701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000315701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000315701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000315701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="34848" checksum="109BD85BD7E5344F" modified="2016-01-20" version="1">MGMGDVHQIPSQWEVIELILHRGMSNGEWDRLGIVPGLQGDSQQKRPSVGRTSGGLFGYIADPNDSKTPPGIGEQNTGPISGSQLTHKLIDRDNSSPASGVPTQAVEAAPTVRTHVNLTMHMRVKIHFERADCSIPSCFGMAIGETLDNNKNVQEIDATNLVISPGLVDYSATSNAFSNKLGVEGMADQALIRDATSQSVLAGVTTIVDTVYSDDGHSPLSAIAAYLQALQTTHVHCNVAVRAGIRHLSVGTISDIEQLTKRHCIKSFLLSIPENDRILCEHGNPESTVLYGVLSACRSLGVVPTIGLDRITGSHVPQTEGVRFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRA6</accession>
    <name>A0A0R3WRA6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3281</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002179">
        <property type="protein sequence ID" value="VDM22307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRA6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRA6"/>
    <dbReference type="WBParaSite" id="TTAC_0000329601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000329601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000329601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26722at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133053" evidence="1">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000329601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31393" checksum="76AAA10D60FAEB7A" modified="2016-01-20" version="1">MVLVLQLLQPLLLCVPTANCAKIEVPVFVNYVMTCNIFELPAKPRLEDFYWFQNGRLNRGVNYVLLPHGEIPFEGISPDATGIYRCCYGGFVKVLCAEEIHLIVKAPRPDIFRNTLLNITPQIFPNSVYWLPQMLTTPLEVEMTTEPLKFECFYFVQSFTTRRPRVAWYFNDFYPEDRLFESLVQANGERYAVKNEEIVCEEDYMQHWRSHCFKSTLTIRRPSDVGRRVVFTCEVNMIKADNRLENQLSVDYRLEIDSRRESNWIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB9</accession>
    <name>A0A0R3WRB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3292</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002196">
        <property type="protein sequence ID" value="VDM22330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB9"/>
    <dbReference type="STRING" id="6205.A0A0R3WRB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000330901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="253"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="435"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="660" mass="73184" checksum="B7EC2EA155C66845" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS28</accession>
    <name>A0A0R3WS28_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3552</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01002628">
        <property type="protein sequence ID" value="VDM22861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS28"/>
    <dbReference type="STRING" id="6205.A0A0R3WS28"/>
    <dbReference type="WBParaSite" id="TTAC_0000356801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000356801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000356801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="228"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM22861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000356801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48992" checksum="DFBE853D89FA61D5" modified="2016-01-20" version="1">MAILFLHPDLGIGGAERAIIDAAMAAKSAGYDVEIITNFHDIKHAFDETVNGSLKVTSVFQWLPRSIMGRFVALCAFIKMILASVWIVFARCKSVDLVFVDQVSAPLLVLKLAGIKTIFFGHFPDLLLSPHKSWIRRAYRYPLDFFEEFTTSMADTLLVNSRFTGAVFKQTFPSLKNRKIKVLYPVPNTNNLVLPRGIRVKISNTAYHPPDAGAALRSLHKILGVRPKLMFLSINRYERKKNIQLAFESFATLKENWSELVKDSPLSFSDVYIVHAGGYDVRVRENVEYFDELKQLLEDLKILEQAMLLRSVSSEFKSLLIAASSVLIYTPAFEHFGIVPIEAMYLGRPVIAMDAGGPRETLVHQQTGFLCPIPSADAFDNTEVAAKIAEYMCKFINDPELTTTMGKYSHAHVLHKFSTKAFQKKLCCIIENTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSC8</accession>
    <name>A0A0R3WSC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRP_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3654</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002806">
        <property type="protein sequence ID" value="VDM23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSC8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSC8"/>
    <dbReference type="WBParaSite" id="TTAC_0000366801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000366801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000366801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF80">
        <property type="entry name" value="TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transient receptor ion channel" evidence="6">
        <location>
            <begin position="311"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000366801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64212" checksum="32D04FE4E134206C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSD3</accession>
    <name>A0A0R3WSD3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynactin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3658</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002818">
        <property type="protein sequence ID" value="VDM23087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSD3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSD3"/>
    <dbReference type="WBParaSite" id="TTAC_0000367301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000367301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000367301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282505at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000367301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27648" checksum="91F96FCD95FDD129" modified="2016-01-20" version="1">MPLHLVRGKMAVIQEELLSLRNSESEKMELISENKTRALESSLQKEKDAAAKLEQDLIRAREKQSETTNLLTEVQKVEKVSCKWMTQLFKSVKSLGQGSKALHAHLKVLFPTEDRDDRDAASHSKTLSSKEVSTIVELLDALDSVQNAANACVVEARSAIPDLEAVELEMTKLGAEALGMANLPPNLNHAQSVEEYLVERILEVKNSEWSARQVAEMQKEEIARLNALNTTAHKTVRRKKPLFGHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSV1</accession>
    <name>A0A0R3WSV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3825</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003113">
        <property type="protein sequence ID" value="VDM23482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000384101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000384101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000384101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000384101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37241" checksum="959F45EC98C31DDB" modified="2016-01-20" version="1">MWIRESTAQMVRGGVYQYTDPTVPKNVRLEAINPYTVQLRWNPPLQPYGSVVGYIINWYLDNGEQRELNLLPTATSYVIAGLRPGQTISAHVRVVTQRGLVLKHKYTSDTSKVTEGGGKEEVKYVVTEGSALLLALTERTTSVDNSKIRDENRVALTTATLEINELFSNQGITANLEEEKDAKEEEDQGQGSEGEENIMGGLIKMFEATTGRSSAQILTDDPRSKTTREPTGAKTKTTKFNGVIITEKEKEVSATVEGSSTTPAITTVGMSNHTSAEEEEQRLKRTTTVVHGKASITISLLTTLRGLFVTPISIATATLTSKALPAAIALTLILLLLSSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSV6</accession>
    <name>A0A0R3WSV6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3829</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003119">
        <property type="protein sequence ID" value="VDM23495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSV6"/>
    <dbReference type="STRING" id="6205.A0A0R3WSV6"/>
    <dbReference type="WBParaSite" id="TTAC_0000384601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000384601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000384601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000384601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9437" checksum="E1A672CC3C426FA5" modified="2016-01-20" version="1">MSISAKTGKPKPPTKQPDVKEVAMETFKSMDVDKSGKVSFAEFKMAMEKKGGQKLSMSALKTFFDSFDKNKDGELSLEEIENLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSY3</accession>
    <name>A0A0R3WSY3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein tweety homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3858</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003172">
        <property type="protein sequence ID" value="VDM23593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSY3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSY3"/>
    <dbReference type="WBParaSite" id="TTAC_0000387301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000387301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000387301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000387301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43482" checksum="3D23E95E3F69B056" modified="2016-01-20" version="1">MQWISLANRTRKNLVCYFVDEVPADQDTSFLGQFLSLGLTTSVSIVVAAVLFIVLCLGCIICFCCCRNRSNTRTTNSSTPVVHTTFNGVNRTCSGEVIAPNVDPSSLLNGVGKSPDAFHSQILPPSIQQQQMVLPPAKSMGDLFHQTQLSPNSPMLRHFQEYPSTPQPPTSGSWSTQPICYPTAHHQQWFLQQQQTQSHQQQVSQQLPLSPQNQASNRASGWLEKRYMSDYFVDPLVNLTNTGSWCNSRFPYQHPETSPLVADGGIVYLGEIGGGSGSGGSRLASGTRRPRRRSGRAMDTQSSSSIGCGPSTRGAQSAEGAPRTASNSSHSIGPSWSSSRGTTANNPSANSSANICPHHHHHHHHRRRRRHGGGSGGSSGKQSTRNHSTNSSEKIAFPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTN5</accession>
    <name>A0A0R3WTN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS4110</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003685">
        <property type="protein sequence ID" value="VDM24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WTN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000412501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000412501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000412501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000412501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50073" checksum="6C3D4F703ED0EBC5" modified="2016-01-20" version="1">RECISIHIGQGGCQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSYSTFFSETGAGKHVPRAIFVDLEPTVIDEVRTGTYRQLFHPDQLITGKEDAANNYARGHYTVGKEMVDLVLDRTRKVADQCTGLQGFLIFHSYGGGSGSGFTSLLMERLSVDYGKKSKLEYSIYPAPQISTAVVEPYNAILCTHSTIEHSDCCFAFDNEACYDICRRNLDIERPTYTNLNRIIAQVCSSLTSSLRFDGALNVDVTEFQTNLVPYPRIHFPLVTYAPTVSAEKAYHEQLTVPELTNACFEPANQMVKCDPRHGKYMACCMLYRGDVAPKEVNASISTVKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRALCMISNTTAIAEAWARLDHKFDLMYAKRCFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGQDSVEGEGEEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU05</accession>
    <name>A0A0R3WU05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003969">
        <property type="protein sequence ID" value="VDM24482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU05"/>
    <dbReference type="STRING" id="6205.A0A0R3WU05"/>
    <dbReference type="WBParaSite" id="TTAC_0000424501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000424501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000424501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419198at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000424501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19321" checksum="4B046DAA0A984FBC" modified="2016-01-20" version="1">MSSTAEKLPLSDIFPLTYRPFGKHWYPAPRRPVTYLRTYYSANIQRCSSHTWSHALEKPIPEEHIDCRKLMQRYAFVHRCPIPEEERDNNPVGFCDEHLVDGSGRSVHKVRTALDGDEIDIPLYTVRHEAFRCCEDVYLKNGTTDAHTCALTSARSSFLFAYFGESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU24</accession>
    <name>A0A0R3WU24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA-synt_1c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4246</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003997">
        <property type="protein sequence ID" value="VDM24514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU24"/>
    <dbReference type="STRING" id="6205.A0A0R3WU24"/>
    <dbReference type="WBParaSite" id="TTAC_0000426401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000426401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000426401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000426401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14650" checksum="C72C0EF0FC24CAAE" modified="2016-01-20" version="1">MCDALKIRKPLVIDFSRLALQSTILSKRKLTWFVEQGLVSGWDDPRMPTVRGILRHGLTPEGLRQFILAQGSSKSTGTMEWDKIWAFNKKVIDPVAPRYTALSLSRGGVVPVRVKGQKTDETKQVTVLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU36</accession>
    <name>A0A0R3WU36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS4262</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004035">
        <property type="protein sequence ID" value="VDM24555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU36"/>
    <dbReference type="STRING" id="6205.A0A0R3WU36"/>
    <dbReference type="WBParaSite" id="TTAC_0000427601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000427601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000427601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275723at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM24555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000427601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16112" checksum="BF7005524B59CFD9" modified="2016-01-20" version="1">MGDCTLDTISVVKILRVSRVLRPLRAINRAKGLKHVVQCVVVAVKSIGNIMLVTFLLEFMFAVIGVQLFAGKFQYCNDEARFYKEECAGQFIKYDSEDPNLPELMERRWINYPLNFDNVPNGLLTLFVASTFEGWPALLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUQ4</accession>
    <name>A0A0R3WUQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004549">
        <property type="protein sequence ID" value="VDM25037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUQ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000449401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000449401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000449401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000449401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26030" checksum="99FDA2F1187734F7" modified="2016-01-20" version="1">MIEYAFLLTLIAFCSAGTCLCLYFFLKADPVLWGSRVVAVSNGTTPTMYFRFPNGSAIELQIGDSAAHALEIRDNKCYANQKMVGEPCELSEVRSVSARRQRPEDLILSWLTFSSCVHVVGSANITLFKIDRDSLLQVKKGKLPFSTTYLIPDCTLPDYGPEYLVRDENSGVTKFLGNFPRNKSEENTAYQWCRPTQCLVVTVDWTQGGESLATLRRQAYFPLFSLSSSTAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUZ3</accession>
    <name>A0A0R3WUZ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PI3K/PI4K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4568</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004783">
        <property type="protein sequence ID" value="VDM25205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUZ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WUZ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000458301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000458301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000458301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM25205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000458301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25086" checksum="8F7D89526DB2C615" modified="2016-01-20" version="1">MGLSATQPALLSLVSPEGQLYRVIFKIGDDLRQDQVVLQMIRLMDVVLKKEMFDLQLTPYVVLAASCRHGFIQFVKGVRLSDVNKEEGSILKYLQQRAPSSKDSLGLQPKVLETYIRSCAGYCVMTYLLGVGDRHMDNIMLTSEGQLFHIDFSFIFGYDSKLMAPEVRLTKDMIEAMGGAKTPTFNNFVNICVTAFLSLRRSAIKYFYPFFKLVIALVVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV84</accession>
    <name>A0A0R3WV84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004990">
        <property type="protein sequence ID" value="VDM25390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV84"/>
    <dbReference type="STRING" id="6205.A0A0R3WV84"/>
    <dbReference type="WBParaSite" id="TTAC_0000467401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000467401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000467401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000467401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41111" checksum="C40AF3EEC97DEFF7" modified="2016-01-20" version="1">MPPSHDLWSCFVDTKLRRFDIWERQVPKFKYNKNEPFFHCLVPTVDTVRYGSLLEQLLAARQSVLFTGGTGVGKTAITRSTLEELQKDEKYMAVYINFSAQTSSGRTQEMIVEKMEKRRKGVIGAPKGRHVVIFVDDLNMPKVDTYGSQPPIELLRQLQDFGGFYNRDKLTWIAVEDVTLCAACGPPGGGRNPITARLVRHFSVLAIPSPSELTLKHIFSAIVTGFMQDYPQGLRPLGDSIVGGAVEMYGRLAAELLPTPAKSHYVFNLRDLSKCVQGVLQASPLAVRDKASLTRLFYHECSRVFHDRLVDETDQLFFNTILSEIANKFFGEVWNNSVAKRFPNGSGLLSSIIYVKRISVNLKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWC3</accession>
    <name>A0A0R3WWC3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kringle domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5047</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006061">
        <property type="protein sequence ID" value="VDM26146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWC3"/>
    <dbReference type="STRING" id="6205.A0A0R3WWC3"/>
    <dbReference type="WBParaSite" id="TTAC_0000506301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000506301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000506301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000506301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23638" checksum="6D0E9D0637EC7377" modified="2016-01-20" version="1">VHHFSCTEAFGINPVVCLLSQVCVPWADVIRASVMKPGTPHLVIVNYTSPTNRTPVSSFDSSVANFRSCRNPEGRMAKPWCYVSAVSFTGNSLNSYLTTVGYRKAPCKVDMCDHSSHMGLPLDFGDECPSGFLTQVGKTASPQGEISTVYCVLSAKGLRNTEKGRFKNFCMFLLNQNRETCPKADVVLKESDPAFSSSPSSTPKPPPDFEVLANCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWG2</accession>
    <name>A0A0R3WWG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tubulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5087</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006209">
        <property type="protein sequence ID" value="VDM26231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWG2"/>
    <dbReference type="STRING" id="6205.A0A0R3WWG2"/>
    <dbReference type="WBParaSite" id="TTAC_0000510201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000510201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000510201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000510201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11100" checksum="81833930B1B30B15" modified="2016-01-20" version="1">MRECISIHIGQGGCQIGNACWELYCLEHGIQPDGHKPADKTIGDGDDSFETFFLETGAGKHVPRAIFIDLEPTVVDEIRTGTYRQLFHPDALITGKEDAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWG6</accession>
    <name>A0A0R3WWG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006225">
        <property type="protein sequence ID" value="VDM26242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWG6"/>
    <dbReference type="STRING" id="6205.A0A0R3WWG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000510601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000510601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000510601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10513441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000510601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16547" checksum="EFD06AB0689065E9" modified="2016-01-20" version="1">MVFVILGLDTWKPSENFDLTAVRSGEEELNVFEMMMTPRVNELQRIIAGQALLQTGSHLSTNSPFIAATSAVVTWVSSTAMATENPREQIASVLCASLVSAYRYFAASTAAAAASSSPLQFDALTEDSAISLAPTCPNTPAPPQHSFRKNFFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWI2</accession>
    <name>A0A0R3WWI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LsmAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5108</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006283">
        <property type="protein sequence ID" value="VDM26285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWI2"/>
    <dbReference type="STRING" id="6205.A0A0R3WWI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000512201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000512201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000512201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000512201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33005" checksum="F98D1F9DBBC7088A" modified="2016-01-20" version="1">MKYVRSTRRESPDGPFCLEDDKFIPLPEIQKIVVRNVNPVEVQKEELVLDENSCQLDDPDTCFQHYFTSNEDAEPFSLTSDEHFPPDQMFEVNRQKYNITSSYRENLEGYTVPLDKTDPEYKAKEEYYAKVAKEIEDNKCLASAWESLADGEIENEELKFSAVLQDGVQGRELKNTFNRAAKRGGRGNNRASLPRECSEAHKSTETKSQKPNSTSLRDQNKSSTDSATSKASSDAALEKGSPKSASHESPVTTDASTNSAVSPSKDLSKSVEAVGKKDDKKRGFLDPDAPEFKPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWS7</accession>
    <name>A0A0R3WWS7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuropeptide F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5202</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NPY family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006569">
        <property type="protein sequence ID" value="VDM26457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWS7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWS7"/>
    <dbReference type="WBParaSite" id="TTAC_0000521701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000521701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000521701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972427at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001955">
        <property type="entry name" value="Pancreatic_hormone-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020392">
        <property type="entry name" value="Pancreatic_hormone-like_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00159">
        <property type="entry name" value="Hormone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00309">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00265">
        <property type="entry name" value="PANCREATIC_HORMONE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50276">
        <property type="entry name" value="PANCREATIC_HORMONE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133108" evidence="5">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000521701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12999" checksum="C3ED1DFA77896F1F" modified="2016-01-20" version="1">MSIYLAVLLAFMVPPNNAGVHIDDRRLARAANALRRQLEQQQLDQLQYRSPLLHSLLDVPVGAMDDGLTSTDYAKRADPLSIVNPPESVLNNPAALRDYLRQVNEYFAIIGRPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXK7</accession>
    <name>A0A0R3WXK7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5481</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007691">
        <property type="protein sequence ID" value="VDM27070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXK7"/>
    <dbReference type="STRING" id="6205.A0A0R3WXK7"/>
    <dbReference type="WBParaSite" id="TTAC_0000549701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000549701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000549701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000549701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18479" checksum="34E25B200FC7129C" modified="2016-01-20" version="1">MASRQLHGKATVVRTLSLRRILLRALRITFWCCVHKYIICSVNFIDVLAAPFERILKGRDALIDGSILCFAAYMFVVRFNVFYVIFYNLSRLIGDLQQLLLSPAFASNTTQLVKGNPNAERIWKEASLIERWLKVEVKTECLMPEGPCCVMVAFTSSEIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY81</accession>
    <name>A0A0R3WY81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5706</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008647">
        <property type="protein sequence ID" value="VDM27490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY81"/>
    <dbReference type="WBParaSite" id="TTAC_0000572101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000572101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000572101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000572101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="8441" checksum="28FA5C88AB565001" modified="2016-01-20" version="1">MEAAAQIAAFICSDWTGVSQVQQSKLFNCVAPLHVAVVNAVLSGIGEVAPDEVGDGLTSSAVAATEASRHDGVRGGGEGEASNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYK1</accession>
    <name>A0A0R3WYK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009249">
        <property type="protein sequence ID" value="VDM27756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYK1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYK1"/>
    <dbReference type="WBParaSite" id="TTAC_0000584101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000584101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000584101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000584101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12541" checksum="D5139400B0EFED01" modified="2016-01-20" version="1">MEPWRRSHAELFALLQSRCLEFRMQDQFVSLGWFSPSQMFVLDEYCARYGVRGCHRHLCYLADLLDRAEHGVMVDPALVHYSYAFCSRHILGNTYVHSSFTPLDSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYM1</accession>
    <name>A0A0R3WYM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5844</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009334">
        <property type="protein sequence ID" value="VDM27793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000586101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000586101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000586101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000586101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7802" checksum="0C898D5ECD012C63" modified="2016-01-20" version="1">MSEAGTRTVVPTSPLMWALEEVMLCSSPSFPPSLLPYLPHLAIAYDIFEEHMSPLHITCHPTTDTPSSCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYS0</accession>
    <name>A0A0R3WYS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AKAP7_NLS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5895</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009590">
        <property type="protein sequence ID" value="VDM27908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYS0"/>
    <dbReference type="STRING" id="6205.A0A0R3WYS0"/>
    <dbReference type="WBParaSite" id="TTAC_0000591001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000591001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000591001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000591001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31050" checksum="7E99F0B8F5516CE3" modified="2016-01-20" version="1">MDSFVMDRTEDILSPLLMKIGNRLYRKNPTKSTNSTLVPVGCLENECEPDEDAINDDFGSDQTCYFVEDIHSESGGCVAKLYVPRVFYSRIIGTRQVKKHELESEFLCRLTFPSPQSTLSHIKIFSKSEAGILGVVRRIAWIISESRSKMNPTHFVCIPLISNEIKGSYLTFKKDVLKHAESDAVGAFRGIDDDLFVSEHKLHFTLATLFLADQKEVRLASQLLTSFMDHTDEGKTFDRSPLCLTICGLGCMNDDPRSAQVLYLSVNPIDALLSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X050</accession>
    <name>A0A0R3X050_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6459</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X050"/>
    <dbReference type="STRING" id="6205.A0A0R3X050"/>
    <dbReference type="WBParaSite" id="TTAC_0000647401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000647401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000647401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="31"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000647401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="864" mass="95297" checksum="ACA75B921ABE785E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X170</accession>
    <name>A0A0R3X170_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CULLIN_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6911</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020331">
        <property type="protein sequence ID" value="VDM31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X170"/>
    <dbReference type="STRING" id="6205.A0A0R3X170"/>
    <dbReference type="WBParaSite" id="TTAC_0000692601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000692601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000692601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="278"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000692601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="633" mass="73675" checksum="24937229C67DF047" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1B0</accession>
    <name>A0A0R3X1B0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1B0"/>
    <dbReference type="STRING" id="6205.A0A0R3X1B0"/>
    <dbReference type="WBParaSite" id="TTAC_0000697301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000697301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000697301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972865at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000697301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25938" checksum="01011F077A7DCEA6" modified="2016-01-20" version="1">MLTNISTETNSGAFKICVDGYTYSHTCDLYRNICYCREGDPRCGDERYFNGHRADSDSIIRYFAECQELTTKCNWAVQQRYFKYQFILWLQQLLRSTNYGTDPRNVLLRPRSEHDWLALDSLLAKQIGRNGENAGPILSFVFCELDVDKSGMIEERELAMLTQVALPTLACLEIFLGNCISGRTISRDAWFNCFEIDSRKPSLFSFMAEVMCETCLSAIHLYYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1B6</accession>
    <name>A0A0R3X1B6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6968</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020335">
        <property type="protein sequence ID" value="VDM31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1B6"/>
    <dbReference type="WBParaSite" id="TTAC_0000698301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000698301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000698301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258395at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133107" evidence="3">
        <location>
            <begin position="24"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000698301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="579" mass="64605" checksum="EE877666ED1A8F70" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1V0</accession>
    <name>A0A0R3X1V0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020352">
        <property type="protein sequence ID" value="VDM31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1V0"/>
    <dbReference type="WBParaSite" id="TTAC_0000721501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000721501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000721501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10287404at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000721501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15215" checksum="281328DEB1815F94" modified="2016-01-20" version="1">MTEVLEDGYEKAYSAINLFHFPSTINQADSPLQESHVIACVALCSIAQIGLLIWFILSFRLRQFGHASVEVGRSRCRNPPVNALRTSETDKDTFYYRDPTTGNLIVRLDFLVDLAHLLKNFGESLADYKQHHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1Y6</accession>
    <name>A0A0R3X1Y6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7242</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020355">
        <property type="protein sequence ID" value="VDM31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1Y6"/>
    <dbReference type="STRING" id="6205.A0A0R3X1Y6"/>
    <dbReference type="WBParaSite" id="TTAC_0000725701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000725701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000725701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000725701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14725" checksum="40B79374917E55D2" modified="2016-01-20" version="1">MLILRNRIFEHYCLYCARNGRLIPVGLVLGFYVDVVVKRWWEQFRLIPWPDEMTMLLSAHVLDDSEAARQNMKAVLRYINLSYILAFRTICSRVRKRYPVDQSLLADGKTNRIRQNLRRHCAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X207</accession>
    <name>A0A0R3X207_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ectonucleotide pyrophosphatase/phosphodiesterase family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7270</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X207"/>
    <dbReference type="WBParaSite" id="TTAC_0000728501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000728501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000728501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133127" evidence="3">
        <location>
            <begin position="22"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000728501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63782" checksum="7063EF99C69F4DD2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2E2</accession>
    <name>A0A0R3X2E2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RuvB-like helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7438</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2E2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2E2"/>
    <dbReference type="WBParaSite" id="TTAC_0000745301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000745301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000745301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000745301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="456" mass="50471" checksum="F17C36AD9B0F1873" modified="2016-01-20" version="1">MRIEEVNSTTKSQRIAAHSHVRGLGLDENGEPLQNAAGLVGQVAAREAAGIVVEMIRSKKMAGRAVLMAGPPATGKTAIALAISQELGSRVPFCPMVGSEVFSSEIKKTEVLMENFRRAIGLRIKEVKEVYEGEVVELTPVETENPTGGYGKTISHVIISLRTVKGVKQLKLDPSIYESLQKEHVEVGDVIYIEANSGAVKRQGRCDVYTAEYDLEADEYVPLPKGDVHKKKEVVQDVTLHDLDIANARPQGGHDIVSMMGQLMKPKKTEITDKLRKEINKVVNKYIDQGMAELVPGVLFIDEIHMFDIECFTYLHRALESTIAPIVIFATNRGKCPIRGAEDIISPHGLPLDLLDRVMIIRTMPYTFAETLAILRIRAETERLKVSEEAFQRLATIATESTLRFGIQLLTPASRLARLTDSEEITPDHIIEVSCLFLNAKQSAKVLAEHDSQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2H9</accession>
    <name>A0A0R3X2H9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020376">
        <property type="protein sequence ID" value="VDM31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2H9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2H9"/>
    <dbReference type="WBParaSite" id="TTAC_0000749301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000749301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000749301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277913at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000749301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15577" checksum="D444202A5EBEB110" modified="2016-01-20" version="1">MRLMEVVYCGLGGYFQMAHPAMMEEIISWQDSSGCFKAVVANEDKREFKDDLEVDRPLEDGCLPHLTSMAVNALAMHLYRFATEVVFVPDFHSVLQMETIFLNNAQNLPDFVAPETSPALWSQQENRPYAFVPDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2V3</accession>
    <name>A0A0R3X2V3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Triosephosphate isomerase</fullName>
            <ecNumber evidence="8">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7628</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2V3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2V3"/>
    <dbReference type="WBParaSite" id="TTAC_0000764301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000764301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000764301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000764301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27123" checksum="73B3A60B2D92776F" modified="2016-01-20" version="1">MARKLFVGGNWKMNGSYGHIDSFFDTLKKADTDPNADIVIGVPACYLKYAQEKAPKGIKIAAENCYKVSSGAFTGEISSEMIKDCGCEWVILGHSERRHIFGESNELVGEKVKHALDSGLNVIPCIGELLSEREAGKTNDVCFSQMEAIAKNVPSKEAWNKVVIAYEPVWAIGTGKTATPAQAQEVHKVVREWIRKHVDAGVADRVRILYGGSVTASNAKDLGAQPDVDGFLVGGASLKPDFVTIINARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Y1</accession>
    <name>A0A0R3X3Y1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8069</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020440">
        <property type="protein sequence ID" value="VDM32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Y1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Y1"/>
    <dbReference type="WBParaSite" id="TTAC_0000808401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000808401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000808401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="117"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="299"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000808401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="54398" checksum="A22B30EE94E7F4AD" modified="2016-01-20" version="1">MQVYANPISNLVVGVKLFSLTSSGLVLAAQPFLFSKFTTLAGFAPFFVSSLSFAALTPILLHVLTRPCVFKIIYDPQTDRFTAYTKTIFLRPKKVEFRLEDVSYSVASLCFANMILRPFVDMKQVIVHAGKGGDGCIAFDRTFCNPYGGPSGGDGGNGGHVIFQADSEVIDFSSLDSVLRAADGSRGSGDNCHGSNGKNLIVKVPLDTQVHLLASKEDSTVSAHRADTSSLLCTLTAQSDTLVAARGGAGGRGNAFLASSVQIRRAEALPRIGEAALRFAERGARGQSRRLLLRLTSFTDVGLVGGPNSGKSTLLRRLTRARPRVAPHPFTTLRPHVGTLEIPLGSGGKGNGDGVKLSIADLPGLIEGAAKRNAGLGAQFLSLIEGCRFLIYLVDVGTFFTNGSRSFSLAEVTAHFASQLGVLYNELKLFNPRLVDDTERTSLVVGTKVDLVVPSSSKHETLHKLSTCLSNAAKQTGLRSPTVLLISARRGDNVEQLVEILGNMRFKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X490</accession>
    <name>A0A0R3X490_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nbas_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8198</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020462">
        <property type="protein sequence ID" value="VDM32710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X490"/>
    <dbReference type="WBParaSite" id="TTAC_0000821301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000821301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000821301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19988at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029145">
        <property type="entry name" value="NBAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15492">
        <property type="entry name" value="Nbas_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuroblastoma-amplified sequence N-terminal" evidence="1">
        <location>
            <begin position="157"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000821301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2367" mass="265901" checksum="989460C5DE240067" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X495</accession>
    <name>A0A0R3X495_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8205</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020464">
        <property type="protein sequence ID" value="VDM32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X495"/>
    <dbReference type="WBParaSite" id="TTAC_0000822001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000822001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000822001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266374at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133181" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000822001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15590" checksum="1E734AF2420F2F88" modified="2016-01-20" version="1">MLWVVAALHLAALVVAGLDEIEPIVQRHEYPLGGVIPLTPKVLQSKEVEERVERALRQLSRRNGGLMTYRIIHIRSGTRQVVNGFKYVFVVEVESLPTEEGAGTESVSEVYRVRIYEPASRGAKRRYFFKKIPTNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X510</accession>
    <name>A0A0R3X510_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SLC3A2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8514</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020521">
        <property type="protein sequence ID" value="VDM33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X510"/>
    <dbReference type="WBParaSite" id="TTAC_0000852901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000852901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000852901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9937541at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000852901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32914" checksum="F15742395088CF2D" modified="2016-01-20" version="1">MRLELVITHNAYDSMSKQRLIRRVTGNPRSLLPANGRSACSLAHTHARMHAGAEARRSHALPRERIASSTLRPPQGNDDKEEKRSRRRRRKASNKDLYPRTLKEAGESEERWTSKCREAGMQASGEDVVSESVPQGVPFAGLSVGLLHSLQWVRRIEALVGQKRLLLGVSWSAGSLALLLLFCAIAMDSWLFTVEREPDETSNATFLITLHSGLWRVCKKNLFMKDVGKNTQWNLSWREFSPRAFYLTTGEPVDPLKLTQLLATASTLARQADCQLLDGCDPSQMRRAFDMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X583</accession>
    <name>A0A0R3X583_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Armadillo repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8592</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020540">
        <property type="protein sequence ID" value="VDM33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X583"/>
    <dbReference type="STRING" id="6205.A0A0R3X583"/>
    <dbReference type="WBParaSite" id="TTAC_0000860701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000860701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000860701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000860701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="891" mass="98164" checksum="CF6E9C6C1F844913" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5P5</accession>
    <name>A0A0R3X5P5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">53-BP1_Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8787</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020588">
        <property type="protein sequence ID" value="VDM33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5P5"/>
    <dbReference type="STRING" id="6205.A0A0R3X5P5"/>
    <dbReference type="WBParaSite" id="TTAC_0000880201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000880201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000880201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20383">
        <property type="entry name" value="Tudor_53BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015125">
        <property type="entry name" value="53-BP1_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09038">
        <property type="entry name" value="53-BP1_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tumour suppressor p53-binding protein-1 Tudor" evidence="2">
        <location>
            <begin position="411"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000880201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1100" mass="120782" checksum="C3687CA2DB7B8B8F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U4</accession>
    <name>A0A0R3X5U4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8843</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020604">
        <property type="protein sequence ID" value="VDM33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5U4"/>
    <dbReference type="WBParaSite" id="TTAC_0000885801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000885801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000885801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00182">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF204">
        <property type="entry name" value="SPADETAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="6">
        <location>
            <begin position="283"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000885801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55350" checksum="DF9C2E283E20EDC3" modified="2016-01-20" version="1">MDEYHAWSSQVNGGYEENVNHCLPPIDTQHFANSSNYLHERQLLPDHQMPLEYQESSFNPSSYQPSFQQEAASYLNNANAVINNPHDERNAYLSTQRCELNYNECEYFKPNMNASEYNQNLQVSEPINGVYGLQQDQPFQQYQSQLYGASDTQEATLSVTGSNSLQFDTGLHYTCQTPNSLFNTSQMVNRTEILEEGGYKDSPPTTIEDFGAAGSQSQQASSTLQSGQDQDLYTVLLVIAQGVPKVFPSCLVSQRGQFSSICVAGADFKHPTLGERSTITLRLRDREIWQMIWPHKMEMITSKNGRRIFPTLSISIEGLEVDELYTIFMDLVPKDQFSYRFQSSHWTPHHAHNSPSQSQSSCIYVSRRLREKGSQLMISGVDFTQVKITNNAATAISRKQIFARSMQIYQPRYHVVRHLASKEAVVRQSFVNAWQGNFSPHVEHVGTYIIPETEFVAVTAYRNKHISDAKIEANPYAKAFRNRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5Z5</accession>
    <name>A0A0R3X5Z5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8898</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020622">
        <property type="protein sequence ID" value="VDM33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5Z5"/>
    <dbReference type="STRING" id="6205.A0A0R3X5Z5"/>
    <dbReference type="WBParaSite" id="TTAC_0000891301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000891301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000891301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000891301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22356" checksum="717C8DC53C08D9E5" modified="2016-01-20" version="1">MDGDIKYNMRMLLIIRVEGIRRGTVCSVFILQELVLLHDFLGGIEGLQHLRPRIQREAALQEAARLARLMRVRGESLLFRRGDPASAWFILLSGCVLMDHSMFLPRNCFGTRLNGSQVRQQDCFVLEDSDLIVIAYLERDPPQPPPPPSAASQRTHLRPASHKKALLVGLVPIAGLASVHALSPSTLPLSIVELFTTTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6I0</accession>
    <name>A0A0R3X6I0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sjoegren syndrome nuclear autoantigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9100</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020680">
        <property type="protein sequence ID" value="VDM33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6I0"/>
    <dbReference type="STRING" id="6205.A0A0R3X6I0"/>
    <dbReference type="WBParaSite" id="TTAC_0000911501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000911501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000911501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000911501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13134" checksum="B0DD97D00A1E120F" modified="2016-01-20" version="1">MSQQGAALQNYNNELVKCFEDLCKRREDIQRQIHVDETEKAKLQRDLSQITEKLNRVNDSLQKKLVLRNELDRTIAESEAAYMKILESSQTLLCVLKKEGQGIMQRAAAKNVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X768</accession>
    <name>A0A0R3X768_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9372</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020785">
        <property type="protein sequence ID" value="VDM34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X768"/>
    <dbReference type="WBParaSite" id="TTAC_0000938701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000938701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000938701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000938701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14154" checksum="69DB33C544D81436" modified="2016-01-20" version="1">MGYALSGCPTLVLMLLKIKLEELWIINKKCLLQSRFVFGRCTRLILPIDGLLISTLLQKRSSPPSPWMPACPTVRRRGLFVRDGCTSLNLMSKRIDCLAPHLISAAFEGAERWIAWVDVPTDAGIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X856</accession>
    <name>A0A0R3X856_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9716</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021001">
        <property type="protein sequence ID" value="VDM34616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X856"/>
    <dbReference type="WBParaSite" id="TTAC_0000973101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000973101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000973101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000973101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16577" checksum="59A84AADB14F57B9" modified="2016-01-20" version="1">MSSCLSLGDYCDGRVRATPTPRSFDAYSSTSSFHRTQLSTLTSPSTINPFHPFIPLNFTTPFVSQLLFRLLRHLHLCFSSNPIRVCTSILTVHNAGCVHSQPPTSHLHHRLLLLPLPLTSACIPLPSPNGLCLWALQQDGDAGGGEGACNVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X859</accession>
    <name>A0A0R3X859_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3700 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021003">
        <property type="protein sequence ID" value="VDM34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X859"/>
    <dbReference type="WBParaSite" id="TTAC_0000973401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000973401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000973401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000973401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21416" checksum="A9F8A5EB1F68A846" modified="2016-01-20" version="1">MNEWGMVSAGEVGVTGGNDGSLVLNLLEMSQPGGEAYVLGDGSVSCVGAVSTFPKVKLPSSLARHFFPSDTYFHYSSDVEQSFLLGNESVMVSRAMRDVFIGPEGKIFTIFESGDIALLRSDNDKASELTPLQPRLSPMLSERVSKEAEFIDNDGVHLRQDRLFPGYCVSGVHRESRRFALGGRWGCLGIYEIIDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X892</accession>
    <name>A0A0R3X892_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS13_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9752</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021025">
        <property type="protein sequence ID" value="VDM34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X892"/>
    <dbReference type="WBParaSite" id="TTAC_0000976701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000976701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000976701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10466287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000976701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="753" mass="85198" checksum="1BFBD4458ED6620F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8L5</accession>
    <name>A0A0R3X8L5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9875</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021125">
        <property type="protein sequence ID" value="VDM34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8L5"/>
    <dbReference type="WBParaSite" id="TTAC_0000989001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000989001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000989001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000989001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25968" checksum="F6254E9FAB99F030" modified="2016-01-20" version="1">MLESTQPTRTMFACERKDLLVVQLDTSLVSLCNCTLGQSHWQCLEIWAFLYIRCRLALEPHVYAQRLSTAILSSLRRPASSDVPGKLRVLWKAREWEGRAAILHPPPLISIGLAVTPNNGQKCRQSNEVEEDGDEKEEEKEDFRREQRLVMSEEWILEDHSDFIPTPNHGLLHLSNALTIFAWWTLGVSTLLSLFDNVDLAAQSLQSSTVRTRFTGHLNARQDFLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X993</accession>
    <name>A0A0R3X993_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10100</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021311">
        <property type="protein sequence ID" value="VDM35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X993"/>
    <dbReference type="STRING" id="6205.A0A0R3X993"/>
    <dbReference type="WBParaSite" id="TTAC_0001011801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001011801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001011801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001011801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="764" mass="86587" checksum="4FC66EE5C4D79195" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9F4</accession>
    <name>A0A0R3X9F4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10164</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021376">
        <property type="protein sequence ID" value="VDM35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9F4"/>
    <dbReference type="STRING" id="6205.A0A0R3X9F4"/>
    <dbReference type="WBParaSite" id="TTAC_0001017901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001017901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001017901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001017901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31300" checksum="8477D94C627DD40F" modified="2016-01-20" version="1">MPNSRKPWLLSRVCETIEGAGLMIGVVPASVVTLRKPPTTVLEKETYSAELYKRRRRLKEIRAGFKRFFAFLFSQIGLSLLVIGYTIIGGMIFRAVELENEKMVKVKGKELRTALADQFSGEIIPMNRKRSELSVRVKKNQMKSKIRRPRIFGGRTESEFARLRQWLHVIAYTLRHKTRQELHSSLRKLVKMMDREGWNGEDAMDDLKWSWEGSILFAVTVITTIGYGHAVPKTNAGKVLTIIYALVGIPLVFLYLTNIGDYLASLFRSLYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB47</accession>
    <name>A0A0R3XB47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10757</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022197">
        <property type="protein sequence ID" value="VDM35737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB47"/>
    <dbReference type="STRING" id="6205.A0A0R3XB47"/>
    <dbReference type="WBParaSite" id="TTAC_0001077401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001077401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001077401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001077401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14276" checksum="6A2774D32D66B7F3" modified="2016-01-20" version="1">MRGWLGIRADDSMWCGQRGTVGNAKPPTISSATQRLIVTVGTIATHHFQPHIAPPWYTIHKSVFLSGGDGAGGINCNARRRPRSLVVPGDSRVMCNLAHRLSCSAFCFIPEQHQAELLTTTFSCGPSTFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC01</accession>
    <name>A0A0R3XC01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022836">
        <property type="protein sequence ID" value="VDM36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC01"/>
    <dbReference type="WBParaSite" id="TTAC_0001107801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001107801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001107801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001107801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7113" checksum="A6FF4DD21A72E974" modified="2016-01-20" version="1">MQCWRISAIRQTSELLRCLLCGRVNLDSGSGPGVMAHVLVGDYHSSGFDFYPEQIWGPVFLGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD42</accession>
    <name>A0A0R3XD42_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11452</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024251">
        <property type="protein sequence ID" value="VDM36555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD42"/>
    <dbReference type="STRING" id="6205.A0A0R3XD42"/>
    <dbReference type="WBParaSite" id="TTAC_0001146901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001146901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001146901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF175">
        <property type="entry name" value="ANNEXIN A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001146901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14538" checksum="68ED12D36E07D186" modified="2016-01-20" version="1">MLHDYNADAERIYNACKGLGTKEEDIIQVIGKRKLPERHQIRLAYFSKYNKDLLDVLDSELSGDFGELARNLFLGPIQILAAELYKIFKKTGSAGGDVNDIICCLSPTEITALKTAYLEELFVGAIHETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD75</accession>
    <name>A0A0R3XD75_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024412">
        <property type="protein sequence ID" value="VDM36652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD75"/>
    <dbReference type="WBParaSite" id="TTAC_0001150201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001150201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001150201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001150201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="3897" checksum="04624507E40D9B52" modified="2016-01-20" version="1">MKVEVATKKLHLLFIAISTPDAAPSSGQIVVRDTGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDJ2</accession>
    <name>A0A0R3XDJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025537">
        <property type="protein sequence ID" value="VDM37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001161901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001161901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001161901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001161901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19402" checksum="C02FD59F17E17337" modified="2016-01-20" version="1">MLTTKIGARGDGFGGIALLDYLHCSFVDPQTYRLSWKAFNMTKQHANRIAVSTIAVDLGGDLVVKIVDFSLGEVSLGGLLPDKPYHIRLEVFDNEVSVWLYNATMQTPPIGESLLVNADAFVGEVKGFRTACRKLLFARMLRRAQQTYYHRIVCPSKVAKAVFVFWHTKPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDE8</accession>
    <name>A0A158RDE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS514</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000047">
        <property type="protein sequence ID" value="VDM16566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000051301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000051301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000051301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1727"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1769"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2314"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000051301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2969" mass="327703" checksum="0EBE1735F27047CC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE53</accession>
    <name>A0A158RE53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6648</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020313">
        <property type="protein sequence ID" value="VDM30885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE53"/>
    <dbReference type="STRING" id="6205.A0A158RE53"/>
    <dbReference type="WBParaSite" id="TTAC_0000666301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000666301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000666301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000666301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1220" mass="138737" checksum="1E5086B43B00BB32" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REH5</accession>
    <name>A0A158REH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7295</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020360">
        <property type="protein sequence ID" value="VDM31655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000731001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000731001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000731001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <sequence length="269" mass="29838" checksum="781767C3E6101B03" modified="2016-06-08" version="1">MVGLLFVIFLRLSSCAANIENTGETLLDTCGSCDESKCPPITMCPVGEVKDYCGCCLVCGLEQGHRCNTRQELHDMFVGRRRHGYYGACGKNLECQPRTDVDEDSLGEENICVCTKPGRFCASNGETYSACELEAVQAKSFGEVFLISYDDCKSEPRIVAASESQRVPGGNKTTFWCEIKGYPLPTVTWYYFAPGGSYEAILLPGDSDEMSVSLRGAPPGRRIISHLQIRRFDIKYEGIYQCYVENDLGSDRHNITAIYAPPEARPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF45</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">TTAC_LOCUS8762</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="451"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="602"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000877701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="890" mass="97278" checksum="64062F23BCB41F8A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EBT3</accession>
    <name>A0A3P7EBT3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl-hydrolase family 116 catalytic region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000691">
        <property type="protein sequence ID" value="VDM18763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EBT3"/>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="212" mass="23507" checksum="0C5B7DBA7E3A0D2B" modified="2019-02-13" version="1">MYATHDMLKHAGDKSFLGAVGHWSEVNDNLSGLLKRAKSAYHDQLWGGEFYRYDITTPSNARNNSVMADQLSGYWFLRTGGAPIDAILPVDAVMGTLKTIVRLNWLSVRNGKLGAINSVFSSAKKDNTNMQAEEFWVAVNYGLAALLILHGKSSEGFGLAGACFEHVYNQLGLHFQTPEAFTKEATHRSLGYMRPLAIWSIQRAIEMTHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EG50</accession>
    <name>A0A3P7EG50_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001819">
        <property type="protein sequence ID" value="VDM21781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EG50"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018259669" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9859" checksum="112E7CB1A84FD978" modified="2019-02-13" version="1">MSLLLSYIRMMRWMVVVVVVAARRMEGEEWQCFDVVAPLKRCAISLRVIPMPLPICRCWERSVPSPSSALSSPLVLVSPVHSPSCLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EKR4</accession>
    <name>A0A3P7EKR4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WDR36/Utp21 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003127">
        <property type="protein sequence ID" value="VDM23511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EKR4"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="130" mass="14488" checksum="0954CBE2D4FF9063" modified="2019-02-13" version="1">MQDKMTTLSGLPPSFFTAFLQLDAIKKRNAEAMKVTDDTGPAQLPFFLPAIETTTGMTWLDDEEEEKPVLEVSKKVMDVATDSKKNKLRRSKMTMEELVLDPGSSIVNSLLEAGSLKDPLNDEICEFVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FIR3</accession>
    <name>A0A3P7FIR3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Daxx histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020402">
        <property type="protein sequence ID" value="VDM32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FIR3"/>
    <dbReference type="OrthoDB" id="7492809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766:SF7">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Daxx histone-binding" evidence="2">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="592" mass="67319" checksum="B3861330E7B44EFD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FPT5</accession>
    <name>A0A3P7FPT5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022013">
        <property type="protein sequence ID" value="VDM35643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FPT5"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43914" checksum="6ED4C484F05EE8B4" modified="2019-02-13" version="1">MDATVVGCFPEEQQQIFIKDNASAGVLRVVKLEEPDFPLEFYYMRETRRRVVIAFRSGRISIDVRPSICPALALTHSVGRFSCLLMPFYSVGLLNLLNYGLLPQQTLGSKRMKNTRAPHSSLNAPYRLLSPSSPPSLLRQEEELVALYLSLELLWIAEGLHNHAKIIHGDIKPDNFRINDRFPFLNVSMLDENVANAGAEADGVASDNFTSCLMSDRCTKVLVLLDFGLCIDMARLPPGTVFTVGKKRSFPCIEMLTGQPWTYQAGPGITHRLSIPHYCLLFSEPQLDLFNIAGVIYTLVFKHYMEVECFNGEWRPKVLPRSNRVYRAIEVWRNIFSALLNVRSCAPADYPDLAALRAQCEAFLLEHAAAYNVAAEKANAIICHLSLGFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G121</accession>
    <name>A0A3P7G121_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021282">
        <property type="protein sequence ID" value="VDM35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G121"/>
    <dbReference type="OrthoDB" id="10006326at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF17">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00220">
        <property type="entry name" value="SYNAPTOPHYSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19054" checksum="BA1CE19369236368" modified="2019-02-13" version="1">MDSLEVPASIRRLNFPLYGDFSSGAQFYVFTGVMASLYCIGILVLYTVFIDKYGSNVLYRKADFVLSIFIVILWFIAATVWARHVDHLKRYTSEEVIKRELCTQENCQIEAPQGYAGLNISLVFGFSNVALWAASLWFLWKETPWFRNASDRVQQDSVLSEVDGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G489</accession>
    <name>A0A3P7G489_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000200">
        <property type="protein sequence ID" value="VDM17568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G489"/>
    <dbReference type="OrthoDB" id="6241714at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="279" mass="31353" checksum="0F71BDC566BB862A" modified="2019-02-13" version="1">MQHRRYCTLSGIFRVQRPYNSSNVSAVCPSTSSPKKDQKGFLDIDDSVASVIPVDADPSQVTKSVSGLHRCRSMSDIRRTRVTLTDSEIRLRSNLAAWTFLLEHSRKAVENQNKQEETLRKSITEAHDREAWLKKWLRVQKSTELQIKIYQRLVELLEGESGMTDLLRRFYINHLLPVSDRLPLEGLTLGDDFQGHLAAASQAGEEFVAAAAGDLNALGIIASQLTEMSRAILSSTSWLGNKEVVTKLTQACRLCLRLASLRTYRLQREMAQRLGAIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GS20</accession>
    <name>A0A3P7GS20_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005067">
        <property type="protein sequence ID" value="VDM25428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GS20"/>
    <dbReference type="OrthoDB" id="10639652at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="167" mass="18391" checksum="1F2D0C81A06046A0" modified="2019-02-13" version="1">MTLLGWWTQKLGTPALSMSHSSVAPTSTPPFMRFLWPPLPPPSPLPLTALPIAPPTSNATVSQVFGCPAKLLLKLPELLHGFVLQHGWTNSQCCRPTACTLLLRRLEPWLSVKSKAALAKSLLAMLQLRGEVPAFLAALVLSEVQEQGEPIFRLLFQLSFWECFCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GT15</accession>
    <name>A0A3P7GT15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005527">
        <property type="protein sequence ID" value="VDM25788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GT15"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="74" mass="8713" checksum="59661F1D3378E844" modified="2019-02-13" version="1">MSDSKQDNKVEFVMDAVWPLLFISLLTVFYIIYKIPIVRYYVKYFAFGLILNVGSVFYTIIFLIKGKPSFTNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GVW7</accession>
    <name>A0A3P7GVW7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005889">
        <property type="protein sequence ID" value="VDM26022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GVW7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25837" checksum="44842F949B3BCBC3" modified="2019-02-13" version="1">MVCAFQSKRTALHYAAQTNVESVITLLTYNKGLLKCVDSVSLDSPNPSPSMPAGMRIIPEVKADSAITIHPPLMLAFLPFIHEPSASDDLTPLQFIQHEHRQSMYHFLEFHTELYSAGEEGGLTSNGGNKKAIHLRRLIEAPLILDSYVCTFLPLRRESICEKCNTRGYNHEKLAENADFMKVIASRELGCVRRPTNAFGQFEKTFSPIVSQVSHSSTFRGACFLSSDVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H218</accession>
    <name>A0A3P7H218_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010230">
        <property type="protein sequence ID" value="VDM28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H218"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="135" mass="15636" checksum="C5057A1D6952538B" modified="2019-02-13" version="1">MLLLLLLLLLLLFLLLLFLLLLLLLLLLLLLFLLLLLLLLLLLLLLLLLFLLLLLLLLLLLLLLLLFLLLLLLLLLLFLLLLLLLLLLLLLLLLLLLLLLLLNVCLYCLSIFLSAPYFFSCCFCFTCNEYAKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H9K6</accession>
    <name>A0A3P7H9K6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020365">
        <property type="protein sequence ID" value="VDM31728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H9K6"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306:SF0">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="73308" checksum="AF8C212116F9975E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJT0</accession>
    <name>A0A3P7HJT0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021875">
        <property type="protein sequence ID" value="VDM35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJT0"/>
    <dbReference type="OrthoDB" id="6257650at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26676" checksum="A4AF1160E0D97BFA" modified="2019-02-13" version="1">MVNALQQSPVPLCFCFSYRMYRKNQQTGFPALITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVSVLNICSSDELFTEDNEDDSEFCISFFLEENESVLELKGLTPNGMLPIGLLSEGRENLKQSALAPHAKISSFAEAKAIDKINERMPPAQALANPKDCVAAFIKAAEDSTNAPSTVKNATATTTTTTTATTTSTTSAPTAKKGSGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HM06</accession>
    <name>A0A3P7HM06_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023879">
        <property type="protein sequence ID" value="VDM36368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HM06"/>
    <dbReference type="OrthoDB" id="9991441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018307624" description="Sushi domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="4">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM36368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11758" checksum="F002B6FE807D3B47" modified="2019-02-13" version="1">MYSSVLMVLRAFILSVHCSRPRVPEGMEIYLVGARGRWPFDSKQILPTHGAVVEYSCRKDDHRIEGPKYTFCIDGAWSPEETPICTKMTHDLIPPSWLFYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI31</accession>
    <name>A0A0R3WI31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI31"/>
    <dbReference type="STRING" id="6205.A0A0R3WI31"/>
    <dbReference type="WBParaSite" id="TTAC_0000022901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269791at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18294" checksum="BDABD2F89B733874" modified="2016-01-20" version="1">MTAEHSESVPSILRRITPPRLSDPPPGGGTTAARHSTYTTSRGHRFASAAAAIYNEPCDARLSGSGGGGSTFTSKRAAVRRASLAASIYCDTEHHRQGGFQLPSSPQGSPDSLRLNSANYLREGSGPTGFNATNGRKNGATGHTSQYWKEHDSGSSSLSNSRDVFSHINPHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WII4</accession>
    <name>A0A0R3WII4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS410</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000034">
        <property type="protein sequence ID" value="VDM16414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WII4"/>
    <dbReference type="STRING" id="6205.A0A0R3WII4"/>
    <dbReference type="WBParaSite" id="TTAC_0000040901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000040901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000040901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000040901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41321" checksum="69540E31341C6FA0" modified="2016-01-20" version="1">MGDDEYFTLDELVSSETSESAVVYGAIEDEEEKCTFPKGYLKRQAVFACKTCYEITGKRAGVCYECSMHCHAAHEIIELYTKRHFRCDCGNSKFKGAGVCSLWEEKDDVNIENKYDHTFDGVFCTCLRPYPDPEIKENEEMYQCSICEDWFHLQHLNMPFDFQPNDDFEELVCPNCVKRFPFLWLFYYCQMQSRNAENANHFSDCSSPKKAKPDDIINQPEAPGSTEACRVPYVLSVCGVEKLDPPPADMVRLTVNGFPFPSPIFWCNDWRTDTLCDCNSCEKMLENMGLEFLLDPEDSVVHYMAVGRQRVAELHARRESICRFKEALTNFLTKPREQNVVTEEEVKEFCEDLKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIK4</accession>
    <name>A0A0R3WIK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-terminal-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS436</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000037">
        <property type="protein sequence ID" value="VDM16448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIK4"/>
    <dbReference type="STRING" id="6205.A0A0R3WIK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000043501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000043501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000043501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="120"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000043501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="635" mass="65586" checksum="0824AF1F6D26A89F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIV1</accession>
    <name>A0A0R3WIV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antolefinin Antolefinine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS556</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000055">
        <property type="protein sequence ID" value="VDM16642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIV1"/>
    <dbReference type="STRING" id="6205.A0A0R3WIV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000055501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000055501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000055501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031523">
        <property type="term" value="C:Myb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336">
        <property type="entry name" value="LIN37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31336:SF3">
        <property type="entry name" value="PROTEIN LIN-37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000055501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29415" checksum="1849332CFB5C757A" modified="2016-01-20" version="1">MSGGWNDRSWWPEPDGMDGKGVICFLEADVSLARENLDQILVAYKENPEKVKESLKYKDEVMNRKEVLEKEKYRSPLYKVGGSEVKRRKRGLVSDDDDTPKESFVIKVFERSVDFGQFPENAPLYPMARAWIRNLSQTDKSSWNDIPNTDDDREGTDQLPDCHYALPKPNDGLTDSQVRVPQPLPSSGQPFVINVENPPKEMSPEGLLEQHITRWREIRRKWKAACRENEERYRDSYIILREMYDKFCKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ44</accession>
    <name>A0A0R3WJ44_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS671</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000076">
        <property type="protein sequence ID" value="VDM16815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ44"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ44"/>
    <dbReference type="ESTHER" id="hydta-a0a0r3wj44">
        <property type="family name" value="Carb_B_Platyhelminthe"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000067001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000067001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000067001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="146"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000067001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="698" mass="78850" checksum="0F153AC84E3340DD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ59</accession>
    <name>A0A0R3WJ59_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS689</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000078">
        <property type="protein sequence ID" value="VDM16845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WJ59"/>
    <dbReference type="WBParaSite" id="TTAC_0000068801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000068801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000068801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260541at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="4">
        <location>
            <begin position="782"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="524"/>
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        </location>
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        </location>
    </feature>
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            <begin position="587"/>
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        </location>
    </feature>
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        <location>
            <begin position="600"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1280"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000068801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1849" mass="202362" checksum="844526C7F2648FC8" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL58</accession>
    <name>A0A0R3WL58_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000336">
        <property type="protein sequence ID" value="VDM18077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000149301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000149301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000149301"/>
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    <dbReference type="OrthoDB" id="10358617at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000149301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22403" checksum="BF74A802A70B4F16" modified="2016-01-20" version="1">MGTWKKFTLPWTALLRITPISSERRAFLYSRSRSEPQNWNGTAFCSSQLSEILLLRCCIKDLLETSTFFIFNQESNFAMAKARGSQFVDGGLKNLMLLIIPLTISVLAALAVLLKRRRRDRFDGMEFPPIQLRTTIASNLNDSMSGEGDDTIKATTQKTGSALRLLPKFEIRPEFGPTASGLVQLEVTHLAIAAPLSRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLM9</accession>
    <name>A0A0R3WLM9_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">Frem_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1654</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000431">
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    </dbReference>
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        <property type="gene ID" value="TTAC_0000166701"/>
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    <dbReference type="InterPro" id="IPR045658">
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    <dbReference type="Pfam" id="PF19309">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FRAS1-related extracellular matrix protein N-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000166701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21792" checksum="AEC6914D7F911062" modified="2016-01-20" version="1">MIRLLLPASLFFALITSAGVLSAPQQDSGSNLGTASDSFSLLAVNPLLPPARLKVYRGQWTPLLRQHLPITKRVLRGGRHVCRIEVEELAPIFSVVGHLEPKKFDCAFRDGEVRYYHEGNPLLTSDTVRVTIFFFRNNHSIIQTADIPVDVMDLPKTGNEIDQTFRRPRIHGPLELNVKGIKASSQAIGTSVIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLS2</accession>
    <name>A0A0R3WLS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1697</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000454">
        <property type="protein sequence ID" value="VDM18411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WLS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000171001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000171001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000171001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF304">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132872" evidence="3">
        <location>
            <begin position="20"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000171001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="865" mass="95290" checksum="463EAFE5BCCA9A33" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WME4</accession>
    <name>A0A0R3WME4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase_M16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1919</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000606">
        <property type="protein sequence ID" value="VDM18659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WME4"/>
    <dbReference type="STRING" id="6205.A0A0R3WME4"/>
    <dbReference type="WBParaSite" id="TTAC_0000193201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000193201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000193201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273757at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="225"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000193201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38269" checksum="354A7B0C0A3F2BBA" modified="2016-01-20" version="1">MGQMEVVKSSADFKSYRFTQLANGLRAMLISSLKPGETVDSDSDSESEVLEQCEEEEAACHDGNGSKSAMRKSAAALCVNVGYFTDPLEAQGLAHFLEHMVFMGSEKYPRENDFDDYVEHRGGSSNACTDGDYTMFFFDIQRSHFEEALDKFANFFIAPLLSQDCVDRELEAVHSEFELCKADDTCRLDHLLSSFAKEGSPYRTFGVGNRTSLRDKPSAAGTNVYELLRKFQLKYYNAPLMTLAVESKDTLDHLESMVNEIFGPISNRNCEAPDLSAYVNPFPSTVYKKMYKVCPVKETVSISFVWSLPPMHSHYRSAALKFVASIVGHEGKGSLVAYLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMG6</accession>
    <name>A0A0R3WMG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1941</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000624">
        <property type="protein sequence ID" value="VDM18681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000195401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000195401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000195401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000195401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="44" mass="5079" checksum="1A521683FBFDEE6C" modified="2016-01-20" version="1">MWTPFLLLPPSMRQFQCAEMCRVGLRDADPYEGVDDYQQGGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMP7</accession>
    <name>A0A0R3WMP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2022</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZFTRAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000690">
        <property type="protein sequence ID" value="VDM18762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMP7"/>
    <dbReference type="STRING" id="6205.A0A0R3WMP7"/>
    <dbReference type="WBParaSite" id="TTAC_0000203501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000203501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000203501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1737200at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039338">
        <property type="entry name" value="ZFTRAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059:SF4">
        <property type="entry name" value="ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000203501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="748" mass="85825" checksum="E5D3D6EFB9AAAC72" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMP9</accession>
    <name>A0A0R3WMP9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2024</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000691">
        <property type="protein sequence ID" value="VDM18764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMP9"/>
    <dbReference type="STRING" id="6205.A0A0R3WMP9"/>
    <dbReference type="WBParaSite" id="TTAC_0000203701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000203701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000203701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000203701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="765" mass="84744" checksum="18AC70B0557899D2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMR9</accession>
    <name>A0A0R3WMR9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000709">
        <property type="protein sequence ID" value="VDM18784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMR9"/>
    <dbReference type="STRING" id="6205.A0A0R3WMR9"/>
    <dbReference type="WBParaSite" id="TTAC_0000205701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000205701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000205701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287410at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000205701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32114" checksum="D528029F6C83F7AA" modified="2016-01-20" version="1">MSIVSSVAQKRTKSWKVEDVEKRRVFSLQLSQDEKTEVSNRPGLVTATSQPSVYLSAHAVKGTWPTVENIIRAHSITHAIEETTTRGFEFVKRRATTLDTDMSTPHRRGKAGSRRRLFSLFSKQGNGIRDKATLRAKQDCPSTNNLSNDSTAFNVVQNLVDSLGRQKSELKFTVSSLHDSIVQQGEKNCFQSSTRPINGLEDPRQERVTSLTRRWAQERYRSISFMDDDEEDDDDDASAVCLRRPAPERRRLNKLTTEEPHSVHRIYTCRSVAEKNYWLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMT4</accession>
    <name>A0A0R3WMT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Krueppel-like factor 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2059</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000722">
        <property type="protein sequence ID" value="VDM18820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WMT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000207201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000207201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000207201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000207201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39527" checksum="A24D1F51F2D55C7F" modified="2016-01-20" version="1">MSEGLAFSLTGQNHLSAPTIPLFPELTSFQNLNNTSNSDGLDTEGELHRRLKFKLHRTKPHEMSASNLKHKAAGAEPASRLAEILREQTLEGRIPLRRSSADLVDSSIILRLMAQQHQNSLHSHETSAFNVVSPLPASEDGVSPSSTPSSSYHTGPDAEEASCSMAKPFSCPFDLHVLSLNPTPQIHPVFTERRASDPCPASYASLQKQTVPQNARSAPTGRVKTHHCTFQGCDKAYFKSSHLKAHVRTHTGEKPYACDWEGCGRQFARSDELSRHKRAHTGERKFTCNFCPRRFSRSDHLNKHMKRHQLEVVTAATAINGSASSSGVADIEKRASIDVPSSLIPQETGPRFHLWSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN12</accession>
    <name>A0A0R3WN12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intersectin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2137</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000789">
        <property type="protein sequence ID" value="VDM19019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN12"/>
    <dbReference type="STRING" id="6205.A0A0R3WN12"/>
    <dbReference type="WBParaSite" id="TTAC_0000215001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000215001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000215001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150007">
        <property type="term" value="P:clathrin-dependent synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11839">
        <property type="entry name" value="SH3_Intersectin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000055">
        <property type="entry name" value="Intersectin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="EH" evidence="6">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="6">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="575"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="692"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="821"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000215001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="891" mass="100340" checksum="92C68AA41F88C852" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNG7</accession>
    <name>A0A0R3WNG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000932">
        <property type="protein sequence ID" value="VDM19531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000230501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000230501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000230501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000230501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9748" checksum="658EFD8EA23861DC" modified="2016-01-20" version="1">MSQSIIDTAIYYTLGCALDCTALRQWVHQRRVSLVEPVKGICSTLLCPTRPNRPGGWSVKVGFLTINCLAIDGGDGGVGRQNVTPGSGAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNV6</accession>
    <name>A0A0R3WNV6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-ATPase delta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2431</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001076">
        <property type="protein sequence ID" value="VDM20032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNV6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNV6"/>
    <dbReference type="WBParaSite" id="TTAC_0000244401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000244401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000244401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048937">
        <property type="entry name" value="ATPD_C_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21335">
        <property type="entry name" value="ATPD_C_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase delta subunit C-terminal" evidence="14">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM20032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000244401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17343" checksum="AD5E851C90AE1D32" modified="2016-01-20" version="1">MRFIRLLPRVYRSFIDRGISTSSNLSSELHLTFACPRSVFYNNAEVKQIDIPGSSGAFGILPEHVPTIATLRPGVVAVTEKDGAIKKYFVSSGMVTVNADSTVQVLAEECFPLEKIDPQLVRDNLAKAQSQFSSAPSEEKKVEAQITMEAYESMLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ58</accession>
    <name>A0A0R3WQ58_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LLGL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2883</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001631">
        <property type="protein sequence ID" value="VDM21425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ58"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ58"/>
    <dbReference type="WBParaSite" id="TTAC_0000289801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000289801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000289801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="1">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000289801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="33610" checksum="C6703AB8B0396097" modified="2016-01-20" version="1">MKRSFFSIPPEKRARLRLDAVVVLLERPSYPSQLLIGYSGGVCVLYDLQGERVLALLPCQYELESAAWCGGSGMPVRGAAVNPTATPPHLGTRVITAYGNGSLGVWQIPLFATGPGLATELGPQTLQMMESPSMPYGPFPCKLIGKVFWLLSHEGGITIFTGGMPRSIYGDRNTVSILRGSNLDQAAAANIAAALRADSEGDAAVGEDVCDTGMNADILLPNGLVPGAPVHVFDSDAPEHVCLDLPSPVVDACPLGTAGGPATGLLVLCEEELIAVDLLTPGWPLLELPYLNCLHASSLTAYGLFTQVNPAFLEGLESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQI1</accession>
    <name>A0A0R3WQI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3006</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001796">
        <property type="protein sequence ID" value="VDM21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000302101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000302101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000302101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132936" evidence="2">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000302101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36831" checksum="C58F87F6B54060C3" modified="2016-01-20" version="1">MQSGALVASCLSLLISLATLKADICPRGYWPADVQSASTEKAINQYNSDRKYSLPYGPIGNTPICRFCPQISCFIMRQMTEKKDSKKESMIRRRPRPHPTHSLTTTPRTSSLENLFPVFDNANATKLSEGHEDSNVMMTCVPYSELPHPEQVITYLDCVQIGQRDLYYLFIYVPVNKENEVAPVDCIDPNFLTWIPKREKLKGIELGFPMKKLPSYLFRYYRDIMEATEQVCIDSSALINYEIDPHDLQRFDGKVLTQTVYRHRGLKRNVLPPKQPPNTAETGHKSDEEVAECPNLTPTGVGRTFSDKDCRYAASAWLDPQVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQJ0</accession>
    <name>A0A0R3WQJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion_trans_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3015</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001804">
        <property type="protein sequence ID" value="VDM21748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQJ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WQJ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000303001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000303001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000303001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ion transport N-terminal" evidence="2">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000303001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39096" checksum="F3F9390D9E5F5494" modified="2016-01-20" version="1">MEIPCKPSSGESQCSSSHPVSVEKPLLHSIQSCTAEEDESELIDTTSALLSPIPKSDLLVNPPVAETNTTPQATRRIYKSRLHRSVTIGVGDEKDDEVGTTHSMTPSPHPLSSSQFRSRGMSQKTRWTSRIARLKSLQRSRTIDTRVNTVQWNPGSLLTSPDMDLKSNDARPTEYQPLHGSLNKLQKWLPDDGDSFVRLSKHPDCGPGSVASKEGRLDAGTQYYSPSSSMEMEQAPPTEMGAMNRKAKVSLNIPDAGRLATQSSDIASETAGASMPTEGQIPLNAAAMADGYVEELCDPSKQSTSSYLKEQFFAFFQPSDNKLAMKLFGSKSALNKEKRRQQQHGKWIIHPCSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR13</accession>
    <name>A0A0R3WR13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3188</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002043">
        <property type="protein sequence ID" value="VDM22126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR13"/>
    <dbReference type="STRING" id="6205.A0A0R3WR13"/>
    <dbReference type="WBParaSite" id="TTAC_0000320301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000320301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000320301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206130at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="149"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000320301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49148" checksum="B4062EE500C4E349" modified="2016-01-20" version="1">MTRNSHLETRACSLPPENSDVTSGYSPLKNSQNAKVEHLYQKNQNKLNAGGKVRIPNSVDLSLAEDTYPGCSDYDPCSPASIDVGNGNNKQSPSDCSSAFTDEDSGCQVFYFGNALRVASKCRMGRACSVSALDSPSVQPFNNKDEFLAAMTEDLADWMSRLYPDIAKDLDAENFFDRISDGVLLCHHATELHRLLEQEFPVNLQNGERRLEGVHIGGVRPVLPPNPPTFQSRGFNAANLAGSSFWARDNVANFIHWCRAMRLPDCILFETEDLVSRKNPRSVIVCLLELARLGGRVGMEVPEIIYLEKEIDNEIALSEQGFGSDHGTNTVNSPSYDWTGDTQDLENKTINVSTGTEVETNTSESSTEAPISKIPLPAKPMERRSNKAALLREKKAKEELEERKRQEALKAKQQEEEEMKNKKSQYKRPVIDMRTLDEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRV3</accession>
    <name>A0A0R3WRV3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3478</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds one Zn(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002502">
        <property type="protein sequence ID" value="VDM22712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRV3"/>
    <dbReference type="STRING" id="6205.A0A0R3WRV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000349301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000349301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000349301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018185at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000349301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26001" checksum="E5DB85CEB2CFAE16" modified="2016-01-20" version="1">MLDFPSSRFYLPVESEMCVDEMVPGAWDNAPDESMEYVTSTPPAKDSEPSESSHPRSIDFLPDHECTTSCAFQVSGIALADDSKGKSHLFILRRGENPWTEESFDENFEYNEIDAKYVPSPILHVDALSGQLFEAFGDELFILPHGISIAKDATGKPIALFVTDLARHQVMKFAWNEWSKPALILGRRNKAGNDEQSFCQPADVAVASTVKKLTKLCKYACIEMQKLSRICPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS13</accession>
    <name>A0A0R3WS13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone deacetylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3539</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002608">
        <property type="protein sequence ID" value="VDM22832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS13"/>
    <dbReference type="STRING" id="6205.A0A0R3WS13"/>
    <dbReference type="WBParaSite" id="TTAC_0000355301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000355301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000355301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285375at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132975" evidence="2">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000355301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16520" checksum="02F13F165EA41136" modified="2016-01-20" version="1">MHIIQHTSPIFALRTALLFDPAMLSHVCLCPHGNNPQVHPEHPLRIISVLERIASSRLQIPRGLLSSTSLTASPDQESYLALSEGLPLAFFCHWMRARMATRVCVYSSIVFVVWIVVTDCCLQLLSSMEFFINVSQITAKRAFLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS90</accession>
    <name>A0A0R3WS90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3615</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002740">
        <property type="protein sequence ID" value="VDM22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS90"/>
    <dbReference type="STRING" id="6205.A0A0R3WS90"/>
    <dbReference type="WBParaSite" id="TTAC_0000363001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000363001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000363001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000363001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34566" checksum="A1E150F17D788C8E" modified="2016-01-20" version="1">MSDRVFWRCSRRECKATAVTVGGRVEHVRILHTHKPPTPGEFFSSAAATATTTAMTEPISHLDMSVRSNPTGRVRRRSHHQQQLQQQTIKSVNEGTGKNSCSHSHVVATIPSIVERHQVEQQSSTDLKSGNDCKIIRENCFQSVNQKQRLPPLISPVSLSQEGSPKYPHFNEIDSRGLSALADAAVHQSKRDSQNSTPDPPFEAPAASPSLSQTTPTTHLLSPLIPSDSVTASATTVSGQFVLLGPRNLPTPLLVTSSSDVPFLPTPSYLSNYTRRFSVSEMPTSARNSLHKSLIQPELSQNLQTTVPSVSYSSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS91</accession>
    <name>A0A0R3WS91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002743">
        <property type="protein sequence ID" value="VDM22985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS91"/>
    <dbReference type="WBParaSite" id="TTAC_0000363101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000363101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000363101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244121at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000363101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18145" checksum="515144DCF02AE5D6" modified="2016-01-20" version="1">MDPITRDLPYSVSLSLSTLPYQVKRSGAMMVIKLGRMHRCPLSSDTLLWLSGVRNASAVALDINICGSLLTKSCQRDEAYKQMAALLATALVLFIISTIFAFISIFNKKCWVCISEFITAVAGGTLLLTALCIYYQGKQFWAPLVAGIAMTSGMQTSVFMLIDMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSC4</accession>
    <name>A0A0R3WSC4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3646</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002796">
        <property type="protein sequence ID" value="VDM23060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSC4"/>
    <dbReference type="STRING" id="6205.A0A0R3WSC4"/>
    <dbReference type="WBParaSite" id="TTAC_0000366401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000366401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000366401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM23060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000366401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27252" checksum="3A182B91ED5578DF" modified="2016-01-20" version="1">MEIFNLGMKLGMSLPYIPLMIIALIGNSLVCYVIHRYLQHSVTNIFLFNLSVTDILTTLAVIPMTAIADIWLNHWPFGATMCKLVPFIQCLTVTLTAFTHVLISCDRFLIVFRPLQRRRLLTPRRAKFLIILLWLTACVQATPLAVVGYLPEGANARCEESWDAHRSQAYTTTLMVMQYFIPLTLLICSYSVICWKLNSTQVIGAISATRSRMAVRSKRKVGKTLLFSQLSKDITVSSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSJ1</accession>
    <name>A0A0R3WSJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3716</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002917">
        <property type="protein sequence ID" value="VDM23212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSJ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000373101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000373101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000373101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="133"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000373101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46652" checksum="C0EB3890E48E08A0" modified="2016-01-20" version="1">TPVCVFYWFLLKYRTYSIYINFDALEQLSFRISRSSISCTRTWVGWFIHFKSPKTHLFLFYEKQVHFLSGSTLCAKADNSDPDVDILRTDDPTFNDRDQQPSLTQATSIPITENDTSVKVNGETDAVSEAIEKRKQPLMELAYSEESYVRRLRVVYELYIFEELASKLPPGGPTVPDDLVARWRILWGNWVQLLEWHTGFYEKLRTLLEDDPDRIPKLFIDSRARLRSIYSKYCENQIKAAHIAEQHKEFFDEWRVHVGDKEDVVSLLMQPVQRIMRYQLPISEIVKWTERAKLSSLVLWQKALDIMKEIPKDTQLILEVDLFLVRFSFLPSDRQWLRAYCSYAPKITGLSGKMNSNMGDFMQLGARGRRLEGDCLTGVGWVKRAHLWRCKRLVFSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT67</accession>
    <name>A0A0R3WT67_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3941</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003330">
        <property type="protein sequence ID" value="VDM23814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT67"/>
    <dbReference type="WBParaSite" id="TTAC_0000395701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000395701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000395701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000395701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="553" mass="60854" checksum="5851D909A604943E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTL4</accession>
    <name>A0A0R3WTL4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPPC8 C-terminal Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4088</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003638">
        <property type="protein sequence ID" value="VDM24149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTL4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000410401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000410401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000410401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10558049at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000410401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15334" checksum="4F6CE45E16815B5F" modified="2016-01-20" version="1">MATIPVGVEIYNASSCPVTARISTAEDNTSRSPTVPQQPSPPRVLWTGVCVQQIPLAAGQIHRLTLIARVACPGVYEVNSLCLKASISPSATSPLPPPSRPHSSSISDKRGAVLPTGPVVAITSPPAPFVRQLCDFSSLVVVVAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUJ5</accession>
    <name>A0A0R3WUJ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectonucleoside triphosphate diphosphohydrolase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4419</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004371">
        <property type="protein sequence ID" value="VDM24896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUJ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WUJ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000443501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000443501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000443501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000443501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18577" checksum="AEAAFE1A0CBEEF21" modified="2016-01-20" version="1">MCRSLPFVLTGLLVLYLAFSLNRFFFIVTQDRVLYGVIFDAGSTGSRARVYKILKNASVILLIMKSERCRYQLVGEEVFTVEPGLSEFARFPHASVAYLRPLLDQVRTCIPEHKRPLTPLVLRATAGLRLLPEQVANALLESVSWPLDTSPLIPILNVMLIFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVR2</accession>
    <name>A0A0R3WVR2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4837</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005455">
        <property type="protein sequence ID" value="VDM25746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVR2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVR2"/>
    <dbReference type="WBParaSite" id="TTAC_0000485201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000485201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000485201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000485201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36052" checksum="C73977636B53546A" modified="2016-01-20" version="1">MARFVGRREEAVFLSPFGFSDLPKGGSLLSKRVIDIVNSATERQLGRLDIYTFSEFLSKVTSTTLITALILVDKFRQLDPKPLLFYEITATELLIVATLAASKFLHDTDTEEGLSNGAWASTFDIDLKALNAMEIRFFSALHWNLFVSKSDFNDFLMNRFAAPVPSGKVVRNRSKRQHPDPIVRGISSTSFRQKRGKSLPRWSLAKAMAMCAAAFLAFSHPGMSNISDDSYMELLLASSSLTSPTSSPEIPDLSSLLADRLMVLSVSGFNYTMPGFHSCRNAPNDSRFSHAPEERLHHNSTNAIHTHLHVQKPNFVPTLLVVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW00</accession>
    <name>A0A0R3WW00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4925</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005681">
        <property type="protein sequence ID" value="VDM25890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW00"/>
    <dbReference type="STRING" id="6205.A0A0R3WW00"/>
    <dbReference type="WBParaSite" id="TTAC_0000494001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000494001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000494001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279339at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000494001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16573" checksum="9F73D46AF0D67649" modified="2016-01-20" version="1">MVSKLRLAGTFVCALIICLIIWYTLAPYELFRTPSQPDPPHPDSVLCRWPPTTPNDIRTTSNTYNITICVHKDSQSLAIKSDPTYSMKSLCRDVTSNRSITFKEFGECDPSICKSPIYPDVYRTYPQDVPIKEILRSIKSGVPVSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWE4</accession>
    <name>A0A0R3WWE4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5069</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006131">
        <property type="protein sequence ID" value="VDM26191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWE4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWE4"/>
    <dbReference type="WBParaSite" id="TTAC_0000508401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000508401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000508401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000508401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7281" checksum="E34DAEE32EFF749D" modified="2016-01-20" version="1">MGRAVHTNLYARFCVDCLKVAVIKNSWLACRLGGDLFSVIFRYEEYSSESDTAAAEADTAKQAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXB7</accession>
    <name>A0A0R3WXB7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidored_molyb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007319">
        <property type="protein sequence ID" value="VDM26875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXB7"/>
    <dbReference type="STRING" id="6205.A0A0R3WXB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000540701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000540701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000540701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278762at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000540701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17622" checksum="DF378978B9979426" modified="2016-01-20" version="1">MFAGFALQFIHQIHGSLIVHAHEYAVMWPFSSAGRGEVEDTDWRFFLTGGVALENPHPNPAPTWLGEKNWSEIVRASELPALEGLMKSVRSDPNRWKMVYDSPVPHEATFPAPFQKTSDMNRLILVRCLRSDKVIPAVQVRWKLRSPLARRTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXE2</accession>
    <name>A0A0R3WXE2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calpain_III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5416</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007418">
        <property type="protein sequence ID" value="VDM26933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXE2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXE2"/>
    <dbReference type="WBParaSite" id="TTAC_0000543201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000543201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000543201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C2 calpain" evidence="8">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM26933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000543201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23742" checksum="948959DA39C28F52" modified="2016-01-20" version="1">MAFKDFKHYFSRLEMCHLSPDFDQMENTAKGAPPKRKWEMTRHEGEWLRNSTAGGCLNNRNTFYMNPQIRVSVVDADEADNDPTGTIVVGLMQKGMREKRQSPFSIGYAIYPFPPGAPANALLTREFFLRTPMSARSIFANTREVCGRHKLMPGDYVIVPSTFMPNEEAKFLLRIFSERPYTAGYVDCKRLTAFLHFLKIKSDINNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG2</accession>
    <name>A0A0R3WXG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF4604 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5437</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007516">
        <property type="protein sequence ID" value="VDM26996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG2"/>
    <dbReference type="STRING" id="6205.A0A0R3WXG2"/>
    <dbReference type="WBParaSite" id="TTAC_0000545201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM26996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17781" checksum="9E892D50C7FDD9CC" modified="2016-01-20" version="1">MSFRAPKRRHVKSTRFIKDSDSEDEGEPGPTDLKNNPSNLSVEEAVECIRTWQNFRKRHAGVSAESLFVGRKIEPEVLIEDDPFKMKTGGLVEMRGAFLKPTKEEFEDEVRLSRTFTAETNKRDEDADMLKYIETELAKRKGITKTEAEAPKYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXQ9</accession>
    <name>A0A0R3WXQ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SLC3A2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5533</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007870">
        <property type="protein sequence ID" value="VDM27173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXQ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXQ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000554901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000554901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000554901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000554901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17469" checksum="7F7883E4E3B0FF23" modified="2016-01-20" version="1">MEAESSDSGGNSNRTRSRSGSIKGAQESNTKTDEGYKATVIVEGEEANGKQQENLETSATGRVKLAIFWMYIRSMSLGLFLGGVLFLFLTQIAWLGSNIWLADWSNDASKFVNATNISPNQTSLEPVKSVGLRLGVYASIGTCQGKLSLKPFPIVLNCLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY03</accession>
    <name>A0A0R3WY03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-mann_mid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5626</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008286">
        <property type="protein sequence ID" value="VDM27343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY03"/>
    <dbReference type="STRING" id="6205.A0A0R3WY03"/>
    <dbReference type="WBParaSite" id="TTAC_0000564301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000564301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000564301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="2">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000564301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17195" checksum="1E095ED5EAE46A0D" modified="2016-01-20" version="1">MHRDNVVVNYLRPYLPYRNADILFSIASHWSPGADKVTTLLFGLYDQLTVARRDLALFQHHDAITGTSKSHVMADYRDKLNEAIRCAQNVSATSAAFLLGYEFPEVCSALEHEVSTRTSPVLISANPSWGGSSVPEFFPITLESLEAVKTLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY82</accession>
    <name>A0A0R3WY82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5710</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008660">
        <property type="protein sequence ID" value="VDM27498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY82"/>
    <dbReference type="STRING" id="6205.A0A0R3WY82"/>
    <dbReference type="WBParaSite" id="TTAC_0000572201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000572201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000572201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="1">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000572201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16299" checksum="76FF9A13B071A09A" modified="2016-01-20" version="1">MEGLFTSSWQVRFQYIGCLASVLSGLSLYHKDFAVAVVDNVIEDVRVGMEKNDQTMNQRRLSMVKYLGLLYNYKLVESPVIFTTLYSLITFGVSLDYLSPSLIDPPTSLARIPLVCTLLETCGSYFDRGSRRKKLNIFVVYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYE3</accession>
    <name>A0A0R3WYE3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5769</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008974">
        <property type="protein sequence ID" value="VDM27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYE3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYE3"/>
    <dbReference type="WBParaSite" id="TTAC_0000578301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000578301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000578301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000578301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9955" checksum="E8FB07AE3EB7A4A4" modified="2016-01-20" version="1">MNTTVPASTTYNSSQQAVHTSAACEFTTFEFVGYFYILTIVCFIGCIFNFINIIVFAQKCFRATVYTYMLAISLTDAIALLVNLPTGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZD0</accession>
    <name>A0A0R3WZD0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6127</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZD0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZD0"/>
    <dbReference type="WBParaSite" id="TTAC_0000614201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000614201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000614201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000614201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="747" mass="80950" checksum="49C90474872ADE08" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZF0</accession>
    <name>A0A0R3WZF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6153</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZF0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZF0"/>
    <dbReference type="WBParaSite" id="TTAC_0000616801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000616801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000616801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035275at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000616801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="870" mass="95301" checksum="FC1247873C019CA1" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZK3</accession>
    <name>A0A0R3WZK3_HYDTA</name>
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        <submittedName>
            <fullName evidence="3">39S ribosomal protein L37, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZK3"/>
    <dbReference type="STRING" id="6205.A0A0R3WZK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000623101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000623101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000623101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000623101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56314" checksum="E7057465342E6A63" modified="2016-01-20" version="1">MRLSLLLCRRIRHDFLPVYIKKQWKEQGSIMTARRLRVPQQALADPRIAEVAAQAEDTFVSTRYRDALAREIEIGATPEERAAWELQLTQRLAQFGDITGNVSASSPSLIFEPSRLFCRDIAQVAMLTNTVVHEGTPSALQSIYEKLVLSPAVNTQSLLSAVERSVLHAHVWHTDEDKLPKRYNPDLLIWKFKTEFGIHPTNVARYLLFNLFRVCEIQALEMHLTPSSDPHTGLPSRWLLRDRFVETSFLWGEEQPRRVQFSQRNDLVLLSPTPTPLCEHPAAALTATQAQIFEDLKTRMHLISPLIDLTSTTQYREDSSDGIHTTNYPYPHLITVNIALPNTWSDFTAPEKDRITVAQRQTIGLMHCYASCLATAKRLYGNECAKAPLPEPIAVQAVCTDGVFFDFITFQLNTLATPDWSKNPAPQAPMNLAWVDGNHEIVRKHYPKRSMLRNTKYTDLDMKVFYRLFAYYLYGMLATEDEKTESLVVNSGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZY9</accession>
    <name>A0A0R3WZY9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6384</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZY9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000639901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000639901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000639901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000639901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11898" checksum="7E63D50F7728B394" modified="2016-01-20" version="1">MSGGTSTTAVRHVDGEGLKRVLGENRLVVINFCAPWCGPCHLLAPKVEQLAKQHQDVVFVKVNIDECEDVSAEYNVSALPTLIAVRNGHIVGRVVGASEADLQQMVNASCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X043</accession>
    <name>A0A0R3X043_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6452</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X043"/>
    <dbReference type="STRING" id="6205.A0A0R3X043"/>
    <dbReference type="WBParaSite" id="TTAC_0000646701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000646701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000646701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
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    </dbReference>
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    <feature type="domain" description="Nrap protein" evidence="3">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="4">
        <location>
            <begin position="148"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="5">
        <location>
            <begin position="400"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000646701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="789" mass="88041" checksum="D1786607CB033C45" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X083</accession>
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        <submittedName>
            <fullName evidence="19">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS6496</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="VDM30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000651101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000651101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:deoxyribonuclease I activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="paz domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_3_1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
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            <end position="925"/>
        </location>
    </feature>
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        <location>
            <begin position="1139"/>
            <end position="1280"/>
        </location>
    </feature>
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        <location>
            <begin position="1474"/>
            <end position="1596"/>
        </location>
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    <feature type="domain" description="RNase III" evidence="14">
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            <end position="1838"/>
        </location>
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            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1340"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000651101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1934" mass="215031" checksum="F0B59ECF976E7ECD" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0C2</accession>
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        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020308">
        <property type="protein sequence ID" value="VDM30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3X0C2"/>
    <dbReference type="WBParaSite" id="TTAC_0000656501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000656501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000656501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="WDR53"/>
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    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000656501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="38772" checksum="BC7B7898D1A006F0" modified="2016-01-20" version="1">MVLLTSLSGPATVSCLSLSSKLFACGFENGSIHLTSPNNYASPTILSPSSRPCTAIALAGDDSDILYSSHNGNIAFWDIRKHQTPLNVCKVSNDDINCIDVNAGDGCLATADDVGMVSLISSLTGEVMCVLNNHDNICSAAKFRPTRQNQLISCGMDCRLVVCDWKSGDRERIVIEMTKLVDPCNYFRLLRSCVNEGKTYHRRRGRNGEDVFSVRIASSFTPEEVEQMVKTRAYSQSLLLNPPMIHSLGCDDSGKYVAVGLGNGAVEIFKDDKNFRHVESLLGHRRSVSALLPVGSSHLLSGGDDCCLFLWEMSRNGTGQRFVHSEKIGALAGRELGRVFVADNTSDVKVMDLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0H4</accession>
    <name>A0A0R3X0H4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6617</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0H4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0H4"/>
    <dbReference type="WBParaSite" id="TTAC_0000663201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000663201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000663201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242242at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000663201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63583" checksum="438BDA0DE6758E8A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0R9</accession>
    <name>A0A0R3X0R9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6736</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020319">
        <property type="protein sequence ID" value="VDM30990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X0R9"/>
    <dbReference type="WBParaSite" id="TTAC_0000675101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000675101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000675101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="83"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000675101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37062" checksum="3EA858FE63F77263" modified="2016-01-20" version="1">MNRKETTRHHAREINNKERAKKAKEKRQRRREQKKSGKIAGIPHTLETLRNPDETILPRDDVDLLHEEENDELSRIYSGAVEPKLLLTHSDRVTPPTIGFCKELSRVIPNTTFVPRWHLPLKKLIPKAIEHGYTALLVVNDDMKKLNTLVVSHLPDGPTATFHVTNVTPRRKLRGLKNRGIEEGVIPHLILNRFMTTLGRRVERILGALFPSASRGSPPPHCRTVVFHNQRDFIFFRHYRYIHRKNGDATTDRKNYVIDNEGDEADAGSSVRPSDRVVVNEVGPRFTLKLKSIQVGTFDSQFGDYEWVKKGAVIGKSRRTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0U0</accession>
    <name>A0A0R3X0U0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore membrane glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6761</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X0U0"/>
    <dbReference type="WBParaSite" id="TTAC_0000677601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000677601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000677601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2091"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="4">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 fourth Ig-like" evidence="6">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="3">
        <location>
            <begin position="649"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2128"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2212"/>
            <end position="2221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000677601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2221" mass="238925" checksum="118E4D6CB0080C4C" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X161</accession>
    <name>A0A0R3X161_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6897</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X161"/>
    <dbReference type="STRING" id="6205.A0A0R3X161"/>
    <dbReference type="WBParaSite" id="TTAC_0000691201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000691201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="9">
        <location>
            <begin position="177"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42276" checksum="DBDC74C048A7C6B5" modified="2016-01-20" version="1">MLDQSIDLVKHDLFNLPFTGALGWKQGDEESKWAQKAIETLVKKLKKRKGVVDRLQYALSHPGEPSECVSIPRSLDGRIQVSHRKGFPHVIYCRVWRWPDLQSHHELKSLECCQFPFDSKQKEICINPYHYKRVDYPVLPPVLVPRHSEYPTVKEGQSTSFEFLDSQSIPYQEPRYWCTVVYYEMNTRVGEAYFASSPSVLVDGFTNPSKTSDRFSLGILSNINRTPVVENTRKQIGKGIHLYTVAGDTFIECLSDSSVFVQSRLCNESHGFHPTTVVKIPPGCSLKVFSNSEFARLLHQTVSLGVEAVYDIVKVCTLRLSFVKGWGAEYHRQDVTSTPCWVEIHLRGPLFWLDRVLRQMGPSPNPVSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X174</accession>
    <name>A0A0R3X174_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6916</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020332">
        <property type="protein sequence ID" value="VDM31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X174"/>
    <dbReference type="STRING" id="6205.A0A0R3X174"/>
    <dbReference type="WBParaSite" id="TTAC_0000693101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000693101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000693101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133159" evidence="11">
        <location>
            <begin position="28"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="150"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="258"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="394"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="520"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="648"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="764"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000693101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120683" checksum="FBE46C1811FC46B9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1S8</accession>
    <name>A0A0R3X1S8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7173</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020350">
        <property type="protein sequence ID" value="VDM31510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1S8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1S8"/>
    <dbReference type="WBParaSite" id="TTAC_0000718801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000718801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000718801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000718801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46342" checksum="C360F0570CE3AB41" modified="2016-01-20" version="1">MNTPSVVTGLKAVVYFLLKYFNAFIFLEKPSIDALRADEEFRPILDAHIRYERPPSSGDRKGSMTAVERFDLPPEIADAGKNPDQFWQTDRQMVNFESAIVVFDSQMVNEPNLTDMVICMGGDGTLLHVASLFQDTVPPIISFYMGSLGFLTPFNFADFPHVLKQIYTGMSNVKSIFELLGKFLLLKLTCLLHLQLRSEGGPCILRSRLCCQMIRGENSETCPHTSIELDSVKNQTGADFFHILNEATFTRGNCPYLTVLVLSVDGKEVTRFCGDGLIISTPTGSTAYSMSAGASILNPGVPAILVTPINAHSLSCRPLVLPFSTRLEVFIAPDARCESVHLSNDGRLRHHHIVHKADRVVFTASHFPVPCFGSENQVADWFKDLAHCLHWNARHRQNEFNEANFLPERFHEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X268</accession>
    <name>A0A0R3X268_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7346</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020364">
        <property type="protein sequence ID" value="VDM31712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X268"/>
    <dbReference type="WBParaSite" id="TTAC_0000736101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000736101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000736101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033661at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053291">
        <property type="entry name" value="Ommatidial_diff-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF16">
        <property type="entry name" value="HTRL DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000736101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="941" mass="104082" checksum="00976A4D8BDF467D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2J3</accession>
    <name>A0A0R3X2J3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020377">
        <property type="protein sequence ID" value="VDM31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2J3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2J3"/>
    <dbReference type="WBParaSite" id="TTAC_0000751001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000751001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000751001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000751001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37267" checksum="0B07319BC77477E9" modified="2016-01-20" version="1">MELGGVARTPIRQRELHFRPSDMVKSEVSMLLTSLKCGYRSNSRSYQDNAKRALLDNLISLRRTLNATPDLDSLNPLTYLTPFLDVIRSDATTGLITGLALTSVEKFLAYGLLEVRSDSLYASQNVIGIAAETIAEAVIQARFIRSRLSSDEVVLMKIVHLLRTLLLIPSGCLLSNVMVGEILQNCLRICLESQLSELLRRTAEQFLASIVQLFFSRLPALLLTDETSHQLGVDEEETFRISDEGSSRKGSRRPTIHTETSLMGENPEINQEVKTEESLQLNLFPCQRINYPFVESLAKDAIYNSPEVLSRVYSLTVVDAVLQNGGTVWGSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N3</accession>
    <name>A0A0R3X2N3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7545</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020382">
        <property type="protein sequence ID" value="VDM31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N3"/>
    <dbReference type="WBParaSite" id="TTAC_0000756001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000756001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000756001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133168" description="Nuclear migration protein nudC" evidence="8">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="9">
        <location>
            <begin position="249"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000756001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50812" checksum="43992B94BF631D6F" modified="2016-01-20" version="1">MSFASKVTFVASCVAAIGVIAYVHIEQALEREVANKCHCTRRNRGNESPYKRPNRVTVMFRTISDCCGITGNLVDMSDHLDGLFLNIAQNCPDGIRGMLDAFFGFLSRRTDFYYGAAINDAKQLVLEQFEKHKTAALDRHKREKEELRVKEEREKRRRAERAEEALRKSADNDVHSGVVIEEVKDDEKVGEMVKVEEEGQESAKASPKGDDGIEAKAPVKPVKVGPLAEGEEEDEEDKGKLKPNDGNGADLDRYRWTQTLQDLEVRIPIRMGKRIKGRDVVVEFKRRHLKVGLRGQEPILQGELYNEIKVYILCVNVRLKMLFVAFALASLELSIKQKRGNAEESSWTLDDGLEIVLSLEKVDKMFWWSCVVKGEPEINTRRVQPENSKLGDLDGETRGMVEKMMYDQRQKQLGKPTSEEQKKQELLKKFMDAHPEMDFSKCRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N5</accession>
    <name>A0A0R3X2N5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7547</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020382">
        <property type="protein sequence ID" value="VDM31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N5"/>
    <dbReference type="WBParaSite" id="TTAC_0000756201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000756201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000756201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428774at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000756201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24745" checksum="875ED4915A4D7218" modified="2016-01-20" version="1">MTQEMPKEALVKTLQKLLEPVSGKPVYLTANDLLAVWDFFDIDHDGTLLAEEYELFIRILGEILKTVFPNYGRTSLPDLITAAINPGLPYQIGIDEISHLLNEEERFLLVFRKLSNIQSSFDFMKTFLEKLLSKSTVPVTHEKVEEFASLIDHSGVIENEEFEGLVKDLLDIAKKSYDTKDLDEFKTNLLRQWDENSDGKISKSELKLLLLHSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2W9</accession>
    <name>A0A0R3X2W9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="7 8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7647</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020391">
        <property type="protein sequence ID" value="VDM32064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2W9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2W9"/>
    <dbReference type="WBParaSite" id="TTAC_0000766201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000766201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000766201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000766201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="670" mass="76353" checksum="15C23C2D1D11B33E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3C2</accession>
    <name>A0A0R3X3C2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7825</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020409">
        <property type="protein sequence ID" value="VDM32287.1"/>
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        <property type="gene ID" value="TTAC_0000784001"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="CAP, ISOFORM AC"/>
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        <source>
            <dbReference type="EMBL" id="VDM32323.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000786901-mRNA-1"/>
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    <sequence length="156" mass="17567" checksum="FCBA1ED9418E0849" modified="2016-01-20" version="1">MNVFHVLWRQLRAVLILRCRCACAHAEVDRGQNVLSGFFSCVSISRLVVVLPQSRLVAGTENLSSSTTRCLSSSACFTSFYGLVCISCPCCRALYQFEAENDTELEFSEGEVIQLIRQVDENWYEGRLNNKEGFFPVNYVEVIEPLPSSATDFYAN</sequence>
</entry>
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    <accession>A0A0R3X3R6</accession>
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        <submittedName>
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        <name evidence="10" type="ORF">TTAC_LOCUS7988</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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    <reference evidence="10 11" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
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        <property type="protein sequence ID" value="VDM32470.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="SID1_TM_fam"/>
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        <property type="entry name" value="CHOLESTEROL UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="398"/>
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        </location>
    </feature>
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            <begin position="455"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="863"/>
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        </location>
    </feature>
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        <location>
            <begin position="218"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="230"/>
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        </location>
    </feature>
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            <begin position="350"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="574"/>
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        </location>
    </feature>
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        <location>
            <begin position="590"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000800301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="897" mass="100039" checksum="AD2AB53792DC2BB8" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3V8</accession>
    <name>A0A0R3X3V8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OCIA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8041</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020435">
        <property type="protein sequence ID" value="VDM32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3V8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3V8"/>
    <dbReference type="WBParaSite" id="TTAC_0000805601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000805601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000805601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003372at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCIA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000805601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23403" checksum="E06441898ACDE345" modified="2016-01-20" version="1">MSGLETGPPELTIEDLATFRRCRKESFWRRCVPMIMGASLVVSLGQSRGFFLNRPRLLMPSYFLAGLIGYVGGKMSYIGHCKRMFLELHDSRVKDFLLGHQSCLPLPRRPDFSVEHDWPRSEGDPVVVRTPTTYAERREYYRQQEQRQLAQGSPAPPPPPTPGNQEGSQGSLQQQTSSKSPSSEYFDTERPLSSYLSDDEYRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3X4</accession>
    <name>A0A0R3X3X4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8061</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020439">
        <property type="protein sequence ID" value="VDM32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3X4"/>
    <dbReference type="STRING" id="6205.A0A0R3X3X4"/>
    <dbReference type="WBParaSite" id="TTAC_0000807601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000807601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000807601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000343">
        <property type="entry name" value="Ets at 65A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000807601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65492" checksum="4423F95D69372BDC" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Z9</accession>
    <name>A0A0R3X3Z9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8088</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020445">
        <property type="protein sequence ID" value="VDM32585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Z9"/>
    <dbReference type="STRING" id="6205.A0A0R3X3Z9"/>
    <dbReference type="WBParaSite" id="TTAC_0000810301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000810301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000810301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133175" evidence="4">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000810301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="37812" checksum="AE8033757EB4A8D0" modified="2016-01-20" version="1">MRILFIASKFLSGCILLPPSLCVSHLKVTLTSECRGEVELWLTSPMGTKSKLLSKRPFDLDVAGFHAWPFMSVHFWGEKANGTWTLTVHSGNAVDLGLVPSAMGPKYEYSSAPVISGMLVSLIGWSLTFYGVSTKPPHHPSRQQSTLPSRGPRERQIHPLASMLGEHEPVVPPPLPIPFGSKTSISFSPEAYAVELGDKPPPPPPPPFPLPFGSDFLDIWSDHAVDAVSEGEGTVIGGSGGYQSNGKWYNNLHNVYQAPPSKPKTANSLDPSQIFHSAYLGGYGLERLNSPRKSNAGGGGGGGVSAGWQRIEPNRQSAVKSVKSSAGWWLREEGDGSTVVTLALKSVSKGHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X440</accession>
    <name>A0A0R3X440_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S5A_REDUCTASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8141</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020454">
        <property type="protein sequence ID" value="VDM32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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        <name evidence="2" type="ORF">TTAC_LOCUS8453</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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    <accession>A0A0R3X5B8</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM33245.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000864801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="74637" checksum="1EB1905F7B5BF081" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5M6</accession>
    <name>A0A0R3X5M6_HYDTA</name>
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        <submittedName>
            <fullName evidence="3">ATP synthase subunit s, mitochondrial</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TTAC_LOCUS8766</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020581">
        <property type="protein sequence ID" value="VDM33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0000878101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000878101"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="VDM33409.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000878101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58240" checksum="C7D98D596721C8F3" modified="2016-01-20" version="1">MRRSLDLVLFSTYNHSHILRRCFANQKTSSTDPFDGYTRSCHIKQQFVELQTTAADGSIKVRKVPTGLIDNSNEWIGDQMVRAHLKITHDFDLTMQGFAERARKRLLAKHKQRQVYVPVAYYLRSDWKIDVYVSELNGELYTLQSLLLNSITDEMIKRRGSLDLAVAHMVCDLGGRVQFVGEPLGCWHQSYNRGPPNLPSTYSDDLKLEIIDFSGTAVMYEGLEMLPRLTCLKMLRLRRCLYLNDHCLSLVGQITQSPLEYLDISECPRISANGVTALTELKSLRRLLIQGNPTMKDRELVCLLLEDYLPKVYIEGVDYLGNLPEDARQRVLALDVPEKPPLLAEHIENIEREGEADVLRVEVAVTNMDRFAFAPMTTTDFVTKILNVKEEFLRIAETVNDDVRSASQFFDSVFVESVLPPNFNFNSKSELSENIGNYSLLKDRNNHCRTPSETANSNPITENEADLVRLISDMSAEELIFLKNQLLLELNWLDQAINSRKQFLFSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6I5</accession>
    <name>A0A0R3X6I5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pulmonary surfactant-associated protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9106</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020681">
        <property type="protein sequence ID" value="VDM33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6I5"/>
    <dbReference type="WBParaSite" id="TTAC_0000912101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000912101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000912101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279056at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000912101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24015" checksum="E2675AFFE26C6418" modified="2016-01-20" version="1">MPVSSDVSNDSNCGGGGGGSATPHSSKSPSATTSLPVSPSTPTPQQRRTHRRRTTIAVVTVCLLLAAVIILQIVIVGLILNSRLVQNATGVSLLIHNQTGETPSELQVRGQLLQLADLLSWDAKCNRVLHDLVVSCYGAPDYLANKAKEGSRSGGGRVGGRFQFNRNFPHNLETPSRHALKPRKLRQLMSPGSEVDQRNQSHLEREGISGVASVDNLQTNLEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X796</accession>
    <name>A0A0R3X796_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9404</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020801">
        <property type="protein sequence ID" value="VDM34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X796"/>
    <dbReference type="WBParaSite" id="TTAC_0000941901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000941901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000941901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000074">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="189"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="670"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000941901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="701" mass="79463" checksum="9C029F4D0E779D21" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7L8</accession>
    <name>A0A0R3X7L8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9528</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020871">
        <property type="protein sequence ID" value="VDM34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7L8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7L8"/>
    <dbReference type="WBParaSite" id="TTAC_0000954301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000954301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000954301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF17">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000954301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115544" checksum="109F25BD456AB014" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7W9</accession>
    <name>A0A0R3X7W9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9629</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020941">
        <property type="protein sequence ID" value="VDM34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7W9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7W9"/>
    <dbReference type="WBParaSite" id="TTAC_0000964401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000964401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000964401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="64"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="840"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000964401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="896" mass="101878" checksum="9355F82C00C5370F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8C1</accession>
    <name>A0A0R3X8C1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9781</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021045">
        <property type="protein sequence ID" value="VDM34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8C1"/>
    <dbReference type="STRING" id="6205.A0A0R3X8C1"/>
    <dbReference type="WBParaSite" id="TTAC_0000979601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000979601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000979601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000979601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12618" checksum="B295A1118716B4FB" modified="2016-01-20" version="1">MDTKSELACTYASLILADDDIEVTADKLNTILKAANCKFVESYITSLFANALSGRNIRDIISASSNVSVAAAPSAAAASGAPKVSGGAPAVEAAPEPKKEEEKKKEESEESDEDMGFDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8G1</accession>
    <name>A0A0R3X8G1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nas2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9821</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021080">
        <property type="protein sequence ID" value="VDM34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8G1"/>
    <dbReference type="STRING" id="6205.A0A0R3X8G1"/>
    <dbReference type="WBParaSite" id="TTAC_0000983601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000983601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000983601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000983601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19216" checksum="6E8ABFF5C3C3D104" modified="2016-01-20" version="1">MADNSTDMVLFQELEKKRQSIVNEINTYTAVLEGNRNVGMHGPLLDSEGFPRSDIDVVAVRTALSSFLFVGLNTDHNEVMKQLETVSARLLSKTRGGAEEMDTDSPIARPSTEPPSRSVPFLLVDQVAPGSPADQAVGRPAFCAIGFCETTPAKHGLDLKQLFLLLFNIYHCPKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8K8</accession>
    <name>A0A0R3X8K8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021119">
        <property type="protein sequence ID" value="VDM34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8K8"/>
    <dbReference type="WBParaSite" id="TTAC_0000988301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000988301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000988301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268013at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000988301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32631" checksum="E7C4AC867FD4B793" modified="2016-01-20" version="1">MSAGDIGDWEDQVSPDDISLAASNLRRKSIRRSMMVIPASSDSPIGYSSPKIVVRRKSLGTALKNDCTSSLQPVSPLSGQGPEHMKVYPGHLPTSPRPPDDTSPDEASPSHSHAGAQFSDPHVESLSRKYVKNSDCRKSPTSYDTKSLPNSVDALFENYERELSEWPRLLNRLEHGASFPLQKPCMKLEEMIGNSMLNPFVEFISSNKSSSAVNELQRRTKWAYRSVMTGLVRTKLAYKKLRYSVAALERRNAELKNAKLKDLLPHLALNPSPMSARDLLAFIPCLREGGELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8V2</accession>
    <name>A0A0R3X8V2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9962</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021194">
        <property type="protein sequence ID" value="VDM34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8V2"/>
    <dbReference type="WBParaSite" id="TTAC_0000997701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000997701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000997701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000997701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="257" mass="27804" checksum="B2668B9A88D5352B" modified="2016-01-20" version="1">MNAGRIGVADGCPVAAAAAAAATCLRPSCQFFVSWKNVWKEPCRGSTLRYRLMIDRERVLQFILRLSVRFTAFINKALFLLLLLLLLLLSFLPSAPIFFQSSSCWHGGGGGGGGGGDDGHLSTGLPTRESDRAKEEEEEEEEKNIITMEKNAARWMDFCDVVGQGLWIHKLKAWRIGGTSGINAWVLMVKVSVGLQPWYSSAAAVSSSSQRRVVETTMGLLLVWSCVALVLVRCDLALSIWTAPVPLGGVSSAVVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Z4</accession>
    <name>A0A0R3X8Z4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10004</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021233">
        <property type="protein sequence ID" value="VDM34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Z4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Z4"/>
    <dbReference type="WBParaSite" id="TTAC_0001001901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001001901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001001901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001001901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19641" checksum="2B210255C35BFECF" modified="2016-01-20" version="1">MMPSLSHLTVSFRESAARALPLFTSYCRIFTVPCRSGESLTTKRNRLLYESRKRGNLENGIILSSFADRHLGEMTEEQLKVYDHLINTPECDWDIFYWIVGENSLYSSPSWRRLFRPLWLVFTHCLLGEKEAPDEYKSDVLEMLQRHARNYGRDLRNQQSEILPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9F9</accession>
    <name>A0A0R3X9F9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10169</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021385">
        <property type="protein sequence ID" value="VDM35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9F9"/>
    <dbReference type="STRING" id="6205.A0A0R3X9F9"/>
    <dbReference type="WBParaSite" id="TTAC_0001018401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001018401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001018401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048495">
        <property type="term" value="F:Roundabout binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000080">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF4">
        <property type="entry name" value="PROTEIN SLIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="503"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001018401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="590" mass="65166" checksum="22D338CB2D69BBC1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA79</accession>
    <name>A0A0R3XA79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAP1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10439</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021703">
        <property type="protein sequence ID" value="VDM35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA79"/>
    <dbReference type="STRING" id="6205.A0A0R3XA79"/>
    <dbReference type="WBParaSite" id="TTAC_0001045601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001045601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001045601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067624at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitochondrion distribution"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HAP1_N"/>
    </dbReference>
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        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
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        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF12">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN MILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001045601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51473" checksum="0580B950CB02C967" modified="2016-01-20" version="1">MCCYHSQQRDEQQTVTLKECLRKLGDAMVYMKNLSDEQFRRSDALMQQQNQVNALAARSRELENSLNQVGLTNEMLASKVEELDTVNQNLVRELRDMKDKYDESLILYTQAQATVRKLRDRSRRASLRPTRLLYSPLGSRQGTDILPSPLPDKPLSIADELALSSSHEKSTQSGAARCPPDHRSFQVAGDNVEMHPDHAASRTQKGTDCTEWDDPTIDNPIDSAHRASGGFTEDVSPPPPDSQLLALQHGIDWDVDREPEIEEDEDESSEVIRAFTQHHISSQPTSTDRAVRRPKVSDVQKLSPSSHEPSTNRRSWVIDQNTATIPPQHSFDDSTLGSTGPTSIFAQAVRPQRLQLVKQLQGSGVLQRWQRLATPSLTAALYEGPLSGVASRSGVLFSDPFNATSIAPVSSSIPLRWASGADLSKFHFSLCHRIYPHPYITTLTFYSGSGRIRLLPLRQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAW5</accession>
    <name>A0A0R3XAW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10675</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022031">
        <property type="protein sequence ID" value="VDM35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAW5"/>
    <dbReference type="WBParaSite" id="TTAC_0001069201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001069201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001069201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001069201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5707" checksum="777000461090FD56" modified="2016-01-20" version="1">MDRYRVLSLIGEGAHGVVLKGRHKEVFVIFEIFCSRVNLLLLKRFLFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBR0</accession>
    <name>A0A0R3XBR0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10971</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022632">
        <property type="protein sequence ID" value="VDM35951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBR0"/>
    <dbReference type="STRING" id="6205.A0A0R3XBR0"/>
    <dbReference type="WBParaSite" id="TTAC_0001098701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001098701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001098701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977959at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001098701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15987" checksum="5776B33EFE1DD499" modified="2016-01-20" version="1">MDSILHGVEYGVRNGHKLTHASKKPHGCQFCDKSYSDARSLRRHYENAHPDEYESWCFLSRAAEEGEASIAEAVAKMTQLSAAAVTSASSTTSNGNNLAQQLVGVKVADTLRCHTAFLFILEDFVNLEGRLRYSLESHFLPQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDB3</accession>
    <name>A0A0R3XDB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11523</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024653">
        <property type="protein sequence ID" value="VDM36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDB3"/>
    <dbReference type="WBParaSite" id="TTAC_0001154001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001154001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001154001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001154001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32558" checksum="B84CBEE69DD6B97F" modified="2016-01-20" version="1">MRAAATIARRAFHSADQVSKNPEEGGKIRTAISPALQKAACGGTAPSPDFIEVILGWQVRHSIRGCFHSWMGKREVRICGGRVGSNIVPCIKLVRERNLPMCAYCNNDKRSIIEYERKQERVWKGATRVWVVGGDAHLQLLWLIPYRIGAIPLVFCQFVMRSRGCLEEGGAYHLDKWCRREGKRSGTGQEKVDEEAAPPLLLSLLLPAYATTSAVMLESDCTPHSHLSMHSNTVNQPVKAFLPPHCLQKRDLGFRHLLYHSTRQMTVVMRVNACDAKPITTGCEIVNAAKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDF4</accession>
    <name>A0A158RDF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS532</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000049">
        <property type="protein sequence ID" value="VDM16591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDF4"/>
    <dbReference type="STRING" id="6205.A0A158RDF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000053101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000053101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000053101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="13">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="212"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000053101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115639" checksum="2AD797C6BE6F5161" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDI3</accession>
    <name>A0A158RDI3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3437 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS676</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000076">
        <property type="protein sequence ID" value="VDM16820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDI3"/>
    <dbReference type="WBParaSite" id="TTAC_0000067501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000067501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000067501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="1980"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000067501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2062" mass="230662" checksum="CFC6D1EF9FA72EAB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDM8</accession>
    <name>A0A158RDM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil alpha-helical rod protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS996</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000151">
        <property type="protein sequence ID" value="VDM17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDM8"/>
    <dbReference type="STRING" id="6205.A0A158RDM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000099501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000099501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000099501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253628at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000099501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="70023" checksum="2689C0689B6DF147" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDM9</accession>
    <name>A0A158RDM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1004</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000153">
        <property type="protein sequence ID" value="VDM17295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDM9"/>
    <dbReference type="STRING" id="6205.A0A158RDM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000100301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000100301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000100301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF23">
        <property type="entry name" value="FURIN-LIKE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="13">
        <location>
            <begin position="430"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000100301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="849" mass="94204" checksum="578AE5C8D8B4E11F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE62</accession>
    <name>A0A158RE62_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centrosomal protein of 162 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6678</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020315">
        <property type="protein sequence ID" value="VDM30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE62"/>
    <dbReference type="WBParaSite" id="TTAC_0000669301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000669301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000669301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6351660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000669301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="705" mass="80564" checksum="E7377D2C6CC68E16" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REM2</accession>
    <name>A0A158REM2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7558</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020383">
        <property type="protein sequence ID" value="VDM31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REM2"/>
    <dbReference type="STRING" id="6205.A0A158REM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000757301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000757301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000757301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000757301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37147" checksum="C97AD636EF539EB6" modified="2016-06-08" version="1">MGKSSRDKRDIFYRLAKEEGWRARSAYKLLQIDDEFKILSKDHNGNPLTRVVDLCAAPGSWSQVLSKKLWEPCAEADRQKVKIVAVDLQAMAPIPGVIQLQGDITSRQTADQVIQQFEGEKAQLVVCDGAPDGTQPLLTGLHDLDEYVQSHLVLAALTICARILENGGTFVAKVFRGREAGLLGAQLRCLFAGDVVFAKPSSSRNSSLESFVVCREFRGDTVLPSSLTSTSLMDHKSGDDSGDSLMGWLSGLDQLTPEQRILLPFVACGDLSGYDADSCYELGDNYTLLEPVQPPLSAAYQDNCRQARIVTPGNMKQRDNRKVDEILSQQMKEMQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REN4</accession>
    <name>A0A158REN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7652</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020391">
        <property type="protein sequence ID" value="VDM32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000766701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000766701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000766701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="896"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000766701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1441" mass="161590" checksum="81DBC60728C3BFD4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REY7</accession>
    <name>A0A158REY7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8354</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020489">
        <property type="protein sequence ID" value="VDM32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REY7"/>
    <dbReference type="STRING" id="6205.A0A158REY7"/>
    <dbReference type="WBParaSite" id="TTAC_0000836901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000836901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000836901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000062">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000836901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="39859" checksum="07C115132B9781E7" modified="2016-06-08" version="1">MDGGGVTSSSADKSATGQRRARQEGSNDSDPSGSQPPPQSSSSSDNTNGSFECNICLDQAQDAVVSRCGHLFCWPCLHQWLEVKKSRPVCPVCKAAVSRDSVIPLYGRGADHKRDPRDKVPPRPQGVRTEPESQRVSSNLYNIFGGNAREEGEGSGGNLQVSFGFGPFPFGLFATTFNIGGGGGVFCLSSSVMVRIKYRYLISIVSVGAPFDGSASRSVTHRPAYPGCHTLSSSTSVISSPDVDTMIYRAIRRSVQTAHGTFGVGRLMTRFRIIYWNTSSGLLIIRVLRGLPTEQLTSALSLITSVYDGSVERPAVIDVVHRSGTVRCCQKFIGEYYKVQLSGSIWGVRETAIARAAANRLIEAKPPDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EEQ6</accession>
    <name>A0A3P7EEQ6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001647">
        <property type="protein sequence ID" value="VDM21450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EEQ6"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="139" mass="15894" checksum="D7CF430BA532535E" modified="2019-02-13" version="1">MIDGSKDGIIDQGDLEEVFRSMGKNPSEEYLDEMLKQAPGCINFTMFLTLFGEKMMGCDPEETILNAFAQFDPNNTGVISEERLRELMTTMGDRWTDEKVDELFHGAPIKNGDFNYREFTKMIMHGQQDDEDQSHPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EMN6</accession>
    <name>A0A3P7EMN6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003883">
        <property type="protein sequence ID" value="VDM24400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EMN6"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="374" mass="41624" checksum="F6C743F265EB75CE" modified="2019-02-13" version="1">MSTVFALNSFQSCDLNGVRAYSTLDQSGVCTLGTALVDYRGYRVTAQTIIPGKLSVLSAGILEKEQDQLIVYGSNDFGKSVVADKRYAEILGKSAKALRIRPHKVLDKSGSVVNLLSSVDCKGIVGNDNRTYLLDLLNTFPPDVNYLGGAPAPVRPVLSETMRKLGYPYVHRHLLPSVRQELVDFFCNLRQEEFVRKAAEEFHKIRTTSTDAEKELVKSDEREDKGPNIDVNGVLLLDSDSSGKSIQQFMIQEKNFANSQHSGAVGTTLVSKIRKAMTEGTDDLDLKEAMKRAAQSIKTFKHGSFEILFNSDAFKSTVTFAKEEEENLKRDRELIQEICEFLVLEQIPAVIDDCVNFALIPQDGRALVEILHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EP47</accession>
    <name>A0A3P7EP47_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001698">
        <property type="protein sequence ID" value="VDM21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EP47"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28087" checksum="12579B4EBA4F9865" modified="2019-02-13" version="1">MPQAFLSSNWSNTLMYITRLVTILSCLLFFLGTPFGNTYPWYQRALIANAATFALRLHQRIAQRGNQPRLSQESMQLIVSEDSLHYLLYSVIFLLTPPVTVALAPIFCFAFLHCLGFTQNLLMLYAGKSENPSILTKKILDCISMAQGHSDNVLRIIAIHEILLMVISIVLAFSGRIPLLPFFYYHFLKLRYTSRRNPYCRRVFSELRIAFHQLADHPNCPQFVRSIIRGTVNFISRLSPSEHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERZ6</accession>
    <name>A0A3P7ERZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005952">
        <property type="protein sequence ID" value="VDM26070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERZ6"/>
    <dbReference type="OrthoDB" id="10585045at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="212" mass="23814" checksum="42EECAC05800C0C4" modified="2019-02-13" version="1">MIKERERHPGSGAVRQVTSPQQQQQHHYPQQQHTAYQPQQQQSSTSSQFSRGPKLGVTVATANAKQQQQQQQPLSASNEEKFEDTAHHFPMQQQQQLRSAKQFFVGSTNNNGADAPPSRHQNIMTPKFPPVRTSVESRTGSGNVLSDMRRPLDLSKQHSHSHHQLQQQQHHPLSQTSGSGGGQNYLQRTNNNGTPTRQQPTVRSQSQFCKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EX33</accession>
    <name>A0A3P7EX33_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS4278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004062">
        <property type="protein sequence ID" value="VDM24586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EX33"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF126">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM24586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="486" mass="54610" checksum="A65A13AEBE7CE026" modified="2019-02-13" version="1">MTVFHEIGVDPCLYYIALGESLFNDGVTLILFKIVQQFLDSKSVTAKGILIGLGAFLTISLGAIVIGVVLGVLACIITKYRTHFEVVFLLGVAYTSYILGDVLGWSGLVALITCAMIQAAYAFHNLETNDLYTLRSISRQLSEICEGIIFLLIGIKLLEKQLYWHMSFNLWSLLTCLVVRALVVFVLSLYINRFYLNISTISLTEQFILAYGGLRGAVALSLAIMVDKQKVEQRVYDTLVTSTLFTILFTVGVMGPTMRPLVKILHIKLAQRKTISLVRVLNERMIDEIAAGVEGIIGRYGRNSLRAYFVRLDEDYIRGFLQRQPSSHNAGIVKVYEEMALVLHLASLRSPQQAASIMRDLPATIQLRQFEAINMEHEASRAEMQKMTQFSAAHSFLGVMRRRNATLYLEDDCGTAPHRRGLQRFSFLCEMPKLLAAKRVQILSLSSQLAETTPSDRNADARPQEEAEKENDRAKKGRRSRNVINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F0T3</accession>
    <name>A0A3P7F0T3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008157">
        <property type="protein sequence ID" value="VDM27303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F0T3"/>
    <dbReference type="OrthoDB" id="10529811at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="117" mass="13166" checksum="411AFF10C20FE45D" modified="2019-02-13" version="1">MVNVNIHAEEELRFTESIYNFSAVTYSNVGAICGKVTVMHETYAPPIALVDYQCGYSLLAGDMVPFTVDSHGKTNFNDSRDTGFVSKYHLPGGKRYDHKHLVLLCHNNNLWVCNICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F646</accession>
    <name>A0A3P7F646_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003527">
        <property type="protein sequence ID" value="VDM24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F646"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="137" mass="15319" checksum="47F76B7B0BCC675A" modified="2019-02-13" version="1">MSNHEHNFIEVLECSKGLSKQSNRPQHLENLIAYGADLNARTLRGQTPLHLCVSHEANACLSLLLQRGADTSQVNNDSQTPLEYALLTNRNEQVKILQDFNRADIGKAKEGGDFPNALLLRDVRQSFVAQKLAVIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FW08</accession>
    <name>A0A3P7FW08_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 199</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020412">
        <property type="protein sequence ID" value="VDM32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FW08"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19318" checksum="905A420603AE789E" modified="2019-02-13" version="1">MVAGESLNPLQRKDLDVFYRQEIHANMKALGVMNLPPLWKVVRSSGIVLPEPCVPPRDIIVQQRVESLTRKFANMDYGRMTKHLPQLGSTARYKSVMMIINFVLVVIGSFIFGYFSYATPVQRIACGFTFALFVFFADLYFLLKNMEACELKAFPPSSNHTLSQSNVILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G3Q2</accession>
    <name>A0A3P7G3Q2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS894</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="UYWX01000122">
        <property type="protein sequence ID" value="VDM17142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G3Q2"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM17142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="469" mass="52919" checksum="AE5080950E9D2878" modified="2019-02-13" version="1">MRQLHDDVNVEVATVDAAAVASAAPRAGDYSSTDEAIETPLASDLDIEPDAAEKVPHGSDHVPVFLETSVAGLSPRLTNCIVRLFMSIVMIGGFLFLIYLGPLALVLLVLCLQLACFKELIHIGHVVYRTHNLPWFRTLSWMFLFTSNYFFFGESLIGRFRILLAKEDFLAPLVVHHRFISFTLYCGCIVAFVLSLVRRHYLKQFTLFGWTHVSLLIIVSSSHFMIQSIFDGLIWFLVPVAMVISNDIFAYVFGMLFGKTPLIKVSPKKTWEGFIGGGISSLLLGLLVAWSMIDKKHFICPIEYDDRMGALSMDCVPDAIFIPRMYNVSRWLFFVPVKQVAWYPYFFHCILIGAFVSIIGPFGGFFASGFKRAFKIKDFGDVIPGHGGILDRFDCQIFVGWFIFFYYNSFVKPLTPGSLLQQVFVLPRHEQLAVLNLFLDGLLRRGHVPRELAEPLIAYGEEVRAIEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHN0</accession>
    <name>A0A0R3WHN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS56</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000003">
        <property type="protein sequence ID" value="VDM15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000005501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000005501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000005501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279878at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000005501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="32880" checksum="75086FD33D8881F3" modified="2016-01-20" version="1">MSGQDSHLFLSKPTATPGVSRPSKLPLFGKRSSEKHPPSASQPPVSSAFATSSLGRVRPSTVVRPFFAAQFQSTASNDAQRRRYPASQPSTPVRSGQCEMNQEFQQLHHSARATSGSATPKRGEAGGVIPQSISFPGSRHAVGNQSSKSSRSKSYRMENMSVEHLQYLERRLQQLLEIMPFRPVLPAKAKSDSGRQSAHPSWVSNVHHHLHQHQALHYPVVATPLHYHPPTAPLLLFPPQSTPQPQPPSASQLPPPHPTVSASGFGEISSYYLSSSPSSASSCYAGSAPSSLQDFNRDEVNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WID7</accession>
    <name>A0A0R3WID7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS357</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000028">
        <property type="protein sequence ID" value="VDM16301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WID7"/>
    <dbReference type="STRING" id="6205.A0A0R3WID7"/>
    <dbReference type="WBParaSite" id="TTAC_0000035601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000035601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000035601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000035601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58792" checksum="049D192426E8EA50" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIK0</accession>
    <name>A0A0R3WIK0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS431</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000036">
        <property type="protein sequence ID" value="VDM16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIK0"/>
    <dbReference type="STRING" id="6205.A0A0R3WIK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000043001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000043001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000043001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73004at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF86">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="5">
        <location>
            <begin position="459"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="5">
        <location>
            <begin position="562"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="834"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000043001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="865" mass="96086" checksum="14B44BC08F23FC95" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIR3</accession>
    <name>A0A0R3WIR3_HYDTA</name>
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        <submittedName>
            <fullName evidence="4 6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS504</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000045">
        <property type="protein sequence ID" value="VDM16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000050301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000050301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000050301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132857" evidence="3">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
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            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000050301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26892" checksum="10199BAB900C483D" modified="2016-01-20" version="1">MFCPQSTQFSLFLWIPFWRLYLIFDPQTPFLENEGDSEEVMELVLVSEEVESSESSSLLLPSALSEDEVESESHVDDGDDDDGDDDKDDDDPYDEVESEFEEVSESEVLLLEDVFWEAFAFFEKSVCVCLPLVEGLCEEEDDDVEEDEEEEEEEEEEEEEEDVEEEEDLRCLSEVFLTRAGCFLLSAFISEASTSAFFLVIVFTTTVSYCLQTHKKFELMASAIGCDAENLSKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJC9</accession>
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        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 150</fullName>
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        <name evidence="3" type="ORF">TTAC_LOCUS774</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM16974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0000077301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255335at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000077301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="790" mass="89908" checksum="CF3946BB9041C61D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJD4</accession>
    <name>A0A0R3WJD4_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">SH3_10 domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS782</name>
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    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000097">
        <property type="protein sequence ID" value="VDM16985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJD4"/>
    <dbReference type="STRING" id="6205.A0A0R3WJD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000078101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000078101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000078101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276841at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000078101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44964" checksum="EF7A03E175ECB8D3" modified="2016-01-20" version="1">MSMEVNNDPEENVYLFHEPNQQESILRHLLDQSCPCGQASEDAEKILHDTQKRIENNIESLDYLRGISRLERDFVHLADKVVQTSLHLSHDCRNINREALDSARLNEEVGNSWEHITHLGYMLQTHVNHAKRYHLFHLELENLTRQVDELEAHVDDLKVHQAATESAINTFCKEIRQSLEFFVEAFMNWQKLNSQLSIVNPLHRRMPLLHGLHSGVLMASISLSSANGKVGRFLRAGTRVHVRANRPADLMHREWFLVDPSKGMEPGGMVIGSVPAAFVWLNSPETSPERAETDDVMVRREVEIRRSQSTSAIPRRLNNLVMVKDQDQMACHPESSQTLSNRKASEAMDIVRQKFDSLDRVHVMERRLIKDFVVKGCIALAFSPLRVDPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJI8</accession>
    <name>A0A0R3WJI8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1908 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS838</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJI8"/>
    <dbReference type="WBParaSite" id="TTAC_0000083701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000083701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000083701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262882at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000083701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15703" checksum="4D14A95AEDD10A52" modified="2016-01-20" version="1">MASSSSSSTSTRYNQIRLRRISLNAENLGHQPKAVGLHLRRLREPVYSRKYSDRIFTHTHLSGIKPSPPDCHEISGQVSDSTSSLGEDTGEFDFSDVHSSCLALNPAPNRRTSFLYRPDSSDDASSYSSRRPSVSCGDPMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ1</accession>
    <name>A0A0R3WJJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS841</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000110">
        <property type="protein sequence ID" value="VDM17063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJJ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WJJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000084001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18120" checksum="FB75BFD684B3FAB4" modified="2016-01-20" version="1">MDGDGDGGDVEGGEEEGEGRGGGKGKVEGGRMNRSEVNRPEKRPSEALLGPGRLSDSHRSSAASAASVSSPFVPSILGANGGVTGLGVDPKKVVQFEDLPEPPPHYGVVPEHSEEISEVLGLCVTNILDSTLPKLDEVFVCPRIQEDYAKENMLKHADGESVRTTCDCEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJL8</accession>
    <name>A0A0R3WJL8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS874</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000117">
        <property type="protein sequence ID" value="VDM17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJL8"/>
    <dbReference type="WBParaSite" id="TTAC_0000087301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000087301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000087301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674273at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132842" evidence="1">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000087301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24900" checksum="2B16E88EE72B7385" modified="2016-01-20" version="1">MAKLICTLLLVSLVASEAPTEQERKDLLDFHNNKRATVNPSATNMLEMVYSAELEKLAIDWVAKCKFEHPNSSQYPQYNGIGQNLALTGGVGRNLVSQATQWWNEVSGYTYGSNACTVGTVCGHYIQMVWATSEELGCAVKQCDSLMPNWPSPVFLLTCQYKPAGNYIGIRPYTSGISCSQCPVGTTCVNKLCSRRNSNRSRATSSSTVTEMGQITLFAAIMIYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJV8</accession>
    <name>A0A0R3WJV8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Guanylate cyclase</fullName>
            <ecNumber evidence="2 10">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS977</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 10"/>
    <dbReference type="EMBL" id="UYWX01000146">
        <property type="protein sequence ID" value="VDM17259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJV8"/>
    <dbReference type="STRING" id="6205.A0A0R3WJV8"/>
    <dbReference type="WBParaSite" id="TTAC_0000097601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000097601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000097601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000013">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF462">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132851" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="330"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="761"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000097601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="954" mass="107110" checksum="BD5911848071E372" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJZ8</accession>
    <name>A0A0R3WJZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1025</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000159">
        <property type="protein sequence ID" value="VDM17327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WJZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000102401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000102401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000102401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10050565at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="205"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="9">
        <location>
            <begin position="410"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM17327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000102401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="605" mass="68107" checksum="60CA26106344EA20" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKA6</accession>
    <name>A0A0R3WKA6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1143</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="EMBL" id="UYWX01000194">
        <property type="protein sequence ID" value="VDM17533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKA6"/>
    <dbReference type="STRING" id="6205.A0A0R3WKA6"/>
    <dbReference type="WBParaSite" id="TTAC_0000114201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000114201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000114201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM17533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000114201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37002" checksum="48870421B43FC6AE" modified="2016-06-08" version="2">MVLSKRIQTQSDMGAWAASLAYASIIDFIESVNYASVSKVVGLLNLLDAQVELTPLEINPQRYGNRAFQKYYSWLCENASHICAGVLEIEPSTVITYLTESVGNPVRIDYGTGHELSFIAFLLSLFKIGYLKQVERVGRGLQGGSSTELNDYAATALYILPAYLKLVRHLQTYFRMEPAGSHGVWSLDDFQFVPYIWGSSQLIGTGLYEPSAVPDQEIAEKEANSCLLFSCINYIFQVKTGPFAEHSSCLQSLSSVPSWEKVNSGMIKMYKGEVLNKFPVVQHFLFGNILKFEQALSTPDAGPPGRFRFPGTPGFGHCLSTRPRPPFVKPTGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKQ1</accession>
    <name>A0A0R3WKQ1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1299</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000251">
        <property type="protein sequence ID" value="VDM17761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WKQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000129801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000129801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000129801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000129801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42719" checksum="9E4AD6294411563F" modified="2016-01-20" version="1">MNGQTEVADEVPSTDTSSKEVIEVEKPMKSSPSEPVEADINETVEPAQKRRKLSKKERYIQRKEERREKRKAVKMRRRARRAEKAASAAAAKDISPRAPPPPPRVSMAESKCKTRVVLDCAYDHLMSLKDTCKLAHQIAYCYSTNRHLPAPVQLYITGLGSAFEIKEGTEQPAELREPKEQSTLARLRRIGAQNWDIHLKMVICAISFVTNQFHLYPSPIFVVHSNHATSKELCLEDYRELFPASSIVYLCAESKNDLPDTFVPTFTCTGATAADPPDGSATTAIEDISSPTNTTPPVFTVDDVYVIGGLVDHNHHQGLCYKQALQRGHRTAKLPLERAGVTVEGRRVLSLVHVFQALAFVLSGAHPQWHDALHAALPPRKCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKU4</accession>
    <name>A0A0R3WKU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1346</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000271">
        <property type="protein sequence ID" value="VDM17850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKU4"/>
    <dbReference type="STRING" id="6205.A0A0R3WKU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000135901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000135901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000135901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000135901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15034" checksum="869F274F5011473D" modified="2016-01-20" version="1">MHKRLSWTTLQGCFAILMACCGLAPLGHLTTLANVMPYLASYMHMYTDVSVDYSLAIWLSCCLHAIQGIATPTTAVLISRVGYRPLLLFSWIVHRYVNLCIGHSGRVGERRGKVRFYAFCYPLLYVFISESYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH2</accession>
    <name>A0A0R3WLH2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000396">
        <property type="protein sequence ID" value="VDM18266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH2"/>
    <dbReference type="WBParaSite" id="TTAC_0000161001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267507at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37944" checksum="65A3F18A408588EB" modified="2016-01-20" version="1">MAKTVKTIRAMKRQTVEGGSVLYNIPGVDRSDSLIDMIARMKDVSQSINQEGSTASICEKGTASLMSLSDVMKANKCNRSIRSVLLTHKLMNELQGEAMKAFVTAMKSQQERRKRLDQQTREFETRRSNFRQIIIENINKINRQHEVFKAMRSEYTQCRETLHELIIATRSVRNRRVMRAVVLPRSTGLGQPKHYVSKSHDPLRSLMLRYQSLMEARNHLLEAWEEKQAQFEKELLQSTAASRNQKQVVIKRVANVHDVLGEADGLYDQIQHSNKTADEERASIALQLNEFNMMSRSIRNITAKCVDMLKDLEYHQPLPSPPEACLTQPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLM7</accession>
    <name>A0A0R3WLM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1652</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000430">
        <property type="protein sequence ID" value="VDM18344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLM7"/>
    <dbReference type="STRING" id="6205.A0A0R3WLM7"/>
    <dbReference type="WBParaSite" id="TTAC_0000166501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000166501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000166501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="2">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000166501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="30806" checksum="0FEBCF6C8D87E970" modified="2016-01-20" version="1">MTVDDICYLVGDMVDLYTNHCQHRSASFSSSFNTLEGRQSSPQSLSRSTSIAAYLLRLRALNISGAVLTVCSLNESLRREIGMTFSDWQIFSTLITYLKRLEGRAPTPPSSVPPPPPHGCQCARSMGDLANIHTHRHHFHLAQHKTPVLCRPNVGAWTSESILAAATPHQHWHHPRDSSPSPINGQSSASISSSSSSMDTTTCTSNSPHWHGPKPHLPPPPPPPPPPPPQQQIIEEEVCRLSGGSCSIYSAELSYSPSPSSSAVTVPSASSSPSPSISSLHSSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM13</accession>
    <name>A0A0R3WM13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Caspase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1788</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000510">
        <property type="protein sequence ID" value="VDM18528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM13"/>
    <dbReference type="STRING" id="6205.A0A0R3WM13"/>
    <dbReference type="WBParaSite" id="TTAC_0000180101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000180101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000180101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF210">
        <property type="entry name" value="CASPASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="78"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM18528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000180101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34583" checksum="F2CFAE0591AC0C4F" modified="2016-01-20" version="1">MCSSLTASSSAGGKSSPTLRRTASPCHASPPLQKSVKPAEVMTGTGSSDGRRYLSEVELCDPDLGYPRVANPNNRSNPRGVCLLINQRDFDLAKTGQERRDGTDVDADNIERTFIRCGYAVNRATNLTLRKMEFLLDDVRSQNHTKYDSFACVILSHGAEGIVYASDGTINVDRLIGYFRSDRCPTLAGKPKMFFIQACRGCKFDKGVALSTDANSDYVLVTKLPIEADVFVANSTFPGYYAWRNSQAGSWFVQELCKVIKAAQESGRHHDVASLLTVVARKVALLYESNTGQSDSHGSKQMVSINSTLTRKAFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMW0</accession>
    <name>A0A0R3WMW0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vegetative cell wall protein gp1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2085</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000742">
        <property type="protein sequence ID" value="VDM18869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMW0"/>
    <dbReference type="WBParaSite" id="TTAC_0000209801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000209801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000209801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000209801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16142" checksum="2C260173E6C2FE95" modified="2016-01-20" version="1">MPSSQPTLVSHRHIKCTPSFLIRFLFPFLSPPLTTLLQPPSLPSSLPSSSPPLTTLLQPPSLPPSLPSSSPPLTTPPPLASLHAKTFPPPSSVSTSSSSTSASVRLLLRHHPHQAVLNMPPPASAPGNVTMHWHPHSLRSHLSGSHVAWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN44</accession>
    <name>A0A0R3WN44_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Separase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2169</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000817">
        <property type="protein sequence ID" value="VDM19112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN44"/>
    <dbReference type="STRING" id="6205.A0A0R3WN44"/>
    <dbReference type="WBParaSite" id="TTAC_0000218201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000218201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000218201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64340at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038751">
        <property type="entry name" value="INTS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057980">
        <property type="entry name" value="TPR_INTS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS8 TPR repeats" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000218201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1091" mass="119557" checksum="95FF88C6A44DA5E2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP08</accession>
    <name>A0A0R3WP08_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2483</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001128">
        <property type="protein sequence ID" value="VDM20177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP08"/>
    <dbReference type="STRING" id="6205.A0A0R3WP08"/>
    <dbReference type="WBParaSite" id="TTAC_0000249601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000249601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000249601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000491">
        <property type="entry name" value="zinc finger matrin-type protein 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM20177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000249601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22368" checksum="4345B78BB016C9C2" modified="2016-01-20" version="1">MCADHRRKWDRAYFEKLADQRSTEELEALRNARTEKETVKRQPLKAREYTIDLESNLNKSQVIAKTGPGSSQAGYYCEVCDCVVKDSINYLDHINGKKHQRNLGMSMRIKRSTLEEVKGRFSMHKKAQEQKAQEYSLDERMKQIAEEEEKVKAYRRERRKEKKRKAEDPDLLDEDVAATMGFGGFGSSKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPF4</accession>
    <name>A0A0R3WPF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shugoshin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2629</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001303">
        <property type="protein sequence ID" value="VDM20715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000264401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000264401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000264401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260638at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000264401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="535" mass="57752" checksum="CB0B97BE04199277" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPJ5</accession>
    <name>A0A0R3WPJ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2670</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001357">
        <property type="protein sequence ID" value="VDM20837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPJ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPJ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000268501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000268501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000268501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000268501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42057" checksum="04DAFB6CCA691637" modified="2016-01-20" version="1">MLASLPDGSRILVAAGSVVACFDQGVCMTRNLKKKVGCLAFMPDEQSVLLGEKSGYVVRVPLDGNKSNSVQIDNEDTLIGHLSLLTGIALNKEGRLLGSCDRDEKIRISRSSQPHVIESFCLGHTKLVFLVFYPLTRSIFGIAFLDDNHMVSVAGDGFVRLWHALEGQELDAIKLVPHLNSIRGCVMDNENQEFLAPRLIIIGCTIVLGVRSHDCIVTVKLSEDFSTFARDDTNDAFVSGVLCPRNEHFVDCCVVNHRITEKDFEVVCMTEPLSRFVSWTVVYCRDSALEWSQMREWDALPPELTTENGWFPRLQMLMEMGKSFISMSGVDAYERSKEEAHKRIRDRHQRHQAKRKRQKVMANATPVEGKGTPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPL2</accession>
    <name>A0A0R3WPL2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2687</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001378">
        <property type="protein sequence ID" value="VDM20879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPL2"/>
    <dbReference type="STRING" id="6205.A0A0R3WPL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000270201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000270201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000270201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000270201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15499" checksum="E5DA86FB0746B6A3" modified="2016-01-20" version="1">MRLALDQMTHSQRVRFLYKMLLRTHKALPPELRELGDRYVREEFKRHKNCDSIYIGPFMMEWTRYLVDLNKQIRSAMKVEGEEGSEYVPGFGAHLKEGDLDMFSEHQLKQLLALADELHGVNQSDGSKTQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPM9</accession>
    <name>A0A0R3WPM9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">TTAC_LOCUS2704</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001407">
        <property type="protein sequence ID" value="VDM20938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPM9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000271901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000271901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000271901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000271901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43556" checksum="DB2D2022828CB424" modified="2016-01-20" version="1">MLNLAVYYQWVPFVLGLQCCLFYTPRLIWQAICYNRTGTDLENLVNQAVTAMHSDGKGRQGAVDTIAEGIEHLLFQGQKRAMLGREELRGGGRSATDSEGEKMLDYAGEKHHRRNFASQSARLRVLSKRRGNYIVLTYLLIKMLYLANAIGQMFLMQHFLGFNSTSSPLFGFSVLKNIINGHDWQMTQIFPRVGFCYAEMKILGVRVNGVTAQCALPVNMLNEKLYIFLWWWILAAAIITAIYLLLWIIRICAKSREVDYIIKYIKFADDVPQFDERDVDDFALRFLRHDGMFLIRMVRLNAGDVVASGVVNALWNRYQERLESGNRDPLTNNLRSNVGWSASLEKGGDDTTVRNRAPEMPSVDSTETPYPHQPRSIRTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPQ6</accession>
    <name>A0A0R3WPQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WIF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001439">
        <property type="protein sequence ID" value="VDM21010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPQ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000274601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000274601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000274601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10026202at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132940" evidence="1">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000274601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42273" checksum="CE3091BB9390CFB5" modified="2016-01-20" version="1">MVGGRKTLFLLWILFLVVHTIEVDVINTKFVPIDAAFFTDIGSTKETSIYMQDFASVGNIDDVSLNINVGNLRVKASINPDANNFYTHPLTTVHLFQKELGEDDPTLHFLCHSLMAPDLLKSLNNQHMSTCCIIKVIASNRHFFTGCLIDNLSFTNRSACHASITIESRAWNDSMNNELDVSYRINTVQYMKSSTVNLLMDSAALSRQCWTPLATQMSNFKFLSKISLKKPQQDEIREIGRNIRLDIPSRRLKNGEYFNVPVRVKQHASIAEFTLRCEIPSKTYIEFVRVVWPWEVDESSSNIRDTSDRLLHLNNGFSAWDISQRHIPSSKGNVTEVVARYRETAIDPSLNDHFRFGFSAESCFKHFYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ46</accession>
    <name>A0A0R3WQ46_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2870</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001613">
        <property type="protein sequence ID" value="VDM21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ46"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ46"/>
    <dbReference type="WBParaSite" id="TTAC_0000288601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000288601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000288601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000288601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26205" checksum="43C7A37BB1667EFB" modified="2016-01-20" version="1">MLSSEVSYVQVCEDDGTPVEIPLEDDKTLLLSTLAAQFPRATGLKYTSESGCMRGVRYSDGRIYPPPDGWQNRVYKIVVSYAKRKVDDEEAGNFAKTKRLDGKRCTDLIVLNLPWRVEETALKNYFSRFGDVVMAQVKRDPNTNQSRGYGFIRFRDYDAQVMCLAERHFIDSRWCDVRIPISKTEGDRQEVNRKLHIGQLTEDITADMLRDHFSQFGHVSFLWSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQB4</accession>
    <name>A0A0R3WQB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2939</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001706">
        <property type="protein sequence ID" value="VDM21557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQB4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000295401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000295401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000295401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000031">
        <property type="entry name" value="tubulin beta-4A chain isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527:SF3">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000295401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12379" checksum="348D0B24517E8A66" modified="2016-01-20" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGTYHGDSDLQLERIDVYYYEASNGKYVPRAILVDLEPGTMDSVRAGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQL6</accession>
    <name>A0A0R3WQL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DJ-1_PfpI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3041</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001836">
        <property type="protein sequence ID" value="VDM21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQL6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000305601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000305601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000305601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000022">
        <property type="entry name" value="protein deglycase DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000305601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19369" checksum="F52844C4BAD04917" modified="2016-01-20" version="1">MTKTALVLLACGAEELETIAIVDILARAKVKVVVAGVGGPSVVTCSRGAKIQPDVALADVVGTAFDLVYLPGGMEGMRALSKSADVGKVLKDQHENKRYIAAICAAPCALKAHEINKGAKVTSYPSLKGDLEAYYTYLDETIVEDGHLLTSRGPGTAIVFGLRLAELLTDHATAKSVATAMLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRL0</accession>
    <name>A0A0R3WRL0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="7">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3385</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01002350">
        <property type="protein sequence ID" value="VDM22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRL0"/>
    <dbReference type="STRING" id="6205.A0A0R3WRL0"/>
    <dbReference type="WBParaSite" id="TTAC_0000340001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000340001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000340001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000340001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36793" checksum="228A0FA325F557E3" modified="2016-01-20" version="1">MESMSSESIQYTNDEATATKAYAVRVGYWSDPYIKIFCPIPSSSTPEISRGYYVRVKAFEAIVNRFIQECNRVCQIVNLGAGSDTLFFRLKDKDLLPKVYVELDLPGNVRKKIFTLQRNKVLQAALPTGDSAFPPSAVPKDRISFGCYHLLSFDLKASPSSLISLLCDSSDGPSLSPALPTLFLAECVLVYIPTEFSNSLLSALSNKFRQAAFLNYEQVNMQDKFGEIMQSHFRDRSCELPGLAACGSLEEQRSRFINNGWAEVRAWTINEVFSSFPQDAISRISQLEMLDDTEITQQLYDHYCIVLATNTAAICQWISLKMALSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRN3</accession>
    <name>A0A0R3WRN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002387">
        <property type="protein sequence ID" value="VDM22570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRN3"/>
    <dbReference type="STRING" id="6205.A0A0R3WRN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000342301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000342301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000342301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 2 TPR repeats" evidence="1">
        <location>
            <begin position="246"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000342301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48031" checksum="4A849C3272BB7F58" modified="2016-01-20" version="1">MTPASELFELVQSGLHIEYPSVFVECALHHLCSTCIPAFRELKTDYPTASDVDPFEHAVCMLSDHLPAFIRLFQWFQLVQVNTQSLYRLIAQNLPSSPQRSCFEVAVVGDLFTPDVYHTLKPYLYAYLLLELNAAEQETSEHNCFEDSLTTARLLVRLSTSVTDLIEQCRGVFAAEEFSLLFLLEDLVVPFAESVFLHKTRELMEGHYTVSFLEPLHDYVEHVMFKAWLPRVFRITSSCASCPWSSQLVYTTFYSVRRSELFSIMMDYPDSHPTVMDLKAYLMETRALQDLIDTLSKEVGSRLLQPGVHTDEVLLAYGCLVRGLREIDPSSVAQDIVCRPVASCLRERDDAVRCIVDRLIAPPQLSTIPDATTDTDTNVADVVAADQITGLQRELLLPTPLEVEPTDEMRDCDAHLVAHGKSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRS3</accession>
    <name>A0A0R3WRS3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3448</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002449">
        <property type="protein sequence ID" value="VDM22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRS3"/>
    <dbReference type="STRING" id="6205.A0A0R3WRS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000346301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000346301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000346301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000346301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41983" checksum="BF7796C30D66C441" modified="2016-01-20" version="1">MSAYLRAVGLDFSEKVVRQRPTSSISFVVALDRVITTPLLTRIKVVDKCLLEHFVMELKLLDHLCFVKSVFCHEHPVITPRVLDALFDELSSPGEVRSVFNDTRRFKDLIPADLLNIKFLRQEMQINTSSPFDTGFQHLLFYFKQLPTVQMADDGDYGMDRVFNNLVLIYNAPWPLNICLHDRVLAKYNTIFCILTRVKYAIWALESVFHLLRNHRRATPTTKSVYFQASLWRHEMDRVVRDLDAYFCLHAVQSSWRVFIKRIGAFELLPSLDEHSQPPEELTTMRSLDELSQAHEECVDTIIHSCLMNIAEDGPGIQASLAGLLDSVHRFRRTLLLTQGQEYAASNQLNAVVDQFRSHSHSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS10</accession>
    <name>A0A0R3WS10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3535</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002602">
        <property type="protein sequence ID" value="VDM22825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS10"/>
    <dbReference type="STRING" id="6205.A0A0R3WS10"/>
    <dbReference type="WBParaSite" id="TTAC_0000355001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000355001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000355001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000355001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="62655" checksum="7D7B9F4FD4618573" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT98</accession>
    <name>A0A0R3WT98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3973</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003394">
        <property type="protein sequence ID" value="VDM23894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT98"/>
    <dbReference type="STRING" id="6205.A0A0R3WT98"/>
    <dbReference type="WBParaSite" id="TTAC_0000398801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000398801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000398801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253424at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000398801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67391" checksum="2E43E09A8BDA8EC6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTV5</accession>
    <name>A0A0R3WTV5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TLE_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003848">
        <property type="protein sequence ID" value="VDM24365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTV5"/>
    <dbReference type="WBParaSite" id="TTAC_0000419501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000419501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000419501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10605212at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000419501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13347" checksum="F0659D6B7C617950" modified="2016-01-20" version="1">SELQPSPLKNGLPVLPEALAVSERSTLPLAVPPNSTLLNTLHSGVASFSIAPAGMGTAVVESTSVGGEGQQLMHQQYYQDRIQRLERELESVRRQASRHVDVSFINAPVGVLLTQCYHDLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUE7</accession>
    <name>A0A0R3WUE7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4371</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004249">
        <property type="protein sequence ID" value="VDM24780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUE7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUE7"/>
    <dbReference type="WBParaSite" id="TTAC_0000438701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000438701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000438701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008090">
        <property type="term" value="P:retrograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF314">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="2">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="3">
        <location>
            <begin position="252"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000438701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37894" checksum="67F73FC5773C490B" modified="2016-01-20" version="1">MRNPPPAVKMALEAICLLLGEKSTDWRQILTIIVKDSFVPSILNFDTEEITDSIRETMKKKYIENPEFNYEKVNRASTACGPMVKWAIAQIGYADILKKVEPLRDELKALEDAASANEKKAEDVEATIGALEKSIAKYKDEYAVLISQAQSIKADLASVEAKVERSVALIKSLSSERTRWEAGSETFKSQMATIIGDCLLSSAFMAYAGYFDQSLRLSLVSSWAVHLNAAGIQFRPDLARVEYLSTPDERLRWQASVLPDDELSVENAIILRRFNRYPLIIDPSGQAIEFLMEEYKSKKIAKTSFLDDAFRKTLESSLRFGTPLLVQDVESYDPILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUG9</accession>
    <name>A0A0R3WUG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004302">
        <property type="protein sequence ID" value="VDM24826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000440901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000440901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000440901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000440901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15028" checksum="445ACCEB22E3128B" modified="2016-01-20" version="1">MIEETKMDREMTSTRSLSPHTLLSSHVMPTTSSGAQSRSVATLTLPLRSLCRRVMRHPNLPVSLSRHSHLSVDAALNVTKSDATDNDGGTISGGGCDVIVSDEQILAYPYGTKGSESCIHNDSGKDMFETDIDDVDEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUQ7</accession>
    <name>A0A0R3WUQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4483</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004565">
        <property type="protein sequence ID" value="VDM25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000449701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000449701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000449701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000449701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17039" checksum="67EA73FA1750732B" modified="2016-01-20" version="1">MRRFPFLCHSTPSQCFLARIYLYPSSLLLLLPYYHHNHQCHLHNRHNHRRSSKMRKRSLGLVQTADCAAVVIAVVVVPIAVPLTRDTNWQSDFWTPSSFRRQLFSRFRSGTSSSSQRTTKTVSNLRPHTSTQCNTFLFIIHVTYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUU5</accession>
    <name>A0A0R3WUU5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004653">
        <property type="protein sequence ID" value="VDM25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUU5"/>
    <dbReference type="STRING" id="6205.A0A0R3WUU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000453501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000453501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000453501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000453501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14250" checksum="17310A8E98D713FD" modified="2016-01-20" version="1">MKRSLFELLQAPSPYIIGLPRSFRDSRLSFHLPKDVLLVDLDTQELYGQDAHEPVPKLPPNEERKLTSQLNKVIEGLNGLKAVESGEGKKGKENGNELTSIADLNIFQLEDLNLDEDLLDLAIRIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUX0</accession>
    <name>A0A0R3WUX0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004723">
        <property type="protein sequence ID" value="VDM25154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000456001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000456001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000456001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276417at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000456001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7965" checksum="EFADDBB406C16F5D" modified="2016-01-20" version="1">MKEEDGPDEDEFASAGSIWRIEEPKSLANKTWVQKTLFAIRFKGRIICKAESCGMSLLVSHSPSLVEPNSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV23</accession>
    <name>A0A0R3WV23_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4596</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004853">
        <property type="protein sequence ID" value="VDM25252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV23"/>
    <dbReference type="STRING" id="6205.A0A0R3WV23"/>
    <dbReference type="WBParaSite" id="TTAC_0000461301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM25252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="654" mass="71630" checksum="876739A8B98EA819" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV39</accession>
    <name>A0A0R3WV39_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4613</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004888">
        <property type="protein sequence ID" value="VDM25287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV39"/>
    <dbReference type="WBParaSite" id="TTAC_0000462901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000462901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000462901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244464at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000462901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19867" checksum="FE655B03E4DB154E" modified="2016-01-20" version="1">MLKYPDDPLVLRPQVGGDLLRHRSSTGLCRPRSFILRLMLICVILATISGCIIIIFTLRHSNAWPWHRHTYRSMSAAGFCRALTPFPGLDVEERFLYEPNAITISHGSVADFPSVLIFHLLRDAITVMRTRGTCYVYPLTREVSDAVPVDETVFERIKVHFLFLLYISKGYDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVH0</accession>
    <name>A0A0R3WVH0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005222">
        <property type="protein sequence ID" value="VDM25569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVH0"/>
    <dbReference type="WBParaSite" id="TTAC_0000476001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000476001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000476001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000476001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10261" checksum="B059BD9B8568B073" modified="2016-01-20" version="1">MSVTTFGMWWEVEWRGDESVHQHINGVLFCSIVFGAAAKVSVHSSSSSSSTTTTTTTTTISSSSSYSYYYYFGFFDMHGGGGGGGGDDGGRKEVACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVJ4</accession>
    <name>A0A0R3WVJ4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4770</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005285">
        <property type="protein sequence ID" value="VDM25612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WVJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000478401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000478401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000478401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM25612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000478401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23350" checksum="7851A487AC2F488D" modified="2016-01-20" version="1">MVQLSRRERKEQYFKKFSTILHNYERCFVVCADNVRSTQMQQIRGALRGSAEIIFGKNTQMKKVINNQLVRDSRLEKLLPLLKENVGLVFTVRDLGEVRRALESNRLEAPAKAGTIAPCDVTVPALNTGLGPEKTSFFQALNIQTKITRGTIEILNDVPLIKKGQKVGQSEAVLLKMLKINPFDYGLQIRQVFDQGCVYGPEVLDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVU3</accession>
    <name>A0A0R3WVU3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005532">
        <property type="protein sequence ID" value="VDM25791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVU3"/>
    <dbReference type="WBParaSite" id="TTAC_0000488301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000488301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000488301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000488301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10144" checksum="55BA1E6F6859FE68" modified="2016-01-20" version="1">MAAEDCEGFGGKLGQMSQNVYYEMLLAEADLGQTSSGTMMLVAAGYLSSSFDSANMSASPWGSTSKRCSWRLCDVATPCLDELLRARDLVRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWM0</accession>
    <name>A0A0R3WWM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleos_tra2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5145</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006386">
        <property type="protein sequence ID" value="VDM26348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WWM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000516001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000516001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000516001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="3">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="2">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000516001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24587" checksum="205AD28330F5A835" modified="2016-01-20" version="1">MAEFLENSQVGSQFVFGSLQCFAFAVLPVVIFFSSFMAVCFHLGIVQLLIDKPSKIAAKVIKTTGPETLNAIANIFFSMTEAPLITRPYLAMSTNSELHAMIVNGFASIAGSVLAAFISFGVPPNHLLIACIISAPAALAVSKIIYPETKISPLANSEISLKMKSPYNSALEAAMVGAMEAVPICAGITANLIAFLSIYNFLNRILVWLGKRASLQFDLTFEVSSLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWS5</accession>
    <name>A0A0R3WWS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006561">
        <property type="protein sequence ID" value="VDM26455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000521501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000521501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000521501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000521501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="45" mass="4800" checksum="6774FACBB1E3A5A4" modified="2016-01-20" version="1">MPQRCVATAAAAVAVADIIVSVLTGIISIIIWNCKCMERARINNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX12</accession>
    <name>A0A0R3WX12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5288</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006886">
        <property type="protein sequence ID" value="VDM26623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX12"/>
    <dbReference type="STRING" id="6205.A0A0R3WX12"/>
    <dbReference type="WBParaSite" id="TTAC_0000530201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000530201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000530201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279231at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000530201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34534" checksum="0650027157B92546" modified="2016-01-20" version="1">STLKKNTAFVKKIRNLTESSKESLLKDFEGLNLSKYVAEVATAITEPKVKMTDIPFMLRLCSLMHRRYSDFSSLLFDAWKKVFSQQKTEKAPNLSKLRVDLVFFADSITTGVLPENDSVRLLALQLTQLTNGDKNFVNIGIVSSFVKACGDDWAGLIPRKYTSLAKTYGVTIHRSAFLPKERKTKCRGLFHDYYTAALERLTSMAKEARRVIASNRHQMFTKGEVHPERHEKEEQLVAACKKFYEAVSVLADVVDKDAPPAVATLLAVEEDENNGLKAEGQLQASEVRLFVVNNHLGFSLDTFFSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX78</accession>
    <name>A0A0R3WX78_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exo70 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5353</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007157">
        <property type="protein sequence ID" value="VDM26779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX78"/>
    <dbReference type="STRING" id="6205.A0A0R3WX78"/>
    <dbReference type="WBParaSite" id="TTAC_0000536801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000536801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000536801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000536801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10114" checksum="95E188E23C4A8C04" modified="2016-01-20" version="1">MGINQGLASLIKQHSQLSIPDKELREDLRECLSRELVKLYQAFYDRSLQTPFTSRREKYIKLSPSEFQAKLDQMFLPPAAQIVQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXA3</accession>
    <name>A0A0R3WXA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5378</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007235">
        <property type="protein sequence ID" value="VDM26838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000539301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000539301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000539301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133088" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000539301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7982" checksum="3F108BF1FB5F6B2F" modified="2016-01-20" version="1">MRALAGAIVTGATLLTFLNLRDSHEGEIEQGCVCQLTTTTRALLLPCFSQPVFCEMTAKESERWGAPQAVRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXV9</accession>
    <name>A0A0R3WXV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008101">
        <property type="protein sequence ID" value="VDM27274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXV9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000559901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000559901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000559901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6236179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000559901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13600" checksum="D7CDE7C8A76CAB4B" modified="2016-01-20" version="1">MSLETVHQEFEQIDTNHYGFITRADLEAYARRTHQNDDFVEKWFQWFEGEHKGIITMDDVCTTLGIPMREEYRQKVDKKRQMISQGLISAPPEASLVFAAPPVSSSTTSAQKSSMEGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY39</accession>
    <name>A0A0R3WY39_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5663</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008487">
        <property type="protein sequence ID" value="VDM27411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY39"/>
    <dbReference type="WBParaSite" id="TTAC_0000567901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000567901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000567901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000567901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8822" checksum="CB39DFC258943B8A" modified="2016-01-20" version="1">MQRVMRLRLLVAAVVHYTPRSSIAYESGLVALASLEKVLLPLLSKRCASFLAYLLHFLICHLYVQFPTNGSDELLSAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZQ1</accession>
    <name>A0A0R3WZQ1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS6274</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000628901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000628901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000628901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="14">
        <location>
            <begin position="435"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000628901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="730" mass="82397" checksum="08A83670CCE21B9E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0A1</accession>
    <name>A0A0R3X0A1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SKIP_SNW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6525</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0A1"/>
    <dbReference type="STRING" id="6205.A0A0R3X0A1"/>
    <dbReference type="WBParaSite" id="TTAC_0000654001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000654001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000654001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="168"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000654001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60702" checksum="E9D48068CF35160D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0B0</accession>
    <name>A0A0R3X0B0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6535</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0B0"/>
    <dbReference type="STRING" id="6205.A0A0R3X0B0"/>
    <dbReference type="WBParaSite" id="TTAC_0000655001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000655001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000655001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331765at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039986">
        <property type="entry name" value="CFAP210"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="4">
        <location>
            <begin position="58"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000655001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="53563" checksum="3503F3C8FAAB84C7" modified="2016-01-20" version="1">MHAGYFKGARKKKLHEREERLTKEEEERVAVDLEWAKEQAKDRLRRLCIARSTQLYDTSRLKKFHAALRLGNALRENDLQLKLKEQKRKAESKEREIEYQAMLDRIKEAEEKEKKTMEENRAAERLIHEFQRSQIEERRQREEGEKLVLKEEGERLRSLAKEAERMKLQMQEERLKQQKLTTRDLLEEIEDRKKLRLVERIRDEEEDEKNLIYAVAKRQMCLTQMNREGVAAAEKASRQKELAQNLSTLISQRQVARDVPMEISAKQEEERWHQRIEAEARKREEAKECMRKQREDALKAREERMAHQMEEGRAELQHNISLDEAAQREDEERRAKRLQEGKALAHLYLEEMQRHEEARRKEREADNWLEKFNAQSNMKEDLFQNYANRVIKTCEETGIPTFALKKAAHPSTATDELALTVANDFGVDGDETNEKCALLPDLPPHQENLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0H2</accession>
    <name>A0A0R3X0H2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6615</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0H2"/>
    <dbReference type="STRING" id="6205.A0A0R3X0H2"/>
    <dbReference type="WBParaSite" id="TTAC_0000663001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000663001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000663001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000663001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12457" checksum="49A3A1E21550DDD7" modified="2016-01-20" version="1">MVNVPKTRRTFCKSSKCKKHTLHKVSQYKAGKAGLYTQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECTECKYKQQLRIKRCKHFELGGDKKKKGQMIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X199</accession>
    <name>A0A0R3X199_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6947</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X199"/>
    <dbReference type="STRING" id="6205.A0A0R3X199"/>
    <dbReference type="WBParaSite" id="TTAC_0000696201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000696201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000696201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000696201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53672" checksum="5E60B895444FF640" modified="2016-01-20" version="1">MFPSESSPPRASTSRADTPSEDLNPTLKDTAIFTTELTVLATLFLHDKYPNARAVLPVCLRFDVCERINGDFTIQNCRFNLLYYILYLIESLRFDTKRLTTQLIITRIVVLEDVCSTDPTDSYFAPQNDFYTNPGTSTPLGSGITDNVVLQLAPFPALSLELLHSRDFFSCTGPLLIVVQGCNESTLGVWEPTHLMKEGNEPFSRNLKTGSQIEFVKLAHSRGYQVAFLNLNCLAAETSIPDRYSERVQACHLNCDVFPSHGASQSDAGPSDRFSALFYLQQSPALICDVQRFFFPPLPETQQSVVSLGERMACGWEALMARCRSSNIVVWVHRRAEESFFYPLCPTPQTRTRQPWLLRPTLGNSEDGDGSTQEPISMPHSLGSQPSSSGTSSLHCTDTHRRKLIATWADRAKSYWLSLQSRVKAVVFVDPCQMFTSFPQSGVGWGLLDPNATAATLSLQQQDIDRLREWFAQARLPNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1F7</accession>
    <name>A0A0R3X1F7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase POLQ-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7017</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1F7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1F7"/>
    <dbReference type="WBParaSite" id="TTAC_0000703201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000703201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000703201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="375"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000703201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110009" checksum="5BDAAE639EA90D74" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X278</accession>
    <name>A0A0R3X278_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7359</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020365">
        <property type="protein sequence ID" value="VDM31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X278"/>
    <dbReference type="STRING" id="6205.A0A0R3X278"/>
    <dbReference type="WBParaSite" id="TTAC_0000737401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000737401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000737401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10047020at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000737401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="748" mass="85359" checksum="B4C35FBB1D2D846A" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Q3</accession>
    <name>A0A0R3X2Q3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7572</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020384">
        <property type="protein sequence ID" value="VDM31974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Q3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Q3"/>
    <dbReference type="WBParaSite" id="TTAC_0000758701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000758701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000758701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="232"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000758701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51305" checksum="E35CCCDC1C9BDA26" modified="2016-01-20" version="1">MAIEKVDHDFAAAVDEQIPTFKCLAKCGKIDEALEKCYALEKQTRTASDAISTGRLLVCIVEMLGDHEQWQKLNEHLVIMSKKRNQLKQAVAKMVQVAMKYVGSIADEQVKLNLIATLRTVTEGKIYVEVERARLTRMLAQIKESNGFVNEAADVLQEVKVETFGSMDKREKVEFILEQMRLCLANKDYSRTQILSRKISPKFFQEEGTEDLKLKFYKQMIEVDIQHDAYLSISKHFWEIYNTKLVQENPADKRSALCNIVVYLILSPYDNEHNDLMHRRMKLRDLEALPEYLDMLKAFTTQELLSWKSFRERHEKTLRCETLAFSSSDDHQRPEKSFKSLQERVTEHNIRVISAYYTQIRLARLAELLHLDVEEAEECLCKLVVNKTVQAKIDRLDTVVRFTESKLATDVLNDWSHNATSLMSLINEATHLINKERMVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2W0</accession>
    <name>A0A0R3X2W0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7636</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020389">
        <property type="protein sequence ID" value="VDM32051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2W0"/>
    <dbReference type="STRING" id="6205.A0A0R3X2W0"/>
    <dbReference type="WBParaSite" id="TTAC_0000765101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000765101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000765101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="152"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000765101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36427" checksum="77DC043C896FE7E7" modified="2016-01-20" version="1">MILPRSRLRDARGRIPIYCKPVYQRPKGSAQPKSSSIGRPSVFLGCGTRTFKQTFIQCGLFTFVSINTIFVGSMIWSYENWRARISKHRDGFKKTLRDFFTTIVGRPPKPSDIFWAIALANFIIFICNNSRHYGPTFLRYFANSPYGPWPAMSMFLSIFSHQMFFHMFLNMYVLNNFTQPLVRVLGMEQYFAVFLSGGIFASFLSALAKVARGSRVPSIGASGAVCAVLGAFCMLEPHAMLCLPLVVNVIPHAFSAGSACWVIVAFEACGATFLARRSPIDHAAHLGGLLFGMYYGLEGKKVVLKHRDEVIKVWRTLKGESGKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X350</accession>
    <name>A0A0R3X350_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7735</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020399">
        <property type="protein sequence ID" value="VDM32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X350"/>
    <dbReference type="STRING" id="6205.A0A0R3X350"/>
    <dbReference type="WBParaSite" id="TTAC_0000775001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000775001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000775001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="8">
        <location>
            <begin position="57"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000775001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="657" mass="77364" checksum="B92B2CD1C7ED2F92" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B0</accession>
    <name>A0A0R3X4B0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8221</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020467">
        <property type="protein sequence ID" value="VDM32737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4B0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4B0"/>
    <dbReference type="WBParaSite" id="TTAC_0000823601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000823601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000823601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000823601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52317" checksum="5AA4D3D001D3590A" modified="2016-06-08" version="2">MYRRSRLVGLLLALMFCVFAFLTLLHTVCFANEKNVLVHVHTLFRHGDRTSVTPYLFDGYDPFKVWPDGLGQLTQEGIEQLFLLGKWLRNKYSSFIDRNYNVSTFRMRSSDLDRSLMSAEAMMAGFFHRSNSSLSKYGLHWRPIPTHTVPTTTDTLLSFQPCPRMAQRREELLQSKEGIDLFKQHKKTIDHVGTSYGIKNITLIDIWGIADDLFCLRSHNASLPKWCTQDVFQELDTITNKLFRLLYTDQEILKLAVGVFLKDTFDRMDEYIHKNTSEFSSLESFLAYSAHDTNVAPLLNALGAYADWDRPQYAALIAMELLAPRTDALPNGGHLLRLYYKRGWKDETGSYVPFNACRDREAKEGCAFALVRESIASLLLSTEEIEEACKAEWLPSRYRLIVAITLSTFLAILFFTLGAVHCVVWRQRCWQRNQRGNNFGGASQLPYSPLVSSPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4M5</accession>
    <name>A0A0R3X4M5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II toxin-antitoxin system RelE/ParE family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8357</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020489">
        <property type="protein sequence ID" value="VDM32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4M5"/>
    <dbReference type="WBParaSite" id="TTAC_0000837201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000837201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000837201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262466at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000837201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9556" checksum="1864161560339503" modified="2016-01-20" version="1">MGNLRSRLDDKAEIKRKYELVLKIYEEDRVNTIRDATTRYKAAGRAALASWLDYMTEPRPDPADLLRSVGFNPEVLGLESQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5X7</accession>
    <name>A0A0R3X5X7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibrillar collagen NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8878</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020615">
        <property type="protein sequence ID" value="VDM33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5X7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5X7"/>
    <dbReference type="WBParaSite" id="TTAC_0000889301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000889301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000889301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260245at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000889301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23233" checksum="FEBCF23E88571CD7" modified="2016-01-20" version="1">MICVTSEFYIDPNGGHWRDSFPVHCQPGTLATVIPSLLKHPEPIGILNSRDNHDFFWYASEALKSEEAELPYQITKDQLAHLQLSSETASQKLVIGCRYYDPKDKVIFLGDGNQALSINATDSALVVIDILENSCSSSNYMGQMVVQIRTQMTTMLPIRDVRLLTPTSNEAKVSVEPGPVVFSGAVEEAPIGIDQLYATDVSRYHAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X634</accession>
    <name>A0A0R3X634_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 207</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8938</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020631">
        <property type="protein sequence ID" value="VDM33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X634"/>
    <dbReference type="STRING" id="6205.A0A0R3X634"/>
    <dbReference type="WBParaSite" id="TTAC_0000895301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000895301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000895301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000895301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35222" checksum="393BB511A618AE29" modified="2016-06-08" version="2">MGRKKRKQIKPWCWYCNRDFEDEKILIHHQKAKHFKCPFCHRKLFTGPGLSIHCNAVHKEKLDKIPNALAHRASTVIDIYGMSGIPEADLLEHERQKLGQEGEDEPPEKVERVDDTASSSFVPPLPPFPFMPPVPSVMPYMPVVPGGVQPFLSGVVPAPPPPPPPPPPPPPTSEAVSTTNDVSSPKPTFPAYSEAEIVKASASKIIRPVSGLNGVTVELVYPEEDLSLEELMAAKPKYQEMLKRALQPPPPPPSLTAMPAPILPTTTPGMLSPYVPLPRGAPVSTTGVPFMPMQQPMYGMPGYPQSVGQVPPAWMGLPNVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X658</accession>
    <name>A0A0R3X658_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8964</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020639">
        <property type="protein sequence ID" value="VDM33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X658"/>
    <dbReference type="WBParaSite" id="TTAC_0000897901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000897901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000897901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000897901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10847" checksum="9725D6A9451FC343" modified="2016-01-20" version="1">MANAAVGELMLDDLPPDTYEVMTEAIEKNETTFYNLIYLTAWRKVQREFLAFITPPCIAAEESVSHSPTGEEGNSGSALHSAVLSLLVLCMAVTLVQTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6D2</accession>
    <name>A0A0R3X6D2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9044</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020663">
        <property type="protein sequence ID" value="VDM33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6D2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6D2"/>
    <dbReference type="WBParaSite" id="TTAC_0000905901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000905901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000905901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000905901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="587" mass="65908" checksum="E3DA5E34188CC656" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6L1</accession>
    <name>A0A0R3X6L1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nipped-B protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9134</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020689">
        <property type="protein sequence ID" value="VDM33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X6L1"/>
    <dbReference type="WBParaSite" id="TTAC_0000914901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000914901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000914901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="1925"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
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            <end position="503"/>
        </location>
    </feature>
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        <location>
            <begin position="1163"/>
            <end position="1191"/>
        </location>
    </feature>
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            <end position="1318"/>
        </location>
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        <location>
            <begin position="2394"/>
            <end position="2537"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
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        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
            <begin position="2470"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="2526"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM33859.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000914901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2592" mass="285905" checksum="4ACD935CADC93C12" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">EOG090X0AI9</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TTAC_LOCUS9260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000927501-mRNA-1"/>
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</entry>
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        <submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS9482</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="1"/>
            <end position="25"/>
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    </feature>
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        <location>
            <begin position="26"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="VDM34288.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000949701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47614" checksum="A19E6E4DE1E0142B" modified="2016-01-20" version="1">MCEPTTSLLLLFILCKSLSFGEIQANDYKCVSKLNFTDVDVVIYIGCRIPSHGPPELKDLIEDLNDIHSIYPQFDDTLNVYTPRYTPQRVRRVIFAPTRGISDTIDGTLDVYDSATKAATLAYLGAFKSSESVLVVIGSDVANSQAPWRAKNMIELNIALGSLYPLYQPKNRTKKYEQFAIFNASREVMKFSEAVENGRRIARHITSEQGVVWSYANLLQLLQSTFQDNVIHLNISDFWRANSSTGPSLEGKIFHMKYRPVDAKSAVVLITSCSIRRGIATIAGFFETIRWLQPKATEFQAVIGCFEGNLDPLSDLHGNSLNEVFGIQMPNGNADVYVIGAEKGVLERRNSYYYGQQLDYEFGPLMDDNRVANFIKQSIRKKAAKNIFFLEKDGEGDSASPLYSTPIAGLVNRYLLKQFKQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Y4</accession>
    <name>A0A0R3X9Y4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arm_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0001036101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260699at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006911">
        <property type="entry name" value="ARM-rpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04826">
        <property type="entry name" value="Arm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Armadillo repeat-containing" evidence="1">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001036101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11573" checksum="E6658D957B159317" modified="2016-01-20" version="1">MNELVALVRLLGNFSMMDDACVTVGQHLSEVLELITSESDVVKRQVWTVLLNLSCNKQCLDVILRAESVKEDLVSSTTLFLQDGLDKEAFADAWLLLQMLKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAE1</accession>
    <name>A0A0R3XAE1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Period circadian protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10501</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021774">
        <property type="protein sequence ID" value="VDM35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAE1"/>
    <dbReference type="STRING" id="6205.A0A0R3XAE1"/>
    <dbReference type="WBParaSite" id="TTAC_0001051801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001051801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001051801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001051801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="14679" checksum="35FB79A784F77FB8" modified="2016-01-20" version="1">QNEEAKSDSELLNGANHINHNVKRDVVVNGTAAALGHSPRENGGGSTSCSNDTKLERNRASTPNTSSIANSNGDNRSPVSPSALNLGTPISSTHNTSMTSAASPKPSTSINPQLPVTSTPIGEFALFSFNSSLGAVATHLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBA1</accession>
    <name>A0A0R3XBA1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10811</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022286">
        <property type="protein sequence ID" value="VDM35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBA1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBA1"/>
    <dbReference type="WBParaSite" id="TTAC_0001082801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001082801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001082801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="82"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001082801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16957" checksum="995A9999BA6104E3" modified="2016-01-20" version="1">MGDEEFSVGDAGASMGTPIQCGAIKKNAYVIIKEKPCKIVEVSASKTGKHGSAKINYVGIDIFSGKRLEECRPSGHTVISPTVTRTECQLVSIDPDGFLELLMADNTTRSDIHGSDMLDTLKEKFENLGDNEDLLVTYISAMGQEKVVECRINTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBP8</accession>
    <name>A0A0R3XBP8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10958</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022606">
        <property type="protein sequence ID" value="VDM35938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001097501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001097501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001097501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001097501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19356" checksum="B90CBAB87B260EEF" modified="2016-01-20" version="1">MLVHTALASVANHFVNSVGEHKEAVGGKRKEAVKCRPANRQVSPPAVDRWLPKCGNPPNTWHYAMLRLASIQEHWIALVCRRLTKPCLNKSRASDRRGTECQTRKCKEFSDSEGNQSPTRTALKPILTALPIVSQXXXXRGPLLSNTLPISTSTSHHTQLTPTLLPTLTHAGSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBZ8</accession>
    <name>A0A0R3XBZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11058</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022832">
        <property type="protein sequence ID" value="VDM36038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0001107501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001107501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001107501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001107501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36931" checksum="FF97C880D9D45897" modified="2016-01-20" version="1">MEHGGEGVGISDSPQTQIMVTSRRVSTVRTFACCGPGKKRYLISVLCMACLTIVIGMRPSHHRQLPWTATITEDLVENAVFFAYLIASPIGGYLTVRHDSSLLLGCSVAMTCGLNLFLPLAETIGSNIDAKLALIIILRLLQGMAEGCLIPAVFGTLRYWSPDSERSTLISLAVIGVSLGPLIGLPVCAEIEQKWGWGVVFYIYANLGLIWCIFWWRMVDEKPQKDRSLSKAEKIYLKENTSQQLLFDPAHVKIPWVAIFTSKPIMAIFLTYAADDWTFQISSVCMQTFYQQRYNADVQKTIFLLSFPFLSRSIFVPIGKLMGNFAIQIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC22</accession>
    <name>A0A0R3XC22_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11082</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022902">
        <property type="protein sequence ID" value="VDM36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC22"/>
    <dbReference type="STRING" id="6205.A0A0R3XC22"/>
    <dbReference type="WBParaSite" id="TTAC_0001109901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001109901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001109901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001109901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32909" checksum="65209E04A1550BEF" modified="2016-01-20" version="1">MADEDTAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQVSWVVSVSSPQHDRIEWSVLSLYASGRTTGVVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDHLVKIMTERGYNFTTTAEREIARDIKEKLCYVALDFEQEMMTSTSSAILERSYELPDGQLITIGNERFRCPEALFQPGFLGLEATGIHETTYNSIMKCDVDIRKDLYSNTVLSGGSTMFQGIAERMQREISSLAPTTVKIRIAAPPERKYSVWIGGSILASLSTFQQMWISKMEYEEIGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCD7</accession>
    <name>A0A0R3XCD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11196</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023181">
        <property type="protein sequence ID" value="VDM36176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCD7"/>
    <dbReference type="STRING" id="6205.A0A0R3XCD7"/>
    <dbReference type="WBParaSite" id="TTAC_0001121401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001121401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001121401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001121401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30138" checksum="6CB929ED21A4855D" modified="2016-01-20" version="1">MDYYENFDAEQIPVYVTAVSFIGLGKTNLDFLKNQLRPLVKSKNMRELLNNSSDLKSMLLGLQIFKHCEVSIDTEKQSSCSDAYKVNIFVEEKKPQNLKAQWTVNTDGSMRVGGYYALNNIFRKGERLEVEGNIGRDSSKMRFATFTKPFERNPNIKFSLGGSDCSYDHWWSKILRNESSIFAEIGALSRWGIQKLHWSSVWREIEASKSGANLKTNLRHSLEVDSRDDRILPQSGLLLRLSEELSFLYPPPPRTAVGFETAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCR0</accession>
    <name>A0A0R3XCR0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11320</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023630">
        <property type="protein sequence ID" value="VDM36300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XCR0"/>
    <dbReference type="WBParaSite" id="TTAC_0001133701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001133701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001133701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260642at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001133701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42500" checksum="1318F94119443FED" modified="2016-01-20" version="1">MLHTLESNLPVCSYDCATYQQFLANFCVLTTVSLTEELNSSTPARLPTPTDLLSRRAHRAMTEFARQSRAIRTLPQRLRAKHWKVVNSPSTASTSVSTNSPPVSAPAGRSLTPVPIRKVADIDRTPRLDRTRSLTQEELPVMVEEEEVVETRKKSPQLRQPPRSTLQRQHMEWRRAMLEVAEDGSGDSGGGGGGEQKSSIHGDLYDTLFTLQTLNGKSEVEELLARVRSVYEARSAMGKSALASQAVGGNATGSHDPXXXVYEARSAMGKSALASQAVGGNTTGSHDLKAGKGGFYILEHNRQRLNNIMATTGAMQMVHSSKMVTTVAATHRKKCCTTPDPLNSRMLQRFTIPLFHTMDNEQKRRPFSTLSRFQRSSASETEDGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD11</accession>
    <name>A0A0R3XD11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tobamovirus multiplication protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11421</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024106">
        <property type="protein sequence ID" value="VDM36432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD11"/>
    <dbReference type="WBParaSite" id="TTAC_0001143801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001143801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001143801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10557331at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001143801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27133" checksum="051F7F058644DC56" modified="2016-01-20" version="1">MPHLKVCKRTWKRSEDEFVISSIVQALIRVILVVIAGALLLSNQQLQTVCPAEFKGILITSAVICILHILLFIVIAAVSGRGGVMEVQKRKPLGPLIIVHFLLMILELIFYCLSIWQVVVFRNDHSYVDLHSAFVAVICWCSVLMFTIVCEIVDWIRHYDKDGRLKYEFYNTFLYDGVDKKTEDEKRELVMNMRMVEKFKWQNVLSKKFDSPEDYGSDDKEAALHAVSTAFVDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD68</accession>
    <name>A0A0R3XD68_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GatB_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11479</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024376">
        <property type="protein sequence ID" value="VDM36618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD68"/>
    <dbReference type="STRING" id="6205.A0A0R3XD68"/>
    <dbReference type="WBParaSite" id="TTAC_0001149501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001149501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001149501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic" evidence="5">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001149501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31319" checksum="10FC6ABA32F97259" modified="2016-01-20" version="1">MLRLLSPLHRILKSYSTARPECVPIIGLEVHAQLTSARSKLFSPAHYSFAAPPNSQVAPLDAALPGSMPVLNRDCVVWAIVAALALNCRINLLSRFDRKHYFYFDSPAGYQITQHAQPIAEDGWLEYIWKPPDIKSPPQVSKAKIRRIQLEQDTGKSLRDQKTGRSLIDLNRAGVALIEIVTDPDFNTSYQAAAFVNELSTLLHHLRVCSANMSTGELRVDINVSVGISSSQQGSVVEVKNVNSLRAIRYAIDYEIFRQCRIFRSGGAIINETRCFDPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDJ8</accession>
    <name>A0A158RDJ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS759</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000091">
        <property type="protein sequence ID" value="VDM16949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDJ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000075801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000075801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000075801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="774"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="9">
        <location>
            <begin position="1151"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="9">
        <location>
            <begin position="1304"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="8">
        <location>
            <begin position="1676"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1856"/>
            <end position="1875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000075801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2239" mass="244250" checksum="96D49B5F878C42C3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDP4</accession>
    <name>A0A158RDP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1180</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000204">
        <property type="protein sequence ID" value="VDM17586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDP4"/>
    <dbReference type="STRING" id="6205.A0A158RDP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000117901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000117901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000117901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256043at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF7">
        <property type="entry name" value="C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="5">
        <location>
            <begin position="371"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000117901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116862" checksum="0F68B9BEEF35A025" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE79</accession>
    <name>A0A158RE79_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6797</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020323">
        <property type="protein sequence ID" value="VDM31066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE79"/>
    <dbReference type="STRING" id="6205.A0A158RE79"/>
    <dbReference type="WBParaSite" id="TTAC_0000681201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000681201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000681201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043136014" description="non-specific protein-tyrosine kinase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="111"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000681201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48147" checksum="626B0648B84BA48D" modified="2016-06-08" version="1">MRWLRFQLNVFCLEVINLAASMLDVTTLCQAWNFLVFEMFVSAHFRLQHFDFVRTADLHRIGLSAPAIGRIKEAIKIHRENAGLPRNPRKKHHYGLSFGIPLLDLDVNLHKENNGHLGSGSFGVVRRGDWKTPTGKTIPVALKILRHDAANFFSTVLSEVMLMQSVSHPNLVRIYGIIPLNPLVIVTELAPLGSLLTALRAHSRHVLWDIGIQLARGMAHLAACHLIHRDLAARNVLLFSAPSDVVVKIGDFGLLRRVPGCVYVGIGKQKIPFAWSPPEAICGRCFSQASDVWSWGVTVWEVWTGGAEPWPGLSSDAVLAELKAAHRLTWPRTTCPRRLYQLLLAAWRYDPAHRPSFEYLVGRLDKVCSVICNFCTNGMLFTTNFWTLVNDICHNCTTMVAFCLYFSFRLHLDSLRFDNVIARPPVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REH7</accession>
    <name>A0A158REH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7298</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020360">
        <property type="protein sequence ID" value="VDM31658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000731301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000731301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000731301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000731301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1308" mass="141137" checksum="42AD0837E4729CA3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E8D0</accession>
    <name>A0A3P7E8D0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000769">
        <property type="protein sequence ID" value="VDM18960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E8D0"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF3">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15684" checksum="2C56C8D175DD4083" modified="2019-02-13" version="1">MGRIDAGSILPQALSDPDPQFDTILPRIRRLFYEAGGDSMAVDAFQLDSILNTLLKEDHRLPYTMVSTDACRALIAMRNDRYTGRLIESEFQPMWSLLRCWSRMFAAFDPQRAGYITCLDFRILIEQVGRLHHRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EAR6</accession>
    <name>A0A3P7EAR6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000454">
        <property type="protein sequence ID" value="VDM18413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EAR6"/>
    <dbReference type="OrthoDB" id="302453at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="508"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="784" mass="87007" checksum="ED93CABCDE6054A4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EFG8</accession>
    <name>A0A3P7EFG8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="3">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000433">
        <property type="protein sequence ID" value="VDM18356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EFG8"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="209" mass="23853" checksum="CAE6D0FD93DC7ABB" modified="2019-02-13" version="1">MVFLENYRVSLAEKIFPAADLSQQISTAGTEASGTGNMKFMVNGALTLGTLDGANIEMSEECGKENMFIFGMTVHEVEELSRKGYDSQKYINACPELKLILSQIEQGYFSPEEPDLFKDIYKTMMFGDRFMLCADFADYMRAQAEVDKAYRNEKRWAQMMLANIAGSWKFSSDRTIREYARDIWGVEPREEKMPAPFENPEDPTASFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EIZ2</accession>
    <name>A0A3P7EIZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000041">
        <property type="protein sequence ID" value="VDM16484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EIZ2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018218143" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="108" mass="12303" checksum="B5E58EA35E13EEB2" modified="2019-02-13" version="1">MCINGCKVIIRVVYLFLIDVLHPLQFAKLINDAESHDVKTERLNLSLEYLAAYLDDILVLEQKWSKMKRLPGMDAKRITDPEPNELPLLLNHPPGMALTEVGTNYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ES21</accession>
    <name>A0A3P7ES21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005941">
        <property type="protein sequence ID" value="VDM26061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ES21"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="29" mass="3009" checksum="C2485020085A1A4E" modified="2019-02-13" version="1">MDLGTAEEASRCPVLVLIVGSAAKYWGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ES47</accession>
    <name>A0A3P7ES47_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003560">
        <property type="protein sequence ID" value="VDM24063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ES47"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="329" mass="36745" checksum="B958C629013EA60B" modified="2019-02-13" version="1">MVTDLILRNPQQRVLFYYHAKAVSDESKLCLDLALSGVGQSSLASGCSSTYEPYNLPAYLHGAVRLSSTTLVDSLYRLGGLQFLLPLFDLISNSQRDVDKTKVPPHAMEEFNMAVMEFREALGKMESSSTLEVQSPPVSKQLGTLQNVDTMMDETPEQTVLNASTEVFRLATTLLKTSASFASLNIPADTRVRLVFLHPSVVLAMGHLINSIDPLQLDANAVTNFHSMVDLCANSVLTDLNSRVEASGDFVSSSQQVEERRTARETFRVRWTFLIKQLFVDWALWSRCSPVATLQHVRHLLKRAKTIRSIYRGHLPIFRLLTAAGFYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EU62</accession>
    <name>A0A3P7EU62_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001036">
        <property type="protein sequence ID" value="VDM19907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EU62"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF2">
        <property type="entry name" value="PROTEIN RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25812" checksum="28CA5740C7B6E9E0" modified="2019-02-13" version="1">MTWASGVPYFSPLFFDPRRRREVWRFFTYFLIHQGIWHVVFNSFVTLLLGNLMEWAHGTWRVAVLYFLGVLAGSLATSVWDPQTIGVGAGGGTYALLGAHLALSVVHWEELKHDFFAVVRATTAAKRAIAIGVSGILRICLILLLCAVDFGIALYERYGLADIPLHASYSPLPAGLMTGVLVGVPLLRYLRDRPWQRIEFWASFGVCLALFTFIIFWNIFWPGYPTQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F1F8</accession>
    <name>A0A3P7F1F8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006087">
        <property type="protein sequence ID" value="VDM26156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F1F8"/>
    <dbReference type="OrthoDB" id="10003345at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="152" mass="17058" checksum="65BE74711328BD6B" modified="2019-02-13" version="1">MLKGRPGNSFLLRISDSFLGYIVSHIASSGACTHIFLHLLKPLKTSVEDIGDWKAEEMQNGSSDGDPRFYHLQGHRKFFPSLTELVKFYKDHSIVDETRDKEDGLYLQHPVGQSHLPVTSTSPSSAVSSNPPFADYFTSLFHRNDEDAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F5G2</accession>
    <name>A0A3P7F5G2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009046">
        <property type="protein sequence ID" value="VDM27666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F5G2"/>
    <dbReference type="OrthoDB" id="6236466at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="251" mass="27678" checksum="534C1CF53676F97F" modified="2019-02-13" version="1">MVYARAHFECVRYGWSESNTTSRPVVSKRIGCKAYVVIQTYKGWVEIFHLNMQHNHEINQEDAGHSTRQSRRIQTNKQAATTTTTDSGSSGNYTYFGAPTKGIGSSTECMQQNVLRRLQGPTAKPEESLKEEDYFASKGNTERVVVTTQSTERAQTMTAEEAKLALLDSQLEAVRNLAITEYGLVGTNGACSEVALAMCEELKQMEAAWIRCLAETEAQQEAAPILLEFASASATDPITTTATVKLHARQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F6C3</accession>
    <name>A0A3P7F6C3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003598">
        <property type="protein sequence ID" value="VDM24107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F6C3"/>
    <dbReference type="OrthoDB" id="10259057at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="68" mass="7898" checksum="E971506B38973EDB" modified="2019-02-13" version="1">MPKRELSNQNIRLDVLSIEKTKRTLLIGFITFPLTILAQTESEWRPIRVARDLQLDDGSSVSFRRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FHL8</accession>
    <name>A0A3P7FHL8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020561">
        <property type="protein sequence ID" value="VDM33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FHL8"/>
    <dbReference type="OrthoDB" id="6277993at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF249">
        <property type="entry name" value="TWO PORE POTASSIUM CHANNEL PROTEIN SUP-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="150" mass="17364" checksum="292AC0F6028536B5" modified="2019-02-13" version="1">MYALRKNRSTRARAFHLIIVVILVFTLILLLPAYIFMRLEPNWSYLDSIYFCFISLTTIGFGDFVPGRGPIHVSISNSTQVHKVAHELYNIGVVVYLIGGTTMLMLLVRVYREMMETERRIKRDRVILKLQHSLTEPNLLHSNTPFCIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G331</accession>
    <name>A0A3P7G331_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000128">
        <property type="protein sequence ID" value="VDM17168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G331"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="1">
        <location>
            <begin position="45"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="165" mass="18122" checksum="A760E2FDD3D92D4D" modified="2019-02-13" version="1">MGVCSCSFVERIALKVVGRPGDDVIFPLSTSSIGSQFNVSYVYTKLVPTQPVSACSRISNANDVQNGIAFVIRGFVTKASFAQAAGAVAFISYDYQNNSARILNMLPDESSTKVWIPCAFMQGSHAQHLLELMELDNKTYLDVDFPVDRTGALIILDKYSPMRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GI14</accession>
    <name>A0A3P7GI14_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSN12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001966">
        <property type="protein sequence ID" value="VDM22012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GI14"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="171"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="356" mass="40432" checksum="432252458A6FD55E" modified="2019-02-13" version="1">MQTPWDEIFSAHLRCLWAIGSNNDEEACACQLVLVKYPLSEPDLFVLTSVLWLGFSLIWNHSVDQIVVAAVDLRRFAHALDALSNKKVDDADSAYGSHLERVAQAIMKLFQICAADSLTAIEDSKKRGMMGLANQLFKIYFQINKLNLCKPIIRAIENVNIDAHFSIAQRVTYNYYVGRKAMFDGDLKMANTCLTFAFERCLASNKANKRLILIYLIPVRMLLGILPYNALLQKYKLEEFEGISNAVKIGNLRKLNEELERNEAFFISCGIYLILEKLKMITYRNLFKRIAGILKTHLLPVPAFTETLKKMGVEDIDADETECILANLVFEGKIKGYLAHQQQKLVVSKIQPFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GV42</accession>
    <name>A0A3P7GV42_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005484">
        <property type="protein sequence ID" value="VDM25762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GV42"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="187" mass="19802" checksum="BC3DD8ED7A83A7D2" modified="2019-02-13" version="1">MGILRHSLVPTEETARTRTNRVWVDALPLVATGMGAVMPSPTSAPYAFHATQFCIGDRVLGVVRKKTGDIFYLDIGCPAPASLNALAFEDLEVELTCVDEAGKAAGMGILGRHEPGSVGNAGGMSGGVMLSCSLELSRRLIDTKKFPLLAKLGEVGDRSVNPIVYNSIFYTLQHALLSPCAALMALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HG07</accession>
    <name>A0A3P7HG07_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020740">
        <property type="protein sequence ID" value="VDM34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HG07"/>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19648" checksum="8DA8D68FED2580B0" modified="2019-02-13" version="1">MGYRRPDEHKKSLNREFHQRFPNVQLTLTKMRSLKLNLLSIALRMNLDLWIVAHAYVLFEKMVLKLFVCKSNRKLCAGAALLISAKLNDLKGPALPVFIQEIESELRISHRDLLRMEMAVFIGLEFCVLPSPAETQPHFAQIQKSLGVVSVPRRPSNASHSLEDDHVFTSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HNV3</accession>
    <name>A0A3P7HNV3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TRAF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS11362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01023779">
        <property type="protein sequence ID" value="VDM36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HNV3"/>
    <dbReference type="OrthoDB" id="5574452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF151">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR (TRAF) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="27021" checksum="77529FD4DA46EB06" modified="2019-02-13" version="1">MEQHLTSDCPRRPVVCQFCQEKIEMHNQPAHVEVCKRFLIPCPNGCKRKEIPREELTAHLECDCPLQVISCPFSEQGCQFRGKKRQIRAHLDNELMLHILLLRDAVQAFHNLLDLQMQAVRDSQAAVKKMQLKLQRCETFFEPSFVWKIDGYREKFEEAQQGRKTTLFSNPFYSHRHGYRVCLSICPNGEQRHRGKYLAVFICICRGEYDALLSWPFSHPVRALPLHMPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHX3</accession>
    <name>A0A0R3WHX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS163</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHX3"/>
    <dbReference type="STRING" id="6205.A0A0R3WHX3"/>
    <dbReference type="WBParaSite" id="TTAC_0000016201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000016201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000016201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000016201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15918" checksum="1C93452BAA38C619" modified="2016-01-20" version="1">MSQAVTVPRIFYLMDELEAGQKGSNDGTISWGLENNDDNTLTTWNGMIIGPARTPFQNRMYNLQIVCGNDYPDKPPEVRFITRINMDGVGGNGQIDNSKVPSLRTWRRGMLIRNILFDLRTMMTQRENANLTQPPDGTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI55</accession>
    <name>A0A0R3WI55_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000018">
        <property type="protein sequence ID" value="VDM16163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI55"/>
    <dbReference type="WBParaSite" id="TTAC_0000025901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000025901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000025901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283281at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132802" evidence="1">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000025901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15935" checksum="D626880D3FC671B4" modified="2016-01-20" version="1">MCILKLPHSSFLPILLSTLCIYAGASDSNIDDVESLRSLLFAPNSGEVIAAFESFQSSVCSPADERFQRQCFSELPADRYEVLEGSPVRMRCRVSWQSGKAQWRAHNTLLGTCHIRLLYQTRSGSVGSCDPHRSAFKIRFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIB5</accession>
    <name>A0A0R3WIB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-dependent kinase 2-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS333</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDK2AP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000025">
        <property type="protein sequence ID" value="VDM16259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIB5"/>
    <dbReference type="STRING" id="6205.A0A0R3WIB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000033201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000033201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000033201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9628807at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF3">
        <property type="entry name" value="CDK2-ASSOCIATED PROTEIN 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000033201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8752" checksum="E2D67CDC87D91E45" modified="2016-01-20" version="1">MAGQPNPSMQMIQNQQVCVDGLTKYAHLLQVIDEMGRDIKPTYVNNKNAAERLKKNIHSARILVRDCVAELERVMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIH0</accession>
    <name>A0A0R3WIH0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centromere protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS396</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000033">
        <property type="protein sequence ID" value="VDM16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIH0"/>
    <dbReference type="WBParaSite" id="TTAC_0000039501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000039501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000039501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261321at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000039501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16166" checksum="803D1709C6BDDA04" modified="2016-01-20" version="1">MEKICTSFIERSRLEEQLKETETKAALAEQELKASLLLQLPEFDELFQLKKSILKLAWRELQQIFAQNQEAEYHLEAQMVKCQRQRESEENRLNGGFLQLQNPIFTELGIRETRDFDIPEVDIEALRAKQPVIQKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIK5</accession>
    <name>A0A0R3WIK5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF4200 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS437</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000037">
        <property type="protein sequence ID" value="VDM16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIK5"/>
    <dbReference type="WBParaSite" id="TTAC_0000043601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000043601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000043601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251942at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="37"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000043601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40730" checksum="B4B32B2E4D15888B" modified="2016-01-20" version="1">MEPANMFASFILGDPSEIPEVIQENEKLGLLYASIGKIRGEIDIICTDRRLFVKKWERLLRELEELSQEKNRLVHTSLDVLSEREKLVKKIRAVSAKNKKDKDLIDLEIKERQRTNDYMSRLQVFIKVKSKSRYKHSIIPKLDQAATYESEISHIEGFEEVLNKLGNMLGVTDVEEIVKLFESKEAQINRAFEYINVQESKSSKIKEEIDRLEEEKARTIDELKASADLFREQILRLDEKYVGIKTETVALTKSLNKARKLAKHILREIAFLKSIVHFDTDLEADLDTPASSGLKKTMMALEQQICQIYDLYKGLKNKSGDAMAAEVSDTSSNLQSDSAINEDNSTTDGIDDLPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIN3</accession>
    <name>A0A0R3WIN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TATA box-binding protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS470</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000041">
        <property type="protein sequence ID" value="VDM16495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIN3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000046901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000046901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000046901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000046901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25775" checksum="0A2644D16824F612" modified="2016-01-20" version="1">MGSEDHASSSALGDSGPLLVHNNVVSSVDLACPIELRKVVMYIRNAEYNPRRFTGCVIRLREPRVTCLLFSTGKMVTTGGRSEESNNLGARKCARVIQKLGFPVQFNNFRIQNVVGIVDLKFPIRLEGLLMANEQMSQYEPEIFPGLIYRIINPKLAKRTKKVGIVGKYGTRYGASLRKTVKKIEEALRRKAAGIWACKRCGKQIAGGAYVCSTTAAATTRAAIRRLRETLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJL4</accession>
    <name>A0A0R3WJL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allatostatin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000116">
        <property type="protein sequence ID" value="VDM17109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000086901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000086901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000086901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263004at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132826" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000086901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9561" checksum="DC23D648AC6F94E2" modified="2016-01-20" version="1">MQAVVLTLGLLMAHLEITTAVAVAVPSPLRSSVSVDDPNAVLPVMESLEPKDTELYYLRQLQDMRNRMNAYRTSKRFFCNPYGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK45</accession>
    <name>A0A0R3WK45_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1075</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000172">
        <property type="protein sequence ID" value="VDM17416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK45"/>
    <dbReference type="STRING" id="6205.A0A0R3WK45"/>
    <dbReference type="WBParaSite" id="TTAC_0000107401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000107401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000107401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="420"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="472"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000107401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="605" mass="66522" checksum="FB8ADF3C16853A62" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK56</accession>
    <name>A0A0R3WK56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF4200 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1087</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000176">
        <property type="protein sequence ID" value="VDM17439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK56"/>
    <dbReference type="STRING" id="6205.A0A0R3WK56"/>
    <dbReference type="WBParaSite" id="TTAC_0000108601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000108601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000108601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="4">
        <location>
            <begin position="261"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="437"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000108601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="688" mass="78547" checksum="A59B69469EA10818" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK98</accession>
    <name>A0A0R3WK98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1134</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000191">
        <property type="protein sequence ID" value="VDM17518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK98"/>
    <dbReference type="STRING" id="6205.A0A0R3WK98"/>
    <dbReference type="WBParaSite" id="TTAC_0000113301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000113301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000113301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261944at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16123">
        <property type="entry name" value="RA_RASSF7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF6">
        <property type="entry name" value="GH01133P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000113301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28668" checksum="160EE8C883474393" modified="2016-01-20" version="1">MASPVSIESEMELRVFVNGKPRDVCGVDENTTAEDVVNVLCESLSLAGYYCLVAYWRKNEIVFSPSESPLNVITRVGEHPKQFQFVLRRTDVHRSPNPARTRSPIPTSHHHRRTLSNSSQCIPFQNAATSYKVAAAFAGRTQELDIGCTAELQQLSMVDWSRRLEEERQHQLSLLTERSRLQRDLQRLDTELRQVRGKVQGLESEMASELTNLLNAVDVALEGRRKIVADLLVASEALQLPASSRPTPVCDEVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKK2</accession>
    <name>A0A0R3WKK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000233">
        <property type="protein sequence ID" value="VDM17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000124601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000124601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000124601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000124601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13350" checksum="6C089A2813F3AB15" modified="2016-01-20" version="1">MRAELQQSRAASTRHDKCVQSPQTCLLLRAGYAPRSVVADRSEFGNDSNSRTVATVAAHSVVCYDSGGITGRSCANKSHETHSCLADTSVGPTIPPRILKLERSVITVQVTVLLVVVEAWRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH4</accession>
    <name>A0A0R3WLH4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1599</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000397">
        <property type="protein sequence ID" value="VDM18268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000161201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="659"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="750" mass="83269" checksum="BBFA5B92ECA2DBA5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLI1</accession>
    <name>A0A0R3WLI1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="11">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1606</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000400">
        <property type="protein sequence ID" value="VDM18277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLI1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000161901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="59910" checksum="2FE5EA40B4E53D71" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLX7</accession>
    <name>A0A0R3WLX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1752</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000489">
        <property type="protein sequence ID" value="VDM18492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000176501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000176501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000176501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000176501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12521" checksum="5F6B48D6DDA667CE" modified="2016-01-20" version="1">MHLSVYRANAESHSWLDDTGTGTMAPGLTLMVTLTSIFLQLTLSAPSTKATSLVTIEVEENSKLSPAVLSSAVWRAVKDTAKKVGKAIKEFVVNDVVDRTYTTVKNWATWRFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM80</accession>
    <name>A0A0R3WM80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase SHPRH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1855</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000557">
        <property type="protein sequence ID" value="VDM18595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM80"/>
    <dbReference type="WBParaSite" id="TTAC_0000186801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000186801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000186801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10615285at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000186801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21315" checksum="6A9BC7C026846AA4" modified="2016-01-20" version="1">MMESVDEKGGQVVSIKETQVGKLDSVSHTIEVEPKSKIPKLMKQDTGKNASSHSLLPTFEEEEEKENNCLYRSRAIAKAGMLQAKTVVNAPSFADLLIYAQEVLMLTAELNQLGVALLQALLLKQKDKTVEIYEKCDCGLRELATMIKLVNRCEGRQKARAIFTENELYSNIPDVSIEPPEYCIIVGASPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMG0</accession>
    <name>A0A0R3WMG0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DOCKER domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1935</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000617">
        <property type="protein sequence ID" value="VDM18675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMG0"/>
    <dbReference type="STRING" id="6205.A0A0R3WMG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000194801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000194801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000194801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="3">
        <location>
            <begin position="672"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000194801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128572" checksum="7A3B9C9054202273" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNI0</accession>
    <name>A0A0R3WNI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lysosome-associated membrane glycoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2305</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000945">
        <property type="protein sequence ID" value="VDM19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WNI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000231801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000231801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000231801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6232933at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132935" evidence="8">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000231801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="28562" checksum="B8A22FB4DB5E754F" modified="2016-01-20" version="1">MSVVFALMVVVLTPFVVDVTSTNGSEIAAFGSTKAVVGNTTSIVEASTTNSTDEVPKFEFVCNGTINVIIQARMELFIPYFDGQSIQTKSFVVGKNASVFGGCGDEVENILFQWSPNASNVPFNLTMVIQKLPRSPSRSGSTVVHAIGFDYFVSSDVFPHTNSTGALSVSVNGSFFETPGTMGFTCAPSQNISLSGGVIFGVSCLHLEAFRNSTSKDFSWKALDCMDAPAVNKVVPIIVGVSAAILILLVIVAFLISNRRRVQGYQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNN5</accession>
    <name>A0A0R3WNN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2360</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001001">
        <property type="protein sequence ID" value="VDM19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WNN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000237301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000237301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000237301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000237301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="53396" checksum="4138594BDCBD5EC7" modified="2016-01-20" version="1">MSNLSRKEELEIKKARLAALREERLHREALRKKGEHSANISPIPHVKGVDTEKILNDLGVGAVGKRVLGVKSSSVFKSQSSPSLESKAASRKPLKLVTSGLNECSFEPVNEEMYSKETQTTNDVPCETPSITTDTWPETPSMANGPASRAQMSLEWDDELLAADGDDPLTDIEVPPISNQVEVEKSVRLQDPNTSSRNMGNDGFSVLYYVLGEEMTDEDKENILSSEAFQDFFLRASTIVEGALEEDERDIFFDYSGADKEEELAKAQQMLTEDCIFFDDFWTSKRVVTALDWSPNHPEIVLAVYSAIQRDEPALTPVNLYAAAATADGVCVLWNLKSKKSESAQESVFTCQASITTAIFSDFHPNLIIGGTNGGQIVIWDIRVNRETPVQWTGLCGNLVHWGPVRSIAVTGNQDTNNLISVGADGRLCGWSLDMLAKPFQTMELVYKQAKLVAPTSVAFVQDFDDSFLIGAQDGCIYSGCRCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNQ6</accession>
    <name>A0A0R3WNQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radial spoke head 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2381</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001015">
        <property type="protein sequence ID" value="VDM19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNQ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000239401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000239401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000239401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000239401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42131" checksum="F5A1E1F8F273FC4F" modified="2016-01-20" version="1">MSEDDVEEGEDEVYLGVYEGGRNEKGERHGFGKAILPNHDTYEGMYENGLRNGKGYYLFKNGARYLGEYFDNRKHGQGTFYYPDGSRYEGYWVDDKRNGHGTYFYTNGDTYEGEWRDHLRHGKGTYTFAVTGCKFVGVWRDGLMDGSGEVINAKYRFLGMWRKGQLIGEGKYVFDKLNCQQTGEYLLLPGEPEEKRQGDDDSFTVSRWRARAIEVARLDEPATEVDVSEMRSVDKDICGFSICQAHVTPYFPIFKAPRSNQMRAPSSSQAKSSRESVDKVDPICTENPVDVVVSGDYIRQDVNSAHKEVEDAPCVEVTDSLASKKENEGSEENGVEVQDGSLEEVEESEGEETTAMLGSVGKVQTEASEESSTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNX5</accession>
    <name>A0A0R3WNX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2450</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001094">
        <property type="protein sequence ID" value="VDM20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNX5"/>
    <dbReference type="STRING" id="6205.A0A0R3WNX5"/>
    <dbReference type="ESTHER" id="hydta-a0a0r3wnx5">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000246301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000246301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000246301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9000293at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132920" evidence="6">
        <location>
            <begin position="21"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="38"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000246301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="655" mass="74628" checksum="141315CFE66C91F1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP63</accession>
    <name>A0A0R3WP63_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 13">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2538</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="UYWX01001184">
        <property type="protein sequence ID" value="VDM20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP63"/>
    <dbReference type="STRING" id="6205.A0A0R3WP63"/>
    <dbReference type="WBParaSite" id="TTAC_0000255101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000255101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000255101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000053">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="52"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000255101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27433" checksum="7DA99096A0364DFC" modified="2016-01-20" version="1">MNPSRVERGSRIRDSEPVNLAIGFNGFPMTAFCIPERYVPYLDKVLVSNGMIKDRLQRLAAHIVESYEHLEINNVSIMCVLKGGFKFFSDLVEEMQRIIWSRNAQLCIAVEFIRVKSYTDTVSGTVGIRPIDNAMPIKDKNILIVDDICDTGKTLVKLSEYLAEAGAKSVMTCCLLLKHTDLNIGYRPDFLGFEIPDEFIVGYAIDYNECFRDLSHICSINEKAKVTFSSHSDVELGKLPTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPF8</accession>
    <name>A0A0R3WPF8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2633</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001307">
        <property type="protein sequence ID" value="VDM20728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPF8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPF8"/>
    <dbReference type="WBParaSite" id="TTAC_0000264801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000264801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000264801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132931" description="Homologous-pairing protein 2 homolog" evidence="9">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="10">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="11">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM20728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000264801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23968" checksum="26A65D714300C89B" modified="2016-01-20" version="1">MSKNPKGMITLLSILLLIADVLAYMTRENRPFSVNDIVTALQKAHGKTVISKAVDELVLDASLVEKVYGKQKVFVVSQVRAAAFPYHDCEEKLPRPDSSELKAMDDKINELTTNLQQLRDRVRVVESELKSVQSSLSLQEARDQNAVLEIKIGEIKKLISEYGSEPPVPPEEFSQAMDIVDAVAEGYPKSRKELMDDVGIETDEDRGVSIADFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQL9</accession>
    <name>A0A0R3WQL9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1990 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001842">
        <property type="protein sequence ID" value="VDM21812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQL9"/>
    <dbReference type="WBParaSite" id="TTAC_0000305901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000305901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000305901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000305901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18238" checksum="7707D61677460562" modified="2016-01-20" version="1">MMNRYTEKTANCPDAEMLEAFRTGHYQGRGCFSRLPLRTFDCDWSAAFNGGKANVQHPHFRWACGSLGFDVGLNNPAFTVEDNRTRLLSTCTVIGFECLSSLSKLTVTSVRFELQMVDRNFGYLYWLQLLGRAFEGRWVVPLQARMANCRHFLQHLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRX9</accession>
    <name>A0A0R3WRX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3504</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002545">
        <property type="protein sequence ID" value="VDM22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRX9"/>
    <dbReference type="STRING" id="6205.A0A0R3WRX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000351901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000351901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000351901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000351901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41218" checksum="BFAE1F8D86D03977" modified="2016-01-20" version="1">MDRGSLLKVYSAIDELCRTRKSIIYKARHRLTGVTYCIKRSVHGSSLKDCCEESLSNALNECQALSVLRHRNVVRFYNSWFEAGAVLMQLEYCVGGSLSDCLRTTRDSGVLSGTAIGKLLSDVAGALNYMHTKWCMAHRNVGLGTILVQLKPQVASHLAFKSDEEAEEARTCCHQSLMSGESDVVDFKLASFGKASRISEAGDDRGVDVYALAVTVCLAAGGSAVSHGGNVLNVMNLSNIPLSLHSVLQSMLEPSGADRVSAGEVVEHLAIHHNDVTAELLLTQVISYWPVFVGYGLPLGALDAPSSVSIWSELLSAFLYPILVVGAFQAARHKALDPRQHRVSLRLHLLAALSMKPALCISSQLSIHAILSRYWQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS33</accession>
    <name>A0A0R3WS33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3558</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002636">
        <property type="protein sequence ID" value="VDM22870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS33"/>
    <dbReference type="STRING" id="6205.A0A0R3WS33"/>
    <dbReference type="WBParaSite" id="TTAC_0000357301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000357301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000357301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288864at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000357301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="21494" checksum="837E0F6BA61633ED" modified="2016-01-20" version="1">MPTALSSTSAKSRDVVNIVIPRGPIGFEFSIKSNEIIFEFSDLIWDQFRLSALRLVVIDLPLPLGPHIVISKVREGGTAELAGLKCGSILQAVNRQPIDGLSFLQVSNMIRRTSGFTAELSVIEPDEVSAVSGNGDSLVPSSTSSSRCSIDGVVLRNSHSNPSATSLNCSISSSAVSVSCAFPNRQKFLQSSKHCNAVTCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSG8</accession>
    <name>A0A0R3WSG8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCDC66 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3693</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002883">
        <property type="protein sequence ID" value="VDM23163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSG8"/>
    <dbReference type="STRING" id="6205.A0A0R3WSG8"/>
    <dbReference type="WBParaSite" id="TTAC_0000370801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000370801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000370801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044099at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000370801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="62199" checksum="33800A8E12476C49" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM3</accession>
    <name>A0A0R3WSM3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3749</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002975">
        <property type="protein sequence ID" value="VDM23280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSM3"/>
    <dbReference type="WBParaSite" id="TTAC_0000376301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275668at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22824" checksum="A00BF2FF4DB24994" modified="2016-01-20" version="1">MVSVKALTPTTWKNSGFKYPNFTTGMEGDEVVQLPDALIAVDGSRVYEPLIMFNYLIEDDDVAFSLEFQPQPLPPQACPQFLVVARHIFPPNLAAQSDGRGEDFWAIIPPQTSVCTKGTSLEEVERNHTFFVSNVDFHRAKVSALELARGVKMTRKDANTFFVGYRQLNEEEVDRYSTENPPPRPYPHESQINVTARVRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WST2</accession>
    <name>A0A0R3WST2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS3806</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
            <location evidence="12">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003089">
        <property type="protein sequence ID" value="VDM23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WST2"/>
    <dbReference type="STRING" id="6205.A0A0R3WST2"/>
    <dbReference type="WBParaSite" id="TTAC_0000382201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000382201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000382201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917245at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06722">
        <property type="entry name" value="PDZ_PICK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000073">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF1">
        <property type="entry name" value="PRKCA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="PDZ" evidence="14">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="15">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000382201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26395" checksum="25534032EA4735F7" modified="2016-01-20" version="1">MIVTSGSVTLNKDPQNLVGISIGGGAPYCPCLYVVQVFDNTPASRDGTIQAGDEITGVGGVRVKGKGKVEVARLIQSFPVLTNSKIFQESVTIYFNKLHADPKQGKTLDIVLKKLKHKMVENMEASTADALGLSRAILVNGMFRMSSDSLVKKMDELNRTALMFSGLVQHTRSLVRAIFQLSKVHRTFGEIMSQIGVKEPQVRAGQAFTHFGEAHRELEKFAVGTLKQLQPVCFLHVLLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTL1</accession>
    <name>A0A0R3WTL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Titin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4085</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003633">
        <property type="protein sequence ID" value="VDM24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000410101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000410101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000410101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10504090at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000410101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27150" checksum="E64EDEE85A71CDDA" modified="2016-01-20" version="1">MSDNHEDVGGGRGLVTITTDGMEALNTNGTKEIVPPDSPKKGDLYVLSTTVAADGEIEIRRTLVEPGERTDSFTPDNDTSITPVKESLPRLEGPSPRLPLPSPSPEENRCEDNQQREKIKRTEVQQPLGDVPFTTEEDAVKGEPQDRLEVMEGVERMKDHDSVPSEVIEDSEEFNEELKVEIQKMIDECAAAIQEEKQVETEKESGEEVKEIKGEHQEVLQVEEEEKENLVVEAKEVDTEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTQ8</accession>
    <name>A0A0R3WTQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Complex1_LYR_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4133</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003733">
        <property type="protein sequence ID" value="VDM24251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000414801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000414801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000414801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000414801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17345" checksum="E75A00F05E960CA2" modified="2016-01-20" version="1">MDPVRLMHELYPELEILVTECLATNNAFGNLRRTKTNVNSQRRQRVRVVAKYKGRLLNGEGFNLRTAKLKIAQQLGIGELLRASNNFTDYNFRTYFTRRIKEEFRKHEHSKSSEEQDKFIAEAEKILGILQRQSALSNFYRGLKLPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUM1</accession>
    <name>A0A0R3WUM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4446</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004460">
        <property type="protein sequence ID" value="VDM24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUM1"/>
    <dbReference type="STRING" id="6205.A0A0R3WUM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000446101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000446101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000446101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000446101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20618" checksum="9A9DB395A7B0D167" modified="2016-01-20" version="1">MVEVTHGVSGTLIGEDSSQSLTSPKLHVSSGRPSDDHMAAIRRTAASKRSLLKMRASRSTTSRSRSDLSSSRDESKSPSSPGSSADEDPKRSKAERSSSDSECSPSESPKASLDGQIRPLFQRRTRNHSAPMILTPIESCATKTSNSPAIVCELSRIPKNRLQKLLKSEPNYHPNNAFLYYVDPTVFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUS0</accession>
    <name>A0A0R3WUS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4496</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004593">
        <property type="protein sequence ID" value="VDM25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUS0"/>
    <dbReference type="WBParaSite" id="TTAC_0000451001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000451001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000451001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000451001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8876" checksum="208EFCE821959902" modified="2016-01-20" version="1">MLQQVASATPAPQPNSVTPPDWNLLTPEVADSRHGRGCTPSSARTPSSHFGDEHNIPSPTPKTQTDLEKGTALTLNSAVQFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV09</accession>
    <name>A0A0R3WV09_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2235 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004816">
        <property type="protein sequence ID" value="VDM25228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV09"/>
    <dbReference type="STRING" id="6205.A0A0R3WV09"/>
    <dbReference type="WBParaSite" id="TTAC_0000459901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000459901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000459901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419333at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018881">
        <property type="entry name" value="C2orf69_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296">
        <property type="entry name" value="UPF0565 PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10561">
        <property type="entry name" value="C2orf69"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000459901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29072" checksum="56B5AE094954F685" modified="2016-01-20" version="1">MSAHPQFGGLAENWSFEAVASLLLNRLEVVSGVHLWIVRASQWLLDTFACYTNFVRYTGSGVPDYSGIHGVGGTSSAWRHLDALLKNAAAAVDGASFELPCVIIGFSKGGSVVTQLLYEIGLFFDLPEFSDVRLTSQVVSLTWLDSGHNGVTHLWPTWTVPIARLRRHPSPPKLLAFATPYELCDENRPWNNRDFGTFIRLLKNFRLPYYFDTFYKGHHWDYSFEFPQTLRVGIDSHFEILACFPIHLCMPTSSTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVR3</accession>
    <name>A0A0R3WVR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DBINO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4838</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005458">
        <property type="protein sequence ID" value="VDM25747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVR3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000485301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000485301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000485301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000485301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19961" checksum="9DDDAC614DDFA8CC" modified="2016-01-20" version="1">VNFDRNKHLSDLSVRRRKAARVQLEAAAAAAEEETRRLRAEREARAQELVAKADAEAQLAAKRAEEKEKEARKEELLQALAKRIKKERAKRAREETTEQTTGHDKKRRKRLQIKSGSEMRVSSPTEAGAERMREKLLEKRELQLRARLLSASSQFTLYQKAERKDANPHLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW87</accession>
    <name>A0A0R3WW87_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOR2-PAG1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005945">
        <property type="protein sequence ID" value="VDM26063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW87"/>
    <dbReference type="STRING" id="6205.A0A0R3WW87"/>
    <dbReference type="WBParaSite" id="TTAC_0000502701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000502701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000502701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000502701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20017" checksum="6CB7470E374B6FFA" modified="2016-01-20" version="1">MADPGYHSRTLLASFVYQPSAAQVLRVIQWLMEFSPRGLPHAPSAFIHACFVLFLVRHLNAHLPAAESAACEHPNVVGYTYSLLSLTWEPTATWQAYSHKDCLGVLIALHLSSPFFGPSASPLNECLEMLVNLVKFSLQPLLQGRDRDSGNTSQQTHLCYSGLTTETAGLYGRKVLEVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWL1</accession>
    <name>A0A0R3WWL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHC_N2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5136</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006359">
        <property type="protein sequence ID" value="VDM26337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WWL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000515101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000515101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000515101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266757at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TRPM-like" evidence="5">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000515101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20890" checksum="3391B48A21D51577" modified="2016-01-20" version="1">MEYLEGGVNLYADNALDDTELDETESSERILEIMFQHWKEEEIQQDTLDMVLKIMAYSQLIEFFYSDKGSERTLDECILSSLINPALFQTQEIQYTWKPRLKIALELDRLGVAIEKILDGAKWTPKEMAPFVKSSFLKNKVDFLRMFADVGFEIHEFATAKAVEELYSVEAHRNVCSATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWM3</accession>
    <name>A0A0R3WWM3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tubulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5148</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006396">
        <property type="protein sequence ID" value="VDM26357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWM3"/>
    <dbReference type="STRING" id="6205.A0A0R3WWM3"/>
    <dbReference type="WBParaSite" id="TTAC_0000516301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000516301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000516301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="52"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000516301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31430" checksum="77FBD6D7AA1EA407" modified="2016-01-20" version="1">MPLGEVISVFAGQCGTQVSQAVWELMAVEHGVGPDGMLIDPSAESDYDKQSGNVFFMVDNKDRYVPRTTIVDTEPTVVDEIRCGLYRTMFNPRGLISGLEDMANNFARGYYGVPQTLIDTTINSIRKEVEHTDLLQAILFCHAYGGGTGGGTACRIAELLDTEFMKIPKIEVAVFPDHQKSCCVVEPYNAILCCSTLDDISTFSVLCENEALTDICTKKLGIERPAFSHLNRVVAQATSGFTATLRHEGPVTASLLQLQTNLVPFPRLRYLQLGLAPLCTADVMSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWN2</accession>
    <name>A0A0R3WWN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5157</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006427">
        <property type="protein sequence ID" value="VDM26369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WWN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000517201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000517201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000517201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000002">
        <property type="entry name" value="WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF373">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133034" evidence="4">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000517201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8295" checksum="C1BFA43FD7888DF2" modified="2016-01-20" version="1">MLAFLSLQLLLLSAVGFGQDEEDVCSLPLESGPCMAYFKVWGFNSATGQCENFVYGGCGGNGNRFDEKEECERVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWN8</accession>
    <name>A0A0R3WWN8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5163</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006456">
        <property type="protein sequence ID" value="VDM26381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWN8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWN8"/>
    <dbReference type="WBParaSite" id="TTAC_0000517801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000517801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000517801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6219927at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000517801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10887" checksum="3A77CFEDA096B7CA" modified="2016-01-20" version="1">MAMGIVGRHGIGSNHSKRPPIRVIIRITDMTEELQLMAVNTASDALDSCNKPRDIARFIKKTFDEQLYPGWLCVVGQAFGSALSSPVKTTAKNFFKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX31</accession>
    <name>A0A0R3WX31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCV_T domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006962">
        <property type="protein sequence ID" value="VDM26661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX31"/>
    <dbReference type="STRING" id="6205.A0A0R3WX31"/>
    <dbReference type="WBParaSite" id="TTAC_0000532101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000532101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000532101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000532101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11846" checksum="8FF7F730C6221A05" modified="2016-01-20" version="1">MGVLGLTSDKAKIVQNLGPVDFDAVVKEREKFIYVPSWFSVDLRCGFPIIHLDSSDALSAHITLKDAGFGSPEDASDQKSMFGQSTTASSLSQPLLVCRCTASLDTPVPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX84</accession>
    <name>A0A0R3WX84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS5358</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007180">
        <property type="protein sequence ID" value="VDM26791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX84"/>
    <dbReference type="STRING" id="6205.A0A0R3WX84"/>
    <dbReference type="WBParaSite" id="TTAC_0000537401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000537401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000537401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM26791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000537401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25764" checksum="CC31A9E0351CE6BA" modified="2016-01-20" version="1">MTLMTSTLTDQIPATMIMLGIFCSIGCIGNTIVIVIYSTKHDRLTSTVFILALAMVDSFACVCLMPLTIYIESVEWRIQSEFLCKFYYVINNSFIPFSSLLISGIAFDRYFAICHPFSKIITVSRAKQIIIVMLSLALLLGGVSSMTIVVKLIPTGNTSAPEYECTETRMLNTTKTQMVIYHIVQGSQISSYVLCILSVIILYVLIFRSVLIVRFVSFFYLTFTRILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYC9</accession>
    <name>A0A0R3WYC9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5752</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008890">
        <property type="protein sequence ID" value="VDM27598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYC9"/>
    <dbReference type="WBParaSite" id="TTAC_0000576901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000576901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000576901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6113578at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000576901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="37" mass="4067" checksum="A08A5CF808E6E444" modified="2016-01-20" version="1">MFTVGLDVKTAVFFSSITMIIGVPTGIKIKCYMILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYL5</accession>
    <name>A0A0R3WYL5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5745 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5838</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009314">
        <property type="protein sequence ID" value="VDM27781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYL5"/>
    <dbReference type="WBParaSite" id="TTAC_0000585501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000585501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000585501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000585501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12002" checksum="DEE02A167CC015FF" modified="2016-01-20" version="1">MALPDDDGQEMLAIMRGSVFLTLNLLPTIQDVDSTSQPLITTVEDRLIALLFTIGDLMVILDSLLQAHLATRETAEVGQKAPSLMDSMVTCRMTKRNTQRGMHADDSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYP3</accession>
    <name>A0A0R3WYP3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LITAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5868</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009423">
        <property type="protein sequence ID" value="VDM27839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYP3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYP3"/>
    <dbReference type="WBParaSite" id="TTAC_0000588301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000588301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000588301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000588301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14622" checksum="424765AC932927AC" modified="2016-01-20" version="1">RPHRRNKLPFFQFPCQGHCEVGWAYIITIVGGVITLLSTLVPCGMPLNAAFQTPIMGKQDCVEMPNGIYVSSTPVPLLPMRSTATPTDQSSLNQGSFSRKTSSVQGVVAMTSSTYVSAPEFRVLIPTTSVIVQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZD7</accession>
    <name>A0A0R3WZD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5'-tyrosyl-DNA phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6135</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZD7"/>
    <dbReference type="STRING" id="6205.A0A0R3WZD7"/>
    <dbReference type="WBParaSite" id="TTAC_0000615001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000615001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000615001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000615001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47965" checksum="C040AAB1B4CB8F8C" modified="2016-01-20" version="1">MEVDSSDDLPSEKECLKRCELFSHLTNTNNALAMMFLQKASWDVEAAVQQFYETTNDSPERSGSKHQSPSFAPIIDLTLDSDESVVLNEGSDAEEEVVDKQHAHLFRLLSWNIDGLSVQSRDFRTPAVVTLIKSEKFHVVCLQEVVKETLVYITEQLTSLYEVFHPQDVQCRDYFPVICILKHPSLSVLPNTFQLEVDAFWDWQLFVKATEHAVTHFPGSVMQRILLSLDVVLDVPRLLRTNPNAKFWKRIPLRVRLWTSHLESCNQFADERKCQLKRVWEDMRAAIHPIYSTTNAPLCGIFCGDLNIRDKEVRELGGLPEGMVDVWEVCGARPEAKATWDPVRNPNLQLDQKESSASRSRPPAHGLRFDRMHVLGRGLHPVDFELRGLERVPRHSHFPSDHWAILGHFDFDPPPTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZH3</accession>
    <name>A0A0R3WZH3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000619301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000619301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000619301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000619301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9569" checksum="7C959E18E933D9BF" modified="2016-01-20" version="1">MECLREDVGDGVERGMRHLSSTDWVGIEVIGMRDNTRLVYFRLRLLHLLRFTLQPLEVVALVPCLGAMALIGQRILHIGTVSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZM1</accession>
    <name>A0A0R3WZM1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6240</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZM1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000625501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000625501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000625501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000625501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="484" mass="52044" checksum="D01918C61A616681" modified="2016-01-20" version="1">MLLILGVDALGWELVKAKLSELGAFADEELPDYITVMVANKKKRSSMVKDLQLFLGNQTELFTDWRTRSRSPITSVKPSSEEPIVADVVNVQTDESIMDRFALNILDEFTEENSHSLSGDGKRDSVLKPTEQRRVVSTSSLGSKSTQKSSEELPAVRSVVKVSTNAPPSQSSNIATATSAAVGGMLLKRAMNEARASTAQVQERPAAVVRGQKRPIEKSETASVSQEKTAVSVNEVDLVEVPTKMTRFVVTMGEEPLLLKPSVKSRLGPRVVAPITNTSNSVEMLDAREILIAKKSQVKSPRMQIILGDSFGEDEEEDGGDGVESDANAIFAFESGDGKSEDPKPGRSNIPRQGFDPEFFGDYSTVSSLIPKVVCRYFPHCKLPAGTCPFYHPPVPVCRFGAACLNRGTTCPFAHPIPAAKPKAGLVPIPSSKLKWVAPGKSATFAASTTSMRKMSPSSSEKIARPTTTATSISAEPTSAEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0S4</accession>
    <name>A0A0R3X0S4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat domain, L domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6741</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020320">
        <property type="protein sequence ID" value="VDM30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0S4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0S4"/>
    <dbReference type="WBParaSite" id="TTAC_0000675601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000675601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000675601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000675601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="672" mass="77394" checksum="2B52A1907EA8F70B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X107</accession>
    <name>A0A0R3X107_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6836</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X107"/>
    <dbReference type="WBParaSite" id="TTAC_0000685101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000685101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000685101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:ceramide kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
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        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DAGK"/>
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        </location>
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        </location>
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        </location>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM31108.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000685101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1664" mass="183152" checksum="6DB20866D35EA1B9" modified="2016-01-20" version="1"> </sequence>
</entry>
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    <accession>A0A0R3X185</accession>
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        <name evidence="1" type="ORF">TTAC_LOCUS6929</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <dbReference type="EMBL" id="VDM31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000694401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14674" checksum="A9CC8DCA8F1E3583" modified="2016-01-20" version="1">MRFRDVGLKHSSFIIHLTSGRKLIFYSTSSQEAQYLFALSSHLHEHQTVAHLASQQSARQLEQQDRLQYNEAYVYSAGEVVTTRRIHAAPDSQAKGRMLMETVESSLFPQLSNSNLKGDMDEPTQSVYI</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TTAC_LOCUS7126</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <dbReference type="EMBL" id="VDM31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000714101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21053" checksum="600CF3C27A9EE3C0" modified="2016-01-20" version="1">MGGCAEACWSSPDSLVIDAVTEESRLQAVVEAVIQLCAADNVAEVAVIVHLTALLAAQEHAPPSDTHTCTHTSTQPDTMVAIVAASRSSVPVDECNGVTYFHVFDGSLWCECLVREMWVDGSEADEEGGGGGGGGGGLEVEGLTCVPLAIATLLVVTSSHPMRQLTSTFAPTWLIVLPSSHFHLERGGTHLLTVKWESTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1S3</accession>
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        <submittedName>
            <fullName evidence="7">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7168</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020350">
        <property type="protein sequence ID" value="VDM31505.1"/>
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        <property type="gene ID" value="TTAC_0000718301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439993at2759"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="La_HTH"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="469"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000718301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="793" mass="83583" checksum="6831A0563C516EC9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X212</accession>
    <name>A0A0R3X212_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7276</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X212"/>
    <dbReference type="STRING" id="6205.A0A0R3X212"/>
    <dbReference type="WBParaSite" id="TTAC_0000729101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000729101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000729101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000729101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="62666" checksum="8EC9160411B32AE3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3B4</accession>
    <name>A0A0R3X3B4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7814</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020407">
        <property type="protein sequence ID" value="VDM32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3B4"/>
    <dbReference type="WBParaSite" id="TTAC_0000782901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000782901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000782901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000782901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20446" checksum="B59BBC4ECA4375F9" modified="2016-01-20" version="1">EEKEEEEESKEDEEKEEEEKSKEDEEKEEEEEEESKEDEEKEEEEEEEEEEETIVVATHRKPKWKVVMMQTLSFNWLVEAVVDVGLVVVVVGGAVVVVVVEDDDERVVVDPPRLSLSPCQRDRANGMGMEKIELVSWLAGLERSPGCLTGDSIGWVVSPLLLAATAVTAAAVPNGQFLSCISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3N8</accession>
    <name>A0A0R3X3N8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7959</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020425">
        <property type="protein sequence ID" value="VDM32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3N8"/>
    <dbReference type="STRING" id="6205.A0A0R3X3N8"/>
    <dbReference type="WBParaSite" id="TTAC_0000797401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000797401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000797401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="80"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000797401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41758" checksum="2CE6591A21A42CEA" modified="2016-01-20" version="1">MPHQNRSSHVNVQGEGKKAETPHLKQNGLAEDAEKRGMRHPAPFSHEPAALRALEECDYSKKITLQMAKSGTAPRRVRVYADGVYDMFHSGHARQLMQASNAFPNTYLIVGVTSDADTLFHKGQTVMSERERYEAVRHCRYVDEVIVAAPWECTIEFLRLHKIDFIAHDDIPYASDGSNDIYQPFKDAGMFLTTQRSEGISTTDVIARILKDYDVYLRRNISRGLTRHELNISYVKEKQLLLENNIQTIVERGSHFFGDFGTRRRRIVAGLEDLYQEFSASFLRFFGTQGLLRHWLSDTTAAIRGVVSPHSSVSLPPSPLSNSNSNAAGENDTTSPYRSVLVGTDHSGKRPRFKSDDSTIDCAARKRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4R0</accession>
    <name>A0A0R3X4R0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8396</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020497">
        <property type="protein sequence ID" value="VDM32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4R0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4R0"/>
    <dbReference type="WBParaSite" id="TTAC_0000841101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000841101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000841101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="19"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="702"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000841101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1251" mass="140958" checksum="069C6BE1C9F6DA5E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5S4</accession>
    <name>A0A0R3X5S4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8820</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020596">
        <property type="protein sequence ID" value="VDM33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5S4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5S4"/>
    <dbReference type="WBParaSite" id="TTAC_0000883501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000883501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000883501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058770">
        <property type="entry name" value="PWI_ABCF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="175"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000883501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51703" checksum="DF40EE138DC81008" modified="2016-06-08" version="2">MRERLASALGEVRKRYPDLDPDTDSYLEGIIIENGEHFESIDEVYEAIGGFLENLGGNRDARRCCTDVYNIIHPNGHVTTEERLDEPVHMAVLVNNFNERVIDTASIWMAKREVTSNIDAAKLAKAEARSREKQAKKLQNNDALSSKQLESACVSQQPDRKEKFSTTGTSKIVDLHIENFDISFGKRVLLRDANLHLSFGRRYGLIGRNGSGKTTLLRALANGDLRLPPGLSVLHVEQEVMGDNTPAIESVLQADTKRSALMAELAKLKEGQENDETSSRLAQIFDQLVAIDADSAPARAASILHGLGVEAQMQNRSTKEFSGGWRMRLALARALFAKPDLLLLDEPTNMLDMRAMIWLENYVQTWKGIMVVVSHDQAFLNAIATDIIHLVANRLDAYRGDYDAFVKAREERLLNEEREYLAQKAERDHIQTATTTVGGGWDEVRRSGVGGVRPNAPQYECCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5X4</accession>
    <name>A0A0R3X5X4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8875</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020615">
        <property type="protein sequence ID" value="VDM33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5X4"/>
    <dbReference type="WBParaSite" id="TTAC_0000889001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000889001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000889001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515313at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000889001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40600" checksum="0B0265635037A3CF" modified="2016-01-20" version="1">MSNNLHEFQNYDSSFYGDAIEELSAEKLKGYTVSDLTLRALTLCRFKRPSSYIECVKTEQGDHQISIVDDALTEKRLDESITLSNNLQSFSSSNLSDINSTVVEGEDELTVVASIASRSEECSHPCSSNRTSNDEETELGVTELVEALQHLSRDARFRSIRPLWRDPNSRLLPSDETASVEAMLREYNNLLLTAATTPNVSSSLNSQLAVRRPYHSTLNRWRQQERIQVENFILANRLRNIRPSPETSREALLKHYREYFITPVTAQCLTKMPTLDSDSSLPRCRPRCSSARSTQIGASRPLKSFNSSISSRATPAPPRASACGCTSTSRGSIVETPRSREVLKSLNSVRRALHEQRVKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X688</accession>
    <name>A0A0R3X688_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">PBPe domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS8997</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020650">
        <property type="protein sequence ID" value="VDM33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X688"/>
    <dbReference type="STRING" id="6205.A0A0R3X688"/>
    <dbReference type="WBParaSite" id="TTAC_0000901201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000901201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000901201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133250" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="16">
        <location>
            <begin position="519"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="17">
        <location>
            <begin position="529"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000901201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114466" checksum="82DCFACC2FB2D9B7" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6E6</accession>
    <name>A0A0R3X6E6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinyl-CoA synthetase beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9059</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020668">
        <property type="protein sequence ID" value="VDM33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6E6"/>
    <dbReference type="STRING" id="6205.A0A0R3X6E6"/>
    <dbReference type="WBParaSite" id="TTAC_0000907401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000907401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000907401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="10">
        <location>
            <begin position="24"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="9">
        <location>
            <begin position="305"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000907401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="429" mass="46330" checksum="6D4354F7D8ED7B78" modified="2016-01-20" version="1">MAFGALKKLLVNSSKLLQFRRSFNLPEYQSKILMNEYDLAVQDFRIASSVEEAERIVAAFKPNLYVLKAQVQVGGRKLGHFSSGGGSGIQFTNDPQEVPIIVSKMIGNRLVTKQTTPDGVVVNTVMIADAVDLKKERYLAILLDREACCPVVITSIEGGVNIEDVARASPDSIRQEFIDLQEGMTDAKSGSIACSLGFNHGSSQHTFMCSQLKNLYNLFVDLDCLQVEINPLGEREDGSLVNMDAKFSFDNNAVYRQPRVAALAAQSRKLDVEAAGEHSLLALETSADAHGLNYIGLPDGTIGCMVNGAGLAMATLDLLSLHHGRAANFLDLGGKASQTDVEFALQTLTADNRVKCILINIFGGIVNCRMVAEGIVAACLRQKPQVPLVVRLEGTNSMEGREVLRAAGLGIHIAKDMEEAADMACEIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Y8</accession>
    <name>A0A0R3X6Y8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9283</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020748">
        <property type="protein sequence ID" value="VDM34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000929801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="29468" checksum="B1AA74E4C27E7BA8" modified="2016-01-20" version="1">DGVANSIGSQEENNEDADCDADNRVAAKRQKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAAPHMYPTDSPSSCLGYMEGSQYAAYSRAAAAAAAGLASHSSPSEMYIAAAAAAAAAVGGASANSVAPVTGRNRRTGADVGGGGSGGGGGFIDSSVNPGDFFTPGYYPTPAAYGPSSYSSTTSSTYRPQYHTVGGNLAASYYPAMYNQLEEALPYTPPVGFAPADEAKKANAGSSANTSTNTSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X726</accession>
    <name>A0A0R3X726_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GPI ethanolamine phosphate transferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9323</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000933801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000933801"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00196"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="858"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000933801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="999" mass="109436" checksum="55C59322A479747C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7C4</accession>
    <name>A0A0R3X7C4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MHD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9434</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020816">
        <property type="protein sequence ID" value="VDM34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7C4"/>
    <dbReference type="STRING" id="6205.A0A0R3X7C4"/>
    <dbReference type="WBParaSite" id="TTAC_0000944901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000944901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000944901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000944901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12863" checksum="4F3C18F64DB8B34C" modified="2016-06-08" version="2">MPYQCEVLTNCLETVQIYLHAGGRGLKRSFFQRSPELYNLQQALALYSQTTDALLKDYVTTEVFIMAVVLFLLLLDVFPVVAIFRNRKNQNLLTVYLSNVVFRAFPVSILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7D0</accession>
    <name>A0A0R3X7D0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9436</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020817">
        <property type="protein sequence ID" value="VDM34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7D0"/>
    <dbReference type="STRING" id="6205.A0A0R3X7D0"/>
    <dbReference type="WBParaSite" id="TTAC_0000945501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000945501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000945501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000945501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125302" checksum="AAF2F97EC55818F0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7F1</accession>
    <name>A0A0R3X7F1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9461</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020830">
        <property type="protein sequence ID" value="VDM34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7F1"/>
    <dbReference type="WBParaSite" id="TTAC_0000947601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000947601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000947601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000947601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32795" checksum="07711552A8E21512" modified="2016-01-20" version="1">MDLKGGILDPVSNFDDDVPVSLTFKVQTAQRSKSEKEANSFIQTTRQKARARRRARQMVEYPRRYSTSVYSIEKAVEGTVKSNVAAIETSTLLPKLELSKSKTKRNCIADSRGNEDEFGLMDTFDFRKYLPQNFLGGGAEDMNSFDENDAYLGFEEKELGNAILKGGFAKDPEESCHGTEEQDEKMILKKKQSVILSKTPGVTGLGSIMKKRLLGSRHNRKQNYATQRIVILSQQDTASLIHQRADAFVNQRLFDTVLGVGKPFRTPSRMSPQDVSRMAAKLKARKLARQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7U9</accession>
    <name>A0A0R3X7U9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020924">
        <property type="protein sequence ID" value="VDM34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7U9"/>
    <dbReference type="WBParaSite" id="TTAC_0000962401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000962401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000962401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000962401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14571" checksum="5FC8D65ACBCF6C52" modified="2016-01-20" version="1">MMMFGVCEKKHVKCLDLVEIADEEDEDDDEDDERERDEEEDEEEDDDDDDLECYKSRKMILQLTLPLHFLEHEPDLELDLEELEDLDLEQDESEASDRALLEQLLDDPDESVVREEGTSSIMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Y3</accession>
    <name>A0A0R3X7Y3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9643</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020954">
        <property type="protein sequence ID" value="VDM34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Y3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Y3"/>
    <dbReference type="WBParaSite" id="TTAC_0000965801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000965801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000965801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="931"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="117"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="281"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="385"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="513"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="618"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="745"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000965801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112054" checksum="57CA2FCD1F76DC70" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X865</accession>
    <name>A0A0R3X865_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9725</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021007">
        <property type="protein sequence ID" value="VDM34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X865"/>
    <dbReference type="STRING" id="6205.A0A0R3X865"/>
    <dbReference type="WBParaSite" id="TTAC_0000974001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000974001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000974001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="258"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000974001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="612" mass="68082" checksum="811DA7BDF6496E99" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8X2</accession>
    <name>A0A0R3X8X2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D</fullName>
            <ecNumber evidence="2">3.1.4.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9982</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45528"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85277"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:45529"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 zinc divalent cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPE-PLD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.54" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01021212">
        <property type="protein sequence ID" value="VDM34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8X2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8X2"/>
    <dbReference type="WBParaSite" id="TTAC_0000999701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000999701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000999701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0595">Phospholipid degradation</keyword>
    <keyword evidence="3" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000999701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40420" checksum="56E08BCCE40A6064" modified="2016-01-20" version="1">METAGRVIPIKHNRWGRYVNPWDSWNEKRIKAAYYLLTNKPSEDIWPSPSNAELDINLPVVKPVFGPPFVGFDSDCGVRLTWLGHASVLLHLDGVNILCDPIFGSRCVVIGPKRYRPMPCKVDELPKIHAVVISHNHFDHLDLPTIRELSQCFPDTIWCVPIGCADLVASTIDRGKERRRPRIWEAMWWEERTIGHSGLRLIFTPAQHWSGRNIFFDNDKSLWGSWTFVGPTHRAWFAGDTGYCEVFQDIGERYGPIDVAAIPIGAYTPRNLMRPQHVDPQEAVQIHRDIRATHSVGVHWGTFHIGREPYMQPKDDLKAALDAAGLTEEDFRTLYHGQSLCYRRIPNETLMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H0</accession>
    <name>A0A0R3X9H0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021395">
        <property type="protein sequence ID" value="VDM35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9H0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9H0"/>
    <dbReference type="WBParaSite" id="TTAC_0001019501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001019501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001019501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001019501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25816" checksum="099882FCE7FB738C" modified="2016-01-20" version="1">MSYYVDIATSVGESAKEQAALVREAFQLCLNIMQMSRKYSKPSPLEMAKIMQPLSFKLFEIAEVANRNKSHIFYQPLLTISDSVSILSWINMSCSAIFVKDVENATKVSANSTTQMYRESMPLYAEWMRAWLRVIGSLRELVCDFYPVGLIWQPSGFAQPPPAPPRISAPMHLELNSDGASITSNTSSRPEWKRKDGGKIFNRDALLNDIVRTRLVHLKHVEGFSYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H1</accession>
    <name>A0A0R3X9H1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10181</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021396">
        <property type="protein sequence ID" value="VDM35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9H1"/>
    <dbReference type="STRING" id="6205.A0A0R3X9H1"/>
    <dbReference type="WBParaSite" id="TTAC_0001019601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001019601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001019601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275922at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001019601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25008" checksum="67BEF85BBF461ACD" modified="2016-01-20" version="1">MGGNIGKPTSSKESTEKTEFPPNFNQQSDDISTGGECAKPVSVVEKQMVPVTQNFENSTLMEQCIMIVLYDFAATLDSQLTVKRGEIVRLLGYSPAGDWSEVEAPSHLPNRTPRVPWAGAGGWVRGWVPTSYLTEHVRSQHVGGICGNTAEWRRVGDEEEATAAAATTTYPWYHGAVSRQAAEQLLRSGITGSYLVRESESAPGQLSVTVRNLGRVYHYRISRDSCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9M2</accession>
    <name>A0A0R3X9M2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10232</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021453">
        <property type="protein sequence ID" value="VDM35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9M2"/>
    <dbReference type="WBParaSite" id="TTAC_0001024701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001024701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001024701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001024701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20566" checksum="FF7BF5827A80BEA1" modified="2016-01-20" version="1">MAEVMTEEWREEISPSQINLFYSGKVAEGVLIERHRDHGEGQIDSITTLETSTSTPSVSTASMEGSNQPNLKLSTNVMKDCCWDVQTEERDDEEEEEEEEKEKEEDEEEEEKNDEEEERDDEEEKEEEEEEKEEEEEEERDDEEEEKEEKEKEEDEEEEKKNDEEEEKEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAW8</accession>
    <name>A0A0R3XAW8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Skp1_POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10678</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022032">
        <property type="protein sequence ID" value="VDM35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAW8"/>
    <dbReference type="WBParaSite" id="TTAC_0001069501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001069501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001069501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10548453at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001069501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12308" checksum="2C02E975A26BE71F" modified="2016-01-20" version="1">MEDVNSNTETGETVSIAPLQQSDQSTSNATFLTSAVGRLIASEGDAFRHLQIPCSVVCTISDRLTPLIVAYSQSIRDDCPSTHPSEVESADSEIRDWRAAFDAEFRASIVKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBC2</accession>
    <name>A0A0R3XBC2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10832</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01022326">
        <property type="protein sequence ID" value="VDM35812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBC2"/>
    <dbReference type="STRING" id="6205.A0A0R3XBC2"/>
    <dbReference type="WBParaSite" id="TTAC_0001084901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001084901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001084901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275030at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF28">
        <property type="entry name" value="UBIQUITIN THIOESTERASE ZRANB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="177"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001084901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34571" checksum="B9AC5E352395C819" modified="2016-01-20" version="1">AVITGDSDVLKKFILTAESLSLLSSHQLTSQDCQLLEQWSSGESNFLKPGLSLLDLARAYNRTEWVSSLSAFCPTNPQTRPSAKRSVCQSSGCAAKELRRLLDSCVRQRKGTFHCSYLTEFSTFYLPREVRDFPCSVQEVIIKELCDTEVQNELEVRSQAINWWVVEGQQNQPTSRLLALWNRTDGDCLLDSLMQACWGVFDQQSTLRHALAGSIRACEGQFYRVWREHEVHQAASQYQPDEEQLLRDWQSALTAASLTRSPLEQIHIFVLAHVLRRPIIVYSVKYIHNYRDEPIGLANFEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBV2</accession>
    <name>A0A0R3XBV2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11012</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01022738">
        <property type="protein sequence ID" value="VDM35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBV2"/>
    <dbReference type="STRING" id="6205.A0A0R3XBV2"/>
    <dbReference type="WBParaSite" id="TTAC_0001102901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001102901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001102901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="105"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001102901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37066" checksum="62AF9B1F5839B22F" modified="2016-01-20" version="1">MSSRVATQFVKSHLVEVVPYNYVFMAFCKRRWIGCRLLDVLDKEFNFDEMDIIVQRISSGQIKVNGDKVSTDYILQDSDLLEHSVHRHELPILDKSIDIVFEDDDILVVNKPPSMPIHPCGQYHHNSLVKILHNEMGMKNLRAVHRLDRMTSGLVLIGKTYEAATKISCQISDRQVSKFYIAEVEGQFKGSTEAGAEKSITPTPVVVDQPLGRLNSRLGLNAVIPESEGGKPAKTAFVPLLWKKPKDADDPGSTIVLCRLYTGRTHQVRIHLQYLGFPIVDDPLYNSYDWGESKGAFAKYREPRAELIAALAATHNRSTYLKTAEVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCD8</accession>
    <name>A0A0R3XCD8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PI3K/PI4K domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11198</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023186">
        <property type="protein sequence ID" value="VDM36178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCD8"/>
    <dbReference type="STRING" id="6205.A0A0R3XCD8"/>
    <dbReference type="WBParaSite" id="TTAC_0001121501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001121501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001121501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF111">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE AGE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="58"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001121501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48214" checksum="F47D1DBBACFF378C" modified="2016-01-20" version="1">MLANLLAEAIRLYGLYRVAEDEEQRTRFKFELHRSEVRGDLENILSPLRFSIKLGPVVEQQCTVKRSKKRPLWIAWANPDNLASHHHMIHQLLFKHGDDLRQDMLTLQILKVMDHIWKEEGFNLDLTTYDCLATGDEMGLIEVVRNSQTIMSIQGQRVRSAMQIDSSQLHKWFLQKKAAPLGSEEAYEAAIRRFTNSCAGYCVATFVLGIRDRHNDNIMVDDSGRLFHIDFGHILNNKKKKFGITRERVPFVLTSDFACVIARAATAQWPSQWFIHNFSACYSSSSPPPLLSLAYIFAAHVAYIALETGSPLRVGVGSNLKWEEKPYRSKGFMDFTRLCGDAYRILRQHSNLLLTLLAMMVPSGLPELTCAGDLEYVRKTLAVELHDEEEALNYFNAKFNEAYNGAWTTKIDWFAHWVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD69</accession>
    <name>A0A0R3XD69_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11478</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024375">
        <property type="protein sequence ID" value="VDM36617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD69"/>
    <dbReference type="STRING" id="6205.A0A0R3XD69"/>
    <dbReference type="WBParaSite" id="TTAC_0001149601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001149601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001149601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001149601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14872" checksum="43A36A5CCD246A9E" modified="2016-01-20" version="1">IKNKFPPLLEPGFANKARLCGNVRNLDQTGDQRQPQQPPTADKKPEKTINKRLQRTQAQVNEVVDIMRVNIEKVLERDKNLSQLDDRAGETFNASFITIFWSCLCKSMKNSSPTGSLSKTRCRIFFFQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDD7</accession>
    <name>A0A0R3XDD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024897">
        <property type="protein sequence ID" value="VDM36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XDD7"/>
    <dbReference type="WBParaSite" id="TTAC_0001156401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001156401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001156401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001156401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="27807" checksum="83C26B18AB292B9F" modified="2016-01-20" version="1">MRLIFTNGERGLVGPRGPAGPSGPRGLTGLPGPQGPIGPVGLQGADGTMGPMGPPGPRGPPGSVGMTGPVGLKGDVGEVGPVGPMGEPGEAGADGAPGAPGEAGEMGPPGKDGAVGGKGEQGPPGPVGAPGLAGPRGPPGRAGFQGTPGPRGEQGPPGPQGPAGAPGPAGSIGDAGERGRVGRPGDVGKQGLRGPPGPTGERGDIGSPGAPGIPGTPGKLTLLICTFLNGSASSQIKFSAIKISKLXXXXGIPGTPGKLTLLICTFLNGSTSSQIKFSAIKISKLVLWPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD98</accession>
    <name>A0A158RD98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1394 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS172</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000011">
        <property type="protein sequence ID" value="VDM16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD98"/>
    <dbReference type="STRING" id="6205.A0A158RD98"/>
    <dbReference type="WBParaSite" id="TTAC_0000017101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000017101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000017101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60973at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000017101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37885" checksum="5514A60CD41AFD71" modified="2016-06-08" version="1">MGNIIRLLTSRFEEIKDDVDIFVDFENCQPSDEEYDLWIEINTKLAHADDILTIVRNYPGAAAQIRNAIEHYTDDAAQEAAWEALIPLVHQLRICYDFGVYLGSLFGLKTSRIPAGRVYLLQRAQTVPRLLHALCSDELTVWEHLESQQALFKQFAEILDFIMQFDNLKMTKPSIQNDFSFYRRLRQRRRPVVDFTQQVVTPCDVGDAESLRQEIEQISDECCSKMSLFYAEATPMLKLISRYATQCHMVDAMTPMDVTSECLAAMAHICRGLLVKPSLRSRVTRDDTLMLLLRVMTGVIILYDHIDPYGVFRKTSKLDVSVLLAGTASSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDB4</accession>
    <name>A0A158RDB4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS271</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDB4"/>
    <dbReference type="STRING" id="6205.A0A158RDB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000027001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000027001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000027001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="330"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000027001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="702" mass="78466" checksum="65E538C24E9C5EBD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDW4</accession>
    <name>A0A158RDW4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tub domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6197</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDW4"/>
    <dbReference type="STRING" id="6205.A0A158RDW4"/>
    <dbReference type="WBParaSite" id="TTAC_0000621201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000621201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000621201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="530"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="760"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000621201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="804" mass="88799" checksum="2C9B8FD1EAE09309" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REZ4</accession>
    <name>A0A158REZ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Syntaxin binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8426</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020503">
        <property type="protein sequence ID" value="VDM32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REZ4"/>
    <dbReference type="STRING" id="6205.A0A158REZ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000844101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000844101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000844101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000844101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="652" mass="72265" checksum="8E2BA8591CE134FF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF05</accession>
    <name>A0A158RF05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8488</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020515">
        <property type="protein sequence ID" value="VDM33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF05"/>
    <dbReference type="STRING" id="6205.A0A158RF05"/>
    <dbReference type="WBParaSite" id="TTAC_0000850301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000850301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000850301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000850301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56720" checksum="BB2313456E510197" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF28</accession>
    <name>A0A158RF28_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8653</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 13"/>
    <dbReference type="EMBL" id="UYWX01020556">
        <property type="protein sequence ID" value="VDM33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF28"/>
    <dbReference type="STRING" id="6205.A0A158RF28"/>
    <dbReference type="WBParaSite" id="TTAC_0000866801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000866801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000866801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="3 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="27"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="14">
        <location>
            <begin position="373"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="345"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000866801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="493" mass="52184" checksum="F9A9730E4167CB5A" modified="2016-06-08" version="1">MFRLVSSGFFSKPVNFRLTRSLSSGEKDLVVIGSGPGGYVAAIKAAQLGMKTVCVEKYPTFGGTCLNVGCIPSKSLLASSHYYEMCKLNHLESRGIELSGVNLNLAGMMAAKVKTVATLTGGIVHLFKANQVESVQGVGSITKPNEVTVTKPDGSTEVINTKNILIATGSDVTQFPGINIDEKHFITSTGALSLGKVPEHLVIIGAGVIGVEMGSVWKRLGAKVTVVEYLDHIGGMGIDMEISKLFAKVLTKQGLNFKLNTKVISAELNDNCITVAVEGVKDGKSDSISCDTLLVAIGRSPYTTGLGLENVGIECDKYGRVPVNNRFQTTVPNIYAIGDVIEGPMLAHKAEDEGILCVEGMCGGNVHIDYGCIPSVIYTNPECAWVGKSEEDLKASGTEYKVGRFPISANSRARCNHESDGIFKVLADKATDKILGIHLLGPQASELIGEGVLAMEYGASAEDVARVCHAHPTVSEALREANLAASFGKAINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RFA7</accession>
    <name>A0A158RFA7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9355</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020776">
        <property type="protein sequence ID" value="VDM34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RFA7"/>
    <dbReference type="STRING" id="6205.A0A158RFA7"/>
    <dbReference type="WBParaSite" id="TTAC_0000937001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000937001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000937001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="129"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000937001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="982" mass="110853" checksum="5F0ED73B3354E657" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EHL6</accession>
    <name>A0A3P7EHL6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wntless-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002374">
        <property type="protein sequence ID" value="VDM22550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EHL6"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="6">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="196" mass="21623" checksum="79CDA5D243363885" modified="2019-02-13" version="1">MNCAAYTFKVRFFGLHPQNIGKLGDAGSVAHNADELQEASSELRAEEAGAVKPHIPTFEITEIEFITQTHNTTFSYFELLSRFVAFLAAFGLLAGFCLSMRSFEWKYWTAEQKWTVVLLVLLLFFYSEFDLNGFACTASSLLVIKIPSTPLSEVIACCRSAPPTGISSARLDSTGSGRLFSSLLLRLSTPLLAVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EHY9</accession>
    <name>A0A3P7EHY9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002329">
        <property type="protein sequence ID" value="VDM22491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EHY9"/>
    <dbReference type="OrthoDB" id="10262769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037912">
        <property type="entry name" value="MCRS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025999">
        <property type="entry name" value="MCRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233:SF0">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13325">
        <property type="entry name" value="MCRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="434" mass="49048" checksum="CD748C74D82A6E75" modified="2019-02-13" version="1">MAEVCACVRFTRSYTESEVEQRWRLLLFNPAVSKTSREAIFHLPQIVKCRLDAQIPFSGEEDALLMTISYNDVYKENLDKYFVFERLLNDHSRVFYSTRTPSHLYSQWNRLRSCRLISEEGLDKGSDIGGDPESFSDTEFIIQETTARVMQAGLPHLMESSNIARRKRLLASAVTYHGFQASVSQAVADSLVKYRRSHSFCASSSSGTNRVLPRSPSWAGFRSESIGVEQSDFSNSGQEELVPEIQLERYRARRRLHAKMARVEEEARRWTALVESKVANGIIISDHQPIYPTLATLTGRRSRFLIKCKNVTFGRTVHNFAPDIDLSREGEASRISRRHGKISLADNGVFWLTNLSKHPVLVDGTPVLKDKKYQLSDKSIVCISHLSLRFDVEHEHISMLSGLTNVAAVGDLESPLPRGRNQTDVHGQAMDKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EIQ3</accession>
    <name>A0A3P7EIQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002690">
        <property type="protein sequence ID" value="VDM22930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EIQ3"/>
    <dbReference type="OrthoDB" id="6261165at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="315" mass="36646" checksum="7860907B1E1BC0F4" modified="2019-02-13" version="1" fragment="single">MEIANGTRIQFPIEMSLPWILTDHILETHDPALMESLLYPLDLYNDAADCALNRFHRRFFFDEIEAEANLVFDQLVYKLSDQLFRYYKQYAASILLDKKFRMEAQKAGWREPYPQPNRYAAALIRQRSVQLLGRSIDLSYLLSQRINRAITKSLEEAIQRFLCSDITAVVELEALIECNRLCHRMLAEYLELDDFDGMLQEANNLVTSPLSKIAFHVFWEVTWDLVKNYCYNGSTNRFVQTKFALAETLEREKPSPCAPEYLWGSKSLNSCYEAIFQLCRGFIGAPHFSAICRLLGYQGIFIIFTEIMKFCKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQD0</accession>
    <name>A0A3P7EQD0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000643">
        <property type="protein sequence ID" value="VDM18704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQD0"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="3">
        <location>
            <begin position="885"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117064" checksum="15570835803F40FF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EYJ0</accession>
    <name>A0A3P7EYJ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004655">
        <property type="protein sequence ID" value="VDM25106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EYJ0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="140" mass="15671" checksum="3BC1788D036198E1" modified="2019-02-13" version="1">MDDPLLLDEALTFSEFFGQFRRVCIAATEECPLHRDTSWEGSMARGSLDETLHICNESGQTADDSREADSGVGNRLTFPLDHVVDPSHEDVPTFSCLNIWLQFFVIHTAILAFGIPPKTWRGEVQAHPVQLLPDSVIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FAX8</accession>
    <name>A0A3P7FAX8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005450">
        <property type="protein sequence ID" value="VDM25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FAX8"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28371" checksum="EFF28420C9B4AE72" modified="2019-02-13" version="1">MNFLVEEMKNPGRNLPLAIGIALTLVMGLYVLTNIAYLAVLSPYEMLATGSGSSAIAVVFAERAMPWISMLMPVFVGASVFGSINGEAMSMSRLTYTGAREGHMPSILAMIHHCNLTPIPAILILLVLAVGYQFYSDLFALIELAGFAFSFIAALAVTALLYMRYKEPDLKTSFQLPIFFPILFLGCDLFILVLTIYQQPRESFSNVVLMLAAVPIYWLGVSWKKKPKSFQNFINKGTVFLQKVFACVPVEDESQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFF9</accession>
    <name>A0A3P7FFF9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008853">
        <property type="protein sequence ID" value="VDM27584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFF9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="211" mass="22834" checksum="EEF22CDFE435C7DF" modified="2019-02-13" version="1">MRSEAVEVARELAFSNSQVEAEWRRWRDTRVLETTESLTALTGAYVVYWNAVAEAWRDAAALLKAPVSSRQFSMEGSIMEASPQVASHYATSESAEDLWNVVGCNTDVKEGEIENKREQEWPHADLWESSLRSPSPSVKSGGVDVRNGEAVGEVLNCSQSNTSTDEAEGGREGRTAGNPSNCNSLENSAEGGVKERGWSDCGGAEDSGKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FMV4</accession>
    <name>A0A3P7FMV4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FMV4"/>
    <dbReference type="OrthoDB" id="6140671at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018135175" description="MARVEL domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24843" checksum="C5A6EE568C9268C2" modified="2019-02-13" version="1">MISVLILILYFLLYGQPAAESTIVCGLQIFIGLLLSISLIVFGVNSQNRKWMQRPDHMFLSWSFGFLILATISSFISAAFLCCVSYTDRAAQREVEHYEAIEGQFGARSLAAGTYLTGPQPSALFTRSIFGSQPRMVGGVVVSVPAPGDEPTQTVEIGNTNIYSGRGSTGNQLSPLREEPLTDDGTFGDGDSGTYASSGNTNAHQPPSWRQHPTSATSPNSMLYAYRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GDG8</accession>
    <name>A0A3P7GDG8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001234">
        <property type="protein sequence ID" value="VDM20532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GDG8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="78" mass="9046" checksum="2B3D2782D8334C22" modified="2019-02-13" version="1">MACIPQLPLAYAASAFLRLMFKKYSTCSTSTRLRSGHLLDRGMSNDDEPWKVFVISKDHFVLLICEDFVYFIPEKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GEE1</accession>
    <name>A0A3P7GEE1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="6">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01001053">
        <property type="protein sequence ID" value="VDM19965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GEE1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM19965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="968" mass="107450" checksum="28F45E96DEC40093" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GRM7</accession>
    <name>A0A3P7GRM7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004177">
        <property type="protein sequence ID" value="VDM24702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GRM7"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053260">
        <property type="entry name" value="hnRNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48035">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48035:SF2">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="149"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="242"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="318" mass="34878" checksum="C3AE4FC3C657D734" modified="2019-02-13" version="1">MPFPRLPLPSPRVDIGSQSRGVTSTNLGAGKSRVKLYVGGLRLDHTEAQLRQYFARYGALTECYVARDFKTKASRCYAFVTFREEAHASRALADCPHFIEGDPVSVRPFNLKTKEKMVIPSAVDKDATKVENAGEGGAAAGGRPKVHELCLRVARLELSTTQQDLSDYFSQYGPIASVNLTPGVGGKVPGGTALVHMRTPQGVEAVLRACPHQLCGKEIFVTPAFSRTSRRVSSRRGKETGHRVVVHDLPLQASAERIKSVFDRFGKVECLTVNKAARKAFVHYASMEAVKRVMAATPLRLEDVDLRVSLTDVLDWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HCC5</accession>
    <name>A0A3P7HCC5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020379">
        <property type="protein sequence ID" value="VDM31915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HCC5"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="140" mass="15250" checksum="4EF1CE9FB2B3C9D0" modified="2019-02-13" version="1">MAVRRKKTTIFLSLKENAEVLEVKQMIEGILKVPPEDQVLLYGSTAMYDHKSLSYYGLTDLTARAHNPAILGLCLRDSESGQFEPLDITPYSKPPELPEVMRCQENQPPRNTSAAGVSAANTTTAANSANQAETTAASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HIU2</accession>
    <name>A0A3P7HIU2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021366">
        <property type="protein sequence ID" value="VDM35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HIU2"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="232" mass="26978" checksum="6C0FC46AB10C86DC" modified="2019-02-13" version="1" fragment="single">MFSFSAVFAKLPQFSYPAFRLFRGSFLVIYYVCMVGVNVYGWRSSGVNHVLIFEIDPRSHLNQFQLMEMGMFLADFWGAAVLLYQFSDLIHFPGYVTPLVLFLTMLVFLLLPFHVFHFKSRFWLLKILVTPLARVHFPDFFLADQLNSLSFILPDLAYFLCFFVNFIDNQMMIKSSLRNSTIPPPGASQLFGHSTTLLQTFFQSLFESTQMLVNCGRHLKYGVKKAKFFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HM36</accession>
    <name>A0A3P7HM36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022235">
        <property type="protein sequence ID" value="VDM35762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HM36"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="34" mass="4125" checksum="C9EA46F84EDDC856" modified="2019-02-13" version="1">MIEREQRSVRHFSSRSKQLDKRRHKTVAMSNVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HNQ5</accession>
    <name>A0A3P7HNQ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022822">
        <property type="protein sequence ID" value="VDM36035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HNQ5"/>
    <dbReference type="OrthoDB" id="840771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="176" mass="19773" checksum="897AC6056FD78FE4" modified="2019-02-13" version="1">MSKLHDLGWIHRAICARHLLLHSSSENNEDSLDVSFCGLGSIAPAKPFGSVLNRTDLPVIDAKWRGWHYQNLQENVYSTHPVAWYSPEMISQDFEGYGKPSDIYSLGMTLAEIRDYPFVTPPGRAASGEMLNIFESCTHPDPNCRPTAEDLINTPWIQNGLTTPLRESVLASFRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHK8</accession>
    <name>A0A0R3WHK8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS30</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000002">
        <property type="protein sequence ID" value="VDM15645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHK8"/>
    <dbReference type="STRING" id="6205.A0A0R3WHK8"/>
    <dbReference type="WBParaSite" id="TTAC_0000002901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000002901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000002901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF147">
        <property type="entry name" value="CGMP-DEPENDENT SERINE_THREONIN PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="9" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="266"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="384"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="627"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="924"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM15645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000002901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="993" mass="109969" checksum="2C3E56FE32E1B3E4" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHU5</accession>
    <name>A0A0R3WHU5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heterogeneous nuclear ribonucleoproteins A2/B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS134</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000009">
        <property type="protein sequence ID" value="VDM15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHU5"/>
    <dbReference type="STRING" id="6205.A0A0R3WHU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000013301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000013301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000013301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF14">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000013301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36834" checksum="FD2C257F1CA2A16E" modified="2016-01-20" version="1">MYNRYSENNDSRTEQYRKLFIGGLTHNTTEDHLKEYYSAWGEIVDVVVMKDSQSGRSRGFGFVTYKEPEMVDTAQANRPHEIDGKIVEAKRAMPREDSSCAEAHMTVKKLYVGGLKRDVTTEDLREYFSKYGKIVDCEVVTSKDTNISRGFGFVTFDDYDPVDKAILYKPHTIKSSQSDVRKALSREEMNTIRRKTDYRQDYGYGGGYRNGGYGPPGNYSGYLHHGYAGPPPGPMGGYHDNWDPYPPNGCWNNGMGDGFGHYGGQSYGGGPMRGPPGGGYQLVVSEGALISMSLNRRECIATYTDPLYSFRIHLPFIQLVLSPIVLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI48</accession>
    <name>A0A0R3WI48_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS250</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000017">
        <property type="protein sequence ID" value="VDM16147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI48"/>
    <dbReference type="STRING" id="6205.A0A0R3WI48"/>
    <dbReference type="WBParaSite" id="TTAC_0000024901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000024901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000024901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000024901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="864" mass="100753" checksum="1F69C9BFB0A16BA3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ13</accession>
    <name>A0A0R3WJ13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAP10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000070">
        <property type="protein sequence ID" value="VDM16773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ13"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ13"/>
    <dbReference type="WBParaSite" id="TTAC_0000063401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000063401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000063401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235876at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000063401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16330" checksum="281B8AC93F90D464" modified="2016-01-20" version="1">MADKAKWTRSLHYNNQSFSLNIEVNDRPSHWIINYIFEILIRERFGYRNINFIYTPWDSSLDAINRLNCEKSNDCSRPPPIHVNLELWLRTGEQVSDHAPSHRVNMNGPLGPITRWGLYTNEELLTRQSPVCFYFPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJI6</accession>
    <name>A0A0R3WJI6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS836</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000109">
        <property type="protein sequence ID" value="VDM17056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJI6"/>
    <dbReference type="STRING" id="6205.A0A0R3WJI6"/>
    <dbReference type="WBParaSite" id="TTAC_0000083501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000083501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000083501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF48">
        <property type="entry name" value="DNA HELICASE MCM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="8">
        <location>
            <begin position="340"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000083501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="906" mass="99708" checksum="63F4E27F9E88C019" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKZ2</accession>
    <name>A0A0R3WKZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1406</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000300">
        <property type="protein sequence ID" value="VDM17946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WKZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000141901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000141901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000141901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8123449at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000141901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56932" checksum="C7DDEDC1DE44A640" modified="2016-01-20" version="1">MADEIDVEAMLEAPFEKGNSALDKSGSSRHRDRSRSRSRDRGRRHRDRSSERRRDRDEFRSERRRERDRDRRDRDRDRNRDYDRRRDRDYDRPRYERSRRDEFPPEREREDSDDKGPKRFYRNGEPRPRSPELSPEERDARTVFVWQLSARIRQRDLEDFFSSVGKIRDVRLIIDGKTKRSKGIAYVEFREVESAQLALGLTGTKLLGVPIQIQQSHAEKNRAANAGGSAMAAAYGRPVSSRGPMKLYVGSLHFNITEEMLRGIFEPFGKLDDIKLIKDPQTNRSQGYGFVTYSNGDDARKALDQLNGFDLAGRAMKVNYVTERSDYANLSALDNEEADRTGVDLGTTGRLALMAKLAEGTGLEMPKAALAQLQGNPTLGIAGKVSSSSAVAPPVCTQCFMLSNMFDPHVASHTTFEEIKDDVISECSLLGGVLHIFVDQTSAQGNVYVKCPSIAIATQCVNKLHGRYFSGRLVTAAYVPLITYNQLFPDSVTAKTILKPTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL07</accession>
    <name>A0A0R3WL07_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS1424</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000306">
        <property type="protein sequence ID" value="VDM17972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL07"/>
    <dbReference type="STRING" id="6205.A0A0R3WL07"/>
    <dbReference type="WBParaSite" id="TTAC_0000143701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000143701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000143701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000143701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50411" checksum="467AD69C64A54546" modified="2016-01-20" version="1">MRELVHMQAGQCGNQIGSKFWETISQEHGIDDKGAYHGDSDLQLERINVYYNEGQGGKYVPRALLIDLEPGTMDSVRSGPLGKLFRPDNFIFGQSGAGNNWAKGHYTEGAELIEEVLDVVRKECEACDCLQGFQLCHSLGGGTGSGMGTLLIAKIREEYPDRIMTSFSVVPSPKVSDTVVEPYNATLSVHQLVESTDETFCIDNEALYDICFRTLKLPNPNYSDLNHLVSLTMSGVTTSLRFPGQLNSDLRKLAVNMVPFPRLHFFVPGFAPLASRTSQSYQSCTILELTRQMFDAKNMMAACDPSHGRYLTVAAMYRGRVSMKEVEDRILETQTRNSTYFVEWIPNNVKTAVCDIPPIGFKVSGTFIGNTTAIQELFTRVSDQFAAMFRRRAFLHFFTSEGMDEMEFSEAESNMNDLISEYQQYQEVGIDDDYGEEGETAEEEAPLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL25</accession>
    <name>A0A0R3WL25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBM21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1446</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000318">
        <property type="protein sequence ID" value="VDM18006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL25"/>
    <dbReference type="STRING" id="6205.A0A0R3WL25"/>
    <dbReference type="WBParaSite" id="TTAC_0000145901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000145901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000145901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF48">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="420"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000145901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="624" mass="69292" checksum="9A001FB21211CE11" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLZ6</accession>
    <name>A0A0R3WLZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1771</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000500">
        <property type="protein sequence ID" value="VDM18511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000178401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000178401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000178401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000178401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12871" checksum="25796DC837CF37E8" modified="2016-01-20" version="1">MLAWPHSRVVRNGGRTDANLLAKRIVVRLIVGFRALHIRPRDLFHPQLSAPRTELDAVAMPLNLFSSHKHANVIESFFTGLSTSYIVQQEEEDEEEVLPPLGGRISSSDIDPSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM07</accession>
    <name>A0A0R3WM07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1782</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000506">
        <property type="protein sequence ID" value="VDM18522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM07"/>
    <dbReference type="STRING" id="6205.A0A0R3WM07"/>
    <dbReference type="WBParaSite" id="TTAC_0000179501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000179501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000179501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000179501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12419" checksum="FA26E2CD0B0C469C" modified="2016-01-20" version="1">MIVAGEYVDLTLATLFGFSTMAAAGIGNLISDLCGLGLVGYVERYARLFGVKAPSLTESQMNSKSVRRCSNLGRMFGITVGCLVGMLPLLLFPYEEDEKARTKEEEGRKEESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM21</accession>
    <name>A0A0R3WM21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1796</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000516">
        <property type="protein sequence ID" value="VDM18536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM21"/>
    <dbReference type="STRING" id="6205.A0A0R3WM21"/>
    <dbReference type="WBParaSite" id="TTAC_0000180901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000180901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000180901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000016">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="62"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="310"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000180901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43552" checksum="67F59379C62AEFFB" modified="2016-01-20" version="1">MGILDKIAEVEREIARTQKNKATEYHLGLLKAKLAKYRAELLKPVDKSQKGEGFDVLKSGDARVVLIGFPSVGKSTLLNALTSANSECAAYEFTTLTCVPGVIEYEGAKIQLLDLPGIVEGAAQGKGRGRQVIAVARTADLVLMMIDATKPLIQRELLEKELESVGIRLNQRKPNVYFKVLSKEGWRNANQLNVFTYTYQREDGADDFTRVQYPFDIPYGYALMQHYSLASVEIFNADVVIREDITQDQLIDVIVGNRVYLKCIYVYNKIDQISLEEVDKLAREPHSVVISCNLNLNLDYLLKVLWKYLDLIQIYTKKQGQKPDLDEGIILRNGATIEHVCHCIHRSLASNFKYALVWGTSVKFSPQRVGLSHVVNHHDVIQIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM66</accession>
    <name>A0A0R3WM66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3_10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1841</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000547">
        <property type="protein sequence ID" value="VDM18581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM66"/>
    <dbReference type="STRING" id="6205.A0A0R3WM66"/>
    <dbReference type="WBParaSite" id="TTAC_0000185401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000185401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000185401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283009at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000185401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70519" checksum="80721BE8BECA4E2A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMR8</accession>
    <name>A0A0R3WMR8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-phase kinase-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2043</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000708">
        <property type="protein sequence ID" value="VDM18783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMR8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMR8"/>
    <dbReference type="WBParaSite" id="TTAC_0000205601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000205601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000205601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000018">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000205601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18759" checksum="31DF31F94FAAC850" modified="2016-01-20" version="1">MPVKLVTSDEVAFDVDLEIARQSVMIRDILDDVGPEAAEDDEPIPLQYVNAAIFKKVIQWCTYHKDDAPQQDDDENKERRTDDISSWDQEFLRVDQGTLFELILAANYLDIKGLLDTCCKSVANMIKGKTPEEIRKTFNIKSDFTPQEEEQVRKENEWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMU5</accession>
    <name>A0A0R3WMU5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2070</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000730">
        <property type="protein sequence ID" value="VDM18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMU5"/>
    <dbReference type="STRING" id="6205.A0A0R3WMU5"/>
    <dbReference type="WBParaSite" id="TTAC_0000208301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000208301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000208301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000208301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16910" checksum="3B19532C42D37E87" modified="2016-01-20" version="1">MVSARVQDSYQAWRNYVAFWCFGLFNNFNYVVMLSSAVDILGRGTAKGSDRDADWQDYFNCTGVGTGTVLLADIGPSLLLKLLAPFFIQRLHFHLKVSLSAFFSLSAFLIVSCSTSIALSLFVQLTLLVSGVVCASVSCGLGDVTFLTMVAFFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNZ3</accession>
    <name>A0A0R3WNZ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2468</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001114">
        <property type="protein sequence ID" value="VDM20128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNZ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000248101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6237547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM20128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29088" checksum="FFE306770AB6EB7C" modified="2016-01-20" version="1">MNAMVPQYASLSGARSRLTEEEFGPLQVNQFNQYGNVVTYRCFESYFYPDRSFEKYVECALKEGVSNVGEWRGYSGTLLPLPNSCQPVTCMYEDVRVKKAYNIQPDFTISFANGTMQKWRKLKPVPYPYLTTIRYLCQEGYETVTKTPDQNISCGQIGRWRPQIYGCISVDKNVTTSSTGRYVPPAIEAPSANQVGAVVIGIIVIFLVSLLLLDLTTLHRDIRWLFNNVRLQKRLWLAKRRLRKKKQEVKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPQ8</accession>
    <name>A0A0R3WPQ8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">TTAC_LOCUS2733</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001442">
        <property type="protein sequence ID" value="VDM21017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000274801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000274801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000274801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM21017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000274801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52849" checksum="F471B7BB03275D44" modified="2016-01-20" version="1">MHPVHIHRAKIGTAAAVPIQPPIQMGGSLRNGQKTGSVAILDDFGDQLNHTFTPLLILLLAGIAMTKVYFLHPIACDIPAIPGDEFRSFAESVCWSSGIIRMEKDDEIPDGEVEWEKLLGRSEIAFHQWMPFCLSIQAILFYLPHLIWKVLSTNSFGDNLIYLITRAVAAGRCEEQAARLKLVRACADHLYLLSRQHFSTSMSICSRVQDSLCSRQPCGSSCLMKRRMGNHSVICYLFVKVLYISNCAGQIFLTVRCLRPSPTYGSVFDGVSGRLLSFAHSRKEWEGSQLFPHKALCPVRIPHLGVQSQTYTAICALTMNVLNEKIYLFLCVWILGVLTVTTATTLSWMWRLLIRAHSNSYLRSFLYISLLSPPPFQSLGTMEVVEVAGGICQTAGLDGALVERFLTEVVGNDGNLMVRMLRRNAGDVVTGEIFVTWWRMFKAMEGRGEVEDDASEYAATSPRTYVGMQEPNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPU1</accession>
    <name>A0A0R3WPU1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2766</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP300 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001487">
        <property type="protein sequence ID" value="VDM21109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPU1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000278101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000278101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000278101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259249at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029416">
        <property type="entry name" value="CFAP300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14926">
        <property type="entry name" value="CFAP300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM21109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000278101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23615" checksum="0029DEE22A5040A7" modified="2016-01-20" version="1">MIPWFVKLLTLKKGFRVNYSFTVDPVFLLVDDCDVLISNVPCTLLSMDIFNRCIGTVAHKTGRIKSCFEEYYESLVISDCLERALYIQGSEFYDLFNEAEREEFLFRLFKHIVTGGELSQPNEDLRAYTNFVKNLYRDLVSVQKIHDSEKVRVVSLVYDVRAMSNNRTVYPSGKVHVNTFAYLIVDPVKRHVFALSHVYGVGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQP5</accession>
    <name>A0A0R3WQP5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01001883">
        <property type="protein sequence ID" value="VDM21891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQP5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQP5"/>
    <dbReference type="WBParaSite" id="TTAC_0000308501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000308501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000308501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="8">
        <location>
            <begin position="55"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="7">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM21891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000308501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39112" checksum="020392265E21C047" modified="2016-01-20" version="1">MKLSFLTTKNDLITSSMAHQEKHPCLKEKSERGECAQDPLWKPEGKVYSPGVVGLHEEIIDFVDYIGPSYEGCFLREIIISKVRDLVSSLWPECKVEVFGSFSTGLYLPTSDVDIVLFGKWAQLPLGTLERALKENNFATDIKVISKATVPIVKFTDADTGLHVDISFNVTNGVRTTKFVRMCLENYPCLRYLVLTLKQFLLLRELNEVCTGGLSSYALVLMCICFLQQNNMKNESINSINLGTLLLEFFEFYGIRFNYRRTGIKFSGNWSFISKMSSEVKNYYLFDRFLYIEDPLYPGHNVTGGSYASDMVLAAFKHAYLTLTGILRNNVKRARTMLSSILYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR46</accession>
    <name>A0A0R3WR46_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002088">
        <property type="protein sequence ID" value="VDM22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR46"/>
    <dbReference type="STRING" id="6205.A0A0R3WR46"/>
    <dbReference type="WBParaSite" id="TTAC_0000323601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000323601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000323601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288382at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000323601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33938" checksum="2B31866D67615784" modified="2016-01-20" version="1">MIRLRKLLSVFFHFSRIVFDRWIEIELLDPEAAQRSLAAAIWLRTSLDRLLQIKLEELRGRWLRCAEESGEDNLVEKMATDLAPSTDCSTHTSKRVSEWRRLQRLLCEHLAAFLGQQTSGLHTLRKLSAADSKNLFRVSSPDGNANALPSLPSSEFNVVRVNPEKGGFQVTAFLTINSLRADAPKAKLPHSVTADNIEDSQNLESEDEGNGGDDATTANLECLDLALRLHKQVALAQEAGRSSEFAQLREMEVPKKDESGECGSEFIDENQAVNRCEHCGERLPNKPSAADLLRHKKHCKGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRK2</accession>
    <name>A0A0R3WRK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-synt_His domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3378</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002336">
        <property type="protein sequence ID" value="VDM22501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRK2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000339201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000339201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000339201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="1">
        <location>
            <begin position="38"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000339201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21594" checksum="0A6C4790ABF3D529" modified="2016-01-20" version="1">MQSDHDATISEQQIQELGKKIASSEISEQSFVLKTPKGTRDRSPVQMRILEQVFGVIQDCFKRHDAVSIETPVFELKEVLTGKYGEESKLIYNLEDQGGELLSLRYDLTVPFARYVAMNKIMSIKRYQIGKVYRRDQPAMNRGRFREFYQCVSVFGLCVFLYHSSHYFVGIWKGPVCRYFDPGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSA2</accession>
    <name>A0A0R3WSA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002765">
        <property type="protein sequence ID" value="VDM23016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSA2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000364201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000364201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000364201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6299092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000364201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12236" checksum="7BFA988571773A99" modified="2016-01-20" version="1">MQASYPLLPVCPLQQIVGQSLHERYGAFAAREWDSPLHTAPFPEHTNTVGTVIPPVLNWKSRCCVDPWKGIAPVQVPESGERLVTSVVNQRHTVLFSPPQWKFSTSSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSN6</accession>
    <name>A0A0R3WSN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3761</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002995">
        <property type="protein sequence ID" value="VDM23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSN6"/>
    <dbReference type="STRING" id="6205.A0A0R3WSN6"/>
    <dbReference type="WBParaSite" id="TTAC_0000377601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000377601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000377601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF129">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000377601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="50753" checksum="4D6D030128E2C7DE" modified="2016-01-20" version="1">SKSNWIKVLRTSWVSPPKWRIIVASSQFHFGVTLRYRCSRNRWQHERIKWNFVLPLTLSAPLISAFVRQNDGGGDDHKDANSKSSLGMFSTVVCATNLSPERLAAIKSLNILSKVVEEVSPAVVSITAVGHLFQAHASTGSGFIVDDTGLVITNAHVVGYKQALKVSTPNGQEFGARVLALDVNSDLALIQILADAETLKNLPVLNLASGEQAIRPGDFVIALGSPLSLSNTVTAGVVSAVDRDLGNRTGLKYIQTDAIITFGNSGGPLVSLYGEAIGVNTMIADTGLSFAIPIDQVHRFLATAKEALAVEQEHRRQGRSYSTPESSPPPSPRSQRSKSWQWFGSGNDGAAAEQDDASVFVESGKRQTRYLGLVMRTLTPELVSELISLGHLRAGGSTDSAHCAGVYIQGVIRNSPAERAGIRPGDVIVAINGTKIINANEVAKIIEEDEVFSVTVLRNGEQVDISDVKPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSP4</accession>
    <name>A0A0R3WSP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CASP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3769</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003019">
        <property type="protein sequence ID" value="VDM23328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSP4"/>
    <dbReference type="STRING" id="6205.A0A0R3WSP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000378401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000378401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000378401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6282315at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000378401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22386" checksum="9577EC22C255C693" modified="2016-01-20" version="1">MLTTDLRPTDWAMKLRRFTPHSFIQRSALPCLWTINLAPHLTSKVGTTSVLVQLEPSLKSMQQTRSHSAGLKAFLTGKMQPQKVDGQWRVSSRVSSLLSPRGLNARVRTCCVRIISLVIVSPANLSRSSWAWLVLLSAFFCTAVIDGLILSFGLHVLEMMEADTFTLGDTNTTNISFSLYLLPGALLTGMHLYASKSSQVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSS6</accession>
    <name>A0A0R3WSS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3800</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003079">
        <property type="protein sequence ID" value="VDM23414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000381601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000381601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000381601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000381601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18502" checksum="324539D06CBE022B" modified="2016-01-20" version="1">MCLLFALQTGSFLVRDSVTQPGCWALSVRVPTHVNCAGITHYLIQHSKHGVKLKAFVCTIFYSQFQGLDKEWPSLEALITHLTVMPEMLPCPLRLPPTAHSGGVGSNHHHQASNPTFTEEEDDERDGVTRTEGIGEKVDEEYQRLSDFSSMLADMKPASVVPHLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSW1</accession>
    <name>A0A0R3WSW1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3837</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003129">
        <property type="protein sequence ID" value="VDM23518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSW1"/>
    <dbReference type="WBParaSite" id="TTAC_0000385101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000385101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000385101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274570at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132985" evidence="2">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000385101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13803" checksum="1DDBEB042910E11E" modified="2016-01-20" version="1">MDKHLKYLVALLVVVLFTCLTGGLQLECGHLFGTGCQSWRTGREMTGLVAAALVAFVMASIFAALFILKKNRWSSICEFIALAAGSILMLAAVAVYYNRSSILSPLMAAITMTLAIEIAIFLLIDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSW9</accession>
    <name>A0A0R3WSW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3844</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003139">
        <property type="protein sequence ID" value="VDM23538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSW9"/>
    <dbReference type="STRING" id="6205.A0A0R3WSW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000385901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000385901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000385901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000385901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10821" checksum="A6B8D70FCEDB60F5" modified="2016-01-20" version="1">MHADFHTGFLGERQAGKSTCGTAALLPPGRVDRLTGQAGGAASEISRARNAALERGEKLSHLDAQTQEMMEQSKNLSKTAAMLAAKYEKHDKWWGVWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTI1</accession>
    <name>A0A0R3WTI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003576">
        <property type="protein sequence ID" value="VDM24080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTI1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000407101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000407101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000407101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000407101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28306" checksum="39255AC1B6009B45" modified="2016-01-20" version="1">MDDLKLDDDDSDDEEEFFKGENDSGATDEGYTSSRQRNGKIDEGSSESADGGDDDDDTVTLAPDDDSDEIGADEENEDNEDGEEDAEEEEGEEDEMVRLGLRPKYIKCPEDDEFVAELERMTAEAIMPGAGVPAGPTATVTSTAISGTASLLPSLESLGVGAAAARKAAARSAAAQTQSTAENIIAALESTTPRIATSPLNGDLTGNMVMWSEFKDYLFNLMLMPRIFAPYIRTISWTPLGWFCIDVNILRSTFLKGALVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU19</accession>
    <name>A0A0R3WU19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FACT complex subunit SSRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003996">
        <property type="protein sequence ID" value="VDM24511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU19"/>
    <dbReference type="STRING" id="6205.A0A0R3WU19"/>
    <dbReference type="WBParaSite" id="TTAC_0000425901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000425901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000425901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000425901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15906" checksum="A1D54F17C956984F" modified="2016-01-20" version="1">MLAIWFKGEDSKVVLTARKTDFLFPVDLPFLNLSQCTQATLDNPSALLSLMLGSTNGFATRTNPEKVSKGIHTLFGKSKTQSSDGNVLQTPFIAGIGYKPVKVRSPVFIHIHSCLPPPTTLRERFELRFGVRVGSTPVDALLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVA1</accession>
    <name>A0A0R3WVA1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4676</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005045">
        <property type="protein sequence ID" value="VDM25422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVA1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000469101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000469101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000469101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064612at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000469101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20952" checksum="36D6214DB874CA82" modified="2016-01-20" version="1">MEEKAGNLSTELTTLSNENAKLTAVLSSKDAEIERLRYIEAEFADFKHSILNNSPPCSTQIPRPIEAEAQKTPRSPILSEKFNHVVLLKTPQKTPKSILKQPGSECKRRRVLLISPEKTTPWDGYFEVESEAEDNQETELRTVDTTSEACPIEAQSCFRSILPRTPNIRGTPPTRVGFKFALLHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVB2</accession>
    <name>A0A0R3WVB2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA-decapping enzyme 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS4686</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005088">
        <property type="protein sequence ID" value="VDM25444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVB2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000470201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000470201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000470201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="98"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM25444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000470201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27206" checksum="25B41624416E7BBC" modified="2016-01-20" version="1">MQNQPTRIPEPTLKLLYSLFISNTPQSLKDEWKSNFARIFSELEYAHWFYLDNCLQDKNEVGLDLFGLCQEIFTRFPNLIPKKTNWKEKFSEWKRYRGATCTGSAIILDDYLSAVLLVQGFNSNRWTFPGGKVGQSETLQDCAVREVMEETGLDIEHRIGKDLYLEVVVGETTHRAYIVEGFPRTSRLQPSTQNEIEAITWFYLASLPAHLQDNEPVAKMKLKPSHFFCVIPFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVN3</accession>
    <name>A0A0R3WVN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BMERB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005401">
        <property type="protein sequence ID" value="VDM25692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000482301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000482301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000482301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265694at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000482301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35501" checksum="DAE202E8D9DBC56D" modified="2016-01-20" version="1">MEPWRYPPQRMIFEPPPMMFTYQQPESLGMMMRPNFLFPPPVSTIPSPMPDTASSIVSLWETEFGPTFTQRREELDAKRRLSVVDFKKKLVRWKELLENSKSASAKEELERLEQECTDPDLLQIMKRKSGRNRRRKRPCQDLPIVLPTSVGETLSRISAADASEPSQQPPPSVPLKEPENTDLSTITKYLADLKSASAFCQEKVRILNKLKQLRDARVAQLRNQGKLIPEQLDEVFEKERHSIYLEIESMQKAITEVTIRLEGAKQALTQEPEQPVVSSDGTVTPLGLPEDVHYLLFGPQNGESLQQRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWC1</accession>
    <name>A0A0R3WWC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Disintegrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5046</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006058">
        <property type="protein sequence ID" value="VDM26145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WWC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000506101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000506101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000506101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disintegrin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000506101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7930" checksum="82E6B0ABA17E12A1" modified="2016-01-20" version="1">MNACIFNFGHCFLPDTSGEALCGNLRLDENEECDPGGAGPHTWDPCCRRNCRLRPGAQCSPMNHACCTSGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWD1</accession>
    <name>A0A0R3WWD1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Skp1_POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5056</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006092">
        <property type="protein sequence ID" value="VDM26159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWD1"/>
    <dbReference type="STRING" id="6205.A0A0R3WWD1"/>
    <dbReference type="WBParaSite" id="TTAC_0000507101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000507101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000507101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="3">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000507101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10668" checksum="A49729291CC747ED" modified="2016-01-20" version="1">MATTQKNESPQETVFGGAEGPDAMYVKLVSSDDHEFYVKREYALTSGIIKAMLSGPGMFVSSMIVVVFLLSAFCSWFEKQNHCLLVQHLGFESKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWQ7</accession>
    <name>A0A0R3WWQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5182</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006498">
        <property type="protein sequence ID" value="VDM26416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWQ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000519701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000519701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000519701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM26416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000519701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25594" checksum="1E13E1BDF3416EE5" modified="2016-01-20" version="1">MLSTETRVQQTPWTQSFPSQVADQPSLTKLFHRPHDLHSALPSPCLLADSSSASSSPSADPRHLEMLMMMTHFQNSSKRRVLFNKSQIAHLEKRFRKQHYLTAQERAELAHSIGLTPTQVKIWFQNHRYKMKRSTSDGTDSASVVGTSSNCVHVPPEVSRHWANNNASSLDVSLRREGSPAALWTVPDGQTLQQQSLAQLQASSMPLPAPQTWTEERRLRRRHVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWT8</accession>
    <name>A0A0R3WWT8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5213</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006630">
        <property type="protein sequence ID" value="VDM26488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWT8"/>
    <dbReference type="STRING" id="6205.A0A0R3WWT8"/>
    <dbReference type="WBParaSite" id="TTAC_0000522801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000522801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000522801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6147534at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="79"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000522801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24125" checksum="E2FE32D5E8C518AB" modified="2016-01-20" version="1">MATDAIDASGTAPSGGEDESVKPSLAVDEGTTEPQHNNDPSTPEPTKELPLRRSNRGKGRSDRSNHGDERVQSCVVGTVEYKPADYVYFEESESDCYAVGIVDEIKLSRREKCTLVVKYFWRTFDVPDVSKQALLDRESADKGDPRILARELFITDLQTSIDCNLLRGKCSVAQFPELINALDSFDPTVEDSFYYVYAFNPESKRLLSIRAEIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWZ2</accession>
    <name>A0A0R3WWZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5265</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006801">
        <property type="protein sequence ID" value="VDM26587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WWZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000528201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000528201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000528201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10558094at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000528201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7431" checksum="D9BCF8CD080A822A" modified="2016-01-20" version="1">MPASRKIRQLRRSKQGRPSGPIKPVHAEGAEEPQELTGAAAYPGYLLSFTQKHQTDDSDVLRTDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXL1</accession>
    <name>A0A0R3WXL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5484</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007701">
        <property type="protein sequence ID" value="VDM27073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WXL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000550101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000550101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000550101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014052at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000550101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25238" checksum="35F5657F5CB90B43" modified="2016-01-20" version="1">MWSLTEWLSTLVDRVPVIPEFLGNSHLSVRGLRDTSWTETLVEVTFLPKAATGLILYSGFSFDTRGDFICVALVRGRIIVSLDLGRGPSFRRSSRNLTLNSWHTLGVKRRGRSFSICLNGGRMFSGPDTFTHGSFVQLTIMDELYVGGMPNPDRISAYLPDYQELVSYKSVKGFVGCIQSVSRRQRECHQDADDIGDEWTHSEGMGYREVDFIWVICQVEQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY63</accession>
    <name>A0A0R3WY63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5688</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008570">
        <property type="protein sequence ID" value="VDM27443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY63"/>
    <dbReference type="WBParaSite" id="TTAC_0000570301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000570301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000570301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000570301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13232" checksum="9E25EB32835C98AF" modified="2016-01-20" version="1">MNVELIAAARRMGCKRTPSLQSSVTKLEHIDDWLGHSPMRKVSSSASLNESTCHPLQCRRNTDVTILRSTVLTRLLTALRLHRQPRCFPPPQVPISRRLLTQACVDINSSLCRQQCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY98</accession>
    <name>A0A0R3WY98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5723</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008745">
        <property type="protein sequence ID" value="VDM27528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY98"/>
    <dbReference type="STRING" id="6205.A0A0R3WY98"/>
    <dbReference type="WBParaSite" id="TTAC_0000573801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000573801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000573801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000573801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13323" checksum="5812614BBFD24010" modified="2016-01-20" version="1">MRTNETERRMSHRNASSNGVASQTDGVRNRADVAAPGATPAADERLAVMAAIAKEVAEQSEAYSTELEMELHRLNAENQALRELLAIETANSIPPSSAGAGAGTANCNTAISSTALRESNGSAASKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYX1</accession>
    <name>A0A0R3WYX1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5942</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01009862">
        <property type="protein sequence ID" value="VDM28019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYX1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000596101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000596101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000596101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00985">
        <property type="entry name" value="Maf_Ham1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM28019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000596101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21503" checksum="3449D47997926420" modified="2016-01-20" version="1">MPLANCGRTGCRFPIKLDKIVCCACSTAFHPQCSDLCPEDFVDKSGSGNWYCPTCAVEITAEGDRVTGVVNAQSTDIGSLPHSFPIAYVTSNPNKLRETIEILGEEYAGMLKQVDVDLPEYQGSSPEEIVRLKCYHAAKIVGGPVLVEDTCLAFDALNGLPGPYIKWFLRAVGPEGKYHKFKCSVFDPYSPFHCALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ68</accession>
    <name>A0A0R3WZ68_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6043</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010442">
        <property type="protein sequence ID" value="VDM28296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ68"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ68"/>
    <dbReference type="WBParaSite" id="TTAC_0000605801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000605801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000605801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="47"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM28296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000605801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26450" checksum="F08BCC574DBB50DE" modified="2016-01-20" version="1">MHLSHTGSYDYFMQKEIFEQPESILNTMRGRVNFNDMSVLLGGIKNNLVDIMRSRRLMLIGCGTSYNAAIAVRELIEELTELPVMVELASDFLDRRTPVFRDDVCVFISQSGETADTLLALRYCLKRGAMTMGITNTAGSTLSRETDCGIHMNAGPEIGVASTKAYTSQIIALVMFALILSADRISLQERRKEIIEALSRLPGELAIVQIAEDMVHARSILVLGRGCHYATCLEGALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ79</accession>
    <name>A0A0R3WZ79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/glucose cotransporter 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6065</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ79"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ79"/>
    <dbReference type="WBParaSite" id="TTAC_0000608001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000608001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000608001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF195">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000608001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="705" mass="77386" checksum="B0C59144A1FC805E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ95</accession>
    <name>A0A0R3WZ95_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS6086</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ95"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ95"/>
    <dbReference type="WBParaSite" id="TTAC_0000610101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000610101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000610101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133142" description="Glucosidase II subunit alpha" evidence="12">
        <location>
            <begin position="16"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="14">
        <location>
            <begin position="92"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="376"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="643"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="740"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000610101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="977" mass="112607" checksum="70A23607152FC77A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZF6</accession>
    <name>A0A0R3WZF6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RPA_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6160</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZF6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZF6"/>
    <dbReference type="WBParaSite" id="TTAC_0000617501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000617501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000617501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000617501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24492" checksum="F6C43BEE939EA626" modified="2016-01-20" version="1">MPCTCAEIVAATQDGDKFVSPTGVLFSQVTLVGLIRSVNESATRIDYEVDDYTGPSVLVKQFIDDDARFESSAESGGCRTLRELTYIRVYGHVRSFQGDINVVAFKAFPVTDMNEITCHILETIYVRMLHAKVASSQTKEDTVPKDSITNSTTNIRGLTALQSQVLSCVRAALDDNGATVSQICEKLRGVPEKQIRDDLDFLSAEGHVYSTVDDNHFRVTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZL0</accession>
    <name>A0A0R3WZL0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SRP54 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6224</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZL0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZL0"/>
    <dbReference type="WBParaSite" id="TTAC_0000623901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000623901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000623901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000623901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="661" mass="72783" checksum="612E780B9C89E064" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZU8</accession>
    <name>A0A0R3WZU8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6328</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZU8"/>
    <dbReference type="STRING" id="6205.A0A0R3WZU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000634301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000634301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000634301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000634301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75716" checksum="9141E654B327CECB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZW5</accession>
    <name>A0A0R3WZW5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6353</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000636801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000636801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000636801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000636801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14651" checksum="654B5A78717C6536" modified="2016-01-20" version="1">MSNVRASDLRTKSEAELLKQVGELKTELANQRLFRITRGAASKLRKIRVLRKSIARIYTVMNQAAKLRQREAYRKKRYVPKDLRPKKTRAIRRRLSKRERSIHSQKTLRKMRSYPTRQFAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X002</accession>
    <name>A0A0R3X002_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6401</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X002"/>
    <dbReference type="STRING" id="6205.A0A0R3X002"/>
    <dbReference type="WBParaSite" id="TTAC_0000641601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34607" checksum="35DCBF2E73F2FD62" modified="2016-01-20" version="1">MLSRGDGCIFERTDGVPPEFGIVGDVDDVNNLVHISTADKSCCVKKSRVTKLESASNDIISQCLDSLNKNFITMQLETSKMLKDEADDLAFYQDPRISGRPRGENEDLCESMNKLSTSDGSQGVVEKRQEGSRRKWQVGDLCLCQWCEDGKWYFAKIIDINDGTGCCDVEFLYYGNEQHFISLDQIHRVEASSWKLVEDEDNTLAAQDLLSTAGMKSDEENLPTVLEPSTQSEKSDVKDTLVQDKRSSRRSELKSSNGPVLSHFWRSFLLETYGNDESAVRNLLYSWYICGYQTGYTMVCILQISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X065</accession>
    <name>A0A0R3X065_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6474</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X065"/>
    <dbReference type="STRING" id="6205.A0A0R3X065"/>
    <dbReference type="WBParaSite" id="TTAC_0000648901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000648901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000648901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YrdC-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000648901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26327" checksum="C91785433FEFBA0A" modified="2016-01-20" version="1">SNRICKFFEAKHLLPEIASILLSGGVVAVPTDTIYGLACCSLSTRGIDRIYHIKGRESTKPMAICLDKAISLSLWSNTEGIEHKLLSSLLPGPVTVLLPRMADDPLNPLLNPCVMDIGIRVPDSSFVCRLSETLATVLRTMGVANGDLHITESCFSASAIPLVLTSANYSGQKSTLSPDEFSELWPQLDLVVDGGRIGGDGSDNELQSSRAGSTVVDLSPAVRSHGQSLHYRILRDGSGFSDVVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0L7</accession>
    <name>A0A0R3X0L7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020314">
        <property type="protein sequence ID" value="VDM30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0L7"/>
    <dbReference type="WBParaSite" id="TTAC_0000668701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000668701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000668701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259906at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133139" evidence="1">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000668701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12074" checksum="53D7FFD28F7D2EAF" modified="2016-01-20" version="1">MSSPKGRLVAVNAYLLLALLLAVVIISADAASVPHWYSRVIEKLNTTLVQNGYYAKCLVDSPVSAIDCKGVAYGAGLKAEAAKDNARYYASATGDYRCGYFVGQCIIRQYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0W8</accession>
    <name>A0A0R3X0W8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020323">
        <property type="protein sequence ID" value="VDM31059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0W8"/>
    <dbReference type="STRING" id="6205.A0A0R3X0W8"/>
    <dbReference type="WBParaSite" id="TTAC_0000680501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000680501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000680501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="548"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000680501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="784" mass="83542" checksum="72818C57F3CC3056" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Y4</accession>
    <name>A0A0R3X0Y4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS6809</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020324">
        <property type="protein sequence ID" value="VDM31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0Y4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0Y4"/>
    <dbReference type="WBParaSite" id="TTAC_0000682401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000682401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000682401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413723at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015792">
        <property type="entry name" value="Kinesin_light_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01160">
        <property type="entry name" value="KINESIN_LIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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</entry>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000751101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1592" mass="175929" checksum="C2CB3F8186D537EF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X324</accession>
    <name>A0A0R3X324_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7707</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020396">
        <property type="protein sequence ID" value="VDM32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X324"/>
    <dbReference type="WBParaSite" id="TTAC_0000772201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000772201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000772201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6223504at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000772201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="26320" checksum="0D76C88116ADF2EC" modified="2016-01-20" version="1">MTSTPRSSMPEQEVRIFKEVHDHYGKQVLQNVRRWEWAVIHEAVTREQLFFLHSCVRNDVFPKSVHYKPPIPTDRAKDLAYKLSVQMRKELITDAHHRLEKYAFEISKWRAICEGQMETSWIERVKTAIQYTADAKRQVKRDYLNQKLQRLRSPRKENQENLIDRLSQMTITRNRRILGDAGQLHGDLGPSFVAFGEDKLDFPSFNAAFGFEFQNSGLYDDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X356</accession>
    <name>A0A0R3X356_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">propionyl-CoA carboxylase</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS7742</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020400">
        <property type="protein sequence ID" value="VDM32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X356"/>
    <dbReference type="STRING" id="6205.A0A0R3X356"/>
    <dbReference type="WBParaSite" id="TTAC_0000775701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000775701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000775701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="36"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="155"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="676"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDM32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000775701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="752" mass="83433" checksum="722FF62BA5A83B1C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X404</accession>
    <name>A0A0R3X404_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS8095</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020447">
        <property type="protein sequence ID" value="VDM32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X404"/>
    <dbReference type="STRING" id="6205.A0A0R3X404"/>
    <dbReference type="WBParaSite" id="TTAC_0000811001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000811001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000811001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000811001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14674" checksum="CCC54492C33C355B" modified="2016-01-20" version="1">MEEDVKSEGVGILFCSECNNMLYPKEDKRHKRLMYACRNCEFMQPADNPRIYVNRMEQDIDELALIVPDVVHDPTLPRTEEHQCPRCKKQEAVFFQSQTVRAEENMRLYYVCTNLDCLYKWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4V0</accession>
    <name>A0A0R3X4V0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur clusters transporter ABCB7, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-binding cassette sub-family B member 7, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8442</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167627"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67029"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020506">
        <property type="protein sequence ID" value="VDM32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4V0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4V0"/>
    <dbReference type="WBParaSite" id="TTAC_0000845701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000845701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000845701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="100"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="455"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000845701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="707" mass="77519" checksum="2CCCC4C86C2A2707" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5F8</accession>
    <name>A0A0R3X5F8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8684</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020562">
        <property type="protein sequence ID" value="VDM33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5F8"/>
    <dbReference type="STRING" id="6205.A0A0R3X5F8"/>
    <dbReference type="WBParaSite" id="TTAC_0000869901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000869901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000869901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000869901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21864" checksum="88236034B720FE8F" modified="2016-01-20" version="1">MALAKLLKPDKSLPTPLEEEIAATLVDLQSHEDMSESVKMLYFCGAKEFSIGHEKAIVIYVPVPQLRTYHHLHNRLVGELEKKLRGPQVFIVAFRRILPKPRRKCKSNPKQKRPRSRTLTAVHQAILKDIVYPAEIVGQRIQIKIDGSSLIKCHLDIAQRNYVEHKLKTITGLYKKLSGKDVAIEFPDWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5Y3</accession>
    <name>A0A0R3X5Y3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Solute carrier family 28 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8884</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020616">
        <property type="protein sequence ID" value="VDM33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5Y3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5Y3"/>
    <dbReference type="WBParaSite" id="TTAC_0000889901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000889901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000889901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="318"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="420"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000889901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="693" mass="76143" checksum="93C1569718246CB6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X627</accession>
    <name>A0A0R3X627_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8930</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020629">
        <property type="protein sequence ID" value="VDM33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X627"/>
    <dbReference type="STRING" id="6205.A0A0R3X627"/>
    <dbReference type="WBParaSite" id="TTAC_0000894501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000894501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000894501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="5">
        <location>
            <begin position="652"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000894501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="747" mass="82143" checksum="EAA0F4D27765AE15" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Q5</accession>
    <name>A0A0R3X6Q5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9185</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020707">
        <property type="protein sequence ID" value="VDM33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Q5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Q5"/>
    <dbReference type="WBParaSite" id="TTAC_0000920001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000920001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000920001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266673at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="43"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000920001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="803" mass="88119" checksum="85725B272DB1350F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8P2</accession>
    <name>A0A0R3X8P2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9902</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021147">
        <property type="protein sequence ID" value="VDM34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8P2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8P2"/>
    <dbReference type="WBParaSite" id="TTAC_0000991701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000991701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000991701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278340at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000991701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33289" checksum="C941F7777A413EC9" modified="2016-01-20" version="1">MTLNITFPRESVTRQVVILQVVRRNGLIRCNKLFLYPGISGHQMHLIKYDQTQCMRLLEGLRPKINLAKIWHAYFAFHRYFVATLSTEAEVKARNQQQQGTENILDSLSGLSLHKSTEHQMPTASSSADSVATQCPPISGEIDNKASFRHGRVSIPFSNLMRNFTSTVAWRALCAAVDSPDIIQVCSHGDADIISPAEMQSLEKTLASASKFRTECMDSATPSPVPYHRRLLREILKPVGIDWKALTTPALLPLTTDYFPEASSLLGEEYMIHEYRIVLITISDKEWNLHFGQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8W8</accession>
    <name>A0A0R3X8W8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9978</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021209">
        <property type="protein sequence ID" value="VDM34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8W8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8W8"/>
    <dbReference type="WBParaSite" id="TTAC_0000999301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000999301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000999301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000999301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31398" checksum="941FFD086A1DD7F2" modified="2016-01-20" version="1">MSKNPETSHLSSRPDLLNIDREYADNLKILLDNSPGKGIVQSRVALISNNDKRDSIGERNDIVSPSMDSSRKGLSLTVFQNTASDGVSVPQRNHGLKSIPEEILSPDRKIDASNDAHFGQDSVRTFHTTFFLGTSDKPPNVVDLSKPVKISAPVMRSKSFGRKNMSARIQSLLENFESSECSFDSSSLPATPRSIEKRPAKQFSPEVSMSENKSSAEACFACNKVIYPLDRYSTGSHVYHKSCLRCSICDRSLSGITCESSKDKLFCRPHFLEKAHGISTDNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9L8</accession>
    <name>A0A0R3X9L8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10228</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021447">
        <property type="protein sequence ID" value="VDM35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9L8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9L8"/>
    <dbReference type="WBParaSite" id="TTAC_0001024301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001024301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001024301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001024301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="478" mass="51833" checksum="DAF97C243EB953FE" modified="2016-01-20" version="1">MVERVFDRLPFDSLRCSDDFIVHKRLLSSGILEIPSQMIWLFLNALSTFRQGKQLVKYIGDFYDKSYVPGGGRSSVVSLDWSTLHPELLLAAYQSQTREGSGTGDGNGFSEVGVESSCCCVWNLKYRQTAPEYVFTYRVDITAATLAEFNPALVIGGTRGGQIVLWDSRVNRRTPVQMTHLAGDGAAHVEAICGLVDTGNRFSNNIISVSSEGRLCTWAVDMFGAPIQTLDLTPSSGTSASSGGMKRSSNPITPTCLALLPDPDASRFLVGSQDGSVYAGSRHGKNAGLTVQFEGHRAPVTGVSVLAGAEVAALSDGVSAVTVCGVEGPLFVTTGMDCSVRLWSVRESPAYPLLSYEDRNDYFVGCDASPIHPGLFATTDLSGCLDLWSLNSDHEVPTASTLVEGDALLNRCRFHKKGFHLAVGGDDGRVRLFELHENLAMPKSDEHVQLNHLIRKLSNSAAEEYDVQNHAYRYGHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA51</accession>
    <name>A0A0R3XA51_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021667">
        <property type="protein sequence ID" value="VDM35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA51"/>
    <dbReference type="WBParaSite" id="TTAC_0001042801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279657at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32461" checksum="E1812C6CD56EB5AB" modified="2016-01-20" version="1">MNRRPVTFENSDDIRLDPYFKNLPSATSEKQRCSNNHREDPGSSSNSRNRVNGLSSRERRNKFRSKSIESSHHTCDLNSKSNTSPSSQAIQEDMDQPVNGGGQYRHFPPADEVGGDSSDMLNSSSIGDDHLSRRRLVSSNNINTNPTSRDSDIDNEAPEIDDDDDDNEVGTNANDLSTVYHMRRQQRRQQQRLRRRDTSSASVCGDTASRRRQPISLSRSSTRIGQSSIPPPPSEPPPSLPPCGIDLSSQYSMYPVLGGGGFNLVGQQPSATPPTMLQIAGLPVNYLPPGKHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAM6</accession>
    <name>A0A0R3XAM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribos_L4_asso_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10586</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021904">
        <property type="protein sequence ID" value="VDM35566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAM6"/>
    <dbReference type="STRING" id="6205.A0A0R3XAM6"/>
    <dbReference type="WBParaSite" id="TTAC_0001060301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001060301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001060301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="253"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001060301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40028" checksum="1F98BB97A571A4A9" modified="2016-01-20" version="1">MPAVFGAPMRSDILNFVHDSLRKNSRQPYAVSSKAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGHMYAPTKVWRRWHRRVNIQQRRFAMCSAIAATGVPALVMARGHRVNKIPELPLVVSADIEKIKKTKEAVKVLKKLRAWSDIQKVYNSKRNRAGRGKMRNRRHIMKRGPIVVYKKDDGITRAFRNIPGVTLLNVKYLNILKLAPGGHMGRFTIWTEGAFRTLDKLYGTWKTGSSMKNGFHLPSSKVTNTDLTRLLTCRAIRNVLRPRRMDHQRRRSHVKKNPLKNMQVLIKLNPNAISERNARIGALRAALKRKIRKSEKPKSACRKVITEEKKDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAW0</accession>
    <name>A0A0R3XAW0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10670</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022025">
        <property type="protein sequence ID" value="VDM35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAW0"/>
    <dbReference type="STRING" id="6205.A0A0R3XAW0"/>
    <dbReference type="WBParaSite" id="TTAC_0001068701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001068701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001068701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75502at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001068701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25498" checksum="EF656718072BB76F" modified="2016-01-20" version="1">MYGSVEVILHKQKYASLGITVSGGVDRGYPPRITAIKPGSIADKSDCILVNDVIKAINSAVTANYTHEQIVKLTKNADTTIRLELEYVLTDFVKAATTKYAFIHLEPANESFGITVRGGLSHVGNGAFPLVICRIRPNSCADLNGCLKQGDRILAIDGVQTCGLTCEESMKLLACCRSGKSLFIEYDVADIGGKGRKERRQKSTFAWFALFKLRRHRGTHTCQQRSFEHTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB29</accession>
    <name>A0A0R3XB29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BLOC-1-related complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10739</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022159">
        <property type="protein sequence ID" value="VDM35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB29"/>
    <dbReference type="STRING" id="6205.A0A0R3XB29"/>
    <dbReference type="WBParaSite" id="TTAC_0001075601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001075601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001075601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044187at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146:SF0">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146">
        <property type="entry name" value="MEF2B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001075601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15755" checksum="4817EE57EA9CF37B" modified="2016-01-20" version="1">MSRLVYNCSVGTVVNLVNEPSVALFRIQEHIRKSAPEIVEERRKAFVCAEKLQGISFDLDNTLDVISAFPKLESNLTHLLETLDACIVHRQYLQASQQNRLVSCLVFSCVQFFVLVLMYSKRDDFELGVDVVALLATDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB78</accession>
    <name>A0A0R3XB78_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10788</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022244">
        <property type="protein sequence ID" value="VDM35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XB78"/>
    <dbReference type="WBParaSite" id="TTAC_0001080501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001080501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001080501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="170"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001080501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="576" mass="64535" checksum="7E0BEF38E96AC018" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB98</accession>
    <name>A0A0R3XB98_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vps5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022269">
        <property type="protein sequence ID" value="VDM35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB98"/>
    <dbReference type="STRING" id="6205.A0A0R3XB98"/>
    <dbReference type="WBParaSite" id="TTAC_0001082501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001082501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001082501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001082501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27426" checksum="150870D150656736" modified="2016-01-20" version="1">MKLLKNVGEAVGKLTFRMDEVDEYFDLKDDELENWDIQGSRLYAAFSNLVLDQNDLVASTLTSSKALSALANVEEHTGLARALGQLADTEEQLAHFLSVEVEAQSTFLVEYAKGVLSSVQACRDTLAERVRACKMRRDCESALRGKREQKVRIEMSPKADRAKIPILEREIGELAHRVEESEEEFEKISTTIKREFERVDEARFKEFREAVLSYLTMMLQMQEKTLKVWESFVGHAKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBA7</accession>
    <name>A0A0R3XBA7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10817</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022296">
        <property type="protein sequence ID" value="VDM35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBA7"/>
    <dbReference type="STRING" id="6205.A0A0R3XBA7"/>
    <dbReference type="WBParaSite" id="TTAC_0001083401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001083401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001083401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001083401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14869" checksum="78019C47CAFEA204" modified="2016-01-20" version="1">MAELVCAILLVAIAIDIIYTFYTRIRKQPRTQSDSTGSSDKPHNLGVVIACYMAQITFPTTILQAVHGIVGCVYVPASSGLAHAIFALLFLEFRTKAPGAHTIAQFVGHRFGVAAHVLTIFISLFTALYNLTINAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBE0</accession>
    <name>A0A0R3XBE0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPR_long domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022365">
        <property type="protein sequence ID" value="VDM35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBE0"/>
    <dbReference type="STRING" id="6205.A0A0R3XBE0"/>
    <dbReference type="WBParaSite" id="TTAC_0001086701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001086701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001086701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133315" evidence="1">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001086701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36488" checksum="66CE55BE745DAD97" modified="2016-01-20" version="1">MFFLRHRSVLAFVLRVAHSKTLHFSGRQPCPLLPTPVLANVSYSAYPTPGNREERSLLTENDAKNASFQMQLAERNRLNIRLMDTEQQRVYFNELWDKIAAVFIRRSCERGNMEETSFYLKAMHQEGAVPNDYIFSKILHGYVKCGLPDEVATTQDVMSKLNYWPSMMATEDLLSAYADLGDGNGVIELLQETLNRSESLLNRPVFSPRFLADLYARLAVAPQFDTNEQAASTILGLLRKRPPYFDDFRLGIALTRLLKAGHNDAAFQFLRGTHPHTFTPYFLSKISELLVEQDPKTLADFWLSSGAFSRLPEVIRTMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBN7</accession>
    <name>A0A0R3XBN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022597">
        <property type="protein sequence ID" value="VDM35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XBN7"/>
    <dbReference type="WBParaSite" id="TTAC_0001096401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001096401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001096401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001096401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="544" mass="58438" checksum="D5B96F6395D2E76C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBS5</accession>
    <name>A0A0R3XBS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10985</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022669">
        <property type="protein sequence ID" value="VDM35965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBS5"/>
    <dbReference type="WBParaSite" id="TTAC_0001100201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001100201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001100201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001100201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9339" checksum="C35F14280646A6A2" modified="2016-01-20" version="1">MVSWPVICSLLCTQFAEEKECILKWQKCALNAAAAAAAAAAAAVVAVTVAGTTASTIHVALRLIGWFDYWREASLSPSTPSPSCRPSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBV0</accession>
    <name>A0A0R3XBV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11011</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022736">
        <property type="protein sequence ID" value="VDM35991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBV0"/>
    <dbReference type="WBParaSite" id="TTAC_0001102701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001102701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001102701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269733at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008860">
        <property type="entry name" value="Taeniidae_ag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05596">
        <property type="entry name" value="Taeniidae_ag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001102701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9050" checksum="6392004B0B2F4556" modified="2016-01-20" version="1">MPSIPPPPPPPSSQKNPVRVLRDKYKAKVAKWEKFFDEDPLGQKIAEHYANLRALVQEARQRIRKALANYVKQLENEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC05</accession>
    <name>A0A0R3XC05_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS11065</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01022845">
        <property type="protein sequence ID" value="VDM36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC05"/>
    <dbReference type="STRING" id="6205.A0A0R3XC05"/>
    <dbReference type="WBParaSite" id="TTAC_0001108201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001108201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001108201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="66"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001108201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="48242" checksum="A1ADC48FFB714C26" modified="2016-01-20" version="1">MMMCLAAECQHQPGRRAALTELQLAHRDVYTVLFGSNPASRSRIDPSLLATVRLCRLPSVLEKSEAIERTNEHPQITKILIIDWDVHHGNGTQTVFYADPTVLYISLHRYDDGAFFPGTGAIEEIGAGMGAGFTINIAWPSGITMADAEYLAAFRYIILPVAQEFKPDMILVSSGFDAAPGHPANLGGYNVSPAAFGWMTRLLTNQDIAGGRLALCLEGGYELTSLCDCTEACIRALLRSTYERTTGLQDAPLLYRLSDRERTREPHPAALATLKQLSHFLTPYWKSLSVSEIAGTSADAWLPSGEEEEPSLLPVIKKLTSVNASDQCKRSLGKLDSKNKPNSWPETELVIGAGASGQQINPRRFVKQACLEEDDVSTAPEDVPLDMTAKSMRLTPHGMGLQHALKMEADVNETSTESTDLITAAALVGLADLHVTPQIAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC53</accession>
    <name>A0A0R3XC53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11113</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022990">
        <property type="protein sequence ID" value="VDM36093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC53"/>
    <dbReference type="STRING" id="6205.A0A0R3XC53"/>
    <dbReference type="WBParaSite" id="TTAC_0001113001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001113001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001113001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001113001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7882" checksum="4DDAAF3FFCB1BAA9" modified="2016-01-20" version="1">MPEYKLVVVGEDSYRKQVNIDGETCMLDILDTAGQEEYRYAIVPSVFQILFFSAMRDQYMRTGEGFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC66</accession>
    <name>A0A0R3XC66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11126</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023021">
        <property type="protein sequence ID" value="VDM36106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC66"/>
    <dbReference type="WBParaSite" id="TTAC_0001114301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001114301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001114301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001114301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7870" checksum="3D24210FB64997B5" modified="2016-01-20" version="1">MVCLAKLPFLPVAASRSVQTSFPNGLLSSIALRFPSFPQPSILFGRCPYDYLEEDDRVENYEEGRRESGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE29</accession>
    <name>A0A158RE29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">I/LWEQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6524</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE29"/>
    <dbReference type="STRING" id="6205.A0A158RE29"/>
    <dbReference type="WBParaSite" id="TTAC_0000653901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000653901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000653901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8178130at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="5">
        <location>
            <begin position="499"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="276"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000653901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="751" mass="82964" checksum="B9B33058CE14962B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REG2</accession>
    <name>A0A158REG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYWX01020356">
        <property type="protein sequence ID" value="VDM31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REG2"/>
    <dbReference type="STRING" id="6205.A0A158REG2"/>
    <dbReference type="WBParaSite" id="TTAC_0000725901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000725901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000725901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF4">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000725901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="689" mass="79086" checksum="15A89E0D7C9E2EC7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF34</accession>
    <name>A0A158RF34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8710</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020567">
        <property type="protein sequence ID" value="VDM33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF34"/>
    <dbReference type="STRING" id="6205.A0A158RF34"/>
    <dbReference type="WBParaSite" id="TTAC_0000872501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000872501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000872501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000872501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29576" checksum="A603F9FF1B641672" modified="2016-06-08" version="1">MAFINPKRMGTYTLTPAGTSIATDDSNVGQQMLRKMGWSPQSGLGKNGNGAVEPVKASCNYGRKGLGKVPTQFSTGMVQQSVFNTILQSLTKHKSSVGPGKKTKLEDKSKQSQSRVHYGKFVRAKDVSQYSQKSLKIILGGPVGRTQNSPEHGIAPSPPENNWPRDASIKQEFGVKTYSSSTDMASYFSLKRRAVKSDTEGLEARKRARLTPPNDEDKEGKPTFEDQIEATEGHTRRKMTRLCLTLFSLEQSTAFSSSNVHSLSGYPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF73</accession>
    <name>A0A158RF73_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9092</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020677">
        <property type="protein sequence ID" value="VDM33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF73"/>
    <dbReference type="STRING" id="6205.A0A158RF73"/>
    <dbReference type="WBParaSite" id="TTAC_0000910701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000910701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000910701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6259814at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14699">
        <property type="entry name" value="bZIP_Fos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="358"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000910701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="674" mass="70123" checksum="E8E679F179A516F4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EP97</accession>
    <name>A0A3P7EP97_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS4451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004470">
        <property type="protein sequence ID" value="VDM24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EP97"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="119" mass="13710" checksum="FA3EB46ABCA1F33F" modified="2019-02-13" version="1">MRTCWQRVGGFQVVGDLLKKAYSNALQVFFDATTRQLRRLADPLYFGGMPLPAGHLMKRSTNWFVSGGGTSDPSGWQRRRRETQYGEKWIKRQKDKLVYLDYSPDYCKADQKIGTQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FB96</accession>
    <name>A0A3P7FB96_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020324">
        <property type="protein sequence ID" value="VDM31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FB96"/>
    <dbReference type="OrthoDB" id="442428at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="124" mass="14226" checksum="0F013C0429E4A6F4" modified="2019-02-13" version="1">MDELVSIFKQFDNDGNAVMTPRNVALESTVLTLGFVSVDDFKEKCKKLYEDKGFTSTDSTISKLAMLLDFNSDGIIDFNEFIEGSRLAREKCKRSPLQRHWRTPRDRGHIYLKSVCHFVDAPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGZ9</accession>
    <name>A0A3P7FGZ9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10251</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021477">
        <property type="protein sequence ID" value="VDM35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGZ9"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="615" mass="68287" checksum="1FE22D7C7D3E5387" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FHM2</accession>
    <name>A0A3P7FHM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010335">
        <property type="protein sequence ID" value="VDM28259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FHM2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="34" mass="3826" checksum="C8FD7D4F0735F6F6" modified="2019-02-13" version="1">MPERLIKTLTRISTRLIAPAGHAHVEDGVSDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FNA1</accession>
    <name>A0A3P7FNA1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FNA1"/>
    <dbReference type="OrthoDB" id="6273184at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31902" checksum="85218FF4AE12BFAA" modified="2019-02-13" version="1">MNSRSKSTACLVEKTPTDSFDFENGFSSHPGELNSVSHTRTKFCRHKHGKVRAPLAKRGFSLSRFFQRSSKTFDSPLEDEREAFDESHSPSQPLTLGHIYSSSSTNLKESDSWTSLLDERSRQAPTQQSCKIPSANEIRTGKPNTLRTNSEQVFNRENPTGALSTVDSVCLQKSCANASADEVKNITTSEPAMLRRRLALRRRLLSRSRQPLDESAGHQLRNHEINIKSQGLEFGGFQASLLGGRRHSFYVKTLAGETYIFAAASQDERDCWLTWYASYPEECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FP77</accession>
    <name>A0A3P7FP77_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KCMF1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FP77"/>
    <dbReference type="OrthoDB" id="7873042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02338">
        <property type="entry name" value="ZZ_PCMF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="387" mass="42011" checksum="341304D0B3861C1E" modified="2019-02-13" version="1">MSNFSCVVYVVGIKCDACEANAFRLRRYKCLRCVDFDLCGPCYDRRAEALSHRKNHPMQCLILESDRKIFFPNSKSNEMARSYICPICGAPGFKAVDLGAHVHAKHSNSRMGVLCPICIYPPLGNSAGGRSSNPNRIHNSFSTHLSDVHRLKALTSGTPTTTTPDILSPAVIETFLTRDPNYFYEPAETEQRVCNHGSFGRSLLSAEEQELFDLIATSSMVPDGQGLRFRTPHNSSPSVSGQVSHSEQVASSKVIEKQADSSRPEAGDEASESGPQLALLNRNINSNNNGGEENNGNAESQEHAVSSATVVGSITVEEVQSDSVAAPVEPVSSLVSYGDTAAILDPRVFEAAKKKCDPVWLSFVHELIWDSLHIAGLSLTPSEGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FWK4</accession>
    <name>A0A3P7FWK4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS11563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01025042">
        <property type="protein sequence ID" value="VDM37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="329" mass="37833" checksum="4FD9DE2CE7F25938" modified="2019-02-13" version="1">MSHTIPRIILRSRLSVSHLQPTHSLPPSAHQHLRSSASRTAHTRLLTITLACTCGDSLQVRCVQFRGEEASTTTLPPTTHQHLHPPIFSVGLPRTSLSNVFQRDGFNVTLRNRAGQKLLQHGRFPFRSNKMFVKEMRDHDDLLVGDYEDTYYNLSLKLFYTFQWAARFCRPYNPTFVFLDDDYAVNTMRLLTFLSYLTPDQFDNLNHGLDVVVNAVARNTSSVVRWAFSKREIPWPRHTPEYFGIYSLWSYRHVHDMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPFILHRRLSKFNAPTSSLLLCTTSKHAIVTCEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FXU5</accession>
    <name>A0A3P7FXU5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020713">
        <property type="protein sequence ID" value="VDM33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FXU5"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF58">
        <property type="entry name" value="CERAMIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="200" mass="23483" checksum="19539578B18F16B7" modified="2019-02-13" version="1">MYMFQIGFYAHSFYAALRLDVRRKDTSVLLIHHVLTIALLSFSFFAKFHRVGLLVLFLHDISDVILELGKFFIAVRSKYPEYANILEHIANCLFAAFVLSWFYLRIYLFPTKVIYGTTWGVYLTHLDREAYFFLFFNTMLTTLYLLHIYWSYFIVVMLGKIAMGRMPKIEDERDFDSDTSSNGVCKPAMANGIRKKEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FZK0</accession>
    <name>A0A3P7FZK0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020603">
        <property type="protein sequence ID" value="VDM33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FZK0"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="256" mass="27823" checksum="26827229B9F8EAD2" modified="2019-02-13" version="1">MTALVELRADIKGHLSYISSSSLNFIHSDELILTVGYSKSVFNFLKFRVIVCEAFPSNDGHKMAESLAMEEISVVLVPDSHVFGLMARVNKVILSCNTVYPDGALKAQTGTYAVMLAAKHFSIPATAQAANPFQTYVCLPSYKISPVNFKLLPNCSNTLNSHAQCAPESMTGLIETADLSVNALDAPSRLLPASECLAGGGPSPLIWLPNWDYIPPGLTSLFLTTEGGQAPSYLYAMVRELFNSDDVNQSLKWVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GCK5</accession>
    <name>A0A3P7GCK5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001130">
        <property type="protein sequence ID" value="VDM20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GCK5"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="90" mass="10444" checksum="CD8900E9F40DF63E" modified="2019-02-13" version="1">MVLEIPLFLHQIPLAGLQVQRQRQLRRHLVALPPLQLPLLSLQLLGLLLLPQAYASPLPKQRRLCKKWLHQWPTLAPEQGLKNQRLREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GP83</accession>
    <name>A0A3P7GP83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003422">
        <property type="protein sequence ID" value="VDM23922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GP83"/>
    <dbReference type="OrthoDB" id="6250648at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="818" mass="86158" checksum="6F7590F8F00090A5" modified="2019-02-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GT24</accession>
    <name>A0A3P7GT24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004729">
        <property type="protein sequence ID" value="VDM25162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GT24"/>
    <dbReference type="OrthoDB" id="10047184at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="288" mass="29564" checksum="6BEF917051BBF3E0" modified="2019-02-13" version="1">MLYESLRLIVDSLRKKQLSKADEAGDFDPAGSEEGACTTEEKESSLAASSSLSLIGDSTLGGGGGGVHHHVPTSSYVNASTVVAAALAAAAAQRSAAKATSATAPLPATSTASGPPVSSHHDHHCQKTEGRWRPGSWLRRSFVLLWRRRASPASATAAVTASCAKPLLQDDIMSIIAYHQAKASKQCRPPGANILLLGECVLEGVLTEWLGPGGLGGSGGAGVGGGGSVCTPPPPSASSTSSAFSVPGLLVLQDNPQWARSRLLLMRTSAGYVLEVYTPPEFLTLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GX23</accession>
    <name>A0A3P7GX23_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008078">
        <property type="protein sequence ID" value="VDM27268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GX23"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15977" checksum="61BF1E7E522B3418" modified="2019-02-13" version="1">MTWNVAEENKASFADPIIYVLQVRTYFGPEFDPMAASAWRTLTMTTVPGARLSEPDVGWWYQYRIAAVSRFGSRGFGDSTTPPVRLTSQLPQAASAPRQLVDGVWRFQADGGVHVRIEWKAPATAVIPVTEYRVGTELIQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H962</accession>
    <name>A0A3P7H962_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS7232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01020355">
        <property type="protein sequence ID" value="VDM31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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            <end position="269"/>
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        <source>
            <dbReference type="EMBL" id="VDM31578.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1624" mass="179664" checksum="5874A072C33A0A2C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HCN6</accession>
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        <recommendedName>
            <fullName evidence="2">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">TTAC_LOCUS7736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="977"/>
        </location>
    </feature>
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        <location>
            <begin position="829"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1013" mass="115590" checksum="84C0883A56F3F4FE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHY7</accession>
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        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS181</name>
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    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDM16037.1"/>
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        <property type="protein sequence ID" value="TTAC_0000018001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000018001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244905at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF160">
        <property type="entry name" value="PEROXIDASIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="167"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="320"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000018001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="720" mass="78449" checksum="4B83577AF8F51421" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIL9</accession>
    <name>A0A0R3WIL9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recep_L_domain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS455</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000040">
        <property type="protein sequence ID" value="VDM16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIL9"/>
    <dbReference type="STRING" id="6205.A0A0R3WIL9"/>
    <dbReference type="WBParaSite" id="TTAC_0000045401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000045401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000045401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235929at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000045401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32323" checksum="A2FA5EE0C4EE1FE2" modified="2016-01-20" version="1">MVVDGRRSVDRFIRLKGTLSIRNPENNHDHNFPISHETITMRGPPLGQTAIYDVPSIGAVQNMLRLLTPYLHYINSLTSFPSRNSRFYNVFSLTGGFSNLVLLRFNVSYQGLGNLLIETTIQRSISDPDYFEGNMNVEVKTGKSFKVPRETYVERQFGDGTIDYSKIARGVLRFRRKHMKLAAINRQSSKVLRVSIVGTGYVTVDEAACLLQNGSLVEEAKDGFSVLLNPKGYCNTACPHSSTFCTIYCLDYPVLESRQACEYKTISHPCVPRFFNLSNLGFVYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ62</accession>
    <name>A0A0R3WJ62_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS692</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000079">
        <property type="protein sequence ID" value="VDM16851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ62"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ62"/>
    <dbReference type="WBParaSite" id="TTAC_0000069101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000069101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000069101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054061at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000069101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11313" checksum="E3B2FAA04F94F64D" modified="2016-01-20" version="1">MSDDFDPCECIYNYELSMQRLLSMLRQSQAYCNDVYCQSNPPNSDLNLNDNSVSASFLVFFAWILAVAGILAFRGLRRGNSNGFNKPGPARNNDPEPPTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJA4</accession>
    <name>A0A0R3WJA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS743</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000087">
        <property type="protein sequence ID" value="VDM16924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WJA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000074201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000074201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000074201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM16924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000074201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38300" checksum="7692CEEFEA06A80B" modified="2016-01-20" version="1">MTTNEASTQPRNSLANLELLAEEQTIAIKELESKIKKIEEENEKLIEKQKSQQEDLSRREAAAIRRFIVTDARLAHILSVMPSKLRRKSSDVEFDSEGVEDSIDDYGEEVRSVKVKEQIHQLNVLDPAIDFVYQKASEAAQSGKMRLQQSFDDLIAWKFTPDSASGKRLMACMRELLERNKHLGAINQMDRLSALESETQMQVSCIREYMKTAQELNAVLQESSTDLDGVQSSLFTLKKQLNKAEALVTALKVRSRSVYTFGVHIGYHYASDWIFTLKEEYEKVYPGQSDSLITAALTRLSQQAVAEEGGGCESQEDADARSVVESEAPAATSETSLHELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJX2</accession>
    <name>A0A0R3WJX2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TMEM131_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS994</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000151">
        <property type="protein sequence ID" value="VDM17282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJX2"/>
    <dbReference type="STRING" id="6205.A0A0R3WJX2"/>
    <dbReference type="WBParaSite" id="TTAC_0000099301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000099301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000099301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252375at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000099301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="784" mass="86717" checksum="6F04AB76C1A1D149" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK01</accession>
    <name>A0A0R3WK01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Trimeric intracellular cation channel type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1028</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000160">
        <property type="protein sequence ID" value="VDM17331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK01"/>
    <dbReference type="STRING" id="6205.A0A0R3WK01"/>
    <dbReference type="WBParaSite" id="TTAC_0000102701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000102701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000102701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000102701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35685" checksum="7237908307CE760A" modified="2016-01-20" version="1">MDPQIIDDIATSVSKWRMYPHFDVAHYILMSTAVREDIPQSGSGAFSRKHPFACWFATMLMCFGGAILGNFILGEPVFACFDDHRAVLTATAVWYLINYSPFDVIYKIYSFFSIRLLICAMKEVQRAKKISLGVSHAYHDYPHSAVTCILVGLLKGTGYLEMKIFARLVRGVWLPASTEFLHPSFTTKISLLSAIVFYCDLLDLIPLSRHQLFLAVVGVLVYMRVAMLCLGLKDPFAPIQNLVCTIFFGGVVDALKAAVTRRKSGDASEAVANTPNVITPNTGVGAAQDGYSGSSGSGGVKESSGATMLRRNNPPNAPHSADKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK10</accession>
    <name>A0A0R3WK10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ldh_1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000162">
        <property type="protein sequence ID" value="VDM17351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK10"/>
    <dbReference type="STRING" id="6205.A0A0R3WK10"/>
    <dbReference type="WBParaSite" id="TTAC_0000103601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000103601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000103601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273706at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000103601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9005" checksum="AD72FBBFD642D47C" modified="2016-01-20" version="1">MPYLRSNLKRREHNRTTFNTCQGMNLPGIDKDIFMSLPCIVNANGVRGVMFEDLEDEEKEKLYASAKGLEELILSINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK31</accession>
    <name>A0A0R3WK31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000169">
        <property type="protein sequence ID" value="VDM17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK31"/>
    <dbReference type="WBParaSite" id="TTAC_0000105901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000105901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000105901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6225884at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000105901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8234" checksum="B12BB7729F430FDE" modified="2016-01-20" version="1">MLSKFFTKRFGQVLRFTRRCYKMPNPYRESYRPEYDPIVIAGFVLFTAPVVWMIYDIAFETDKDIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK34</accession>
    <name>A0A0R3WK34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BH4_AAA_HYDROXYL_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1063</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000169">
        <property type="protein sequence ID" value="VDM17396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK34"/>
    <dbReference type="STRING" id="6205.A0A0R3WK34"/>
    <dbReference type="WBParaSite" id="TTAC_0000106201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000106201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000106201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000106201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="348" mass="40346" checksum="403F0CE6D756FD00" modified="2016-01-20" version="1">MDITIPWFPRHISELDVISNNVYMYGKDLDAEHPSFKDVAYRKRRLEFAKIAYNYRYGDAITRIEYTTEERKTWSTVYRELMTLYQTHACKEYLENIPLLQEHAGYREEDLPQLEDVSKFLKKQSGFTLRPVAGYISARDFLQGLAYRVFYCTQYIRHEAEPFYTPEPDCIHELMGHVPMLANPEFAQYSQELGLASLGVSNEDVQKLAKLYFFSVEFGICNQDGELRAFGAGLLSSVSELKHALSDGAVRMAFIPDEVVKAECMVTTYQRAYFITTTFREAQDKLRHFVQSLRRPFALRYNAFTESVEVIDEPSKLKTLLTDIKTQILTLGDALNQALKLLRTEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL15</accession>
    <name>A0A0R3WL15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1435</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000313">
        <property type="protein sequence ID" value="VDM17990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL15"/>
    <dbReference type="STRING" id="6205.A0A0R3WL15"/>
    <dbReference type="WBParaSite" id="TTAC_0000144801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000144801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000144801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000088">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000144801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="860" mass="99034" checksum="5AD4134D967878C9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL70</accession>
    <name>A0A0R3WL70_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1493</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000343">
        <property type="protein sequence ID" value="VDM18100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL70"/>
    <dbReference type="STRING" id="6205.A0A0R3WL70"/>
    <dbReference type="WBParaSite" id="TTAC_0000150601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000150601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000150601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000259">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000150601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15400" checksum="5351BD79135ED795" modified="2016-01-20" version="1">MSSIGTEITNLEDLRDPSGIFALIEVVGKGTYGNVYKGRHKRTGQLAAIKVMPITEEDEEEILLEINTLRRLSNHRNIATYYGAFIKKATPNDHLWVSLHSAGNFHQDEVSKSSAPLSLFFFKSARDGILWGGFGDGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLC8</accession>
    <name>A0A0R3WLC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1767 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1553</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000372">
        <property type="protein sequence ID" value="VDM18200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLC8"/>
    <dbReference type="WBParaSite" id="TTAC_0000156601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000156601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000156601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253090at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000156601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62642" checksum="052B5A4C3B644FF6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM79</accession>
    <name>A0A0R3WM79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1854</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000556">
        <property type="protein sequence ID" value="VDM18594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM79"/>
    <dbReference type="STRING" id="6205.A0A0R3WM79"/>
    <dbReference type="WBParaSite" id="TTAC_0000186701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000186701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000186701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000186701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44453" checksum="DC874EFE361E10EC" modified="2016-01-20" version="1">MEAKNMTTAATNSVTTDFVLDSHKYAIIAKEFSYYVNTLNYNVNKRIIMALYCLIFLLGSCLNLLLVYTIMRVRNPKSTSNRRMLLMHVCCDLALVWFGVPYTAYTVVYKSWQLGSVMCHVASFLIYFIVGLTNFLLVSICLNRSIAIARAGRWAGESDYDVNCRVTVLFTAAIVLAVVIALPSAIVSRVTNNIFKDPLFTALAPPICIETWSSRAKMAYDLTLIITIYFIPLIVICLSHHIVTQQLRRSHHMLSLMGHTISAKWRRRRQRLIRLCVLMTTLFVLSWFPNHLCNILTKIFDVRGDTAETLQDYALCLGISNTVSEPLLLITTCSAYQRFIRRLLARWRLVKSAADAVEPIVSSSIGAPVLPTPVPQLTNGNKSDSQVAPSVQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMT0</accession>
    <name>A0A0R3WMT0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Thioredoxin-dependent peroxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2055</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000719">
        <property type="protein sequence ID" value="VDM18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMT0"/>
    <dbReference type="STRING" id="6205.A0A0R3WMT0"/>
    <dbReference type="WBParaSite" id="TTAC_0000206801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000206801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000206801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="263"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000206801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50486" checksum="E29E734A2E59EE1F" modified="2016-01-20" version="1">MKPGDQAPEFFGTAVVGNEMKTIHINDYKGKYCILFFYPQDFTFVCPTEILAFNDRLDDFRKIGCEVVACSTDSQYSHLAWCNMERAKGGLGKLNLPLLADTNMEIAHSYGVLDRRAGTAFRGLFIISPDKKIRSIQINDNQVGRSVDEALRLVKAFQFTDKYGEVCPANWHPGEKGIKVRPEEINVTRPFGDSRLQKLVEQGGLPESRDVGTLPLCCIDRFSGLGGLRLGNQSKYSRRFAIFGDRGLSVNSRCLCTMAGVVAAVGKPAPGFTCRALVDGELKDVTLSDYRGKYVILFFYPMDFTFVCPTEIIAFNDRAGEFHQRGCQLLACSTDSAYCHLAWNNVTRKEGGVQGMKIPMLADTNHRISRDYGVLIEEQGVALRGLFIIDDKGILRQITINDLPVGRSVDEALRLLDAFQFTDKHGEVCPANWHPGSKAFKPNAGDLKAFMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMW5</accession>
    <name>A0A0R3WMW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2090</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000747">
        <property type="protein sequence ID" value="VDM18886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WMW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000210301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000210301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000210301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="425"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000210301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="684" mass="69539" checksum="0362EF27CF85D7D4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN30</accession>
    <name>A0A0R3WN30_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2155</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000805">
        <property type="protein sequence ID" value="VDM19054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN30"/>
    <dbReference type="STRING" id="6205.A0A0R3WN30"/>
    <dbReference type="WBParaSite" id="TTAC_0000216801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000216801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000216801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038545at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="6">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000216801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29559" checksum="2DC355F6FCD0CEB6" modified="2016-01-20" version="1">MLRNSVKFASPSLFFTLQFSCFLYRRAHARKALGKLDEAVSDLKRILDIEPRNSIALKDLGAWTGDSNLRAGSINSIFKIVDVSRVTSKALRPIQISEVGGTRSMFQANGCRELQPINNLTVSNVQDRSSDTALAPCVSPQLEVTPTMPLEPPTNWFQMERELRELIPSSESLAPLAVDYLCSIEPTNYASVIGNNLNSSCLGRFLAAFSISSKLTSAQKAERMAALAKLPRFDVAWLLTDDSDRTIVGRLLQEVPPESVASLKTYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN97</accession>
    <name>A0A0R3WN97_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional adapter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2222</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000863">
        <property type="protein sequence ID" value="VDM19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN97"/>
    <dbReference type="STRING" id="6205.A0A0R3WN97"/>
    <dbReference type="WBParaSite" id="TTAC_0000223501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000223501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000223501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000223501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="780" mass="85655" checksum="A88E8EEBB0A82189" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNA0</accession>
    <name>A0A0R3WNA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2225</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01000866">
        <property type="protein sequence ID" value="VDM19295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNA0"/>
    <dbReference type="STRING" id="6205.A0A0R3WNA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000223801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000223801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000223801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM19295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000223801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32163" checksum="55CE691C8D0BB94F" modified="2016-01-20" version="1">MPLKNRPLSTRHPKMHKYRHSPSFDISHSNESCGEHSSSEQDSPLSEDSKSVSILTAMWDFGQCDPKRCTGRKLVRLGVTRLLKQKESFHGIVLTPTGAQCINPSTDKDIVSRCGIAVIDCSWAQTDNTPFHRLRYRHGRLLPYLLAVNSVNYGRPHKLSCVEALAACLYILGWENEAHDLLSYFSWGPSFLEVNSELLSTYRACRDNAEVLRAQNLYMAQLEAKNNRKRCSYADVYADLNEEMGSDHENCKLEETENQGAGDNKSHDSQEVCVGRLDSLSCCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNX9</accession>
    <name>A0A0R3WNX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ApaG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2452</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001100">
        <property type="protein sequence ID" value="VDM20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNX9"/>
    <dbReference type="STRING" id="6205.A0A0R3WNX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000246701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000246701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000246701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5913487at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="2">
        <location>
            <begin position="199"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000246701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38098" checksum="B4D447CFC0A74851" modified="2016-01-20" version="1">MALEQFTNERQTVGAPTGPFRVAPIGQLQPTQKSPYEPGQLILHRLFGYRGVVLSSWKANVYEMKTYTPENDKSSDISEGISPSFKISAKCEQPMQAYAVLFDIRDAALSSPTMIAGVPFLLNGEGPCEATFNVTDMDYAFHEDLIPYTCTHELPLMNPSFMELMHFDPDVEPKVYPTDRLERILKKYGSLLEVQSVHQETTDGVRVTAVPFLMGRRKVSVSQQSCLWRYLILIENMTKRGMKLCGIYWNFSTPEGRPLNDYEADFVDTPVLPMRSPYFQYHGCLEMPNPSVRASGFFRLEDIDGISVIVGIPNLTFSDGEYCQELNAPNASSDDEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP41</accession>
    <name>A0A0R3WP41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion_trans_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2516</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001163">
        <property type="protein sequence ID" value="VDM20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP41"/>
    <dbReference type="STRING" id="6205.A0A0R3WP41"/>
    <dbReference type="WBParaSite" id="TTAC_0000252901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39102" checksum="1296FB15AF11CCCC" modified="2016-01-20" version="1">MLYAVIGIPLFFSYLSKNGDMMASLFRLAYARGCKPVFRMISRRRSRSTTKNGLYNSMQSLALIANLDAAVMRLHRKDSTNSNDSTNPDRNLSIHSTKTTHSDGSPSAEASKKPKSVRTCGKSKGRAPRPLKRSVSTKSFRDLRRNAVAEVGGRQTTENDSMLTIVPGGKLVIPPSSSLDSYNKPYRKFLSSGNDNISATNNANNNGSHLNGVKRKLIIHNVPKPSSEEKPVNVPISLTLCMMFIYILIGATVFCMWENPDYIKWSYFCFVTLSTIGFGDIVPGTKIDSENPKEKMIALVFYVAIGLSFFAMCFKLMQEEAMNKLRRIGQRMGILKRPEEEQAANLIETTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ11</accession>
    <name>A0A0R3WQ11_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2836</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001568">
        <property type="protein sequence ID" value="VDM21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ11"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ11"/>
    <dbReference type="WBParaSite" id="TTAC_0000285101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000285101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000285101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000525">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="72"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000285101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21817" checksum="47A3A35F9230AC7C" modified="2016-01-20" version="1">MADVVEIHGGNDFEDDTEGDHGIMRLKEQATKRKGRGFRGELVAHAQEEEFESLKTDDNASATGPQRSIEGWIVFVRNVHEEATDEDIRDKFCEYGEIKNIHLNLDRRTGFLKGYALVEYETFKDANAALQALNGSELHGQKILVDWAFVKGNSRGNGNSRRPGHRHGGSGNQRRVSRSRSRSHSRSRDRARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQL7</accession>
    <name>A0A0R3WQL7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3042</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001840">
        <property type="protein sequence ID" value="VDM21810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQL7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQL7"/>
    <dbReference type="WBParaSite" id="TTAC_0000305701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000305701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000305701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM21810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000305701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14417" checksum="8F10FC43717CE585" modified="2016-01-20" version="1">MQSWELVLQSHANRKAEQGGLLGSLERLQLDYVDIMLITRDPERICTVEEIVRACTFIVQQGWAFYWGTSNWPPNDIMEAHTVARLFHLIPPSMECMEFNLFQRDFHEYGLPELCAKLGKCTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQM6</accession>
    <name>A0A0R3WQM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3051</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001852">
        <property type="protein sequence ID" value="VDM21831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQM6"/>
    <dbReference type="STRING" id="6205.A0A0R3WQM6"/>
    <dbReference type="WBParaSite" id="TTAC_0000306601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000306601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000306601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8049355at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000306601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27014" checksum="63CA23A6B68C40F9" modified="2016-01-20" version="1">MRSVCLRIGITKPALNMAASNLAGLLKTTDLQCATAQTSAAFHVNLTFHPKHIRIDRLTEAHSIPQVESTEEPPKLITVTAGELLTLMCTAGPANPPVPLQWRQIICDDLFDANRSSTFGIPNTDANRAPCSIINNFGDARALPLLRSRMVSRSLVSLLVQARHHQSQVECSTLDSDRPNDRPNWSARSPEETTRLKKEITLNVLFKPNFSNVLSKLNPSTSKYLPQYITVEGQCLLSTDMIASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRS4</accession>
    <name>A0A0R3WRS4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PMI_typeI_cat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3450</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002451">
        <property type="protein sequence ID" value="VDM22654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRS4"/>
    <dbReference type="STRING" id="6205.A0A0R3WRS4"/>
    <dbReference type="WBParaSite" id="TTAC_0000346401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000346401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000346401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000346401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17525" checksum="4930498523841A69" modified="2016-01-20" version="1">MFQLKCASQRYDWGKIGQQSIVYALQVASKHPDTFHADLPYAELWMGTHPSGPSFLWDRPDIALEAYIQENPACLGNPCLHYFGRKLPFLFKVLSVAKALSIQAHPDKVSLTIVANRQMSYCSLCFKMSNLCNFRLAYDDGVFCLTSWRRAIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS60</accession>
    <name>A0A0R3WS60_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3585</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002676">
        <property type="protein sequence ID" value="VDM22921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS60"/>
    <dbReference type="STRING" id="6205.A0A0R3WS60"/>
    <dbReference type="WBParaSite" id="TTAC_0000360001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000360001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000360001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440745at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF7">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000360001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24489" checksum="BE03F722D3984251" modified="2016-01-20" version="1">MATDNKQPHENPYPPWYHSLHAYSRASDDLRRQAELMRQRGKAIRIESDALAKYYQLDVNNRLHDRIQCNREWLHMLLDLLNAIISVTQTLGDIKIQADQFLANLNDAMTVNVESLTHRDTRRDGDYVLDDVQEHLRKEAQLQKEIRDELQGIIDDAVVLLQTLIAIRREVEEAIDNKKKTIEIDVDVHNATEKSANISFKPFHERNVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT10</accession>
    <name>A0A0R3WT10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RIC3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3885</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003235">
        <property type="protein sequence ID" value="VDM23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT10"/>
    <dbReference type="STRING" id="6205.A0A0R3WT10"/>
    <dbReference type="WBParaSite" id="TTAC_0000390001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000390001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000390001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260562at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000390001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27360" checksum="9068B1FAA5EE3D53" modified="2016-01-20" version="1">MMTSEAPAPHWIHDCPESRLKWWFPLALTGAIYAVNILYILGKHLHKQLRPEPTPRCTAYPNIFRGIDHNSFDDDDQEFDFMEEEPYVKSKVFWVEESQWGSDDLRTPHTSTTTAVAFASLPEHGMNEDDDEDDETYPGRRVKQPENQINGENTKDNGIALQMNNINSVNAKAVEDAPQRKDGRHRIRQNQCLGEQNGHFFLKLRIFCEQMTSVSYPTGRFMVSQHLKGCIRWFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH8</accession>
    <name>A0A0R3WTH8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003569">
        <property type="protein sequence ID" value="VDM24075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTH8"/>
    <dbReference type="WBParaSite" id="TTAC_0000406801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10748" checksum="834F846C00A1C6B6" modified="2016-01-20" version="1">MFDCLEVYDKELPMDPVRLMHELYPDLKISEVECLSKNSASDNSNVASSGKREDVQVAGQRVRVMAKYKGQWLSGEGINVRTAKLKIAERLGIGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTJ7</accession>
    <name>A0A0R3WTJ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3694 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4072</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003604">
        <property type="protein sequence ID" value="VDM24111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTJ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTJ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000408701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000408701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000408701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-like" evidence="1">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000408701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24962" checksum="B5A524AF65AC83D5" modified="2016-01-20" version="1">GSFKKVPVIPSSDVKTGGIYQLRQGLNRRIRVLIRPNELSRRERGVLPLFCETVSKEYDLETVRHKWCNAMDEWQSYLQSNLQALAKKRDKEAVDEAKEGYLLNRWVSSILERDAILVPAAGSSLPGAPATENPPPGLEQHTPLIFADLGDGVFNKALKVGAHSYLEGEEAALKEGKAFVTLPLIKTYATLIGALASWDSNLHESDLLNKITPPSERIYLIVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUB8</accession>
    <name>A0A0R3WUB8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4343</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004191">
        <property type="protein sequence ID" value="VDM24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUB8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUB8"/>
    <dbReference type="WBParaSite" id="TTAC_0000435801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000435801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000435801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000435801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22794" checksum="8242E0087B2F6425" modified="2016-01-20" version="1">MMSWFKKPTLEDQLFDLKFTSKQLLNFSKKCEKEEKAAKAQLKKSIQAGNMDCSRVYAENAIRKKNEALNYMRMSSRIDAVAARVQTAVTTQSVTASMRNVVSGMSAAMKSMNLEKVSNLMDQFEKEFESLDVQSQVMEGTMSNTTSLNAPSNEVDSLMRETADEAGIELDLNLPSGVTSTIGAPSATVPAEEQDLSDRLARLRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUD4</accession>
    <name>A0A0R3WUD4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAB3GAP2_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004225">
        <property type="protein sequence ID" value="VDM24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUD4"/>
    <dbReference type="STRING" id="6205.A0A0R3WUD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000437401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000437401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000437401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019917at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000437401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="46183" checksum="6ADE699BF41E2881" modified="2016-01-20" version="1">MPKEYHQVKEKMKDIAEQLGSRTRPFWTESENGPCYIWPGNPNWVLKKLYSLADMSRGALWGTFTVSSDHRFGAITDDQSRITLVDLHRGVALRFWKGYKEAQTCFVDVTERFPPPGRQPRTAKFMLIYLPCSNNLEVWSLVHGPLLKCWSINGSLRFILPHMSNLKRTLKRFNALCAVENEHLVGIRLSLDLWFPHTSEARDFETFSRLRGWIRSRTFKASLKSSGLSIGIILLYLDFTTCIAKLEGLLANFILSDWFIKAVWVLLCTEMIDLSTWITEKLMELGDSFSLKETKRHAFLQYLKKICDLINFYHSFSRMHKAQTQNECEHSNESKHKLVESVAQFFPECGKVMGPFDFLQPWAFFRAAAFSNLFWMLPDRRRQDKTAAYEMLLVAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUK0</accession>
    <name>A0A0R3WUK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4425</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004381">
        <property type="protein sequence ID" value="VDM24908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUK0"/>
    <dbReference type="STRING" id="6205.A0A0R3WUK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000444001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000444001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000444001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000444001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18113" checksum="802CEFF8D78E3943" modified="2016-01-20" version="1">MSKILEVEFVYLPLGLPEVDHAKNLSVLEDVIGSFWGKSGPPFELANGNKQFMRLKSICESARLVGSVSAVQAAAESFLPFQLESVAELEVAGSACAKILQSVGSNADVSKIFPGPFTTSNFVLCAVVLLLNWFVITVFQATFYRFQHKRRHFVPKYFDWVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUY0</accession>
    <name>A0A0R3WUY0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4557</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004756">
        <property type="protein sequence ID" value="VDM25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUY0"/>
    <dbReference type="STRING" id="6205.A0A0R3WUY0"/>
    <dbReference type="WBParaSite" id="TTAC_0000457001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000457001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000457001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045773at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000457001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21603" checksum="024AF5CD27DD52A8" modified="2016-01-20" version="1">MDLPSPRSEEKAVLESIYTPEELSISDDYKIQFRLGTPGTLGSFVVNITWPKGYPFIPPVVDLDEFCNHHVPQSMRDSIIKEVNELASQNSGEPLTFTLIEHLRENMDEYAKQLKDFKKRSTNSTVKQLETEEAMVKRKTVEKEVLTKAQKRKQLDRLDEKGNLPRGWNWVDVVKHLRQTGAQANSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUZ7</accession>
    <name>A0A0R3WUZ7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">TTAC_LOCUS4572</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004790">
        <property type="protein sequence ID" value="VDM25211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUZ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000458701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000458701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000458701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM25211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000458701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36027" checksum="A2E0BC0A543B4562" modified="2016-01-20" version="1">MKISLGEGLQENFNKRYGSRGNDFSTLEDFSDRLNNFYTTLILLILVSITMTNVYFLRPISCTAPSAPSGGFGSYAESVCWVQGTIGLGKDDSFPSNESQWNELRQRADISFYQWVPFCLSVQAILFYLPHLIWQAMSVYTLGDNLNYLIAHAQTATASEDLGTRSKLVQACAHHLYLLSRQHMETRKSSFSRLQHKVLAFTQCASFCVFGKRLGNRTAVLYLLVKVLYIINCLGQLFIVMRFLGPDSTSQSSLRAFSERLFNLASRRQEWGGSDIFPLQALCPIRIPNLGVRSQLYTAICALPVNMLNEKIYLFLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXQ0</accession>
    <name>A0A0R3WXQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Innexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5525</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007841">
        <property type="protein sequence ID" value="VDM27156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXQ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WXQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000554001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000554001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000554001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000554001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25285" checksum="C9701FD51BB1E3C3" modified="2016-01-20" version="1">MFATWMECGGSHRVWKSDGLDRSIDARHCEAHYCSGGRVEVYEMRLTSTKRLISDAVQTLFCTTSLKCIDSECNASFVLFCVILGFIGICMLIPANVPILRFCDDESGIKCDLNVNNVEGLYNTHLLAMYARVDSRLTPLGMFVKHWAQNMDIHGADRGRLSTYALLLMLIHFLQCGCSPPVLPNLQARFPVSFGIGKAYSWLLHNMEGERHLSRWHYYPPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXT4</accession>
    <name>A0A0R3WXT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5557</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007985">
        <property type="protein sequence ID" value="VDM27221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000557401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000557401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000557401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000557401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10092" checksum="B9DEF8EF0EA94DFF" modified="2016-01-20" version="1">MKLLEVGGDPSATQYLFMGDYVDRGCFSMELMGSITSTVAISSTNSQIVVLLQMEMLVSTLYGAPPTLSSSSSRKLGFDVLQRQSRCGSSRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXV3</accession>
    <name>A0A0R3WXV3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008070">
        <property type="protein sequence ID" value="VDM27263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXV3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000559301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000559301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000559301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000559301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10247" checksum="B74B9F73563AA997" modified="2016-01-20" version="1">MAQKGWRMGDEQFIQSNQEASIRRAYYQLSMKYHPDKNPNGQAKFQAIKAAYNFLCERGLHSDGPNRRHIQLLIRAQSILYSRYRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYA9</accession>
    <name>A0A0R3WYA9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5733</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008805">
        <property type="protein sequence ID" value="VDM27554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYA9"/>
    <dbReference type="STRING" id="6205.A0A0R3WYA9"/>
    <dbReference type="WBParaSite" id="TTAC_0000574901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000574901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000574901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000574901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19561" checksum="126A2D8DB60A604F" modified="2016-01-20" version="1">MRLRLEYRLDLWSDLRVALNSQQHATKKIDVETKGGQETGKQSSQWYARQWLAFLDLHGLDLHHAMHALRRRLSLLESGCVSSETLLPPGVANVVTAKSSSEGIRLPNYWLPKRLTVITGWGSSSPRLSNRKPSSTLRHNVINFLHSSAYDFEEIPFSGSGKFEVRLRTKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYI8</accession>
    <name>A0A0R3WYI8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5813</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009172">
        <property type="protein sequence ID" value="VDM27711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYI8"/>
    <dbReference type="WBParaSite" id="TTAC_0000582801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000582801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000582801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000582801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10058" checksum="30343FE0E62C69AA" modified="2016-01-20" version="1">MPRTLPKFRATIEPPSPPLLQSTPLRSVEELVTAPLDTSLSVHQDDSFLNFAVAAEQQGSTGLVGPTRCLVVLGNSTSKFSDANVSGCWRCFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYL1</accession>
    <name>A0A0R3WYL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TMEM131_like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009292">
        <property type="protein sequence ID" value="VDM27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000585101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000585101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000585101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000585101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13702" checksum="BC98580E6430B11C" modified="2016-01-20" version="1">MPQECIPWLLLCRCGERQLENISIAIIPLILEDSPADSSFEEVEASGPLDSAWMPKSEMIVPPPGPTSPKRQSPPALMLAVLGQEVVRVDIPVMEPGISMFPGLEFTFTNVPRKSDFFCVYRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYQ8</accession>
    <name>A0A0R3WYQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5884</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01009554">
        <property type="protein sequence ID" value="VDM27883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000589801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000589801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000589801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ion transport" evidence="5">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM27883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000589801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13065" checksum="BEDBDCEAFD091623" modified="2016-01-20" version="1">MADDIILEPKLIAREYLRKWFTLDIISSLPLDYILLAFDNGTEQIAQAGQALKIFRLAKLLSLLRLFRLSRLLRYVGEWEKVSPGYQMLLMFVVFHFFQHAAGQKLSSLSVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYS1</accession>
    <name>A0A0R3WYS1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5896</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01009593">
        <property type="protein sequence ID" value="VDM27910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYS1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYS1"/>
    <dbReference type="WBParaSite" id="TTAC_0000591101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000591101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000591101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000591101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11018" checksum="A6E038874DBC26AB" modified="2016-01-20" version="1">MPCIEVGTVGGGTRLPAQRACIEMLDLSLERPAEHLARLIAGVVIAGELSLLAALATNDLVEAHMRLNRAAAAVAAATAGQPGAEEDENDRLGNTGLLLSNAKNFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYX6</accession>
    <name>A0A0R3WYX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Disintegrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5950</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01009884">
        <property type="protein sequence ID" value="VDM28028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WYX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000596601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000596601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000596601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133051" evidence="3">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="4">
        <location>
            <begin position="72"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM28028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000596601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14187" checksum="32BF3F9E131FB06C" modified="2016-01-20" version="1">MVLLTAVMLLLNKSSMHGPWNSVCLLTSALRVDLFLSYLQRFSPCSRRAIGRCLASRAVLCFEEEPFARLPLSQCGNSRVDPGEECDPGWRVGGAQKADPCCTSLCRLKPGAKCSPLNHQCCTLGRAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ23</accession>
    <name>A0A0R3WZ23_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010138">
        <property type="protein sequence ID" value="VDM28152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ23"/>
    <dbReference type="WBParaSite" id="TTAC_0000601301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000601301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000601301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000601301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8250" checksum="0F7A89D1174EB7A0" modified="2016-01-20" version="1">MPITTVLGDANARNWYDTASLFHHLIVLISIQHRSGLIIFTWTERTPASLTKTLLRSTTAISRTASIPRYVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZE1</accession>
    <name>A0A0R3WZE1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6141</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZE1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZE1"/>
    <dbReference type="WBParaSite" id="TTAC_0000615601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000615601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000615601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="495"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="688"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000615601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113081" checksum="8329A54CBBABE5C3" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZG6</accession>
    <name>A0A0R3WZG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6171</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZG6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000618601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000618601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000618601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055449at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF42">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000618601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16481" checksum="7C02508DAA8C25A0" modified="2016-01-20" version="1">MEFLGMHDTSSPNTQSSPPPPPLCASASPSLMPPHRSDKTDLRLRIKHAMNARERTRTASVNDAFLMLRRLIPTQPLNRKLSKIETLRLATSYIAHLNSILVTGIPASEQPCLRHHDVPYAGQRPSVCTFCVNEFKQRQKELEEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X042</accession>
    <name>A0A0R3X042_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6451</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X042"/>
    <dbReference type="STRING" id="6205.A0A0R3X042"/>
    <dbReference type="WBParaSite" id="TTAC_0000646601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000646601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000646601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="428"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="5">
        <location>
            <begin position="609"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000646601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="708" mass="78529" checksum="E540F2C33712F6BC" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0E7</accession>
    <name>A0A0R3X0E7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Repressor of RNA polymerase III transcription MAF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6587</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0E7"/>
    <dbReference type="STRING" id="6205.A0A0R3X0E7"/>
    <dbReference type="WBParaSite" id="TTAC_0000660201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000660201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000660201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000660201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29947" checksum="9493A1C167A43241" modified="2016-01-20" version="1">MKLLDNLQLETLTVRLSRCSRRYALDVKIESYSCKMVTEEKRQFKKLLAKLLDEGLQPSFLKLSSSRTLRGYRDLTGSSLDREAFRMSTFQAEPDVNPQSLSRSRNVSCYSEGGSADSQPKPSHPFISAKELFCLMSTITLSFDSTYDFLDKTSEDFCLEPELAIVRNYISHFCSIYVDKYEALAPKLWSTIDAEIVPHRCVIYSYKPNHSTDPYSRRCLASFNYFFFNRNLKRILFFSLCVLNETPVDDSYGDMQDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1M5</accession>
    <name>A0A0R3X1M5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLIP domain-containing serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7109</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1M5"/>
    <dbReference type="STRING" id="6205.A0A0R3X1M5"/>
    <dbReference type="WBParaSite" id="TTAC_0000712401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000712401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000712401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284740at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000712401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37181" checksum="803B3442FEB82D5C" modified="2016-01-20" version="1">MSPTLILGAVEVELGVVMASQCDKICSLDLLTIVAPRAGENHDLCALRGMRPSALPTLLLCFCFFFGPCAKVELFFAPNSTKMFNFRAGCAARHGCPEGYTRLMCTDFLNNVKVRVPFLRDMCFPSLQTCRLCCFESNCIDPTPGSDVRVSVMKDLLLQSGFYNESINKYLARENEIAQNRGVTTTTTRKTTTTMMSTTPTPTTTSEPMELCKSTPRTTPQEDFDPNEWTDEDELDSTTTVRVEDEGDLDSPDREVRVDEAEEVKKVESKTVAGERPDVQEMDMNDQTYNEEPSTRTATAVLWKASRDATTRSEVGIKSTLLIALLTAVGAIRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1V7</accession>
    <name>A0A0R3X1V7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7207</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020353">
        <property type="protein sequence ID" value="VDM31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1V7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1V7"/>
    <dbReference type="WBParaSite" id="TTAC_0000722201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000722201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000722201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="108"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="327"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000722201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60914" checksum="AE487CAB51A8B343" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3B0</accession>
    <name>A0A0R3X3B0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NPC1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7809</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020407">
        <property type="protein sequence ID" value="VDM32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3B0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3B0"/>
    <dbReference type="WBParaSite" id="TTAC_0000782401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000782401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000782401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252052at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133151" evidence="1">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Niemann-Pick C1 N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000782401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21216" checksum="C62B249E27F043E7" modified="2016-01-20" version="1">MLKSLLVGTVVLLLIESIKASCVMQGVCGKSTQHVCFPGNVPTVKLTDDVSSYCTQFKEGSDGCCTTEQIEMLSRGLKKVGFYFGRRSKCFQLMKELFCNFHCREDQSKVIYDIVPNSDNSAVSMTVEMKDKEAQDLFDACKDIKFLSVRVANRVCMRKPCDYREFIRSLGTSKANGGRAPMQINFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3S2</accession>
    <name>A0A0R3X3S2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">snRNA-activating protein complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7996</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020430">
        <property type="protein sequence ID" value="VDM32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3S2"/>
    <dbReference type="STRING" id="6205.A0A0R3X3S2"/>
    <dbReference type="WBParaSite" id="TTAC_0000801101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000801101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000801101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191169at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000801101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37539" checksum="A82A15E5C34F327D" modified="2016-01-20" version="1">MADSSYCMYTVNSPIFGLDDDLSLFLNEFVSIGSPRFSDFATLWKKWKFIELIYGRRTQSSLKDILEGIFFYLIKNFDDLSDLRKIGSIYTIYAFFGKQPIEKLARVNVTPSAWSMLSAAMKRIVTDRQWDAYYIFRRLCVQSAFRFVANEEELYPGVPLYTRSNISLPTRRTFLTKAQRKLLTIANRERNMRAGQRNVLPSRFLVFPEHLRTNWDAVLMATNNYIEEKARVSRVPETSTIRDRVANALKENTLWSLNLVSYEESVAPISKFLKQFSDEANQSCVDSTEADEEAELKPNDIGKRRRQLRNAKNWPPTRLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4K5</accession>
    <name>A0A0R3X4K5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8334</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020486">
        <property type="protein sequence ID" value="VDM32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4K5"/>
    <dbReference type="WBParaSite" id="TTAC_0000834901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000834901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000834901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000834901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="52216" checksum="5BAE4C6CD3CE69BB" modified="2016-01-20" version="1">MTTAAPSCTSFSIWLGKYLTHLSDEIDIEVYGDYIEGLLNDETLDKPEIIDSIRSFLESVLPSELAIEGSETIFTRFHDLQVTPSAQSPTTAATNTTASEHFDRLEEQMRSILISTVVANTTTPVPSYVNPFPPRNSSTKLTNLNTQGEKNQPQGKQESQLQKQRDACTVAVLRAAGATGYQGDAEAEAALKVALADAEYFAKQVANGGGISPSATTASKGGKTGLGVDVVAAAIMEREEEIDLEEIEEKQGYAKKEGIKPGNVMDALSTLNPGKFSSSDTAVAAAEDFKSSRHLKRMPTPGDVNSSSTPGYLLLNSRSTGSSVGGAANTSFIAGAGAANIPKKKSAPPSKHLADIGARAEEKHQRMMAKQQERLSAVGVGGTSGNRLDDMDAFFFSDDEDDVEARMRRTQQRKKEEDVLHADGGKRERVIEAEKLNRVISAREYAESRAKAKAERAGQEEENAKRKVVVHQRTQKLERRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X531</accession>
    <name>A0A0R3X531_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8538</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020525">
        <property type="protein sequence ID" value="VDM33112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X531"/>
    <dbReference type="WBParaSite" id="TTAC_0000855301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000855301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000855301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254420at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000855301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12930" checksum="84D505A33F824A0C" modified="2016-01-20" version="1">MSMLIALVIWGDTAVHTPTEMIEQRRMGLLRNYFRMLNADIYENHTALMHVVTDHIAAARNHLSDAFLMEAFQSLYLSWPFGVAVTAEIFLFTATVLYLTRKDFKAAPQQLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5X2</accession>
    <name>A0A0R3X5X2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8873</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01020615">
        <property type="protein sequence ID" value="VDM33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5X2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5X2"/>
    <dbReference type="WBParaSite" id="TTAC_0000888801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000888801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000888801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000888801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="356" mass="38944" checksum="3E40375F646E1588" modified="2016-01-20" version="1">MRVVRLLVRTACHRTVRSVCGTRYTGSCSVKMTIREGSAFINLPEGVFYNPVQEFNRDLTIAVVKHYAKKHFEEFINKGIKKAGEKGAPEPVTYSGLSVLEALSASGLRSIRFAKEVPLLNKVVANDLDPNAVRLIEENVRLNAVGDSVVPSCADAVGLMHDSVKNKFHVVDIDPYGTAVPFLDAAVQCLFDGGLLCVTCTDMAVLCGSAAGTAYGKYGGVAIKMAAQHEQGLRLLLHAMQQAASRYDRVIEPLLSLSIDFYARVFVRVRTSPSRVKRIASRLAIIYSCTGCQVGLFLSILFFMSDDHRFWLRPLQSDGSICPITLHVVVIEVAMLSSGMKYEGSVINLVVLNVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X628</accession>
    <name>A0A0R3X628_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8931</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="UYWX01020630">
        <property type="protein sequence ID" value="VDM33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X628"/>
    <dbReference type="STRING" id="6205.A0A0R3X628"/>
    <dbReference type="WBParaSite" id="TTAC_0000894601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000894601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000894601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="338"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000894601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53371" checksum="E160E90531C36EE5" modified="2016-01-20" version="1">MTKSQNVKVDRICCVGAGYVGTPTSAVIALKCPEIQVTVVDCNAERIAAWNSDKLPIKEPGLLDVVKACRGRNLHFSTDVNLHASEADIIFICVNTPTKNYGIGMGRAADLTTLEAAARTLASCFTTSKVVVEKSTVPVRSAARVAELLNLQSPSHLDHTVLSNPEFLAEGTAIKDLLYPDRILIGGDESSAAGRRGLEMLTWVYKHWIPEDRILLTSVWSSELSKLAANAFLAQRISSINAVSAICEATGADVREVAMAISRDTRIGPFFLQASLGFGGSCFRKDILNLTYICESLNLPEVASYWNMVLRLNDHQMERFSRSIVRSMFNNLRDKRVAIFGFAFKKDTGDTRESPAIRVCSILLSECAYLAIFDPQVPAQQIITDLNEASSPDLVRANVTICRNPMEAAVNSHAIVICTEWDEFKNLDYQHLYDVMCKPAWLFDGRLIVDHRLLKKIGFHVKAIGIYLNDDKDNSQPPLPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6C6</accession>
    <name>A0A0R3X6C6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9038</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020662">
        <property type="protein sequence ID" value="VDM33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6C6"/>
    <dbReference type="STRING" id="6205.A0A0R3X6C6"/>
    <dbReference type="WBParaSite" id="TTAC_0000905301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000905301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000905301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000905301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="20982" checksum="617227029123F348" modified="2016-01-20" version="1">MEEYAREPCPFRIISDCGAAFAMGTIGGGIIHAYKGYRNSPSGRFRKLSSAIAQSRMKAPLLGGAFAVWGGMFTAVDCTLVFVRKKENPWNSIASGAITGAALAVRHGPTAMAGQAVIGGIILAIIEGLGIMMSRFAPMLMQQPETPVEQPPLSEGGRGGGFLSSLFSGSTGASETNINQSTVPAPSCDSQPSTSGRFMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6K1</accession>
    <name>A0A0R3X6K1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020687">
        <property type="protein sequence ID" value="VDM33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6K1"/>
    <dbReference type="WBParaSite" id="TTAC_0000913801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000913801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000913801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248775at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000913801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40070" checksum="C9FF56A0E8436C15" modified="2016-01-20" version="1">MDSSQEGPIGNMESDVAFSLKSVPSSKVSYRVAHIDIVPSTFFITPKVDQYLRLCAKNLSEFISKEFPDISVSVTYLQGTHDRRSSDIVKFQVFSNPIWWKCLPPFNVQDRYSAFIKGGEEMSPFGCTWRSILKIRRLFESLRSRLAVIPCLHLGLCPADDQRFNEHQSEACHQSNNWPLNLRLGVSTLNSKAKSLLATPPSLFWAFAVALEFYCLQSKGQKDQGSNTNLTEETVGVLENWMNFMTYGTLFKEDSERYSYINKNLLRTTTSSAQCTSLWPSPLAIVVECFGMEDPVQSTDEVDEQLSTLETAWCNAVQNSIMKGHAIVLREVDIDQMKEAVAHKVIETCKMRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X720</accession>
    <name>A0A0R3X720_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020759">
        <property type="protein sequence ID" value="VDM34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X720"/>
    <dbReference type="WBParaSite" id="TTAC_0000933101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000933101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000933101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283775at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000933101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="217" mass="22598" checksum="7C3D5DA9B3BD7084" modified="2016-01-20" version="1">MPGPELISLTPKGHTKVDVTMTVPRDWDEEDVLVAYVAGAAEKNCTGKNNVSVCTIGGLLPRIPYNVCARSCHPNATATTAVSDSSGGAQLSSSVDLFRIGTVEANDALICSNAVCSSVTIPIEVPGLFSMTPKGHTEVNVTITERTDWDKEDVLVAYVAGGAEAKNCIQDNDTKECIIGGLLPRIPYNVCARSCHPNATATTAVSDSSGGAQLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X782</accession>
    <name>A0A0R3X782_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9388</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020793">
        <property type="protein sequence ID" value="VDM34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X782"/>
    <dbReference type="WBParaSite" id="TTAC_0000940301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000940301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000940301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000940301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14056" checksum="FFD7DD235A7E3CFA" modified="2016-01-20" version="1">MLSTFSRLKAVQDLNFPAQITEPNALARLQKRPLYGLSFELKATRFLIGCSVRKKIEKEIMRLDCSFYSSSDGGFDCHADDGGGDAGVSVVVVIVVVDNDGDNSNCGNDCSDDGDGVDDDDSLGLGEVTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7J1</accession>
    <name>A0A0R3X7J1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9501</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020851">
        <property type="protein sequence ID" value="VDM34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7J1"/>
    <dbReference type="WBParaSite" id="TTAC_0000951601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000951601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000951601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000951601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18516" checksum="B21ED6BF975E0222" modified="2016-01-20" version="1">MKKGMASEVLAVMPPIDRHEVCEGSKSTHVVALDLRVSKSLQIGFSPPPLTVLISPLVSLFFLTTNLSAKSFRSLSHQVDEEEEEEEKEKEKEKEKEKEKVKEKEKEKEEEEEEEEEEEETIDKQGSRRYCKQGIKESNVYLTPISALLLCCGGPGSIPTSKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Y8</accession>
    <name>A0A0R3X7Y8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9648</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020958">
        <property type="protein sequence ID" value="VDM34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Y8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Y8"/>
    <dbReference type="WBParaSite" id="TTAC_0000966301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000966301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000966301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000966301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10611" checksum="88ECBC201ABC119E" modified="2016-01-20" version="1">MSRNVTGERAVVRNSDMDESMQSLAIELAGAALEKYTIEKDIASHIKKEFDRRYGPTWHCVVGRNFGSYVTHEVRNFLYFYVGSLAFLLFKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8I0</accession>
    <name>A0A0R3X8I0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9840</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021095">
        <property type="protein sequence ID" value="VDM34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8I0"/>
    <dbReference type="WBParaSite" id="TTAC_0000985501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000985501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000985501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10468216at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000985501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31167" checksum="D5A9E6455ABEC24D" modified="2016-01-20" version="1">MPSQLSTPFHLPLSPHVHEEEVRDHVATTELTCIPRRPPLLSSDPLFFFFFSSSSSSSQYLPASHATFVFAYFVAIILVIVCVGDAEDTKKNGAESPQNPDCHDTADIPEPCVDIETNNEVAFVKPPQTLNNRRLNAIEEDLGDLKEVRQLGDRRLHKELVAKSQSLKEMEEKFVKVSAELETNVVDAKAKNKALEDILRNKQEVLQRVTAERDAMRKAKCTLALRLQVAEDQLRDVEHKLNSRVLGVEMEKARLSETLEGVRTVTETAEEVIARIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X992</accession>
    <name>A0A0R3X992_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10103</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT57 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021312">
        <property type="protein sequence ID" value="VDM35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X992"/>
    <dbReference type="STRING" id="6205.A0A0R3X992"/>
    <dbReference type="WBParaSite" id="TTAC_0001011701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001011701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001011701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423881at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019530">
        <property type="entry name" value="Intra-flagellar_transport_57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011">
        <property type="entry name" value="IFT57/HIPPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10498">
        <property type="entry name" value="IFT57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001011701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31202" checksum="DA5A896EA750F067" modified="2016-01-20" version="1">MLALARTSMSLGEVLIRDAYIVSNIPLSRVFFCSAFFRMEGGKLEIDEHDETTQAAVTSIVTHANLPQSLFLPFQMMESLLEKLKLLDYEQFYCSRNRIKGFSKLYFVIPTNPGEQFNAFVGLATWLINEAGFLMEIPQEYDDPNATIANILDSLRSLVGQAPEFPPSKLKSGCGDYCIHVLDLLADVAIKHKCTVFELPRLDERDDTEGGASIIENATFSASEEGDLVEWTGNKVCVDGTRSEIRPGIICDSEMDVDSDNDENDLPAASAERKIENAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H6</accession>
    <name>A0A0R3X9H6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arf-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10186</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021402">
        <property type="protein sequence ID" value="VDM35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9H6"/>
    <dbReference type="STRING" id="6205.A0A0R3X9H6"/>
    <dbReference type="WBParaSite" id="TTAC_0001020101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="389" mass="41418" checksum="58F01B6897AA6778" modified="2016-01-20" version="1">MWRCFACGKIYLALCNGKEPDERNSNFDDYLRLKYQVQKWYRVPDPAVEEEAFRENEEALSRASQNSSAKASHISANAAAGLIILSNRSLPTSLSKPSTSNQTPSETASDKAGSSSPCPVVAPSITAQQQQKASLFSVSSRVVFVVYKVVVVLLLSFSCSKLFSCRRLMQVNSCIGTTAEKDSAFSDPFAEFVAARPVAAASQTSNQSSLPASLAYTSPTSSSLQSIQPAQPSSSSVAYKLPTFPPSSSVSMVFPATNPSVSSSPFGVSGFGTSSAPVDKYAALAELDRMGKLGECAQASRSPVAGSFSSVTLAPLKTQQSNPFAPSLTYNPFQAQTLSTRNPFAMMNETGTPVMQSNTLPVPKPTNISTSLGQSSFNPFVVSRPSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9I0</accession>
    <name>A0A0R3X9I0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8 kDa glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021410">
        <property type="protein sequence ID" value="VDM35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9I0"/>
    <dbReference type="WBParaSite" id="TTAC_0001020501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001020501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001020501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008860">
        <property type="entry name" value="Taeniidae_ag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05596">
        <property type="entry name" value="Taeniidae_ag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133347" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001020501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9607" checksum="C03619E21E2541D6" modified="2016-01-20" version="1">MRAYIVLLALSVFVLTVSAEDDNSEAIAKSAKKAMECIYKFFTEDPLGIKIVKFAKSWKESMLEARSKVRARLAEYIKTLKSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Q6</accession>
    <name>A0A0R3X9Q6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10266</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021488">
        <property type="protein sequence ID" value="VDM35246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Q6"/>
    <dbReference type="WBParaSite" id="TTAC_0001028101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001028101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001028101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001028101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19824" checksum="33A46A4947B46AE6" modified="2016-01-20" version="1">MKQHVPASRLDDAELVFIAEFGECGDMHYDEAMAVECFTLPEYDLRSSDPMVEDAAMLGRVECAAFNSKFYISSSSTSSSFFFFFFFLFFFFATSYFASASVFLLLDMAQASPSDLSDSNIRNVANTQHHMDLHESIPLPPNDAPPLHECSATMECPGTNGDQLATTTHVLQSKQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA44</accession>
    <name>A0A0R3XA44_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS10404</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01021660">
        <property type="protein sequence ID" value="VDM35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA44"/>
    <dbReference type="STRING" id="6205.A0A0R3XA44"/>
    <dbReference type="WBParaSite" id="TTAC_0001042101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="10">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53438" checksum="FCC559191C5A5F76" modified="2016-01-20" version="1">MLTVFAKAFAIVCASWAALGSTNITYTPDWASLDARPLPSWFDESKVGIFIHWGVFSVPSYVSEWFWWYWQGNPPNPQVWVYMQTYYGSDFAYPDFAQNFRAEFFNPNHWAEIFNASGAQYVVLTAKHHEGYCNWPAPFSWNWNSVDVGPRRDLVGELANAIRTNTNLRFGLYHSMFEWFNPLYLADKASGYKKQVSMPELMDLVNRYRPSVVWSDGAPATSDYWKAKEFLAWLYNDSPVKDEVVVNDRWGLDANCQHGDFFNCEDRFHPNKVLSHKWESCITLDRYSWGFRRESRLDDYLSPEVNQMFNLHELIENLISVVVYGGNLLVNVAPTSWGTIPPIYEERLLTMGQWLKTNGEAIYKTTPWKYQVDSKREKLWYLQKNATEPNPVVYAFFADWPSTQVKATNDVSKFTLLDGKDGTTLSYTLSDNNNCVSVHLPPTQPDGSFVAWAIRMENVQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA91</accession>
    <name>A0A0R3XA91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10451</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021714">
        <property type="protein sequence ID" value="VDM35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA91"/>
    <dbReference type="WBParaSite" id="TTAC_0001046801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001046801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001046801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001046801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8266" checksum="920A9AC593B1A631" modified="2016-01-20" version="1">MLGGSKKPILELRVLPQLRGKYNTTNKQLNVTAKMRGAYSVSGEFDARGEGKRERVGTYIFLVGVLMKSFESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAD6</accession>
    <name>A0A0R3XAD6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021767">
        <property type="protein sequence ID" value="VDM35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAD6"/>
    <dbReference type="WBParaSite" id="TTAC_0001051301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001051301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001051301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246200at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001051301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24190" checksum="794B75E40D509CC7" modified="2016-01-20" version="1">MQKMRRYDIENELRRRLLLLFPPSQSRVDPEERIKIVVFGLLLDTISLESEEEMDTCLSILSNDTHLLAAVKAVLISASFTGGMGGHLTEAMSLKVLHHSNAVRLLAKLGVPKAEFYGVHCATFNNIGHRRKSMSVDLYIRQFLPKFIRSIMNTSERFMLYALLYPIALTLFQPRNGAQCHFRDRIVASVVKGNVELVRPLRKTPPNEVERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAV7</accession>
    <name>A0A0R3XAV7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin_16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10667</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022020">
        <property type="protein sequence ID" value="VDM35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAV7"/>
    <dbReference type="WBParaSite" id="TTAC_0001068401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001068401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001068401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042360">
        <property type="entry name" value="AIMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041503">
        <property type="entry name" value="AIMP2_thioredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13438">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13438:SF2">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18569">
        <property type="entry name" value="Thioredoxin_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIMP2 thioredoxin-like" evidence="5">
        <location>
            <begin position="355"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001068401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="547" mass="59588" checksum="9828AD85A0565C38" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAZ8</accession>
    <name>A0A0R3XAZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10707</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022096">
        <property type="protein sequence ID" value="VDM35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3XAZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0001072501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001072501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001072501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034649">
        <property type="entry name" value="Hip_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883:SF2">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18253">
        <property type="entry name" value="HipN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Hsp70-interacting protein N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="STI1/HOP DP" evidence="5">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001072501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30169" checksum="9E6248AFC2B7E6C7" modified="2016-01-20" version="1">MLPPQLLRDAERFVGILKGDPDLLHTPELRFLKEYLESEESELGNDLHFLFTSCSYEEFDTSGVIEEEPDEPQPMGDDTAEVTEEMIEKAEEKRSEAQAKFSDGDFESAVTLFTESILANPRIAVSFAKRAANPHLLFVIAISGAVLPISEALGHWEEAYMDLQTSLKLDYSDDAYDAMKAVEPNVGSVISPLRLQDAFSKILSDPELIAAMQDPELQAAFAQGLTNPAAFNAAASNPKFADLMKKVGKKMGVPEDAQAAPASGGPQMKPTGDGMCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBR3</accession>
    <name>A0A0R3XBR3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH dehydrogenase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10973</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022636">
        <property type="protein sequence ID" value="VDM35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBR3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBR3"/>
    <dbReference type="WBParaSite" id="TTAC_0001099001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001099001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001099001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281863at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001099001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27716" checksum="F31EE1610B3D76A9" modified="2016-01-20" version="1">VCFEVYYSVWSAFSFSGIGVNVFGFILFYLFWICIKVLFISIFVVGISVSVPLIYKIRVCIGILYSSIYLLLIWRIYSFSEQFFLYKLASGERKILGYSQYRKGPNKVSFLGLFQSFADLLKLIVKFKWFYFQSRNFVGLIGVMLLVLLSIFYCFVYGNYYGSKIGILCETNRTPFDYGEAERELVSGFNFEYSGVILFFGDSIFSMILLFINLLFFMWARATLPRVRYDFFVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC34</accession>
    <name>A0A0R3XC34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MG3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11094</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022944">
        <property type="protein sequence ID" value="VDM36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC34"/>
    <dbReference type="STRING" id="6205.A0A0R3XC34"/>
    <dbReference type="WBParaSite" id="TTAC_0001111101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001111101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001111101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macroglobulin" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001111101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46328" checksum="3FC710C9E5C9A44C" modified="2016-01-20" version="1">MDGNKSIIEERYKYDLKYCVPIEVKPGSYFNLQITYFYCPSKICTNVDELMHKSVTKTVQMVQHFVVIMGETDKPLYRPGEQVRFRLIALTSRHILPYSELTMWPEYEAVSESSAENVLKRIDPGERERRMEAPHFDLIEIKDPLNNILYQWKDVRPLDALNLVYKLIRDAKEGEWKIEACVRHQKEVVFFNVRHYVLPLFRVHVELPGVIDLSRSDVKIGVCAAYINGPLIRGTYDAQICICDGSVLKRQQVEARMFPRNKCVANSSPVVRLCTRVNGILDDVSCTNITVDTLHLVKDKSASWNERLAVFVEVVEEGTASSVFSSGITELRTLEESQIELILPDAYKNGLPTAGQVIYKNMLNKTDDKVEVVVREIPDKCDYYWRFKKDTFTTITKVSVKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC80</accession>
    <name>A0A0R3XC80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023047">
        <property type="protein sequence ID" value="VDM36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC80"/>
    <dbReference type="WBParaSite" id="TTAC_0001115701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001115701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001115701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001115701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9306" checksum="3478DBC8B3D2BB69" modified="2016-01-20" version="1">MRTVVFIVADGGGGGGEKDDLTVDAIATTALCANEVMRKAIQNCEVANCGALAVVEAVEEKKWKEEKEEEEREECMECECVPCHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCT1</accession>
    <name>A0A0R3XCT1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11341</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023709">
        <property type="protein sequence ID" value="VDM36321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCT1"/>
    <dbReference type="STRING" id="6205.A0A0R3XCT1"/>
    <dbReference type="WBParaSite" id="TTAC_0001135801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001135801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001135801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001135801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16920" checksum="B895CC32523861D3" modified="2016-01-20" version="1">HSQRIHFSHPPKFKYTHLFRPQETPLLFRIPTPLSGRSDYCIQVLCCIVGKIMVNFIIPFGYGTHICSLAVRIEPHLFEWLGWYSGKLPNFLSPTTLNELGYNVDREYQSLSSLDQLDLQESVPQFYARSTQLVNDILEHNPTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD14</accession>
    <name>A0A0R3XD14_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS11424</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024119">
        <property type="protein sequence ID" value="VDM36444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD14"/>
    <dbReference type="STRING" id="6205.A0A0R3XD14"/>
    <dbReference type="WBParaSite" id="TTAC_0001144101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001144101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001144101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM36444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001144101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46851" checksum="8CF109EED5C058DA" modified="2016-01-20" version="1">MSDTVGTPRMFKPCEWLCSNRTHYGKADAVRESARNVALENNVLMKEIKERTLKTMQDVDEKLDQRIIDTSFWMSELTKKLKDNASETDKLNSCIVRLKKALEATTEPLYLSEKCITIRQDRKGFDLVADNAHNELVKEITVLNGIRALLTRGIEQAEEQLRGSDRLNRRSAFNLKLDFCGKEAAKNQDEYAKTVSSFDYIPEVNKCHPNSLSTDEWLLYLKKNIEEADRQIRNSRQTRSLVESVLEQVFEDQKDQVEATNQAIRTRIDETRDAKRKLEEHLSLIFKETSDMEENIRNIEKLICDTLKSAQITETKKNIRDCRPSNELCRDPPHYRIIEQTKELKADISTLQQMLHDAEEELKALRRRQLDLEEEIQNKSHSLHIEEVQVLEIRSSILVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD36</accession>
    <name>A0A0R3XD36_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIY-YIG nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024226">
        <property type="protein sequence ID" value="VDM36527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD36"/>
    <dbReference type="STRING" id="6205.A0A0R3XD36"/>
    <dbReference type="WBParaSite" id="TTAC_0001146301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001146301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001146301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8957441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001146301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8339" checksum="573DFFB8734C2B94" modified="2016-01-20" version="1">MSPILSGDNSPSRQRRGWLDQSVNVAAFVREQPFPLWANVYGVVFGKRGEFYAIGRIKASCSLQVSLSINPQNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDB5</accession>
    <name>A0A0R3XDB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11525</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024662">
        <property type="protein sequence ID" value="VDM36837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDB5"/>
    <dbReference type="WBParaSite" id="TTAC_0001154201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001154201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001154201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001154201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12495" checksum="E52A7E1379624ABE" modified="2016-01-20" version="1">MDPTVSHNPLLRFCDFSQPRPPPPPPGDPARRAPPSRLPTGQGCVCKFAPIYANPTHYHMIVLVKGIVAFTTTVLLVDPVVYASIHTSPRWMPQHDRWCICWPKKYCTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDI4</accession>
    <name>A0A0R3XDI4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11594</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025420">
        <property type="protein sequence ID" value="VDM37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDI4"/>
    <dbReference type="STRING" id="6205.A0A0R3XDI4"/>
    <dbReference type="WBParaSite" id="TTAC_0001161101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001161101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001161101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001161101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12958" checksum="275B2EADA7FC5B86" modified="2016-01-20" version="1">MNPLKAVGSAIISVPDTLFDGFSKMISRRQPSDVNGNVQTTTASTNNTNSRSSTLSDTTSNLSILDQVTDLWSRGVNSYRRIILTQSYMFWGKGEEFILCLSFLSIFEKRFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDK0</accession>
    <name>A0A0R3XDK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acidic leucine-rich nuclear phosphoprotein 32-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11610</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025674">
        <property type="protein sequence ID" value="VDM37341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001162701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001162701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001162701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133388" evidence="2">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM37341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001162701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18196" checksum="731D53CD02F7BC0F" modified="2016-01-20" version="1">MRKLRSYSIFVAVFGLCLTPTGKQIEMDTASQMNEEDDCDYDYEYDCHYYDYYEEADYDEEEEEEGYANDDKFGEGNKDEDMLKDLDNEDFEEMEDDNDGVEENRPAHKLVGEKHGPPYWERERDDLEGDSPKRDFARRALHLSIHYLHXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDM8</accession>
    <name>A0A0R3XDM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11639</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01026273">
        <property type="protein sequence ID" value="VDM37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDM8"/>
    <dbReference type="WBParaSite" id="TTAC_0001165501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001165501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001165501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001165501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="52" mass="5721" checksum="AD6473605D135CC9" modified="2016-01-20" version="1">MNHRLQPLTRLHVPCRHAPPPPPPPPPPPPPPSPYPSLLIPDRTSASTIMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE27</accession>
    <name>A0A158RE27_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6516</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE27"/>
    <dbReference type="STRING" id="6205.A0A158RE27"/>
    <dbReference type="WBParaSite" id="TTAC_0000653101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000653101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000653101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="363"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000653101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="677" mass="75238" checksum="CA13B853E7A79F63" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE42</accession>
    <name>A0A158RE42_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FGGY_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6577</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020309">
        <property type="protein sequence ID" value="VDM30807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE42"/>
    <dbReference type="STRING" id="6205.A0A158RE42"/>
    <dbReference type="WBParaSite" id="TTAC_0000659201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000659201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000659201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000659201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50180" checksum="F8D59F9E8B90930A" modified="2016-06-08" version="1">METEASLILGIDLGTSSIKVALVTQGPNPHVETTLSRDTGLVSGHSLSNFKIFYLPNEHTQDVGKIFQCLHILLSTIPPRLMARVTAITVTGQMHGVMGWLGSDLAILEKSRTEKKKLDANVSGGGCGKLITWMDRRCSKEFLDSLPNPTRSEKPFTGFGCATILWHFKNQPEEFAVTPIDVEQERDIFEKAAVLRKTSVGSPTQRPTIIGNADDCKSFASQTKSRSISQSPLPSLFRPVQHTPWTCIGTVADFLVACLASLQRPIMSPQMAMSWGYFDMENNSWDFHALNASGFTLTHLLPEIVPCGTEVGKLAFDWEGVPAGAKVFVALGDLQCSVYPFLEHQRTLNGIGACNISTSAQIAFKLPAGVEINAPTSSHSSPTSTCNADSEGVFERLLTSKRISVWPFFHPNERIVVAASLNGGNVIERFIKMLRVWCRQLGCPAIETAQVNLFNGVGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REX9</accession>
    <name>A0A158REX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8282</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020477">
        <property type="protein sequence ID" value="VDM32807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000829701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000829701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000829701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000829701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="37809" checksum="767326EF74AAED3F" modified="2016-06-08" version="1">MNVGGERALMYFACCNSDLAMQETDITLVASEVCESLLTNPLGEMSGWEDIWIHAGQSPVTPPQVCWRRSSFCSAWHTSTATLASPYSLLQLNVLYIEGEERPKPRGSRVKISSETHATINLTHSTWQKRLTILASPRSGLLQVSTACQRHVRPTRLLTVVCLSTDEVDLRTSFRLSQFVKGEATPQIDFAVKGAIVTHFHFRIISDMVKNTTSDLSVFHAAFLPPNKEDFDLLIWGTSTSVLMVPVKFNQSDECTKPLWLTHQVNMLFVFVAVFVGGGVVVRFRHGDDIVGPSTSSPHFGGLALTNRASVPGVGGTPVSATKTWKNELNHGAAAQANLSLCPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E008</accession>
    <name>A0A3P7E008_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS80</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000005">
        <property type="protein sequence ID" value="VDM15801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E008"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF2">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="215"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="338" mass="38532" checksum="CBC1E6F223CB3781" modified="2019-02-13" version="1">MGGGWRSLASLKSSTEAELRTLLPPGKGNRQVNEELEAELPVFYRRPWPGPTCPAFFREVFVCYKYIARAFSKGAAAKGLQVGFSNSAKSGQLFKKLRDSAQFVPRLFEIDCTTNTLKYYIKLTNTDPKECIDVERCNMTFVDCEAFGVPSNTALIQFVQDHSTRHIFVRSEDSREILNWYNTLRLCKYQRLRLHLSGTGQKVSMDEIVSYLTSDLEKVGWLLKGGPDASYTFRRRWVMLTKRWLLYTLTPQSAFAKGEIFIGSSEDGYSVESKAPESWKKVPTDFPITLITPDRSFVFCAASEEERDYWLCGISAIIERPVTLLEAKEAAPVFNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E912</accession>
    <name>A0A3P7E912_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000790">
        <property type="protein sequence ID" value="VDM19021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E912"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF37">
        <property type="entry name" value="HOMEOBOX PROTEIN SLOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="252" mass="28075" checksum="EAE0AFFEA05DD79A" modified="2019-02-13" version="1">MLQQQQQQQTSCLNLASLLALQESEYFQVARSDPNFYTAATLQKQQQQKHPNQIMRTGEGEDTHAVSGSAVVGGAGKHRRARTAFTYGQLVALESKFKTTRYLSVCERMNMALSLNLTETQVKIWFQNRRTKWKKENPSEQHHQTSLNSRKQINTQEQPILPGGLCSNHSEASDMSPPNSSITESPPARDQREDSTNAVLLAYVFNQLRNSLHKDKNSTADGILQAFATNVTTTTSRSSKSESDQVGLDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EW24</accession>
    <name>A0A3P7EW24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008695">
        <property type="protein sequence ID" value="VDM27511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EW24"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="64" mass="6858" checksum="E47AAB9D8B0604DA" modified="2019-02-13" version="1">MKLSEVVLVSPMLVNFPDTVVEQSSTMDVKVANRGLSGTIWVVKSSNATTGKKRGLSEGCTPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZX2</accession>
    <name>A0A3P7EZX2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002069">
        <property type="protein sequence ID" value="VDM22154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZX2"/>
    <dbReference type="OrthoDB" id="6261690at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="388" mass="42133" checksum="C60F803849D64834" modified="2019-02-13" version="1">MDAEEGASLSEKENPLSRFGLSPVECVHQLLNAVVFLHSNSIVHRDIKPSNIFILEATSSSASSPSSDTTTTAAAVNRLVLGDFGLSLPLENGFFTNTICVEPSNTTSTTDDGGWPTTGASGAFTFGSLGWMAPEMCASSNEALTQSVDVFAFGLVAYFILSLGGHPFFSPLEAVSSSKAREAVPARPRRLREVYTSLASLQSMQKAINDLQAPRLNNLENCVRVVMTAGAETNEEKPDKMRSCLAQQLIQEALSPDPSSRCSIEVLAGSPLFWTAEDVMAFYTEISNFMDESKPLKFASGSGSFHLTTERTRPVEGGDEVAVIVSSTDVFHSIRQRLSTALDEHWGNVFSGSWLRHLDTVLVDDLCSVRSYQVFLFTNIFSFCFAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FDU7</accession>
    <name>A0A3P7FDU7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FDU7"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="293" mass="31797" checksum="4023DF7BF5E1B9CD" modified="2019-02-13" version="1">MFSLSSSSFESLLSFSFREGYIQTSQMVPAQTLLQPLQQQLIVDPNGTAAGQQPTFAFQASDGSLIPVQLAASPNGGPLIMLMPTQTTGQGGQPVYTTQAITTGATAATATIDAAGQATVLGSTVEDENNQAAALQQQQTQQSTGQVQLVHQQTVTATQAASQLMQQTAAQQSTASMAGVGQEEPLYVNAKQYNRILKRRQARGKLEAQGRIPKERRKYLHESRHQHAIKRVRNAGGRFYSAPTSNLHRGSSVMAILWFSVRFIPQIYLQSCLFLLTTQIRRVASLLLLSDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FE92</accession>
    <name>A0A3P7FE92_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007935">
        <property type="protein sequence ID" value="VDM27204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FE92"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="81" mass="9052" checksum="CBCD5BB977A411AA" modified="2019-02-13" version="1">MSVEDDPNWYLAEQDGRKGLVPCNYISFRPNPWYMQACPRNTAEECLLETDPCTGLPVQPDGAFVVRRSESNGPGFSLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FF74</accession>
    <name>A0A3P7FF74_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008481">
        <property type="protein sequence ID" value="VDM27409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FF74"/>
    <dbReference type="OrthoDB" id="10052517at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000160">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="108"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="250" mass="26689" checksum="35CA853FEC4AE74F" modified="2019-02-13" version="1" fragment="single">MMSLVPPGAPNGLEVADVDAEEVTLTWIKPRQDGGSKITGYTVEYKPASSDEWIKAPVTKDTTATVSGLRKGEKYTFRVSAKNSAGTGEPSQATRPVLCKPKYDAPDAPGQPRVDDVDKDQVKLSWSAPLRDGGSKITGFVVEKKKLGDDDWSKAATLPPSATTATVDQLEPNGEYEFRVRAVNAAGPGEPSLPSELRKIVPKQTKPNGPEEVYVKNVLANSCTVEWTPPKSDGGSPVTGYAVEVCDEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FRZ2</accession>
    <name>A0A3P7FRZ2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021426">
        <property type="protein sequence ID" value="VDM35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FRZ2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22028">
        <property type="entry name" value="HMG-box_SoxA_SoxB_SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="433" mass="48749" checksum="D703B51075AEC830" modified="2019-02-13" version="1">MIPPPKQKDVSKVSEGDSKVFKSSSRESLDSGTTTSKAERVKRPMNAFMVWSRSQRRQMGLENPKMHNSEISKRLGSMWKALSEADKKPYVEEASKLRARHMEDYPDYKYRPRRKQKPNHSSQISAKQPAVANPTNRLTPLKANPLSYDSVKVSQKFTSPPVPLHLPTYDPLTDTDSMVLHYRPKVQERDISETYSFEVQTKPYFEGMSINSTSCCYSSEQHQSIPYEYSSYSESSTTPMDFFNPPDPQMQTLVVEYAGVQESPQYPINPPNPHPSTPVHPPQPAPTMFPPMALSTDFDQTVPYRDWNRSSAVDGNVTCYYEYNLEEEGESAGGDAAPVEPFEGMSPDAAVLPSMSHMASTLRLGSTDSVTVSHSTPRCLTPMSYFQSHGSECTMQQQNDLGLQNFFEDGSFCARENRFSQYGFPNSVVDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FXC6</accession>
    <name>A0A3P7FXC6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020670">
        <property type="protein sequence ID" value="VDM33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FXC6"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="1">
        <location>
            <begin position="156"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="242" mass="25927" checksum="164FA49030972898" modified="2019-02-13" version="1">MRENINASLVKQASPGEKPAKVSVNDILIKAMAIANKAVPECNSAWMGNFIRRYASTDVSVAVATPNGLITPIIFNADSKGILTISQEVRALASRARENKLKPEEFQCEMLEETDIRQVLSSALHANEGADLVVAQRHRGVPSSRLSICLGSKACGGTITISNLGMYGISSFSAIINPPQACILSVGGTEQVVVPDEEEGHKAVTKLAVTLCCDHRVVDGAVGAKWLKEFKSLIEMPARMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FZI6</accession>
    <name>A0A3P7FZI6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020844">
        <property type="protein sequence ID" value="VDM34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FZI6"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="831" mass="92324" checksum="0CEB43D6961CF36A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4L9</accession>
    <name>A0A3P7G4L9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000032">
        <property type="protein sequence ID" value="VDM16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4L9"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1270" mass="139538" checksum="BF40394160DEFFF1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6P5</accession>
    <name>A0A3P7G6P5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025006">
        <property type="protein sequence ID" value="VDM37014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G6P5"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="69" mass="7692" checksum="869C80993B11F3E9" modified="2019-02-13" version="1">MWAEDMDRRISCAIDYGRKRRFLNDGDNVVVVTGWKAGSGATNSLRIIQLGTPAETHVLGVPELKDFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GD54</accession>
    <name>A0A3P7GD54_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000918">
        <property type="protein sequence ID" value="VDM19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GD54"/>
    <dbReference type="OrthoDB" id="5988811at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="200" mass="23559" checksum="5F2D8F805CD034AF" modified="2019-02-13" version="1">MVPDMASARLALLKREGRPIFRRNPRIFPPAKSKLLRVREPRVRDPVETELLNKWWSDYRRQMAAIVDALRYCFESKGDRDSDPYRVNEKVFDEELIAINERWNAQTKLAREHYYFEDFNRKIAKLLEKREKYDAEAVKRMEALRAKTLSMEGQCKGIVTRENIDERLEEIMSSPIVQFNYAVSERGTIVHPKSSGDPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GZF2</accession>
    <name>A0A3P7GZF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008051">
        <property type="protein sequence ID" value="VDM27252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GZF2"/>
    <dbReference type="OrthoDB" id="6258937at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="165" mass="18548" checksum="AB1303F16C56ABED" modified="2019-02-13" version="1">MKQSIKKRAFISPPPERHLNRIGLVFHREDDQQLGDGKTTTAIAKVTAFQQTYNGLLPHLQDLETALRFLLPIFALAKAGVVIGGFSKSRRILRAAFNRIFALRNTPLCHNQTRDKISQATETSIVPNHVESIPFTVLTNSPIPRIDPRKTPVYINLEDVEELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HG56</accession>
    <name>A0A3P7HG56_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mon2/Sec7/BIG1-like HDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020760">
        <property type="protein sequence ID" value="VDM34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="6">
        <location>
            <begin position="369"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1697" mass="189422" checksum="263066521482262F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HN19</accession>
    <name>A0A3P7HN19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023072">
        <property type="protein sequence ID" value="VDM36132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HN19"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="194" mass="20584" checksum="831E57EEDF6E06AE" modified="2019-02-13" version="1">MATFPLFPSLSHKTPGSTGQLAKTQSRLGHPPAPGVGQSGLLAPGAFAQSGAPGGSISPHLSGSAFHLIGSSSASAAATAATLTAGGINLPMQSADSILLGRLLHEKETMLQQQLQDLTRLRFQNSEMEVRIKSLQRELDSKTSRLNALEVAQVRSILIQHLPFGTAKGSNFDLQLNCPIDHFDNNKKGSYFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHP5</accession>
    <name>A0A0R3WHP5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS75</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01000005">
        <property type="protein sequence ID" value="VDM15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHP5"/>
    <dbReference type="STRING" id="6205.A0A0R3WHP5"/>
    <dbReference type="WBParaSite" id="TTAC_0000007401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000007401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000007401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000007401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43337" checksum="26B8C5AA588F4FCC" modified="2016-01-20" version="1">MRAVGRCLRSAKRCFGAKFSTKEDLNVILCRQIRSAGPISVAEYMKTVMHHPAYGYYNNSSVLGPDGDFITSPEISQIFGEILGVWIVNEWINYTKSTPFDIVELGPGRGTLMATVIKVNDRLREMQESVISPILKTYCIKPGLSWYSSLDEIPTGCVTFYLANEFLDALPIHQFQRVGDVWKEVFVSTIGPSTSEEAGDQLVFVTSPSSTIAASTYLPLAGDLSNKKCVEVCPEAGAILQTIASRIATDGGSALISDYGHLGECEDTLRAFKDHKLHDPLKDPGQADITADVDFAFLRRSVEAAKEPVIFHGPVSQAYFLVHMGILLRLKALVEKAEVEEDKKSLIAATEMLVGSNQMGKRFKFVALTPARSRKEKEHIPGGFYPTWDTTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIB6</accession>
    <name>A0A0R3WIB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS334</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000025">
        <property type="protein sequence ID" value="VDM16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WIB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000033301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000033301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000033301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15671">
        <property type="entry name" value="ePHD_JADE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF160">
        <property type="entry name" value="PHD FINGER PROTEIN RHINOCEROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="200"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000033301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75109" checksum="A4536E6A0C3A610F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIW3</accession>
    <name>A0A0R3WIW3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS570</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01000057">
        <property type="protein sequence ID" value="VDM16665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIW3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000056901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000056901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000056901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6238968at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GH84" evidence="10">
        <location>
            <begin position="37"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="905"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000056901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119695" checksum="794DFAAC2B224AF0" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ2</accession>
    <name>A0A0R3WJJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">snRNA-activating protein complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS842</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000111">
        <property type="protein sequence ID" value="VDM17066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJJ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WJJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000084101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="327"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="115001" checksum="4EF0E142CA255FB6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJP4</accession>
    <name>A0A0R3WJP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS906</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000127">
        <property type="protein sequence ID" value="VDM17161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJP4"/>
    <dbReference type="STRING" id="6205.A0A0R3WJP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000090501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000090501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000090501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000090501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31906" checksum="94BB745443E4D125" modified="2016-01-20" version="1">MGIPDSQIILMIGDSYACNPRNPRPGTVYQSAYNPIDLYGDDIEVDYRGYEVTVENFIRVVTGRLPPSAPASKKLNTDQYSNILIYMTGHGGNGFLKFQDDNELSSVELADVVNQMWLRRRYNEMLIIIDSCQAESMGSQVYSPNVVTIGSSKVGEDSFAHHFDTTIGVFVADRYSYYALQFLERLTHESQHNLVEFLNLCTFNMCKSTVKFRTDLLVKKPHNVLVTDFFSNTHHVESGSYLLPAGDVNLTDGVCAEQLGASNNLTNDHTWVYVQPFPVELTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKF4</accession>
    <name>A0A0R3WKF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1193</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000209">
        <property type="protein sequence ID" value="VDM17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKF4"/>
    <dbReference type="STRING" id="6205.A0A0R3WKF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000119201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000119201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000119201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1244179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="160"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="464"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000119201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="744" mass="84147" checksum="7804F2FD947DA56C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKZ7</accession>
    <name>A0A0R3WKZ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000301">
        <property type="protein sequence ID" value="VDM17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKZ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WKZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000142401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000142401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000142401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000142401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26823" checksum="8A43BB57D9C8025C" modified="2016-01-20" version="1">MPHEDFGPDDCFNDIKLKFRPARWPKIDLYPEAKEDLLRSFNLFDKSGLGVASIDSVKVGAFNQEALNMVNTDKLMFPDETIVFGDYLKLLSEWIFNVDQDLDVEKAFSLFDIDGKGYIDFADLRRVRDRLGYSQEIDDSEIIDMLIGSQVNDAAEELKEIYEARQDKTRLRKGQGYATSLVGEVGGGGTESGPMLAPPSIGMHRRTSSEDAFDPAGLTVDFDKFKRVLQLEAAPPEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLB8</accession>
    <name>A0A0R3WLB8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1543</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000368">
        <property type="protein sequence ID" value="VDM18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLB8"/>
    <dbReference type="STRING" id="6205.A0A0R3WLB8"/>
    <dbReference type="WBParaSite" id="TTAC_0000155601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000155601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000155601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="43"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000155601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51431" checksum="74FF6E9526B56615" modified="2016-01-20" version="1">MNRCRTMSGSQPNLSFQPPWPEPQPKRSNSLSELGTGRGFTDPILLEGVGSGTYSVVYKCKLENNGPILAAKVMKMNPSEGAPGTAIREASILRLLKHDNIVTLHEVIYKPGQLTLILEYIEDNLSTYMMKCDLPRDSDTVQRFSIHLFQGLTYIHRMKIIHRDLKPDNLLITNSGVLKITDFGKFSWSQGDFKRMARQKFAPMCDLGKRVVTLWYKAPEILLEGCKYDFGIDVWSAGCIVYEMMNGEVLFEGSNPLTQICRIFQVLGMPPLSYWPDLRCNQTFQKIQEILEKCYPTVGPTLEIYDIKTHLKNSFTNLSNRHWREHADAFDLLEACLQPYEPKRITAKEALDMDFLVKRVIPSQNFQAHGLVSWKRCSQTSTLSNSKAIFSITEVNNDPSARRGLDYVPQHSKSSLRFIGEIACGPIANLEHGQAVFIHRELLLFPLVHQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLS9</accession>
    <name>A0A0R3WLS9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin NUP42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleoporin-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1704</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000457">
        <property type="protein sequence ID" value="VDM18419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLS9"/>
    <dbReference type="STRING" id="6205.A0A0R3WLS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000171701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000171701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000171701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000171701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21638" checksum="F8C8E7903A653A84" modified="2016-01-20" version="1">MYSAICHHYLAGYCRNGDDCIFIHADPAYKPRSPYTYSAPHYERSFLRNFGSPRVCRFYQMGYCAYGAGCEFLHPRDKALNTSQQPPRDPNIQRQVPTSKSDRFHYRKTVDAEPTPTTFSFKKTLESLLLRDTASAAFAKREDFGYKREEVFSAKENLSDEDLKIYSETGESGFSSIPLLPPPEDLCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM50</accession>
    <name>A0A0R3WM50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1825</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000537">
        <property type="protein sequence ID" value="VDM18565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM50"/>
    <dbReference type="STRING" id="6205.A0A0R3WM50"/>
    <dbReference type="WBParaSite" id="TTAC_0000183801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000183801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000183801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17382">
        <property type="entry name" value="MFS_SLC17A6_7_8_VGluT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001045">
        <property type="entry name" value="Solute carrier family 17 (sodium phosphate), member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000264">
        <property type="entry name" value="vesicular glutamate transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF456">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000183801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54573" checksum="5333F21F5C51C8ED" modified="2016-01-20" version="1">MDYQRWYLNVLSNGVSLILQKPNFYWTPGERGFVESAFFYGYMITQIPGGAIATIFPANRLFGIAVGGSALCNLIVPIACRGSYGVVAFIRVLQGLVEGVSYPACHGIWRYWAPPIERSRLATIAFCGSYAGAVMGLFMSGILAQYMGWQSPFYLYAILGLMWFGMFWKTTYEKPSTHPKISAEERDYIEESIGEVDLPPSLKTIPWKSIFTSMPVYAIIVANIARSWSFFLLIMKCPKYLKQVFECTTAESGVLSSVPHLIMAIIVPISGQLADRLRKRTLTTTAVRKIFNCGGFGMEAFFLLIVAFANSYTTAMVSLILAVSFSGFAISGYNVNHLDIAPRYASILMGLSNGIGTISGIICPVIVEYITTQGWMWVFIMASSIHFFGVTFYAIFASGEKQHWAEAAEDAQMMDWRSPTDVPENIVRSGYDYGTEEGGDIEASLRQPLKENASRNNDVHNSNPSRTFMTQTFRASNRSEAEDDAYHQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM51</accession>
    <name>A0A0R3WM51_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000538">
        <property type="protein sequence ID" value="VDM18566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM51"/>
    <dbReference type="WBParaSite" id="TTAC_0000183901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000183901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000183901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000183901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9513" checksum="E4116668BDE8A173" modified="2016-01-20" version="1">MAETETCHLLEQHIEHIVQRQDEGLDSTKTRSLGLAADVKALGGPRRGAEGTVGGYNHLLVDQLSSDTIHFSDDGNMMHPQKFQAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMB0</accession>
    <name>A0A0R3WMB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1885</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000582">
        <property type="protein sequence ID" value="VDM18625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMB0"/>
    <dbReference type="STRING" id="6205.A0A0R3WMB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000189801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000189801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000189801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000189801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17670" checksum="549823429003F2F6" modified="2016-01-20" version="1">MKCHFFKIQMKQVEEYMSYRKLPRELRNKIVDYYEHRYNGKFFNEVEILQEVSECLRDQIINYNCRSLVAAVPFFKDEDENFVVDVLNRLKFEVFRPDDVIIKHGTFGTKMYFIREGTVDIVLPDGSVVNTLTDGAYFGGQVDYYFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMI7</accession>
    <name>A0A0R3WMI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VGCC_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1962</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000642">
        <property type="protein sequence ID" value="VDM18702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMI7"/>
    <dbReference type="STRING" id="6205.A0A0R3WMI7"/>
    <dbReference type="WBParaSite" id="TTAC_0000197501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000197501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000197501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-2/delta subunit conserved region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000197501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19511" checksum="A283DF590C123457" modified="2016-01-20" version="1">MESLLENSVYSRVRYYDYQAVCDSAHLGEKNSTSPATHLLPDLVRGFCQLFSPRSWLLALQKASVVIIKLTNVFMVFLQMLVNAFALDQGVDYVNCVKSTYRYYATDGANFKKDPFSSVEVVGNFTCSPLCTRQWSSSSIPETNLKLIKTDPICACFKKDYDWQLTPSIGTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNC5</accession>
    <name>A0A0R3WNC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein COX15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2250</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000893">
        <property type="protein sequence ID" value="VDM19370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNC5"/>
    <dbReference type="STRING" id="6205.A0A0R3WNC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000226301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000226301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000226301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000226301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45242" checksum="423A96BAE481C83F" modified="2016-01-20" version="1">MPLLFSQSVFRSLRASNLLRGINVLNKPSWRTPRRTLSTHIDSIVKGLPNGARKSVGYWLLGMAGLTFGAIGIGGVTRLTESGLSMVDWHPFKEVPPRTEESWNKEFEKYKQFPEYEHVVKDRGEMTLSRFKFIWYMEWCHRQWGRLIGVAFALPATLFWYRGYFNKGMKIRVVCYGVLIGFQGLLGWYMVRSAGMDPGEEFVGVPRVSHYRLAAHLSTAAILYSLFLWSGFSHMCTHPTGLDCLMDILSHPRMFGGWYSFARTHVGAFVAGLDAGLTYNSWPKMADRWVPDDLLVARYGSTLRNLVENPTAVQFMHRNLAYLTVALVTGAWVMTLRVPGGRLRNAAHFMLAATIGQSAIGIITLLQYVPVWLGATHQAGSLVLLSTILWYTHCLRAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNE6</accession>
    <name>A0A0R3WNE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fragile X mental retardation syndrome-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2270</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000915">
        <property type="protein sequence ID" value="VDM19449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNE6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNE6"/>
    <dbReference type="WBParaSite" id="TTAC_0000228401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000228401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000228401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424249at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20402">
        <property type="entry name" value="Tudor_Agenet_FMRP-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18336">
        <property type="entry name" value="Tudor_FRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Agenet-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Synaptic functional regulator FMRP KH0" evidence="3">
        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM19449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000228401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="594" mass="64280" checksum="17AE53DBC1A826F3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP40</accession>
    <name>A0A0R3WP40_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">APG6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2515</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001162">
        <property type="protein sequence ID" value="VDM20300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP40"/>
    <dbReference type="STRING" id="6205.A0A0R3WP40"/>
    <dbReference type="WBParaSite" id="TTAC_0000252801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000252801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000252801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="242"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="169"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000252801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47827" checksum="E51FD582384285E6" modified="2016-01-20" version="1">MPHCYEYNSGAASPTYSPTSSLDHRLQVNAYLFDIINGRTEINHPMCQECAEILIRTQQQLLDFQNEEIACLESLLEELKANKTEKTGSNTNVENSAEQMFLTSGQSGQASSLSVRGSLDEDLPDQLDTSVENDEDGLFRELHATEDSPVETNESNVTTTDPHYTEEGLRSLHQEFVRLQRESRLLDQQIATNEAALLVRQTELDRITNEYNEQRLTVMEAEESLNVLDARLNDARYQYERLRRTNVLNAAFPIWYDGHIGVINGLHLGRLASKPITWPEINGALGQCAMLVTCLAKKLSYTFKSYVIIPMGSQSKIVALPNGTPLPLYNSPGSLRLFSSTSFDNALVMLLDCVGQLQTRVERPPDFCLPFKILDGGCIQDRSGSVFSIKCSTTTDENWTKALKMLLMDLKYLIAATVGKSDSPISKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN4</accession>
    <name>A0A0R3WPN4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2708</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001412">
        <property type="protein sequence ID" value="VDM20954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000272401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12087" checksum="00FAC740D631B17C" modified="2016-01-20" version="1">MADSELPPSDSQNIFLFTLIVRSMLYGFGDVENPLPETVAMVEEIAIQYILDMTRRAMEIGRVGKITVEDIAYLVRSDPRKFSRAKELLLLSEELNKAKKAFDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ09</accession>
    <name>A0A0R3WQ09_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AN1-type zinc finger protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2834</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001566">
        <property type="protein sequence ID" value="VDM21285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ09"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ09"/>
    <dbReference type="WBParaSite" id="TTAC_0000284901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000284901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000284901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000284901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20519" checksum="D37938C1D591312D" modified="2016-01-20" version="1">MEENDQTQAGPHLCRKGCGFYGSPNFDGFCSKCHRDMQEANKHGNSVPGDFGEGILKSANTVVFNPYAASNSTDSVMNQGTEAAEKCSVSPPFKDASDDSNKASLPVKCSTVNTGETETTSGANESAAKTRPRCMVCNKRVGFTCRCGGLYCTVHRYSDSHDCSFDYRESGQADIRKANPQVICSKINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQE4</accession>
    <name>A0A0R3WQE4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GYF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2969</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001749">
        <property type="protein sequence ID" value="VDM21642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQE4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQE4"/>
    <dbReference type="WBParaSite" id="TTAC_0000298401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000298401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000298401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000298401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="463" mass="50560" checksum="11D3EE7B7EE6EF98" modified="2016-01-20" version="1">TKADVRDASISYADEAFAENPDSSFLSWKKCSELQSRDRINPDIHVTGPQLMGLRSEDFAYRMGVVPSFYVQSNAPVSSNNIENPACPMFPGEISTPSWCSASWADSNLGPGGGRKGVEWAKSLQDPTGEVDSLFQRSEFERSWRNRTSSDGGGMSPHKNVPVLRSGQSASETSTSNSQQNRNLHRRRGRTASVSSTSSPDSPTNIAVGDEGRSINLPPGQGINTADFGAATCLPDAVARMSFVADPSTVQRPIPPSESSVLGQALSVVDRSCLLAHQTQSNFWPPSSTSQEAVPCSGVDSMVFNQKVDGYHRPTTSNQYTQHDALGAFRNKVPGYAKIPCVADLARSNEQMNHNSSVTKTKSRPVQNAFGYEGDGLDPGQQGGGTGSGALNDDQLWYYEDPQGNIQGEFSSAQMLNWLLAGRYFTSNLRIRRKCDDTFSTLLDFYKRKIVKFRPLHRSYNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQI7</accession>
    <name>A0A0R3WQI7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3012</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001801">
        <property type="protein sequence ID" value="VDM21743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQI7"/>
    <dbReference type="STRING" id="6205.A0A0R3WQI7"/>
    <dbReference type="WBParaSite" id="TTAC_0000302701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000302701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000302701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161999at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17057">
        <property type="entry name" value="Ubl_TMUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040352">
        <property type="entry name" value="TMUB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557">
        <property type="entry name" value="PROTEIN C7ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557:SF5">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000302701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41646" checksum="154B87B0370AEBCF" modified="2016-01-20" version="1">MILPEFIEGVGNEVLICALSLGGILLCVGFRLYSHGFRVLPSPSNAHSQSMNSNSHNVESTEHADSDEVAVAYHTGVLDTDYMESLRDVNHHHETDSLEVGESSQGKTRADNERELREARAQGNIVLRLQYLNDRVRYVHAPPEMPVLLFKRKFFADELERQHKSVRLIFQGRELKPSAAASRDSPSRRRLCDYGVSDNATIHCLISDAPPNSASSSSSTSADRVASPAGSVLRPNFSAPEDLDFGSHAMMPLFAFLLTSVWIFRIAHAEYFSLVSTVALVCLSALFAGAVFSSATVHRRHTAERSSVAAEERKQLPIWSHREELVEIVKKYPNCVIVSSTGSGKTTQLPQFLFEAGLAKSNMIAITQVSCVFCTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQY5</accession>
    <name>A0A0R3WQY5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat-containing protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001999">
        <property type="protein sequence ID" value="VDM22075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQY5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQY5"/>
    <dbReference type="WBParaSite" id="TTAC_0000317501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000317501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000317501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000317501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="31909" checksum="96B4973656704989" modified="2016-01-20" version="1">MDAYSGLLLDDAAFSRVPEQNKPVFIYDWLRSLDRRLSQSTKTEVRNVQQALIDQLMVQVTQGVGPPSRKLLGRCLAKIFTAGDSISLYAVLNSCNDVLKVRDDSPSAINKRLTALACLGVMYRSLGRLCGRSFEETVGILIRMIKQVESQTRSEILTSLMNIVTGLGAAETSCFRDIFKVARSFINDRVLAVRLAAVQCLTSLTRYHSHFFTSDLDAVTSMCIKGLDGSNHAVRMEIAKLLGFVLAKTQLDSGILGTVGSMNSVTGNTSTGGISSIAYNLMNDLAFGLFSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR28</accession>
    <name>A0A0R3WR28_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase_M28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3203</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002064">
        <property type="protein sequence ID" value="VDM22146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR28"/>
    <dbReference type="STRING" id="6205.A0A0R3WR28"/>
    <dbReference type="WBParaSite" id="TTAC_0000321801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000321801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000321801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M28" evidence="2">
        <location>
            <begin position="275"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000321801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54023" checksum="9B82481DC63E6CA6" modified="2016-01-20" version="1">MDWRRWGWPIVRMVNFTVRLPRGPPDESQWNQVVILNRSTHEERRRAQNYVIFNCTNRSYHGNSTCLSEEKFTAPAYCGFAGNGRATGRPVFVNYARAEDLAFFTSIQGLCLQDIIVVARHGYNSYGSKVKQVVKRCSSLGSSTLPGGMIIYRDPTDSTPDIKVYPEGIGLPTDGVAYRVSSMAKLSGDSETPGFPAIDGVYRIEKAEDQAVTPFPVQTVNYNDAEVIINGIGGKPTPKAWEPCTPKFVGPEGDSLIRLEVRNRIDETPSKIVDVIGVMPGRGTEAGKYVILGNHRDAWVQGASDPHSGTVVLQGIAYLLGMAYREGWRPRRSIVIASWDAEEVGLIGSTEFTELFRNELMDKAVVYFNQDSPVKGNAVFSLRADQFLEKALLDSAKSVHGPCNASISFLKEWDKRTKRKKYKKPETVPVAGSTDHVPFQYQLGIPSAYPQFTPKPPLYEAPSYHTAYDSVDMAVNFTDPPCSTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB8</accession>
    <name>A0A0R3WRB8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3294</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002197">
        <property type="protein sequence ID" value="VDM22333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB8"/>
    <dbReference type="STRING" id="6205.A0A0R3WRB8"/>
    <dbReference type="WBParaSite" id="TTAC_0000330801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10227" checksum="A3F9EA4B3BD47542" modified="2016-01-20" version="1">MAEAKAPVDLYIHLGSHLSPPSPAGVATSGTSETEDLHQGEKKSKKKRRFKLPSLARKTRTKEKKPQQESQAQSSNVGASEGTAGNEIDGESRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRE5</accession>
    <name>A0A0R3WRE5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ANF_receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3319</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002245">
        <property type="protein sequence ID" value="VDM22391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRE5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRE5"/>
    <dbReference type="WBParaSite" id="TTAC_0000333501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000333501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000333501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="74"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000333501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27297" checksum="2D2B40F151D22D80" modified="2016-01-20" version="1">MDFSRWIWIVLFVAVSELQLAPYGALYQKLKVRIPGDIMIGALFPIHEQPTVNTAFSRQCGSVREQYGIHRIESFIRTIQTINENEDILPGIRLGVDARDSCWYAPIALEQCMDFIRTAFVYREYEDCLRMTNGSTERCLPPGVSPSSIEIPIAALIGPGSSEMTKQVHQVLQLFSIPQIGYSATAAELSNIAEYQYFLRVVPSDALQVEVIASLLKRYRWTYVALVNSNGEVLLTPFLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRG2</accession>
    <name>A0A0R3WRG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Abdominal-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3337</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002267">
        <property type="protein sequence ID" value="VDM22415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRG2"/>
    <dbReference type="WBParaSite" id="TTAC_0000335201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000335201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000335201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000335201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="14737" checksum="FE063773F1BE4B2F" modified="2016-01-20" version="1">MPWPTDPRFASYFLPGYPAALAAVMAAMRSSASPVCGFSATGGAAAATGCHNDYSPGAPGGGFLSGLASSSTSPTASAPPPSNSTFYTPPWEPQGAMATNASAFGSPTATGGSVDGYVGAAGGGGGGGGGGGGSACQRDSSIDDRGQAAFVSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSA0</accession>
    <name>A0A0R3WSA0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3624</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002757">
        <property type="protein sequence ID" value="VDM23007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000364001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000364001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000364001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000364001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="7189" checksum="8C35F45F3EE757CA" modified="2016-01-20" version="1">MILFWEREEEGEEEGEEEKKKKVEEEEEEKKGRVDMHPPILEIKWVDNDEPRLVRAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSS1</accession>
    <name>A0A0R3WSS1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SMK-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3796</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003075">
        <property type="protein sequence ID" value="VDM23402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSS1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSS1"/>
    <dbReference type="WBParaSite" id="TTAC_0000381101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000381101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000381101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000051">
        <property type="entry name" value="Serine/threonine-protein phosphatase 4 regulatory subunit 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="5">
        <location>
            <begin position="152"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM23402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000381101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="661" mass="76157" checksum="491C5F9CF568879F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTD7</accession>
    <name>A0A0R3WTD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4147 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003475">
        <property type="protein sequence ID" value="VDM23981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTD7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTD7"/>
    <dbReference type="WBParaSite" id="TTAC_0000402701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000402701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000402701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133032" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000402701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9938" checksum="FCA3DDA903246E42" modified="2016-01-20" version="1">MIDCILIIKATIFPVLLQLITDDVNVLLNNDNIVIESATSEEAAELISNIAYVKPRSTSTQLTFGPPVSNARAIELATVFSLENLMIGEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTW3</accession>
    <name>A0A0R3WTW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Breast cancer type 2 susceptibility protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003865">
        <property type="protein sequence ID" value="VDM24384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTW3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000420301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000420301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000420301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000420301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="542" mass="60005" checksum="2A096D3BC037569A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU28</accession>
    <name>A0A0R3WU28_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4253</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004011">
        <property type="protein sequence ID" value="VDM24528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU28"/>
    <dbReference type="STRING" id="6205.A0A0R3WU28"/>
    <dbReference type="WBParaSite" id="TTAC_0000426801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000426801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000426801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000426801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14989" checksum="9BD91BA6CE2BA464" modified="2016-01-20" version="1">MSEAKAEVVPAKRVRQKQPGRLYVKAVFTGYRRGLRNQHERTALLKIDGVNTAKETEFYMGKRCAYVYRAQKKKRLPRRHNPTRIRVIWGKVMKPHGRSGAVRARFKRNLPAKAMGKRIRVMLYPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU69</accession>
    <name>A0A0R3WU69_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-and gamma-adaptin-binding protein p34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4293</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004093">
        <property type="protein sequence ID" value="VDM24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU69"/>
    <dbReference type="STRING" id="6205.A0A0R3WU69"/>
    <dbReference type="WBParaSite" id="TTAC_0000430901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000430901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000430901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000430901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27539" checksum="819B79C23FE4792E" modified="2016-01-20" version="1">MLPQVHILNAHADDIANLVYDELTKTSSVRDCMNIDCKYYTASVQLKLIPYSYSKTDVKGTEALMICFDSGNPESWSVACDWLKLGEEEDIAVHLLICDSLSSENFRTEVFKEATKYHFEIVQLSPHCDEIEEDEEYGVARITAALVAHQWPNLVLKSSQRDICECVPAGHSQRKPKVATPEKKANQKDAFNGDEDETKIDSEMFNELFPKLVEMRTRCTSMDLEGRRKMAERVRVLKLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUD3</accession>
    <name>A0A0R3WUD3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4358</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004220">
        <property type="protein sequence ID" value="VDM24745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUD3"/>
    <dbReference type="STRING" id="6205.A0A0R3WUD3"/>
    <dbReference type="WBParaSite" id="TTAC_0000437301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000437301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000437301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000437301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36462" checksum="C7D02BE13FF4C21D" modified="2016-01-20" version="1">MFSDSLLKCWLATLDGATETASDHCVPLWFHLQYVFLQPSSAPIATDLQKDQCKVLLEFMEHGPIGEFHARWRLLAALHSALAIWPGLPDTQRVAARKLVGNVIWFYGQFIPHVDEFLFDQQKPIREAIKNFISIMKWGDYISFWTMKENVDRCKRTIHKHVRTWEGILRQSVKPIFEASVKTSIDVPISDAALSALGTVQMANGQGCAIFQLSTELQKWLSEMGGERELPINIRRLPVLIKRFKSHVSQIARKAPCLSWVQQIRACLGDWMLRVRELSRSTQQLDLEPPSQSALTLVLKEKQGVSQPSKGKFAKIDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUI8</accession>
    <name>A0A0R3WUI8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS4414</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004357">
        <property type="protein sequence ID" value="VDM24883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUI8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUI8"/>
    <dbReference type="WBParaSite" id="TTAC_0000442801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000442801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000442801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="12">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="11">
        <location>
            <begin position="140"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM24883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000442801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34848" checksum="23047BCD271937E4" modified="2016-01-20" version="1">MLGVEETIKLIEILSFLLGGLDFFFSLRSEAVAFVDYVSKLVPCRVQTSQQLKSHDVHSNTYNYKFTFCLDVVPICKNDVVCLSKQFCNRLGLGNQILLVSRITDKIRLLDPVSCVAKDIDVQTYYANPFASISSPRNVSEFFVMDVESDAHGKIQSSPAEPEVEQVNMKPAGVWVVPSAYLGVEGEDGEQIYVRTHLGHVVKIGDSVIGLDLRNANINNVEFENIPEEKRPQVVLIQRLCSSSNRRRRRHRDCVSLDGESVMETETAPTTEAGLVSDTEMEGNEDNAGDSDDTISEYSDSEYMDAEEGTFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV20</accession>
    <name>A0A0R3WV20_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MyTH4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4594</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004848">
        <property type="protein sequence ID" value="VDM25248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV20"/>
    <dbReference type="STRING" id="6205.A0A0R3WV20"/>
    <dbReference type="WBParaSite" id="TTAC_0000461001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34380" checksum="39198E98D9E52AD3" modified="2016-01-20" version="1">MNGSTLGRIEESSTSSALQHSISMCPRVVISSTNGSRRDIPLIDYRDEVSGNVYSSYTPTVRICHECRPILSEFHKVRYIVGTGVDHPQMRDEIYCQILKQITRNPCVYSRSRARFDTALRAYLKSNASDYAKTCLKRLNRIHQTGPRSMPPSYMELRAEQEKKSLGVNVLCANSNRVRVKVDPTITVQEFSSIAFSAASIKDTFGFEIFIDIIDKFEALSTGPRHFFDSISLCEEYTRRKGLNEFDMPWSFSIRKTIFAPWHDVTFDPVATSLISFQVIQQCFKESHDCLEVSKVRGIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVC3</accession>
    <name>A0A0R3WVC3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005122">
        <property type="protein sequence ID" value="VDM25473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVC3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVC3"/>
    <dbReference type="WBParaSite" id="TTAC_0000471301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000471301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000471301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000471301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22702" checksum="755B90CBB3B9E254" modified="2016-01-20" version="1">MFDILLVDANSQSAKTLTSGTAAGGSPDQFPDIKQEHVTSVADSQFTDGNTDVVSRRPFGLATFSPPSQIFDASLALRRAVNHLDLANYEPSTIAPLPSVRSKQSKFKNNAQKVHSSRQAHKRTCRHYQPHPKEVDVPKVKPKSIVATDMLSEATGADLTFPSISTVALATDVPSSAPLAKSMMPPPPPPSITRKSLMFTRLLLPLLCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVR1</accession>
    <name>A0A0R3WVR1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PINc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005453">
        <property type="protein sequence ID" value="VDM25742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVR1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVR1"/>
    <dbReference type="WBParaSite" id="TTAC_0000485101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000485101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000485101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012272at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000485101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15699" checksum="8035DE18BC80F64C" modified="2016-01-20" version="1">MPKVHPDSPIRFHTFSTPLFHIPKSPPIIAIDTTTLVDLLPDPQKDILIQHVAPAVGALPEVVPLSLGLLFSAVAHSGWRLDTSRLLDAAAAVGNGRDKVLPSTLFERDFTLSFWLQREPKQDDDHETILCSQEDTGEGRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVR9</accession>
    <name>A0A0R3WVR9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4844</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005467">
        <property type="protein sequence ID" value="VDM25753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVR9"/>
    <dbReference type="STRING" id="6205.A0A0R3WVR9"/>
    <dbReference type="WBParaSite" id="TTAC_0000485901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000485901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000485901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000485901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="46" mass="5093" checksum="45F32E05365D65DD" modified="2016-01-20" version="1">MKNLDTSQAVEIVECMYSVNFATGNTIIREGEMGSVVYVMEGECRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVX0</accession>
    <name>A0A0R3WVX0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Abhydrolase_3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4895</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005615">
        <property type="protein sequence ID" value="VDM25842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVX0"/>
    <dbReference type="STRING" id="6205.A0A0R3WVX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000491001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000491001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000491001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000491001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15303" checksum="42DBE435CCEA7709" modified="2016-01-20" version="1">MVPLVILRIDVLVYVRPWAEKLECPIISLNYSLAPESPYPRALDECFHAVCWVMANRERLGARPDARVVVCGDSAGGNLSLGVCLRAAALGLRSDVARPAGALIAYAPAILAYVPSPSRMLSICDPLLPIGVISRCIMGMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVZ8</accession>
    <name>A0A0R3WVZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005672">
        <property type="protein sequence ID" value="VDM25881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000493801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000493801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000493801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284605at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000493801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="16925" checksum="FB07DC3E47E548E1" modified="2016-01-20" version="1">MSDGVQRAGRGTVAPVLSLSAAGIGGDSIDGVSVAVGGGGGDNLTAGVGSGGPRFVPLVSLPAGYVNQSTITAAAVAAAAAAASAKPTNGAPFGQSLVSKQQQQQTQSIQQRSTRQKAADQQQQQHHVDPNHTDANCDYIVRPGEVWMSRYYMDSLIGKGSFGQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWM6</accession>
    <name>A0A0R3WWM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006408">
        <property type="protein sequence ID" value="VDM26360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWM6"/>
    <dbReference type="WBParaSite" id="TTAC_0000516601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000516601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000516601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000516601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13588" checksum="18AAECADD3DFA37C" modified="2016-01-20" version="1">MHRFDAVLRIHACVADACALWRYRLPRNNFTVYLIVYATAWAWVPGISLSAPSISNERVRARSGGDVDTGLWTNRNARTSMPRITECPIRWQKRELGLRLATPVKRGREERGAFGTNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWP4</accession>
    <name>A0A0R3WWP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2052 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5169</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006470">
        <property type="protein sequence ID" value="VDM26391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWP4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000518401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000518401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000518401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269347at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000518401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46834" checksum="F00A8243AF783E82" modified="2016-01-20" version="1">SSAKEVQSRRTIADEEAQTGLKKQFPPENTITAATEQDYEAPLREYSKFSASVSQLFDSTFLNNIVAAVENEPPLSREEHLQQLRIRAGLVLRDEPSLHDYYTQSYQQQQKKTTQDRVNFTGSLPALNTQSIPKPSGVFGSFMSRAQNAASGLMKQVNVVAEAAKQAVSEAHTIISAEEKQLHQRQQSQKPQLQRQHSRKIPVGSDRLSQQETNLPELTPPTPDDAKKSSDEDVQGILMPSEFVNEEERKAARRAWGQSSSVEQDDEDFGEDNVNVDDRDEFFGDEGDSNQWIKSETQKGRLRSRREDLMMGEEEIDDEAWLRSRDKDERAAIRARDGMLMAAVTGIHDPMITGQDYCGDEDEDEDDEGHVEDANHKTARRNGRQGWNHDGDEDEIRTHMHHGKTFNSFDVISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXM8</accession>
    <name>A0A0R3WXM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007765">
        <property type="protein sequence ID" value="VDM27109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000551801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000551801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000551801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000551801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6672" checksum="0535F26A5FD38E38" modified="2016-01-20" version="1">MTRQIWCPTQPTLSNARSVTRRIPRRWDVIRVHTIISIIVATRASITDTMRVETPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXW3</accession>
    <name>A0A0R3WXW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008125">
        <property type="protein sequence ID" value="VDM27284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000560301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000560301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000560301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000560301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9041" checksum="EF9426E7CA965EF3" modified="2016-01-20" version="1">MRGRWATGGGGGGGGDDGHLSTDAPTRESDRVVWEGKLKTTTESVAKMWHWEMVDAWNKYLERKRNATTTTTVTGTTSLAPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYV0</accession>
    <name>A0A0R3WYV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF4244 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5925</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01009756">
        <property type="protein sequence ID" value="VDM27984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYV0"/>
    <dbReference type="STRING" id="6205.A0A0R3WYV0"/>
    <dbReference type="WBParaSite" id="TTAC_0000594001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000594001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000594001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Set2 Rpb1 interacting" evidence="4">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM27984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000594001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9922" checksum="98AF85BE0563156D" modified="2016-01-20" version="1">MEVEQRRTTQQSEETRLKTSFIANVVVRSLSRYYSLGAFKDKAIFKEVARELTRRLVKSGISDDDGKCSLLVVFSLMVTGIGTSFIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYV5</accession>
    <name>A0A0R3WYV5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphagen kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009783">
        <property type="protein sequence ID" value="VDM27994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYV5"/>
    <dbReference type="STRING" id="6205.A0A0R3WYV5"/>
    <dbReference type="WBParaSite" id="TTAC_0000594501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000594501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000594501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000594501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15645" checksum="A94C9494EF0D3E64" modified="2016-01-20" version="1">MGTAISFVNSSEESQLLEVANLLLQKAAFNPQSDQPSKSAVDLIFRPYQFRLSEVDGFRYRALDIVGKITRKRIREARLKEIKLELMNSERLKSYFEDHSADMDALRHDKPLSSLQQTHLKDVPEYMDNSPSNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZA2</accession>
    <name>A0A0R3WZA2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS6093</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WZA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000610801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000610801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000610801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X018</accession>
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        <recommendedName>
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        <name evidence="10" type="ORF">TTAC_LOCUS6424</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
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        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000643901-mRNA-1"/>
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    </evidence>
    <sequence length="577" mass="64333" checksum="F1C7E1939EC46096" modified="2016-01-20" version="1"> </sequence>
</entry>
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    <accession>A0A0R3X1G3</accession>
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        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TTAC_LOCUS7025</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000704001"/>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
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        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110204" checksum="504D33D3AA6AE432" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2D3</accession>
    <name>A0A0R3X2D3_HYDTA</name>
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        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7429</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDM31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:regulation of gene expression"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="106"/>
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        </location>
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        <location>
            <begin position="82"/>
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    </feature>
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        <location>
            <begin position="82"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000744401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15726" checksum="C20A5A9B09099B36" modified="2016-01-20" version="1">MGINSTCANNETSLPPDVRMASSVVDANPKLASCLSSNTNCASPSNHISLSNNGSIGMEFVGGPLDDLKNGTANVTVVEAEGQEADETEVEEGEGDEETVFPHEPGKIFIGGLNPSTTIETLKFYFRKYGEIKNSLIMRDIVTKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2F5</accession>
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        <submittedName>
            <fullName evidence="15">SWI/SNF complex subunit SMARCC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7453</name>
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    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="6">Belongs to the SMARCC family.</text>
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        <property type="protein sequence ID" value="VDM31832.1"/>
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        <property type="protein sequence ID" value="TTAC_0000746801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000746801"/>
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    <dbReference type="OrthoDB" id="118550at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SANT_dom"/>
    </dbReference>
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        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
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        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
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        <property type="entry name" value="SWIRM"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="480"/>
            <end position="577"/>
        </location>
    </feature>
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        <location>
            <begin position="723"/>
            <end position="773"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="992"/>
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        <location>
            <begin position="1222"/>
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        </location>
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        <location>
            <begin position="1028"/>
            <end position="1069"/>
        </location>
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        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="948"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1232"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1267"/>
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        </location>
    </feature>
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        <location>
            <begin position="1279"/>
            <end position="1310"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM31832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000746801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1310" mass="142878" checksum="58090E4DAE680154" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3A8</accession>
    <name>A0A0R3X3A8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7806</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020406">
        <property type="protein sequence ID" value="VDM32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3A8"/>
    <dbReference type="WBParaSite" id="TTAC_0000782101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000782101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000782101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6225981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000782101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15650" checksum="8337BF63C2185A88" modified="2016-01-20" version="1">MDGLRITCLLNPSKTNHFRINDLEAILILNGFYPSREDIEQAREKYGDFVSKKQVEDELCRQKNKPPIQMKILFEEIKDMLKVKRGYFSREDLITLFAEEKRPLKEQDVDTLLKDICDNGFLERLTRPVNASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3B1</accession>
    <name>A0A0R3X3B1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7810</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020407">
        <property type="protein sequence ID" value="VDM32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3B1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3B1"/>
    <dbReference type="WBParaSite" id="TTAC_0000782501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000782501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000782501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="3"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000782501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="320" mass="34823" checksum="58F14291EA56113D" modified="2016-01-20" version="1">MLVGLNVAISDLGSEIFSTIYGVKATFTTRRCVLLVIIALITPFCFLQRIDFLSATSLVAVIIYIIFLSNLLIVYLLPRIFSVYFSLKYFRLWRPEGLVRCAPIIASSLCCQVQVSTIYSSLNNPPLSTMRKVLICALSFIFICYSGAGLMGYMAFYHGLNESLPGDMLASYPEDHRAVHIRLGFLYTVAASLPLLLFPLRTALHSLLFEEAVVEEGPLYVDAPLTIPNLRFHWLTGAVIFLSVVASQATDKVEVILTNTGGFAGGASCYLLPAVIGARAVGGSGGGRGNRSTKLIICFLSFLGALIFSSPFLTFLGVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3D0</accession>
    <name>A0A0R3X3D0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7833</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptopodin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020410">
        <property type="protein sequence ID" value="VDM32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3D0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3D0"/>
    <dbReference type="WBParaSite" id="TTAC_0000784801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000784801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000784801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF0">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000784801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="658" mass="73826" checksum="497EEF94A584303D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3L7</accession>
    <name>A0A0R3X3L7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AN1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7935</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020423">
        <property type="protein sequence ID" value="VDM32411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3L7"/>
    <dbReference type="STRING" id="6205.A0A0R3X3L7"/>
    <dbReference type="WBParaSite" id="TTAC_0000795001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000795001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000795001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000795001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22241" checksum="3E336409869F0FE1" modified="2016-01-20" version="1">MEEIVRCSGCNQVFCKEHYFFDRHSCPIGNTKERQVPVCPLCGVLVPIGPNESADIKVGHHIDTDCKSQPALALKGRIFKNACSVPKCKKKELVPLRCELCHLNYCISHRNELDHNCMGLLAISANGKRMSASGAAAIKRAVARQSNNNFSDDSGALKKAQQEEVDRQLALAIAASMEAEEENRRRQRQQTSASSDNGCNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3N2</accession>
    <name>A0A0R3X3N2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7953</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUTBC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020425">
        <property type="protein sequence ID" value="VDM32430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X3N2"/>
    <dbReference type="WBParaSite" id="TTAC_0000796801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000796801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000796801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="101"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="936"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="886"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000796801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1553" mass="173662" checksum="F854BC2D0D0F671B" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4E2</accession>
    <name>A0A0R3X4E2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein grainyhead</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8259</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020473">
        <property type="protein sequence ID" value="VDM32777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4E2"/>
    <dbReference type="STRING" id="6205.A0A0R3X4E2"/>
    <dbReference type="WBParaSite" id="TTAC_0000827401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000827401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000827401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288086at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000827401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="18393" checksum="10E79C145AFF827D" modified="2016-01-20" version="1">MPDPDVFKKVEGSREEEGKEKGAGPNRIASHLTGESVKHSLVQLHPQLSSSHHLPVFKVPHGAPAGSPHTKRSALSVDGIINNSAAATAAAAAAASASNAYAAGLQAAAAAAIGLGQLADLSAVYRQATAADQVGDYHRFTEDQEGVWLGQWYQRGGLMRPQGALTAQSELMFSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4K0</accession>
    <name>A0A0R3X4K0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8328</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020485">
        <property type="protein sequence ID" value="VDM32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4K0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4K0"/>
    <dbReference type="WBParaSite" id="TTAC_0000834301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000834301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000834301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF23">
        <property type="entry name" value="LD06925P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="85"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000834301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38951" checksum="4E86CA28335D306A" modified="2016-01-20" version="1">MATANNKRTFLLERVFEESDSVAECILAWPIKSQNMIFFESRDDHFGFIESPEDWLGETYANAHGFHSSDSVQTMLENFTSSGLAEWHDFLYIRKPGEKTWTRRMCVLRNSGLYATKKNKKAFLASDLVRLLALDDKLHIYTTTGGWSRMRAPTPHGFALKTYAAQDFSSSHVFCFCAPDENALKQWACRLRLAKVRNSLLSLRSHDTDRSQISTTKFYTYGIGLLRDYQVAKERVSRGLDAGLQAQKRVTESKQSSMERARSSSFQALQPPLQRLQGSGINLGATNQVTRPLTMTPPPSAQQRIAPRTPQPPTTRRRPPDSPLHNGCTKHNSTGATSQHFYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X570</accession>
    <name>A0A0R3X570_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CASP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8579</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020538">
        <property type="protein sequence ID" value="VDM33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X570"/>
    <dbReference type="WBParaSite" id="TTAC_0000859401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000859401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000859401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000859401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11711" checksum="E909793FDA71A98D" modified="2016-01-20" version="1">MATEAMFCSRPLTVPAPHPPPPLAVPQPRIRIASDDGTFYTPIPRQRGATSESTKPSSFWTLVLLVSGSLVDLVSSLTLTFPISFSYVDARLICLLASFTAATKTATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X611</accession>
    <name>A0A0R3X611_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8914</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020626">
        <property type="protein sequence ID" value="VDM33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X611"/>
    <dbReference type="STRING" id="6205.A0A0R3X611"/>
    <dbReference type="WBParaSite" id="TTAC_0000892901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000892901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000892901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6220976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13397">
        <property type="entry name" value="ASKHA_NBD_actin_Arp-T1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000892901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42197" checksum="3A60E864BCA0AF55" modified="2016-01-20" version="1">MTSNPAVVIDVGSGLCKAGFAGEDGPISIFPSIIGRPKNPQMMVGVRKQEYFVGDAAQQMRGVLTLQYPVENGVIKNWDDIEKIWYHTFYNELRVHPEDQACLLTEAPRNPKSNRERMCEMMFERFNVPGLYIAIQAVMSLYSSGKTTGSVLDIGDGATHIVPIFEGHGLNHLVLRLNFAGRDITDYLNNLLLKRGYSLVSSAELEVVRDIKEHLCYVALDLEEEFKRAQVDPSMEKHYEMPDGQIIHVSTERFQSPEILFSPQLIGREIYGIHEALHHVIEGCEIDLRRTMYKSIVLSGGSTMFDGLIDRLQNEVTQLAAKNVKVKVNGSEKRNYAAWIGASILGSLNAFRDMVVTKEEYEEMGPRIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X645</accession>
    <name>A0A0R3X645_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8949</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020634">
        <property type="protein sequence ID" value="VDM33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X645"/>
    <dbReference type="STRING" id="6205.A0A0R3X645"/>
    <dbReference type="WBParaSite" id="TTAC_0000896401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000896401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278451at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="625" mass="69268" checksum="DC40D4BFBE4256DF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6G7</accession>
    <name>A0A0R3X6G7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9083</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020675">
        <property type="protein sequence ID" value="VDM33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6G7"/>
    <dbReference type="WBParaSite" id="TTAC_0000909801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000909801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000909801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6238928at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
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        <location>
            <begin position="691"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000909801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="747" mass="83830" checksum="6F9C9F498C7B23D9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6I3</accession>
    <name>A0A0R3X6I3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nefa_Nip30_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9103</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020681">
        <property type="protein sequence ID" value="VDM33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000911801-mRNA-1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000911801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11804" checksum="EC8FEDAD6DF6EF3C" modified="2016-01-20" version="1">MSSSLPRFISEKEIAERKLRDAAEGKKEEPYDPRPLYDRLQAERARQQEEYEASTAFKNQIHRLDADEAAFLAKIDREKCLMQESVDQEAEQLIQEAKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X748</accession>
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        <submittedName>
            <fullName evidence="6">BRCT domain-containing protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">TTAC_LOCUS9348</name>
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    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="BRCA2"/>
    </dbReference>
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        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
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        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
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        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="602"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="727"/>
            <end position="888"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000936301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1638" mass="179871" checksum="66BD0B0F4B789C68" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X750</accession>
    <name>A0A0R3X750_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9350</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020774">
        <property type="protein sequence ID" value="VDM34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X750"/>
    <dbReference type="STRING" id="6205.A0A0R3X750"/>
    <dbReference type="WBParaSite" id="TTAC_0000936501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000936501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000936501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF70">
        <property type="entry name" value="INHIBITORY POU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="427"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="522"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="524"/>
            <end position="583"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
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        <location>
            <begin position="86"/>
            <end position="223"/>
        </location>
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        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
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        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM34123.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000936501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="596" mass="66195" checksum="37AB83F396F7C378" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X783</accession>
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        <submittedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">TTAC_LOCUS9390</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020794">
        <property type="protein sequence ID" value="VDM34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0R3X783"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
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    </dbReference>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="EMBL" id="VDM34173.1"/>
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            <dbReference type="Proteomes" id="UP000274429"/>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000940501-mRNA-1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Y7</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="6" type="ORF">TTAC_LOCUS9647</name>
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    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000966201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="497" mass="53109" checksum="1EBE223C944D94C4" modified="2016-01-20" version="1">MGCVISCGLKLVLQILNTVLCVAFLAVAVFGVLLKSSKGVVEKILANVLKNEKPDDEQLQELAKFITENADGLAIILIVVGLVLAALCLIGCIASCCGWNILLKIYAAILIILLVVQIIAVAVLFSDPNRLSSWLAKSMQNLLKSYGTNSDEGKMSTAVWNCLMGMGEPTCCGFDGYSDFPDKTKLPETCCDKGANKCDKAEAEKAGKKGCKAKLATFTKNNLKAMMYISIAAILLQRGTQKAFIDIHVCLLGGTHRDCDARDLPVAFVAVAVFGILLKCSKTIVQQLLTKIFDNFNVGDEDIRQLARFITENADGIAIVLIVVGFALAALCLIGCIASCCGCNILLKIYAAILIVLLVAQIIVVAVAFSDPARLTAVLINSLEKLLQKYNETDDEGKMATTVWNVIMTVNSICCGMDGYGDFNKPGMNLPQQCCTTAITSCTAQAAQTAGVVGCREKIVTFTSDNMKILLYISISAILLQVGALTIQSPVIEQGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X889</accession>
    <name>A0A0R3X889_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB_dep_Rec domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TTAC_LOCUS9749</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021022">
        <property type="protein sequence ID" value="VDM34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X889"/>
    <dbReference type="WBParaSite" id="TTAC_0000976401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000976401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000976401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000976401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10211" checksum="0A5F0781633CF53E" modified="2016-01-20" version="1">MIPVSWKLFADTDEFVLASVVGRNLYADRAGLDSGLTIGIGTETPICPSVANEDNSDWPMRDCPIPYANGVNSLFFNETFSSAPSLANSSPSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X899</accession>
    <name>A0A0R3X899_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9759</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01021030">
        <property type="protein sequence ID" value="VDM34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X899"/>
    <dbReference type="STRING" id="6205.A0A0R3X899"/>
    <dbReference type="WBParaSite" id="TTAC_0000977401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000977401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000977401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14089">
        <property type="entry name" value="STKc_MAPKAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000977401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37497" checksum="6FD29E76821A875A" modified="2016-01-20" version="1">MLPKMVGYSFPIKTSAITHEYEITQTCLGSGINGKVLKCIHKATGKPYALKVLGDDEKACREVELHYRVSDCENIVRLVDIFENNNTNSGRNHLLIVMECMEGGELFNRIQQRHRNGFTENDAARIVYQIATAIKCLHGRNIAHRDLKPENLLFTSDAPDATLKLTDFGFAKETSKGTFLQSPCFTPYYVAPEVLGPAAYDQQCDMWSLGVITYILLCGYPPFYSQGGDPFSPGMKSRIRNGHYTYPPNEWSAVSQDAKDLINRLLIVQPQQRLTIEQVMLHPWLVRHKSVPQTPLLTLNILNEERQNWNEVQVQLKIKKLCKVVFPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8G4</accession>
    <name>A0A0R3X8G4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9824</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021081">
        <property type="protein sequence ID" value="VDM34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8G4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8G4"/>
    <dbReference type="WBParaSite" id="TTAC_0000983901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000983901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000983901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="63"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="181"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="323"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000983901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="782" mass="85569" checksum="07C5B1465A4E6602" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9C7</accession>
    <name>A0A0R3X9C7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SoHo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10137</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021348">
        <property type="protein sequence ID" value="VDM35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9C7"/>
    <dbReference type="WBParaSite" id="TTAC_0001015201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001015201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001015201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6242018at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001015201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79745" checksum="EBCC32300391640A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9W3</accession>
    <name>A0A0R3X9W3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZIP9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10323</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021550">
        <property type="protein sequence ID" value="VDM35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9W3"/>
    <dbReference type="STRING" id="6205.A0A0R3X9W3"/>
    <dbReference type="WBParaSite" id="TTAC_0001033801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001033801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001033801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133256" evidence="3">
        <location>
            <begin position="28"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001033801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="37554" checksum="9334953BEF5615F1" modified="2016-01-20" version="1">MYRKACRCSYAPIITFLLICLLPQTDHRSLHETNNIETRHLNQLEPVKQNVPPPNLNPVELPPAVNNVEETASTTKNHGLIGLALTMGFVLMFLVDHLGNEAFARPLFSVFHCFCCQRRTNDLLLPSAAALAAAEHSASTTTMGLVVHSLADGLAIGAAFGLTLDLTLILFAPAAFGFVSFLVHEGLPRNRVKVYLLIFALASPVGALLTYLVVSANAYVADQQAGFFLPSTWFFNYFLLNFNFIDELAHDTIDLTLSLKALSMGVASTSSTGTGFALLLSGGTFLYVATAHILPHLHTEKPISSSPLNGNTHHRHQSITTFKPIESIAFVFGSCVPVLISFGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9X0</accession>
    <name>A0A0R3X9X0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A to I editase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021560">
        <property type="protein sequence ID" value="VDM35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9X0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9X0"/>
    <dbReference type="WBParaSite" id="TTAC_0001034701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001034701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001034701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PheRS DNA binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PheRS DNA binding" evidence="8">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Phenylalanyl-tRNA synthetase" evidence="6">
        <location>
            <begin position="198"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001034701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33583" checksum="F10DDC7FFD5A3567" modified="2016-01-20" version="1">MDVAQIILNKLADVSPTNSQELACSLNLDHQVIVGGIKSLQQADGLVKVEPIVETSFALTDEGEYILKHGSHEFVIYSAIPDAGIPMSDLMEISKYAKLGVSKALAAKWISITRSDDNEQIDKPTGDDVQACLEKLQDCSLKERNDLKKRKLIVEKKVTVYVVERGPNFTTQRVKEETDLTSEMVATGSWQNMSFKKYNFRSLGIPPEGGHLHPLLRVRAEFRRILMNMGAVDPPTTDVLAHYSKDYVERVKRMHENGGCGSKGYRYDWKLSEAAKNLLRTHTTAVSARMLYKLAQQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAY5</accession>
    <name>A0A0R3XAY5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10695</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022067">
        <property type="protein sequence ID" value="VDM35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAY5"/>
    <dbReference type="STRING" id="6205.A0A0R3XAY5"/>
    <dbReference type="WBParaSite" id="TTAC_0001071201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001071201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001071201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10027016at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001071201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27515" checksum="9A9FFF58F3FAD742" modified="2016-01-20" version="1">MSFFGNLLKKFRQGEEKPKSKPLPSVVVVGVDPSTVWKNIAELGDGAFGKVYKASKIKTGQLAALKSVDFSSDEEMEDLMVEIEILHECKHPNILQLHEAYVYEKKIWMYLEFCGGGAVDSIMKALDKPLTEPQIKFISHEVISGLAFLHKHLIIHRDLKAGNILITLNHEIRLADFGVSARMANENQKRTTFIGTPYWMAPEVIACETFKDNPYDIAADVWSFGITLIEFAEMLPPYNELNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB12</accession>
    <name>A0A0R3XB12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022122">
        <property type="protein sequence ID" value="VDM35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB12"/>
    <dbReference type="STRING" id="6205.A0A0R3XB12"/>
    <dbReference type="WBParaSite" id="TTAC_0001073901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001073901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001073901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047184">
        <property type="entry name" value="KANK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168:SF21">
        <property type="entry name" value="KANK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24168">
        <property type="entry name" value="KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001073901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32088" checksum="A1EC23C3600FB6CA" modified="2016-01-20" version="1">MIENLAKLDVRCLHRHSTPSSLPYAINLASIAETPQRIDNERGLRMTSSESTNSDSPSSVSEIELATPLKENANGSAGHSSKEGGFCRFSDNSNQTTLVDPMTKGLTFCEWVSNQRNNNKKWKKEGAVIEKPMCLSHIGIRHTHTLDFTDFINACHLLQKSLESPKSVSSSQMMNAMPILRDYWFDNATSSTVTVEALDDLLSAIALFSPSVVGRIVNQRDKEGCTFVHIAIRKRLWRLIETALEVCREFDLNLTDACGRTPLTLMVSCASQSRTRQPGGGGGGGGGGGGGGGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBG1</accession>
    <name>A0A0R3XBG1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPK_catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10871</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022404">
        <property type="protein sequence ID" value="VDM35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBG1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBG1"/>
    <dbReference type="WBParaSite" id="TTAC_0001088801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001088801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001088801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase catalytic" evidence="5">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001088801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22805" checksum="F21794B826E94125" modified="2016-01-20" version="1">MLFGLPQGLKISVSGQNFQPSPLTSDEYHSYCQLRLGLPMVPISIIAFYLITCQNKASISIFVDGFANIIYDSPLRDSHTPNFVSGDFDSIRPEVRKATRVIETPDQDASDFTKGPSLKASIDYIVGLYGSGGRVDHEFGIINSLFIAKGVTTIPVLLVTESSISYDDILDFKKLISTSNQTIDTKVEVVSSDLLLWSISNYLIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCA2</accession>
    <name>A0A0R3XCA2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11162</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023098">
        <property type="protein sequence ID" value="VDM36142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCA2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCA2"/>
    <dbReference type="WBParaSite" id="TTAC_0001117901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001117901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001117901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001117901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15376" checksum="67720596B80BB172" modified="2016-01-20" version="1">MKLFNMYIFDVHGNNVLYKEWAKLKMTSTKENDAKLMQGMLVGLKAVCSKLSPLESGIHSLSYKTNKYRLHYFEGPTGLKIVLTSDAASSPILEDLENVYRMYVEYVVKAPGYDPSIAVASTLFSQKLEEWAQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCE5</accession>
    <name>A0A0R3XCE5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11205</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023203">
        <property type="protein sequence ID" value="VDM36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCE5"/>
    <dbReference type="WBParaSite" id="TTAC_0001122201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001122201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001122201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264129at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001122201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15977" checksum="C0887B4403AD7953" modified="2016-01-20" version="1">MYYHRTHLRDSPSYTQSNESYGSSSTSTTSTLYDGHFMSVGTISCRTPVPQHARSPRLKTTVVEPSPTKQTLRRNKSQSIVYYLWDSSGEEDDSWDYQSNSTSMGESANSCDNSVPNIVSDRSKKIDKLLHELGKPGAIRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCZ2</accession>
    <name>A0A0R3XCZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS11402</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01024007">
        <property type="protein sequence ID" value="VDM36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001141901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001141901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001141901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6279964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047163">
        <property type="entry name" value="ASPP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131:SF10">
        <property type="entry name" value="ANKYRIN-REPEAT, SH3-DOMAIN, AND PROLINE-RICH-REGION CONTAINING PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131">
        <property type="entry name" value="APOPTOSIS-STIMULATING OF P53 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001141901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17908" checksum="E6B76496EABE7854" modified="2016-01-20" version="1">MPNHCFMLGLNKFEKLVSDVSEANDEGITALHNAVCAGRAEVVEFLVCEAGADVNAGDTDGWTPLHCAASCGNVRLARLLVEHGAALHARTLSDHETALEKCDQADADAECERYLSAELERLGSADNGRVFALFPRGLEAAGPGSPDANIEPDELPIWPNEELRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD32</accession>
    <name>A0A0R3XD32_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11442</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024211">
        <property type="protein sequence ID" value="VDM36507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD32"/>
    <dbReference type="WBParaSite" id="TTAC_0001145901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001145901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001145901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133284" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001145901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10364" checksum="EDF88808A6CF8998" modified="2016-01-20" version="1">MVRPLLLFASLKHLCSHLTNFGAPKPFVTVTLTYRTPNKEPIFTFAFPPTPTPFLMKVMASYGSCCVDVSDSLLRHSRRRAVCRIHADWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD78</accession>
    <name>A0A0R3XD78_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IBB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11488</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024421">
        <property type="protein sequence ID" value="VDM36663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD78"/>
    <dbReference type="STRING" id="6205.A0A0R3XD78"/>
    <dbReference type="WBParaSite" id="TTAC_0001150501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001150501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001150501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001150501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39844" checksum="E1A605C7635699F2" modified="2016-01-20" version="1">MIDLSNKQNIPADVSAEAEVEVVEKPPLLNLPDIVENANSEDPAVRLLVVQSARKLLSSDRHPPIDELINCNVLPMLVNCLDSENPTLQFEAAWALTNIASGNSKQTAAVVQAGAVPYFLKLLSSPHMNVSEQAVWALGNIIGDGPQLRDLVIEQGLIKPLLNLLTPNISITFLRNITWVMVNLCRNKNPPPPVGTIQELLPALLYLITNTQILVDTVWAISYLTDGGNYLISMVINAEIVPHLVPLLSHPNFKVQTAALRAVGNIVTGTDQQTQVVLDCGALSHFPQLLNHPKEKINKEAVWFLSNITAGDQSQVQAVIDHNLVPLIIGHLANSEFLTQKEAAWAISNLTINGNEQQVIAISSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDA1</accession>
    <name>A0A158RDA1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS215</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000014">
        <property type="protein sequence ID" value="VDM16085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDA1"/>
    <dbReference type="STRING" id="6205.A0A158RDA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000021401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000021401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000021401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000003">
        <property type="entry name" value="recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000003">
        <property type="entry name" value="Related to J kappa-recombination signal binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="611"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="773"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000021401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1171" mass="124717" checksum="A52BDEC3F05FCCED" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDH1</accession>
    <name>A0A158RDH1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS614</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000065">
        <property type="protein sequence ID" value="VDM16744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDH1"/>
    <dbReference type="STRING" id="6205.A0A158RDH1"/>
    <dbReference type="WBParaSite" id="TTAC_0000061301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000061301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000061301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00023">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="789"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="897"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000061301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119043" checksum="9E407AD0A0EEFCC3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDH2</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">Centrosomal protein of 97 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS619</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000066">
        <property type="protein sequence ID" value="VDM16749.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDH2"/>
    <dbReference type="STRING" id="6205.A0A158RDH2"/>
    <dbReference type="WBParaSite" id="TTAC_0000061801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000061801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000061801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275978at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000061801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="642" mass="70148" checksum="9684523B6523B52B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDS8</accession>
    <name>A0A158RDS8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein lap4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1482</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000336">
        <property type="protein sequence ID" value="VDM18080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDS8"/>
    <dbReference type="STRING" id="6205.A0A158RDS8"/>
    <dbReference type="WBParaSite" id="TTAC_0000149501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000149501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000149501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000149501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="520" mass="57512" checksum="2EE9CC2CE56E3510" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE96</accession>
    <name>A0A158RE96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6910</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020331">
        <property type="protein sequence ID" value="VDM31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE96"/>
    <dbReference type="STRING" id="6205.A0A158RE96"/>
    <dbReference type="WBParaSite" id="TTAC_0000692501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000692501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000692501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF2">
        <property type="entry name" value="BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="285"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000692501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="665" mass="73484" checksum="FB805C5BA84F0E5D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB0</accession>
    <name>A0A158REB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6979</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020336">
        <property type="protein sequence ID" value="VDM31277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REB0"/>
    <dbReference type="STRING" id="6205.A0A158REB0"/>
    <dbReference type="WBParaSite" id="TTAC_0000699401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000699401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000699401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000699401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54159" checksum="985CB0C3D8D1CFF0" modified="2016-06-08" version="1">MGAEVLQIPESFEDSTKAFLIGLLQSNIEVRLGCQGRGSEELMTHSFLANMDWEMAKRQRLQPPLIPPQGEVNAADAFEIGAFDEEDTQGIRVRIQILILTEEDQQVYKEFDVVIADRWQHEMTTTIFDAVNEDFDQMESKRRAKLQQRLNQLTHTLASQPEGETTSVVSGLPSASPSLSRSASATTMTASQQKSLDHEDIPSWPAELLLEWWIDPERYGCGPSDCLVESELLRLGGPFLHTWQKKHVRLFPNRLEIYVKNQHGIPLKGAEFISMLDIASIYPTLQRINKYDGVIIVVLKSQSKIFLTSQDQIVVEQWLNVLLRAFEASSQVLSSMSRKVYWIYGIDEPKLYARASPSCSNSTQLPPPPPPPLGVTQPDLAAKRKQFRRMQSFQTALTARNWSPPPPAPPSPPAPTSVVASSTSQPPAVAETTSARRAILKNLNKMGFSRSQDVSSPLPPPPQPSSPLLECTKSSSAADNGGGHQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REE2</accession>
    <name>A0A158REE2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7119</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020347">
        <property type="protein sequence ID" value="VDM31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REE2"/>
    <dbReference type="STRING" id="6205.A0A158REE2"/>
    <dbReference type="WBParaSite" id="TTAC_0000713401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000713401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000713401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000713401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="669" mass="74000" checksum="5AB0C82D72B6B1E1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REQ4</accession>
    <name>A0A158REQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7808</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020407">
        <property type="protein sequence ID" value="VDM32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REQ4"/>
    <dbReference type="STRING" id="6205.A0A158REQ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000782301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000782301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000782301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261060at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058666">
        <property type="entry name" value="SASH1/NUB1_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26285">
        <property type="entry name" value="SASH1_Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000782301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="785" mass="88547" checksum="DCE94A129EA01998" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REU1</accession>
    <name>A0A158REU1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS8055</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020438">
        <property type="protein sequence ID" value="VDM32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REU1"/>
    <dbReference type="STRING" id="6205.A0A158REU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000807001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000807001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000807001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001170">
        <property type="entry name" value="Ribosomal protein S6 kinase alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="306"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="387"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000807001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="710" mass="79462" checksum="26CF099A4B0BB39B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REX1</accession>
    <name>A0A158REX1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8241</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020471">
        <property type="protein sequence ID" value="VDM32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REX1"/>
    <dbReference type="WBParaSite" id="TTAC_0000825601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000825601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000825601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2281547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051999">
        <property type="entry name" value="Mediator_complex_subunit_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="11">
        <location>
            <begin position="324"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="871"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1470"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1514"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1258"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1307"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1390"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1470"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1520"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1551"/>
            <end position="1603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000825601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1610" mass="168296" checksum="907709A12098B1F8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E716</accession>
    <name>A0A3P7E716_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000151">
        <property type="protein sequence ID" value="VDM17283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E716"/>
    <dbReference type="OrthoDB" id="6416209at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25483" checksum="0EEEABC583BCFD9A" modified="2019-02-13" version="1">MIGQAFYQWMMRYTLECASTPATSADLRSSVLTSPLRLTIIGTLSFVLGEAIGATLNLLGVDVDRSLSMARIYCDHHQWVHSSTSVEASYARITGALFGLAGALSFRPLTVRNVKPPPITVKRVIFPCIMCIIVCYYWQRCVSFIAPFFKCLLGYIPLRTEASFLFYMGIIGASCPIIVALFFSSLLDQLVHCKASMCNTSKHNTNVDFSRQGSQASTRSRRSHSRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EB02</accession>
    <name>A0A3P7EB02_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin/FtsZ 2-layer sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000490">
        <property type="protein sequence ID" value="VDM18493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EB02"/>
    <dbReference type="OrthoDB" id="6257981at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="258" mass="29274" checksum="977D544D980673F6" modified="2019-02-13" version="1">MLQLQTNLVPFPRLRYLQLGLAPLCTADVMSHEAFTVPELTLKCFEKENQMNTCDPKNSVMMACALLYRGDVPIKEITDSIEIFKKRSIVGLVDWCPTGFKVGVVERPPAVVKQSGMGRTCRQLTAIYNSTLVIEPFKCILHRFNTLLAKKAFVHWFLQEGMEEAEFCECADDVQAIMNDYIFIENCFNTGAECAEPPIVDRRFNNPCRPQEEEEEEEEYAADDCMNCDLDDMFGDNDDGCDNDSANYLAESLNGRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EQI9</accession>
    <name>A0A3P7EQI9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS1877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000576">
        <property type="protein sequence ID" value="VDM18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EQI9"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="491" mass="53142" checksum="27042A4989AF0925" modified="2019-02-13" version="1">MLPDALVEASLSLSELASSEFDSVADITIPDILSVFTSDGSDPGSFQLVSMDVSITTSLTSVQSYRNAREFSEDDVDSELPISSSSDEDSVRQPVAAPPVHISKVFDLPLDIDPKYVPRLPRLLSEHVKLGVLGKVSSVIKGCVVIASLPNLSPLDKGSALYLQNRRPLGEVYDTIGPVRSPFYVVVHENRQPPSRPLKARSERTTVNDTTASTTVTCSAAAMTEARSAQDLPKLSVEVSVGDEVFYVLDDPALSIKILCSELSKLRGSDASGLKDEEISPDQQDFSDDEKEYAHRRKLEGKRSNCANRRGWGGSGFNNGRSNHLSRQGAFRSGVGVVSRPRGGVGGCVPSAGLRNAYSSGRPITYQQSLPPSTQRGVLRPSLLGSHQTISRQSMQFIQHQPISFASWNVAPMSYAYCGPQITGWEFTNRSYFPQHSAIPLGVSPLNLRQTAVQGSHRAIYEGNFDGVVDPTPLPAFTTGTPPHQEDPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXH7</accession>
    <name>A0A3P7EXH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009864">
        <property type="protein sequence ID" value="VDM28021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXH7"/>
    <dbReference type="OrthoDB" id="6241283at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="216" mass="24476" checksum="2998961BD2AFD3FA" modified="2019-02-13" version="1">MRQESRSFGLVNPLGDLGCNDAAQQLNIEKAITPADLGDGGRKYLFEVDLSTATDLSPCSNKTLDESETTPIEMLPVAPLPSPPIITFTSCDEEAEQKKYCEFGKVPADWTSSCPSSTLGVFQLDNGEYILSMLIYKYGEDQRLWRQWLKRVEKTMLGLEKSCKCKITLYNKPFRFRGVMTHMIRIRGLSKRSVIRCKNALPSYIQDRLITAHAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXN7</accession>
    <name>A0A3P7EXN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006016">
        <property type="protein sequence ID" value="VDM26113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXN7"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="209" mass="23648" checksum="CC6326A12AE1670E" modified="2019-02-13" version="1">MEKHKHIAILGHVFDVSSNQRIYGPNGIYAPFTGRDATRMLVSEGMKDSGLEAYALDGLTSAQLYELGDWLKLYTRKYPCVGYIPSVYRSPMGDASNLLIELLNTWNKQSPKSLDFLELLPPCNSFFDGKLLRLTCNPYTSDTSEELYPRQLLEPEKARLRCACVPTSYLTHPRLRLYPDCPGIADHCLIKIDDPESVWTSRLASIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EY53</accession>
    <name>A0A3P7EY53_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010340">
        <property type="protein sequence ID" value="VDM28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EY53"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018026030" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7539" checksum="29BC720EBE2D1DBB" modified="2019-02-13" version="1">MLSVADVALLLWVVVIVEGSGGICAAWLESRECMVRKRTEVWDRLRPRCLLVVSRSLVDERWLAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F249</accession>
    <name>A0A3P7F249_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009363">
        <property type="protein sequence ID" value="VDM27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F249"/>
    <dbReference type="OrthoDB" id="6817893at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042620">
        <property type="entry name" value="NSUN7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663:SF2">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19157" checksum="D3D5A56549F6FF8D" modified="2019-02-13" version="1">MCSLDYNILDKIVDEVGFYGEYPDLREEEYLVLVTLYDYTARSYQRRTSTDAEVEAVTVDEVDTKSPRFAGRTIIYPPTLEAFQVLSRVFCYPVGLITYTAVEQAVIDMSVHFAAAVARTRVKEQVGSLHLLLPAEWREAESMAENMPFYGWYNQLLGKYVKSHDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FBP6</accession>
    <name>A0A3P7FBP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006066">
        <property type="protein sequence ID" value="VDM26149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FBP6"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="64" mass="7150" checksum="4F2C722287F8C7AA" modified="2019-02-13" version="1">MVKHHAAQLDGFLTLARFPLDRPAGESPLVLQGVRSDELEEKLRLKAMEMGLKLCHVLSINLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G631</accession>
    <name>A0A3P7G631_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RNA helicase DHX37-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000383">
        <property type="protein sequence ID" value="VDM18228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G631"/>
    <dbReference type="OrthoDB" id="10025033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase DHX37-like C-terminal" evidence="1">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="200" mass="22385" checksum="0F5AE542DBE627A4" modified="2019-02-13" version="1">MLATGTDVGKEDEKAFTQPSIATVEQCPPPFYDTKHDAVLVYAKRVTFVGANFEVEVAASAAKGSTENGFELPALHTPFPLTAGPAIASLGDHECLVWSVRWFARFLLEGKVYPKRLAAWFPKSIKTSTPTRMITLSWGLVRSEVRGLISKMLSEKVNSKRALEECLAKNPDFLSRELMAWLPINCHTDFLLKWHSFKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GKU2</accession>
    <name>A0A3P7GKU2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01002223">
        <property type="protein sequence ID" value="VDM22365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GKU2"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="254"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM22365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="406" mass="47495" checksum="EABB8EB2C45A7CDF" modified="2019-02-13" version="1" fragment="single">MPDEDADDVMREYEEEERDRQNDIKERDAFVQRLLSRDGESTKKVVRGSRLEEDLKRLERGEVTREELLVELKKKSRWEYLKKRQLDKLQDLEAEIRDEETFFGEEELTERERTELKYKRTILEAANAHKVVTAEQNAQHYFIPTENKRPDDTYYETEVEKGPHGENRRWEQEHLSSALFKIGAKDSKAKEKYELILDDEIEFMKALTQPGSNVSLEPELTPEEQLRRRSEEQKKSLQETRKSLPIYNFRRALLDAIKDHQVLIIEGETGSGKTTQIPQYLYEAGYCKAGKRIGCTQPRRVAAMSVAARVAQEMSVKLGFEVGYTVRFEDCTSDRTILKYMTDGMLLREFLSEPDLASYSVMMIDEAHERTLHTDVLFGLVKVNLLHLVLSMLHRLIFLTNGIHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHP4</accession>
    <name>A0A0R3WHP4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS73</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000005">
        <property type="protein sequence ID" value="VDM15793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHP4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000007201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000007201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000007201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM15793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000007201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16272" checksum="7229ECFEEAD7229B" modified="2016-01-20" version="1">MKKLSFECINKHKANTGGIIFVIDSTSIQDALMDTAEYLYDLMTDATLARSHVPFLILCNKKDLPNAKDPILIERMLEAELTTLCRTKADALAGLDGHQESRVPLVKNSCKEFRFAECKHHSVTFADCSATSTDISPVRLWLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI85</accession>
    <name>A0A0R3WI85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CNOT1_CAF1_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000021">
        <property type="protein sequence ID" value="VDM16209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI85"/>
    <dbReference type="STRING" id="6205.A0A0R3WI85"/>
    <dbReference type="WBParaSite" id="TTAC_0000029501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000029501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000029501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000029501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26107" checksum="87CBA43FB7CF6F9E" modified="2016-01-20" version="1">MSSRAAFRSIPQPPERLSKKICFILNNLTEHNLKSQTHELMSQLPLHFNRWLAEFIISRVATESNLVDMYTEFVLLATNRQNNFRPLILDLLTREIDFLLRPGQLNSTNGRSLKNFGAFLGRLTLAKGIKLGVDLKSLIYVAYKNRPESLDYIVPFICELLKNIKHSGSFRELDPWMREILEVTKELHDNTDKLPIQFEVELLFSYLECDMSEIATAFYLRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIA3</accession>
    <name>A0A0R3WIA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS317</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000023">
        <property type="protein sequence ID" value="VDM16238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIA3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000031601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000031601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000031601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007415at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000031601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17863" checksum="773D0A505F83FEB8" modified="2016-01-20" version="1">MESLPSARIVHLYRWQGANGYGFVLKEEKSKKEFCIKSVEAGLPAEAAGVMTNDCVIEVNGRLASSMTYNDVVEEIKRDPQKVTLMLLQPYEKQVLKRRGIELSSKTCSAQIVIGRRQRDDTTSMVCEKMSADTISKSLINCDAGTAAMLNKQKLDLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIT3</accession>
    <name>A0A0R3WIT3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynamin_M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000049">
        <property type="protein sequence ID" value="VDM16589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIT3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIT3"/>
    <dbReference type="WBParaSite" id="TTAC_0000052901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000052901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000052901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000052901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7887" checksum="B03F30F60C77B140" modified="2016-01-20" version="1">MASATQLDGVAQLQYSKHDSEAGRRVEALTEQAIRRLQQRFEDNKEAALEGIVAQVLSVCPTLHRNLVSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIU7</accession>
    <name>A0A0R3WIU7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS550</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000053">
        <property type="protein sequence ID" value="VDM16628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIU7"/>
    <dbReference type="STRING" id="6205.A0A0R3WIU7"/>
    <dbReference type="WBParaSite" id="TTAC_0000054901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000054901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000054901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="228"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000054901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51816" checksum="9DD5826D54699DB9" modified="2016-01-20" version="1">MAEYDLTKTISQYLDRHLVVPLLEYLSVKSIYDNDSILRSKLDLLMKTSMVDFTCLTYRLLHKVEDVPEELIKKRQDTLDLIRVMEEKMAPIDKIFSTETMKEMVQCKVAKELFQNLEAKYGFKPEMLDDMFEAARIFYDSGLYDTASDYLRIIRQLVSPTDKRHLHACWGRLAAEILVQNWDEALDDVEKLKDAIDCQSDDRLRPSAETYLFQLQQRTWLLHWSLFVFFNHVQGKEKLIDFFLNNPNHLNAIQTLTPHLLRYLAVCVVVSNDKRKKNQLREVVHLIQQESYCYKDPITEFLACLYVKFDFDGAQQQLKICETVIPNDFFLTGCYEDFMENGRLLMFETFCRIHNCVGIKMLAEKLNMNVDDAESWIVNLIRNAEMDAKIDSKKGLVFMGTHTVSPYQQVVEKTINGAFTAHKLLDRLKNSKVDAESWSATSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ03</accession>
    <name>A0A0R3WJ03_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS622</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000067">
        <property type="protein sequence ID" value="VDM16753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ03"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ03"/>
    <dbReference type="WBParaSite" id="TTAC_0000062101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000062101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000062101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="77"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM16753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000062101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38639" checksum="6E55FC0925AE983C" modified="2016-01-20" version="1">MESKRVLSIQSHVVHGYVGNKSALFPLQLHNFEVDSINSVQLSCHTQYAHCTGQVLSSEHLKSIYDSLRLNGSASYDALLTGYVGDPNLLIQLAEIAAGIKSATPHCDPVIGDNGHIYVPKDLVPIYREKILPIADVLLPNQFEAELLTGCKITDEDSVFHCIDVLHSTHSIPTIILSSTELFFEDEQGLKQLATYISYRPDLAVLRKRGEFNGDLCQKGKETSEIKSFSICAILRVTPQRVRALYPKLEATFFGTGDLFSSLTLIYFEKHGGNVDIRKALYKIQCTMHAVLKRTLDYAENLNSGQPVANPANIMQKSDRYELRLIQSAKDILDPPEYASIQVTSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJE8</accession>
    <name>A0A0R3WJE8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SUFU_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000100">
        <property type="protein sequence ID" value="VDM17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WJE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000079601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000079601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000079601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038834at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.230">
        <property type="entry name" value="Sufu, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024314">
        <property type="entry name" value="SUFU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038489">
        <property type="entry name" value="SUFU_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037181">
        <property type="entry name" value="SUFU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007768">
        <property type="entry name" value="Suppressor_of_fused"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928">
        <property type="entry name" value="SUPPRESSOR OF FUSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928:SF2">
        <property type="entry name" value="SUPPRESSOR OF FUSED HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12470">
        <property type="entry name" value="SUFU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103359">
        <property type="entry name" value="Suppressor of Fused, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of fused C-terminal" evidence="2">
        <location>
            <begin position="310"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000079601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="593" mass="61883" checksum="69CA62678E6B5768" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJF8</accession>
    <name>A0A0R3WJF8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ASXH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS807</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000359">
        <property type="protein sequence ID" value="VDM18156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000154201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000154201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000154201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="480"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000154201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="609" mass="67770" checksum="B862C07A8230B06A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM65</accession>
    <name>A0A0R3WM65_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1840</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000547">
        <property type="protein sequence ID" value="VDM18580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WM65"/>
    <dbReference type="WBParaSite" id="TTAC_0000185301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000185301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000185301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283009at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1657"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1756"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1660"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1756"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1775"/>
            <end position="1795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000185301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1830" mass="203367" checksum="B248AFCAFA90C1F4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMH4</accession>
    <name>A0A0R3WMH4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydropteridine reductase</fullName>
            <ecNumber evidence="7">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HDHPR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1949</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:17871"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:17867"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01000628">
        <property type="protein sequence ID" value="VDM18689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMH4"/>
    <dbReference type="STRING" id="6205.A0A0R3WMH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000196201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000196201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000196201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000196201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25196" checksum="E11005426E6A8194" modified="2016-01-20" version="1">MSSSVIVYGGNGGLGSSCVSFFKKYGFWVCSVGWKENVQADANVIITKLDSLEEQYHEVAEGLKEILSGSLVDGIFCMAGGWVGGNCSTEGFIKSVDIAIKQSVWPSAVAASVSSIYLRSGGLFILCGSIAALDGTPKMIGYGLAKAAIHQLTASLAELDSGMPPDCYVITLLFGTLDTPMNRKLMPKADFSTWTPLDFINRLLLDWIQGKVRPKSGSLVKVMTINGRSECMPCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN22</accession>
    <name>A0A0R3WN22_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pellino</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2147</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000801">
        <property type="protein sequence ID" value="VDM19041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN22"/>
    <dbReference type="STRING" id="6205.A0A0R3WN22"/>
    <dbReference type="WBParaSite" id="TTAC_0000216001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000216001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000216001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8801906at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="4">
        <location>
            <begin position="300"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM19041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000216001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52403" checksum="7C17A95B883B48D6" modified="2016-01-20" version="1">VVVNPNRHAVSFTFNRTNTVVVEYVPDPNTDLFQIGRYKSPIIDFHIGDVASPTEDRSTNRSSPFLYRGRGRFFLGMFDRPSFSPKKPMGALSTVSRFACRIDIDRRPPHKARIYAAGFDMRNNIFLGENACKWRHSDIMDGFTTNGVRILRPSQWLKRGETGDALLYLMPNFDALFYSSLWREVSVCGNVYKLHSTMFVPGETDRVKDEDNVLEDGTLIDLCGAILIWRSADGLKNGLTLTDISEMVNILNQLHIQCPVYLKTLHFKGFGTPRVPSKHFYHAMSGQDFPSSSISATFGGGSQPHVYLNCGHVHGYHDWQPNDRQSSSERDKRTCPLCRQTSQFVRISIGEEVGFFVDRGAPSHCFNPCGHIASEATVRFWSTLKLPVTSQTPMVPKCPFCFHVVEGPPVRLIFQHRADESTLKEAFEAFNCTPLDSPHRATPFVFNSASPPTTPTVPTLVDSDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPE8</accession>
    <name>A0A0R3WPE8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2623</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001293">
        <property type="protein sequence ID" value="VDM20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000263801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000263801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000263801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000263801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33731" checksum="CEE455805343EA21" modified="2016-01-20" version="1">PITQKKVIKAKKIKEVKTQDVPLLPEKGTKGKGRSKVAPLPDIIKKKVVPEVKKRPRKNPLIQKRPKNFGIGQAIQPRRNVYRFVKWPKYIELQRKKAILKKRLKIPPPINQFSQALDRATCKIVFNLCSKYRPLTKQAKKALLTHRAQKRAGGGADVPQEKRPYFRSGVREVTASIMSKKAQLVLIAHDVDPIEIVLFLPALCRKMGVPYAIVRGKARLGQLVRRKTCTCLAFTTVKAEDKPRLAKIIQTVKTNFNDRYDEIRKHWGGGIMGSKSLARVSKLERAKEKELKLKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPR6</accession>
    <name>A0A0R3WPR6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2741</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001457">
        <property type="protein sequence ID" value="VDM21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPR6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPR6"/>
    <dbReference type="WBParaSite" id="TTAC_0000275601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000275601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000275601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132977" evidence="7">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000275601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="481" mass="52355" checksum="99B47AA1D6E7BB30" modified="2016-01-20" version="1">MASVWGFLTVLGAALIHLSLGYNYTVGNMNAYLIPYMGVTSGQTVWIHAVVISGQAIGMPIGGMLTAKIGFRIVVAIGCLLTSGGIALSALTVRHGLGPFIFTYAVMFGIGMGLPYSVLFTLAADWFPKHRAVVTGIILGGLGMGALVFTPTQTALINPENKPNFDPSVKARVPNSFLILAAVMFGLQIIGYCLIRKCPSSDGDGTDIFSESKEFEHKEDPDFESEAAVNIKESEVHEIYNYTVKEALKSIDFYTIALIIFFDTVPITLQSSAYKVFGSANNLEDRFLSTIATCTAIFNCSGRVIWGLICDHVSFKIPLGCFLVIWGVLFGTFPVIARAPTHVFQGLYPVWVFLLFFSMAGHFVLMPAACSRIFGPKNTATTYGLLYFTTCPSALILAAIVSVHDIKNDFPLTFYCCCGLCLLSFVLSLFLKDKFGKLSNVTRLCTNACNICRYVPPAVKDVDDNDDAEVSVVSNNRIYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPV3</accession>
    <name>A0A0R3WPV3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2778</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001497">
        <property type="protein sequence ID" value="VDM21135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPV3"/>
    <dbReference type="STRING" id="6205.A0A0R3WPV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000279301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000279301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000279301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6275562at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133030" evidence="2">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000279301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15240" checksum="81C2672AFC5F9D73" modified="2016-01-20" version="1">MGEGGLDSHCIITFILGTLSILTTTSKGESSSNLPSNPASTSNLGSGQRRAKSLVPLSENSDWWKVVDNGEEEAGSSPGPLIPDPGYVNGVDSALIPLLDGLVHNISCSWFFDNPPEPRLETQSTADPLTAPGLLLEFDFDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPY2</accession>
    <name>A0A0R3WPY2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2807</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001532">
        <property type="protein sequence ID" value="VDM21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPY2"/>
    <dbReference type="STRING" id="6205.A0A0R3WPY2"/>
    <dbReference type="WBParaSite" id="TTAC_0000282201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000282201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000282201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF62">
        <property type="entry name" value="GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000282201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45346" checksum="58BE4AABB1120F9C" modified="2016-01-20" version="1">MTYIYRNNAGRFRLEPGVHTFLPPTVSAPGLNANLYIPSTSSSSSTWRPARGFFSGPAAADSRDFLLQSSSLQESCPSINLLSSSGIRNSVTTPAALRKPHSSSAPSEGITGVEPAFSPPIHMLRIMRKRSTSRRPPSLSGGGPVHLENPERETRWYFKYFLGKGDFSFNTFWQLRTHQIYCGNISEKDPLLLAVVKSEFEAEGLRQYRAILWTNLFDIYRLEKGLKEILHYEVQKEVLTLEEQEGSVNFKFGVLYCKEGQTSDEEMYNNENGSSQYQAFLRLLGDRITLKNWDRFKGGLDAKTETTGTESIYTIYEGHEIMFHVSTLLPISTDNRQQVISNRGYLQPKAKHSLFKHQIERKRHIGNDIVNIIFFDASDVEKPLSWGPSMMKTHFTRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ41</accession>
    <name>A0A0R3WQ41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Yae1_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2866</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001607">
        <property type="protein sequence ID" value="VDM21364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ41"/>
    <dbReference type="WBParaSite" id="TTAC_0000288101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000288101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000288101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000288101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17675" checksum="84A725B896F95D55" modified="2016-01-20" version="1">MRSEGTDFLDEILMEEQKQYSKAYSEAFQLSSQATPSSELADRSDELHSAWIHGLQCGAQLGAELFSYKGLADEVVASSTLRPVSPSVEEVNKHHPICIAQQLLHLLTNPPGPLSRSCQEFVKDPTSETNLSLIRNKAKQLKAALRIPTARKTTENYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRA1</accession>
    <name>A0A0R3WRA1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002170">
        <property type="protein sequence ID" value="VDM22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRA1"/>
    <dbReference type="WBParaSite" id="TTAC_0000329101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000329101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000329101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288072at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000329101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23722" checksum="F8424D085F7C8769" modified="2016-01-20" version="1">MLLLKPLPLSILQVMPESLGGGQRGVDSAHVNPNRGPDIFWTTIFIFLLTVLLMVLIQVVNFCYCCRKRIAPHGSMNVLQLAALGSDFSNGWLIFRIVYIVALVIALAFLFVSTILLIVYFHSTGLVAAYLETAPQPSTGRPSSVSLPDGLHSTMLHASSFVRDGIEKGRGLTNTTLRDLFDRADVSQSNSCLNYCEEWGFCWNFDPNALIILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB7</accession>
    <name>A0A0R3WRB7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3293</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002197">
        <property type="protein sequence ID" value="VDM22332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB7"/>
    <dbReference type="STRING" id="6205.A0A0R3WRB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000330701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28800" checksum="B4F0AE880BC1398D" modified="2016-01-20" version="1">MVKTKTSTFCRNEDNVTGLCNRHSCPLANSQYATIKERDGIIYLFVKAPERVPYPSKQWERIKLKKNEDQAIEQINEHLRYWDRWMRARVKLRYLRTRDYLKHMRRLALSRQKKIETINKKSERRELRREEKALRVAKLSRTVENELLERLRAATSSKEIYNIDQAAFEEALENEELEEPEEEEEEVVYTSASEVEEDEDLEDFGVIQEMEDQPEMVTVRTNPPPSSSKRQKVTIVYEKDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRM9</accession>
    <name>A0A0R3WRM9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3405</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002383">
        <property type="protein sequence ID" value="VDM22563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000341901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000341901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000341901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132966" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000341901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9052" checksum="1A02D77853BBF8A7" modified="2016-01-20" version="1">MSPSHLFDLALLLTAFAAVDSLKIKLREEGLRTIPSETQPSFLKRLQALRDGDVDIPALFELYELEKRRTMPYSGGIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRP1</accession>
    <name>A0A0R3WRP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DSHCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3415</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002398">
        <property type="protein sequence ID" value="VDM22583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRP1"/>
    <dbReference type="STRING" id="6205.A0A0R3WRP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000343101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000343101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000343101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase Ski2/MTR4 C-terminal" evidence="5">
        <location>
            <begin position="234"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM22583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000343101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47038" checksum="3E939AF640DFBA4A" modified="2016-01-20" version="1">MVDVLVRVVTSNPDCVTIEPSPPALTSFKPVGEFDLLVRDEGTIVETAEPRSKKRRRSLKGISKAPEQNQKPIDSVYAAIIASVPLDCLREMSLVCLNFSCIDGANVKDPAALVEKVAKLPSSMRLHFWEGIHRAKSKLGGQLPLIDPVKDMGVKDSRLVTCLNNIHLLQARIMLNPLYNRKDLDYLLHTHKRRIGKYLELRAAHDELRQKESLLQLDELHSRKRVLRRLGFSTEDDVIHLKGRIACEISSGDELMLTELLLDGFFSNLSAEQIAGALSCFVTEKGSTKVPPKLRPDMEAALSVIRSKARYLATVAEESRVRPGPMALTPGGAIKGDGNIFAEGGQSAVDDYVAKFSGEMMEVVRSWAQGVSFAELCQMTPLFEGNVIRCLRRLEELLRQMHEAAKVAGNADLENKFVKGELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRR9</accession>
    <name>A0A0R3WRR9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS3443</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002441">
        <property type="protein sequence ID" value="VDM22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRR9"/>
    <dbReference type="STRING" id="6205.A0A0R3WRR9"/>
    <dbReference type="WBParaSite" id="TTAC_0000345901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000345901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000345901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6288602at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000345901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="201" mass="21159" checksum="21315E56FEC35D53" modified="2016-01-20" version="1">MAHTPTVTASSSPHQNSSLSHFPSTSLDVSTSGGLSGHWASGGLSVDEPDSSSATLHPTYALLSAPTTLPSENSQFFHKLPDHQMTTSTSSNGNNYFIAMDGGGEYYSHPPSSSSAFNQLPPPTEQNRQLTDLDSANKGPSRSTGGVSLPGFTSPESAFYQYQNRMEGQLCQICGELAAGFHHGAYVCEACKVCAAIKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRS2</accession>
    <name>A0A0R3WRS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3446</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002445">
        <property type="protein sequence ID" value="VDM22646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRS2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000346201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000346201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000346201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM22646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000346201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="24922" checksum="55812BCF71FCFF55" modified="2016-01-20" version="1">MCAETSDGSYFCGCHKGYELNPDGRTCSPSEACDPPCMGKAQCFRGRCICPTGFQGPRCDVDIDECAMPAYVHGCAHGCRNLYGSYECICPSGYTLMSDKRTCVVADPSNDCISPCKNGGVCRGNNQCSCPRGFEGSDCSQDIDECVTLAPCDPDFGICINRYGGYECVCQPGYILLLDGRHCIQEARARQAPHLVFRGRGVKGITLGTPVEPRLSLQDSHLPTLKRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRV4</accession>
    <name>A0A0R3WRV4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3479</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002503">
        <property type="protein sequence ID" value="VDM22714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRV4"/>
    <dbReference type="WBParaSite" id="TTAC_0000349401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000349401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000349401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000349401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50579" checksum="89282EE21A98F6F4" modified="2016-01-20" version="1">MCECRLGPLDLNNADHNFLTPSQDQTSASCDLAFKFIEIQQCCHLTFPDRNNYNEFPRLCPVHGCLSKPCVEEEASCMEKCLLHCHSKSPHNLYAIENGLPKATDSVEDYLKYIHDCDFAHSRSSLGNPGSATDPFEKRVGALQVNSMASRPRSPVFTATFSFRSRRVGEAGPAKPTFLEGVRSQAYKYCRDLGLVDETARLFVAELRHTFPEGYVERPTWQHVTLFFRPNTLEHLMLRAFPGDKYFVCGIRYQDFNNPVDLHFGDQVVEIMPIWMQEQIKDASQQRSHSDNADGFQAMIIPSPFLRKIELRVYDCPIINEFNIKKRTLENARSNRDLGLAIHRGRVVYIDKASPAKISGLEPDYQIVEVAGESVLEYDDSHIIRLIRTAIRRSLTRAVELAVIPSQFYDVLMDPRRGEVYTLVRDAEFDVNAWSDNKVFGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS21</accession>
    <name>A0A0R3WS21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3546</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002619">
        <property type="protein sequence ID" value="VDM22845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS21"/>
    <dbReference type="STRING" id="6205.A0A0R3WS21"/>
    <dbReference type="WBParaSite" id="TTAC_0000356101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000356101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000356101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="115"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000356101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65334" checksum="07966FCE63E1CE77" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS42</accession>
    <name>A0A0R3WS42_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clathrin assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002645">
        <property type="protein sequence ID" value="VDM22882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS42"/>
    <dbReference type="STRING" id="6205.A0A0R3WS42"/>
    <dbReference type="WBParaSite" id="TTAC_0000358201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000358201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000358201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000358201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20047" checksum="2D4068BD2E945F16" modified="2016-01-20" version="1">MTTGKAMRYNGMPMGPPSNMLASQPNFTMDFGAQSSMPNVVQQGNQQMMMPMGGSAASNQVVVQTDSTQQQMVVQPANYFQSLVQPATSLSGSGVQSGVVSSSSAPAPVASTAVTMTSTAVPVAVPPAANVTIDENGPFVLPDPPSDHQQERDQVNLAYTHICLISLCGEILMHLGGNVRRQVCLSDFTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSL3</accession>
    <name>A0A0R3WSL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002954">
        <property type="protein sequence ID" value="VDM23256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSL3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000375301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000375301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000375301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000375301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17234" checksum="88298D653AEDDBB0" modified="2016-01-20" version="1">MRAILCCKATEDASTSRLEGRSKANAASTTKLSKSEETKSNHQSMKHWLLDKYEEIINEEEVVDSKIRQFPSLKKPLKAKKHLSKNAAIEEKKEADVELKKPPRVRGKRRPSKGAADMGANVSEVDGEQTAHKILKGQKRRLLATEAETHGTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSW3</accession>
    <name>A0A0R3WSW3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3838</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003131">
        <property type="protein sequence ID" value="VDM23521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSW3"/>
    <dbReference type="STRING" id="6205.A0A0R3WSW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000385301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000385301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000385301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839451at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052269">
        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22973:SF12">
        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13897">
        <property type="entry name" value="GOLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000385301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17636" checksum="54959208459BE05A" modified="2016-01-20" version="1">MLRVPTHEEGSSIFWEFATDSYDLGFGLFFEWNLAPQENITITISESSDEEEEEEEEEEDGDGSAVEPASKPRNTTTTPDEADVESGGGNSRSKKLANTPPTDELIPVYRRDCHMEVYCGSHQYPGCGVYIFKFDNSFSLWRSKWLYYRIFYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUP6</accession>
    <name>A0A0R3WUP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4471</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004527">
        <property type="protein sequence ID" value="VDM25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUP6"/>
    <dbReference type="STRING" id="6205.A0A0R3WUP6"/>
    <dbReference type="WBParaSite" id="TTAC_0000448601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000448601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000448601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000448601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9929" checksum="3C188CE714945A69" modified="2016-01-20" version="1">MLDLFGFCDLLVQRTVERLGLRLDSTVASDSAGIEGADRLATFGHAMSFEPMTSMLRNFASSFRGESAVFLLKLLIVTLNWCFSMKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUW7</accession>
    <name>A0A0R3WUW7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoplasmin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4543</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004717">
        <property type="protein sequence ID" value="VDM25149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUW7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUW7"/>
    <dbReference type="WBParaSite" id="TTAC_0000455701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000455701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000455701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000455701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13892" checksum="40883174F952959C" modified="2016-01-20" version="1">MAAGARQQVCHHQEEQKVFAQIGIPVFLTCASDESRPPALLEINFNDEKIALSSRNWTTCKETEESKWQSVRLILRLLIKYEFIVPLSVKCEVKNGEDFTESGPLRKPFEAIASGAIHLHGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUZ6</accession>
    <name>A0A0R3WUZ6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucose-6-phosphate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4570</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01004786">
        <property type="protein sequence ID" value="VDM25209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUZ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WUZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000458601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000458601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000458601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM25209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000458601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17877" checksum="DFEEBA99C637B282" modified="2016-01-20" version="1">MIFSPLWNREHISNVTISFKEPFGTSGRGGYFDDFGVIRDVLQNHLIQVLALLAMEKPLSLSAEDIRGEKVKVLRCIRPLKLSNLVVGQYVRNPDAEDEEGKQGYLDDPTVSKDSITPTYACAVLYISNDRWQGVPFILRAGKGKHCVYTISFLMILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUZ8</accession>
    <name>A0A0R3WUZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4575</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004798">
        <property type="protein sequence ID" value="VDM25219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUZ8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000458801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000458801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000458801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000458801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40513" checksum="D2B7B3659203297E" modified="2016-01-20" version="1">MEKANHNLGKEEEEEEEEEEEGEEEQQGSEKGEAKGHDTNLVEKEKSSTPVVGEMQSSLQSNAATQRCRLTSSSFMAPGISRDSPSWMQETTDCLLLEFMTYMTRQMHFTVILSTLDSEAPKLDHPYALLQRSVKMAGIHLVEIFIHDCIFCVRLKAIELCRLTRAASRAVLTGPLAADVVGRAAAVAAVKIASAMIDPFSIPSGGSGSNVATANAAVSVSSSSSIPSSPYVVKWEESSRLCDCVHLHSFLYDFYLRNVDTFLRLQSDLIGQRLQVPSLTWALPQVLKAQRRGGGGSFGASRHPFLPANYPVVSFLRDLARIIPLAPVFARGTFIRLPMCLPVDTRIKPEQVFEHLIEARQAYGLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV13</accession>
    <name>A0A0R3WV13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004829">
        <property type="protein sequence ID" value="VDM25236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV13"/>
    <dbReference type="STRING" id="6205.A0A0R3WV13"/>
    <dbReference type="WBParaSite" id="TTAC_0000460301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000460301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000460301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000460301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12188" checksum="22A4926B426D800C" modified="2016-01-20" version="1">MSLRRPPLVIASVIPLSRDPLMQSGIPKCPNGTSSGGVGKQRSAPETPGALLNSLFRHTNNAARSGSLAQEEILANASLPVAKPLSHIKPVDSVVGDLVCFLLRVSYVTVFQSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVK0</accession>
    <name>A0A0R3WVK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4775</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005302">
        <property type="protein sequence ID" value="VDM25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVK0"/>
    <dbReference type="STRING" id="6205.A0A0R3WVK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000479001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000479001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000479001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133068" evidence="5">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000479001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14201" checksum="BF30EC9FCFCC517B" modified="2016-01-20" version="1">MLSGETLGLFLTLLTEVHGLFNTSEFRLASQEMVGIMDGIDEGFFAWISLLFLSQKSCLVPCHPQLPFTEASIHQQAIFDLGGGSFQLTFGVTTAAGPSEFVHNLPSAYLGTQFSPLSGKVFILIFNCSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVP6</accession>
    <name>A0A0R3WVP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4822</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005429">
        <property type="protein sequence ID" value="VDM25718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVP6"/>
    <dbReference type="STRING" id="6205.A0A0R3WVP6"/>
    <dbReference type="WBParaSite" id="TTAC_0000483601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000483601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000483601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000483601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10297" checksum="6AB3B09F981D1E1F" modified="2016-01-20" version="1">MWLLVHVFAGRVARAGRSGMAISLVDSEELPYLMDLFVFLGREVITCHVATSAQQTNFSDWPNELLGSCPRDLIAFGLESAKKRERENASLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWT5</accession>
    <name>A0A0R3WWT5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-AMP-activated protein kinase subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5211</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006617">
        <property type="protein sequence ID" value="VDM26479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWT5"/>
    <dbReference type="STRING" id="6205.A0A0R3WWT5"/>
    <dbReference type="WBParaSite" id="TTAC_0000522501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000522501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000522501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="5">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM26479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000522501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14780" checksum="D37EBE83C1DF60C2" modified="2016-01-20" version="1">MGNTPGTSKRRSSIEEEYTGSVGVMSNPYYPPKRKFILQASQAVNDDDPVVSILTEGHTIEAIANQLRNSRIQDTPERPCVFMDVVGSPESSGDTTDEAPSHTTLPTVFKWEGGGKEVYISGTFNGWKSKIPMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWZ5</accession>
    <name>A0A0R3WWZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5272</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006817">
        <property type="protein sequence ID" value="VDM26599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WWZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000528501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000528501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000528501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000528501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6324" checksum="C8B1B0DF555475E3" modified="2016-01-20" version="1">MYIVPLTILFATYIPITVKLWSDRGLGEVTRAQIEGIKSKRRVPISSSNVCECDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX24</accession>
    <name>A0A0R3WX24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BURP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006943">
        <property type="protein sequence ID" value="VDM26651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX24"/>
    <dbReference type="WBParaSite" id="TTAC_0000531401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000531401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000531401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000531401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15485" checksum="3A8D9521AF8DE8C3" modified="2016-01-20" version="1">MEVGSNYSTIFTKNTFQFSILSHMTAEGVVFPRIPVKQHTVLYSFHIPKVMESAVRLAVKAAQCQAVLRACLTNHLSHCLATMAFLICLPPRGSHLKELPTPQGRHCRASIQVLYSHHAYPYPMLHTCHNSNYYTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX57</accession>
    <name>A0A0R3WX57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CTNNB1_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5333</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007083">
        <property type="protein sequence ID" value="VDM26726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX57"/>
    <dbReference type="STRING" id="6205.A0A0R3WX57"/>
    <dbReference type="WBParaSite" id="TTAC_0000534701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000534701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000534701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000534701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9408" checksum="0A459A224BB3C15F" modified="2016-01-20" version="1">MSPCNSPEHNSPDWGPGVMDDGDYLVEGEPFEVVEAPSDQETASDPEGEMQETTPISDNSKLVLKKHKGMLRSLYFIVFFTWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX73</accession>
    <name>A0A0R3WX73_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MCM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5349</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007135">
        <property type="protein sequence ID" value="VDM26768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX73"/>
    <dbReference type="STRING" id="6205.A0A0R3WX73"/>
    <dbReference type="WBParaSite" id="TTAC_0000536301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000536301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000536301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000536301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15350" checksum="6955E3F3C207AB4C" modified="2016-01-20" version="1">MCSQTRSSTLNLANRPNLLLLLIQLPHTLLSRFDLIFLILDPQDEIYDARLARHLVGLYYKGTNNDRSRRGGIVTTSVDLDDEDPIYHGDSAAMLRDYIAYAKAMYHPKLSEEASEYLVREYVEMRKIGSSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXK3</accession>
    <name>A0A0R3WXK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5477</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Vang family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007680">
        <property type="protein sequence ID" value="VDM27066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXK3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000549301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000549301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000549301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8887313at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20886">
        <property type="entry name" value="VANG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06638">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM27066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000549301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21013" checksum="F5F8A581833FEA6C" modified="2016-01-20" version="1">MFLGNGRAVGAGVGGTKALDPYEAAQTVFPTLIRPLQKYLRATRQQSRHPVDSVIDHLATCITFGLSPLTFLERFNPAASTPQQDAATAANALTVARNIAQRHRRPLTIAGGAMAGSGGGTEGGVEGAEYKPPGPPVAPGGQQLWQIVADRALSRDLADGLVFQLRRQHGNCEISLLCTVHRLPLLQLLEVGAGTSGAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXZ0</accession>
    <name>A0A0R3WXZ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008234">
        <property type="protein sequence ID" value="VDM27328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXZ0"/>
    <dbReference type="STRING" id="6205.A0A0R3WXZ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000563001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000563001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000563001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000563001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9835" checksum="656C584677A5D969" modified="2016-01-20" version="1">MESDMHPFMLAMGPDIPHFTDRKHFYQVDLYPYICAMLGLDKPNRIDGQIDRVLPYLKNKPSREYVDQFRLYASGTLPHQDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYK3</accession>
    <name>A0A0R3WYK3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5827</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009258">
        <property type="protein sequence ID" value="VDM27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYK3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYK3"/>
    <dbReference type="WBParaSite" id="TTAC_0000584301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000584301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000584301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000584301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26158" checksum="8490D309AEC32B4C" modified="2016-01-20" version="1">MRQYVAQNDTLGLIELTRQSLDNKAKAIFCQLLKCHLASMWNFKDMVIAANGEHKASSALKEAANVIASSPLALQLRYLQTLCAISAEKNSTIIFPLPIDILHSSAATVNAKLGSSTISLNEGDSQSRRRKAMVRQWLPSLSPDHSVTPNPRALLPGMGEPDPLIPQPVPPQLPESQRRRYEAAALLTVTGAAKKATVTTASPLPPAAAVETSARDSQPPPQLPRPQLGVAHEDFDDTCSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYT0</accession>
    <name>A0A0R3WYT0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009642">
        <property type="protein sequence ID" value="VDM27937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYT0"/>
    <dbReference type="STRING" id="6205.A0A0R3WYT0"/>
    <dbReference type="WBParaSite" id="TTAC_0000592001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000592001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000592001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10454049at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000592001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21669" checksum="7AD9570F97CB576F" modified="2016-01-20" version="1">MKKNSANMGDGKLVDRKSTASCPSQRYTYVKKVDLGKKYPDSSDKEDQKDGSVSLLQSSEMEPRFPRMMGTSDTGGPLFYFQKDLKVADNDFDEELRTAAVPGEEGEQEPDFDASYFSRGDTPSPAPSVSVPSSSFVFSGFSKWADGIEREDEQIRGGRRAVCRNRSSRSKFTHGAYAQTISQDGRADSALLRTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ11</accession>
    <name>A0A0R3WZ11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep_M12B_propep domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010075">
        <property type="protein sequence ID" value="VDM28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ11"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ11"/>
    <dbReference type="WBParaSite" id="TTAC_0000600101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000600101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000600101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000600101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19379" checksum="88CEA6B9ADE2921A" modified="2016-01-20" version="1">KLEDCFYTGEVESAPNTSFVAVDTCSGLRGAIYYQNTTFVILPLPCPSCDPQTAPHIVLRWSSSAIAQNASMHTFWKPVDLMAMMQATVDQRLGDLSSVVHIIWLEFIVDEKLIRLATLYVERNRSTFEMYLQVVQTRQGSCEAFLKRFSYADLLSTTNKKATMDAPTSNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZI1</accession>
    <name>A0A0R3WZI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZI1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000620401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000620401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000620401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020110at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040126">
        <property type="entry name" value="STOX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437:SF0">
        <property type="entry name" value="FI21431P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437">
        <property type="entry name" value="WINGED HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000620401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14797" checksum="D544027DF40B3782" modified="2016-01-20" version="1">MNLGILSSTRCLAIAFQQEFALAVRTFNIYDVFKSFLNVNVANTTNPYLSQALKKCLLLGHIEPFVILIGGDEVSLRTLKCCWMRAQLQPPPGFRIESIGPFLSVAMGTWILSVLRQEFDTCGGNFRVPIGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZI6</accession>
    <name>A0A0R3WZI6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS6194</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZI6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZI6"/>
    <dbReference type="WBParaSite" id="TTAC_0000620901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000620901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000620901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000620901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="19027" checksum="7B358DAD3ED2044B" modified="2016-01-20" version="1">MAKPVPPAYLRTKLVPHAQKVCDLYKAALYNIKAQKLDQFEAVLLRARFDRNKDVKDPVKAKKLLEDGWKELQKNKAAFPFLCNFDLDPTSPGGVAYERYDFHRPDYLLDFWHPLEKLQYPDYFALREKRKAEFIERWKARYGEPKALGCEIGEDPTTEVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZP9</accession>
    <name>A0A0R3WZP9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DnaJ homolog subfamily B member 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Testis and spermatogenesis cell-related protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Testis spermatocyte apoptosis-related gene 6 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Testis spermatogenesis apoptosis-related gene 3 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Testis spermatogenesis apoptosis-related gene 6 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS6271</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Interacts with SUN5. Interacts with IQUB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZP9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZP9"/>
    <dbReference type="WBParaSite" id="TTAC_0000628601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000628601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000628601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000033">
        <property type="entry name" value="dnaJ homolog subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="19">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="543"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075378"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078669"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00080190"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00081125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM30456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000628601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113376" checksum="48978DE5B89ACBC9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZS0</accession>
    <name>A0A0R3WZS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF572-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6296</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZS0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZS0"/>
    <dbReference type="WBParaSite" id="TTAC_0000631101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000631101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000631101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
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        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000631101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41806" checksum="4C62538C8C4A5FB2" modified="2016-01-20" version="1">MVVDAIHGERKGTNKYYPPDFDPAKHRSLNAYHGVHALRERGRKADKGIIIIRFEMPYNAWCLSCKKPIGMGVRYNAEKKKVGMYHSTPIFQFSMNCAMCAGRIVMQTDPQNFDYVCVEGIRRKIQTWDPEENEQIVVPDFKERQKLSLDAMYQVEHSVKDKEKAALSNPALAELEADRGSFKDDFALNCLARKQFREAKRLQNDADARDETLRTRLSLTGAQINILDETDEDRTKAKLLRLHRTRGSYCHHYPPLDRSERTSERQLSLVKIGKLLLSKRKLENSCDIPLTQRRVERHYLVKRSGILGISAKQSRTSSLPHETLPQAPHKSTRKVTNQVDEVSSKELTTNEEPIPSLVPYNDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X013</accession>
    <name>A0A0R3X013_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">LIM/homeobox protein Lhx9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS6416</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020302">
        <property type="protein sequence ID" value="VDM30622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X013"/>
    <dbReference type="STRING" id="6205.A0A0R3X013"/>
    <dbReference type="WBParaSite" id="TTAC_0000643101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000643101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000643101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM30622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000643101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38465" checksum="5A505D9E07704628" modified="2016-01-20" version="1">MGDPVVSPYEAIYESPDQPMSIVCANCGKPIVERHYLLADGQFWHATCLRCALCGCDLQWQTSCYHHKGRLLCWQDYANCATCPTCDRRFHEGDLVISFQMGLSFHVECLRCRVCEKTFQIGDRCFVEGDGRHGVSCLNCRQQRSRKARNRPPFFQMTPNLSTSSGNMIITASSSSTEGEGHEMQCKSSSVDQINNHFYRSTVTGEEMQGKARCQSISSVSLASDNPQKRIRTSFKHDQLRLMKAYFRVNQNPDSKELRQLSAQTNLSKRVLQVWFQNARAKYRRWTSNLENKAGDVQTQESVDRPLTADASEDATTVEEPTRPCDFDLPFDHDKDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0F3</accession>
    <name>A0A0R3X0F3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger CCCH domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6594</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020310">
        <property type="protein sequence ID" value="VDM30826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0F3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0F3"/>
    <dbReference type="WBParaSite" id="TTAC_0000660901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000660901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000660901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1350">
        <property type="entry name" value="Pneumovirus matrix protein 2 (M2), zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054361">
        <property type="entry name" value="Znf-CCCH_ZC3H4/6/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22623">
        <property type="entry name" value="zf-CCCH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000660901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="570" mass="63663" checksum="E55683793CA446CE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Q3</accession>
    <name>A0A0R3X0Q3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6715</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020317">
        <property type="protein sequence ID" value="VDM30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0Q3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0Q3"/>
    <dbReference type="WBParaSite" id="TTAC_0000673001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000673001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000673001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="853"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000673001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135189" checksum="85A03DFFCB0AD278" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X169</accession>
    <name>A0A0R3X169_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6907</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X169"/>
    <dbReference type="WBParaSite" id="TTAC_0000692201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000692201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000692201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251630at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000692201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55937" checksum="08B4EFBC41D2B46F" modified="2016-01-20" version="1">MSTNYKMDKVLVVRFRLFTGSGSIPDDILRSESKDFLLKKLFLGNYTKQQLNLFYTVEKPGRAPQRITSTKTRFISPRVYVYMDQLILRQARKKDTGIYTCMYRGRPRVTWAVTVLGAGEEPYRQTIAPMVYLKNNETDPKVSKSIRTLRRKTIIPANVEIFTSWGPWSPCVPCVAQLPPGIPELGFFERGGEGFQMRVGTCYVRMLDTFFPLRPYKLARYATKPLRQFGRSGLPCRSHLIARGVLESGIRALKKRPSELIIRPCYRPCSAPKNSLLYSFIPFTRGMEKMSALEAANEVSKPSIKRMRVKDGDSFVLSCPVRGTVHSPISWFRLPTSKSETSNLTATALMAGAFGAFGTPSGWLAFHAEQVNLSTLLMKSRGRVRLDPAYHLIYAEAKSAIDAAVDKGSGYLPVFRLACVHGDARGSNFKWSDWSGILTVETIVRWSQLEVITGLSTAVAVLMPAFLSLATVCMAVKCLVDERRAGMRAAAAGRARRPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1G1</accession>
    <name>A0A0R3X1G1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MADS-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7023</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020339">
        <property type="protein sequence ID" value="VDM31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1G1"/>
    <dbReference type="STRING" id="6205.A0A0R3X1G1"/>
    <dbReference type="WBParaSite" id="TTAC_0000703801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000703801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000703801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="285"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000703801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="761" mass="84171" checksum="412E7C2B3C65901B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1I1</accession>
    <name>A0A0R3X1I1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020341">
        <property type="protein sequence ID" value="VDM31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1I1"/>
    <dbReference type="WBParaSite" id="TTAC_0000706501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000706501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000706501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000706501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10941" checksum="F27D485F40CF68BE" modified="2016-01-20" version="1">MIEEVDKTAASRGDGTRPAVTETSLESPQPVGTSHDPKHNMMEVVTTPPGAAPLERLIRLQIAMLIYVLTCLSVASEDDEIQFGPGIEAALGKTAKIVSINVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2D2</accession>
    <name>A0A0R3X2D2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7426</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020372">
        <property type="protein sequence ID" value="VDM31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2D2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2D2"/>
    <dbReference type="WBParaSite" id="TTAC_0000744101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000744101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000744101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000744101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33400" checksum="EB256D7C62AA9BD4" modified="2016-01-20" version="1">MKKLDVAELYPPFPYISVPDFHTVKIDWYECLEELEEQGMNVAMEQIAQIFVIVPFLLLLFSNAKIEFTDQMDYTPLMAAVSRNNKVIIRILLSYGANVNTANKLGRTALMLASNKGYIDIVDILIKKGANVNARDIHGMTALFYAVDGEFSNVVRALVRAGADVNHCESDNGYTPLIRLACLANNGNPKVGDTLIECGAKVNQQDKFGQTALIHCAFHRNHADLAKVLLQHGADLSIRNNVKEKKNTAADIAKSLDNTVSLICIGLFIYLMFGFLEFSPSCKFAQEKRVNFDCWFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2L3</accession>
    <name>A0A0R3X2L3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020379">
        <property type="protein sequence ID" value="VDM31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2L3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2L3"/>
    <dbReference type="WBParaSite" id="TTAC_0000753501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000753501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000753501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="441"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000753501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="581" mass="65125" checksum="A9F5CD61608B7D8B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X389</accession>
    <name>A0A0R3X389_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS7783</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="EMBL" id="UYWX01020404">
        <property type="protein sequence ID" value="VDM32240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X389"/>
    <dbReference type="STRING" id="6205.A0A0R3X389"/>
    <dbReference type="WBParaSite" id="TTAC_0000779801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000779801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000779801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5974730at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM32240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000779801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="598" mass="68365" checksum="A550B3547230653E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3L1</accession>
    <name>A0A0R3X3L1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7928</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020422">
        <property type="protein sequence ID" value="VDM32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3L1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3L1"/>
    <dbReference type="WBParaSite" id="TTAC_0000794301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000794301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000794301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000794301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21988" checksum="EA996E64D21375B6" modified="2016-01-20" version="1">MPSAHLESLAFAKIILHVSKYPHAAVNGVLLGDIVGGMLVIHDCIPLFHGFLTLTPMLEVALTQIEAYCDSLNWKICGYYQANEALNSNELNPVATRIGDKIFENCGQGNIIIVRNDRLRALSSETFSLYCRRDGNWHESSRPSVEQSAAEFVKPFLDETIIEGFADFDNHLDNVRMDWRNMDFFHENEIDKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X403</accession>
    <name>A0A0R3X403_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8094</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020447">
        <property type="protein sequence ID" value="VDM32592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X403"/>
    <dbReference type="STRING" id="6205.A0A0R3X403"/>
    <dbReference type="WBParaSite" id="TTAC_0000810901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000810901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000810901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000021">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="5">
        <location>
            <begin position="138"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000810901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="47414" checksum="38837267BC91BBA8" modified="2016-01-20" version="1">MPCWYYEKEDFLRTPSVLDGVDQQTENRYRREGARFILDLSTRLHLRYDTWATAIVFFHRFYMCHSFKAFPRHVTAACCLMLAGKVEETPKKCRDIIRTARELLSPELFATFGNDPREEVMMYERVLLKTIKFDLQVTHPYSFLLQYAKRLKGSQEKIKEIVQMAWSFINDSLETTLCLQWEPEIVACAVLYLATRMKSWPVTDWHGRRSGQPWWECFVEGMTVEVMEDICHRILDIYSDGNKPSSTETVAKSDPPPQTGSKRRSHCAPSPPPPPPPPPPPPPQPLKKPLEAIPLQSSNNNATMATTTTSGLVWNQTVPRYGHGILPTAFPQPFVGVGSASTTIVGAPPPPPPPAIPLAPPLPPPPPPLPTVLAGQAPPPPPPPPPPGGPWLPPPLMSVVVPPPSAAAAAAAAAFVATPSSFPPHAPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4Q9</accession>
    <name>A0A0R3X4Q9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8395</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020497">
        <property type="protein sequence ID" value="VDM32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4Q9"/>
    <dbReference type="STRING" id="6205.A0A0R3X4Q9"/>
    <dbReference type="WBParaSite" id="TTAC_0000841001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000841001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000841001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000841001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37492" checksum="02528B127B96E9AA" modified="2016-01-20" version="1">MNNFPIDTLSDVSESDSCSETPHVDSSPTLQVTSALPEVQPLQPQSKRSLKRRRKKWVPFPKSQFRFKGHEEIMRDPEILRWWKRRFDLFERFDEGIQMDRESWYSVTPEEIARNQADTCACDLIVDAYAGAGGNSIQFARTCGFVIGIDNCLDRLIGVFTPNTRVYGVSSCIDCICGDVTRILRALRADTCVDTIFMSPPWGGPSYPHHRPLPPGSASWNKRRRRQRIIAEMRAAKGDDIYDLTANIPSLMEAIVAARSLFPTRPRIAVYLPRNCALGQVLKLGWGGENLESAEGREEVVIEEYWLRGRRLAICAYIGGFAIEDSLTRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U7</accession>
    <name>A0A0R3X5U7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTPRF interacting protein alpha 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8846</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020606">
        <property type="protein sequence ID" value="VDM33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5U7"/>
    <dbReference type="WBParaSite" id="TTAC_0000886101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000886101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000886101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Liprin-alpha CC2" evidence="3">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Liprin-alpha CC2" evidence="3">
        <location>
            <begin position="314"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000886101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52884" checksum="47D8292F242A15C7" modified="2016-06-08" version="2">MCDIMPTIAEDGNSSQGDRDSQVSAEGNTVEDMLLSILDERDRLMENFQEAQEQLSYSQNRLSELEREKDCLSRQLREKVPEVCGFLNPIVGYLFALCYQLLEREDEIQELKAERSNTRLLLEHLECLVARHERSLRMTVVKRQMSSPGGVSSEVEVLKALKSLFEHHKAMDTRLRERLRAALERAAQLEEDVRASASDRASLREQLAAALANIAASTGVILSTAASTLSIAFCLSFPHTKVTRLQRDLRESEAQREDQESRISTLEQRYLAAQHDATAAHEKANPDPSAAVSVPSTIEISELQESNIRAMRAELTQADDRLREVQAAMAETQAELQRARQRERLNEDHSARLTATVDKLLLESNERLQTHLREKMAVMEEKNQLTAELDRVRRQMESIQSERDRLVNELDRLRRQASLAESLDLPNLNRWQGGFILLMTVAESQPYSYPFHQHGGISCHTVGFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5W1</accession>
    <name>A0A0R3X5W1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8861</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020610">
        <property type="protein sequence ID" value="VDM33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5W1"/>
    <dbReference type="WBParaSite" id="TTAC_0000887601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000887601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000887601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000887601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12011" checksum="369A0E1D13707756" modified="2016-01-20" version="1">MGRKYSHWAATLTLRYEDHPPLLVLVLFYLLPPSSFSSSSSALSRSRATKKASFRFALPVPRQVSFGDPHSGHNTLGMDFLSPKARERGCVSQLVAVGPANANPKVLPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6P1</accession>
    <name>A0A0R3X6P1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9169</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="UYWX01020700">
        <property type="protein sequence ID" value="VDM33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6P1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6P1"/>
    <dbReference type="WBParaSite" id="TTAC_0000918401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000918401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000918401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000918401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34931" checksum="85116B7490F6167A" modified="2016-01-20" version="1">MSDSGNWCLIESDPGVFNELMYGFGVDGLDCIEVYDTRNTDAFSDALGLIFLFKWDGNGWDASKSLDYAESGSIFFAKQVITNACATQALINVLFNLPPNSLKLGDTLTDFKSFVSDFDSQMKGTALANCDKLRLAHNSFARPQVFEITLNKPCKPEDIYHYVGFVPISGAVYELDGLEPHPIRVASIPEGTSWLDVILPIITKKMSECVDGRFNLMALVPSRLQMYETRAAEYLTNPPEDKNLIDQNEYCIFAERARIAEQRSENNRRRHNYLPFIMELLKVLAEKNLLTDVVHRAREKSQSVQTSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X789</accession>
    <name>A0A0R3X789_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9397</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020799">
        <property type="protein sequence ID" value="VDM34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X789"/>
    <dbReference type="STRING" id="6205.A0A0R3X789"/>
    <dbReference type="WBParaSite" id="TTAC_0000941201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000941201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000941201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6154955at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF50">
        <property type="entry name" value="COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="C1q" evidence="4">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000941201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24206" checksum="13FA7834C37C9126" modified="2016-01-20" version="1">MTLSIVEANDLVFQVDKSSSPACYFQLECTGKTAQGVEKVRVPIRSAQGPPGPKGDRGPRGLQGLMGPPGPPGPPAKAPPLVPQASRPPQIAFYIGLSQNIDQVPPGENCPLIFDTVILNVGGFYNASNGVFITKISGVYSFLLVVSARSYEKASAWLMLNGQKVLSAWCESKPWASTTNQAILQLKRGDKLWLQCSKEAYHLHGYLYSSLSGHMLFPTTDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7M3</accession>
    <name>A0A0R3X7M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9533</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020873">
        <property type="protein sequence ID" value="VDM34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7M3"/>
    <dbReference type="STRING" id="6205.A0A0R3X7M3"/>
    <dbReference type="WBParaSite" id="TTAC_0000954801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000954801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000954801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="335"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000954801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="858" mass="95847" checksum="C4B19D94917F12A6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7P6</accession>
    <name>A0A0R3X7P6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0160 protein MYG1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020888">
        <property type="protein sequence ID" value="VDM34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7P6"/>
    <dbReference type="STRING" id="6205.A0A0R3X7P6"/>
    <dbReference type="WBParaSite" id="TTAC_0000957101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000957101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000957101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000957101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38541" checksum="8DB6933D37318B8F" modified="2016-01-20" version="1">MKLGTHNGVFHCDELLALAMLRQLPEYHNAQLIRSRDPDVLRDCDVVFDVGAEYDPDRHRYDHHQSSFNKTIQDFYPNLKPAVKLSSAGLIYAHFGTRVISSILELKSTDSEVVKAIYPFLYCSFVSEVDALDNGVSMAPVPLTYSINTGLSSRVDRLNPPWNKVDEDEMKCFDQAYKLVESELVSTVRDLAETWYPARTIVKDAMLSRYSVHPSGAILYLSQGCPWKSHFFELEKEMLGVADCDVDRVTDFKGRPVFVIVQRKGAGEIQFSLICIPWQPNLPFSNRVPLVSAWGGKRDEELSQLVGLPGCVFVHATLFLGIHKTFDGALQMAVMSLKAAGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8D4</accession>
    <name>A0A0R3X8D4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9794</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="VDM34720.1"/>
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    </dbReference>
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        <location>
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            <end position="811"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000980901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="923" mass="99194" checksum="7136FDBE31DB4520" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8S9</accession>
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            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000995401"/>
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    </feature>
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        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM34919.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000995401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10212" checksum="B51EEC7D322FCF71" modified="2016-01-20" version="1">MRRLHDDVTPKILTGHSKEQLICLDRLNSPDTSHDTECFSMSTTPNPPSQESDSIDDVSEEDRNVAVDEEGEVQVDDSDDALEESRPLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8V6</accession>
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        <submittedName>
            <fullName evidence="3">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TTAC_LOCUS9966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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        </citation>
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    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000998101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="51749" checksum="2833BAF268879573" modified="2016-01-20" version="1">MTCVSYTINPMVASITIPKESTKAGSANATVSSDQRNRQSVLRRGCVSTPQKESPAMKAVACSSSLPINYPRNNQASPSLFNYQNLNVYVVGNVGHPKAQIVRVVHISDTRGVGDYYAKGLPNGHILIHSGDFLDGPPLRHRTPLRRGYFRKSRTEGKFSPSTSASSFSSPSTEECVWKAKLQSINEFFRHQPHPYKIFVSGCWDYLGPERPSAAQIQKCLPSAIYLEDAACEILGLKVYGIPWTSADDLRPEDGKSHFTSSIGTSNVKTILPQWLLRSSMSWSRSRRQTRRQRCLSSCTGASETSTTAAQARTREMVVIRGRSNVWPAYHSPDASNGSCSSSTNAKAGACESGSSSSSSSCSSSASSLSSASASALCDGFILPDIKAVEERYARVPSDTNIIVSHMPAWRPELYTHVVDRIHWCVGMSACASVNHFLVFLRHFPSSSLTTAMTNRAPAGCLYNSQGGVPLLIAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Q0</accession>
    <name>A0A0R3X9Q0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10260</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="TTAC_0001027501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001027501"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
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            <end position="99"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001027501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12619" checksum="AC6C72E1B203B9B8" modified="2016-01-20" version="1">MYCCRIDLSKAICNVEEKIAPQQLSLKERLFCSASAQGPSRRERTIYTPDQLEAMEELFRENKYPDVGMREDLAARLRLSESRIQVWFKNRRAKLRNMERHRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA41</accession>
    <name>A0A0R3XA41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FRG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021657">
        <property type="protein sequence ID" value="VDM35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA41"/>
    <dbReference type="STRING" id="6205.A0A0R3XA41"/>
    <dbReference type="WBParaSite" id="TTAC_0001041801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001041801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001041801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2096280at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001041801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28601" checksum="5A5A701BC337070E" modified="2016-01-20" version="1">MNKRNVAELMFGYAPRNILGLTNPHSAPFHDNRGIGNQCIDLNEQARIVGALVKKQLRDKRYNRGPDLAATLCYLANGEQYITEAAAQMIYEAFEPPLDEELRELLFDVIRNDNTRSSESVGFREADTNDSKIINWRLMAKMLDHNRLQFWEGPFKHDGIEDTPCIEKILEETGLSGGCNVEKIWTIAKQFDGKKMVMGTATYDDERVTLEGVRQALNQYNCQQIEAKVAEKYKSCYITMPEENNEELLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA63</accession>
    <name>A0A0R3XA63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10423</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021679">
        <property type="protein sequence ID" value="VDM35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA63"/>
    <dbReference type="STRING" id="6205.A0A0R3XA63"/>
    <dbReference type="WBParaSite" id="TTAC_0001044001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001044001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001044001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="5">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001044001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24022" checksum="62D3397F697243D4" modified="2016-01-20" version="1">MSEFVCEQFVRRYLMSHNYFRTLAAFDGESHSDNLNYCFQPSKIIETVSRAITGLDCEALENIWKGLGDCFSSRLDRRNSAKFESLKAYTFKTLLCEAVKAKQLTCINIFFSGQKIFDLSSSAWIHWSALPFIKEPTKHFLFGRYFTKTWLDVLLMSLSNFLCTLFLSLSDPVKNAPIQIANHANLPRMNTEMLDDFADLPAARVAKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAH9</accession>
    <name>A0A0R3XAH9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5731 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10539</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021826">
        <property type="protein sequence ID" value="VDM35519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAH9"/>
    <dbReference type="WBParaSite" id="TTAC_0001055601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001055601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001055601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6238511at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043789">
        <property type="entry name" value="DUF5731"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19002">
        <property type="entry name" value="DUF5731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5731" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001055601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17204" checksum="259A4D6C95CBA519" modified="2016-01-20" version="1">MYDYQFQAHFCEPVYEAHHLHCTKQDGEVAFTMRQIGTWLTLSSVFCRCSQPAEVTSISYTHGIKPTDIAFRGVFYEMTCAPSRECRTDESCFIETPSSDGLLYGGKVMCMCPKKTFCPIYFIGKKRVPFKDSQQRITHYGLKCKQRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAI1</accession>
    <name>A0A0R3XAI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS10541</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021829">
        <property type="protein sequence ID" value="VDM35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAI1"/>
    <dbReference type="STRING" id="6205.A0A0R3XAI1"/>
    <dbReference type="WBParaSite" id="TTAC_0001055801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001055801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001055801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF10">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001055801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="486" mass="53998" checksum="95E3983D033AC96D" modified="2016-01-20" version="1">MPRDSGFSALQVDDTRLRMHEILSSAISDHIQSVVEFAKAIPGFVSLDQPDQLTLLKAAFPEVWILQAARTISYPEQTILLCNGAIVCRKELDFIYSSTLMCAIFEFAAEFNALNLSDIEIGLYSAILLTKSNRNGLSDTAKVAAIHERFLAALSYQLEEKHGSVSDIMNGLKVATGRLAQISESLHFVMSWFRSLWYRTHLPPLYSEIFDIAQGDSSARVPQAQPYMPIDFQSLTCASAQAPVGYNTGTTSYMAAKAPQTLFHYHQYQNFPASQDYFAMYNAQGNTYPNMTDYTDESNQQQFIYTSGHERWHSSAFEPYSTDMQSTVRTYSHETQRVDSDVVGDHSRDENASTSTYTESHVRSRSHSSTTSPGSITSVADSTIVSGDDPFTAYQSVDVPALSRANSNVADIEAEGIHPNWENLSELNGLEKDANGLKPEMPTLIPAPEIMAAIERRKDISTPLESMTDEGIEHEEMLPVENRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAJ1</accession>
    <name>A0A0R3XAJ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021848">
        <property type="protein sequence ID" value="VDM35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAJ1"/>
    <dbReference type="WBParaSite" id="TTAC_0001056801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001056801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001056801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001056801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20354" checksum="BE2BFAFD1043EB60" modified="2016-01-20" version="1">MQKKLVFLGLYSLSDNESDPESCVSKEWGEVVDVEQTRELPTMQQSIKEDIQLSGPGFPSSTNFQAFNPTANFQRPLQASSMITASTNFLNRIPSLSRLHPLKLRPTPNAKSRSLGSKEIVHDSGNSRKALLAARPGSRAYDPESNSTSASIRSHALKKNPITRPPSSPRAGLTKRVSLPVSRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB21</accession>
    <name>A0A0R3XB21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022145">
        <property type="protein sequence ID" value="VDM35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB21"/>
    <dbReference type="WBParaSite" id="TTAC_0001074801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001074801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001074801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6241467at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001074801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30295" checksum="8DA2425825CEC112" modified="2016-01-20" version="1">MFHTNGAGGLLLGRHVLAPRHDHGNRLYLGVVKTQKKSKRFGVVFCIPYAGLKEDESLEYCMQEVDIDDILSYTDLYRHAVCEKDDVLVPASLLQPRNGEGARSEALMDPPFAGQPYVLAVVHKGFEPRSSRGGRVGSPSRKTASLVVKVTGVEQPRLCAIPAGCALWIPEKQARVLYSQQCHFYDQKASDRRDVSPFHEEHESLCMHGGPNSPSHRTNNGDTNSQHSYKSSELFRRSVDSAESVSSSFSSLHAHRRGRSSGGRSRTGNLHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB45</accession>
    <name>A0A0R3XB45_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS10756</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022194">
        <property type="protein sequence ID" value="VDM35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB45"/>
    <dbReference type="STRING" id="6205.A0A0R3XB45"/>
    <dbReference type="WBParaSite" id="TTAC_0001077201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001077201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001077201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000081">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="14">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001077201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30273" checksum="D4499A15CB507C6D" modified="2016-01-20" version="1">MQQIRKDKNFPIWLPIIRANQYPNTLLGSSEREYFFDDENEEYYFDRDPAIFRYIVDFYRHGFLHFPKSDCFLAYENEMEFFRISTECMGECCYEHFQDCRREHSERLREGRSLDDLRCAGPTTFRQRLWTSFENPGNSTVSLVIYYVTGFFIAVSVLANIIETIPYPEVSPDLSRKSIGDVFSDAFFCLDSACVLIFTVEYLARLYSAPNRWLFFRSVMSLIDVVAILPFYIALLLPNKKLHGNTDLAVITSVLNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB74</accession>
    <name>A0A0R3XB74_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IRF-2BP1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10784</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022239">
        <property type="protein sequence ID" value="VDM35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB74"/>
    <dbReference type="STRING" id="6205.A0A0R3XB74"/>
    <dbReference type="WBParaSite" id="TTAC_0001080101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001080101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001080101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="6">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001080101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37148" checksum="BA614952EC4B5EC5" modified="2016-01-20" version="1">CELPRSPWALVFDFSVPVCRGCVNYEGADRIEQVIQWVGAQKHTILQSKERSKGMKIQPFLSNHHSTIIAHYMEALRFLQQHQITNNYQQRQQQQRNHRREFNFPAPVRSIGQSSLRSALCVGLSHDTSCSVRDRLFFEYPAASGEVVRGVSKLLERMDTTEAEMEIEAQQGCWCKLEEAVSYLQDEWIQAQCLTCGAALEGSHFVQCPVRSQHRFCFGCAKAAMLDAEKGNSKKEEGEEKTREKRRLFHCPSGEMCALPETPSVPWSFVESEIAVILGSAGANASCNGVAKKRHATVAPTSRQHQQQPRRQASEAKLRRTESPDTPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBF5</accession>
    <name>A0A0R3XBF5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10865</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022395">
        <property type="protein sequence ID" value="VDM35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBF5"/>
    <dbReference type="STRING" id="6205.A0A0R3XBF5"/>
    <dbReference type="WBParaSite" id="TTAC_0001088201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001088201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001088201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF2">
        <property type="entry name" value="TYROSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001088201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12907" checksum="6D9AD20171AC39DE" modified="2016-01-20" version="1">MASVEVVGDAELRSLLQDNDGKVFEVYWGTATTGKPHVAYFVPICKIADMLHAGAKVTILFADLHAYLDNMKSPWSILCHRATYYETVIKAMLESVGVRLDQLHFVRGSDYELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBK8</accession>
    <name>A0A0R3XBK8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="12">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10918</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022525">
        <property type="protein sequence ID" value="VDM35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBK8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBK8"/>
    <dbReference type="WBParaSite" id="TTAC_0001093501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001093501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001093501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001093501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13494" checksum="29AE14C9048D4D9F" modified="2016-01-20" version="1">MSSVGVPIKVLHDAEGHVITLETINGEVFRGKLIEAEDNMNVHMQEIIMTARDGKTSSLQHVYIRGSKIRFLILPDMLKNSPMLKRPLGARGLGTGRGKNIIVRAGSRGRARPLRGAPFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBM1</accession>
    <name>A0A0R3XBM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10931</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022551">
        <property type="protein sequence ID" value="VDM35911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBM1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBM1"/>
    <dbReference type="WBParaSite" id="TTAC_0001094801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001094801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001094801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF150">
        <property type="entry name" value="SODIUM_MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001094801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10996" checksum="9CDEE6AAE5D61CD0" modified="2016-01-20" version="1">MMVQRVLAAKSLSHAQGATLMAGFIKLFPLFIIVMPGMISRILYPDTVGCGVPEECYRICGNRHGCSDLAYPRLVMGVMPNGELRIFHRALPPSLLLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCT6</accession>
    <name>A0A0R3XCT6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11346</name>
        <name evidence="2" type="ORF">TTAC_LOCUS11449</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023721">
        <property type="protein sequence ID" value="VDM36326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UYWX01024240">
        <property type="protein sequence ID" value="VDM36548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCT6"/>
    <dbReference type="WBParaSite" id="TTAC_0001136301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001136301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001136301"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001146601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001146601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001146601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001136301-mRNA-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001146601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7964" checksum="DB38BD0FB0C46F5C" modified="2016-01-20" version="1">MEKAATVNHAHHNDAHWTTPQFTPYFSILCHPILCSRAQYACRAKVGMGVAVGHHNPGVLTGQGLAFAARNAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDA3</accession>
    <name>A0A0R3XDA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11513</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024625">
        <property type="protein sequence ID" value="VDM36813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0001153001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001153001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001153001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001153001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15413" checksum="E17716DC1E0F2F5F" modified="2016-01-20" version="1">MISDSVIRRRFADSRQFRHDGVDAMRGRRGDHVIRMEVVMSQLFNRLVDREYTFAVSSLLLTSCHGIVGQSPNATALWDDGGNDFVASLASLWVHNAELFSHTPVVXXXXRLVMALLVNHQMLQRCGTTEATILELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDC1</accession>
    <name>A0A0R3XDC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11531</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024707">
        <property type="protein sequence ID" value="VDM36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDC1"/>
    <dbReference type="WBParaSite" id="TTAC_0001154801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001154801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001154801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001154801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9644" checksum="D5198B71E4E0CC90" modified="2016-01-20" version="1">MFAFRPYPLTLLPPFLSSHHPPPTALPPSLPLPPLSPPSSTHVTSHKNLPSSVLRFDLLFLHLCLCAATASTSSSPSRPQYAASCIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDA0</accession>
    <name>A0A158RDA0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PINc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS185</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000012">
        <property type="protein sequence ID" value="VDM16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDA0"/>
    <dbReference type="STRING" id="6205.A0A158RDA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000018401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000018401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000018401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920073at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF7">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="711"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000018401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="914" mass="103553" checksum="8AFBD533449842E4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE16</accession>
    <name>A0A158RE16_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6482</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE16"/>
    <dbReference type="STRING" id="6205.A0A158RE16"/>
    <dbReference type="WBParaSite" id="TTAC_0000649701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000649701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000649701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000649701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26672" checksum="0EC5D161E43452AB" modified="2016-06-08" version="1">MSQQPSAQPPPKASKANALLTSRHDASVPLRLLSTDTAHSSHTLILAIDKGELTGGVSVGKRLLPLSQHTFVPCLSLLPLSPPPTPPPPPPPNYDATSRMCWNVSSRATRGRPSPQACKGTTTAVDSKGTLVTIPKVPINILSHDQTPRLPPFLSQMRSFRFCHQYKALKSEQPATQPATQSVSSQPASQPNQSVGRSVGRSGDQPASQPAKRPTVANRFGHVISSRWLCTYSCKRILSPLAFKPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE86</accession>
    <name>A0A158RE86_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS6863</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020327">
        <property type="protein sequence ID" value="VDM31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE86"/>
    <dbReference type="WBParaSite" id="TTAC_0000687801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000687801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000687801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="18">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="17">
        <location>
            <begin position="92"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="19">
        <location>
            <begin position="414"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1087"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000687801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="175628" checksum="18C9CFB387A1A7EF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REE6</accession>
    <name>A0A158REE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7139</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020348">
        <property type="protein sequence ID" value="VDM31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REE6"/>
    <dbReference type="WBParaSite" id="TTAC_0000715401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000715401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000715401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000089">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="2321"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2153"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2239"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2293"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2440"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1237"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1633"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2165"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2309"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2440"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2450"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2472"/>
            <end position="2486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000715401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2486" mass="286046" checksum="04E19AE95CFB3796" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EM11</accession>
    <name>A0A3P7EM11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001330">
        <property type="protein sequence ID" value="VDM20766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EM11"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="308" mass="33614" checksum="4AF9A14FE438D2F4" modified="2019-02-13" version="1">MRHKAGDCGTPSQWVWQKCDGETTDTPIALQTPFMWNAHHQHQHSITITIIGIIVVVINFLVVVVVVVVVVIHHCIPYLTPLAMQTTHLQTSNPMLDPPSIVGHADTLVNANEAACRLEDHPSSGLPKSRSILASSALSTELPVNCPMLCFLLLWSVTFITYPYVTAGPAGRPLYAIWVFVLFFSLSAHFVVVPGTCTRVFGHVHMATIYGLVYFATVSALLHPLTSLSVCPFLAHTSNSTIPIPLCLPLNASAPPCVCASFHSTVSFLPPYPPCDLVRVTLSCVFLLAHGLHFEAQDPLAQIYCKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F1P5</accession>
    <name>A0A3P7F1P5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS5772</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="UYWX01008986">
        <property type="protein sequence ID" value="VDM27643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F1P5"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM27643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="145" mass="15926" checksum="78A7FD12C0F8763D" modified="2019-02-13" version="1">MDIIFASFIRNRTGVQEIREFLGEKGSHIKIIAKIENHQGVKNFDEIVQAADGVMVARGDLGIEIPPEKVFLAQKMAISRCNLVGKPVICATQMLESMTYKPRATRAESSDVANAVLDGADCVMLSGKFVRYLPANGHYTLLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FDT9</accession>
    <name>A0A3P7FDT9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007343">
        <property type="protein sequence ID" value="VDM26889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FDT9"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="166" mass="18417" checksum="51886BF8C90FA578" modified="2019-02-13" version="1">MANFSTKQKYRQTVMFTATMPPAVERLARSYLRRPATVYVGTAGKPTDRVEQIVYMVQENDKRKKLLEILNDGIEPPVIIFVNQKKGADMLAKGLDKLGHSAVVLHGGKGQEHREYALASLKSGQKEILVATDVAGRGIDIKDVSMVINYDMAKTIDGELSVHVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFR1</accession>
    <name>A0A3P7FFR1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007864">
        <property type="protein sequence ID" value="VDM27167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFR1"/>
    <dbReference type="OrthoDB" id="6249958at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24278" checksum="5242668D46595026" modified="2019-02-13" version="1">MQAMSGTIFDEFAVLVVVVGGGDDDGGGGGGGGASTASFLHLVAVWIKLSMNLYVEGQLVMWEQRNNSEAAISAAACSQLTAAILRGPNPIIATAFVDCDLLDLEKIRVDNEEGIRVTLLLKFDPGNNPKAFQEAEVRRHIESSPFNIDFDADETISINNFDVCKENKHDCSPSANCNWDGVTYTCECNRFFTDGVVMGKLLPGRECYREFPSRLLIESSTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQL4</accession>
    <name>A0A3P7FQL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022563">
        <property type="protein sequence ID" value="VDM35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQL4"/>
    <dbReference type="OrthoDB" id="10496515at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="35" mass="3939" checksum="8B3C231C4E085015" modified="2019-02-13" version="1">MTARSPRETMLLSNTIALADYLVPEQCLQLVEDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FW22</accession>
    <name>A0A3P7FW22_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01024601">
        <property type="protein sequence ID" value="VDM36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FW22"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="181" mass="19888" checksum="8DF41C8738A45399" modified="2019-02-13" version="1">MWQAIGWIVGMQHRVHGIENQVADGPRVIVVNHQSALDIPATYASFGLLVWFLKPILIDRSNRNDSIHKLHDAAKIVKKDQVSVIIFPEGTRGDGKTGLLPFKRGAFHLAVEAQVPIQPVVIAPYSWLDISNRVARGGICDIFILPSISTIGMIASDVALLTDNVRKKMSDVFMSSLPSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G553</accession>
    <name>A0A3P7G553_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021688">
        <property type="protein sequence ID" value="VDM35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G553"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="205"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="397" mass="43167" checksum="EF209B8D8E637D37" modified="2019-02-13" version="1">MTTFDLSSSPVYLGGIADVESHFLEDVVPSKQSFVGAIQKVVLNGAELVLAGGSQKKSDRLKETQLEHWEATTQWQGPPCGDNYSTCAKDRETLKRICRPLGSSYECSCSTPLTHMSFVRHLTASLGDVDLLHNLTAQREISAKAEAMACDALATRLGMASKDLQHDVPGKDNEIGAPLSEEERKEVQAGERRMGDSREAAVLYKGSVLFSGSTVINYHGLIDKDNTVDNVRIQLKTETSDGLVVMIPERSHGMEEFVAISLVSGRPEACLSLRSSHHSPPLNVDTSHSEGKRVTTLKAAQFVADGDWHIVHFIRNRGHISLIVDDQMVSGELAGTDGVLNNEGNIWLGGALERVTTLPWQYQRNFTGCISALFLNEVSIALLGDADLLYGTIASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G9I3</accession>
    <name>A0A3P7G9I3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase 24 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS1522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000357">
        <property type="protein sequence ID" value="VDM18145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G9I3"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM18145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21703" checksum="A1952919D5398304" modified="2019-02-13" version="1">MKRLDELKTHYPVGFHASLIMPALDIAQRQNGWLPISAMSKVAEYLDVPEMRVFEVATFYTMFNRDPVGKYHIQLCTTTPCMLGGVGSDVILETIEKTLNIKTGETTPDKLFTLSQVECLGACVNAPMMQINDDYYEDLTPDDVVRILSDLKVGKKPKHGPQSGQGQRCACEPKGGFTSLRAPPVPPDFKLQAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GUA2</accession>
    <name>A0A3P7GUA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005130">
        <property type="protein sequence ID" value="VDM25482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GUA2"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="346" mass="37794" checksum="60BB1EF1B92B3FC2" modified="2019-02-13" version="1">MDVSQSYDSVLNFEESVDKLVREDELEDPAILNVSKYGPGASTQQAIPVAPIINPNDIWGTGLPHNAGSNHGSSRFDPFLDLLSQQLSSDLAVSGDRKVIQGQTMEPPVDKSSDVNSLSGCFGCNKKEVQPDLGAPHATMKSHPPYQVRPLLGMATPPSEQLQKLLHATKGVVSPQHHFFNMPVTTSLQKVQPTPSRNGFFMVPSGPSTSYSRFAAPPPPLFSSLPHLTSSVHLQKPFPMPPKVSFLPPMQQLHPQHPLFAQFSPPSPLDPSRLSDILFARIEAEQPDKASFDPRFGAWMSPQDQLLVLNCQLRSLNVANPYVEVGFCSYFSTPADLSSECSVCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHK0</accession>
    <name>A0A0R3WHK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS18</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000001701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000001701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000001701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265498at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000001701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="931" mass="103381" checksum="38A3295C7EF5747E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI63</accession>
    <name>A0A0R3WI63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">LIM/homeobox protein Lhx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS272</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000019">
        <property type="protein sequence ID" value="VDM16178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI63"/>
    <dbReference type="STRING" id="6205.A0A0R3WI63"/>
    <dbReference type="WBParaSite" id="TTAC_0000027101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000027101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000027101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
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        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
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    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
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            <begin position="12"/>
            <end position="71"/>
        </location>
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    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="76"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="297"/>
            <end position="369"/>
        </location>
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            <begin position="141"/>
            <end position="170"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="381"/>
            <end position="426"/>
        </location>
    </feature>
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            <begin position="266"/>
            <end position="292"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000027101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="663" mass="73054" checksum="693586B57D5A14BC" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI74</accession>
    <name>A0A0R3WI74_HYDTA</name>
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        <submittedName>
            <fullName evidence="12">Protein kinase C-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS284</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM16193.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN 1 ISOFORM X1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
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            <end position="193"/>
        </location>
    </feature>
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            <end position="301"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000028301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="920" mass="101550" checksum="4EA8A5D203707678" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI77</accession>
    <name>A0A0R3WI77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRUD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS287</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM16196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WI77"/>
    <dbReference type="WBParaSite" id="TTAC_0000028601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000028601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000028601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="117"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000028601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="467" mass="51714" checksum="578867E1C488EC0B" modified="2016-01-20" version="1">MTADQGRGLSPMSKRRKFDEVSDTTQGVLSDADVGISGFMYTRNAGFQGTMKGSISARRLSTLNPRLNGIKLGNFSYSANSIKLGDLYGNRFSIVIRDVAAEDSVLHKAIQDWQKHGFINYFGLQRFGHCAEARTYDIGREIIRCNWEKAIDLILTPTSLDLPVVRQIKERYRRTGDAKACGDDMPQCLEKTLLLGIARHGKSIAALQTLPRNLRQLYAHSYQSLVWNKIASRRIQELGVDEDERALVGDLYFSDCPSIPKGLRSVDSSSELCYDESFAQSTVVVPVADAASAACDVEEVAGDGGGETVFESSKAPTTPAAPSRVTEGGERPLIYQVVLPLPGYDVVFPDNESGNWYTEILCEDLLKIDDFNHKVKDFALPGSYRHLVVKPEDVHYEIREYTNPQKPLVQSDYARMTANEPGSTEEASGDGDTNEKCRALVLEFTLPKAAYATMAIRELMKDVTVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WII6</accession>
    <name>A0A0R3WII6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyroglutamyl-peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS414</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000034">
        <property type="protein sequence ID" value="VDM16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WII6"/>
    <dbReference type="STRING" id="6205.A0A0R3WII6"/>
    <dbReference type="WBParaSite" id="TTAC_0000041301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000041301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000041301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000041301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22623" checksum="F809E48CA7FA9FB0" modified="2016-01-20" version="1">MDAQSKVVVTGFGPFGGISVNSSTTAVLNLQAKWEEIVSHTKFFPELVVLPNVEVSYKAVDKIVSHIWDDLKPDLVVHVGVSAFSSTISLESQSGSGPYMMADDGCLPCQLFCDRQISTKLSLDEPCALLRSRGFKCDISTDPGCFLCSYIYRCSLEKNPYRTLFVHVPTISSAVTADYLGDFLFLLIVILCKSCDVPISSSLVAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIL2</accession>
    <name>A0A0R3WIL2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="11">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS446</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01000039">
        <property type="protein sequence ID" value="VDM16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIL2"/>
    <dbReference type="STRING" id="6205.A0A0R3WIL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000044501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000044501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000044501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000044501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36865" checksum="454CDA1C6B492B5E" modified="2016-01-20" version="1">MSTSQSLFAEKMTVREAINSALKEEIERDKNVFILGEEVAQYDGAYKVTKNLWRTFGDDRVIDTPISEMGFTGIAVGAAMAGSRPVCEFMTFNFAMQAIDQIINSAAKTHYMSNGRVNVPILFRGGNGAAAGVAAQHSQDYAAWYASCPGLKVVAPYSTEDARGLTKAGIRDDDPVVSLENELMYGVAMDTSDEAMHPDFLIPFGKAKIEREGCHITLVSYSISVGDCLEAADQLAKDGINCEVINLRSLRPLDDECIFNSVKKTHHLVTVDRAWPSCGIGAEICARIMEGDVFFHLDAPVYRVTGADVPMPYAGCLEAACTSHASNVITTVKKVLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIW1</accession>
    <name>A0A0R3WIW1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS568</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000057">
        <property type="protein sequence ID" value="VDM16663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIW1"/>
    <dbReference type="STRING" id="6205.A0A0R3WIW1"/>
    <dbReference type="WBParaSite" id="TTAC_0000056701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000056701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000056701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000056701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15576" checksum="B66C2366D8E6C1CD" modified="2016-01-20" version="1">MSTGNRALSGVCEHILYFLSYTVFVLFLPVSVFVCLKVVQEYERAVIFRLGRVMPGSMKGPGIFLCLPCVEECFMVDLRTITFDIPPQESLQKCLAGGDEEREVFEDLQLLLQYQSSLLNYFHENNAEKGGRLRPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ02</accession>
    <name>A0A0R3WJ02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cystinosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS618</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000066">
        <property type="protein sequence ID" value="VDM16748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ02"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ02"/>
    <dbReference type="WBParaSite" id="TTAC_0000061701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000061701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000061701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000061701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38928" checksum="91D0EB755E4BE643" modified="2016-01-20" version="1">MVVFSLTNDSYIASDVVLDPLSVDMALGEYRRFSVQFREPLPVRSTFKFTYRNVAGTYINRTEELPIKPLDPFIVEVGSNRTYQTSIATRKPGVVELGLVSSNLSITHLERLHARITVYHQKSLSILQQIVGWTYFLAWTLSFYPQVVLNCRRQSVTGLSFDFVVFNIIGFACYSAFNIGLFFVSRIQEQYFARHSLGVIPVEINDLFFSLHGVAVMLVVIIQCLFFERGNQRVSKVCIALSCLMILFILTSTLLAAAGVVSWLTALYLYSYVKLFVTLIKYFPQLILNCRRRSCVGWSVGNFILDFIGGVLSVTQMFINAYNYGEFNSCNLEQGILDLWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ17</accession>
    <name>A0A0R3WJ17_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heparosan-N-sulfate-glucuronate 5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000070">
        <property type="protein sequence ID" value="VDM16778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ17"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ17"/>
    <dbReference type="WBParaSite" id="TTAC_0000063901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000063901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000063901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5914444at2759"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047464">
        <property type="term" value="F:heparosan-N-sulfate-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174:SF3">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-glucuronyl C5-epimerase C-terminal" evidence="1">
        <location>
            <begin position="376"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000063901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="623" mass="70597" checksum="A3016E06B91CA360" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ31</accession>
    <name>A0A0R3WJ31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS658</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000074">
        <property type="protein sequence ID" value="VDM16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ31"/>
    <dbReference type="WBParaSite" id="TTAC_0000065701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000065701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000065701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271770at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000065701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46374" checksum="F357CBC36742DC27" modified="2016-01-20" version="1">MGLSFSKSSTNTTAKEGEEHETGFQHIANTIRRSFRVKRQTADNANRSSLRASASVDGVTTTSTRVRPGIPESFHQQNTASVKPAAPAKETLKQPAKSPATPLETKAATPKAPEVIPAMAMVTEASRNAASISESQKKVGTDEERDKEMDKAMDMLKGAIRAEEEQGEKKADIEGKERQEEEKEKLHHVGDILSRLAPATTPTSPEAASAIAKMTEAPRNAAFIPESPEKVKMNEESDKDSERAMGMLKGTYHVEEEQGEKDDRRVKEGQEEDEEEEGEKLHHAGNILSQLAPADTSGDKTPETDTPAKPTVSLLAALEKRKAMKERKEEDNEESDEAEKDANLTHGVTNVLESIAYQSSAIKSKEAANLMAAFTLPPQSPSEGEVDEEEDRQGEKKTEKEEEEANGELKKEERDKKAVEVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJD7</accession>
    <name>A0A0R3WJD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS785</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000098">
        <property type="protein sequence ID" value="VDM16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJD7"/>
    <dbReference type="STRING" id="6205.A0A0R3WJD7"/>
    <dbReference type="WBParaSite" id="TTAC_0000078401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000078401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000078401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000078401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15023" checksum="9B52584B907EC5F1" modified="2016-01-20" version="1">MRGSYYFVIVGSDDNPLFELTHGLAPKTDFRYLNQFIAHAALDMVDENMWSSSSTYLKIVDKFNEWLVSAFVTPSDILFLSDKIRQFFQDVYEIYVRLSLNPFFEPNSRITSEAFFRKVQQLARNHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJK0</accession>
    <name>A0A0R3WJK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-responsive element-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS851</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000112">
        <property type="protein sequence ID" value="VDM17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJK0"/>
    <dbReference type="STRING" id="6205.A0A0R3WJK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000085001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000085001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000085001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3069995at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000085001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="61135" checksum="8FCD18FA4D5EB312" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJU0</accession>
    <name>A0A0R3WJU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5259</name>
        <name evidence="3" type="ORF">TTAC_LOCUS958</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000141">
        <property type="protein sequence ID" value="VDM17232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="UYWX01006788">
        <property type="protein sequence ID" value="VDM26578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WJU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000095701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000095701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000095701"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000527301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000527301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000527301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM26578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000095701-mRNA-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000527301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13485" checksum="45AA74B1943829DC" modified="2016-01-20" version="1">MTVENLASIFAPNILRQADYDPDVEMSVTPVITLTVAGFIRRHEELFRYKLAHFAQLRCAALASTVAGATGPAGAAMPLVVQGRMGESYSEPAAESAGGSTSSVHSSRCKSGELGRIGLSWTGLGWSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJV7</accession>
    <name>A0A0R3WJV7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS976</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000145">
        <property type="protein sequence ID" value="VDM17256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJV7"/>
    <dbReference type="SMR" id="A0A0R3WJV7"/>
    <dbReference type="STRING" id="6205.A0A0R3WJV7"/>
    <dbReference type="WBParaSite" id="TTAC_0000097501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000097501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000097501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6066210at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000097501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15358" checksum="B728508BF512770B" modified="2016-01-20" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSTAVSALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKK5</accession>
    <name>A0A0R3WKK5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1250</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000235">
        <property type="protein sequence ID" value="VDM17696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKK5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKK5"/>
    <dbReference type="WBParaSite" id="TTAC_0000124901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000124901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000124901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6245854at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000124901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59353" checksum="AA7C464E4BA03FDD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKN5</accession>
    <name>A0A0R3WKN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000245">
        <property type="protein sequence ID" value="VDM17736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WKN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000127901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000127901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000127901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254820at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000127901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30415" checksum="DF36D6CDE4271D6B" modified="2016-01-20" version="1">MQNGDINIRPRLNNRRNESLRQSSCGNTVPAPRLRFRSPFHGSPTAENLDSFLDTKTLHVNFADYVSQERISAKCPIKKVHASQLAANNPIEDRWNCGFIQMNDKISKFVFSVIDGHSGSSCSHALAWIVLEYIAATLVGSEDLATAIVRLESPPPDCELPPRVVEQPILYNNKGRNVTKRFLTNRLPPPDVRKFLVERLVIFMQELTLSPLSEKQIFTGRVSRVRVLTPKLAHCLLLPSNKVLKCLRTRRNLLSTSNPSRSHLSEPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL11</accession>
    <name>A0A0R3WL11_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1429</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000309">
        <property type="protein sequence ID" value="VDM17980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL11"/>
    <dbReference type="STRING" id="6205.A0A0R3WL11"/>
    <dbReference type="WBParaSite" id="TTAC_0000144201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000144201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000144201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF239">
        <property type="entry name" value="ANNEXIN A7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM17980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000144201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56239" checksum="99978B2C122AFC66" modified="2016-06-08" version="2">MRQRTVMEVRESLTQAIGHILKAIPKPQPPPPPPPQPLQQPAVEFPILKSPLSQVFQQFNSYATINSNIVDELSCADVGKVIGGDLQDADDRYVLTIELEKKDRKPNKLKSDKKCSKVTVPESYYSLSPYFIPPKGHEVETVVRQGRNQKAAAIELKGEENPSDKVENAYFETEEYKSEGTLKPTPNFDCNADCQRLRKAMKGLGTDEKGIIDVLARRSIRQRLDIVKQFKTLYGLDLINELNNEISGKFFKVCRALCLEPEVYDAEELREAVEGIGTDEDCLIEIICCRTNAQIAKIKEAYKKIFSRDLEKDVHDDTSGHFQRLMVSLLQGNRNESPTFDRKKARKDAEELLAAGEKKSGTDESKFNEILISRSNAHLRAVFEEYEKVSKKTVEEALKSEMSGDLLRAFLSVVRSVQNKPAFFAKTLHRSMKGMGTDDDSLIRVIVTRCEIDMVQIKNAFKAEYEETLGEFIKDDTSGFYRLALLTLIGEETLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLC6</accession>
    <name>A0A0R3WLC6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1551</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000372">
        <property type="protein sequence ID" value="VDM18198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLC6"/>
    <dbReference type="STRING" id="6205.A0A0R3WLC6"/>
    <dbReference type="WBParaSite" id="TTAC_0000156401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000156401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000156401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="150"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000156401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29014" checksum="7429383DD2824FCB" modified="2016-01-20" version="1">MGNCLTCHDQKEGIQCHGDNGMTSMGANTQGGGQTLGQAPFSRHYGPSSDATSVSVNQSAIVPTSRGALQPSQQYSVNLYGMQNGPQQNASFAYGPTQPPTTLDQQLAEQSPRVVRVHALYTYVAQNADDLSFQKGDVMLVESGLSEAWWLARHLRTGQQGYIPSNYVTVENGQSTQMEAWYDITRKDAERMLLMPGLPQGTYILRPSSDARNYALSIRFETDRNLYAIKHYKIRTRDKGAGFYITNRTNFASVADLISHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLD3</accession>
    <name>A0A0R3WLD3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1558</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000374">
        <property type="protein sequence ID" value="VDM18209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLD3"/>
    <dbReference type="STRING" id="6205.A0A0R3WLD3"/>
    <dbReference type="WBParaSite" id="TTAC_0000157101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000157101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000157101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6084240at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000157101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32071" checksum="E1633C4A97379CBC" modified="2016-01-20" version="1">MPAETEASDCIVASANVPVVGSHNRQVSLHVGDHLLLECPIWGSSEGPVHLGSENQPSSFHDGGLMNDIIYQWNIQGLPEYAVAMDTRFRFLEGGRVVELTQPVTKSDAGIYQCSGVTGFGQKKVDFEVHVADTNDNLICVKAYPGATDRNQALCLMDPNLRPDTIMTTEAELGSAVDLSCEAIGREPIKYLWFMGNAVADWISSNQGVRGPTLHIERVGREHIGQYVCQVKNPIGTLNYTFRLTVKEPPSAIPRIIGEVENQTLIVGSSGVLTCRVKCSCTEPIIQVRSHHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH5</accession>
    <name>A0A0R3WLH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1600</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000397">
        <property type="protein sequence ID" value="VDM18269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000161301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF141">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="11">
        <location>
            <begin position="270"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="42768" checksum="4F99F4B50D94CF63" modified="2016-01-20" version="1">MSKRVADKPLDYDNWDAPDEPVKPGVFEKADEATIKARNIIIARRKSGQPIAQSRRGLFKTLDVFGSPQSTPSPTLFITSSKSESQNDVYLAKLAVLNKEVSAWISKHVAADPYCILTPIFDDYAKHLSSIESPASDTITEKQATQSTAAPAPISTSAGGCVAPEAAVPPIQPVTTAATTTTTNGFSFKFQTTTTTESVVSRPPLFQFGLASTTSSNSTSPNTQMFSFASAPVKQAENSDSATTTNAALGIDQGDEEEYIPPKPEVREIKEEGSVYTVRCKLFYKKADQWTERGLGNLHIIPSSDEKFQLLVRADTNLGNILLNIMVTKDIPMQLQKNNITFACVPSPPLPGNSKTKEGEDAASPPRPVPMLIRVKSPEAAENLLAEIDKHRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK6</accession>
    <name>A0A0R3WLK6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1631</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000417">
        <property type="protein sequence ID" value="VDM18315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLK6"/>
    <dbReference type="STRING" id="6205.A0A0R3WLK6"/>
    <dbReference type="WBParaSite" id="TTAC_0000164401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM18315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37051" checksum="52F40659553F11E5" modified="2016-01-20" version="1">MRDFVMNCISKRGAIDARLIVMEIVLGMEGNEESSSEGGMSTQPHHPQQASLPPPSMLQEEQHLQHEPYDANTNIPTTCAQSTNPQMSGLFSIRRAVGLSRTNLPFPARKRLFSWLVDHLREPYPSEEEKMMLAMETGLSRTTVNNWFINARRRYVKPLMQGRLVLQSGVFKTVSGDGAPAAKSPNSPTQSSGVPIAASGGSSSSNFHNSDTAASQFPSQFAAASRLSLHQDGVFPAPPPPPPPPPPPHIGGVSSSSALSAMAAAAVAFAGGPRSFVDNGGDLKLTSSRPAHLPWQGIPGLDMGSPKRCRRTSDLSSSSSPAEPTPRYPQKSAGHEKPPLKGEVSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM49</accession>
    <name>A0A0R3WM49_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1824</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000535">
        <property type="protein sequence ID" value="VDM18564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM49"/>
    <dbReference type="STRING" id="6205.A0A0R3WM49"/>
    <dbReference type="WBParaSite" id="TTAC_0000183701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000183701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000183701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="2">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000183701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10318" checksum="7058849E4D1093B2" modified="2016-01-20" version="1">MFQLTLYTISCSSVLEFDSDVDDPSTPASQGFGNYVGQATLKYDCEGNDQGCISGKAGEAFYVLEVDNDGSGWTGVVSADGSRQGFLPTTHLSITLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMW8</accession>
    <name>A0A0R3WMW8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2093</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01000750">
        <property type="protein sequence ID" value="VDM18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMW8"/>
    <dbReference type="STRING" id="6205.A0A0R3WMW8"/>
    <dbReference type="WBParaSite" id="TTAC_0000210601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000210601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000210601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="199"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000210601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="795" mass="90457" checksum="CBD14BDCEEDA4F42" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNZ6</accession>
    <name>A0A0R3WNZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CNNM transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2471</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001120">
        <property type="protein sequence ID" value="VDM20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNZ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000248401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000248401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000248401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905941">
        <property type="term" value="P:positive regulation of gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032026">
        <property type="term" value="P:response to magnesium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132923" evidence="10">
        <location>
            <begin position="24"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="153"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="420"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000248401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59504" checksum="DF3274706B33BCEF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPB3</accession>
    <name>A0A0R3WPB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2588</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001250">
        <property type="protein sequence ID" value="VDM20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000260301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000260301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000260301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263911at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000260301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73145" checksum="67908377F135FDBE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ26</accession>
    <name>A0A0R3WQ26_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2851</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001591">
        <property type="protein sequence ID" value="VDM21323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ26"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ26"/>
    <dbReference type="WBParaSite" id="TTAC_0000286601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000286601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000286601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="112"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000286601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33157" checksum="60A1075FD9022C32" modified="2016-01-20" version="1">MLANSMTTLVTMISDTEKDFIAVERCRELTEDTPFEAAVVSCSGVVPSHLHHPLSTHISQTTLSACPQVEVAWPKEGCIVFENVHLVYPSMMTSTQQTEVIMEGNEKENFALNGVSLKIGAGEHVGVVGRTGSGKSSLLRVLFRLVPHLEGPITNPQIARLKNFRGATGTVKVDDIDVRQVPLNILRSRMLCVSQDPFLFSGTVRDNLDPDGLYSDGQLADILIRCGLVNEEGETLTLLSSEVGEAGRSLSAGQRQLLCLARALFHHSRSQHSVICLDEATSSLDDTCEKKIQVGRVLCCPYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSD2</accession>
    <name>A0A0R3WSD2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002815">
        <property type="protein sequence ID" value="VDM23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSD2"/>
    <dbReference type="WBParaSite" id="TTAC_0000367201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000367201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000367201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6231388at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000367201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31135" checksum="EB727FDF713D250F" modified="2016-01-20" version="1">MATKSRERSTPSQVNSKVVEFVCSLYEADPKITLAQICLRLQGEMSVTVAQSTAHKYLRGMVFTRSILPPPDYTSLEAREETRQYISAISNYMQQGKEIIWLELHIHSLAAISSNLGLLHASFKRGPYTKQDQEVWIHQHLQPELLTDAVLVSNAFEGANISAVTPVPRRLRLAPLHTDRLNPCEAYWSRVTERVKTRLLSGEAHLPAGSATDENQRLGCLERLLTHAMATVAVSNSNNEADCKGEVVEEDVCEKAVRDSTESLTDVLQLVTGLKVEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT53</accession>
    <name>A0A0R3WT53_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MRG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3928</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003308">
        <property type="protein sequence ID" value="VDM23784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT53"/>
    <dbReference type="STRING" id="6205.A0A0R3WT53"/>
    <dbReference type="WBParaSite" id="TTAC_0000394301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000394301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000394301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287997at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MRG" evidence="2">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000394301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21050" checksum="EC938B85F7FB083B" modified="2016-01-20" version="1">MLATGQSSLRNGLDPPLRSQFNILSSEEIAKNPLLPCLVYDAVYILRLIVRLPALINQMSLTKCRRSIVLRHLYLFIAYLDETREFWFTSTRPALAAPVLSSASTSTSTDATTIPHGVKRMEPRSGPSTANAINTGATSPAICSVPKKRRRTMSSEPVSKTSMPPPSSPPPPSLSSLTSSELSLGRLGLSVLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT60</accession>
    <name>A0A0R3WT60_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3935</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003320">
        <property type="protein sequence ID" value="VDM23797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT60"/>
    <dbReference type="STRING" id="6205.A0A0R3WT60"/>
    <dbReference type="WBParaSite" id="TTAC_0000395001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000395001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000395001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193300at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000059">
        <property type="entry name" value="RIKEN cDNA 6430531B16 gene"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF9">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000395001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30242" checksum="39A566947CA0B5A4" modified="2016-01-20" version="1">MVNELDQKVLRDLYAWVDSIPLSRPKRNINRDFSDGVLVAEVIRHFFPKYVDIHNFQGCSKIDGKRNNWQLLNWKVFSKFSFKLTDDVVESLVNAQPGTIEKLLLLLRSKFREHESGLDSNDNGLPNPPSRVVLPSLITPASNLQRLRRIPSVRNDTSTNEKSLPVFVKKGSQVLMPSNKAFSISKSLNRLSWRQPNATNGPRDIAAQDMLQVYEQKVQECLELQETVDILNAKLRRMQHLLQLKDMRINELQSRLEYFSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT71</accession>
    <name>A0A0R3WT71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3946</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003339">
        <property type="protein sequence ID" value="VDM23824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT71"/>
    <dbReference type="STRING" id="6205.A0A0R3WT71"/>
    <dbReference type="WBParaSite" id="TTAC_0000396101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000396101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000396101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM23824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000396101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39942" checksum="693669E7A2352B08" modified="2016-01-20" version="1">MALDDHGNEVGYVVISFSYSSSRKLFVGGLHQSTNTNGLHNYFSKFGDIEESIVMMDNRTGRSRGFGYVKFREPSAVDEVLSKKIHVIDNKEVDPKRCNINMRGKNKRSLKIFVGGIAFEHNEETIRNFFQCFGNVTDVNLLSNPGRPRHRGFAFVGFDDEEVVKRLIKMHFVNLHGKQVEIKPMEPPNTQKTFGYMSPGMLNAPNGRSGRGYSRFGSFHQHSIPYGGWNHWGHSSNVDGKADFLIDGNGGGNGWTQMVDQHNNPAWGSQPPPPNQWNGPQSPSPLNGCWENQIAAAAAAAAFQSNGFPPQQQQQWGSQSSSSRRECLVSSFFLLRMRSKVSFVEDDLSIRFVVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTB3</accession>
    <name>A0A0R3WTB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3989</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003425">
        <property type="protein sequence ID" value="VDM23925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTB3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000400301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000400301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000400301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000400301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="144" mass="14958" checksum="4B7A761F8F75E28F" modified="2016-01-20" version="1">MGYGGGASGVFAGSGPLLLQAGGAGFFGLINPWLAGILVCLLPLISALIWACWRCKPGCCPCCVGGAGGKAAGGKFHDTMDRISAGLWAAPPADKDLLVAKLLVMVSTHDISNNEGWTEDLRVNFASQSHLLPIDAERWMLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH5</accession>
    <name>A0A0R3WTH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4780 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003565">
        <property type="protein sequence ID" value="VDM24066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000406501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254633at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32681" checksum="596FF1E493B417C5" modified="2016-01-20" version="1">MGTLHSVIRGEKSTKSPESKVKESGRLSYYGRNCAADKDSRSLNRRTSSHQVDSNLTRVPNNSQSRTDSLGTDPSLVESPLDTTINSRGAGRCYELKKSQRPSRDADVRRTRLTDVSPAGGRKKNSRPRRENSIQRSVANQVGDQVTQSKFIQAGVGYAFMRDNETNTIQPIFPNSTPVGVKKCVLQPSMVTPCLAPSQAYGDEGKVHDDATRRKQTEAINKMLNDPDDRRIRTICERFQCDLDIYAKNLIGGFMQYTVDIAAPNASNLLGCAKNLDLALGWHIAQQLNHGNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTN0</accession>
    <name>A0A0R3WTN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003672">
        <property type="protein sequence ID" value="VDM24183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000412001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000412001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000412001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000412001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="63" mass="7165" checksum="97CD2CBA9CD74E38" modified="2016-01-20" version="1">MRRLSNTQSNAVLIPVALLVIRTTLPNRHSSSVQVVWSTQELLENFGQILRVSRLPSYLSFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU91</accession>
    <name>A0A0R3WU91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anoctamin-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004135">
        <property type="protein sequence ID" value="VDM24664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU91"/>
    <dbReference type="STRING" id="6205.A0A0R3WU91"/>
    <dbReference type="WBParaSite" id="TTAC_0000433101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000433101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000433101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000433101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14103" checksum="E824E11618FB364B" modified="2016-01-20" version="1">MVISDDAMVLSPQIAQDLQMCAAFLGIDALVADDEDGDLLDPKIGLPCSESRNPHFPGKMLIIQPSDMAAKEFYILVEKSRINERTFALFTVSHELYIRRRKSDINEVQQVKIRAKTGCELKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUP5</accession>
    <name>A0A0R3WUP5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004525">
        <property type="protein sequence ID" value="VDM25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUP5"/>
    <dbReference type="WBParaSite" id="TTAC_0000448501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000448501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000448501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000448501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13442" checksum="13D9B9FA9EDB6899" modified="2016-01-20" version="1">MRSHHRLILLPNQRRRRSLSRRQHLSSILRMPLQLALPTSMTAGRRMKNSAPLQVLALSEAEPLERSDGFSLVWLCASCRMHPTTKYPTVFTLCQHFVLHYCYSVVDSNCCFLPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUR3</accession>
    <name>A0A0R3WUR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CG-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4488</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004576">
        <property type="protein sequence ID" value="VDM25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000450301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000450301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000450301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248994at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000450301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34015" checksum="3811E9690F74BBC8" modified="2016-01-20" version="1">TSKIGCRSKIYFYSQDSQLHVRRYDFRHNHEVRPDLVHFPPKRRRTRKEKEAEEAATAAASAPIPLIGTAIPGTDTVSGPLSLGMVKCEAALRGSSARILRQPTNFEFATEEVDVGVEGEEVDEDDEFDDEDDDAQDDLPQLYLPSNGCGHQNFIEEDFRSVFQMHDFEVPLQPQQSDASSCFSLPPGAYHFYSGSLQTPQTVDMSTESLVPMERGNFETEEENLALETTKSLSREPLEAMLPSRLDPQLQRLGELASSCGPIRFASRLRELKALGDKWTRENEILMLRSRSYGGAGVVIVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV05</accession>
    <name>A0A0R3WV05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4579</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004806">
        <property type="protein sequence ID" value="VDM25223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV05"/>
    <dbReference type="STRING" id="6205.A0A0R3WV05"/>
    <dbReference type="WBParaSite" id="TTAC_0000459501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000459501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000459501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000459501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19921" checksum="3DCF5EFF6A1CED01" modified="2016-01-20" version="1">MATQSKQKKLKGGRQKLKLFRANEPLKSVLMWGINHSLTTLQHMKPRAVLLKDDFKAYLKIKVKGHLFNKENMPSRFKFKEYCPLAFQNLRERFNVDTNDYWESFTRYQPLWDSVSSKSGSKLLVTYNRHYVLKMISSEEVEQMHHFIESYHEFLLYIDIRFSTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV25</accession>
    <name>A0A0R3WV25_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cadherin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4601</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004861">
        <property type="protein sequence ID" value="VDM25258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV25"/>
    <dbReference type="STRING" id="6205.A0A0R3WV25"/>
    <dbReference type="WBParaSite" id="TTAC_0000461501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10082" checksum="2986C8BB52BDEE98" modified="2016-01-20" version="1">MLFKAKEIKPNILIGELAKSRGTDPAKILLGPGGDSHILQNTGKRKPKPPPSTPLDGYFDASTSSPEGYSFGTNPTDMNSLTSSDWGDEGCVSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVM1</accession>
    <name>A0A0R3WVM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4795</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005357">
        <property type="protein sequence ID" value="VDM25658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVM1"/>
    <dbReference type="STRING" id="6205.A0A0R3WVM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000481101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000481101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000481101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000481101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="53" mass="6288" checksum="73561CB991284334" modified="2016-01-20" version="1">MESELERFNQQNGALDLSIEELKEKLKSTVGELKAERQLRRNIQATVRRFRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVN2</accession>
    <name>A0A0R3WVN2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4807</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005400">
        <property type="protein sequence ID" value="VDM25691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVN2"/>
    <dbReference type="STRING" id="6205.A0A0R3WVN2"/>
    <dbReference type="WBParaSite" id="TTAC_0000482201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000482201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000482201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="188"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000482201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36409" checksum="1E07B35424126F4B" modified="2016-01-20" version="1">MGLYQIFGYNLSSILMGTFEQFDEGIFELDDNHKLDLPIPFSALTPTIRSLDDALKHDLSLSEEEIAQDAGERPIKNVKRSTIIDEFGFKIDRDKEGLPQPLVESVENRRIWMACLEFSYTNRLNDSNEVGEECSSEDSLWSRLLPRISTSPRLTELVRGIEDPQNSGERLKWSGVPNLGSKLSPRNGIPHSMRAQIWPRLTRAYEQQRTSNEGGNGGGKKCPLSYAEVIRHSSSVSPKISRQIEKDLLRTMPNNVCFSSASSIGIPRLRRLLTAIAWVYTDIGYCQGLGAVSHSSRSAIRTFMDFFLSHLNSMIMLSSSFSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWM2</accession>
    <name>A0A0R3WWM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006394">
        <property type="protein sequence ID" value="VDM26355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000516201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000516201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000516201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281533at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000516201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12467" checksum="03CEC1A2513F62AA" modified="2016-01-20" version="1">MRFQMQPSFTKLSSGIYSDPDTCYYDYRRSRCYSRFSICTRILVRTSDGSTSSCTLRAIRRLPATPQLLQRIPPHLHHVLRKAQFARTNDEERFSACLRFSQQGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXL0</accession>
    <name>A0A0R3WXL0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5483</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007700">
        <property type="protein sequence ID" value="VDM27072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXL0"/>
    <dbReference type="WBParaSite" id="TTAC_0000550001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000550001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000550001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000550001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21608" checksum="27178BE7F3196EFE" modified="2016-01-20" version="1">MDLSAGDTQNLTKPNLIDMDFLKLFNDEVEVLSGLANLEMDLLKGNTAAVGREDLICLLMQESHRLAEEQQRARGNCTQIRNERSSLTSLDGLKIVTKLLLRLHSGGDSASDSRQRRRKAESSTDSGLDEDVNASVTTVVESRVSSTLEEKNECVSGTILGLNEEEGKEAILRGFLDDVEKFDGVCTQNCAEICLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXZ5</accession>
    <name>A0A0R3WXZ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5620</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008254">
        <property type="protein sequence ID" value="VDM27337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000563501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000563501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000563501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM27337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000563501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19847" checksum="AEE9DDC28D79C845" modified="2016-01-20" version="1">MNSWVSRNSQQILERNPSKAKFDVHRATFMYLFSEMVKYAMQTSKNLDDAQAKLASFGAPIGRQMLDLVFLRERMQKREIRLLSFLIFLKGVFWRCIFGKEADDLERDGLDEHTYYMIEREPMVNKFTRFTYEPSESERKNVPLNLAAFNCGIIESALTCAGFLHALLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYN4</accession>
    <name>A0A0R3WYN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5861</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009397">
        <property type="protein sequence ID" value="VDM27822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYN4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000587401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000587401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000587401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF1">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000587401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15609" checksum="3A8E904EB2C91BAA" modified="2016-01-20" version="1">MKNPPSVVKLVMEAVCIMMQEKPERKPDPATGKMIEDYWGVSLKLLGDLKFLEKLKTYNIDNIPPQVIKRIREVYIPNRDFNPKIVRNASTACEGLCKWIIALDKYDIVSKVVAPKKARLAVAESELDAQVGCCQLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYR3</accession>
    <name>A0A0R3WYR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5886</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="UYWX01009565">
        <property type="protein sequence ID" value="VDM27890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYR3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000590301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000590301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000590301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133087" evidence="3">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000590301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14241" checksum="0381DB8DAD15651A" modified="2016-01-20" version="1">MVSQMNIFCGGLVAVLSLLADSVVRFTVAPECEIAPCTSLLPTSRMDITLPPPGASTDVWVRRRMLYIMRGATRYRLTHAVLPNDTRLPGTNHVVHRDRRITVMCRPRPECLPQSQPGDGSYSYGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ18</accession>
    <name>A0A0R3WZ18_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cleft lip and palate associated transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5992</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01010103">
        <property type="protein sequence ID" value="VDM28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ18"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ18"/>
    <dbReference type="WBParaSite" id="TTAC_0000600801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000600801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000600801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000600801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22420" checksum="368A05C0CBF97476" modified="2016-01-20" version="1">MRKRRLSRTINLLTGQTDAPSDLVASKDTPVDARFLPPISHWHPNLTVNLIDDHTPWIRESVPSPINEYIKWYEPTNQYYPAVYINDFWNLNEEYMPVNKTTPELTFRLTVAPLSLFKWQLYLSQSMRKSWFPDLLGQTEDDKFNEDEDQDTMKKTFLETNPYLLGLTVVVSIIHSVFEMLAFKNGKSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ24</accession>
    <name>A0A0R3WZ24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKcGMP_CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5998</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010136">
        <property type="protein sequence ID" value="VDM28150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ24"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ24"/>
    <dbReference type="WBParaSite" id="TTAC_0000601401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000601401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000601401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM28150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000601401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12176" checksum="8BA58E1C5773F0E7" modified="2016-01-20" version="1">MGIISFFSPQADRESQLSGDGGNVEDMLLSMLDERDRLMVGLKEAREELQAAQLRLRDIEKERDILQTQLSNVVPTVSLVPFFHLYNQAFMNDHNSKFQTFQSPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ75</accession>
    <name>A0A0R3WZ75_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LTV1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6057</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ75"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ75"/>
    <dbReference type="WBParaSite" id="TTAC_0000607201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000607201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000607201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000607201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44684" checksum="49BE6A5356C8C215" modified="2016-01-20" version="1">MTDVPECYNYGVFFDDGYDYMKHMKSMKEFVQDPNYVIENEEDAVIPDNYAPPAVEMVVSDDPVDEEFEIPSDDEMTTDGDELEDNFVELAGGKRVRLNDEDSGDDDTARDSYEIRDVKPTPSTANLPLHKIRLMERYLWGAEVEEFPMEDPYGISTHQNPVAVSTARKGRPLTDGEELLEKQFGKLMQVTKSRSGFDFHSAMSGTSVISENLQSAVRADEIMISKRHPKTIDLDSLDDHLRVATLSRLDEMLEPEGDPLKDWVGKERVTMATITTNYQAMGGEVSKEPEVLAMPKLKSSSKPAKTEVEDVNSSLESEKGSDYESEMSAEVNLHRRIKGETTEEKRARKAALKAQKRERQRIKKTNRTNFRREHVLLSKTGKSAYSNGGRVFMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZE8</accession>
    <name>A0A0R3WZE8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6151</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZE8"/>
    <dbReference type="STRING" id="6205.A0A0R3WZE8"/>
    <dbReference type="WBParaSite" id="TTAC_0000616601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000616601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000616601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976048at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="158"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000616601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45118" checksum="09C75BB8F9A61924" modified="2016-01-20" version="1">MHVLVHTVFKFRSILPISFHKAICFSVQCRSYSAIVPIAPYLLDRTKPPEEILKNLTPDDARRLEYIKAEHDMLLASGKPAPLNLSALDYLELLCCASLSARNRYHLFRFKVSKRKESKKAKLAIKAENESSRELTQKNQILRMITSSPVRMHHDDWVGAELRTAEDSAQTLVFDCSHDSEMRIMDQKNLARQMAMAFAHNRTIRPFPFHFMFTSLVPGTNQYRFFEEAFGTCSSPGDSKCLESCLFTVRSEHFSEVMKDRKLIYLSPNASRSFQNGEFDHDATFVVGGIVDRAIRRPITYAKARRAGTFVLHFLRSIAFSGWECIRLPLERYLHWRSGSKTLTLVTIHAILATAKETNGDWKTALERNIPLRFLRDHDSVQRDINKLFQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZI2</accession>
    <name>A0A0R3WZI2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6190</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZI2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000620501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000620501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000620501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6231256at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097723">
        <property type="term" value="P:amoeboid sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031272">
        <property type="term" value="P:regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000620501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45791" checksum="49044EA63D4F703C" modified="2016-01-20" version="1">MINIDPQISSKGEKKCLDNYTACVPPVQGGSLPPADNCAHNHSNTKISISNNNELLDSYISRLWSVREKANRALMLTSDEMTSICRSVRALFLTQPGLLDLGGPIKVCGDIHGQYDDLLRLFELCGLPDKVNYLFLGDYVDRGRQSLETICLLFCYKLRYPTRFFLLRGNHESQAVSRIYGFFEECRKRFSVKLWRTFIDAFSCLPVSAIIENQIFCCHGGLSPEMLTPELTSLADLKRKIREIVRPCDVPDCGLLCDLLWSDPWYLESVGDGREPRGWEPSERGVSYMFGPDIIDRFLDRFNLDLICRAHQVVEDGYEFYANRSLVTIFSAPNYCGEFDNAAAVFCLNRAAAAPNYPYDSTSSPRNQEDTELEGSFHILRTDVPGGVRPSSSAGLTMHPNSGKEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X031</accession>
    <name>A0A0R3X031_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020303">
        <property type="protein sequence ID" value="VDM30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X031"/>
    <dbReference type="WBParaSite" id="TTAC_0000645301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000645301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000645301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000645301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13571" checksum="CF05F87A45568A0D" modified="2016-01-20" version="1">MKAINVIQNGLFTELCFCSCYRRGGPIFEADAKAVSADGSGGMHLTLRIEVDAIPFCFALIGASGVIVMEVDEVLSAFERDDKFACRTKIFACENPVVAVHIKYGGRQLRNGDLWSLYTGVNTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0C6</accession>
    <name>A0A0R3X0C6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6559</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020308">
        <property type="protein sequence ID" value="VDM30786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0C6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0C6"/>
    <dbReference type="WBParaSite" id="TTAC_0000657401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000657401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000657401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000657401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="44050" checksum="2C3FDEA67F73BABB" modified="2016-01-20" version="1">MALPCCTFARVSESDKARSEANKQIDKLIEKEKRNFRSTHRLLLLGAGESGKSTIVKQMRILHIDGFSDAEKKEKIVDIRKNLRDAICSIVGAMPNLKPPIDLKNSENAPIRNYMLEEASKNDFDFPAIFFSHCRQLWSDAGVQEAFERSNEYQLIDCAKYFLDRSMELGKPDYIPTEQDILRCRVLTSGIFETKFTVDKVQFHMFDVGGQREERRKWIQCFNDVTAIIFVAACSSYNMVLREDPNKNRVRESLELLGSIWNNRWLKNISVILFLNKQDLLAEKVKSGKSKIEAYFPGYANYQAQADVLAEYSDEDPEIVRAKFFFRDEFLKVTADSNNGRHYCYPHLTCAVDTENIRRVFNDCRDIIQRMHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0T5</accession>
    <name>A0A0R3X0T5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6755</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020321">
        <property type="protein sequence ID" value="VDM31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0T5"/>
    <dbReference type="STRING" id="6205.A0A0R3X0T5"/>
    <dbReference type="WBParaSite" id="TTAC_0000677001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000677001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000677001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="411"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000677001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="715" mass="77306" checksum="928F427368C2E0FF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1A5</accession>
    <name>A0A0R3X1A5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAC3_GANP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6953</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020334">
        <property type="protein sequence ID" value="VDM31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1A5"/>
    <dbReference type="STRING" id="6205.A0A0R3X1A5"/>
    <dbReference type="WBParaSite" id="TTAC_0000696801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000696801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000696801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="422"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000696801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="680" mass="74899" checksum="E81AC6A3C90D1E73" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1J8</accession>
    <name>A0A0R3X1J8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldedh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7073</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020343">
        <property type="protein sequence ID" value="VDM31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1J8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1J8"/>
    <dbReference type="WBParaSite" id="TTAC_0000708801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000708801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000708801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000708801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="36798" checksum="8CB10773B6C6916B" modified="2016-01-20" version="1">MQRPAIKFTQIFINNKFVNSLSGKTFGVVDPSTEKEVCCVAEGDAADIDSAVKAARAAFLRDSPWRCMDASQRGRLLYRLADALAANVDYLSQLEALDAGKPLESARGDVDFAIDTVRYYAGYADKIHGKVIPCNGDVICYTRREPVGVVGAIIPWNYPLDLIAMKVAPALCAGCCIIVKPAEETPLSALFFAHLVEQIGFPPGVVNVVPGFGETAGAALASHPEVDAVTFTGSTAVGHSVMLAGAGTFKRVNLELGGKSPLIIFADADLDKAASVAFEGVMENAGQCCVAATRTFVEASVYEEMLERFKRLAEQRVVGDPFNSGVGQSQPQPYLFSSASATSDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X243</accession>
    <name>A0A0R3X243_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS7318</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020362">
        <property type="protein sequence ID" value="VDM31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X243"/>
    <dbReference type="STRING" id="6205.A0A0R3X243"/>
    <dbReference type="WBParaSite" id="TTAC_0000733301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000733301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000733301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="271"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="414"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000733301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70391" checksum="C5054C2A55E76885" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2B4</accession>
    <name>A0A0R3X2B4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020369">
        <property type="protein sequence ID" value="VDM31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2B4"/>
    <dbReference type="WBParaSite" id="TTAC_0000742101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000742101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000742101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000742101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12540" checksum="A0E7B3106ACB3921" modified="2016-01-20" version="1">MRFRPLIQSKHWREHEIEATVTAISPEIPIRADFVVAFVHKTPKVVSTENQNRLHLWEIVYSNVSSAHLSAWGDGGKANLCLTYLYQTQGNRTTKILLYLFRLRYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2M9</accession>
    <name>A0A0R3X2M9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7541</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020381">
        <property type="protein sequence ID" value="VDM31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2M9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2M9"/>
    <dbReference type="WBParaSite" id="TTAC_0000755601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000755601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000755601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10002389at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000755601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="59719" checksum="BFB155869D5E0087" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2X9</accession>
    <name>A0A0R3X2X9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7658</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020392">
        <property type="protein sequence ID" value="VDM32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2X9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2X9"/>
    <dbReference type="WBParaSite" id="TTAC_0000767301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000767301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000767301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
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        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GAE_dom"/>
    </dbReference>
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        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="743"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000767301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="877" mass="97156" checksum="4B4A1DB17403ECE0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3D4</accession>
    <name>A0A0R3X3D4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7837</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020410">
        <property type="protein sequence ID" value="VDM32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6205.A0A0R3X3D4"/>
    <dbReference type="WBParaSite" id="TTAC_0000785201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000785201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000785201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intraciliary retrograde transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein localization to cilium"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
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        <property type="entry name" value="Ift122/121"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="8">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000785201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12446" checksum="43787337A8FEEA40" modified="2016-01-20" version="1">MLSFVWDLCFSPDGKLVVAAVGCNVLVYRAECGTLLKTLKGHRDTCLCVNFSSDGSHFASGGVDNVVIVWRSVTFDGILKYTHNSSIQGVCFNPKMLLLASCSSYDIGTLSLMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Y0</accession>
    <name>A0A0R3X3Y0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein sleepless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8067</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020440">
        <property type="protein sequence ID" value="VDM32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3Y0"/>
    <dbReference type="WBParaSite" id="TTAC_0000808201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000808201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000808201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8188641at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23590">
        <property type="entry name" value="TFP_LU_ECD_Bou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000808201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14260" checksum="F51DBD2B46CE2C21" modified="2016-01-20" version="1">HFTKCLNCYVCNSSVDPGCLDGEFQAHIINADVQPLPCNVRDARFCIKTTTIYGAIMGTTRFCSSESLGDQCQYVDFPDHDRIYQACVFTCENDACNSSRGHCQDLNVLFMFCILIASLMDARLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X572</accession>
    <name>A0A0R3X572_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8581</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020538">
        <property type="protein sequence ID" value="VDM33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X572"/>
    <dbReference type="STRING" id="6205.A0A0R3X572"/>
    <dbReference type="WBParaSite" id="TTAC_0000859601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000859601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000859601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249293at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="426"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000859601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="736" mass="79491" checksum="1DDBBC1D05A6BA62" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X653</accession>
    <name>A0A0R3X653_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020638">
        <property type="protein sequence ID" value="VDM33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X653"/>
    <dbReference type="WBParaSite" id="TTAC_0000897401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000897401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000897401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000897401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6436" checksum="0C0243E936B70712" modified="2016-01-20" version="1">MVEDRGGNFILDDLVPDEYVVSPCHDHLHEIKVIAEGYKGELLRADDLCRAICTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X699</accession>
    <name>A0A0R3X699_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS9009</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020654">
        <property type="protein sequence ID" value="VDM33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X699"/>
    <dbReference type="STRING" id="6205.A0A0R3X699"/>
    <dbReference type="WBParaSite" id="TTAC_0000902401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59863" checksum="D92D41D8C403EE38" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6C0</accession>
    <name>A0A0R3X6C0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine kinase</fullName>
            <ecNumber evidence="10">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9032</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01020659">
        <property type="protein sequence ID" value="VDM33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6C0"/>
    <dbReference type="STRING" id="6205.A0A0R3X6C0"/>
    <dbReference type="WBParaSite" id="TTAC_0000904701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000904701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000904701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="12">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="367"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000904701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63243" checksum="AA80ACD7DA2C8FBB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6W9</accession>
    <name>A0A0R3X6W9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9259</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020737">
        <property type="protein sequence ID" value="VDM34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6W9"/>
    <dbReference type="STRING" id="6205.A0A0R3X6W9"/>
    <dbReference type="WBParaSite" id="TTAC_0000927401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000927401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000927401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000927401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18998" checksum="126F5D0D041725EF" modified="2016-01-20" version="1">MSFLFDPSILQDLGLDAALQAKDITTDPSPGGCQYLLRPLRSTDFDYLRLLKQLTVVGDISESDFECDTYFIVVLEDLPLRKLIGCATLLVELKMIHNRSKRGHIEDVVIDEAYRGKGLGKLLVSVLIEVGKLQGCYKISLDCDSDKVAFYERNGFKQETVSMCVRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X700</accession>
    <name>A0A0R3X700_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9296</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020751">
        <property type="protein sequence ID" value="VDM34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X700"/>
    <dbReference type="STRING" id="6205.A0A0R3X700"/>
    <dbReference type="WBParaSite" id="TTAC_0000931101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000931101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000931101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF1">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000931101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12241" checksum="55A17049299E1B35" modified="2016-01-20" version="1">MQTRSSQFNTVFCCAMVDTVKSSDLLEEALALSKLIRKHRGRIVIYTGAGISTAAAIPDYRGTHGLYRNSTPSSRKVIGTKLRLPEASYAKPTFTHMAICALVTNGYVSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7A4</accession>
    <name>A0A0R3X7A4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9412</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020805">
        <property type="protein sequence ID" value="VDM34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7A4"/>
    <dbReference type="WBParaSite" id="TTAC_0000942701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000942701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000942701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260829at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000942701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39216" checksum="35E3A64E223C05FE" modified="2016-01-20" version="1">MLLAEEETGRRETALTLADRKEVAHLLPPLLSTAQHSCTSTQGRVDFANVRAYLHTFTALLRSFGILVCPSDETISEPVRTKNNESAQENRSPPPFALIHLIIIVLLLFNLLPTTNAFELGQIRQQRNPTLLRPVSPPLFDSERSADGVPTEDSTVKIRTRDVENPPRVALPQVDNSIADPWLYNVPSVDSSVQRPALTPVFVPNYNQYAVYSPLWSYPETRLVGAYGPPPPVPHWPSQPYYSRNSAQFRRRLGERRRKEKYKGEKCPKICDTCLRSYDGTDVDVDKERAILQQRFALHVKPSMKHKESVEALFKYMDGNNDGSISFTELQNYLLLHNIISPDIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7V0</accession>
    <name>A0A0R3X7V0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020925">
        <property type="protein sequence ID" value="VDM34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7V0"/>
    <dbReference type="WBParaSite" id="TTAC_0000962501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000962501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000962501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000962501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="23924" checksum="AA1B16C8DC5B24B7" modified="2016-01-20" version="1">MLLEVGSLTSTTSNLGAKTRTQSKVISLQSPFYETSVGSRAIRYKWDPEGRNDFVGGKVTIRAASSADSEPAKVASVGISDGEVILGGLTPNTLYSVIVTVTRDGKQVHNTWDNIKTLSTKGTHATNRPPDPFYQLAVDTESIRVTWDAKDRKELLGAEITMEAMLMSDPEQTQSASADSSAGAVAVDGLTPNTLYLVTVTVTSSGSEVMHFTKPIKTPSKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8G0</accession>
    <name>A0A0R3X8G0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9820</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021078">
        <property type="protein sequence ID" value="VDM34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8G0"/>
    <dbReference type="STRING" id="6205.A0A0R3X8G0"/>
    <dbReference type="WBParaSite" id="TTAC_0000983501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000983501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000983501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000073">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000983501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18374" checksum="3C2D86C93A9978BA" modified="2016-01-20" version="1">MSGQLPTRIKKETERLQREPVDGIKIAIDDANARYFHVIVEGPKDCPYEDGFFKLQLFLPEDYPMTAPKCLFITKIYHPNIDNLGRICLDILKDKWSPALQIRTVLLSIRALLSAPNPDDPLANDVASQWKTDEAQAIKIAREWTRLYASRSNLGDTSNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X907</accession>
    <name>A0A0R3X907_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021241">
        <property type="protein sequence ID" value="VDM34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X907"/>
    <dbReference type="WBParaSite" id="TTAC_0001003201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001003201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001003201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6238595at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001003201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="820" mass="90993" checksum="F4028C9FB18E0556" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9N8</accession>
    <name>A0A0R3X9N8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS10248</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01021472">
        <property type="protein sequence ID" value="VDM35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9N8"/>
    <dbReference type="STRING" id="6205.A0A0R3X9N8"/>
    <dbReference type="WBParaSite" id="TTAC_0001026301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001026301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001026301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="13">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="12">
        <location>
            <begin position="207"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001026301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="469" mass="53697" checksum="190AB190AB7A6FDA" modified="2016-01-20" version="1">MTIVENQSDDGSVFITLGVCAMAKKTKSKPMKEILRRLEKFQHIKVIVFEERVILKHPIEAWPLCDALISFYSDGFPLQKAIAYAELRRPYLVNDLKAQYVLMDRKKVYECLQMEGIPVPRYACVERGDPSNRVNVIEHDDAIEVNGEIFHKPFVEKPLNAEDHNIYIYFPSSAGGGSQRLFRKVGDRSSKYFQISTIRTEGSYLYEEFMPTDGTDVKVYTVADDYAHAEARKSPALDGKVERDSEGKEIRYPVILTPREKIIAKKVAKVVKQQICGFDLLRANGMSYVCDVNGFSFVKTSRKYYDDCSHVLGVLITRVIAPRLCPPGLGPWNTPGPDDDIPLVPTTCGTIMELRCVIAVFRHGDRTPKQKMKMDVRDDRFFKLFNKYAGGRTLELKLKKPTQLQEVLDIVRNILEDIESGKLKNSELEEKKAKFEQLRYVLLYLSHSHFGNGGRERARERLILLIKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Y9</accession>
    <name>A0A0R3X9Y9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovate family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10349</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021583">
        <property type="protein sequence ID" value="VDM35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Y9"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Y9"/>
    <dbReference type="WBParaSite" id="TTAC_0001036601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001036601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001036601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5394539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001036601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22796" checksum="92FD41522ED758FD" modified="2016-01-20" version="1">MNRISQLLVSRFSLARRSHRCYRFVPSKPVWRWHDDRSPCSDSSVFSIPPEEIPPRIKLDDQTLKLLERLSLVNFNKEMFNTFKFVILLSVPSRPPQTTKAIVEEAIHFADCLLTPTAFRNGNTRATVQPMFSLLGEEGWEPVENMEEEEKEDIDSISITATHILRHAPVAWENYFVAPPGNRPIHPELNVRAESSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAW1</accession>
    <name>A0A0R3XAW1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10671</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022027">
        <property type="protein sequence ID" value="VDM35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAW1"/>
    <dbReference type="STRING" id="6205.A0A0R3XAW1"/>
    <dbReference type="WBParaSite" id="TTAC_0001068801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001068801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001068801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001068801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="22429" checksum="0B6873AA3FAA0EE8" modified="2016-01-20" version="1">MVKRVSLAQGDERGHMWPTANGDVAPSVGESNSCRTASHSSSAAPSEPTESGDDEDILGLISSSLDRFNAQLHHNPHVNISIPVNQYGNRPTTPSNDITVGISSDISDPVMPAWAPFAVSAVTNYQQQSSQGQEVPGSLTYSELSLASSTNPMGLFSGSSDASSAVLQRTSMPSPPGLSTLSHQQQPSSGNNSERKQRSLSQTFPDSDETSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB31</accession>
    <name>A0A0R3XB31_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10741</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022167">
        <property type="protein sequence ID" value="VDM35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB31"/>
    <dbReference type="STRING" id="6205.A0A0R3XB31"/>
    <dbReference type="WBParaSite" id="TTAC_0001075801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001075801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001075801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286076at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001075801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15981" checksum="03681527F02237C6" modified="2016-01-20" version="1">MASTVSTPHRSSLSLAYSLNHSRGDLKGERKVKAPRLRDWNRPTRTISVSTIPPIDSGAWQRLTRFQRRFYEWLVFISIQNLKTVEEFWVLKMCEGPQTSGNVDQVLIRKLILDSTGIVSNNVPRLYLSYFLDNVAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC50</accession>
    <name>A0A0R3XC50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11110</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022984">
        <property type="protein sequence ID" value="VDM36090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC50"/>
    <dbReference type="STRING" id="6205.A0A0R3XC50"/>
    <dbReference type="WBParaSite" id="TTAC_0001112701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001112701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001112701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="116"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001112701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26316" checksum="10148C3A2B4EE21F" modified="2016-01-20" version="1">MFALVNGVASSLTIFQACASFYVGAVLLSQDKTTVLAVFRTYSAYSFGSQALGRVASLAPEFRKASHNVKLVFATLDRKTKSDANEGEFLKEAFDGRIEFRNIYFRYPTRPNTRILQRFSHTVEANQSVALVGQSGCGKSTLLQLVQRFYDVSEHGPESGIFINGRDMRTLAPNWIRRQIGVVSQEPNLFDLSIRDNIAYGDNSRVVSMEEIIAAAKEANANSFIETLPEVSSCDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCJ2</accession>
    <name>A0A0R3XCJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11253</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023386">
        <property type="protein sequence ID" value="VDM36233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001126901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001126901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001126901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001126901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="64" mass="6167" checksum="78317AF719026E11" modified="2016-01-20" version="1">MKVSVSNCVAPLHVAVVDAVLSGIGEVAPDEVGEGLTSSAVAATEASRQDGVRGGGEGEASNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD15</accession>
    <name>A0A0R3XD15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024120">
        <property type="protein sequence ID" value="VDM36445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD15"/>
    <dbReference type="WBParaSite" id="TTAC_0001144201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001144201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001144201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001144201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8536" checksum="7AED353236F7E46B" modified="2016-01-20" version="1">MHYAHGDVILLTNRDVMTNRCLREPSTPFPSASLGHLTFALPYQAIRPDLNLTIALIGDASQVCGFHLTISLTMMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDI5</accession>
    <name>A0A158RDI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo repeat-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS685</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000077">
        <property type="protein sequence ID" value="VDM16832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDI5"/>
    <dbReference type="STRING" id="6205.A0A158RDI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000068401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000068401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000068401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270416at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000068401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="794" mass="87727" checksum="E7221C834050124E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RES8</accession>
    <name>A0A158RES8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7992</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01020429">
        <property type="protein sequence ID" value="VDM32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RES8"/>
    <dbReference type="STRING" id="6205.A0A158RES8"/>
    <dbReference type="WBParaSite" id="TTAC_0000800701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000800701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000800701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="164"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="428"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="542"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine methyl ester" evidence="8">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000800701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="74745" checksum="A1337EA31CA13A1E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REU8</accession>
    <name>A0A158REU8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">One cut domain family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8113</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020449">
        <property type="protein sequence ID" value="VDM32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REU8"/>
    <dbReference type="STRING" id="6205.A0A158REU8"/>
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        <property type="protein sequence ID" value="TTAC_0000812801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000812801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="15">
        <location>
            <begin position="609"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="724"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="726"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="776"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000812801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="840" mass="90810" checksum="2FED30808B00268C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF69</accession>
    <name>A0A158RF69_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stabilizer of axonemal microtubules 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020668">
        <property type="protein sequence ID" value="VDM33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF69"/>
    <dbReference type="STRING" id="6205.A0A158RF69"/>
    <dbReference type="WBParaSite" id="TTAC_0000907501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000907501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000907501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05217">
        <property type="entry name" value="SAXO1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000907501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48074" checksum="2CC439FC7FD0E5E8" modified="2016-06-08" version="1">MSEYSANYRPHCFDLRKAFVPEAGLLCPDEPLSDQTTHRIDYKPQPLSPLWRHEKEGYKPPLAPLDNTTNYRLDYTPKQACPVELCPPPSVCSCPGKFDGSPTYRSDYRPWDLPPLEHRKDKSYKPPDTPFEGLPTYRTDYVPKCEARRANFKPKSELVVPNSPLDTVTNYRLDYVPHPLQLRPPKERELPIKSKVPFNGLTTVQSDYTPKKSCLQQSFKPLDNLPDTKDPMSHSTTHRVDYTPHPLCLPYKHPRKEYKKPEGSMEKGTTYRTDYPVLPLCKSEPIMMLECLKCPQPFDGTTVYGTEFKHWNVQKQVIKPVHLYCPPAVPMETLSTTQVDFGPKLACKVELLKPATEPLRSGPFDGQTNYRIEYTPKSVECHCPAAYLSKNKVSPDGYSFEATDPCGHEHYKLLKNQIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EC29</accession>
    <name>A0A3P7EC29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001181">
        <property type="protein sequence ID" value="VDM20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EC29"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="169" mass="17834" checksum="E5F0028064FCA7DF" modified="2019-02-13" version="1">MDTGNSRLLVADAATGRVKSVLAGNEALRGQAATGMAVGARGLWVVNWRANELMLLDLQSNECGRTARSRSVIIVYPEAAWRGAIADSSSRLTTTGESVIATGEGEPNLGVVAGELGVSMMRQARRQPYTLEVEPALRRLAGLTALPDTSPFLVAVDLGGQSAHCLRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EF05</accession>
    <name>A0A3P7EF05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001600">
        <property type="protein sequence ID" value="VDM21341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EF05"/>
    <dbReference type="OrthoDB" id="10044468at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="225" mass="25580" checksum="9E9CB45CF4289DC1" modified="2019-02-13" version="1">MKLHLVVLQSVTTPYSGHFYKDTPSLSSPAVVDSSSYWETRINRALGELCHASTGYQRVASIRRLPTLSNSDYNGRALTFEVILYSTGHGKTLANLEELIKHRLDEAYLSGLGPLDPEVSYVQRLEESMPDPEPDFKQHQDVYYNEKEIKEEYKDDEIVDVAETVKDPPQQDYPGSNRRCPITVRQTAHELAVQNSWRHREILNQPGVIAGKANVEWGCLDRTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EM43</accession>
    <name>A0A3P7EM43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001340">
        <property type="protein sequence ID" value="VDM20796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EM43"/>
    <dbReference type="OrthoDB" id="6254539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="208" mass="24053" checksum="B6B023AB96BCC8FA" modified="2019-02-13" version="1">MLVKCQQVTIEELKNELNSVQCESRKKILQLQQEIESSITKADSALITQLYAEVDHLRKEVSRLESILNTNLDQHLTDLREADRMSTAFRPDNSSHHNLIKALEERLLDYKCNAEKTKQELASLRDRFLKETHIRYDLSRELVQQRAVAQRLSQKLQALHIANEENKENSKTFHENRDTDSLEVLGNAEQDKPSIGSSDLQKVECKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EN28</accession>
    <name>A0A3P7EN28_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000257">
        <property type="protein sequence ID" value="VDM17797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EN28"/>
    <dbReference type="OrthoDB" id="6242738at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="95814" checksum="E38F0D0083EC60B1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EN30</accession>
    <name>A0A3P7EN30_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000237">
        <property type="protein sequence ID" value="VDM17709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EN30"/>
    <dbReference type="OrthoDB" id="6426227at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052429">
        <property type="entry name" value="BAH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048924">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505">
        <property type="entry name" value="PHD FINGER TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505:SF24">
        <property type="entry name" value="PROTEIN WINGED EYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21744">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="247"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="437" mass="47883" checksum="579AF21E4FE1D253" modified="2019-02-13" version="1">MDQVEKVESPPPVRLAPSASNSGVGSSGSASLFTTSVKRRRLGEVRLHAWQVLQQAVLEVVPVSISQLPPGTRVCAAWSDTLATNLYPGVISELGPEKPLPADNCLCIDFDDGDHREVPLHHIRMLPDHFANLTELGRAAGASVSCTANTNTIEARRGQTSPQPSPVSPKGKKMTSVTRRSCPINGATSSPKDPSSIACDDWLNDWPTDEEKVKTPLRVIWKPHGRLRKRYNGMPCYRSLKRNRDGLVVRLGDVVKFNSGGSDQAYLGEIKSICAPRHNELSPLVCASWFYCPEEAGEDGKRVANYEGAVFVTDHMDDNEATCIINRVQIARNYAEYRLSRQKKVAELAKETNKQAPPCEDELASTPHDSEGDSSSDEELPTYFIAGKFDPLTGHVLAWDPDLSNELHLRVTSPSPPSQRPSTPPPPPQPPTAPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EPK8</accession>
    <name>A0A3P7EPK8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000459">
        <property type="protein sequence ID" value="VDM18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="85"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="350"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="493"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="600"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="719"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="847"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1317" mass="145149" checksum="445934EECA143DFD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ERF8</accession>
    <name>A0A3P7ERF8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003318">
        <property type="protein sequence ID" value="VDM23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ERF8"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="255" mass="28232" checksum="8542AB42544E6B05" modified="2019-02-13" version="1" fragment="single">MEVIRPLLQLLDMECPALQNFEGLLALTNLASLDHKHRCRMLREGALPKVEHYMFEDHEDLRRAAVECFSNLAQHPAVVVACGGELPAEEAGSVACGSSGSEVVKLLTLYCYDEKDIFLVRAAAGALATMSYDPGILRKITQVSTFPLLSVFIYSVQKIDFDIPVLTVSLIFDFCSFANKVGKWKEKLEALVAHPSPTIQHRTVFLLHNLIVHGGSETARDIVDSHLVELIDYLQHLPDISDTEILPPEAIVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ET11</accession>
    <name>A0A3P7ET11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006542">
        <property type="protein sequence ID" value="VDM26441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ET11"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="139" mass="14988" checksum="7BB75D2B363BC4F9" modified="2019-02-13" version="1">MSRLLESTAAIYAVSSCCGEGRTMSDIRYEINLKRHLVTPQLKCICSTFNDRLCEIVAISASEDVTTWKVLLSAVEKLLERCCDMVQRVSNGLPPRGGVHGAFCVARACFCLLDVCPALGATVVTATARLLAEETKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FC41</accession>
    <name>A0A3P7FC41_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005963">
        <property type="protein sequence ID" value="VDM26077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FC41"/>
    <dbReference type="OrthoDB" id="2115465at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="151" mass="17139" checksum="F0EF90BB1AEE08A7" modified="2019-02-13" version="1">MIAPGLSCSFLVKLVSSDLQDDVCETLRIFYRPEEEPLKVRIFAKREEEYINLTLVPQVVDMGLCLVNSSLSKMVPFNLFSQKRARIFLCPDFDGVFDVSPSEFELVHEMATEAQIKFRPVVSGEFQTTIQVESENRHVGEIMCHGTMCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FC47</accession>
    <name>A0A3P7FC47_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7094</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020345">
        <property type="protein sequence ID" value="VDM31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FC47"/>
    <dbReference type="OrthoDB" id="10055808at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="131" mass="14797" checksum="CCAEBA825EEAA392" modified="2019-02-13" version="1">MRVVYACESPSVQARYYTSTDSLLSSKTVIIVEGRATCKNDEVLTWITNRNLETDEFQVTFSDDHKKLPKGYYSVRFFDDIGYLNLRQPLGGVKPVFTVDVYHPGIWFSPLIHSETVALLAAALTGFVHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FH27</accession>
    <name>A0A3P7FH27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021503">
        <property type="protein sequence ID" value="VDM35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FH27"/>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="430" mass="48019" checksum="959F81B019A66C89" modified="2019-02-13" version="1">MAFSCNFPFGFFQFKPRIMGYVNTFFILSMITTATELIATQNDEIHYRTIRNPDCDNSTSCPKNETKLIQIIARHPNRTIHFLLPGNKPDAPLSIIMLECDTKPNQLHVNWTRFLSRNGSISNSISLNGTQTSYGMIINELASFITVLSTPTQSLNSIYNDWLCSISPIGVQFCTYSDVNDDARLSPIDIQSQCNHMLGKNLIWTLTDNAVGRNPPNFVYTAVNSTDGSDGLGKVVVDISFPTNKSKLAQEDGFSLTPGKGLVFSITIDSVKVPKKGRVALILLPFSQDPLQEYEDFTDSLSRSASGGETLYNLHLDKRQNLPEHRVSGMQEMTPRVSGHTSAFMQWTTTCEVSEDGVAKRHATANPRMQIPKRVQGRYRLSLPVAFYGDAFYQKHNSDQVNTSVGVRLQAVTFGSPHDGFYTATNFVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FI86</accession>
    <name>A0A3P7FI86_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022470">
        <property type="protein sequence ID" value="VDM35880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FI86"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018286374" evidence="1">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="345" mass="38411" checksum="C70E5434D8027B01" modified="2019-02-13" version="1">MSHLLPLHLLLHSIDLSTLHLVPKQEPGTETTAGQRLCSETGVIAQRAHEWRYGAMPSSRDNSFRCCGVSECMECQVRTDPFSWEGSAQRWSRDSSVPSLNTRRFQGKAYAYCCANNKILSVMEQPKLRKGGYLARCQADCSVSNVMSHVDISWEGENRRNSVMREDYLAQHHHLDIIRSDVARRNEIGSHTDQTSSLRATEVERLECNKRCSAARAYNAQRGSTTQKQSEGNKWRKSKALVTSTLAICTIVGEMQKDFEVKLGMSLTGRNSATHRIHAITLANGIATEPFGIASVRPSKPHPSRIATLTAAFAAAAHYDAIDHNNLRRHSALLRPKHCECEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FR87</accession>
    <name>A0A3P7FR87_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01023120">
        <property type="protein sequence ID" value="VDM36153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FR87"/>
    <dbReference type="OrthoDB" id="6246281at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="134" mass="15468" checksum="05CAC96D639E33F1" modified="2019-02-13" version="1">MWTAPELLRQYPNQGDLRGTYKGDIYSFAIVSQEIIYRKGVFYRPDIFEPEVIIIQRVKSSPPFRPLMEVSEEAGRTADLVGLIQSAWAEEPSLRPDFTTIKLSMRKFNESVTFFSLFSHRLHYLIGLNNSGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G2E8</accession>
    <name>A0A3P7G2E8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020911">
        <property type="protein sequence ID" value="VDM34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G2E8"/>
    <dbReference type="OrthoDB" id="6269138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="151" mass="17177" checksum="AE5311E1BD4C3934" modified="2019-02-13" version="1">MGERFASFDIASEGVKSSILPEGFNYVPKSNRKLPQSDASSPSCFRVLEFIPEGKITIQQAVDMIRSYQLEGKTVFQLAEDYDPDKSMVASVCRYFALFERDDSDVWVPPRGSKDTKTLLDTPIYEEDEQIADEGTSRRLRLHVPKFTLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G3U9</accession>
    <name>A0A3P7G3U9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022383">
        <property type="protein sequence ID" value="VDM35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G3U9"/>
    <dbReference type="OrthoDB" id="6275524at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="111" mass="12062" checksum="EEA7B5BCB3841487" modified="2019-02-13" version="1">MCFHLCTPFVGGLCLTILWARLSKAGLLVGYFASVGAALIIRFVLEKESSLENKHIQLIGLGVALASGFLLPVLITLITTKPLSLEAALGVWNCVQEIDNPLIPWPEVFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G9N0</accession>
    <name>A0A3P7G9N0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000371">
        <property type="protein sequence ID" value="VDM18195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G9N0"/>
    <dbReference type="OrthoDB" id="6288662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="341" mass="36360" checksum="886B5F70264B3D62" modified="2019-02-13" version="1">MSGSKLSCVSSTSVASSSVAAAPNTPNTSASHVQRGMGVSYEGLAANPAYINPSSFLPHAFLHHHPYEFYDRYFKNGLQPPPPPPLPPPPPFLLPPSPALAARMMPNIRYSAPPCSQAWMYSGKPSAGGDTCKDDTTSSNIYETPYAAVDVASASKMPNDASSGNDNSGVCFTSYGVINTTYGNDDGCSHANRYAGLGETQAQAQAQNRPLMEWVVKKRTDGTRYITRRPVRNRLTKERGGHRHAEERVGGTTDDDGGGGEMRSKGAITVSNRQHSKGSGCERRRQQEGCTSSNPTGRVGSRAPRGSSGHRHRGTPTQQSQQQQQQQPPASSGGLVSLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GSA7</accession>
    <name>A0A3P7GSA7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS4724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GORASP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005181">
        <property type="protein sequence ID" value="VDM25528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GSA7"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM25528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="291" mass="31056" checksum="79081BA4B1D78AC7" modified="2019-02-13" version="1">MEVNFIFQSEDFFSVVEAHNGQPLRLYVYNSTTDQCREVTLIPNLSWGGDGMLGCEIGFGYLHRIPPPPASEPKVPHIHPPLGSVVAPSGLNSTAIPMNEQLANQQSYQQNMSQQLPLSNQVYPSLPPQCSPTEVTSGPLPHPPPAYPSVESIGGVTLAPPAPLPSNLFEGINFTPPSTPPALVLPSTDCHEVQLETTPPVPMTSPSLLVEAQQQMTPPPPPPQAPLAAMFAPTSQLPVPPQMQSFASVPAPTFSVPLIPTTNVAPPGMPPISVQMPPTDLCMWHTFLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H8D7</accession>
    <name>A0A3P7H8D7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020335">
        <property type="protein sequence ID" value="VDM31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7H8D7"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="7">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="568"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="67479" checksum="44E340F884BDD610" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHU9</accession>
    <name>A0A0R3WHU9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mevalonate kinase</fullName>
            <shortName evidence="10">MK</shortName>
            <ecNumber evidence="10">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS139</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01000009">
        <property type="protein sequence ID" value="VDM15934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHU9"/>
    <dbReference type="STRING" id="6205.A0A0R3WHU9"/>
    <dbReference type="WBParaSite" id="TTAC_0000013801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000013801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000013801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="11">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="12">
        <location>
            <begin position="298"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM15934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000013801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="41494" checksum="7194C7D59572DF8B" modified="2016-01-20" version="1">MVSISASGKVILFGEHAVVYGYPALALSIDASTTLKFRRIIPSDGSDIAFNLNFIGVFDRSICLKNSDFVFDLPSDSEGSDMHSFFLTKSQNLLSQVDGSRHIVQSVAVILFSYHLLHSKYRVRTASPPCDITISSTLPINAGLGSSAAYCSVVAAFFLYLHGCITGPNIADGDLSLVRSLANELEKIMHSSPSGVDTAISISGGMVWFQKDIHDGFTSIRPLPLSLRPTNLLKLLIINTNTPRLTADVVNSVQEFRECNPGLCDQIFENISVICKEAGAIFSAPLDDDSLNVLCKLFVQNHDALCKLGVSNEVLDEIVKRLKTIGFGAKLTGAGRGGCAIALPSKTADSRNAVDRVKNLLQDMNVTVFETTFCAPGMRIQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHZ2</accession>
    <name>A0A0R3WHZ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS187</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000012">
        <property type="protein sequence ID" value="VDM16044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WHZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000018601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000018601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000018601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78358at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000018601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28695" checksum="E8D1706C6E8CC04C" modified="2016-01-20" version="1">MLRELKSFPHHRKVGPCVTRPPYRDGKRKRAVKVFTIADESMYLLIFGAPSIGLLKPLKERIQQFEEIQQISKVSHPEAEEFTETYLVKFRSVNLARNVKRRLDDSSFYGAFLHIVYAPEYETVAECRVKMHSYRRLNDSEAVAWRTHSMKGRWDSSLNTEKTVVDLGVAEELSTSVSTATVATSEDAVLFGNPYAVPLHMVSASQIKRQMGDALDDARNYWASRGLDFFHNSKHHSLQPTDPSPIPLLTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI35</accession>
    <name>A0A0R3WI35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS234</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI35"/>
    <dbReference type="WBParaSite" id="TTAC_0000023301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15032" checksum="655222CEED6BAF83" modified="2016-01-20" version="1">MPFPGSSRVRSMGSGTRHTTGAFDMENSRRKNASSVSVQHHAHNLSRGAAVRVLEVTTCFILGMTLVVVLVPAWVLDPRSLRKKRFVAGKCGAMEQMCLRTLVSMLVEHLQMCDASPPRGKDVTQMNLVSQSTTVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIG0</accession>
    <name>A0A0R3WIG0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS384</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000032">
        <property type="protein sequence ID" value="VDM16340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000038301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000038301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000038301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272699at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000038301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27977" checksum="A66AB14E4C65A359" modified="2016-01-20" version="1">MRESIELESAKFMEELDHLRDTQGHLVEEVEHVYTEKVNVKTTQTKELRTKELKRVNFAHVKETGHLCDKTATMERDFTGRTVCMERQVDERREVENLNAYLRDIAKVTVDLKPKHLHPFIVEDLKAVQVGMKSQHDLIKDTFTQMQNRHEHVLHQFEENCQNSTKDLVKMIQEENQRMCRLREDLGLCDDLENMWRERVKDDLLGEVEEGLLTTGIRFQLEETITALYATVSLVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIP6</accession>
    <name>A0A0R3WIP6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS485</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000043">
        <property type="protein sequence ID" value="VDM16513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIP6"/>
    <dbReference type="STRING" id="6205.A0A0R3WIP6"/>
    <dbReference type="WBParaSite" id="TTAC_0000048401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000048401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000048401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000172">
        <property type="entry name" value="cyclin-dependent kinase G-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000048401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16210" checksum="12FDD0209E0675C2" modified="2016-01-20" version="1">MEAGIDELKLFGVKKLIPFRIPTQFREGRCRSVSDFEKLNRIGEGTYGIVYRARDSVTGEIVALKKVRMENERDGIPISSLREITLLLSIKHPNVVQLREVVVGRSLDSWISDMVLLILTTSFFLELFMGLAHFLSIGLIWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJS5</accession>
    <name>A0A0R3WJS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubinuclein-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS939</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000134">
        <property type="protein sequence ID" value="VDM17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJS5"/>
    <dbReference type="STRING" id="6205.A0A0R3WJS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000093801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000093801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000093801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68076at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF28">
        <property type="entry name" value="YEMANUCLEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="250"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000093801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="883" mass="96527" checksum="2793C05EC0223145" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJW9</accession>
    <name>A0A0R3WJW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS990</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000149">
        <property type="protein sequence ID" value="VDM17278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJW9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000098901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000098901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000098901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12012">
        <property type="entry name" value="SH3_RIM-BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000023">
        <property type="entry name" value="RIMS-binding protein 2 isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000016">
        <property type="entry name" value="RIMS-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035753">
        <property type="entry name" value="RIM-BP_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000098901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42278" checksum="D2735B74713B2D95" modified="2016-01-20" version="1">MWKVIRLANPCLLTTTGLRRRFQSEVRNQTPDRRPMSSPPLRPTSTADGCVFFVSLYDYDPATMSPNPGAVDDELPFREGDIIKVYGDCDEDGFYFGECNGRKGFVPSNMVCEASADEVTEFLRRCITTSTGMPPGQMTKSHRIVAQRSGPSEQSTGHVSLYSVKPPPENFGYYHYPQHGERAGRDRKVRGEGRRTRLQRSACAEEKQVTVGGVEATSRKRGESQKPQHCVMEALYDYDPHIYSPNVDVETELKFRAGDRILILSEMDEDGFYVGQLESSGRRGLVPSNFLRQLPRVSAEDNASPVNSGASDGGDVYDSRSKMVYGVPGSGPTHGSKSSRSRGASGSRPTLRSDDADLGPVSRRRRSSGRKGEVNETIYSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJZ7</accession>
    <name>A0A0R3WJZ7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1024</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000159">
        <property type="protein sequence ID" value="VDM17326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WJZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000102301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000102301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000102301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="OTU" evidence="12">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="91"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1797"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1806"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM17326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000102301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1865" mass="204557" checksum="58F7EB9FF50A277F" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL63</accession>
    <name>A0A0R3WL63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1486</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000339">
        <property type="protein sequence ID" value="VDM18087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL63"/>
    <dbReference type="WBParaSite" id="TTAC_0000149901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000149901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000149901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6258785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132876" evidence="2">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000149901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34390" checksum="1E09F9D8E0C1FEA8" modified="2016-01-20" version="1">MFVHGFVALFLCAFTFLLKVHSTGCFDLGAEMDNCAQIHRIPRLSDKRHGYDFGYGSLNDTEFMCRTKYHIKIIKCVKERWEATCDTSAEPDFLKVVWAHTLNTKRYERAAAYICRQHNLRIFHQHKDACLREAEPAAEGCSRQTDESIQEVVGALKNQSVNAALGLIGDTYQQHLKKIMLVYECKAMRRKLDCLYALLSSQCPVNAVQLIMNYFIESLPTGCHYLYRSAGKEDTEAMTMAIANPSAMQGDDGTPPRLSPILPLHLNEALQSPSDLPPNHCSCGVGADVVIIFTILIIPWFLVLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL80</accession>
    <name>A0A0R3WL80_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1503</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="UYWX01000347">
        <property type="protein sequence ID" value="VDM18114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL80"/>
    <dbReference type="STRING" id="6205.A0A0R3WL80"/>
    <dbReference type="WBParaSite" id="TTAC_0000151601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000151601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000151601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="42"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000151601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="53907" checksum="230AC7C96CA180D4" modified="2016-01-20" version="1">MEAYWESLAAFSNNSVDYPYLPSIDKPVWILGESRSSLNDQEEIANDIRSRLWFTYRRGFAPIGDEKGPTTDTGWGCMHRCGQMLIGQALIQLRLGRGWRWNPDRLDRPYLQILRMFEDKPTAPYSIHKIASKAALDDNRTVSSWLGPNTVAQVLRKLSAGDRWTNLVVHVTTEDGIVVQEIKSLCHQNAPKIIATDGTTYDKVTSPPSPTSYDSLHSSQLRKNSDRPVIVSSPITVEEDDESVAIILPPVHIMPRNMSSSLLEAKTPVEDDSSPTTETPNPEFLSMPTTTAAASSTWHPLLLILPLRLGLHEFNMRYAPALQGLFKLRQCVGVIGGRPNHALWLIGSVGDDEVLCLDPHTTQAAAILGEPATGSGNEDASLDGSFHCTNPLRLPLRCLDPSLAVAFVCGTEADFDDLCTQLLADQLSSSLFEVHETRPCNIPPPSFTALRTPEGWSELFPTSALTISVPPTLSSKCKTGEPLTPLFLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLB1</accession>
    <name>A0A0R3WLB1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1536</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000365">
        <property type="protein sequence ID" value="VDM18168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLB1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLB1"/>
    <dbReference type="WBParaSite" id="TTAC_0000154901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000154901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000154901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132864" description="guanylate cyclase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="564"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="916"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM18168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000154901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1109" mass="124701" checksum="B0D984C6791BF650" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLT4</accession>
    <name>A0A0R3WLT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1709</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000460">
        <property type="protein sequence ID" value="VDM18426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WLT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000172201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000172201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000172201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17070">
        <property type="entry name" value="DCX2_RP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF11">
        <property type="entry name" value="PROTEIN RPI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="139"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000172201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34573" checksum="C2975756F17E5C89" modified="2016-01-20" version="1">MQHGVSTQPKVVYFYPDGSSYGEGVRVVIHPNRFRTWDSLLEFLTAKFPTLPYGVRSIFSPCGRTQIHEIAELNDEGHYIASDKRRQAKGIQLEDRSVLLPGWKAGRVPSGQKLLNYCLKSQQSKTASADHQTKKQSTRVIYIHQNGNAFHRHRILIEGRAGNSLQNLLQELSFTLCEPVYKIYTLDGKEIHSIEEIFVGPEEYVAVGLEKFRPLSKISVDLSSKQHRPIERVCIQPAPETSPPRSAHSGPVKSRDTSTKGSKNRTLAQSQELKIETKKSNGLQSSQSMFQLSSGRSKSHVFGIQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WND9</accession>
    <name>A0A0R3WND9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2263</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000909">
        <property type="protein sequence ID" value="VDM19433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WND9"/>
    <dbReference type="STRING" id="6205.A0A0R3WND9"/>
    <dbReference type="WBParaSite" id="TTAC_0000227701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000227701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000227701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284623at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000227701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="213" mass="22584" checksum="B7E87503E7C6308B" modified="2016-01-20" version="1">MDILRVSSGMDVLTIGASIPASYPDDPSLIFLASETDVFPAGDLTTMHIQEMETEVNCYWREMPCEDGRTASDETGMGVLGEVLAAGSENKPENLLTCQLARIASCLPIFLTKDNSDIKALCPQGDVRTARIGRPMDAQTYVSTRTSTCTYTRTYKISVRCDHAADLCASPCAAVRGTEGGEEGLKGVKVAVAAATAAAAGGHVLSASHIWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNS9</accession>
    <name>A0A0R3WNS9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">28S ribosomal protein S24, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2404</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001041">
        <property type="protein sequence ID" value="VDM19926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNS9"/>
    <dbReference type="STRING" id="6205.A0A0R3WNS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000241701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000241701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000241701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950413at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM19926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000241701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19544" checksum="9B008EEEB19AC71B" modified="2016-01-20" version="1">MLAPLRKLRCRVEILQLHRNFHTSLYLLKNTRSGVVRRTRNMSEPLTYEQSKKPHQIGVLKSWNSWNTANLHDEDNYTGIITWQDSLIRLFIQGTFPTHILSEIIIRRQANMVHICFNLSNRLSANEIYFLVGYGEQMLSYLLRCPVKIEPRMILNPKDVIFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNT9</accession>
    <name>A0A0R3WNT9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sine oculis-binding protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001051">
        <property type="protein sequence ID" value="VDM19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNT9"/>
    <dbReference type="STRING" id="6205.A0A0R3WNT9"/>
    <dbReference type="WBParaSite" id="TTAC_0000242701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000242701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000242701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10639800at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000242701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="35203" checksum="822C352C45C4CFE7" modified="2016-01-20" version="1">MTASSGVTNNTANGSSCNGNAGNSDSPLTCCNAEEGTKDSLKEKPMTPLSAAKRKRLSPISGHGQQPNGFHSSTSASASPIKQKKSEDSTTLLAPPATVAATNTTSSSTVATGSSMNPRPSATKVPPNVNTGMELPTPLNSGTILSLQPPSTGANRLSVGTAQQIEGITLPVSSAVNCGGNIIICSSAPAATIQHQQQQSASIGTWNCQVKSLDTRSTPLTLVRLPNGQLAAVPSTVFGGSQVTLTAAPPPPPLPPPPPPPPPPPPPQQPVLQSHGATLVLRYPQHHPSLQKTGDQFDPSQGVVDPTTTNLTIVNGNYQFQQTPHFQHQVSSVRKMVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPI6</accession>
    <name>A0A0R3WPI6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2661</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001342">
        <property type="protein sequence ID" value="VDM20810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPI6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPI6"/>
    <dbReference type="WBParaSite" id="TTAC_0000267601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000267601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000267601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM20810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000267601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13444" checksum="13C42446C6B2141F" modified="2016-01-20" version="1">MDMQHIIPTDLRQLRACLLCGLIKTMSQFEMNGCENCEDYLNLQGDRESVYECTSNNFDGMVAMMNPSESWVARWLRIDKLTPGVYAMSVSGKLSKSRIDHLRSRGLEYQSRDRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ32</accession>
    <name>A0A0R3WQ32_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAP30-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2857</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001596">
        <property type="protein sequence ID" value="VDM21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ32"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ32"/>
    <dbReference type="WBParaSite" id="TTAC_0000287201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000287201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000287201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000287201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="358" mass="38816" checksum="034DDCFADC7844DA" modified="2016-01-20" version="1">MSLENSPTFVTSDDENESSLGSQKRKAGNNPDEQKSLDLQPKKRFRSGKGSGINLVSYALDNDDGDSGSESESSELNRGGSSADSYSNNNDSSVISGAFHFVASDGGPLTVLSSAHIEAAHDSPSTLLEELHGGSEDLPQKDQSSHHSSPSNVSGHNQSMEVSLPPEPKELCSMQLQNTVENTLRRMQHDIGFDPNSVIQDNKAFRNPSIYKKLISFLDIDEKGTNFSSDVFNPYRWDANSFYDKLAEIQNREVERLDKLQKERRKAETSSAVAVNTVSGLQRAANGTNIAATSATATHATGLTAVEKRSEVRKRSKWDTVAPAEPSQTSLKVAAPQVVDPIATKVTIPAIGDLFHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQP1</accession>
    <name>A0A0R3WQP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3066</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001877">
        <property type="protein sequence ID" value="VDM21879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQP1"/>
    <dbReference type="STRING" id="6205.A0A0R3WQP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000308101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000308101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000308101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000308101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22069" checksum="C12158FA579F0F76" modified="2016-01-20" version="1">MNIDSATLRQVFDALDNTNRGFITVEQFTSALEKFYTSIAKESTNVEHQSKLARMQSMDVDNIVNALDPEKDGIISYEDFESAFQNFFNCRNREELKGKTMTLNLHGRRVSITPDDFVMQQSEIDPDLKTEDSGFLEPNVGDLTPSRPSTLLTRTSIPSYNENAGSPFSGSRSDLMLDDVDSNLEQLKVSVFTSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRU8</accession>
    <name>A0A0R3WRU8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3A subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3473</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002490">
        <property type="protein sequence ID" value="VDM22701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRU8"/>
    <dbReference type="STRING" id="6205.A0A0R3WRU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000348801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000348801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000348801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000348801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71634" checksum="99649D551687C5A0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS66</accession>
    <name>A0A0R3WS66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3592</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002693">
        <property type="protein sequence ID" value="VDM22933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS66"/>
    <dbReference type="STRING" id="6205.A0A0R3WS66"/>
    <dbReference type="WBParaSite" id="TTAC_0000360601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000360601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000360601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
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        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
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        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EAGCHANNEL"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000360601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11409" checksum="983ABDF0A11E1237" modified="2016-01-20" version="1">MTGYSRVDIMQKSGNCSYLYGEQTTQEMKERLMQALDNQTKEQLEILLYKKNRTPLWLMVYIAPVVNERAETVLMLLTFRDITALKTPIDDDESNKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT74</accession>
    <name>A0A0R3WT74_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G patch domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3948</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003341">
        <property type="protein sequence ID" value="VDM23826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT74"/>
    <dbReference type="STRING" id="6205.A0A0R3WT74"/>
    <dbReference type="WBParaSite" id="TTAC_0000396401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000396401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000396401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10019757at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF9">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000396401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28275" checksum="75B2BC1047BDC705" modified="2016-01-20" version="1">MAPPNGRVCTTDVNWMRAVDDLHPHSDAVRSETKQEDMLNRPSDFAVNQLKKFGWSEGDGLGKNKNGISEPIKASMKFSRRGLGATYQTAEIDGLLWSSVYEKALSPVVVSNTFIWPKVEFVSAAAFQVDESPNCRKRELVTIKPKPQRTHGKSKDVSMSQERRKRKRRECGGVSVKDIGDCVEMGEEKDRGTQAVKKMKCPREATGAKEGVNMRSFLNSLSGTCLLELGNGRTGHPAARFGIRCGGKLARAAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT93</accession>
    <name>A0A0R3WT93_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3966</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003380">
        <property type="protein sequence ID" value="VDM23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT93"/>
    <dbReference type="STRING" id="6205.A0A0R3WT93"/>
    <dbReference type="WBParaSite" id="TTAC_0000398301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000398301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000398301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283447at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000398301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18457" checksum="5DA524CCDC648812" modified="2016-01-20" version="1">MFARQRTNCPSNSSMDIRLSKTRLEVSVNMGNFDVLTVSPARTHLNDGAWHHVRVHRSLTAILAEVDEGGGPGLSAFLPLDPTSNFLKFSIGTKILIGARRDFLPDSPPLASNEVRPSGSSIGDTCFRDLRLNSAWYPLNQAEIKAAGTEGYVSSINGFGDNHDACSGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTD0</accession>
    <name>A0A0R3WTD0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TORC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003462">
        <property type="protein sequence ID" value="VDM23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTD0"/>
    <dbReference type="STRING" id="6205.A0A0R3WTD0"/>
    <dbReference type="WBParaSite" id="TTAC_0000402001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000402001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000402001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000402001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9046" checksum="318E9E28B3876207" modified="2016-01-20" version="1">MCSSIAGEGALDLTELPHEVIDLSHSNPVDLSGAHPHASRSTLWEPEPGFSFTDLLNVDDEDPRGLLLGGEFEVGLDLRLPEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTJ4</accession>
    <name>A0A0R3WTJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4069</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003597">
        <property type="protein sequence ID" value="VDM24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000408401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000408401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000408401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000408401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34615" checksum="7120B61C2662355D" modified="2016-01-20" version="1">MALIPAINANNLDTVKELLQEGTNPNVYEVFGRKTPLIVAAENNCHEVMHELLKHKVSVGHADRWGNTALHYAAGKGYLRCVILLLLHHSPVDVFNRRLHTPLMRAAMKGHEEVVRHLLNNHATFTSQLNEKKETALTLGCRSGNVEVVQLLLDRASPLEDRSAELYYGLREAVALSHAEVVKVLLQHGSDVNHSDDTTSPVIFLAVTSGTVAILNLLIAEGADLEKVNAQGYTPLMKATAMGRKDMVDALLAAGMLLEFQNHSLYMFMLFTGANAKARRRGRSETALTIAKKEGQNDILRLILRALKREEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTR7</accession>
    <name>A0A0R3WTR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003759">
        <property type="protein sequence ID" value="VDM24276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTR7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000415701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000415701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000415701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000415701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35635" checksum="3036CC6932F333A3" modified="2016-01-20" version="1">MPSAKRLSSVAQRLPYLLPGPSAIALSPGRANDWDSIAVAHTDRREVSTWNFVRATRGRHWLDPRRFHGKGGEALRVHRRTIATCLCMTRCGNFVVIGYSSGDVAKFNMQSGLEYGEFGNKGKVHESTVIGVHVTSVNRVLITVGRGEVKFWNFSTCKLIDTLDITSSPRFSKFHDESDTLALALSTGEVMLVNVVNRKIFRRFNNPVTHVCTDLALSSDGTMMVTTHRCDPLIKTWDVVDCKLIDCFRVQRPATSVAFSPADDLLATTHTACLGVYLWDNRATYQRLHLKPLPEDYVPPNTAGFIELPTERLSTRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUB9</accession>
    <name>A0A0R3WUB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS4344</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004192">
        <property type="protein sequence ID" value="VDM24714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUB9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000435901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000435901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000435901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM24714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000435901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22359" checksum="E08C6D0582C76B70" modified="2016-01-20" version="1">MRLEVIPLIVTPSASSVVNGTIRLDGRLRLKVRKSRSEILGNPDVLPDSIPNSKSLVPCNIGNESSSKGFFNAAHGSFRCPAGYICKGYWEGPNFGITSFDNIGYAMLTVFQCITMEGWTDIMYMTFDAVGDRFSAFYFSPLIILGSFFMLNLILGVLSGEFAKEKERVEKRRAFLKLRRQQQTEKEFGGYMDWIQHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUI9</accession>
    <name>A0A0R3WUI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DHC_N1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4413</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004355">
        <property type="protein sequence ID" value="VDM24880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUI9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUI9"/>
    <dbReference type="WBParaSite" id="TTAC_0000442901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000442901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000442901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="1">
        <location>
            <begin position="198"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000442901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36827" checksum="E47506D3B8027315" modified="2016-01-20" version="1">MSLEELDDMRLRFVFDFLQAMTDMKPEKLLKVKEDTVTMDKIFEFFENQEEQLMMIILPPSGQMEVYNKFPAVMKSKGYYFVKAQPASFEKNIDMNQLKSGIIYGDLHKSPIHHFIAFVNSVLAPFILNDKSREDWPESLNDYIKRDLYNLQKKSEFVLAKMEGRTHLAHPVKLDKLAEGQNPVTVKGEDAIGSMLCSIEMTVVDWNKQINECLEQSSETSVPSGQLPLPSHEFDFWNQRTNSLYNIYDQLVHPQVKKMAIILEENGSAYTTLFRNLFKKVVRGVVEAETIVIFLTPLMKYLDELEALSFEECKPNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV24</accession>
    <name>A0A0R3WV24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1624 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4599</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004858">
        <property type="protein sequence ID" value="VDM25255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV24"/>
    <dbReference type="STRING" id="6205.A0A0R3WV24"/>
    <dbReference type="WBParaSite" id="TTAC_0000461401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000461401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000461401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133037" evidence="2">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000461401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35254" checksum="A0A994B992D39894" modified="2016-01-20" version="1">MLGLHFLILFLLRVQSTHSIDCDLCFRPQLLRSTQLPQPYSKAPLKSSNTVQQPVLQSGEMMRLLVNCSCCDKTASIAEHFSTPGALFYRIFTENRYSTIISRQPNVDPVIRSRFESAGDMSTKYDECRNYPLCAVLYTPVTSNNQVTNYLFWVEANLIGRSAIRVELVWINATQREQPDDIPLPSALGEKEIRKLKKNNRITRNKRFNFQVVKQGRVAGTVNTTASHVTVFLKPQLFYTVFDWSVLFVAGTVALSAGCNTNPQAFVRQLKRKPLAIAIGLAIHLFITPLVRNYFHPVQLRWHDCGSKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV30</accession>
    <name>A0A0R3WV30_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4605</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004868">
        <property type="protein sequence ID" value="VDM25266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV30"/>
    <dbReference type="STRING" id="6205.A0A0R3WV30"/>
    <dbReference type="WBParaSite" id="TTAC_0000462001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000462001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000462001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000462001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16072" checksum="D1FFB1E98C87C723" modified="2016-01-20" version="1">MIYLPAATIVSQWFAKLRATATGISMCGSSIGTAVYSAILPKLLKIYSWRGCMAIMAAMSLHCFAAGCLFIPLRDYQRGHPIKKNDKAEKEGEGEDASMKSKSGLSDTRSKRSATPNSGSMAESGYLKRTDAVSCLIEAYLNSLSPHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV91</accession>
    <name>A0A0R3WV91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005008">
        <property type="protein sequence ID" value="VDM25405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV91"/>
    <dbReference type="STRING" id="6205.A0A0R3WV91"/>
    <dbReference type="WBParaSite" id="TTAC_0000468101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000468101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000468101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000468101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39954" checksum="C31424B8C9F0DB05" modified="2016-01-20" version="1">MHIDSPLDSKVKGTMIKDMLNLTGFNLPSTKDVSSGNTRTSAIPLPCGILNINPGIYDSHFTSKQAINPTSNEDSSNKSETLKWMEEIKKPTAPPHPWLLDRRVTMSRLSDDERKKHEYYVLRAYEACLSGLDQTTHTSRHQDPPTQNVIQPRIQLDLESLPPPTTPKESTISTSISQGAGPDSLDLAAFMKLREDHKRAMARRRLEHKQLLHRANIQVLGETEDRWEATKDSNETPVGEKRCEGDNLNLAEEPKSKTTKSPTALEQFRWAVENVLDFITPSDLRCLVQMLDAKNRAGAFQPVFPADNISTTASYLRFFEKPRYPNLLIFAYLDRYGESVEGEFLPYSNEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVG6</accession>
    <name>A0A0R3WVG6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4741</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005213">
        <property type="protein sequence ID" value="VDM25561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVG6"/>
    <dbReference type="STRING" id="6205.A0A0R3WVG6"/>
    <dbReference type="WBParaSite" id="TTAC_0000475601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000475601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000475601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000475601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8140" checksum="A0C0ED989BCDADA1" modified="2016-01-20" version="1">MLSILFDRMRVEGVVDAFQTTKLLWWQRRGLVETSTEYAFCYATALEYLNLYEPLPINQMTTQTPSSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWG9</accession>
    <name>A0A0R3WWG9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS5094</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006235">
        <property type="protein sequence ID" value="VDM26248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WWG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000510901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000510901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000510901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="7">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM26248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000510901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34756" checksum="1DF61FC6958C3477" modified="2016-01-20" version="1">MSQLGCQKRLAAAVLGCGQKKIWLDPNENSTIASANSRKLIRKLYKDNLIIRKPVTVHSRSRARRQLIARRLGRHTGVGKRKGTADARMPQKVLWMRRMRVLRRLLKRYRASHKIDKHLYHHLYQQCKGNIFKNKRILIDHIHKKKSERLRAKQLSDQAEAMRQRKREAKVRREERLVERRKKMLLGAAAAVVQPAAKSVKEQAKGETSKAVAPPKKSEMVKVGTKKVGGLSIDVKRGEASEPEAKTATVAARATGTKAGGKKAEAPKVETKKTESKAGLAPKGEASKPAKGASSLKTSKTPAPPPKLPTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWV7</accession>
    <name>A0A0R3WWV7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Symplekin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5234</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006700">
        <property type="protein sequence ID" value="VDM26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWV7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWV7"/>
    <dbReference type="WBParaSite" id="TTAC_0000524701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000524701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000524701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000524701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10157" checksum="83366169F697896C" modified="2016-01-20" version="1">MQAFLEYCAPAMAGENVARRLLPPLECALNLLAQMPDIVRTFGNHLSAPSALVRLRLYRCLALLPPSAYSSQLPSYGLVRLSFFVLEFSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXH3</accession>
    <name>A0A0R3WXH3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBIQUITIN_CONJUGAT_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5448</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007568">
        <property type="protein sequence ID" value="VDM27020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXH3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000546301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000546301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000546301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM27020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000546301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21079" checksum="3AEBF3E12451944D" modified="2016-01-20" version="1">QEFWDIQQDKLEYCIITIPDPSNIFVWKAQIKGPPNSPYEGGRFTLAIRFPKDFPRNPPTVTFETSIFHPNITNSGEICLDILRNGWTPRVTIAKIILSVLSLMAFPMAENALNPHIALIMENSWMAFETMAREWTTRYAWFADSRPVQSLQPAAANSDKERKSKGSKKSGSDKKSKGSGSSKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXL2</accession>
    <name>A0A0R3WXL2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5486</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007706">
        <property type="protein sequence ID" value="VDM27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXL2"/>
    <dbReference type="WBParaSite" id="TTAC_0000550201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000550201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000550201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133069" evidence="1">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000550201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20223" checksum="F71D0A64349135A0" modified="2016-01-20" version="1">MFVLAVGKGACVLLSPLHVQAAGGNQLTRHTVDTTTVVQWHGKRLQPELRVRTGLSSVVDVTQAFHFVQTQSERRSSAQSSKQHGVRMQHSRLLVVRGCMSHEWCICGYVDEQVEKWMMGERCSPAYMEGASSLTFILLQAYQKRELSQCRGSTVSKQREGWVVDDGEIVCAYKRLPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY11</accession>
    <name>A0A0R3WY11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008330">
        <property type="protein sequence ID" value="VDM27357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY11"/>
    <dbReference type="WBParaSite" id="TTAC_0000565101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000565101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000565101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000565101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13887" checksum="AC9F5B1DEE4BCE39" modified="2016-01-20" version="1">MQFEDVLSFRFSNNCGTVGEPCYGKSNKRIVDRGWIYELDIDASTHIQPPPPPLVELEAPHGHGQWKYACTDFAIRGEARMGQQQSVQLPGGMVNCASTYMLSDSVTCLTLIRLAPEVKRRIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY94</accession>
    <name>A0A0R3WY94_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5717</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01008708">
        <property type="protein sequence ID" value="VDM27516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY94"/>
    <dbReference type="STRING" id="6205.A0A0R3WY94"/>
    <dbReference type="WBParaSite" id="TTAC_0000573401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000573401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000573401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="8">
        <location>
            <begin position="133"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM27516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000573401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24185" checksum="F6FA58C9E0C0C22B" modified="2016-01-20" version="1">MFDECETYRLWRIKKTILKMCHDRGYLVMQKELEQTLDEFKEAVGDPPSRKDLLMVVNHEEDPADMLYVFFPEEDKVNMKTIRAYVDQMQQDHTYKAILVLRDGGLTPAAKTAISEMSHKYTLESFYENELMVNITEHQLVPKHSVLTNEEKKELLDGYRLTESQLPKMQVSDPVARYYGLKRGQVVRINRPSETAGRYITYRIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYU4</accession>
    <name>A0A0R3WYU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5919</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009705">
        <property type="protein sequence ID" value="VDM27961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000593401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000593401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000593401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286647at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000593401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9065" checksum="77D364E3CB79C4A4" modified="2016-01-20" version="1">MASRELIADSAPDSVLAVASLFSTHRPRGGRLGGQKGMRGGRRRRQCTIAYRVRLFPFWRRRFLIKFDRLQLTALFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYZ5</accession>
    <name>A0A0R3WYZ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5970</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01010012">
        <property type="protein sequence ID" value="VDM28085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WYZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000598501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000598501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000598501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM28085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000598501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14005" checksum="B0F127B1335B1CA7" modified="2016-01-20" version="1">MRGGRGGGGVGGGVSSWWRSELVVVGVVLVVLADWRGVSRGLDNGLALTPPMGWLTWQRFRCQTDCEAYPQDCVSEALVVRQAQVLVQDGWLARGYEYVIIDDCWSAYERDPISHRLQADAVRFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ19</accession>
    <name>A0A0R3WZ19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U2 small nuclear ribonucleoprotein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS5994</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01010112">
        <property type="protein sequence ID" value="VDM28136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ19"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ19"/>
    <dbReference type="WBParaSite" id="TTAC_0000600901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000600901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000600901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM28136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000600901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11047" checksum="0C256F8BD52F1AF9" modified="2016-01-20" version="1">MVKLTIDLVEGAMQYTNPLRDRELDLRGYKVPAIENLGSTLDQFDTIDFTDNEIRKLDGFPLLQRLKSLIMTGNKVLRYNRFNRDTTIIRIGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZL9</accession>
    <name>A0A0R3WZL9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prospero domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6237</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZL9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZL9"/>
    <dbReference type="WBParaSite" id="TTAC_0000625201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000625201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000625201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038576at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="7">
        <location>
            <begin position="173"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000625201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37302" checksum="24D0F3B64C09F664" modified="2016-01-20" version="1">MTFFGNVKLLTVSAPDQCTSVESEIAAPSKLSNRLQFCMSPLKAVYVVPPPSLLLNSPMLMQAGMPLRSWIEGGSRSLTWNQELEAGQGDDFCSKTLELSMQQIENRLSENGIGKASIWKRQNNVSHKEPHAPPKRLDNLLLEEPMNLSFHNAKSVSLMAVPRISALQHILKGEVLNGQHLRKAKLMFLYARYPSSAYLKHFFPEVTFSRYNTAQLIKWFSNFREFFYINIERCARSLVAEGVRSPKIIQVIPKLGLYRTLIFHYNRSMECETPAEFFAVIERALLEFFLAIVTGGDSHSAWKKKIYKTIAQFDQTIPERFRYLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZW9</accession>
    <name>A0A0R3WZW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6357</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZW9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000637201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000637201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000637201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249205at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000637201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39393" checksum="3AEE3E3ED3B06963" modified="2016-01-20" version="1">MERFLVGAGGSTGPKKVSSNSKTFTPWVEKYRPKTVNDVAQQDEAVSALQKCLKGSDLPNLLFYGPPGTGKTSLILALARQLFGPLYSDRVLELNASDERGIGVIREKVKSFSKLAVGSNIEGGSGSISPPPYKLVVLDEADSMTAPAQAALRRLMETDVKSTRFCLTCNYVTRIISPIASRCAKFRFKPLTSDVARSRLRYIADAENVDISDSTLDHLLVLCDGDLRQGINLLQSASCFATPCGQKESNKSVSVTCDDLDQVATVVPDHFEKAFISAAKKHDFDAMQSTVLDLTRESLSVPQFLTQLQARILESTDFPDRSKQKILQVIAEIDLRIVQDAEEYIQLLHLGCQMIRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X066</accession>
    <name>A0A0R3X066_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6475</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020305">
        <property type="protein sequence ID" value="VDM30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X066"/>
    <dbReference type="STRING" id="6205.A0A0R3X066"/>
    <dbReference type="WBParaSite" id="TTAC_0000649001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000649001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000649001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="258"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000649001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38833" checksum="1AF601E0BCA04135" modified="2016-01-20" version="1">MMNFGADRTSDFLQLVNTLRAATSNGHVRTGDPISSMASHHRTSNGISTSSIASKSSQFARMASLISSDLAVTCSRLESLSTLARQRTLFDDHSTEVQHLTLLIREDIANLNHRIADLSNLSKSAITSPQQQSARHATSVLMNLQSRLAGMSERFKRVLEQRSKTLRDQTLRKSAFSAQQQESLTTSGLSNQGFDSQALDSPESSAVPSISPAIMTPSILLQDEQRARQASGIGDNSSSLLVDSSQQQQMALFRDQTDAYLAARHDTVRTIEHTIVELGEIFQQLATMVHEHEERVERIDANVEESVAAVESGHAELLRYLRSVSSNRWLMFKVFGVLLLFFLFFVVFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X091</accession>
    <name>A0A0R3X091_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6511</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020306">
        <property type="protein sequence ID" value="VDM30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X091"/>
    <dbReference type="WBParaSite" id="TTAC_0000652601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000652601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000652601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962932at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007747">
        <property type="entry name" value="Menin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693:SF3">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05053">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1322"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1539"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1327"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000652601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1570" mass="172812" checksum="EA9C38C0598D1802" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X109</accession>
    <name>A0A0R3X109_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent helicase ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS6839</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020326">
        <property type="protein sequence ID" value="VDM31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X109"/>
    <dbReference type="WBParaSite" id="TTAC_0000685401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000685401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000685401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041430">
        <property type="entry name" value="ADD_ATRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17981">
        <property type="entry name" value="ADD_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="103"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
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</entry>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="WBParaSite" id="TTAC_0000714201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000714201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000714201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000714201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35957" checksum="FB81714BFB23E37F" modified="2016-01-20" version="1">MADLPSTQLASTRRPHTCTHPQLHDICIVTRLRLRLRLHPTNGAPRPRKADPPSAFPYTLSPSFPPSYLPHLFATHFISSTNTTTAKWSHVHTQRGLLCQTNCMTTVTKHFGERRKGDCGSSEPHVIRLPNSVLTDSLFHSTTHTTMSVKCARRSNTASLKADTSLVVRATCSAIDELHSTPFPPPTSPSPHVALRLHLIQSAVGVIQPPLSSVWSSLLPLHLPLHLYRLGRHDHHHPVIIIIIIRDDTWKASLLRHCIPSSLPLILHLPPHSSSSLTCLISSSVLLPIPSLSRAAPHQFIHPCHLEVQHLWQCWRMSSEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2E1</accession>
    <name>A0A0R3X2E1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum lectin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ER lectin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7437</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020373">
        <property type="protein sequence ID" value="VDM31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2E1"/>
    <dbReference type="STRING" id="6205.A0A0R3X2E1"/>
    <dbReference type="WBParaSite" id="TTAC_0000745201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000745201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000745201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133138" description="Endoplasmic reticulum lectin 1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="64"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000745201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40605" checksum="2399CFDB5E8872A8" modified="2016-06-08" version="2">MYLFTAVICAILFAFNTSGDFDISDEYTYSMIWDASSNSQVSSRKVQEGVLHPSVLLADFFKAYPCIFKVEGFWTYELCHDKHIRQFRAEGAGPKLTRIVKEFYLGRISGSKEKSIQINGRDFFYYSVEYDDGTECDLTGAPRRASVLYVCLEESDGELFQVSELETCVYQLIVFTRHLCASPRYNVLVSFYFKSHKVYSNPITCVPHDENTSRKPRALISLEKEKEELIALGVSDMKVLNELHLDQRRELQSFLDGETCLTGGAGWWRHEVCYGGRITQYHESGERTEIVLGKWDEAAHLHWIKQNSLREYKQNISYLSFCPLPSKLTQFYDNGDFCEEIKAPRSVRLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2J2</accession>
    <name>A0A0R3X2J2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7494</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020377">
        <property type="protein sequence ID" value="VDM31884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2J2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2J2"/>
    <dbReference type="WBParaSite" id="TTAC_0000750901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000750901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000750901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001472">
        <property type="entry name" value="Forkhead domain protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF388">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000750901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34641" checksum="53CF09CF46A5CE06" modified="2016-01-20" version="1">MDTANSESICYDSSALSMDLFRRLTSYIQSQQHQQQQQQQEQLNPSIPMDQLASTALALKKRIDDFASSVASATTASTSTNTNTSTATESGANTPVDENDFPTDTLHKPPYSYIALIAMAIKSTPEKKITLNGIYNFIMEHFPYYRYHRQGWQNSIRHNLSLNDCFVKLGRDKSHPGKGNYWTVTTGADDMFEHGNYRRRKRRSRLPAQKLEESKKRCHPGGRQIADSITPATLATPTPYPVFIPISIPIPPPLGFQPPSLQQTSPLLQQQPSQLPLSTESVSTSRTPISTSSQSSDRTGSNFSIASLIGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2N1</accession>
    <name>A0A0R3X2N1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5726 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7543</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020381">
        <property type="protein sequence ID" value="VDM31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2N1"/>
    <dbReference type="STRING" id="6205.A0A0R3X2N1"/>
    <dbReference type="WBParaSite" id="TTAC_0000755801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000755801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000755801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6153983at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043784">
        <property type="entry name" value="DUF5726"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18996">
        <property type="entry name" value="DUF5726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5726" evidence="1">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000755801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26763" checksum="618F7BFDEA2F14BA" modified="2016-01-20" version="1">MPNKSSATNFLLKSENLGPESRQAVTTLVAASVDIPPFKEGTDFDDWLFFAKADLELYEPARRVPLLVRALPYDLRREAMDAGVSLSSDMEDCCKVLVKLYLSGIHRLQKPEGDLVQLYRPIPPPGTHRKFYHPWSKEPYRVIKALPPTNYIVRNAEIATRHQTAHHNKIRPYTGPPPVGYEDEVYAVPEKEVPAVSRLCSCTFFNIPLNGSEPCNTLLNTFIVQFRPAKTKIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3F8</accession>
    <name>A0A0R3X3F8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7865</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020414">
        <property type="protein sequence ID" value="VDM32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3F8"/>
    <dbReference type="WBParaSite" id="TTAC_0000788001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000788001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000788001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000788001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11495" checksum="94064969B32E57A5" modified="2016-01-20" version="1">MSQPVVQKDHELKVAFITILWTKEEFDPSIDDMLVGLEDLGFCQRSVVDVPTVVHNSLYDISLRRPSLNTALEGLLSQISREATAIMLVLVNYPVCCSSSPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4F5</accession>
    <name>A0A0R3X4F5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8278</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020476">
        <property type="protein sequence ID" value="VDM32801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4F5"/>
    <dbReference type="STRING" id="6205.A0A0R3X4F5"/>
    <dbReference type="WBParaSite" id="TTAC_0000829301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000829301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000829301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="480"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000829301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="725" mass="80117" checksum="E217720631884159" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5K4</accession>
    <name>A0A0R3X5K4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS8739</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020574">
        <property type="protein sequence ID" value="VDM33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5K4"/>
    <dbReference type="STRING" id="6205.A0A0R3X5K4"/>
    <dbReference type="WBParaSite" id="TTAC_0000875401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000875401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000875401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="240"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000875401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="542" mass="59775" checksum="CD297964368EE02B" modified="2016-01-20" version="1"> </sequence>
</entry>
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        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
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        <name evidence="2" type="ORF">TTAC_LOCUS8829</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM33487.1"/>
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        <property type="gene ID" value="TTAC_0000884401"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000884401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="712" mass="79379" checksum="A08F9F8E0CACEFA7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6H5</accession>
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        <submittedName>
            <fullName evidence="10">Delta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9093</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="VDM33809.1"/>
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        <property type="gene ID" value="TTAC_0000910801"/>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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            <end position="801"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000910801-mRNA-1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6T0</accession>
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        <submittedName>
            <fullName evidence="10">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">TTAC_LOCUS9216</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
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        </source>
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    <sequence length="684" mass="74128" checksum="3749F357FC8496E7" modified="2016-01-20" version="1"> </sequence>
</entry>
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        <submittedName>
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        <name evidence="3" type="ORF">TTAC_LOCUS9536</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
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    </dbReference>
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        <property type="entry name" value="HILLARIN"/>
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    </dbReference>
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            <begin position="111"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000955101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="633" mass="70386" checksum="3D7C1F712DC1EE4D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7M9</accession>
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        <submittedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TTAC_LOCUS9539</name>
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    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OrthoDB" id="6240218at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="VDM34384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000955401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10024" checksum="2F8597DBC3F41B42" modified="2016-01-20" version="1">MGSSFQKVASGVRIILENEFGDRQELLDSSDDADLRADAVPSSICDRDSKKFRESVLASWLKTASDRRKKLQTLMDEYNELVTAVKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7N3</accession>
    <name>A0A0R3X7N3_HYDTA</name>
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        <submittedName>
            <fullName evidence="17">Cadherin</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS9543</name>
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    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="VDM34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000955801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000955801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000123">
        <property type="entry name" value="Protocadherin beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherin"/>
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    </dbReference>
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        <property type="entry name" value="CADHERIN"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000955801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="121676" checksum="43926A10D70253CF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7P8</accession>
    <name>A0A0R3X7P8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020889">
        <property type="protein sequence ID" value="VDM34405.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7P8"/>
    <dbReference type="WBParaSite" id="TTAC_0000957301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000957301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000957301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000957301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15268" checksum="D89EC01E7270ED4C" modified="2016-01-20" version="1">MCEVVLSEHRWMEIWHFAAAAATVITVCESGGRQLDCGGDNDDGDADIVGLSKAMNEMWTGVTASGFLLDKQRCVRGREGGSASLLLRCKEEFAALAKLVLRRSPFGKGRGPMTARLICSQECIQIVECVCTRPDIVDGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7R1</accession>
    <name>A0A0R3X7R1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9571</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020894">
        <property type="protein sequence ID" value="VDM34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7R1"/>
    <dbReference type="WBParaSite" id="TTAC_0000958601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000958601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000958601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000958601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35319" checksum="278B1F5ED9CC4821" modified="2016-01-20" version="1">MNKSEEKPLLTAKRILNRPSAALTFQLAMQLRESTRDNDSNLTQALKRLVHVHSPLLKRDHVLFSLSLSLSLVTLGQAESNVEQEIGIVIWSMDDGLREEWEHQSCGGIAEGPRCCRSGLVMLRPSASRLRHLHLKGGRQVMIRHRRRGLAGTRTSSSSSVSLGTLRLSISNTSGTTSSLISDSSDVVFLLCSRILHNRCGGKDRIRCDGEEEAQTDEGVGHCQRLFFSPSFSSSTFFHPTTSTADLAIRCQRGERRMKPLNNALRSVSLNVVCIKFYSVEEYEEEAAAGGKKTRKEMPSGDIARRGVVLCRDVSSPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7X8</accession>
    <name>A0A0R3X7X8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division control protein 45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9638</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020951">
        <property type="protein sequence ID" value="VDM34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7X8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7X8"/>
    <dbReference type="WBParaSite" id="TTAC_0000965301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000965301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000965301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000965301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="538" mass="62316" checksum="492DC07A916BA9EF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X935</accession>
    <name>A0A0R3X935_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021266">
        <property type="protein sequence ID" value="VDM35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X935"/>
    <dbReference type="WBParaSite" id="TTAC_0001006001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001006001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001006001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001006001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18685" checksum="434ACB456FAC3AE9" modified="2016-01-20" version="1">MATSEHFDRFPIFKEDESTPSTNASSVGNWVNELGLFFHYLLKGLRSNPVHKNYGVTNMQKPLLNLKTEPPYDNHPNISFAVLTTRAKAKSYLEEVVAAVVVMLVTEAEAEAEEEEEEEEKVEDDDEEEEGEEEDEGEEEEEEEEKSSYTSTSVSANCRTSAEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9C0</accession>
    <name>A0A0R3X9C0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021340">
        <property type="protein sequence ID" value="VDM35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9C0"/>
    <dbReference type="WBParaSite" id="TTAC_0001014501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001014501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001014501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001014501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12725" checksum="78FD03687FAA5626" modified="2016-01-20" version="1">MQCTLLTSSSSLQSAIRSGKDSRMSGRGDRRVGPPTGIGGSISAWTDTLVLMASADDESMSVRDTRLNPHFAIETEAAPTSPSSEVSSRECLEASLSDALNKLLSQRRQYLSDDGGEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9D3</accession>
    <name>A0A0R3X9D3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lectin_legB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10143</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021353">
        <property type="protein sequence ID" value="VDM35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9D3"/>
    <dbReference type="WBParaSite" id="TTAC_0001015801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001015801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001015801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6281811at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001015801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18300" checksum="4F1E937F27814FFB" modified="2016-01-20" version="1">MEQISIQTSSLVGGFIGQAHLTNQRVKTLGVKATSLPCLIRGVKCAHDLYTSFLTSFMTVDGVSTLPSVHFLPLLDNVTYARLNITTVSPDLNGEAVAMSNQFSLWIIIVMSLTCLFTIAFILCGLFKRADAYHMPLTPEGEIDIANIEGLGLQGNEGMFGVSGTATGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA49</accession>
    <name>A0A0R3XA49_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10409</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021666">
        <property type="protein sequence ID" value="VDM35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA49"/>
    <dbReference type="STRING" id="6205.A0A0R3XA49"/>
    <dbReference type="WBParaSite" id="TTAC_0001042601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11618" checksum="8C225132B4495FA5" modified="2016-01-20" version="1">MYYSCEICGNQTYRGPKAFQRHFSEWRHAHGMRCLGIPNTAHFAHVTKIEEALALWQRIRTTKEAERWRPDVEEEMEDHAGNVVSRKTYEDLKRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA74</accession>
    <name>A0A0R3XA74_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PINc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10434</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021695">
        <property type="protein sequence ID" value="VDM35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA74"/>
    <dbReference type="WBParaSite" id="TTAC_0001045101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001045101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001045101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001045101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7766" checksum="F745BA6717174F22" modified="2016-01-20" version="1">MPNRSSETNSLLKSEIQGSEGRRAALTLVAASVGIPLFKEDTDFDDCLFFTKADLELYEPARRVPYDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAB8</accession>
    <name>A0A0R3XAB8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vimentin-type intermediate filament-associated coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10478</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021747">
        <property type="protein sequence ID" value="VDM35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAB8"/>
    <dbReference type="WBParaSite" id="TTAC_0001049501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001049501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001049501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6413631at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001049501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25061" checksum="A410FEB4A590B1C3" modified="2016-01-20" version="1">MWVFGNGSGSAHKSSIEEANKHLAAMAEKIEELEKTNEALKQEILEKDERATLCIKQLNDNHHTEVAELNSKIKDHLSTIRTLQSDVKRRDTELNILRQRARMLDEVMRYKASLAKLTITLEQAEQYSRSVAGRAGLNDPRLAVNGSTGSSSLTVYTEPSPRINPSGSDVPPYYLVDEMPDEELIDRVGEAYINGERKKAIGDASSAKHNGKPTLMEKARAKEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAL1</accession>
    <name>A0A0R3XAL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">39S ribosomal protein L20, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10572</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021880">
        <property type="protein sequence ID" value="VDM35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAL1"/>
    <dbReference type="STRING" id="6205.A0A0R3XAL1"/>
    <dbReference type="WBParaSite" id="TTAC_0001058801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001058801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001058801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001058801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21276" checksum="9E1B5602817A6E50" modified="2016-01-20" version="1">MPVGLACRLRCYRLAFRCLHTTVALPKNNSQRYRVHSSPGNTSCKATSRRESVANLRAASSRARWEAEGVAEAKVKGLRPPPTFNVFFAERFERKRWPLRDAVAMLREAAAPEMFNCLENALYAKVTLNQRTKKANKFISKLETSTTLPHQLDFLPKRRIIVLTNVRTAAAFLILSPLIRHPLLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAM8</accession>
    <name>A0A0R3XAM8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="12">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="12">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS10588</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="12"/>
    <dbReference type="EC" id="2.7.7.50" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01021906">
        <property type="protein sequence ID" value="VDM35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAM8"/>
    <dbReference type="STRING" id="6205.A0A0R3XAM8"/>
    <dbReference type="WBParaSite" id="TTAC_0001060501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001060501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001060501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017074">
        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036958">
        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="17">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="18">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="13">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="14">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="426"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="543"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="616"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001060501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="690" mass="78182" checksum="4509367A3A202052" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCN7</accession>
    <name>A0A0R3XCN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11297</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023527">
        <property type="protein sequence ID" value="VDM36277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCN7"/>
    <dbReference type="STRING" id="6205.A0A0R3XCN7"/>
    <dbReference type="WBParaSite" id="TTAC_0001131401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001131401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001131401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001131401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36459" checksum="3EE29FACD219FDB8" modified="2016-01-20" version="1">LPGVKTVPVPLISLDSIDRARSRRKTRVVSTSSSTGVNPSREPKRGLKIDQGRPEPHLIKTPSKTYSRCVNIMTANPNATPWSTGPPDSPFRGQKSSWIQSKMKKNWQILEQPLKSSVSNEVSKSFSAGTVTVEVSEKSELTSSHSMEKKIIATSGNNDDSPVSKPQNSRSLTKSRSQSSSHTPSFYGEVWRPKLFRQTPKRSKSSASEVMENANPSKASVEVSLTHTPTLPSPIKDSFQLSRYHKKENSSNSSPKSDEDGENCADNSPTPCEALKLTRDGRNPVVYGKWFDFNDDVVTEVSCENFKHVFEGVECAYMLFYKRIGQSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCP3</accession>
    <name>A0A0R3XCP3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAFII55_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023544">
        <property type="protein sequence ID" value="VDM36283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCP3"/>
    <dbReference type="WBParaSite" id="TTAC_0001132001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001132001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001132001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001132001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23546" checksum="ED72ADD998C449DE" modified="2016-01-20" version="1">MVDLSLKSLRPMLELHLQGARLNGTVSKGLNKCRTWATSPISGVACLSVERQKLPSKRIVWLVIENIPVAQEAQSLSFKNADIVRWLDFDHTCPESEPPTLPADEYLHCETLYARLISSPIDQAEQLQHRPRDQVIENFDGPSDEDLSVVAGEVVYLLHECSNTHFMAMKKKVMRDYDKKKVTITSIERAKHISFKLRPHRHNCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCP5</accession>
    <name>A0A0R3XCP5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS11305</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01023563">
        <property type="protein sequence ID" value="VDM36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCP5"/>
    <dbReference type="STRING" id="6205.A0A0R3XCP5"/>
    <dbReference type="WBParaSite" id="TTAC_0001132201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001132201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001132201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="265"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001132201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49730" checksum="EC12AEE8DCC539E5" modified="2016-01-20" version="1">MPLLSVWTGPSLRFDLVFECSTTRARVCRLFFPSHCPAGPVETPVYMPVGTQGTIKGVTVGQLEAIDCRLLLGNAYHLGHRPGPETLILAGGLHAFMSWPRGILTDSGGFQMVSLSKLSSTDEQGTHFCSPHDSSEMLLTPEESVGRIQASIGSDIVMQLDHVLHVKTLGEEVYESTRRSVRWLDRCIEAHKPQLRHQNLFAITQGALYDDLRDECIREMTKRKDEVQGFAVGGLSGGEAKTDFCRIVHQSTSLLPRDRPRYLMGVGFPIDLIVCVALGCDMFDCVYPTRTARFGQALVDWGLIRAPVHYISDLGLWFYLEVNLRLTNYTYDFRPIQSGCPCPACSGNISRSWLHAAFGARQSNAASYVTLHNLTYLLNLMRQIREAILADAFPRFVREFFQRRCRPSKTSSGNSDFHIDVEYEFDEVPSWCVEALKKVNINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD85</accession>
    <name>A0A0R3XD85_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11495</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024493">
        <property type="protein sequence ID" value="VDM36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD85"/>
    <dbReference type="STRING" id="6205.A0A0R3XD85"/>
    <dbReference type="WBParaSite" id="TTAC_0001151201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001151201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001151201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133377" evidence="4">
        <location>
            <begin position="17"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001151201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39853" checksum="8880FC9011424094" modified="2016-01-20" version="1">MHITISLLCIVAPTHSCWFAEFADANTTFLCRIYYAEEFRQLRQLVLPQGEMAFIRSLSRCRNWNAQGGKSGSCFMKTYDERFVVKEVSSIEMKTFHDVRKQYFDYLLSAASVQRLSLLARIFGIFHIDYKNVITGDARRLDVLVMENLFHNRPGITHIYDLKGSLRGRLIAKTDNPTVEVTPPVTTTATASTSVATATTLDASSRGTWDEQATVSRVPVLLDQNFINESLENPIYLRLHSKNALMHCLNMDTQFLADLFIMDYSLLVGMDRRAGQLVVGIIDYLRKFTLNKRLEMFVKQTLTSVQGPMPTIIMPVDYRERLLDQMERNFHLVPDQWYDSLADHREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDH9</accession>
    <name>A0A0R3XDH9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11589</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025357">
        <property type="protein sequence ID" value="VDM37209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="7"/>
            <end position="44"/>
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            <begin position="63"/>
            <end position="91"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37209.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0001160601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15121" checksum="9A692C01E4C5798E" modified="2016-01-20" version="1">MKRFYHHGGDLGGDGRGKEEEEEEEKGREKGGGGDEKEEKKQHPGGDLGGDGGGKEEEEEEEEKGREKGGGGDEKKEKKQVGEEGKTTMKVEEEEEVRWSRASIATLVETAGSLEAVPVRWKIAVKVVHVVHQISVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD77</accession>
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            <fullName evidence="7">Golgi resident protein GCP60</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">TTAC_LOCUS28</name>
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    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="LD35087P"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="17"/>
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            <begin position="175"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000002701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47260" checksum="745BB0D571D0CAE4" modified="2016-06-08" version="1">MLLFLEEGNPKIGNEMRANDFDIACVFYKSNTYTYQAKHGPFSPEKVPDVGIFDFIGKERRAKWQSLGAMSRAEAQDTFVQSLLQICPLFAAHLEATDAMSYQKGTSLESQECNDLPPTAVHGLTRSQIRSALNAQTLHQFRAYAAQYYPDSNAKQEELIAQLQDRHFRQYMIYVSRNPPTPPGGIPSQNLEQPSPNNKPGSDQSPPHPWAEDQSNRLTVPKSTKDGTASSPVSKHRRNGSDLLAHIPDGGNHVAVPQMWTRNDINEFKALLGKDPESVINVGSGELITIRVSVVPSGNSLVWEFATDDYDIGFGLSFEWPADSKIPTSNSAGEDEQTVPTEKPFKAPWSLIQGSSQPPEKGENSSHATIEELIPVYRRTSHMEVYCGSHHYPASGGTYLLKFDNTYSLWRNKILYYRVYCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD86</accession>
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        <submittedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS76</name>
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    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000005">
        <property type="protein sequence ID" value="VDM15797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000007501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000007501"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000007501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123441" checksum="97ED4671A1E8C73E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD87</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">SCA7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS79</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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        </lineage>
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        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000005">
        <property type="protein sequence ID" value="VDM15800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD87"/>
    <dbReference type="WBParaSite" id="TTAC_0000007801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000007801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000007801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273191at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="432"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000007801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="941" mass="101914" checksum="2033AADDA62F3FC7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDA7</accession>
    <name>A0A158RDA7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS248</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000016">
        <property type="protein sequence ID" value="VDM16144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDA7"/>
    <dbReference type="STRING" id="6205.A0A158RDA7"/>
    <dbReference type="WBParaSite" id="TTAC_0000024701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000024701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000024701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000040">
        <property type="entry name" value="Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="49"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="350"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="14">
        <location>
            <begin position="466"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM16144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000024701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="65419" checksum="A4703C5B4A2FBDC5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDQ0</accession>
    <name>A0A158RDQ0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1245</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000232">
        <property type="protein sequence ID" value="VDM17687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDQ0"/>
    <dbReference type="WBParaSite" id="TTAC_0000124401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000124401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000124401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000124401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2057" mass="230875" checksum="E95EA1D54A0525D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDX3</accession>
    <name>A0A158RDX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6235</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020296">
        <property type="protein sequence ID" value="VDM30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDX3"/>
    <dbReference type="STRING" id="6205.A0A158RDX3"/>
    <dbReference type="WBParaSite" id="TTAC_0000625001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000625001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000625001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273988at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000625001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="56064" checksum="446F0DE32AE1E55A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REC3</accession>
    <name>A0A158REC3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Condensin complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7048</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020341">
        <property type="protein sequence ID" value="VDM31355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REC3"/>
    <dbReference type="WBParaSite" id="TTAC_0000706301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000706301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000706301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="778"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1502"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1526"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000706301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1601" mass="178693" checksum="035F26C45F0693E1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REK8</accession>
    <name>A0A158REK8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myotubularin-related protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7498</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REK8"/>
    <dbReference type="WBParaSite" id="TTAC_0000751301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000751301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000751301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
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        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="8">
        <location>
            <begin position="6"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="9">
        <location>
            <begin position="1464"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="2359"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="2527"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="887"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1312"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1715"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2416"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2448"/>
            <end position="2467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2448"/>
            <end position="2459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000751301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2636" mass="290029" checksum="8E79D2CE60D72572" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E441</accession>
    <name>A0A3P7E441_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS1027</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000160">
        <property type="protein sequence ID" value="VDM17330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E441"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM17330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="333" mass="36189" checksum="4D0FFB7C32E24403" modified="2019-02-13" version="1">MSTQPLCFSQQALSLFTCFAKAFVMGGSKKVDQLGFFENFCLSGAAAVIAKTAAAPIERVKLLVQNQGEMLKLGTLDRPYNGVIDCTIRTFKSEGLLPFWRGNLPNCLRYFPTQALNFAFKDKVKAAIKPQKSDPYAVAFTKNVVSGGIAGALSLVFVYSLDYCRTRLASDTKSAKKGAARQYDGMIDVYKKTWKTDGIVGLYRGFVISCIGIMVYRGFYFGLYDTIKPIFLGEDAGVTVSFILGYGVTVSAGLLSYPIDTIRRRMMMTSGAAVKYKGSLDCAVSIIRDEGPMSLMRGAGANILRGVAGAGVLAGFDKFKQLYVSYRLGKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EFY9</accession>
    <name>A0A3P7EFY9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001108">
        <property type="protein sequence ID" value="VDM20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EFY9"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30734" checksum="E2C7BD4ED21F7C7D" modified="2019-02-13" version="1">MASLETLLTTNSHITNSQIDEFLEWYLASGASHPKGNEMLSSIYLAPPQSFSKCFKWTRHAARGKSSATAASGGRKTRRIELETCPSANLPTFSRRASLQVCMGTSLQIHPAADLPFTSKQGGATTSSSRKRKHPESHNMKSSHSDSVPHHPKPSASVGASQPKVVIVNLQPTNFDARADFCLRGEIDRVLTRVCQNLGVEIPTAANDGGVFTPKIVLRSKHTTKSERFPWTILSHPDNEISPFAFDEVTDGKREEGRIANIKKEDEASTDEKPVIKFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ETQ3</accession>
    <name>A0A3P7ETQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007070">
        <property type="protein sequence ID" value="VDM26711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ETQ3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="78" mass="8783" checksum="A1440020341EA278" modified="2019-02-13" version="1">MGRTSGSTKSRRPALSALRSNFAPLPPWRSAKLPLRDFSRLSSQTLAFGERLDSSLKSCSNKRMLRSSKRFSKVRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F2I6</accession>
    <name>A0A3P7F2I6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006785">
        <property type="protein sequence ID" value="VDM26576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F2I6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="53" mass="6278" checksum="FE72A9DAB6AD32A0" modified="2019-02-13" version="1">MSLVEIKRLLEASDYDIDDEELCAIFRRVDANRDGELDDKEFLDLVKYLIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F600</accession>
    <name>A0A3P7F600_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003520">
        <property type="protein sequence ID" value="VDM24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F600"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="223" mass="24364" checksum="42E2298922C8D6CE" modified="2019-02-13" version="1">MSLNFWCLNPAVCMQSLAKNAHSLILASGTLAPLDALVAELGVDFPLRLEAGHVVSRERVFATCVARGPRGGRLCATFEHQNTFAFQDEVGYLLLEACQRVPGGVLCFFPSYSLLDKMSARWELTGLLGKLEKVKCVFTEPRSSDNFDDWVAKFHDTVDSMRSSSPSGMTGALALAVCRGKISEGLDFADDYARLVIAVGIPFPAVKDPQVCCSLTSYRQILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FBP7</accession>
    <name>A0A3P7FBP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006227">
        <property type="protein sequence ID" value="VDM26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FBP7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="143" mass="16099" checksum="0A0F64E314693206" modified="2019-02-13" version="1">MRRDASRQSNWRNEGDLKLLQADDIEDDEVEEENEDESPFLSKTKTLSMHSQPQPHESSILATGSSVDSGAESEGELSNSSISHGQQQSETTDHTALQHSQAFRNPIITWIPHPTDMGCQEAFARTTFCQFQHSHISKSQVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCW4</accession>
    <name>A0A3P7FCW4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007020">
        <property type="protein sequence ID" value="VDM26684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCW4"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="143" mass="15350" checksum="7B77BB954041EC65" modified="2019-02-13" version="1">MHLQTVSSAAAAAAAAVPPTSSVMTTTTAMAVAVAVATGVGGDDARLDVDTTLHMTVCCIGKQVGGEETPTPPSASMRPRKRGARAVGPSGRQVTHRCVLMRMREWVDGETDVWMREWVRDGGCLAHSVEQHPREDSQQRMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FEJ4</accession>
    <name>A0A3P7FEJ4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020890">
        <property type="protein sequence ID" value="VDM34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FEJ4"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="225" mass="26608" checksum="DA0E80281B500773" modified="2019-02-13" version="1">MSNKEDLYVEKLSRLGAYVAESIPKFVQKVEVSHMRELDVFIHPDGIIPVISFLRNNHNTQFGALIDITAMDVPARPFRFEVVYNLLSLRYNSRVRVRTYTDELTPISSICDLYQAANWYEREVWDMYGVFFSDHPDLRRILTDYGFRGHPQRKDFPLSGYTEVMRYDEELRRVVIEPVELAQEYRKFDFKAPWESFAKFRDPEHNTAKIANVEETQKAKELPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FKT8</accession>
    <name>A0A3P7FKT8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripheral subunit-binding (PSBD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024506">
        <property type="protein sequence ID" value="VDM36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FKT8"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="67" mass="6950" checksum="59085B86EAD20515" modified="2019-02-13" version="1">MARRVALERGIDLSTLTGTGSGVDGCFVLADLDKVVVGAPGASSYTDVPLTGMRSAYRFPSWVSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQF2</accession>
    <name>A0A3P7FQF2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020972">
        <property type="protein sequence ID" value="VDM34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQF2"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19669" checksum="86E3933969E470E2" modified="2019-02-13" version="1">MKLDQEGSDRDALHQWVRLLLRFMGSKSRRGAPTDELRDKKALAKVQRHLALLLGYADQAFNIPPYKLRTSTVFHAFISHVADVLDRNPPMGSCILHQTLMVLQVCASPQRYANDCQAPNFTLRLLEPQVRHHWLNTLIIILYKVAVIVFESEITHETLLVVCERDNSQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4E8</accession>
    <name>A0A3P7G4E8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS11069</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022862">
        <property type="protein sequence ID" value="VDM36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="717"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117430" checksum="D405764C90C7481A" modified="2019-02-13" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4L2</accession>
    <name>A0A3P7G4L2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023642">
        <property type="protein sequence ID" value="VDM36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4L2"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="90"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="260" mass="28612" checksum="4B34C1AC4B85EDF1" modified="2019-02-13" version="1">MPSLKSVVRSAARKSNNRSVHGQGWTLSKFMSLKNPGQSAVRKRKPSKKGRQRRSMPKTNTQQAGSESASLPVQSLPQTKPHMDDRNFEHLDLVWAKCRGSPWYPAMVINPAAPTKEYNQNGVPIPVPPESVLNVGSSAAVPFQTGPLRVTDAAMSPNSNTASPSPLPVNANTLPPASPTFLVLFFDGKRTWQWLPYDKLLPLATSTAIDEEKLHEAKRSKLRQSVVKAYGRAIEHYCKVNGRPCPFSDGDTDEVAAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G4X5</accession>
    <name>A0A3P7G4X5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000201">
        <property type="protein sequence ID" value="VDM17572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G4X5"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12412">
        <property type="entry name" value="RRM_DAZL_BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034988">
        <property type="entry name" value="DAZ_BOULE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="643"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="691" mass="70100" checksum="A7EB6F440085C93D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7H7N7</accession>
    <name>A0A3P7H7N7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TTAC_LOCUS6734</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020319">
        <property type="protein sequence ID" value="VDM30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="62"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="258"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1815"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="2174"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1863"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1868"/>
            <end position="1882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VDM30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="2752" mass="305856" checksum="057947B52CC95499" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HCN2</accession>
    <name>A0A3P7HCN2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020388">
        <property type="protein sequence ID" value="VDM32025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HCN2"/>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="310" mass="35166" checksum="F003B644286659DC" modified="2019-02-13" version="1">MRPSFLPTMGSESSEVYSLISRRRFSQMAVLEGQNILVTISGRKNRLRVYYLSWLKSKIMKSEGCDKKNGWVNVGENLHGAVTFKIVKYDNIKFLVIALRDSVEIYAWAPRPYHKFMAFKLFSSLHFRPLLVDLTVEENQRLKVIYGSEAGFHAIDLDTNTVFDLYLCPKPNRGTITPHCIVVLPNTDGLQLLLCYDTVLLIHCQTNVTDVAAEGVYVDTSGKMTKNVVIQWGESPTSVAYIPSSGQLLGWGLRAIEVRSAETGHLDGVFMHKREQRFKFLCERNDKVFFSNTRSGSPQVSMMTLSGIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HFF6</accession>
    <name>A0A3P7HFF6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020680">
        <property type="protein sequence ID" value="VDM33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HFF6"/>
    <dbReference type="OrthoDB" id="6269092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35245" checksum="C0C5D38BA282E2F2" modified="2019-02-13" version="1">MPSTLPVFSFRVKPAAVLHVEQRDRVIFVCPKDEYFILWVSGLTNMLKQNNYFHFASLSLPHLPSSLLFTGGCTFECGHTDFYFSTFLPRGQSLSKLVRSSPKLPGIGARRTYKKYAFDNCSNPSDSGNTVNILYRCSFRDPFNSAAPKGLNLSEMNVWSPQVPDTNRTFAATSSASLPFRRPRLLSVAQVGGPAKRSTGREEGETFTLLINEFAWSTGTPSFQKNRPVYFTAAKSPPSSGVERRIPRDEAICERRSNQQRCFLSVPPKEVVNSEAEAQTQTLSCKLEDAVTIGTALVVNAAAQVSLYVHKAWVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHR7</accession>
    <name>A0A0R3WHR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000007">
        <property type="protein sequence ID" value="VDM15850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000010301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000010301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000010301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277724at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000010301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22954" checksum="6E5ED839D0438233" modified="2016-01-20" version="1">MSSWLRRIVSPLIKPKIIPKASQGKAAGELPSGTNSVSTGTQSETKESQDVVEKYEKRLLAELEKMAKNCRRQNYLDNLQLLNAGISTQNRREENFERLWSRARSRVDRRLAKVKKKHSSTRNSLPTDNSPPSIRHVDTLLLNKNLSDGETLATSDLDTLNDYSWEGIECAADTNSRPISRARKKAKRNNKAVSNLKPRRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHV9</accession>
    <name>A0A0R3WHV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS149</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM15955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000014801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000014801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000014801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268815at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000014801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="32804" checksum="EECD4C9DF9489332" modified="2016-01-20" version="1">MNINLFRWRHLKILPGSQQKLTSPLQQGPRKLPHVARRSLRPPFGTLSSVSERTSKAREESIEGSSVSAEQESGCHRALRCLIFIGLWLGFLAALALTIVGVWTRCRNCLTVGVILAIVCLGVAIHNCLRRGEALPSIPIYLEGDSHLSLDCEALDVSKSEDGLAEVEMQAGREMEGGIASKCSSLNGGIPVLSRTVTAYPEENGGVVKGDEARKSGRTTLDVEAGLAHILRPRRHRESAFAGLTRAIITTLMRAGRGSSGGGGNGGFHHAPRNAWNSNFEGHIGWQSALARPDPFYSTAYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI37</accession>
    <name>A0A0R3WI37_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Septin-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS236</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI37"/>
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        <property type="protein sequence ID" value="TTAC_0000023501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000064">
        <property type="entry name" value="Septin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="218"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="600" mass="67781" checksum="6347603D24BBD9C5" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIQ4</accession>
    <name>A0A0R3WIQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HRDC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS494</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WIQ4"/>
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        <property type="protein sequence ID" value="TTAC_0000049301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000049301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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    </dbReference>
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        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="433"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000049301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="892" mass="99334" checksum="53CA1DB2F20BE3DB" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIR1</accession>
    <name>A0A0R3WIR1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled coil helix coiled coil helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS501</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000045">
        <property type="protein sequence ID" value="VDM16539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIR1"/>
    <dbReference type="STRING" id="6205.A0A0R3WIR1"/>
    <dbReference type="WBParaSite" id="TTAC_0000050001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000050001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000050001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70030at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052632">
        <property type="entry name" value="MICOS_subunit_Mic19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588:SF18">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000050001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21177" checksum="9E2C10B837D2E71E" modified="2016-01-20" version="1">MGSVFGTAASHDVTFSRSDILNFIFFDLSAQVSDDVIDSIRRHQPHRNSSTTSPATSTLTPSPLQMDTKEESPSESSVNTAAIASQCLTLSRDELERKYEALLRKLEERNDKYLKAAEEEYARVVDRLYAKYLSHTPVPCCVDAQKQVMDCYRSNGQRSLNCSKEVESFVRCVAAFRSARMGHPDAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIS8</accession>
    <name>A0A0R3WIS8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellular nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS525</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000049">
        <property type="protein sequence ID" value="VDM16584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIS8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIS8"/>
    <dbReference type="WBParaSite" id="TTAC_0000052401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000052401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000052401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10050052at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000052401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11196" checksum="63BFDD5ECAAEE65B" modified="2016-01-20" version="1">MSDRACFNCGEPGHFARDCQKASDRGGFVGGRGRGGFVRGRGRGGGGFSGGRDPVCYNCGETGHFARECNAPRNQNNSGGRSDIQCYNCQGYGHISRNCPEARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIY9</accession>
    <name>A0A0R3WIY9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS601</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000062">
        <property type="protein sequence ID" value="VDM16724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIY9"/>
    <dbReference type="STRING" id="6205.A0A0R3WIY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000060001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000060001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000060001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000060001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40035" checksum="B1D2BF1A4CD167CB" modified="2016-01-20" version="1">MAQGEVDQDEVGKIPVNEMTSKDYYFDSYAHFGIHEEMLKDETRTVTYRNALLHNKHLVKGKVVLDVGCGTGILCLFAVKAGAKHVIGIECSNIIDHAREVVKANGMLNKITLIKGKVEEVSLPSGIDKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPGGLIMPDRATLYICAIEDRQYKDEKINWWDNVYGFDMSCIRKVALTEPLVDVVDPNQVVTNCSLVKDVDMYTITVEDLTFSAPFQLTCKRNDYIHALVTFFNINFSCCHKYVGFSTGPDERRYTHWKQTVFYLDSGDGDECLTVKKNEEIRGIFSITPNSRNNRDLDISIKLNFVGELSSADKKFNYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJG3</accession>
    <name>A0A0R3WJG3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HATPase_c domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS812</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000103">
        <property type="protein sequence ID" value="VDM17025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJG3"/>
    <dbReference type="STRING" id="6205.A0A0R3WJG3"/>
    <dbReference type="WBParaSite" id="TTAC_0000081101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000081101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000081101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="82"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="716"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
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        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
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        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
            <position position="148"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17025.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000081101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="753" mass="85776" checksum="8531CA8BCA63D667" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJT3</accession>
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        <submittedName>
            <fullName evidence="3">Brix domain-containing protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TTAC_LOCUS949</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM17218.1"/>
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        <property type="gene ID" value="TTAC_0000094801"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of exit from mitosis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MAD2L1BP_domain_sf"/>
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    </dbReference>
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        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
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    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000094801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26371" checksum="B70F7940D00069DC" modified="2016-01-20" version="1">MSFSDLLTGQSVLSSSQKTILMIKFLHFFLYNTGQFPDFRLLSNKDDINSNNTFPLIPVRKLQLSIQSVSLLEKELRSLSQFPIEQFLFILGPNVQKPLRMVLLNFRNCDLTPGDNTGSNKEQKFPVFFRGLMGNPYFNVIFEPTSPTRLHVYFKTSRHFRCDDFLPKLTFNPPIGSIHVLNVLSAEDTMELYPDSSEVPTEEIGARVEELLQTDKEMIWFSCSKVITGC</sequence>
</entry>
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    <accession>A0A0R3WK23</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS1051</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
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            <begin position="116"/>
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        <location>
            <begin position="233"/>
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        </location>
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            <begin position="331"/>
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        </location>
    </feature>
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            <begin position="21"/>
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        </location>
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            <begin position="48"/>
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        </location>
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        </location>
    </feature>
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            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000105001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="399" mass="42779" checksum="608E45FDA0B8C391" modified="2016-01-20" version="1">MGALMTKPRSGDNPPKKIRTRTYSGSSLNKKPNLFKSLSKRKDETVRKSATLQPTRTGDNLQVPPEAVTEPILAAPVSCEIKSSSVALNSQLPKGADEVVTQESTALTEEAISKATDSILKEGEAEPSVTMGKHHTGSEEQTVVEDADGIAQKVAEEVIKGSVEDIMEATEDGGEFSPKHPAEPDLQLSECQCGVEPDEPKPEPINEVVHDYQESEIAEILVNEALNAGVEAEIESKQAPSPIAIENPLPEPIDDEQPGSNVEEQRPLSSDQSSDYVEALQQSQSVSEAFADPNEITDGTKNVEVACLNEESKNDDLKGALLNEDLEADAKTEAITQEETGAPISNGVSNGHDEVLHGDEMSTDENGCLEEVPESDPIAILKTSIGEDVEHNDSTTVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKQ8</accession>
    <name>A0A0R3WKQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5737 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1307</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000255">
        <property type="protein sequence ID" value="VDM17789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000132001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000132001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000132001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6222391at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043798">
        <property type="entry name" value="DUF5737"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19008">
        <property type="entry name" value="DUF5737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5737" evidence="1">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000132001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26904" checksum="EDDBD03469BE6577" modified="2016-01-20" version="1">MLGEARVYSRPSNFTIPWISFGRSRIESGFDYGFAQAEVTDKTCYYLVYRALVEAMDRPASRCFVEMDAKSVRLVEKRWPHEEVHIFTKDIVSYYMFDHGSKFVALCIDANRKEKSGYWFINFDTEKQLTTFCDCLHRLFAMTTDWNVNTRRSITRVCKSYRNASTPETISMIKCWRCGSKMILPNWEPSTETRDSGFVESQYTGSSHGKITPTNQLCRYYPSKRTFRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM19</accession>
    <name>A0A0R3WM19_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MRP-L46 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1793</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000512">
        <property type="protein sequence ID" value="VDM18533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM19"/>
    <dbReference type="STRING" id="6205.A0A0R3WM19"/>
    <dbReference type="WBParaSite" id="TTAC_0000180701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000180701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000180701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194611at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000180701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31180" checksum="EAD2C9FE1F18E820" modified="2016-01-20" version="1">MWKIFAGLCIRRPAVVSLQLSPLQRQLQEFFTEVEIQRSHLSAHEVRHRNDLEHMAKVAREQQEKQESARYQTSADGTATSLLTAKDMELSWEAGAKEFWKELGCTSLPGDMNVPASIEEESGTEAISKTTAWRKLDRILVLLTRQRLGKSFDWGLPVVEVTGTSTLRSAVEDLAKALLPPEAQCMIVGNAPVAMHKYAYRIDEGKEKGQKQGVQMYFLNAYVNKLWHGKNVQAEEGPDGKGGEANFAWTCIEEMGEFVTDKRFLRRLRTFIVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMQ1</accession>
    <name>A0A0R3WMQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2026</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000694">
        <property type="protein sequence ID" value="VDM18766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000203901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000203901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000203901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000203901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15385" checksum="14AD2C62F8084A4D" modified="2016-01-20" version="1">MLHYLEIAEGLGTYGVEFFEICNRRGTDLLLGIDAMGLAVYKPPDKITPKVGFPWSEIRNIAFNDRKFTIKPIDKKSSDLVFLTKNLRSNKKILALCIGNNELYVRRRQPVPIEIQQMRSQALEENAFRELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNF2</accession>
    <name>A0A0R3WNF2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2277</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000920">
        <property type="protein sequence ID" value="VDM19476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNF2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNF2"/>
    <dbReference type="WBParaSite" id="TTAC_0000229001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000229001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000229001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="68"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="248"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000229001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50685" checksum="50BE4029C3B232A1" modified="2016-01-20" version="1">MKDGDQVSEEDNWKASLNLPERDARLKTADVAPSEGCTFDSFCLKRNLLKGIYEKGWEYPSPVQRSSIPVALTRRDIIARAKNGTGKTGAYSIPILDSIDPSLNKIQACILVPTRELALQTSQICIELAKHMDIKTMLIIGGTYLKDDLIRLSQTVHVVVGTPGRLIDLMSRGFVDLSYCKTVVLDEADKLLSEELKNAVEKLLEKVDKNRQLLVYSATYPVVVQSFISKHLKNPFEINLMERLTLRGITEYYAYVQEKYKVHCLNTLFSKLQICQAIIFCSSGQRVELLAKKITQLGYSCFYIHSRMPQQDRNRVFHDFRNGICRTLVCTDLLTRGIDIPTVNVVINFDFPKYAETYLHRIGRSGRFGHLGIAINLVTFHDRYALKNIERELRTEIKPIPKEIDKRLYVAEFQDEANMDEETKTALYHGRVLQQREALNNGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNH2</accession>
    <name>A0A0R3WNH2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Paired box protein Pax-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS2297</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000937">
        <property type="protein sequence ID" value="VDM19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNH2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNH2"/>
    <dbReference type="WBParaSite" id="TTAC_0000231001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000231001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000231001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132910" evidence="13">
        <location>
            <begin position="26"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Paired" evidence="15">
        <location>
            <begin position="38"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="401"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="403"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000231001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="651" mass="71362" checksum="909BCB1DD267518F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNQ7</accession>
    <name>A0A0R3WNQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRANULINS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2382</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001015">
        <property type="protein sequence ID" value="VDM19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNQ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000239501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000239501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000239501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000239501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11842" checksum="02C7A318EC59E676" modified="2016-01-20" version="1">MLPTNPCSYLTTNNIRNDCVQELMKEHPHAKGALADILLCEAMEEAKQVEKAKEKAKLCGTKAEQDLGCVTNDVCVHYESPVCRCPPDTCDLTYGARTKLPQQDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPP4</accession>
    <name>A0A0R3WPP4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2719</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001427">
        <property type="protein sequence ID" value="VDM20978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPP4"/>
    <dbReference type="STRING" id="6205.A0A0R3WPP4"/>
    <dbReference type="WBParaSite" id="TTAC_0000273401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000273401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000273401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="261"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM20978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000273401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="738" mass="83108" checksum="079CAD3C7C68D3D4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQF9</accession>
    <name>A0A0R3WQF9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001770">
        <property type="protein sequence ID" value="VDM21681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQF9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQF9"/>
    <dbReference type="WBParaSite" id="TTAC_0000299901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000299901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000299901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000299901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27723" checksum="C9EEA262657FC5A9" modified="2016-01-20" version="1">MVHFDAIRAPLRSRAKWRATCVWKSDDNDILQHVVDPASKMSSQQTLYNCGIGGIGSSGSGESGFVSCHSYGLLCLPFLAPPSRCKSKSSVDSAPSLNVSGSTSSATMRQRRCRSLDRLDAEIAAQFHSDGEFPNNEDYSGYYLSDEDDLNIELDPAKTTHEEDFLPFLAFDTLKRPIKLLHNTGGLLPDLEFPDSDISSWAPGDVDSLSVVNGHPGKATCNASTQTWFTGVVTSAEFYHGPTCTHEQLQVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS88</accession>
    <name>A0A0R3WS88_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3614</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002739">
        <property type="protein sequence ID" value="VDM22982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS88"/>
    <dbReference type="STRING" id="6205.A0A0R3WS88"/>
    <dbReference type="WBParaSite" id="TTAC_0000362801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000362801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000362801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Receptor L-domain" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Growth factor receptor" evidence="3">
        <location>
            <begin position="170"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000362801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49160" checksum="CC1F857A79664E5B" modified="2016-01-20" version="1">MVNCTFWEGNIILKKQSFEGDAFHNLTKEEESVTFEDLQSGLGSLFEITGILYIGTDNAAPWLRNLTFLSKLRRIGGEVPPGYNSPLNIVHNNYLEYLGLASLIFVGAQRGTIQIVQNPRLCLVDTINWRTLMWTPKSSTANTSVPFPVVIPHRAAKDCVSEGLQCDASVCELSQGCWGPGPENCRACAHWLIQGRGETSRCVLNCSLAEGGYYPVMISKTIDSNITLKIKSCSKCHKECGSVPGACFGPHANHCNYGCAHVKDGNFCRAQCPLGKFPDEDNICQECAAVCTSHPRGLLDSTESSNWSAVCTGSGDWFGHKGCSQCIQVVAATVKNMEHGPKLKCLTPYQPCPTNTFLHLIGGQKGKMSDPKLEISGDISLTHVPIELQAPLGEWLASHQSQSASVSMARVCAPCHPECRGGCSGSSPNQCVQCRNAQFNGICVASCHEGKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM1</accession>
    <name>A0A0R3WSM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3744</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002969">
        <property type="protein sequence ID" value="VDM23268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM1"/>
    <dbReference type="WBParaSite" id="TTAC_0000376101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13186" checksum="98018B643EFA832C" modified="2016-01-20" version="1">MDNDGGDDDDDDDVSAMVALVKHQQQQQQCPLTGSKHASTNTTSGSSSNPYGNVADASTQLTTASAPALNVSEIAPKVVQRAQGAQHAASPQIPPPPPPSPPTISESVRHEVKKPIRRNGPSTDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM5</accession>
    <name>A0A0R3WSM5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transducin/WD40 repeat-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002979">
        <property type="protein sequence ID" value="VDM23283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM5"/>
    <dbReference type="WBParaSite" id="TTAC_0000376501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20227" checksum="C94C439EB3E053D9" modified="2016-01-20" version="1">MLGGVKANTIVEARCHDESGNGYDVWSVSDWWKVGMRGQGNGEKRGVQILLATSVITFSFLPLYSLTPYVHAACGPPSTLLWLSWDNAPPACYWHREGQVVARMTALQTSGSGSAPELSILDRVKLGKMWRRDGRVVKAMDLKSIGDSPPSLITAIGHVAEMEKPKGADLRPLTDDDNSMLLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSX0</accession>
    <name>A0A0R3WSX0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02449 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003142">
        <property type="protein sequence ID" value="VDM23542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000386001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000386001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000386001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000386001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7528" checksum="2BB23D2A45DB5D48" modified="2016-01-20" version="1">MAGENSSLKLAIAQLEREQIDLLRLILHLRDRLKQVSKENVELATRAAQTRAAVETAKSQLATVCESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT21</accession>
    <name>A0A0R3WT21_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIP120 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3896</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003252">
        <property type="protein sequence ID" value="VDM23705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT21"/>
    <dbReference type="STRING" id="6205.A0A0R3WT21"/>
    <dbReference type="WBParaSite" id="TTAC_0000391101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000391101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000391101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000391101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15522" checksum="80FD4030103A3CFF" modified="2016-01-20" version="1">MCSSADIALLPSYESSAAISGSGEFELNPGMSPRQHQHLVNSKLFISAKEKARDLVKLIIPLLRCDHPELRESIICGLSRIQPGAFRDVLEDLHPILRESIDLKQKNVQRRRRRDTLRSSLIRLLALMAQNAVFQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTR0</accession>
    <name>A0A0R3WTR0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4135</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003736">
        <property type="protein sequence ID" value="VDM24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTR0"/>
    <dbReference type="STRING" id="6205.A0A0R3WTR0"/>
    <dbReference type="WBParaSite" id="TTAC_0000415001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000415001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000415001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000203">
        <property type="entry name" value="DiSHevelled related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF25">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000415001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16529" checksum="803D997FB1C24A0D" modified="2016-01-20" version="1">MSLNIITVTLNMDSVNFLGISIVGQSTKSGDDGIYVGSIMKGGAVAQDGRIEPGDMILEVNGISFEDMSNDDAVRTLHLSLQFFFSVHPLKKNGLPVVRSSSLLCLLQLIMCTNLVVNQGHDFTLSLNTIIIYLPITFYVFSPWMYVHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTS7</accession>
    <name>A0A0R3WTS7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS4152</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003787">
        <property type="protein sequence ID" value="VDM24301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTS7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTS7"/>
    <dbReference type="WBParaSite" id="TTAC_0000416701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000416701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000416701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM24301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000416701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8977" checksum="D98293B4A308640C" modified="2016-01-20" version="1">MKELCTFFVGQAGVQAASAVWEMLCLEHGVCRDGTIQYEPTLQEHRELNTVFEELTPHEKYVPRAVLADLEPSVIGMLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTU1</accession>
    <name>A0A0R3WTU1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4166</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003818">
        <property type="protein sequence ID" value="VDM24334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTU1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000418101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000418101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000418101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6151507at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000418101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12025" checksum="4F04B033912770DD" modified="2016-01-20" version="1">MEGDVCASFYRPGETRKAREFIPESKKDEKYWERRRKNNEAAKRSREKRRQNDALMEQEIAELKHQNEALTRENAALLRELAALKLLSRYSLINPNVVPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTY3</accession>
    <name>A0A0R3WTY3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF6</name>
        <name evidence="7" type="ORF">TTAC_LOCUS4207</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003914">
        <property type="protein sequence ID" value="VDM24426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTY3"/>
    <dbReference type="STRING" id="6205.A0A0R3WTY3"/>
    <dbReference type="WBParaSite" id="TTAC_0000422301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000422301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000422301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM24426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000422301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26382" checksum="99D1A52900AB343E" modified="2016-01-20" version="1">MAFRAQFEGHNDIGVFARLTNAYCLVSIGGSEGFYSVFEAELADSIPVVHASIAGIRSVGCLTAGNKHGLLIPHTATDQELAHLNNSLPDSVSCVRIEERLSALGNTVVCNDYVALIHPDLDKETEEIISDVLNVEVFRSVVAGEALVGTYSCLTNHGGLVHPQTSVEELDQLSSLLQLPLAAGSVNRGSSLIGSGLVANDWVAFCGLDTTSTELSLIESVFQLTESNAGDATRPLREAILERSVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU94</accession>
    <name>A0A0R3WU94_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4319</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004144">
        <property type="protein sequence ID" value="VDM24675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU94"/>
    <dbReference type="STRING" id="6205.A0A0R3WU94"/>
    <dbReference type="WBParaSite" id="TTAC_0000433401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000433401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000433401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038545at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000433401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23427" checksum="4950EA84B0F2176B" modified="2016-01-20" version="1">MDERRFLEMRKQIDENNEDVRDFLDNMDQWRLDMERKNAQLRSETKKQDDLPHIRNVLHKKKKKRSNPTTVSTELKATNSCRIKSDDYKSWDSFDVDKALDAIDEREEKGASGESETDEEWEDERRIKLADMEKEQGNESKYEEAIEHYTSAIRLSPENPLFYSNRALALCKLERFASAEADCSTALKIDPNLVKALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUA4</accession>
    <name>A0A0R3WUA4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4330</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004162">
        <property type="protein sequence ID" value="VDM24696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUA4"/>
    <dbReference type="STRING" id="6205.A0A0R3WUA4"/>
    <dbReference type="WBParaSite" id="TTAC_0000434401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000434401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000434401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6056548at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000434401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17579" checksum="1EA4D08428153148" modified="2016-01-20" version="1">MPGSPSEESLEELREVFALFDRDHNGYMSLSELKTMMKQFNRACTSDEAKEIFSNLDKNHDGRIDFREFVSLMQPLLDESKSGDFYFRIAFAFFDKNGDGNITTAELKQLLHNLHLKLTDNEVDEMITEADLDHNGIVSYEEFKNMMGRSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUV7</accession>
    <name>A0A0R3WUV7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glutathione transferase</fullName>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS4532</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="function">
        <text evidence="1">GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01004691">
        <property type="protein sequence ID" value="VDM25130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUV7"/>
    <dbReference type="STRING" id="6205.A0A0R3WUV7"/>
    <dbReference type="WBParaSite" id="TTAC_0000454701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000454701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000454701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000020">
        <property type="entry name" value="Glutathione S-transferase P 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="11">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM25130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000454701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19270" checksum="373E8650582D98FC" modified="2016-01-20" version="1">MLEFIGQPYKERRFQASEVEQWFANKKKLGFDFPNLPYLIDGDKVITQSHVITMYLGKKHGLAGANDDDVIKIAIAEGGIKDLRQGISKIALASDYENLRPGFMPTFFEGLETISKYMGSKNFLIGDKLCYADFVLYENLDVFEIFEPKCLENYPNLKRFKKEFEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUX4</accession>
    <name>A0A0R3WUX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004731">
        <property type="protein sequence ID" value="VDM25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUX4"/>
    <dbReference type="STRING" id="6205.A0A0R3WUX4"/>
    <dbReference type="WBParaSite" id="TTAC_0000456401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000456401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000456401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000456401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11111" checksum="3BF03CADE14B5176" modified="2016-01-20" version="1">MEHCQLNLIELMLSSEIEGDCGEDPTSKNTSTVNFILNLISGRASPPFGTKEPILHHLLRGCLLADDLAKLSIVLHTSVHPNFYTTNLEVVFLTLQMKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV61</accession>
    <name>A0A0R3WV61_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4636</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004939">
        <property type="protein sequence ID" value="VDM25335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV61"/>
    <dbReference type="WBParaSite" id="TTAC_0000465101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000465101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000465101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000465101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28218" checksum="D7362D8B998A6FD7" modified="2016-01-20" version="1">MKVPTPHCHYKSNERCEYGALLRVEKMVALHSLIVFVAFVLASGSSVTEEYDNTPNISATPLGPNSIGVSWDVDEMKGREVSVLLAFAVPLPDSTGNFVKMANVDKGEVTINGLAPSTPYRVKVVGLGNGWIGVDGEEVEEEEEEEEEEEEEEEEEAEEDEEDEEEDYDWRSKSKFSFNQLKASKIYMVKADDDQNWLEKKEGELFIWTTIVETLPQGKLHLSCMHCILHTSTSFASVPLHSSALHVHRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVT4</accession>
    <name>A0A0R3WVT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4856</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005498">
        <property type="protein sequence ID" value="VDM25773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000487401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000487401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000487401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133019" evidence="1">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000487401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18460" checksum="71B452704E23478C" modified="2016-01-20" version="1">MQICQLKCLLVVVTVLAVSTVGHDSLLDSFLGCVVDDLLEYVKKHGKSFYVEAIGTLVPSCSLGFEQTQHDGEETYIISICLNVTNLTIAPPIQVAKKVRIGKAKVDGSFQITKGNATKISVKLSAPVFEGAFVYLYFLPVPALPFKERLLSALTELIESQLQSLVSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW80</accession>
    <name>A0A0R3WW80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005937">
        <property type="protein sequence ID" value="VDM26056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW80"/>
    <dbReference type="STRING" id="6205.A0A0R3WW80"/>
    <dbReference type="WBParaSite" id="TTAC_0000502001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000502001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000502001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018185at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000502001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9015" checksum="70154C68246A5CE4" modified="2016-01-20" version="1">MEWGVDGVDGMKDSRTKGFLVAHSITLVPASGEGADGVEQVCVADRERAQIDCYDLNGRRLVQYGGSIFKPSVYAISFSPVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWK2</accession>
    <name>A0A0R3WWK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5125</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006321">
        <property type="protein sequence ID" value="VDM26316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000514201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000514201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000514201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000514201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10482" checksum="0E3F0CB1B96AC65C" modified="2016-01-20" version="1">MTSTSENGEGRGRPIFISTSATHTMTPVPAGGLYSSSSSSASMLAASEGSKTSLDGRRKRPATNLTTPRQSSKLSLSDLTSLPFLLNLINSIVRQTPTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWK6</accession>
    <name>A0A0R3WWK6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5131</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006341">
        <property type="protein sequence ID" value="VDM26330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWK6"/>
    <dbReference type="WBParaSite" id="TTAC_0000514601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000514601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000514601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285106at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000514601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9617" checksum="D3B3BA8FCD5EAA71" modified="2016-01-20" version="1">MADFDASQNRGISMINYTSTSTFFIARWSNVRLKHCSEREFGIFYLLPDFPVGEFSFSVCLFENGSIVFAYDKVRFEYVRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWQ4</accession>
    <name>A0A0R3WWQ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5179</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006489">
        <property type="protein sequence ID" value="VDM26411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWQ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000519401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000519401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000519401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246789at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000519401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32978" checksum="853FE12003607A34" modified="2016-01-20" version="1">MLIMKSSIDQNAEISRLVNIFTDDFSISIPRGVLVESSHFFKAALQSGMSESRSGEFFLSEFSPRQLQHLQHFLSDNDLFTSKVEPLQGEGGESISSDCQMEEQVRRLVEAAFIADYLQMPRFKSKLQTLFQYLIQSLSHPQSPCFSRLHDCNTFTEMVPILSDNRLKCLKKPLLRFIYRYPTVLLDSKFVRFDASQPFLITSVLQTLSSDKIFLYNEDAILNSACEWVEHSLTPPKRRRSGDDNVTEILLSLIQSLRLGLLSPLGLQHLVNLLDGYPQHVAFDATLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX92</accession>
    <name>A0A0R3WX92_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007205">
        <property type="protein sequence ID" value="VDM26812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX92"/>
    <dbReference type="STRING" id="6205.A0A0R3WX92"/>
    <dbReference type="WBParaSite" id="TTAC_0000538201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000538201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000538201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000538201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13370" checksum="65000DA17165E97A" modified="2016-01-20" version="1">MRAHTVPVPPQALPEMTLLRGHTSPTRVADKSAFLALQSTVRNCIPVVLPTSKGPLDLASEVFGSTSAALKSLQRVSSDENIAASFRFKKVHLKTVTPEQIRRWETNFTFLLNDPGNCLWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX97</accession>
    <name>A0A0R3WX97_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5372</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007215">
        <property type="protein sequence ID" value="VDM26821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX97"/>
    <dbReference type="WBParaSite" id="TTAC_0000538701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000538701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000538701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6232708at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000538701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18301" checksum="0564017322F86F37" modified="2016-01-20" version="1">MHLQLTIVHRERNVVFVYTSDNNYVLRVKEYITKVTDIPVSVQKLSFGGVELKNNTKLKEYHLPVNAGILLNLSQGYALRYQVYVKVSFRKNPIRVRIGLGTTLKQVIQSLSSSLQVPAEQLLLSYNDRLLTEKDAKKALIDLGIKSDEVLDLTVVDMWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXD4</accession>
    <name>A0A0R3WXD4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS5409</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007396">
        <property type="protein sequence ID" value="VDM26921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXD4"/>
    <dbReference type="STRING" id="6205.A0A0R3WXD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000542401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000542401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000542401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM26921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000542401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13678" checksum="E2545936B636F873" modified="2016-01-20" version="1">MEIYCERVRDLLNPYGKSNLRVREHPVYGPYVEDLSRCAVQSFDEINEMIEAGNMSRTVAATNMNETSSRSHAVLTLLVTQREIDAQTQLVAEKVSFSHLQDFVFITVCRCFISSNLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXH5</accession>
    <name>A0A0R3WXH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5449</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007570">
        <property type="protein sequence ID" value="VDM27021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXH5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000546501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000546501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000546501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000546501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39033" checksum="21C29B30BD089B10" modified="2016-01-20" version="1">MSSDEGVRKNLIKAAHLTNPDVGSKQSSSPRHKLVASEQSRSENSESVSRRRRRQSSSSRSTSPIVTKRFKNIRSEDGTLVSKEYSRRWSRRSSSRSVSPSTSPKEVKMSAASDGSSMDKSAAAARDVNIFGKTGGAYIPPARLRQMQAKITDKSSEAYQRIAWEALKKSIHGLINKVNVSNIAQVVRQLLSENIVRGRGLLVKSLITSQMASPTFTHIFAALIAVVNTKFPQVGELLLNRLVNEFRKAFRRNQKDRCLTTARFLAHLVNQKVAHELIVLELLTLLLEQTTDDSVEVSVAVLKECGAFLSRAAPKALAGIFEHLRRILNESQCDKRIAYMIEVLFQVSITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXI0</accession>
    <name>A0A0R3WXI0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5455</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007604">
        <property type="protein sequence ID" value="VDM27032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXI0"/>
    <dbReference type="STRING" id="6205.A0A0R3WXI0"/>
    <dbReference type="WBParaSite" id="TTAC_0000547001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000547001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000547001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="2">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000547001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20693" checksum="026D5A7BECD95C06" modified="2016-01-20" version="1">RSSNAEFCDHLSRWAFKESGVLRVANVSHHRVGESTARHEYTITDEIVYKIDIVEKAANGVWHDYVAEDIQLELVRIDPFIRRNLQFGGRFFTFMRMKLPDVYGVFKLVVDYHRIGYTSVFSATQISVRPFTHTQYERFITSAYPYYASAISMMLGVFLFSFVYLYLKESKPKSKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXQ1</accession>
    <name>A0A0R3WXQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DPPIV_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5526</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007843">
        <property type="protein sequence ID" value="VDM27158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WXQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000554101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000554101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000554101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000554101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15883" checksum="1B0E028889414C22" modified="2016-01-20" version="1">MLFYVCSSPRVVLFQLGFRKRTEHTQPDTEDTLYEYDGFYGASKRLSASLTPITASRDNESSHWSANGAFLTSIQSLGTNYPNNYGLRSNRLTALVWRAAPDIVRIGLFDLDRWYHAQMPSSIRYVRPITHGPTSYRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY24</accession>
    <name>A0A0R3WY24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008396">
        <property type="protein sequence ID" value="VDM27387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY24"/>
    <dbReference type="STRING" id="6205.A0A0R3WY24"/>
    <dbReference type="WBParaSite" id="TTAC_0000566401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000566401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000566401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000566401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16204" checksum="326457060FDE90EB" modified="2016-01-20" version="1">MANSDNVVRAGLTPKFKDVDRLLEMLDYNSAVSSPADSLQFCATQSTPTPEGVSMKSFIPPVSEFAVDMIQFDDESRGFSLPQVPTASILLVLQGQGVISCTIAGGTASQELKFGPGFVYFVSADMIVNLISKADRRGSLLAFRAYVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZA7</accession>
    <name>A0A0R3WZA7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS6098</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZA7"/>
    <dbReference type="STRING" id="6205.A0A0R3WZA7"/>
    <dbReference type="WBParaSite" id="TTAC_0000611301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000611301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000611301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="161"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM30246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000611301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="846" mass="93943" checksum="81DEA1BB291FEB30" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZQ3</accession>
    <name>A0A0R3WZQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C-SKI_SMAD_bind domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS6276</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WZQ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000629101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000629101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000629101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF26">
        <property type="entry name" value="CORL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="1103"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="1197"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM30462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000629101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1605" mass="173732" checksum="30CF64CC42BD3741" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZS9</accession>
    <name>A0A0R3WZS9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6306</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020298">
        <property type="protein sequence ID" value="VDM30493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZS9"/>
    <dbReference type="STRING" id="6205.A0A0R3WZS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000632101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000632101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000632101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000632101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60508" checksum="AECD76473869D0EE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZW6</accession>
    <name>A0A0R3WZW6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6354</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZW6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZW6"/>
    <dbReference type="WBParaSite" id="TTAC_0000636901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000636901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000636901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000636901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31355" checksum="1C23BFA2FD3EA1BC" modified="2016-01-20" version="1">MGVQFRSMGTLKDVAMQLKSITSIQKITSSMKMVASAKFSKAERELRLAVPYGISVANFYDRTGIVAQLKEDHSPVKSHLVIAITSDRGLCGAVNSTIGKLLREMLSHPPAGEEIKLVLIGDKARAFLARQFSEHFLMSFTEVGKRPPTFEDASLIAQALLDCDFKFDKATLFYNKFKTVVSYTPVDQPIFSLEQLQHAPSLALYDSVDDEALRSYNEFLLSSLIFYALKEASASEHSSRMTAMQSATNNASEMIDELTLALNRTRQAVITKELIEIISGAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZX6</accession>
    <name>A0A0R3WZX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000638201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000638201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000638201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000638201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35220" checksum="B26A11A0E2844396" modified="2016-01-20" version="1">MMELKLKTHRKFMIVDFRDSNGHADLWTASKSNKTFQEYYLSQLEYSLCHVDLKPDKSTGAIEIFYRSDPCRRHRLLSDGGYIGIKVKISAKGIAAQGLTAGLSFESEISFHKLTIRYSDSKLGVGLLLFSDLSLSPAGDFLETTRLVQPPSPSKREGAKFLIPDGAFTTLLESSLNRTPVLFHASSLAHLKPGEKSSTPVLVLAGPRFPILKSKQRHRLRHSLAKALYGEAFSQQFQKSRHGGWSKSPIGIRMQHFSFSVPGQQMADNTAWSVTLTMEGKEKPEVLAATQSNQSTQALYHWGLFLLKWLSSFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0Y6</accession>
    <name>A0A0R3X0Y6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020324">
        <property type="protein sequence ID" value="VDM31082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0Y6"/>
    <dbReference type="WBParaSite" id="TTAC_0000682701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000682701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000682701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000682701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26357" checksum="474D8C5F81A96302" modified="2016-01-20" version="1">MHTHYCGDLRTHVRTRTRAHARVRSAINVIPLSLSPSLRASLRLWLSLSLSTLSLRLCCLAAHSLASRFIYGSVTAFPLSKSAFRLHSRRYDLGLPRQTTQPHSWKSPLCVFSAFCSTSSVSHYTLKCILPLFMSFLSPFSLWVDVGLCVRLLLCVRVHKFYYWGSFIVLLAYACTFTHTHTHPHTFKHTQAGVPSSRPRLQTHTNTYTRISMRRHQTSHHHYSPSTCACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1K1</accession>
    <name>A0A0R3X1K1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7076</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020343">
        <property type="protein sequence ID" value="VDM31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1K1"/>
    <dbReference type="WBParaSite" id="TTAC_0000709101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000709101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000709101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6222233at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000709101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25395" checksum="B123C08421302CF5" modified="2016-01-20" version="1">MSSTFKPHETETCSKLVDGSMQPVGAVRNFILKRRSIIESYGGEIFGIGVEDTTPLRGFWSSQTTLIILSFDDVKGANDLFQILHLKTEFPQHVEYFTVNLSYPTKHVKDYPLIEISFYDVRYVQRFNWFIYQLPELACKHNGYLVAGTPKIIQKLGMSQPNYCSITQWKTVQEFKYFREQGRSMSKKPQLLAICLFEQSQSACLTEALVKLDVGTCGPFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2P5</accession>
    <name>A0A0R3X2P5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase 25 family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7562</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020383">
        <property type="protein sequence ID" value="VDM31961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2P5"/>
    <dbReference type="STRING" id="6205.A0A0R3X2P5"/>
    <dbReference type="WBParaSite" id="TTAC_0000757701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000757701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000757701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133210" evidence="4">
        <location>
            <begin position="25"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="352"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000757701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="613" mass="71491" checksum="E0945B0EB70FEC4A" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Y9</accession>
    <name>A0A0R3X2Y9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7669</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020393">
        <property type="protein sequence ID" value="VDM32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Y9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Y9"/>
    <dbReference type="WBParaSite" id="TTAC_0000768401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000768401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000768401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000768401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="645" mass="73287" checksum="4C1EC86054D52C1C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3D6</accession>
    <name>A0A0R3X3D6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7839</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020410">
        <property type="protein sequence ID" value="VDM32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3D6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3D6"/>
    <dbReference type="WBParaSite" id="TTAC_0000785401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000785401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000785401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253823at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000785401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65797" checksum="4540177D17D9CD89" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3L6</accession>
    <name>A0A0R3X3L6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7934</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020423">
        <property type="protein sequence ID" value="VDM32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3L6"/>
    <dbReference type="STRING" id="6205.A0A0R3X3L6"/>
    <dbReference type="WBParaSite" id="TTAC_0000794901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000794901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000794901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000794901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10607" checksum="63A4132CB0DF1774" modified="2016-01-20" version="1">MGDVRAFANPRNQVKPPDKGSFPLDHMGVCKAMRDKWVACMKNHDWDSGKCRPESAAYLRCRMANNLMSPEEIAKLGFSNAEWNQAELIYCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3V0</accession>
    <name>A0A0R3X3V0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8031</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020434">
        <property type="protein sequence ID" value="VDM32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3V0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3V0"/>
    <dbReference type="WBParaSite" id="TTAC_0000804601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000804601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000804601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5837785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF497">
        <property type="entry name" value="PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="432"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000804601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="666" mass="74355" checksum="03936ADD1FD5CF43" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X476</accession>
    <name>A0A0R3X476_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020459">
        <property type="protein sequence ID" value="VDM32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X476"/>
    <dbReference type="WBParaSite" id="TTAC_0000819801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000819801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000819801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000819801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12682" checksum="3B8419AE472BAB4E" modified="2016-01-20" version="1">MGQNDREAEGRVSDSGVHYEESHFAPELTFLVKNDKQTELGRLKQPFLLGVSKAQLCERRGCGKGTALDSLDCLSLAQVPPRRDIVGNPASASASASASFLRARASPANKVIGKKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4C7</accession>
    <name>A0A0R3X4C7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8243</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01020471">
        <property type="protein sequence ID" value="VDM32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4C7"/>
    <dbReference type="STRING" id="6205.A0A0R3X4C7"/>
    <dbReference type="WBParaSite" id="TTAC_0000825801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000825801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000825801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="10">
        <location>
            <begin position="43"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000825801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="70510" checksum="27C57AC0266737BE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I0</accession>
    <name>A0A0R3X4I0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020481">
        <property type="protein sequence ID" value="VDM32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I0"/>
    <dbReference type="WBParaSite" id="TTAC_0000831901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000831901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000831901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000831901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12721" checksum="FF98BB628CF6C071" modified="2016-01-20" version="1">MTDANGTAACDDVERERYNAKKATETQTSALLTHIPVTSVDMPRRKDSVDEATFSTHRTSHTLVLLLLPSNSSPTKSRYATVEESIARHQLQHKLTVMATVECRVIVGWHICSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4K6</accession>
    <name>A0A0R3X4K6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1907 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8335</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020486">
        <property type="protein sequence ID" value="VDM32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4K6"/>
    <dbReference type="WBParaSite" id="TTAC_0000835001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000835001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000835001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000835001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21828" checksum="71311CE5404D3A22" modified="2016-01-20" version="1">LSTEITFSTRGLQCNRSLIGFYSKECGSPTSERASNTLLSSVGQIFITEAMPGKVIEIVAHKRIGGPSIFDLIQASLYDKFSKQDLPMALGCVFYLQNSGVQASVLCELPQEPYHTFPCLKKYQASFTIDGPIIGVGTVLSHDPKKMGFSMSTFNCWNASRLLTGQFENDVCPEKATYTVYLTPAKKLYRQDKPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4L3</accession>
    <name>A0A0R3X4L3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8342</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020487">
        <property type="protein sequence ID" value="VDM32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4L3"/>
    <dbReference type="WBParaSite" id="TTAC_0000835701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000835701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000835701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000835701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10952" checksum="33D37CE31DE2818D" modified="2016-01-20" version="1">MRPCREPTRERAPRPPTRELASWRMEQPSVNERPRPVQGTRPRPHGPRAGHAESAPASPTATVRRIAGTTSGTESHLGGLRGEQPDPPPEPLAVTIAHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4R6</accession>
    <name>A0A0R3X4R6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8403</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020499">
        <property type="protein sequence ID" value="VDM32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4R6"/>
    <dbReference type="WBParaSite" id="TTAC_0000841801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000841801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000841801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000841801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="30015" checksum="4B5B83978994ED75" modified="2016-01-20" version="1">MNYLSFIKWADGYVCRKLLLRPKDVDREEELEAVQYHERKEQIYDRLSISEFPAEVQGPVKCLIRRLCNCKCLSAGRMVRYKCELPVLLTSAPTTLHLEVASNVPSFRDQWNPFFRNADGTAADIYERFIGVGERGDAIRLNEYDCIVFFVEFPTSKYLRCKHLKDLGNAITPTQTFIVTGRYPELYGIIAEVTWEQKIFQLLRRFNFPPFVNFTDNWRIWYNRNDNMGKINYVEIIRWACLDVIWRRARALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5C7</accession>
    <name>A0A0R3X5C7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PNP_UDP_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8648</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020555">
        <property type="protein sequence ID" value="VDM33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5C7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5C7"/>
    <dbReference type="WBParaSite" id="TTAC_0000866301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000866301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000866301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000866301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35878" checksum="6DD0C1458167F5DD" modified="2016-01-20" version="1">MHRGVNICNPYVPSMGVDVLYHVGLATDTTDLKKQFGDVKFVIMGGSPKRMKKIAEILLKELDIQLPCGTGLANIACTTDRYEMYKVGPILSVSHGMGIPSISILLHEMAKLLYHAGCQDVRFIRLGTCGGIGLEPGSVVITTSCLDCAFNDYFQLVRFASFVFFVGSHLLHFLTVMSILLQKILGKTVRRPAHLDEHFVKELIETARSMKLDFNVVSGKTMCADDFYEEQGRLDGAICEYTEEEKMAFLKKAYDSGVRNLEMESLGFAAFCQHLKIKAAVICVTLVNRLVSDQISTPVDVLHAWQERPLEILINYIKKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5J1</accession>
    <name>A0A0R3X5J1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8724</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020570">
        <property type="protein sequence ID" value="VDM33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5J1"/>
    <dbReference type="STRING" id="6205.A0A0R3X5J1"/>
    <dbReference type="WBParaSite" id="TTAC_0000873901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000873901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000873901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000004">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000873901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17941" checksum="89131FF4174A29E4" modified="2016-01-20" version="1">MIFLEFHNSAVEDLLLTRFSSAKAGSKFEKIDHTVADFDRILYRIHNPEKDKSKLLVSLLVNFFDELKEYDVEGLLRREYGPYILDEPYPGYSVTLCFDLQNVPDNYEAVARHVAMLKRNCFAAVFEPFFLLQALADEPIISKRAVIHYSPDEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5P3</accession>
    <name>A0A0R3X5P3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">Adenylosuccinate lyase</fullName>
            <shortName evidence="13">ASL</shortName>
            <ecNumber evidence="7 13">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8785</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="7 13"/>
    <dbReference type="EMBL" id="UYWX01020587">
        <property type="protein sequence ID" value="VDM33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5P3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5P3"/>
    <dbReference type="WBParaSite" id="TTAC_0000880001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000880001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000880001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="14">
        <location>
            <begin position="379"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000880001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55065" checksum="98FADDAD0A62913A" modified="2016-01-20" version="1">MSTSMLYLLRYNSLRSPLNTRYASQAMQYNFSPKRKVILWRQLWLWLAESQQKLGLKITDEQLEEMRHNLEQVDFEQAAEEEARRRHDVMAHVYVFAKACPRASPIIHLGATSCYVADNADLIILRHAFTLLATRVARCIARFADQARRYRDVACLGRTHLQPAQPTTIGRRICMWMQDLLLDMENIERARDHLIRFRGTKGASGTQASFLDLFEGDDSKVVQLDELVAKRAGFSRLWSVTGQTYPRKLDVDLVSILSSLGATVHKICTDIRLLASFKEIEEPFESNQIGSSAMPYKRNPIRCERACALARLLMSHSTAALGTAGVQWLERSLDDSALRRVLLPEACLAADACLLILQNVLEGLVVYPKVVERNLMAELPFLATERILMWMVMHAGADRQECHERIRMHSQAAGDRVKLEGCSNDLVTRLSSDAYFAPIADHLNKLLEPRAFIGRAPSQVDHFLANEVAPVLERYSNELGGVSTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X625</accession>
    <name>A0A0R3X625_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain bifurcated histone lysine methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8928</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020628">
        <property type="protein sequence ID" value="VDM33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X625"/>
    <dbReference type="WBParaSite" id="TTAC_0000894301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000894301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000894301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6266852at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000894301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22313" checksum="F6C48880B21397FD" modified="2016-01-20" version="1">METGGVQILQTASPSEPVSDSDKGSPNVQQSVPTLGQHPGFILLSVKHEKIHNAQPAARAIPGGQKATTLPQRKVSRKRLRKLTPGSRNPDNLRAVDFDLLSTDCVPNLGASVKEGSSARSRFRVTRIADSSSWWIPENPKMYICVHDLRTSSLPDFVKIQYQKVLSSLSVGAINYSECGKDFWNCLEPNYLQNVNKGTGASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X697</accession>
    <name>A0A0R3X697_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9006</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020652">
        <property type="protein sequence ID" value="VDM33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X697"/>
    <dbReference type="STRING" id="6205.A0A0R3X697"/>
    <dbReference type="WBParaSite" id="TTAC_0000902101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6238451at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60204" checksum="6E72E1FA0F500C3C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6K4</accession>
    <name>A0A0R3X6K4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9126</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020687">
        <property type="protein sequence ID" value="VDM33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6K4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6K4"/>
    <dbReference type="WBParaSite" id="TTAC_0000914101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000914101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000914101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000914101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64890" checksum="CC26B9D112A32B18" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6K5</accession>
    <name>A0A0R3X6K5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9127</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020687">
        <property type="protein sequence ID" value="VDM33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6K5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6K5"/>
    <dbReference type="WBParaSite" id="TTAC_0000914201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000914201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000914201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000914201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36424" checksum="BDFA2A9FF4C9A81C" modified="2016-01-20" version="1">LAAFTRSYRTPINTGILFVPERQAWIIERLGKFHSVLSPGLNFCIPFVDRIAYVQSLKEIAIDIPDQAAITSDNVVLQLNGVLFLKVMDPYKASYGVEDAEFAITQLAQTTMRSEIGKIPLDNVFKEREALNYSIVRAICKASEPWGIVCLRYEIRDIQLPAKIKDAMQMQVEADRRKRAAILESEGQRDAEINRAEGIKQRQILSSEGQRVETVNKAAGEAEAIMRLAQSRADAVRVIASAIAGEKGVDAVQMAIAERYIDAFSKLAKTNNTMLLPTETGDVSTMVAKALAIFKSINPEKGVDETSSVSKPILPSRVYPAKHGDVKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7C9</accession>
    <name>A0A0R3X7C9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS9435</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020817">
        <property type="protein sequence ID" value="VDM34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7C9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7C9"/>
    <dbReference type="WBParaSite" id="TTAC_0000945401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000945401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000945401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000945401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="700" mass="80413" checksum="9566606D18885501" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7P4</accession>
    <name>A0A0R3X7P4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9554</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020887">
        <property type="protein sequence ID" value="VDM34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7P4"/>
    <dbReference type="STRING" id="6205.A0A0R3X7P4"/>
    <dbReference type="WBParaSite" id="TTAC_0000956901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000956901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000956901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="429"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000956901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="671" mass="73702" checksum="5026B4859FDD52DF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8I8</accession>
    <name>A0A0R3X8I8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Agrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS9848</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021107">
        <property type="protein sequence ID" value="VDM34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8I8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8I8"/>
    <dbReference type="WBParaSite" id="TTAC_0000986301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000040">
        <property type="entry name" value="Agrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
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        <property type="entry name" value="Transmembrane agrin"/>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="Fol_N"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
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        <property type="entry name" value="Kazal_dom"/>
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        <property type="entry name" value="LE_dom"/>
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        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
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        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FOLN"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_LAM_1"/>
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    </dbReference>
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        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
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    <keyword evidence="9 11" id="KW-0424">Laminin EGF-like domain</keyword>
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        <location>
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            <begin position="206"/>
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            <begin position="283"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="507"/>
            <end position="554"/>
        </location>
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        <location>
            <begin position="581"/>
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    </feature>
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        <location>
            <begin position="629"/>
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        </location>
    </feature>
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            <begin position="922"/>
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            <begin position="581"/>
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        </location>
    </feature>
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        <location>
            <begin position="601"/>
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        </location>
    </feature>
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        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
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        <location>
            <begin position="932"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1110" mass="121091" checksum="793F069B79C5EEF7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA58</accession>
    <name>A0A0R3XA58_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">TFG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="TTAC_0001043501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001043501"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001043501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18049" checksum="0AA4B4539D73CF7B" modified="2016-01-20" version="1">ESAIGEKSKSKQKSNRVVNGVAHHLESAHTQPTPLQDVIDAELAQQQTVKSNAGGVKSWADCVRGTQGPPMSESVKLSTPQQSQQPSIGQNGIRDHQPLRGKPAHLREPRDHRPARQSXXXXGGGGGGGRGRGNGSTPFRGGRGRGARGSFYPRGGFDAQSRRQASVEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA86</accession>
    <name>A0A0R3XA86_HYDTA</name>
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        <submittedName>
            <fullName evidence="12">Metallophos domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10446</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
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        <property type="protein sequence ID" value="VDM35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0001046301"/>
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    <dbReference type="OrthoDB" id="348678at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASM_C"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042283">
        <property type="entry name" value="GpdQ_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="9">
        <location>
            <begin position="315"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001046301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71317" checksum="13D73B368D377E7A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAA7</accession>
    <name>A0A0R3XAA7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10467</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021733">
        <property type="protein sequence ID" value="VDM35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAA7"/>
    <dbReference type="STRING" id="6205.A0A0R3XAA7"/>
    <dbReference type="WBParaSite" id="TTAC_0001048401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001048401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001048401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001048401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11687" checksum="2A4DD9DB740E4E49" modified="2016-01-20" version="1">MSVEVVVKKVDGDALEAAIKEDKLLVCDFFATWCGPCKALAPKLDAMAKENENVVFVKVDVDECQDVAEKYRVTAMPTLVVFKNGNEIGRVVGANEASIRELIQANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAH7</accession>
    <name>A0A0R3XAH7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10537</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021821">
        <property type="protein sequence ID" value="VDM35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAH7"/>
    <dbReference type="STRING" id="6205.A0A0R3XAH7"/>
    <dbReference type="WBParaSite" id="TTAC_0001055401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001055401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001055401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001055401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="22469" checksum="62F32E4AD5B37DC5" modified="2016-01-20" version="1">MHSQVCQPQSYSPRGPTAQFWRAIDSVNGSSGVSNRRVTLMAAATSTVAGDTTTMSSPGPTPSTPVSHRHSPVARSAPVSPAPPPPPLPPPPTFPSVRQQPHQTQSIIHFPHQPGSVALNVTHSLTPDFQSCSSPKTFHQDPLSGMGPRQGSLPRSDRSSSSPADEFAPPSLPPRSVSSLTSPSSGESVQQCNFRFKKPLILLKQFGLATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB34</accession>
    <name>A0A0R3XB34_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10744</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022173">
        <property type="protein sequence ID" value="VDM35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB34"/>
    <dbReference type="STRING" id="6205.A0A0R3XB34"/>
    <dbReference type="WBParaSite" id="TTAC_0001076101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001076101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001076101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001076101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43956" checksum="F5A4808530350E9C" modified="2016-01-20" version="1">MQQERFYRDTYAVLSNVDFILLRVEFLLLYKKLIPNLLLLLTGFDMTSEVGIALQRREIFSVEELSFHAAKGFRIFLKVINLFAPYREQRPLLVRILSREIYIIACILTQLSGLLLIWIGLIAKEHNLTYFVVNVFLIVPGLMHHRIFSRTWSVLKPYVDQIEAEFDRGQIESVAEREAGERELWEPLATSSFFHQPERRYEGSPGRFDTFDVDVDDYDASESQFIQSFIPHRLKLSKEKNKVALDAMTREIMETCRNQEEIDEWFSEVTQDPKHPEKRTRSASMTENRTGGTGHSSPNATSGAAGDHTFNSELDSAAWEEFSVSYLRHCFNLCSSAFFNDSVPQVNGAMVILDDLINMQIGDATVSTPKRQVIHIQVFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB35</accession>
    <name>A0A0R3XB35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS10745</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022178">
        <property type="protein sequence ID" value="VDM35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB35"/>
    <dbReference type="STRING" id="6205.A0A0R3XB35"/>
    <dbReference type="WBParaSite" id="TTAC_0001076201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001076201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001076201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001076201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17285" checksum="A69C97FEB504DDD2" modified="2016-01-20" version="1">MPILRRYCNCPLDRNRMSSNYQTQKKGALIVSDLRVDDFGYLCIHLTPITASNAYSLPHHFQLVTSEKRIIFLPFSAMLIYRVFHKCPKLPLKAVHGVLMILGLLFSVVGLKAAFDSHNLRGIPDMYSIHSWIGLVTVILFAVQVRYEALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBQ8</accession>
    <name>A0A0R3XBQ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10968</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01022622">
        <property type="protein sequence ID" value="VDM35948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBQ8"/>
    <dbReference type="STRING" id="6205.A0A0R3XBQ8"/>
    <dbReference type="WBParaSite" id="TTAC_0001098501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001098501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001098501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001098501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11056" checksum="1FB47F87F189CEDA" modified="2016-01-20" version="1">MQLSADISGVCRYNETGSIRPGVIGGSKPKVATPQVVEAIHRYKSETPTMFAWEIRDRLEKDGICTQETLPSVSSINRIVRNKALPYWQLHKNSQRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC40</accession>
    <name>A0A0R3XC40_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022961">
        <property type="protein sequence ID" value="VDM36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC40"/>
    <dbReference type="WBParaSite" id="TTAC_0001111701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001111701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001111701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001111701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24874" checksum="EEFE54532E50581C" modified="2016-01-20" version="1">MSSMQVEGKLTMISNYGGDVFLDIEVGLRWVWHRVIVYDADNVLLLNGRVGEEVRREDQSAYKSEYVAEDNENAHNDDVSLEPQQGDGVAAFHLPHQAKTIADFVFFGCVDFVLHPTFIPLRWMNTLWITKQDGGLLGEDGGMRDMRFLVSRHPSTRPSALGDAACLKVGASQTLLPLLPTTNFPPSFMRPLNRFNANYSPQHCHQMIGLTKHSNCGKKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC79</accession>
    <name>A0A0R3XC79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11138</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023040">
        <property type="protein sequence ID" value="VDM36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC79"/>
    <dbReference type="STRING" id="6205.A0A0R3XC79"/>
    <dbReference type="WBParaSite" id="TTAC_0001115601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001115601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001115601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001115601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="59" mass="6683" checksum="829B6DC8F20184DF" modified="2016-01-20" version="1">MSISTFPFGKGFAITILALIFVVDCGDYDRIYEVRDAIHRILRSVELRGARVLILANKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC88</accession>
    <name>A0A0R3XC88_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11149</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023062">
        <property type="protein sequence ID" value="VDM36129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC88"/>
    <dbReference type="WBParaSite" id="TTAC_0001116501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001116501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001116501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001116501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11835" checksum="5D00C85C12A6CE00" modified="2016-01-20" version="1">MTSKRVLVLKINHPTNLNERPVTVAKEPFPPASVNIAQHIDNQKPRLREGPRTIRLNSLIHADIQHSAMPDEAVAQEWRLHTAVVLQLQENVPQHHLDIHSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCK0</accession>
    <name>A0A0R3XCK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023403">
        <property type="protein sequence ID" value="VDM36240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCK0"/>
    <dbReference type="WBParaSite" id="TTAC_0001127701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001127701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001127701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001127701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="8854" checksum="9DC2C694FB1EBA7C" modified="2016-01-20" version="1">MNGCMLAGKDRNCIEVDVYGAYSSGPPLGVDETASGPDACSSSLQCPSPLGKGGSAEAINASTLTYAPKKWLLANEPEASALSIYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCU3</accession>
    <name>A0A0R3XCU3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KIF-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11353</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023757">
        <property type="protein sequence ID" value="VDM36333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XCU3"/>
    <dbReference type="WBParaSite" id="TTAC_0001137001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001137001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001137001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUP160 middle TPR" evidence="1">
        <location>
            <begin position="96"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="1">
        <location>
            <begin position="217"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001137001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47651" checksum="21B25B5D48F7BBB2" modified="2016-01-20" version="1">MPVLEQLDKSAHVIRLCEYALGIIQNASSDACAKGLLDCAANPRLASSVCGNASMSFDLDEWTTKVKTNYTGFFPPSAVCTDDAQFLSLAHDLFELEAVLRTRIFRHELAIGNIARAHALVISNPDKARQRDCLHLLITTLCDRGQTTELVNFEYGSLENELVSILKSRARAADVLPRSVARRQTLKGAVEQENVFYAVLYAYYVRRXXXXGAVEQENVFYAVLYAYYVRRSKFHSAVEVCYDQAIRLAEESALLPLALFRRAKSDGPLGAGSWVLAVLQKQALCLATCINTLELLPPQDQWIVRRESKVAFFNDVEPCAYTSDVSWAFDTEEEGDVSENHFDEGENGEKLAIEDILNSSNAIHRQARSRILQRTDLEHQYLVVRARLRLAQVSWEQGMLRARSTTLHDLYIALLDTAIYECAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCZ1</accession>
    <name>A0A0R3XCZ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023989">
        <property type="protein sequence ID" value="VDM36381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCZ1"/>
    <dbReference type="STRING" id="6205.A0A0R3XCZ1"/>
    <dbReference type="WBParaSite" id="TTAC_0001141801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001141801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001141801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001141801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24347" checksum="337B88271A437FC5" modified="2016-01-20" version="1">MWKNCLNSVHAHRTLRTYSYTPIPETGYSICVVTATDRDFDVQFLSQKEHLFAAADTVLVDGEDVSSLLLPVNVVLSPILANCRKPSFSRILASPTTTTTTETTPKVTTAEVTSVVPADATTLPSLNDSFDLRVTEMSIETMVATENETTDAEFEEKPWFRRKRNWLTDFFADDPKGVEQIMMILRFIQEYDFGNKYISRRISFYCICNALVAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDK9</accession>
    <name>A0A0R3XDK9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 184C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11619</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01025816">
        <property type="protein sequence ID" value="VDM37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDK9"/>
    <dbReference type="STRING" id="6205.A0A0R3XDK9"/>
    <dbReference type="WBParaSite" id="TTAC_0001163601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001163601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001163601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001163601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21602" checksum="1AC4CCA9299C407F" modified="2016-01-20" version="1">MVWRKWIKPVFIAFYTIALCIGLPFCIIALKHESASSMTFARFIGGVFVLGAIPISIWTILEHLISYTKPYLQLHIIRILWMVPIYAVNAWFALRFPKYAIYFDTLRECYEAYAIYNFLAFLLNYLRRKDANLNNHLATVTQVKHIIPFCCLKPWQMGRPFIEHCRHGVLQYTIIRPITTIIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE02</accession>
    <name>A0A158RE02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6387</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE02"/>
    <dbReference type="STRING" id="6205.A0A158RE02"/>
    <dbReference type="WBParaSite" id="TTAC_0000640201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000640201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000640201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9938362at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006019">
        <property type="entry name" value="PID_Shc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF11">
        <property type="entry name" value="DSHC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00629">
        <property type="entry name" value="SHCPIDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="309"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000640201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44694" checksum="D06F99FEA3CA00DB" modified="2016-06-08" version="1">MDVRLQVLNSKSVFGMNDSSILATYLIQYIGCIPITISIKSLNFQERTQITRECIIRVCEDVGLRVPPPKPPSVDGISKFIGKGTDLTWTRQSVRLSISVEGVTVQDFHSDQVLFHHRLGAISFASSGEADMMDFVSYVAKVEDATEGGKEGVANGEMTGGGGIRRCYVFYCSGGCSRDFISSIGEAFKLGYKGFKRSQRSQDPHPLPPRPVIDDLDPPLPEAPAPPAPSDPWFAPQGTAGTLGGQAFEDQFDDSAWLLQEHQAPAASGAQDQWVAFAPTQEESPQSVQESTKVGDGQWSSLEPVGEPWYVGRVTRQKAESLLQYDGDFLVRASTQQPNQFVLSGMQNGKKRHLLLVNPDGQVRTKDRIFSSIQELIDFHLRSTTPIRSADSELKLVFPVSPNCLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE13</accession>
    <name>A0A158RE13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat flightless-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6442</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE13"/>
    <dbReference type="STRING" id="6205.A0A158RE13"/>
    <dbReference type="WBParaSite" id="TTAC_0000645701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000645701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000645701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028421at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF0">
        <property type="entry name" value="LD07988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000645701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48626" checksum="6CB32CDFF760AB0C" modified="2016-06-08" version="1">MSSRMHNTRTGISDMVRTAQEGEIKRAATLKMSAEARLLRHQELERIRKQEEEEYTDDSNHARTSSSRYSSRHSSIEPTYTSGTYGNDPRELKRLLLQLDEKYKDVLVINAQLDCEKQFLTYSVDLLKDKLEDATESNQYNQKCAADRKKELAYQRMQLAELNHQLEIARQQIAIRDELITERGLVLVNVDGSESSAGIANGDTGQSLLNGATGCESSHSSATLQPSSHALPSSNAAPLAASSSSSSSSSYTILSKSNAEALKSICGSDIDSKIATLLEERAKDKERIETLKLHLAEERERIELVQKLDTRAKGGDPENLRQAVQAARSQAQEYKFRLEQANQKITGLEGDIIRLEGQVKRFKTIAENAEMQEDQLKQERRKIHRELREALSTIDDLKSENSTLQRKIDKLSRGPPGVPSGSSLRYYRGSSQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REK4</accession>
    <name>A0A158REK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7458</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020374">
        <property type="protein sequence ID" value="VDM31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REK4"/>
    <dbReference type="STRING" id="6205.A0A158REK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000747301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000747301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000747301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000747301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="289" mass="30832" checksum="5A19662B9D022AB9" modified="2016-06-08" version="1">MPSNLRNPDCRDSSPSLIVTTPPLQASPSPSPLNINLSVPPPALPVTMTTVSGLRRSQAILKRPTSGSGGGSNAADLSCAHIDPCVDLVLSRFLRSLRSSEAQVAANQAELQRSKFTEDSQNGKRMMSRLRVLEKENAELARQKESGRPAKIANLISLRRRFIEQIRMESARTEKLIDEAESEVEVFTSTLLMLQQQLSIAHATIEVLAVGLAAAPGSASPSASTPAKRCIALLQAAQWPLPSVLESGDVTNTNPIELSTIASPPPSHSDSLSLTTTTVDASPVTKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REW3</accession>
    <name>A0A158REW3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8187</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020460">
        <property type="protein sequence ID" value="VDM32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REW3"/>
    <dbReference type="STRING" id="6205.A0A158REW3"/>
    <dbReference type="WBParaSite" id="TTAC_0000820201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000820201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000820201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32698.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000820201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="886" mass="99674" checksum="479A89100F82BA06" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF07</accession>
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        <submittedName>
            <fullName evidence="8">Neurexin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8492</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="gene ID" value="TTAC_0000850701"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="Laminin_G"/>
    </dbReference>
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        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
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        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
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    </dbReference>
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        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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            <end position="791"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000850701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112309" checksum="8C50623297CA67AB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="8">Vigilin</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">TTAC_LOCUS8953</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
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            <taxon>Eucestoda</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020634">
        <property type="protein sequence ID" value="VDM33646.1"/>
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    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RF60"/>
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        <property type="protein sequence ID" value="TTAC_0000896801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
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        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="11"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
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            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
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            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
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            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
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            <end position="789"/>
        </location>
    </feature>
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        <location>
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            <end position="1075"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM33646.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896801-mRNA-1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EB55</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS2372</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001011">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
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        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="107"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="504" mass="57688" checksum="EE97FABC0CFCB6FF" modified="2019-02-13" version="1">MARSANVNDSSSYCLSSQPLTSTSFSKWSPTNSTGYLTPTLRAAWVTGTFLQNVSQQLVKTVGRAINFRSEPPSRPPLSEAEFRCYMDGLGRIVHPLDFYQNVYLRGIEVSLRKVAWRILLKIYPAEFSGNERRAFLLKKIEKYELSKRTWKQAYREGRLTKTQVNAITLACVDVVRTDRNHPFYHGGNNQRVSQLFSILATYAIYNPGIGYHQGMSNLASLLLYVQDGEGAAYACLCALMRRLAPKFAPRQDQITMITQMQHLHDLLVYTDYNMAQFLRMHNLGNMFFTERWLLLELIREFPFEEALHISEVQWAAIALVASNWPDVGSDALYSQLSSEQSFITFEAEDMHYTQCDTNLINSLIGDEFKYIHPCTNGTENVVVPPSIHSPSHKSQATKSIHEGDPVHMKDWIVELPSPDALGGGSNPFLLFICVSMILEYKGEILEKVHEVCDLFHLFQTYNKRHKLESILDRARDLFDAYLKDQEMKRRSILDCSNWNIHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EWU4</accession>
    <name>A0A3P7EWU4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WAPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005565">
        <property type="protein sequence ID" value="VDM25803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EWU4"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM25803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="115" mass="12981" checksum="5AEB16F2F09F99C9" modified="2019-02-13" version="1">MYTAGDKTKVSHESQERSSIQHALDDMNYLIDGLSDSNTTDTRCLSILSLANKCLTPATRDLVHAYGLLKQICANLHDAHTDYVSRLLTHFFKCLTYKKTFSLSFVPVSAYSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EYU9</accession>
    <name>A0A3P7EYU9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coatomer subunit gamma C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006712">
        <property type="protein sequence ID" value="VDM26543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EYU9"/>
    <dbReference type="OrthoDB" id="6372017at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="131" mass="14185" checksum="888A147C3D7C2059" modified="2019-02-13" version="1">MEELTLPVAVHMQRVIKANFAAAWEEYGEDGEAEETYFLTKFSTLDEMVRELVAHLGMQACERTDQVLSIDKVAHTLLLAGVFRGGVSVLARCKLAKSQPSAGQPAVGINLQITVRSAAPEINQAIADSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F0D0</accession>
    <name>A0A3P7F0D0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005502">
        <property type="protein sequence ID" value="VDM25776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F0D0"/>
    <dbReference type="OrthoDB" id="69989at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19062" checksum="2A39A51C483481FA" modified="2019-02-13" version="1">MPARAVTEKEACSVPSDCGRVAGAAGPMGVAGVGESAWAACLVPAPPDNATRLIRIVHNRARSPAVLFFGPVEELFSAVEISDYVPRWPQITPCRLPEIIATFCRYLFSLSGALVMFNVVPCYALDGQGIFKSLLDLALPSCVCSRQIRRLIFSTALWMGTGLVFLNIALALYCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F703</accession>
    <name>A0A3P7F703_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010291">
        <property type="protein sequence ID" value="VDM28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F703"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19272" checksum="2B91DB3AB243537D" modified="2019-02-13" version="1" fragment="single">MSSSYSAKSSSEVATRAGVNDESVKKENKEEDDEEEYAATTDPFYDKLPWFKSIGRCLVYLTNLYFDMSHEQELPLINRNGEHVGFIRVLVESRNDSSPPRSPALSPLFGPPSQGGQRKGHAKLHFDDLEYFTSEANGDSYCDNFAFGRFEPRLTPDPLATVRPIDPDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FHC8</accession>
    <name>A0A3P7FHC8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020545">
        <property type="protein sequence ID" value="VDM33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FHC8"/>
    <dbReference type="OrthoDB" id="6263093at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="340"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="531" mass="58946" checksum="9EC3DC8F05D1ED36" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQG2</accession>
    <name>A0A3P7FQG2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022425">
        <property type="protein sequence ID" value="VDM35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQG2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="197" mass="22024" checksum="C1426DA6C8C766DD" modified="2019-02-13" version="1">MVGRWRKITPFTGHGGWVCERGECMCLLVDRWKCASPKCIHFTSLPGCSSRRVANIPTVLDKLTLFQIVTPRLPHHSHPSVPHCGSLSLAPPLLPVLRFFLWTFSMPDSSDRNTEEEEEEEEDADVRTTAGEEGREQVAAFAWQCFNNPYKLQSSLDAKAGARLVGSHTTTHFTSGDIAAYVNGREVGAYKTWRCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FSI5</accession>
    <name>A0A3P7FSI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020392">
        <property type="protein sequence ID" value="VDM32084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FSI5"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="47" mass="5043" checksum="4954DA63EF2E86E3" modified="2019-02-13" version="1">MRTVAASLGLQVAARLPKRALQFGSRIAKTESLHKVIGADSNHQDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHM5</accession>
    <name>A0A0R3WHM5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS50</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000003">
        <property type="protein sequence ID" value="VDM15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHM5"/>
    <dbReference type="STRING" id="6205.A0A0R3WHM5"/>
    <dbReference type="WBParaSite" id="TTAC_0000004901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000004901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000004901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0041">Annexin</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000004901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32188" checksum="773CB6F52B36B60B" modified="2016-01-20" version="1">MPAKFDPDMDAQALEKAMKGLGTDENAIIEILANRTVNQRRKIATIYKACYGQDLLTRLKKELSGKFQKVVLGSFFDKPHLHAHALFEAMDGPGTKESVIIQVICTSNNDDIADLRDAYEDVLLEENENPLRRNIEKDIRSDLSGDFEKFIVALLQGVREQGVDRSAAEADVDALYAAGEKKLGTDEEVFTRIFSRRSYRTIRLLDELYCQKTGHGILKAIEKELSGDYKDAVATVVKTAFKKEECVADLIRDSMKGMGTRDDDLIRLILAYAEASLSMIPSRTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI23</accession>
    <name>A0A0R3WI23_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS222</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000014">
        <property type="protein sequence ID" value="VDM16094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI23"/>
    <dbReference type="STRING" id="6205.A0A0R3WI23"/>
    <dbReference type="WBParaSite" id="TTAC_0000022101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000022101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000022101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000022101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48254" checksum="447C589E3ECBBA0E" modified="2016-01-20" version="1">MTSLREVLEKAIVKHREVVASFRNQHGCKKVGEITVDMMYGGMRGVKGLVTETSVLDPEEGIRFRGYTISDCRELLPKAPEGKEPLPEGVLFLLLTGQIPSKEQVDSVSQDLVARASLPSYVLKIMKSFPATLHPMSQLVAVIASLNSESKFVAGYNKGISKNAYWEYTYEDSMDLIAKLPIVAATIYNNTFHGGKKVRNVDPNADWSKNFAYMMGFEDPLFIELLRLYLAIHCDHEGGNVSAHTCHLVGSALSDPYLSFAASMCGLAGPLHGLANQEVLAWIMDLVKSKGISPSDEQVLQFVKETLESGRVVPGFGHAVLRKTDPRYMCQRDFALSHMPDDPFIKIVSQCFKLIPPYLDSLGKVKNPWPNVDAHSGVLLQHFGMKEMNFYTVLFGVSRALGVCSSLVWDRALGLPIERPKSMSTDSLRTLFETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIN8</accession>
    <name>A0A0R3WIN8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS475</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000042">
        <property type="protein sequence ID" value="VDM16502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIN8"/>
    <dbReference type="STRING" id="6205.A0A0R3WIN8"/>
    <dbReference type="WBParaSite" id="TTAC_0000047401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000047401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000047401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM16502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000047401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="748" mass="83554" checksum="A439F6FB99DBA8FC" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIV3</accession>
    <name>A0A0R3WIV3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS558</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000055">
        <property type="protein sequence ID" value="VDM16644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WIV3"/>
    <dbReference type="WBParaSite" id="TTAC_0000055701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000055701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000055701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-kinase, catalytic, alpha"/>
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            <dbReference type="PROSITE" id="PS51545"/>
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    <sequence length="2469" mass="275492" checksum="C01D60BD7936CE22" modified="2016-06-08" version="2"> </sequence>
</entry>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000094101-mRNA-1"/>
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    <sequence length="354" mass="39346" checksum="3F516F321C7DECAE" modified="2016-01-20" version="1">MPSLRCYNKGCGKEFDPDDNGSDSCQYHPGEPIFHDAKKKWSCCNKYSTDFSEFLSMKGCTFGPHNPEKPAPVVVEKAAPQVNIAPPVQPVAKPIPKAPLPRPSSGSPLKVLAPVVSQSLKTALEALKLKDASGADITNDQGPKSCYNNGCKAVFSMDQKVIPRRVCITLVYRYFMKDVSIGAAVKERRLISKHSWLKKVVLPVDMRGQKRHVILPFIPITISKPDLMFFILERIEAITNGTFITPLTSQCRFDWFQMPDTVTLSVYAKNVLPESADVRCNSVFLTLSFLYDGGKSHFEKSFNLFGLIDPDTSRLNLMATKLEVVMRKAEACSWSALEVKASAPPEEEVRKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJY1</accession>
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        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">TTAC_LOCUS1005</name>
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    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GPCR-Ligand_Int"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        <location>
            <begin position="36"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17299.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="391" mass="44404" checksum="7F2893C982D70511" modified="2016-01-20" version="1">MSAHNNSTLNDQEINYAQWLIFGPLSCPVAILGFIGNYLTLQTLYQPQLSGINSSVFLKFLTTADAATIFFYFISFIIPVLASKGVVNWMDNSGYYHAIYPLALIAQTCAVYTVVLFSIVRYVSICHPFGLHAFRTRRVTRLMVSCIFAFAVICNLPRVFEHIPINLRVFNATCNCTEVRITRLGEQQLYISIYTSYGYTFGIFVIPVSIVAVLNARLGFLLHRVRREFAEKRDKIPQRIPMKGNLGGSNNPALESDIHTDQLEETHHFRSHIPGGIEASHNTQIIHARARVTGRLFCLVSVFIAFQSLPMVDNLMQAFMSDLVKAAFPNYSVFYAICQFSVMLNSSLNTVLYCFLGQRFRTTFLKMIYRWLDGFCAFFALLSCRTCPLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKC9</accession>
    <name>A0A0R3WKC9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1167</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000200">
        <property type="protein sequence ID" value="VDM17569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKC9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKC9"/>
    <dbReference type="WBParaSite" id="TTAC_0000116601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000116601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000116601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254538at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000116601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="522" mass="57898" checksum="3073EBCCEE41DC4B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKS1</accession>
    <name>A0A0R3WKS1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1322</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000261">
        <property type="protein sequence ID" value="VDM17808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKS1"/>
    <dbReference type="STRING" id="6205.A0A0R3WKS1"/>
    <dbReference type="WBParaSite" id="TTAC_0000133501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000133501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000133501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2151618at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000133501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9176" checksum="51D22003D4D2067D" modified="2016-01-20" version="1">MSEGVASVLAEVGDFQKDKLKHVDPAVKNVLPTADDVKNEKKESQLMHDIEQGTHLKKVKTVEKNPLPTKEDIEREKKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKS9</accession>
    <name>A0A0R3WKS9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000264">
        <property type="protein sequence ID" value="VDM17821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKS9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKS9"/>
    <dbReference type="WBParaSite" id="TTAC_0000134301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000134301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000134301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240089at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000134301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="617" mass="68843" checksum="FE4574AA2D77410C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL94</accession>
    <name>A0A0R3WL94_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS1519</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01000356">
        <property type="protein sequence ID" value="VDM18140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL94"/>
    <dbReference type="STRING" id="6205.A0A0R3WL94"/>
    <dbReference type="WBParaSite" id="TTAC_0000153201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000153201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000153201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="365"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM18140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000153201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45859" checksum="E7ACB15A163C9D3A" modified="2016-01-20" version="1">MQPFRDIVPVTQNGFPNVINPNTNSDSSLNPPIPKYNSFRGNMAITTDMYIGQHGRHNPATTQFGHTLQYHPNSIPQGLHNLPNSANCQISFNGFVSSSRVLDIWANNFHEGMRMVRRLAKGARYVAVDTEFPGVVAKVFGEYVNTFDQAYHNIKVNIDMLRPIQIGFSFFGERGQCVDSVATVQFNLKWNVDNETHAADSIQLLQDCGIDFYKLKRDGIEQQDFAEAFIGSGLALNDQITWIGFHSAYDFAYMMKICTDWLQMPEHVSQYQAMLHMFFPRIVDLKSVMAEHKFSKGGLQELADALHVQRVGFKHQAGSDSMLTGETFFRFLDEHSAGKLNPRFVNLVYGLNFCPNGSTNSILPMNGSPLESATHGGVYSPGASGSQHKETHSADHSGRNSPEGSLSGHKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM71</accession>
    <name>A0A0R3WM71_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="13">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS1846</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01000551">
        <property type="protein sequence ID" value="VDM18586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WM71"/>
    <dbReference type="STRING" id="6205.A0A0R3WM71"/>
    <dbReference type="WBParaSite" id="TTAC_0000185901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000185901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000185901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="16">
        <location>
            <begin position="371"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="16">
        <location>
            <begin position="471"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM18586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000185901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="606" mass="68943" checksum="BCE32EFE605DDB19" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMG7</accession>
    <name>A0A0R3WMG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1942</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000624">
        <property type="protein sequence ID" value="VDM18682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000195501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000195501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000195501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000195501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="22846" checksum="FBD4768F18CC0BE2" modified="2016-01-20" version="1">MGTNGTLNAYIQPAASSGSGVTMGACRDSSGSPSPTSWHLIAACPTTVVSSSANTAIRRPLLANNAVAALPDVQERKSFASKMSGVLFPQKSSKIRVKALFLNTAVQFVDQVHCENRQFSSPPSASMILLPPRATSPITTSKQKGFGDQNHQQQQLEPQPAYSDGSNTYYVINLDHRGTTTTPAAAAAALASKGGLLHPHPQQSCLTPLAPGPDSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMH1</accession>
    <name>A0A0R3WMH1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ETS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1946</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000626">
        <property type="protein sequence ID" value="VDM18686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMH1"/>
    <dbReference type="STRING" id="6205.A0A0R3WMH1"/>
    <dbReference type="WBParaSite" id="TTAC_0000195901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000195901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000195901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF184">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="363"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM18686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000195901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="479" mass="52648" checksum="40DE5E28868CB626" modified="2016-01-20" version="1">MSHLSDSPNSMAVDDPGVQLRSAGISITELVMMEIGFSLCGSGFAPGPMDSLMDSFWIDSSKILEPPLCELKPTSPGSTKSTSSLDSLLQGASNTASGSTPPLSPWPKDIEERLLPASPERKGSNFGDPVNSLWQSDVTCECHLSSSALPSPPTLPDQNQTKKTVLLGTDLLQGFDANEATSTSDGLEEQLASADNAWTAALELSGEAYMIIMATSRLVSHALQNDYSISDQTIKVNNCGINSDPESTETGSEGEDNLSKGASPQRNRSRVFIEGRIEVVEDLCSSDLDDSDEEDVGRSPTKKAALTSPLLSTSTQTLRHSQSSKIDYTEPWWPQRSSSVFQRLNAREFDVGGGGIGRSRRQLELWEFILRSLDARPANDTGSAFKWVNRSVGVFRVTDTQKAAKEWGLYRGNERMDYEKMARAMRDFAQVLDYVFCRFYYKECVLRKASKQLHFQFSMPFVSWSQRHNSCESFSTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMU2</accession>
    <name>A0A0R3WMU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aldo_ket_red domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2067</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000729">
        <property type="protein sequence ID" value="VDM18828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMU2"/>
    <dbReference type="STRING" id="6205.A0A0R3WMU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000208001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000208001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000208001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000208001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32403" checksum="87955E710B87B93F" modified="2016-01-20" version="1">APKELVTNAVEVALSVGYRHIDGARLYANEKEVGAAIAASMKKLNLKREDVFVTSKLWCDKHAPEDVRKACEVSISDLGVGYLDLYLIHRPESFKVKEGVAFNNADPSTVVFEYHKIEDTWRAMEELVSAGLVKSIGVSNFNKRQMERILASCTIVPAVNQVEVNVHWLNTELIEFCHSRNIVVEGYAPLGSTGFVKGQVKPVLEEESVVAIARKHNKTPAQVLLRHGLQRGIVVLVKSVTPERIKSNFDVFDFELTDGEMAKLNSIGVNKRVFRALALTKHPEYAFKDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNA3</accession>
    <name>A0A0R3WNA3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000866">
        <property type="protein sequence ID" value="VDM19301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNA3"/>
    <dbReference type="STRING" id="6205.A0A0R3WNA3"/>
    <dbReference type="WBParaSite" id="TTAC_0000224101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000224101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000224101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000224101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="76" mass="7895" checksum="ACBAE01000C9F9F4" modified="2016-01-20" version="1">MYVVVARFDGNIMVLPVGWTEAVEVWRGLEPTGYAAAVASSYASGGGTFYAPMNASADATASVQAPPPALMTREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNA8</accession>
    <name>A0A0R3WNA8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PGG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2233</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000875">
        <property type="protein sequence ID" value="VDM19317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNA8"/>
    <dbReference type="STRING" id="6205.A0A0R3WNA8"/>
    <dbReference type="WBParaSite" id="TTAC_0000224601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000224601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000224601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000224601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32290" checksum="95A51A0E94DFB18D" modified="2016-01-20" version="1">MDDPDFHQFVYIQPKPGIKFNVSRELPSLAAQACRNLQKVFSKRRGKALDNGDVIKLTCIALAIPILVDILCTLCTRKAKHYGISGSVFLPVNFALIHTIFVVLLLEFRTKAPGAPTIASFVGHRFGVVTHILTITISLITSLYILTVNITDGTMVLLAVTRDVSRTATVSIVFLLVGVMLVVARRRSHAFILYIITTIVLAICAFLVFIVLNVSAYAPLGTFPLWFNPFLSLKVKHFGYLGVLYRKLSSKEVETGETADGFAIISHRSCDHNRKNSSRSKAEKVEFHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNB2</accession>
    <name>A0A0R3WNB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAGUK p55 subfamily member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2237</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000879">
        <property type="protein sequence ID" value="VDM19334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNB2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000225001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000225001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000225001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="244"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="354"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM19334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000225001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="766" mass="84204" checksum="3787278004373279" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNJ5</accession>
    <name>A0A0R3WNJ5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2320</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000961">
        <property type="protein sequence ID" value="VDM19632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNJ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WNJ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000233301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000233301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000233301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM19632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000233301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13379" checksum="75A1412665B1A618" modified="2016-01-20" version="1">MGKRKKLFIAFDEEKRRDYLTGFRRRKQERRAKARLENENKLKEEIRNVKQVYHDEMKKKLESVTMPSFLADDLNVVSKRTITDTGEHTVSVEEINIAQSHYFMGENVRYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNM0</accession>
    <name>A0A0R3WNM0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS2345</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000984">
        <property type="protein sequence ID" value="VDM19735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNM0"/>
    <dbReference type="STRING" id="6205.A0A0R3WNM0"/>
    <dbReference type="WBParaSite" id="TTAC_0000235801-mRNA-1">
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    <sequence length="514" mass="56339" checksum="139CB0A4C1EBE8C2" modified="2016-01-20" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="VDM20037.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000244601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40993" checksum="584FF1FEC983623C" modified="2016-01-20" version="1">MHGIYKTSPLSTQRSLITEDELNELPTMAFEPSLVAPWTRCSSGYPIEIPVCLGATLLCLRDLHEAELKKGHSFIDDYSPSGNFNPPNLEEEAEDLANWLLDEVTTYAECRPNLLTKNARLLFESILLILERLKTPLYPLSEKTCNLLRKLSLLEPVHPYCMHIIQVLFEKAMAFCADTESKQQSGVINLDGYSTDITEFIQKTYSCNNISRHDRIRLTNLFNLHIFHDLYMVMENKTRNIIRVIIRNLIFIVQRYIITMCAELKAKRQETWLLNTINMRPHICEYAIVAIATRVGPRMFRFPRSICMQNELAVRAMINIFSANLDNMWLPGQKPSSIKVETGAAKCHSGCICHHDE</sequence>
</entry>
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        <name evidence="3" type="ORF">TTAC_LOCUS2441</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="VDM20056.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000245401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15134" checksum="4CE601A915E7637A" modified="2016-01-20" version="1">MVSATSHVTMCLTIIYGIIVIFACVVAVPLGEVDSNPEGPNQIVYFGAFKEGGTTGPSKLLWWVGERRFFEPSVSGFVTLEGTEAPKSSSVTTAVEGTENTSEVPKLHSSFGSDSTARMRSTFSPLQVHYDDYNYPSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP62</accession>
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <location evidence="1">Nucleus</location>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR16500:SF3">
        <property type="entry name" value="BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY"/>
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    </dbReference>
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        <property type="entry name" value="ENT"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51138"/>
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            <dbReference type="EMBL" id="VDM20382.1"/>
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    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000255001-mRNA-1"/>
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    </evidence>
    <sequence length="625" mass="66378" checksum="033DF01C199AAE78" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPG0</accession>
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        <submittedName>
            <fullName evidence="3">DUF1559 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TTAC_LOCUS2635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001308">
        <property type="protein sequence ID" value="VDM20733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000265001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000265001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000265001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000265001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11020" checksum="7E71CA66418EED34" modified="2016-01-20" version="1">MVSTVATTIGPWGDKRHYFTCKSTSQLHGEEGSQYIATDFALAQSLPMPRQVNPQLGDSPPLCGGHRNFTIVATSNAVFALQHCGRANGMRTLLAIDPDPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPH2</accession>
    <name>A0A0R3WPH2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 299</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2647</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001327">
        <property type="protein sequence ID" value="VDM20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPH2"/>
    <dbReference type="STRING" id="6205.A0A0R3WPH2"/>
    <dbReference type="WBParaSite" id="TTAC_0000266201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000266201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000266201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2136125at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027887">
        <property type="entry name" value="DUF4464"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14713">
        <property type="entry name" value="DUF4464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000266201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28322" checksum="988AD73C718A44CD" modified="2016-01-20" version="1">MNKCRVDGLDRIADGYENYEDFLDSQITETDLFYLEDEELARELVELGYRGTSEIIKREQFIKRKDELAALAEKRKVAKKALDHEGIIITEPGLLALAAREESNRRGNLSVCELFIYVLHKTIIFIRHTNTKGQEISGYVDYAHRLKNEDFVPYFSGKKKLLPRVGDLSFYNWESQHVSSTSTPNYIVIADNPSGLLFKNKRDRKLIIIDPWSQTAGDNTTRTAVYTTEYKQFILYDHITRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPL1</accession>
    <name>A0A0R3WPL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CABIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001378">
        <property type="protein sequence ID" value="VDM20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000270101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000270101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000270101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10513112at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000270101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40358" checksum="90F1B7FBE86E7FA5" modified="2016-01-20" version="1">MVESNLVFFFQEGLFYQVRVIELRHNRHPHHVLYKDQLGSLLAVPEIPDIGHFPLPRRGMVMVSAEPTTGCSVEYPSIGVCWSFCISHLTWLAPNTGGACLQHNSTVGIHAGNVLQYARVLESTLSCDLLTHTIGGLGVNSDSVLLRLDSSHKVVVTFIRQPEFLELGRQVVISVNNVARAVGTVTAFEHLTTAFSNPPLAVPDSIFSITSATAASSSPWHTVLNSPSDSSFESLLSQVGIDPQGSHTNFVSEAPIPPELEASENLSSIIQHNRRRQRNAKRRRKAAARLALMAAPISEVASSTSTWNSNSNGSMPLMMGCGEREMKCEDVNVENSQSLMHSATITNAPTYSLTSQRRRKRKRRHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPP1</accession>
    <name>A0A0R3WPP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WWE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001425">
        <property type="protein sequence ID" value="VDM20972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000273101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000273101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000273101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000273101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17900" checksum="A233D25E473D591B" modified="2016-01-20" version="1">MLKLSCNGFFLSDLRLKIQRDINADGRIHCFGIPASQATSMDNDGGDDDDDDDVSAMVALVKHQQQQQQCPLTGSKHASTNTTSGSSSNPYGNVADASTQLTTASAPALNVSEIAPKVVQRAQGAQHAASPQIPPPPPPSPPTISESVRHEVKKPSKWRWETKMRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQC9</accession>
    <name>A0A0R3WQC9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2954</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001729">
        <property type="protein sequence ID" value="VDM21597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQC9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQC9"/>
    <dbReference type="WBParaSite" id="TTAC_0000296901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000296901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000296901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="2">
        <location>
            <begin position="408"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000296901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="638" mass="70436" checksum="AC8AB04348258F0B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQI2</accession>
    <name>A0A0R3WQI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3007</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001797">
        <property type="protein sequence ID" value="VDM21734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQI2"/>
    <dbReference type="STRING" id="6205.A0A0R3WQI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000302201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000302201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000302201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287768at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132944" evidence="7">
        <location>
            <begin position="24"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="310"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM21734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000302201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="715" mass="78954" checksum="D9AE9ECA56FCC482" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQQ1</accession>
    <name>A0A0R3WQQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ING domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3076</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001888">
        <property type="protein sequence ID" value="VDM21904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000309101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000309101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000309101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6257300at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000309101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7817" checksum="722ECEBACD86ECAD" modified="2016-01-20" version="1">MDDLLSYELPDASIYDSLKSSLRKVHDKMDVHRSLLDRYSAIDMKDGPSSVEERVASKCRELGERMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU6</accession>
    <name>A0A0R3WQU6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001955">
        <property type="protein sequence ID" value="VDM21998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU6"/>
    <dbReference type="WBParaSite" id="TTAC_0000313601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10525960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18026" checksum="DEF2B17A92EDDAFF" modified="2016-01-20" version="1">MFNLISDFRSSIGVLHGKIIKSSIVYYYLSIILWTMLLFISWRRFPHCYSPWLSVVWLIGNVFVSSSRLWLNRLLDDMCIAESISYVIRPLVLILWPFIHISLGCFGAAFVGGGNYVGCLLYHHFFIIKRLFDVNSKVSIGNMFDVIFHRLQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRJ5</accession>
    <name>A0A0R3WRJ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3370</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002325">
        <property type="protein sequence ID" value="VDM22487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRJ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRJ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000338501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000338501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000338501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994106at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133064" evidence="6">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM22487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000338501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12402" checksum="DCAE89E5C99B994A" modified="2016-01-20" version="1">MIILTVIMVGYAVAAQSIAYPNGFYTSEQLSLNGTVQGMKFIDTIFSMYTTAYFQMFGDFSLDTLQGEDRNCQNGMCPTKTSRWLVPIMLGFYVLLTNILMFNLLIAMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS00</accession>
    <name>A0A0R3WS00_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3525</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002581">
        <property type="protein sequence ID" value="VDM22807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS00"/>
    <dbReference type="WBParaSite" id="TTAC_0000354001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000354001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000354001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277404at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000354001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20956" checksum="55FCC87033AC1E4B" modified="2016-01-20" version="1">MQYKGMGLVDSASHYIPQIESGNAKIVEVKDACVGADSKPEADDLKRTILFDHWRRRLRARDFVDRLLEKEAKEAKTRRRRCRVNPSHSAPHPPLPPPPPLPPPAPLRMHFGTKIENGLMTEDRFCCGRQKDGLIDFSSSVGASASSTSTPTLSLPLTSLSSFNTLPAWNWPSLNGSTKNLCSYYHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS56</accession>
    <name>A0A0R3WS56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3581</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002671">
        <property type="protein sequence ID" value="VDM22914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS56"/>
    <dbReference type="STRING" id="6205.A0A0R3WS56"/>
    <dbReference type="WBParaSite" id="TTAC_0000359601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000359601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000359601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000359601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18693" checksum="358890A0E28F5893" modified="2016-01-20" version="1">MFSSDAYLSKKKDHDDHDERLAEYRESFDLFDKDKNGRISTKELKAVMSSLGQNVTDAEVQQMIRQVDLNHDGEIDFGEFVKMMNTCKPTSDLERLQDAFRVFDKDGNGYITVDEMRQVMFNLGEKLTDEEVKDMIKSADIDGDGQVNFEGTSKIIRFSIINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS81</accession>
    <name>A0A0R3WS81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neur_chan_memb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3606</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002718">
        <property type="protein sequence ID" value="VDM22962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS81"/>
    <dbReference type="WBParaSite" id="TTAC_0000362101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000362101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000362101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261841at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM22962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000362101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22399" checksum="6D853C37AC42D43F" modified="2016-01-20" version="1">MVAGLGRGKDASIGKDESEVGHEVSVRGSPSPLYRRFLANLRRLRGVPCGRQYTRVSIGCILPPGGETHIHPTEWNERWVEDKVNAAEEDEISNCLCLMREMKRGYSVSLLWFKRNVIVVRIFIILGDVLTFGIFLWVLVFATYLLTDPAIEKQHIIGIINNDTMPYPPQPDFDIQEHISTIVAYHLGVDVAVVWLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSS5</accession>
    <name>A0A0R3WSS5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS3799</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003078">
        <property type="protein sequence ID" value="VDM23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSS5"/>
    <dbReference type="STRING" id="6205.A0A0R3WSS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000381501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000381501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000381501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132978" evidence="14">
        <location>
            <begin position="23"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="68"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000381501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61340" checksum="D734797D78BC6DF7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU63</accession>
    <name>A0A0R3WU63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4289</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004081">
        <property type="protein sequence ID" value="VDM24613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU63"/>
    <dbReference type="STRING" id="6205.A0A0R3WU63"/>
    <dbReference type="WBParaSite" id="TTAC_0000430301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000430301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000430301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000430301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24350" checksum="37A28C9BCC94C37A" modified="2016-01-20" version="1">MLNADTTKSEDTLSTEMECLGDKVVKASHLLEVQSEGHRSTIETREDQLQVESQPLAIASPGVTTASTPKRHHPASPVINYATDETSVGNAAQSKSEDSASSTTSLSANSAASPPLEDLEQEKHVEDCDMTRATPLLNENSLVNVKTSASSIRQSAAKRQHLAQMGTIETGLFFPGLMHRDRTSQILLEPKLLPGLRGYRTAFLFHKICFIFNFGIQIWLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUK6</accession>
    <name>A0A0R3WUK6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Girdin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004402">
        <property type="protein sequence ID" value="VDM24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUK6"/>
    <dbReference type="STRING" id="6205.A0A0R3WUK6"/>
    <dbReference type="WBParaSite" id="TTAC_0000444601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000444601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000444601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064612at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008827">
        <property type="entry name" value="SYCP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05483">
        <property type="entry name" value="SCP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000444601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37121" checksum="6B5598376F8B9CD4" modified="2016-01-20" version="1">MAKFFGVNLFKKSSGHSADTSLMKKDSGSSDVSESTKNITNASPVMWDAICDLNSSSDLDDTADFFYSRSGIFSSQCDKPSSPTQIALEKAQKSVTNSGTNKWKTNFLVPESSLRLPRVAEPIPISPSLSRFQSKSQASPSMGFLHSSKLCQSPAFKSNSNTLDLAIAERDTSSDRVNINSPKAIQVNADIEKRELSFAEPGTSLDLSTFDLDQTNDEEQQDANYQHHPKEDKANVQRSPAYEAEHYKEVEISNSSGCDKLAILHMKLKNEAIKLENWKNEMISKLNKNEEKLAEANTLVASLRKSNLELQMDRENASLKVKDEVEKREAVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVF3</accession>
    <name>A0A0R3WVF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4729</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005187">
        <property type="protein sequence ID" value="VDM25538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000474301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000474301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000474301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000474301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15558" checksum="67762B49135F5E14" modified="2016-01-20" version="1">MNDSDTTVTLVLFNSIPTLRLLRYLANMTTCEMVSGNAFTTATLTIDWLARATDTTDSTHSTTHSINCTHMLLQQHHQSSCLLIVSCISTSHCSEEERALTSTASTLAPSPSIQEATYASSTEAVFGGGFFAISSFRVGKGTESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW38</accession>
    <name>A0A0R3WW38_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAF-like, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4964</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005792">
        <property type="protein sequence ID" value="VDM25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW38"/>
    <dbReference type="STRING" id="6205.A0A0R3WW38"/>
    <dbReference type="WBParaSite" id="TTAC_0000497801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000497801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000497801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000497801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32284" checksum="89A30C21C1B20597" modified="2016-01-20" version="1">MDSPWDSTDEEEAKESLHPLVPQDGDRNSQNASSQSESSPWDSEVETNEVKELNEVSVSTLTQVSESSDKDISIMEEFSKVPIILNTDNSLAEAANRAAASITRVLLNEENGGRLNPTRDLWPIDEQSDEDFRLAAKKCPHSHQEEEEEEEEELPSANNLHQSVVKSPLSEPLCSSRSQSKKTDQDKSGGTTGESTPESNRTASIPILPSYYPTPSLNQTPSRSESTKHKTPLTSPVRGDFGTISPQPRRSRSQLRKETPLSQHMLSPPAPPAEAIECSVNRGKLILLVSKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW56</accession>
    <name>A0A0R3WW56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005844">
        <property type="protein sequence ID" value="VDM25985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW56"/>
    <dbReference type="STRING" id="6205.A0A0R3WW56"/>
    <dbReference type="WBParaSite" id="TTAC_0000499601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000499601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000499601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10436725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000499601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25214" checksum="FFED34A82F79181B" modified="2016-01-20" version="1">MYRYFYTNFQMLRILIPAPSEEPDYEKSFRLIILDAKNRLDIRVRRAVQPPAEMQQRRMYTVSSNSGLSSLAALVPSLAARQIREANIATPINRLVKRGIPTTSASTAMTYTVNRVLPIGPPAEVVYVLILFLLLLFVIHVLGHITQPDPSHYWIGCTPAQTSDPNATTSAAIFTFRPPDKVTPLTYWRRVFVLVIYLCLKSAYTFSVTLTALIIVTRYFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWA2</accession>
    <name>A0A0R3WWA2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS5026</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01005996">
        <property type="protein sequence ID" value="VDM26095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWA2"/>
    <dbReference type="STRING" id="6205.A0A0R3WWA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000504201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000504201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000504201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM26095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000504201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12539" checksum="1A3375260D11AA2E" modified="2016-01-20" version="1">AAIGSGDGTIDRKSYQLPPGAAGLAVRTAIRDASEGADIIMIKPGITYLDVIASVRRELPFHPIAVYHVSGEYAMLMAAANAGCVDLKSAALEIILSFRRAGMSGDLISLLRRVYFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWL4</accession>
    <name>A0A0R3WWL4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006367">
        <property type="protein sequence ID" value="VDM26341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWL4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000515401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000515401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000515401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000515401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18381" checksum="90C1158274A12DB5" modified="2016-01-20" version="1">MGIVLIRNEVESINDCRPVQIKLHLCQENSNTAFYDSPTYSPVVGEFAYSSEPMHTDVIDESALWKMVREQEAELRRAHYNLPRTDPPITTNKVDEEKTTEFETSAVLITPRLYELSTSSEEEDYEVKGPPNSKDPLEVGVTAAALKGLDDLLDPGHGRGTSIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWT2</accession>
    <name>A0A0R3WWT2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF5727 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5207</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006604">
        <property type="protein sequence ID" value="VDM26473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWT2"/>
    <dbReference type="WBParaSite" id="TTAC_0000522201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000522201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000522201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10292162at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043785">
        <property type="entry name" value="DUF5727"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18997">
        <property type="entry name" value="DUF5727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133065" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5727" evidence="2">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000522201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20007" checksum="2F7EB8523D6F2432" modified="2016-01-20" version="1">MLGGVVFLAVVAYCSGTDPVLWGSRIVATASGRSPTMHFRLPEQPVMMAFWKSGRISPITIVGGACYLDGSEEGRPCHISKESVNITIDDVLKFAYLHIRTATSLFSTAIFVPRCAFEEPEEDEVDLKASFPLSRFRKGHSHVELKFAVRGANGEYWVRVCAFVGALNRLFKCAYKTCSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX05</accession>
    <name>A0A0R3WX05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006849">
        <property type="protein sequence ID" value="VDM26608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX05"/>
    <dbReference type="WBParaSite" id="TTAC_0000529501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000529501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000529501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276075at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000529501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="26952" checksum="87CCD247E68025B4" modified="2016-01-20" version="1">MRANVGKEGTIEGGLSGSKRSIERGRARGTTLARTPLRIGVEKDGVGGGGDGGGGGGGGDGGGVGGEMGQKEARQCRGLNDGIRWMLESGRLSANSRAARLLHNHLAGKEQPPPPRKSIIRVKWGETVVCHMRVFGCAGAVAVVVLLTHSLPVIVVELCSPCTETSSVSDLEQHATGGSNTLGQCGAGKWDTGVAKRSPSSPVTRDKEQCSQGVWGWHSPSNSTTVGACCSLNRHMQPHQLASTRHSSCSDVSTTCGLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXN0</accession>
    <name>A0A0R3WXN0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5504</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007768">
        <property type="protein sequence ID" value="VDM27111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXN0"/>
    <dbReference type="WBParaSite" id="TTAC_0000552001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000552001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000552001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000552001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10018" checksum="8074DD65800B8E78" modified="2016-01-20" version="1">MAVWEVGYRIVSSNQSEPACGCGGFAGGGGEGSVIVIVVVVVVVVGGGGGGGGGGVGGAVTDGWMVWQTGRLGVVVKVVARFLPPVQCVTITVVVAMIVVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYS4</accession>
    <name>A0A0R3WYS4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small integral membrane protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5898</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009603">
        <property type="protein sequence ID" value="VDM27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYS4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYS4"/>
    <dbReference type="WBParaSite" id="TTAC_0000591401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000591401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000591401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000591401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10369" checksum="ABD50EC70854A950" modified="2016-01-20" version="1">MGCFIEGPSASTLLSLDLHLSFSFPETANFAWIAAVVIAIVFILIVIIVSVWLCTRNRGETYKLSKKEYKLGNDPLRELKEKETFQTYERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYX9</accession>
    <name>A0A0R3WYX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009923">
        <property type="protein sequence ID" value="VDM28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000596901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000596901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000596901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000596901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11383" checksum="50D02F2C2CB24504" modified="2016-01-20" version="1">MEEGVELLWMSCRQDHLVNGSTEWEALCRDVLIVSKLVCVYTLGWKRLLLRSTVVEACRVCVRFRDTLESMLRRWRTAYGFISGAMMEQMCTPYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ58</accession>
    <name>A0A0R3WZ58_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010319">
        <property type="protein sequence ID" value="VDM28255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ58"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ58"/>
    <dbReference type="WBParaSite" id="TTAC_0000604801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000604801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000604801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285083at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000604801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15245" checksum="1848E0FAD4E7DA22" modified="2016-01-20" version="1">MTRFLLALCGVAPNHKITSFEEAKAIDLINERMPPRHDLSSGSSTNSARTRTSSSCSCSHHPATAISTSGKQQNSSGNSNNNNGERSSSSSQYHHRHRKSSGNTPEKIGSSGVADHRHRPSGLSTNSSASSSPRTSNATATAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ87</accession>
    <name>A0A0R3WZ87_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YfhD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6074</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ87"/>
    <dbReference type="WBParaSite" id="TTAC_0000608901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000608901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000608901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274722at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000608901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="36" mass="4150" checksum="405472D93C4494B8" modified="2016-01-20" version="1">MSKTQGTQFIPIEQRPLKDFEVEDDEDKPPASKSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZI5</accession>
    <name>A0A0R3WZI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZI5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000620801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000620801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000620801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10035275at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000620801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45603" checksum="3C1BF3A7B1330FAD" modified="2016-01-20" version="1">MHIGAFLELLPTKSPTDFELRLDFAFIILNREHFSKNQHFSQRQVLFTRDGRKHGCKTLIELSYLCGDKFLSDDNTFLFEVDFSSPRVDLLVQLYSTEELIHFLCNNYVDRYNAEDAEHGPILFESGPFNASREPWHLGVAISHASIFGPDKEVKKVSLYIFRRRGRKSPSEVSGRHLSIIEFACEIESQTSGRRLQFLLDPDCGMSLMEELPQNEANAVSTLVREQIASHIAKKVSFKFFNPILHVKLKSVRLRHLTPRELVLLRPPSPLYCSTVPFDPVNTYWTAYAYPIGNELSLGLRVAVNKNKKLLANNCVDLLWWSAHADNGNVKKAKCLDENRKVALSVATRFHQLDSVEVSNLGVDGSVSDDGVPTEALSPSQCSIGLPQKEQNNFLVSNIAFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZJ6</accession>
    <name>A0A0R3WZJ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6206</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZJ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WZJ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000622101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000622101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000622101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133062" evidence="11">
        <location>
            <begin position="19"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="545"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="615"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000622101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="909" mass="101518" checksum="050A59292DED8057" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X033</accession>
    <name>A0A0R3X033_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6440</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020304">
        <property type="protein sequence ID" value="VDM30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X033"/>
    <dbReference type="STRING" id="6205.A0A0R3X033"/>
    <dbReference type="WBParaSite" id="TTAC_0000645501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000645501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000645501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="8">
        <location>
            <begin position="556"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="637"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM30653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000645501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="741" mass="82681" checksum="DD8F528C05D2A09C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0W2</accession>
    <name>A0A0R3X0W2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6784</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020322">
        <property type="protein sequence ID" value="VDM31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0W2"/>
    <dbReference type="STRING" id="6205.A0A0R3X0W2"/>
    <dbReference type="WBParaSite" id="TTAC_0000679901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000679901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000679901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF185">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000679901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="414" mass="48750" checksum="CD8520BC3EF1C12C" modified="2016-01-20" version="1">MRKKGVSVVRIVGLVLKLSLLALVVIDLGHLTYEYRLKAYVFTFLASKFTVPSVVGSPYVCENNSWWFTPNATGQEPWEHILKEEEEFPLAYTILAFERPDQVWRLLRSIYRPQNYYCIHFDKKSPELYKKWLRRKIATCIPPEVSQNVFFIPSISVYHSYMSVLEADLDCMRALWKLPGKHPESNAPPWKYLINLTGQEFPLKNNLELVRILSVLNNANLIQQEKFFYLRRAWRDPPHGLQLYKGAVHVVLTWDFVDFLFTDQWVKDLLDYLPEVGIPDEALFSTINHNAVLNAPGNFPKGDEVYRSGGYYVNRWKHFFPAECSGVWRHSVCIFDLYGMQPLFKPDSPYLFVNKFVMHINAPVLDVTEQWFYDRQEWYYHHADQNLTNLDFFRNLPQVRYQMLRGSQSIPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X167</accession>
    <name>A0A0R3X167_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS6905</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X167"/>
    <dbReference type="STRING" id="6205.A0A0R3X167"/>
    <dbReference type="WBParaSite" id="TTAC_0000692001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000692001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000692001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000692001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35743" checksum="F8557DAD9AC9FC24" modified="2016-01-20" version="1">MGSECLVLGLFGQIVIGPPGSGKSTYCAAMQEFLTELGKVVVVNLDPANEELPYSCEVDLRDLITLDDVMEALQLGPNGGLLYCMEYLYANRQWLADRLRLFRQQSAKTYLIFDCPGQVELYCNNTAFRKLITFLTYSSSASNGSPSEPAAGLGLRLAVVHLVDSHYCTDAGKFISVLLTSLVSMLQLSLPHVNVLSKIDLVELYGRLPFNLDFFAEVLNLSHLVEQLEDDLFFAKYKRMNQALADLVQDRSLITFQLLNVQDRALLQRVLQCSDKANGYVFGGEEQHSLQALLSCAAGIEFAGDLVCMAQERYTSRPLPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1D2</accession>
    <name>A0A0R3X1D2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1D2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1D2"/>
    <dbReference type="WBParaSite" id="TTAC_0000700501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000700501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000700501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000700501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36458" checksum="DE609177E1B88601" modified="2016-01-20" version="1">MNVFRNLLYSIQVCSNWLTAAFTVDRYLMICHPFIAKRWCTLRLSKFVIAAVWMTSFCYTLPRFYEYVYFTPLPHPMTRDSRLHLPNHWYQLSVLGDSKAFRFGYHLWAWCILVIGLPSLFIAVLNIFLVREINRSIKRMRCEQGIKTRRHETDVMLIGVIVIFFVCQIPSSVSHVMWGIRGYRQEESVPWLILNEVGNLFVILNASINIIPYYLFGKRFRTLFVVIYFGWMKRCTDVRQRVTPFNHLLQSAPNGRPRMPSASSPLSPPAIAGVSGQDQFPSLHCFQPGGEGTCLHVESQKPQQPNCCLFSGAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1E7</accession>
    <name>A0A0R3X1E7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial dicarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7007</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1E7"/>
    <dbReference type="STRING" id="6205.A0A0R3X1E7"/>
    <dbReference type="WBParaSite" id="TTAC_0000702201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000702201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000702201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="95"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="195"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000702201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31693" checksum="0E9F6D2195C6B4C7" modified="2016-01-20" version="1">MSNKPPAKAGYWYFGGLASAMAAAVTHPLDLLKVHLQTQQTKEFGMIRMGVRVFKSDGILGLYNGLSASLLRQLTYSMTRFGVYESYKNSVGRKMTFAESGGVAMFAGFVGGIVGNPGDMVNVRMQNDVKVPPAQRRNYKHAIDGLFRVAREEGIGALFNGVSMTATRATFMTFGQLAFYDTFKMMLLATGFFHDNPVTHFSASIGAAGVATCMTQPFDVMKTRLMNAPPGKYSGLAACGLDVLRTGPLGFFKGLVPAFIRLGPQTVLTFIFLEQLKANFGYIPTDIAKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X245</accession>
    <name>A0A0R3X245_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020362">
        <property type="protein sequence ID" value="VDM31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X245"/>
    <dbReference type="WBParaSite" id="TTAC_0000733501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000733501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000733501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10551821at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000733501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18963" checksum="8C564A0770C83370" modified="2016-06-08" version="2">MDIAKMANRMVSWLTLRRLRWKLRKYFPKAVFDSGGESPDPDRILQSHIERISHFWDSYDEPLLYARNRMGQKDEQGFVLLTEDDCTANGGEQNRAQMTSTPKNLELVNVSPTLPPFVNRIQDEFINQQLTPVERIQVLLNAHVSTAAAEAEECPNALRRYMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2R9</accession>
    <name>A0A0R3X2R9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7590</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020386">
        <property type="protein sequence ID" value="VDM31997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2R9"/>
    <dbReference type="STRING" id="6205.A0A0R3X2R9"/>
    <dbReference type="WBParaSite" id="TTAC_0000760501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000760501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000760501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="58"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="912"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="912"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM31997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000760501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1073" mass="122829" checksum="95C37AE7F52F51F1" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2T7</accession>
    <name>A0A0R3X2T7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7609</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020387">
        <property type="protein sequence ID" value="VDM32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2T7"/>
    <dbReference type="WBParaSite" id="TTAC_0000762401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000762401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000762401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6277957at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000762401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="20445" checksum="4F9C93F40FA17B93" modified="2016-01-20" version="1">MDETELVVPWEKQQRMLNSSNPQPSSPVRKSFSYAGVWQDPGTAQSGVICTDAATAAATAAATAPFTVPHPPASLPSTSEEGLPLTGSLGAQGSSTRKPSSVTDPMTIIFQAGAKMKFVPFFARQGAPPLALSSDGEVSCTFIRPLLGGISRVQVTTGGGEVVLTQFKLLLPMSALCRKRAPPSRSSILVSNAQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3F0</accession>
    <name>A0A0R3X3F0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zf-3CxxC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7857</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020413">
        <property type="protein sequence ID" value="VDM32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3F0"/>
    <dbReference type="STRING" id="6205.A0A0R3X3F0"/>
    <dbReference type="WBParaSite" id="TTAC_0000787201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000787201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000787201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000787201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="406" mass="44503" checksum="F36E6198CC9AD986" modified="2016-01-20" version="1">MRDSHWNPRFVQLSLDLAGRLLSVRASCTSHSVDCWPEAQMTLLTSPGQTATTTSLPFSSPSGQHLATFHLLKQILANSVPLEAVFHSTPFSATTNAPILNNWPQIQQYFSKLRSLIFTSRRTSPPPPLPPPPPLPPPPSLPQSPLPSSALFNPLSMQPSTALPLLLLTQPTQCFLPTSSMPILTAPTPPLLPLTGNLLIDILALTSPLTQVPLQIQPLPTPLTFPQATLHQLVSPLPPQLPLVTNERQAQKNCFNHLQVVCFKDEAKTRFMCLKCSKQWTSMKGAITFVVIMSHQTTPTVEVALAPPTATEEGATWSSQCCVTLRPGANVLLELFPQACADCALHGEVRLSPPKWYPEEVDKFERRALAMPSPGTHLLTNDYVDYSPKVSQVSSKHQVPLKFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X447</accession>
    <name>A0A0R3X447_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS8149</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020455">
        <property type="protein sequence ID" value="VDM32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X447"/>
    <dbReference type="STRING" id="6205.A0A0R3X447"/>
    <dbReference type="WBParaSite" id="TTAC_0000816401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000816401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000816401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="78"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000816401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51455" checksum="8D17351449522BE5" modified="2016-01-20" version="1">MFGVASVSDDAPDKSSGAIKEEAGSAGEISSDDVESVIYRKIEEIRAAQLNSSFSESRTLGCVYPLWPPCPSYRCHPKGLVNTRNTCYLLTCLQTLFGLPPFVAILHHISVAVHSLFAEVGSLRDVWVESHAEMVPLIRLLTLHLDERTPYKPNEVRTGEPILPNDYGYLPTGKPLSLDPKFFTVLNFEVGCEQDAADCMSRIVTQVHEEMATLLRKFRKPEDEDFADDNTDSDGNEGWTTVTSKGKKIREARHVECLEDAFQFLSKGEVISDFKDPKTGLCVVMNRRVFIDRLPPILLIQLKRFFYNPNKGGIQKVLKQIPIYRRLQISDSIVSKERAFSKAQGAYKLKAVIFHIGYNAERGHYTTATVTQSNEVLYYDDLNVFRLGQNEAVWADMFTSHRPFDTRSACCRPLPRISSTAVGADAASERPPNIGEQPRTPYLLVYVSCFQQQSQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4B8</accession>
    <name>A0A0R3X4B8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8231</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020469">
        <property type="protein sequence ID" value="VDM32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4B8"/>
    <dbReference type="STRING" id="6205.A0A0R3X4B8"/>
    <dbReference type="WBParaSite" id="TTAC_0000824601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000824601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000824601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3213154at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000824601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29467" checksum="315B77D5CB2D8DCA" modified="2016-01-20" version="1">MRYRSSQSSDLNSRPFNERRRIISVEWSSLPQEQKEIYYKQAIVERTKYEEVFAEYKKTEEYKRWLARQEYKKSLQRKKNGKSSKEIHDDIDSFDDEYSSKFRRIPIFTHEFLEYNREREMSLRHIRKQVTKLDEETALLREHVNNLASAETSLEQQIKQAEATLASEENVLVKLNKELVATFSDLPVPNSDNSARSPNKGGERINPNNVESYLSRLAELISSGHHEPLKAKARERLKAAMQCGTLSMYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4U3</accession>
    <name>A0A0R3X4U3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020504">
        <property type="protein sequence ID" value="VDM32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4U3"/>
    <dbReference type="STRING" id="6205.A0A0R3X4U3"/>
    <dbReference type="WBParaSite" id="TTAC_0000844801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000844801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000844801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000844801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="487" mass="53587" checksum="E5B7DCEDDB424A7D" modified="2016-01-20" version="1">MSSSRPEERVAIERCIRSFIIKSIQAIVQARSGTAYATACISDVGARNNLMVYLEEDPEIGATIKQNLDSGFPIKMGDTFSLEILMSNGAGRLVVLEVWQFRLDTEDNLLQRAHLPCSKVVANHSGLQPPIYFPTVTSPTVSSSATGVSDATIVAPQCFAVEDFRRSRLFERLASLLKSLLVTTRMLPAYTYSRKQQHEMCYTLRRGEVSFDRLGQGNVICRQVGHLFPGIAVGPNSTHLFLNVSVHYRENLSDIDSEEAPQHLLQSQPHRPRSRRPYIRLAFAPTPEDDDDYLEEEEEEDEEESEGNFTYRIGKEGLPPGEGEAIYDDTTGRCYYCYHDEAENGEAEVTVEDESGHAEDEGETMSSTFVSGEADREVGGATDGGERAPGRMPLHLPFSTVDLDGGTGGGCARMAHLVTELRTKTDLDLFRVPGASANPASSSATASVFDANALGDELAQHEQKLREFDDFLADFTLAVPNVGVTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X518</accession>
    <name>A0A0R3X518_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8522</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020522">
        <property type="protein sequence ID" value="VDM33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X518"/>
    <dbReference type="WBParaSite" id="TTAC_0000853701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000853701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000853701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000853701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14422" checksum="5A4870A4B88262CA" modified="2016-01-20" version="1">MQILCGGVDFPPLSALYQTNQMVCDKADTEKLPITPSPSHFLSPSLSSALCRSANCRDLPPQRYCLGKVQSEGITESPKSIKILVMARLETVSRCYHKAYLLADLSCLLINHSHISSLFFSDPYGPFDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X549</accession>
    <name>A0A0R3X549_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Miro domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8558</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020532">
        <property type="protein sequence ID" value="VDM33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X549"/>
    <dbReference type="STRING" id="6205.A0A0R3X549"/>
    <dbReference type="WBParaSite" id="TTAC_0000857301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000857301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000857301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Miro" evidence="3">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000857301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33696" checksum="FF4207FE20F6F7FB" modified="2016-01-20" version="1">MTGMRLILKIRGGLEVFRSQMKPKCQGVVRILLVGEPFVGKTTLILSLVSEEFSPKVPARSEEITIPASVTPERVPTEIVDFSSRVQTRDQLINEIRQASVICLVYALDDENFMQHLTVQWLPLIRSCFNDSEAKVPVVLVGNKLDLVEESKMEQVLPLMERFPEIETCIECSAKSLRNLSETFWFAQKAVLYPTAPLYHAETKELTPECVCALTRIFRICDVDNDGYLSDKELEAFQERCFAIPLTAQSLLDVKQLIRNSTPGGVTVSGVTLKVLIRLFVMRWHDMQLLKLGLPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5M7</accession>
    <name>A0A0R3X5M7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome non-ATPase regulatory subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">26S Proteasome regulatory subunit RPN11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS8767</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M67A family. PSMD14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020581">
        <property type="protein sequence ID" value="VDM33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5M7"/>
    <dbReference type="SMR" id="A0A0R3X5M7"/>
    <dbReference type="STRING" id="6205.A0A0R3X5M7"/>
    <dbReference type="WBParaSite" id="TTAC_0000878201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000878201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000878201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="560"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="841"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000878201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125390" checksum="1B2119FE589AEBA3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X666</accession>
    <name>A0A0R3X666_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8973</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020642">
        <property type="protein sequence ID" value="VDM33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X666"/>
    <dbReference type="STRING" id="6205.A0A0R3X666"/>
    <dbReference type="WBParaSite" id="TTAC_0000898801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000898801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000898801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="328"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000898801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="663" mass="71906" checksum="4900224E079F841E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X668</accession>
    <name>A0A0R3X668_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8975</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020643">
        <property type="protein sequence ID" value="VDM33670.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000899001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60394" checksum="BBCF28A2A213C119" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X677</accession>
    <name>A0A0R3X677_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8985</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020647">
        <property type="protein sequence ID" value="VDM33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X677"/>
    <dbReference type="STRING" id="6205.A0A0R3X677"/>
    <dbReference type="WBParaSite" id="TTAC_0000900001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000900001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000900001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
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        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000900001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28378" checksum="9F73586231123752" modified="2016-01-20" version="1">MKKPTCEGFWRICQIFFAEMLASGLAHFFCFLVDVSVANLTMVAGFLAGASVYLAIWCTFTTSGAQINPMVTLAVVVTRRLSPLLALVYLVADFVGTLTAMGIAWAISPFKDQEPGTYGMTLPGSGVSSLVATFTEALSTFILLIVILASLDEVRAKEWRPEQGAPFPLAVMLALTINVMLTLPISGASMNPTRSLAAAIIQNNFDRQWIYVAGPVLGTLVACVFYEFVICPFASLNRTRHCLCSSSFDRKERYASEEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6A7</accession>
    <name>A0A0R3X6A7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat domain, L domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9017</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020656">
        <property type="protein sequence ID" value="VDM33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6A7"/>
    <dbReference type="STRING" id="6205.A0A0R3X6A7"/>
    <dbReference type="WBParaSite" id="TTAC_0000903201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000903201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000903201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000903201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7965" checksum="A47A0C740767EA31" modified="2016-01-20" version="1">MSSLRDFYLNDNHNLNNIPAELSQCPLLTILSVENCPLRDLPQPIVSGGSAMIIYFLQQVLQLRRQHTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6S3</accession>
    <name>A0A0R3X6S3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9206</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020715">
        <property type="protein sequence ID" value="VDM33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6S3"/>
    <dbReference type="STRING" id="6205.A0A0R3X6S3"/>
    <dbReference type="WBParaSite" id="TTAC_0000922101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000922101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000922101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133207" description="Small ribosomal subunit protein uS2m" evidence="9">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000922101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27937" checksum="7EE94E7B13BE8D5B" modified="2016-01-20" version="1">MSFILILYALLRRKLLSSLATPPSHSSPVMIDPLQSPDYFGLRDIVSVEQLFNARAHLGHRSLLRNPYMTPYLFGSRQGIDIFDLEQTAELLFDALNFTAHIAYRGGIILFMIQHRQMMHLVEKTAKAVGEYSYCRPWGGGVFTDSTNFYGATTRLPDLIIMLNTVNPVGFDHVAVRDAAKMLIPTVGIVDSNCDPRLITYPVPGNDDSPVTIRHWCGLFAESIAHAKRRARRDDATRKRLASAGGQTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6X7</accession>
    <name>A0A0R3X6X7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9267</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020740">
        <property type="protein sequence ID" value="VDM34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6X7"/>
    <dbReference type="STRING" id="6205.A0A0R3X6X7"/>
    <dbReference type="WBParaSite" id="TTAC_0000928201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000928201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000928201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000928201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="54308" checksum="4F925828985E7451" modified="2016-01-20" version="1">MSLSTLGPLLPNSSEADIIEDIWEYLIPIRGLRRTELELLVPISIIYIIIFALGFFGNAILLWVILVNRSFHTPINYYLVNLSVSDLLILVLGLPHDLYMMWNRYPYPFEEVACRLRAFLAEASMISSVLTITVLTIERYIAIIHPLSTAISGAKRRSGSDSAVRLKKVDFFRCCRDWGRFKKVRITVIIVWILSPLFSLPITLQVALSYIYRNDSSTNYQSVMIKESSICTVSGESEDWFSYPVLASFILFFLLPLVIITILYILILRGVRRSVKFTQNLHPTERIESPTSGEVTVALENVQKPSLRPPAVSPLKRGRSIMFRTGQDKRAARQHQELCQIQQVQHQARMRTNKSLIRILVCIVIAFFTCFAPFHAERLLVVLVPAELWYNNKILWKVHDVLYHISGICLFANSVCNPILYNIVFRRIRAEFKAALMCCGKKRRRQPELYNGRGRSSLYRPSTISQTPKTAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X746</accession>
    <name>A0A0R3X746_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9346</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020770">
        <property type="protein sequence ID" value="VDM34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X746"/>
    <dbReference type="WBParaSite" id="TTAC_0000936101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000936101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000936101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256842at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000936101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18545" checksum="747E8861D010F919" modified="2016-01-20" version="1">MALVCAAKPHRVVLIIAAIVDVICIILTGAGSIHLLVVNMRTLYTAGWLGIVQMVVLIYHCSSCARDADICCKWKALDEVDYSSSTPATVGTAEANCSARSGDAAAPTDPEVGRRQNRRRRRTQSPPPDFRLPDEVPRLPGYDELNKSEGLPPGYDSPRNPPPAFSSTGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7V5</accession>
    <name>A0A0R3X7V5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pecanex-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9615</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020928">
        <property type="protein sequence ID" value="VDM34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7V5"/>
    <dbReference type="WBParaSite" id="TTAC_0000963001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000963001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000963001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000963001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22718" checksum="8BE5CB650FD6D03D" modified="2016-01-20" version="1">MSVPLTTARTLLRRLSLLPETDSGGPHLPSLSSSQNSPTEGAGLASTTIGGSSDTSSALVHACFTGLGLVHFAVAFWTRAWLFRLVLLFASVGLLVYAVASLQLVSGALWLLRQVWISLTTALRSSDFFTTIENGEYSLLLIPPSLRLSLRWARKIERYLYDFIDEYLDYLVSFVIISLMVLISLLFAVFLVVQVSVLPPILNSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Z2</accession>
    <name>A0A0R3X7Z2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9652</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020960">
        <property type="protein sequence ID" value="VDM34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Z2"/>
    <dbReference type="STRING" id="6205.A0A0R3X7Z2"/>
    <dbReference type="WBParaSite" id="TTAC_0000966701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000966701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000966701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="125"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000966701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42959" checksum="C6FDCCAB338A3A8C" modified="2016-01-20" version="1">MCMFDPRNRFSYTNVSLLCAIILLRTQVVINAALYYMHNFYEVFSPETVKPVMVSIASLYLACKTEDFSRKLSLLISVAYSVFKKNAPAESSSTFRRIVQNIHALEGTILMVVGFQKMDVKHPHVILINVLRQNDFPKQVSHTSYFVCTHILHFTTLLLRHSMEAIAATSLYVAAKWNNYDIKSEDGEWYRLFSRELTLEEIRKMADEFTQAFQACDVKIKNQVKNTLKMNFNRHHAREDSVMQARRANESGRVYNRPEKRPHESHNVLNHQQQHVKDMLSSGGGVFSTNGQQLAVSSGVYDDTRSRMKVPRVCSPKSQPPPQIHSQSAFPVATHPDSASALKREEAPKHPDSVGGSYPSVASRSSTTSNARNDLSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X835</accession>
    <name>A0A0R3X835_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020986">
        <property type="protein sequence ID" value="VDM34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X835"/>
    <dbReference type="STRING" id="6205.A0A0R3X835"/>
    <dbReference type="WBParaSite" id="TTAC_0000971001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000971001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000971001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000971001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="521" mass="57928" checksum="F0045373291D38B5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X893</accession>
    <name>A0A0R3X893_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proto-oncogene tyrosine-protein kinase receptor Ret</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021025">
        <property type="protein sequence ID" value="VDM34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X893"/>
    <dbReference type="STRING" id="6205.A0A0R3X893"/>
    <dbReference type="WBParaSite" id="TTAC_0000976801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000976801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000976801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430044at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000976801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="812" mass="91652" checksum="12548BF4083151F1" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8D8</accession>
    <name>A0A0R3X8D8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo segment polarity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9798</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021056">
        <property type="protein sequence ID" value="VDM34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8D8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8D8"/>
    <dbReference type="WBParaSite" id="TTAC_0000981301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000981301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000981301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195736at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01869">
        <property type="entry name" value="BCATNINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000981301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="589" mass="64195" checksum="6C2547E64E89DD26" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8M1</accession>
    <name>A0A0R3X8M1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9881</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021128">
        <property type="protein sequence ID" value="VDM34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8M1"/>
    <dbReference type="STRING" id="6205.A0A0R3X8M1"/>
    <dbReference type="WBParaSite" id="TTAC_0000989601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000989601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000989601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6088000at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027902">
        <property type="entry name" value="DUF4487"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16071">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16071:SF2">
        <property type="entry name" value="FIGNL1-INTERACTING REGULATOR OF RECOMBINATION AND MITOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14868">
        <property type="entry name" value="DUF4487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000989601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34171" checksum="1C01183BC67BF67C" modified="2016-01-20" version="1">MVGCVQHFQSVLFLTTEKFQRRRVMDFISWTLEVQYAGGLFAAGTGLEQNFLKEVSTSLFVAAEMALSCVSQVGPKPGLSISAAVDAIVLADLTPLVNCRIFASIMVNLSKRRDPRAFSMWFSDDFNTYAEFFTNLEAAFALWKPYESIPNPSDFHIPRFLNLSIDHKQLSYAVEQFLTSITIEICRSVRHLPNEIFSFLETALLEATLHASPIISIVAQDIWCFVVRYGSAELCWQYVTLLGNAILCLAERYSSSTSATPLFKAHPPLEQMSRLGYLLSRFLIFLTARQQVGAPVHLMLFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9M3</accession>
    <name>A0A0R3X9M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10233</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021455">
        <property type="protein sequence ID" value="VDM35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9M3"/>
    <dbReference type="STRING" id="6205.A0A0R3X9M3"/>
    <dbReference type="WBParaSite" id="TTAC_0001024801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001024801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001024801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001024801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7854" checksum="3C831240357F3F6C" modified="2016-01-20" version="1">MANLIARHLRTGEVASRQFFLRCPGCTNDRCSKVRHFIAGEAERLRTWTRSQAFRDIAAKITTYNRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Q5</accession>
    <name>A0A0R3X9Q5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10265</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021488">
        <property type="protein sequence ID" value="VDM35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Q5"/>
    <dbReference type="WBParaSite" id="TTAC_0001028001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001028001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001028001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001028001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38971" checksum="8F347684879BC461" modified="2016-01-20" version="1">MQEECPSMTHLSPSPSMQHEQRDDVAIAASSRTASRFFPSLVSGDNHLPSWHKPRVVGRSVWLETGVALVRHPSQCRQMHNFPHLPASQAGLRSEWRTIFRVLQHSSLSLAACSHRCRRACIITDAQSVGVLLGGIVLVKRSGSRYTQRVQFMSEVGGPTEAQSIAFMRMGSLGQCSPVLHTTVDNTPGLCLPHQPAKWHEKDPLAWSGAEPVRAIVSVTEAHPGLKRNPQPTAQGISWPQFHHTPKRARRHIAVGAHASRPDNHMPLHHSPTWTERHMDACLARRWRTAMPNLVTLASMPSGTSGVLVNVRIPPYDSRLHRILLLCRCTMRCRAPTDGRIDTKQCALDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Y5</accession>
    <name>A0A0R3X9Y5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division protein kinase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS10345</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01021576">
        <property type="protein sequence ID" value="VDM35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Y5"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Y5"/>
    <dbReference type="WBParaSite" id="TTAC_0001036201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001036201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001036201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="14"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="20"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001036201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40547" checksum="9F9CBCB0D7D2B9B8" modified="2016-01-20" version="1">MDIFVDETQKNRRYEKVCHLGEGQFANVFLARDLQRGGCLVAIKKATDGMNLSAIREVKLLREIEHPNVMSLQDVFSQDSGICLVFEFMESDLEAVIQDSSVVLTPANIKSLSLQVSYHFALQRFQLLKGVEYLHAQWILHRDLKPNNLFLSPQGVVKIGDFGLARHFAASPGRAMTHQVATRWYRAPELIYGCTRYGVGIDLWAVGCIIAEFLLRVPLFTADCDFSQLDKIFEITGTPDENMWPDVVRLNGYCSFKPRPPMPFSQIFTAAGDDLIALLYTLLSLDPDLRGTATSALASAYFRNRPEPTPEAQLPRPKLSHSVAGTLQQRQRQVIAPIDPASFFDDADLPPTPPPKRRKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAB4</accession>
    <name>A0A0R3XAB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF862 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10474</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021743">
        <property type="protein sequence ID" value="VDM35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAB4"/>
    <dbReference type="STRING" id="6205.A0A0R3XAB4"/>
    <dbReference type="WBParaSite" id="TTAC_0001049101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001049101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001049101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6227366at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001049101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50127" checksum="A0F7C11A562AE173" modified="2016-01-20" version="1">MGLSKLLSQTLVGKQFDGIWHTSVVVYNREYFFSQGGISCCRPGSVQGAQLVERKLVGKTCFSDEDLKKYIDTLSESLFKPGSYELLKHNCNTFSAHLIKHLTGKEIPAYITSLPSDFLKTPLGSTFQGILEGVASAIDPSASGVSTQTGVPLRQSLSSIVRPILFDEPLSTEFSSSELSTMFSGSTGIALQWANSALHYLLKLSSPQLDSVDVPVEALRLLRFNRWATFRQCEAICEVFRLAIWRSPELILTCLTDPDESLHKLADTYPSPTGQISPSNYFDLDAAKSRLLCNVLALSYDWDLTSLPFIPLGSVAALCIRLIRCQDDETESVDKHLAKSPEHEMAGLALAVNFAMCSLIKESEAIDVAASLFYLLTVKKSFKYPYEALYVLKAVYALIGTFSSIADLAKTLEIANYVPELQNQAEHIEGDLDVEESHVDPVKSIADEIISILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAG9</accession>
    <name>A0A0R3XAG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidored_q6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10529</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021807">
        <property type="protein sequence ID" value="VDM35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAG9"/>
    <dbReference type="STRING" id="6205.A0A0R3XAG9"/>
    <dbReference type="WBParaSite" id="TTAC_0001054601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001054601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001054601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001054601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27163" checksum="6750B866101C5BA4" modified="2016-01-20" version="1">MICFKFSEEAVIPDSTSTKRTVAMLSLVLKSRGVCVSKFCPPCALYSSSKSSVPSSLKQPAPNPDHPCEEVSKYKPYSPFRVTPSNKVEYAIARLDDLINWARKNSIWPITFGLACCAIEMMHMAAPRYDMDRFGVVFRASPRQCDLMIVAGTLTNKMAPALRRIWDQMPHPKWAISMGSCANGGGYYHYSYSVVRGCDRIIPIDIFVPGCPPTAEALLYSILQLQKKIKNMKTQQMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAJ2</accession>
    <name>A0A0R3XAJ2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple inositol polyphosphate phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10552</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021850">
        <property type="protein sequence ID" value="VDM35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAJ2"/>
    <dbReference type="STRING" id="6205.A0A0R3XAJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0001056901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001056901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001056901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001056901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30704" checksum="94318B310225D821" modified="2016-01-20" version="1">YTDDNVTITEDFERIRFFADCNNYISAVRSNKVAKKEFYKFRDGKEMQQVLREVVSDHGLQDLQLTTTDIANLYKIAAYEVAAMEDGSPLPGWVQLFRPEHLYVLEDGYDVSKLKRESSPRSVFWFGHAETLLPLVTKLNLFNESVSSEFGGGEHLTAAGFQSRLKRLQLEDLPVTNLFRSSHIIPFAGNLVFYLFYCPNLDGERQEPSLNDYCLEVRLNEQVVEIIPQAEGLSRPLRLPQVLAHFESCLPSVYNKTALCDQPLSSPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBE1</accession>
    <name>A0A0R3XBE1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10850</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01022364">
        <property type="protein sequence ID" value="VDM35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBE1"/>
    <dbReference type="STRING" id="6205.A0A0R3XBE1"/>
    <dbReference type="WBParaSite" id="TTAC_0001086801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001086801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001086801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="8">
        <location>
            <begin position="276"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001086801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40563" checksum="8B370DDC0F72C3FB" modified="2016-01-20" version="1">MGRLRALQVRCDFRHTMQALILIGGYGARLRPLTLSVLKPLVEFCNRPMLMYQIEALVKVGIKTIILAINEDAACLESEIRRMCKMVVKNLVIKKSGVNVIFSYESEHLGTAGPLANAARLLCESEEPFYVLNSDIICQYPFKKLMEFHKSHGKEGTMAVTKVKEPSRFGAVVFNDQSGAVQRFVEKPLDFIANKVNAGLYVFNPSVLRRIQLKPTSLELDVFPPMVNDGELYCIEISGIWMDIGRPKDFLLGMQMYLEHLRNKGCLEHRDLPDFIGNVLIHPSVKIGIHCVIGPNVTLGPDVCIGDGVRIQDSAVLSGAKVRSHSRLEGTIVGWNSDVGRWVSKGTVTFALFVCNYEVLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCE9</accession>
    <name>A0A0R3XCE9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cadherin_C_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11209</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023210">
        <property type="protein sequence ID" value="VDM36189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCE9"/>
    <dbReference type="STRING" id="6205.A0A0R3XCE9"/>
    <dbReference type="WBParaSite" id="TTAC_0001122601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001122601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001122601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001122601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21788" checksum="947A854489CC4224" modified="2016-01-20" version="1">MNVSKNLNPQVFADPALQPDTNYTLFAFVASSLYDVKDEVEEGDFVVSPKGTKVVRTMPLSTTWSSGTAVGAVGTGIAVFFSLICILLLALFVWWRYLGHQSVLWQKSKQYSLNMRPGRLSETITPSSVEDCMSAMPNSYRSWSFPLNLRDPRFLVIDPERGPDNTLLGTKDLREIAETFYREYKRLVNEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB9</accession>
    <name>A0A158REB9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-related protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7034</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020340">
        <property type="protein sequence ID" value="VDM31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REB9"/>
    <dbReference type="STRING" id="6205.A0A158REB9"/>
    <dbReference type="WBParaSite" id="TTAC_0000704901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000704901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000704901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38906" checksum="19CD3F44EC40779C" modified="2016-06-08" version="1">MAPQCLVIDLGGGSIKFGLSSAKSPRCVDNCIYRSKNVPGRNFIGSEIEECKNLSSLFGIYPFKKGYINNWDTQKQILDGVLCRYINSSSADMQSLNLFVTEPYFNFTSTKETMNELFFEEYHVAGLLRANPAFFAAYRYRSGSSQRPSRYSLIIDSGYSFTHILPMVDGNIMKEFALRLSVGGKILTNRLIEVTSYRQLDVRSEVYIMNQCKEDACFVSTDFWADLTCAKSHNPSINMLAREYVLPDYIDVHRGYLRSLSEKPKDAVDRTKLQGYILRLSNERFTVPELLFHPTDVGYTEMGISEAVQHLLTERLPPGVRPGAMANVLLIGGNSKFSGYKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REI4</accession>
    <name>A0A158REI4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CNDH2_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7350</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020364">
        <property type="protein sequence ID" value="VDM31716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REI4"/>
    <dbReference type="WBParaSite" id="TTAC_0000736501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000736501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000736501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5859781at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1183"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1214"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1317"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1344"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="933"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000736501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1428" mass="156574" checksum="D66E4F46885821BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REL1</accession>
    <name>A0A158REL1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7513</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020379">
        <property type="protein sequence ID" value="VDM31907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REL1"/>
    <dbReference type="STRING" id="6205.A0A158REL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000752801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000752801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000752801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000752801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52491" checksum="842996DA3642CA6E" modified="2016-06-08" version="1">MPRDLITLQLGQCGNQIGMEFWKQLCTEHGINPEGTLEEFATNGTDRKDVFFYQADDAHYIPRAVLVDLEPRVINTILSSPYARLYNPENVYMSKNGGGAGNNWAAGYTQAEKLQEEIFDIIDREAEGSDSLEGFIMTHSIAGGTGSGMGSFMLEHLNSHFPKKLIQTYSVFPNLEDTSDVVVQPYNSLLTLKRLTLNADCVVVLDNTALHRIATDRLRLENPSFAQINQLVSRVMSVSTATLRYPSYMNNDLIGLISPLTPTPRLHFLMTGYTPLTTEKEVAEVRRTTVCDVMRRLLQPKNMMVSTSVQRNVDHCYIAILNIIQGEVDPAEVHKSLQRIRERHLVKFIPWSPCSIQVALSRRSPYVQTAHRVSGLMLANHTSISSLFLRSLNQYDRLRTRGAFLEQFRKEEVFRGDPELRQFSESRQVVQHLIEEHLAATKSDYVQWGAQKAAAAAAAASAALASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ECE6</accession>
    <name>A0A3P7ECE6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000771">
        <property type="protein sequence ID" value="VDM18963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ECE6"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="86" mass="9742" checksum="52183DBD7214E394" modified="2019-02-13" version="1">MLMALLDIKSKEELASVVETRHWKLLPPDADAKDNEEWIFITNHEASVKSTNIKEKVTFDAMARSAHAFKPSVGRFFIQAPDKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EPX3</accession>
    <name>A0A3P7EPX3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004833">
        <property type="protein sequence ID" value="VDM25240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EPX3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="173" mass="18963" checksum="21F1F99A49291D71" modified="2019-02-13" version="1">MLPPLLSPQVKLRKVDADDDAAVVALVSTGGTAHKKEGKEMEKFVSTNTMATQHCGQEGDAFAFIPPFLPIPSVSTSSLSFLQPLFLLSPASPSFSILTPLFPLLVFFLLSSSTDSLSNIRHIAEPTRILLRLLPLRLQGTPMKGNDGIEQHINNPIALHDHPCTTWFLIFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ETE2</accession>
    <name>A0A3P7ETE2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication factor Dna2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006793">
        <property type="protein sequence ID" value="VDM26581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ETE2"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="114" mass="12252" checksum="C98BDF975510D3A2" modified="2019-02-13" version="1">MIPCSIGNKPTTTSSFSTWSLSDDPLPSDVTIPPLLVLHPEVLISGTTVAAAARGCVRRAVLQHFWDKDRASSTVMEPNSDSATSKSLTEGGVMLLGSLVHKVFQQVIPMIEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F4P7</accession>
    <name>A0A3P7F4P7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003109">
        <property type="protein sequence ID" value="VDM23477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F4P7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="51" mass="7254" checksum="9675254D4ADAF2A4" modified="2019-02-13" version="1">MWWRWLRLRWRRLRLRRLRWLRLWLRLRWLRLWLRLRLWLWLGLRLRCRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F4R0</accession>
    <name>A0A3P7F4R0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 20</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell cycle-related kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cell division protein kinase 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS3869</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01003193">
        <property type="protein sequence ID" value="VDM23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F4R0"/>
    <dbReference type="OrthoDB" id="63265at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000406">
        <property type="entry name" value="cyclin-dependent kinase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="290" mass="33030" checksum="8544596995012C99" modified="2019-02-13" version="1">MMSFHPNIVRLREVFPHGMGFTLVFDYMSTDLSEILRSIDSPLSEGEVKAYMIMLLRGISFLHSNSIMHRDLKPANLLINSKGILKIADFGLARLFSRQEDKLYSHQVATRWYRAPELLYGARRYTESVDLWAVGCILGELINNSPLFPGENDIEQLWFVIRVLGTPTEKNWPGLTQLPDYNKITFSHCEPVALEDVLLSDSLLARNLLGKFLCYDQNRRISAEKALLHDFFLTEPLPVGHNMLPKPKAKRNTSTVLENCLKAPLSTLIPSPNFFDETAKNITTFDDTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FP43</accession>
    <name>A0A3P7FP43_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021694">
        <property type="protein sequence ID" value="VDM35413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FP43"/>
    <dbReference type="OrthoDB" id="10333878at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="158" mass="16747" checksum="2975115664008BF0" modified="2019-02-13" version="1">MLHSLASVAPADANQGQIPASSEHFVKDLPNSLSEASNQVQPESHLATSQSRNILGETHMLKQVNGTSLSPSAYIGTPKPCAILPRYLADLVKQASVRSCKFTGSSGDSGVSSTSTSSSLNYHETLALRVRQRAPAMGCGSPTPPRSASLLEKYTREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQE9</accession>
    <name>A0A3P7FQE9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022407">
        <property type="protein sequence ID" value="VDM35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQE9"/>
    <dbReference type="OrthoDB" id="6271830at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="161" mass="17921" checksum="3F677372FC749CAA" modified="2019-02-13" version="1">MAERVAAEEAEKNFQARLECWNHEIELSTMSLVKQLESLLTYESPGWLVDAAVLHHDATISGEIDVTGMFGSAALEPDEIVAEDAEEGDEGLGIAGLGDSPHSRRLQMIILRETCLRDVVFMLVKVFKLTGRHDDCVRLADLVADPQFGIFKTNLYRNMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GFC6</accession>
    <name>A0A3P7GFC6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS2910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001666">
        <property type="protein sequence ID" value="VDM21488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GFC6"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone H2A C-terminal" evidence="8">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM21488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="210" mass="21924" checksum="FB4EEC3ADA4AFB78" modified="2019-02-13" version="1">MITALGHFPTHTTAGMSGRGKARKPAGGKKHTKSARAGLVMPVGRVHRYLKLGRYARRTSTAASVYLSAVIEYLVAEVNELSGNAAKANKRLVRVALSLFIILISSFFKIKTITPRHIMLGVRNDAELNELLKNVHISHGGVLPCIHPSLLKRKSYSDSLMATSHSGAGGAVINPLPVTNATAASSASARVLTSASTAAGTASSGIASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HL38</accession>
    <name>A0A3P7HL38_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="UYWX01021290">
        <property type="protein sequence ID" value="VDM35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HL38"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="653" mass="75015" checksum="7820B92FF4002B18" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HL63</accession>
    <name>A0A3P7HL63_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021693">
        <property type="protein sequence ID" value="VDM35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HL63"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="1">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="183" mass="20880" checksum="116919F9397EF883" modified="2019-02-13" version="1">MLASKPSSTLPISSLWKQTLEEFGKWLFEVLSPDNDSSRNLVPAPYNLPFYEVFYGPTQEAEIMALTRNLNPPLIKSIQDALCNTDCFFPIADHFDSTVLDLCVAYKIYRESSSLINVYDWLIAFDAILEPSSAPADTGPSRLIRSRFLRALLDLEQMGLVRRTKRRRDHAQKMPVMEVPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHT1</accession>
    <name>A0A0R3WHT1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Expressed conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS119</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000008">
        <property type="protein sequence ID" value="VDM15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHT1"/>
    <dbReference type="WBParaSite" id="TTAC_0000011801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000011801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000011801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6265041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000011801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14910" checksum="901E3B23D0E53F0B" modified="2016-01-20" version="1">MVLHYRSVSSADTGAVAAGRVEMSCRDIKKLVRKVEDDNQPLQTESTAKPITFACAKLCLKEMLDIYDYLGPNCSINDSKKEVEKPIQAMPPCKYGHYRDLHAPCSTSNQTSQRTQQSQQSCQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI16</accession>
    <name>A0A0R3WI16_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS211</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI16"/>
    <dbReference type="STRING" id="6205.A0A0R3WI16"/>
    <dbReference type="WBParaSite" id="TTAC_0000021001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000021001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000021001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1188"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000021001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136387" checksum="7DE5699B4A09D91E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI32</accession>
    <name>A0A0R3WI32_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS231</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000015">
        <property type="protein sequence ID" value="VDM16109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI32"/>
    <dbReference type="WBParaSite" id="TTAC_0000023001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000023001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000023001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6234466at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000023001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41651" checksum="70EC17B80670EA4A" modified="2016-01-20" version="1">MGNSALASRIQYQRRFENTAVQENPLTLYERVGDPRWKIDHADDKVRHSCKQKLNDSNKLSIEGITRKPLSPVKEQPNSRQEESQSDRDVNTMPVDSVSTIIVDQPHPIPVITVTHFGDQDTAKTTSKVHNSPPRVLKTPPAAQIKNQPGLTGVPRHKPIQRLSQTSPTKARSQTPRRTNSATPRPERSQSTKHKSAVRAPRQDRALAKTLPHAASNSSIRNREPKIVQSGTLHRECDRLASPLNCKRSSSAGPYSRHPTPMNTPRRAVSRDVPKRAPGLPQSRLEYTFYIRDTDEHRRPFDENTADAIARSCQCSIELITLGKGFPPIFHKGVRVCPVTITTSNMTNLRRCLAKLDAHYPEFNAKAFLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIM1</accession>
    <name>A0A0R3WIM1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS457</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000040">
        <property type="protein sequence ID" value="VDM16479.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3WIM1"/>
    <dbReference type="ESTHER" id="hydta-a0a0r3wim1">
        <property type="family name" value="OtherNon-catalytic_C"/>
    </dbReference>
    <dbReference type="WBParaSite" id="TTAC_0000045601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000045601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000045601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="63"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000045601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="603" mass="68408" checksum="9842281202530260" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ67</accession>
    <name>A0A0R3WJ67_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000080">
        <property type="protein sequence ID" value="VDM16860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ67"/>
    <dbReference type="WBParaSite" id="TTAC_0000069701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000069701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000069701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000069701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9813" checksum="047AFBBB743F27F5" modified="2016-01-20" version="1">MSSHFRPTGSASRPEYDAVKHWSQMPGNEQIVVCVCVPLPSEHPKEEEDHRLQSIAFVIGTAAAGSIGSFIEKSFAEVIDSIGEIICDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJJ7</accession>
    <name>A0A0R3WJJ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFAP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM17072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000084601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000084601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000084601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000084601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20443" checksum="1A1FC7739A94BACB" modified="2016-01-20" version="1">MKRPKDDSDVSALSEDDDYVPYVPLKERRKQKLYAVRQALGNLAYSEPTESDHEEAAIVTENIAEKKTPDGPVLPSTTLGQTNGEADGQETAGPKAKGSLFDTMWELKKQAEEKRETERDKKLKEEALILNSVTEKTALKGVGEIAMGIHYDKPIQTGKAGLKPMRFELDAIGGGQMDQQEWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK07</accession>
    <name>A0A0R3WK07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1034</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000162">
        <property type="protein sequence ID" value="VDM17347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK07"/>
    <dbReference type="STRING" id="6205.A0A0R3WK07"/>
    <dbReference type="WBParaSite" id="TTAC_0000103301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000103301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000103301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6271797at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000103301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="773" mass="83135" checksum="B833B112DE1A8330" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKM9</accession>
    <name>A0A0R3WKM9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1274</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000244">
        <property type="protein sequence ID" value="VDM17730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKM9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKM9"/>
    <dbReference type="WBParaSite" id="TTAC_0000127301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000127301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000127301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000127301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18854" checksum="9C3A9D5B8FD7B0DF" modified="2016-01-20" version="1">MNTICRCNPDPTSCANKPHFVRMDLDEKVESYFLHIVYEACQCYTDPVDLCTAIKQCLDQKFGPMWHVVVGPEFGSKPHFLRRSLDPNVESDFLYYVRQAYQNYDDPEEMCTALKTRLDEKYGPTWHVIVGDYFGSHFEHEPKGFCYITYQGLSFLMFKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKZ9</accession>
    <name>A0A0R3WKZ9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B14 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1413</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000301">
        <property type="protein sequence ID" value="VDM17955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKZ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WKZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000142601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000142601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000142601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="14">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000142601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14443" checksum="EA7CFB8A96C2F827" modified="2016-01-20" version="1">MSAAGSFKVVRPILSRNAVEAKRRVLNLYRAWYRQLPFIVKEYGYTCVTATVPELKQKLREEFMKNKDVRDIRVIDLLVHRGQNDLLEVARTWRSDCQVMDFFRETEVEKPKDFLTKFLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH6</accession>
    <name>A0A0R3WLH6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1601</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000398">
        <property type="protein sequence ID" value="VDM18271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH6"/>
    <dbReference type="STRING" id="6205.A0A0R3WLH6"/>
    <dbReference type="WBParaSite" id="TTAC_0000161401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000161401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000161401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10508545at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000161401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8711" checksum="1EA0545976930494" modified="2016-01-20" version="1">MGRVRRFTLSQINTEGMQHPLVLAARRQSVNLSSTGIGEDSRLSSQYRLGGIGSLEEEPEESVDDDADDDGDDESEDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLS1</accession>
    <name>A0A0R3WLS1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1696</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000453">
        <property type="protein sequence ID" value="VDM18410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLS1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLS1"/>
    <dbReference type="WBParaSite" id="TTAC_0000170901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000170901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000170901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000170901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="976" mass="107596" checksum="75CB9596D3A2DDD3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNA2</accession>
    <name>A0A0R3WNA2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intraflagellar transport protein 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2227</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000866">
        <property type="protein sequence ID" value="VDM19299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNA2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNA2"/>
    <dbReference type="WBParaSite" id="TTAC_0000224001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000224001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000224001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000372">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM19299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000224001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="554" mass="64584" checksum="83F5255684C2B15D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP57</accession>
    <name>A0A0R3WP57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2532</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001179">
        <property type="protein sequence ID" value="VDM20377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP57"/>
    <dbReference type="STRING" id="6205.A0A0R3WP57"/>
    <dbReference type="WBParaSite" id="TTAC_0000254501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000254501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000254501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000254501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21051" checksum="F6937BF9F348F9BF" modified="2016-01-20" version="1">MDDELGTEVEISIACRNLADTDVLSKSDPVVVVFEFCPALEDWREIWRSETIQNNLNPNFSRKLVLQYHFEEQKKLKFAVYDVDDPNEPLRHQDEITFNISAKNLDKKDIIGLSDPFLAFYRLHENGSVTVAHRTEVIKNTLNPSWSTMILPVRLLCNGDLNRYVLHFSLKFLHSLLRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPD0</accession>
    <name>A0A0R3WPD0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS2605</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01001275">
        <property type="protein sequence ID" value="VDM20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPD0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPD0"/>
    <dbReference type="WBParaSite" id="TTAC_0000262001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000262001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000262001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF222">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="61"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000262001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31739" checksum="C9D07A28EFCC8F90" modified="2016-01-20" version="1">MEPTAVTNNGLQLESQMKSPHQTSSPRHCGADISPPNQGQSKGHESRGQRSSNTHLLFSRYEKLSKIGEGAYGMVFKCLDTQTGDMVAVKRFNASDDDPLVKKIALREIKMLKRLKHPNLVNLIEVFRRKKKLHLVFQYIDHSLLHELDSNGPNGIDRDKIVRITWQILLGINFCHQSNCIHRDIKPENILINAQGEVKLCDFGFARFIADAGDTYTDYVATRWYRSPELLVGDKHYGPPVDIWAVGCVFAEMLTRLPLWPGRSDLDQIYLITKNLGATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPK0</accession>
    <name>A0A0R3WPK0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FERM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2675</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001367">
        <property type="protein sequence ID" value="VDM20852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPK0"/>
    <dbReference type="STRING" id="6205.A0A0R3WPK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000269001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000269001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000269001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000269001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12214" checksum="EB8228FD5205D14A" modified="2016-01-20" version="1">MSLVLGADALGLSIYEPDNLLNPKVGFPCPEIRNSFHGKAFIIQPAEKTAKEFYISVEKSKINKHILALLTGNHELYMRRRKFDYRSVVDEGTGKTGRELKEEHLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPL6</accession>
    <name>A0A0R3WPL6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2691</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001383">
        <property type="protein sequence ID" value="VDM20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPL6"/>
    <dbReference type="STRING" id="6205.A0A0R3WPL6"/>
    <dbReference type="WBParaSite" id="TTAC_0000270601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000270601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000270601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249223at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000270601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26236" checksum="56BCC0A38A1B2169" modified="2016-01-20" version="1">MAATFKPRLESDLSDTVPQGQNHHSRYCGGYQCIKTNGTLTHSFSTEDGQMAIANRGYKMDHNKEDEVDDASPQLEDVEALIRGYSHSHKLEDEDEVLEGDGNVNDCDDYDDDDENVINGSSPILLSECPEFQAYLQPLQVSSHEDNPILNDEDEIVFGFVPLKNKNLSPQNKEERDNESVLWELIEAEAEALCLSEKGIACCQRNAVAPSPTKRTSGHNLSKVGANNFSTYLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPT5</accession>
    <name>A0A0R3WPT5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2760</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01001481">
        <property type="protein sequence ID" value="VDM21096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPT5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPT5"/>
    <dbReference type="WBParaSite" id="TTAC_0000277501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000277501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000277501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000277501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29251" checksum="E83BC2B44D3C63E3" modified="2016-01-20" version="1">MIYTHEDVREIVEFARVRGIRVIPEFDIPGHTRSWSLSHPEIFAKCYDAEHESPFYGGLDPTKNETLEFLGALFEEILELFPDNTLHMGFDEVEFNCWSSNPGIKKFMLNNGIESPIDILKIFTVRLLNKIQEAAKRVSMTGQRRFIFWQEAFDNGLKVPNNSLIHLWKGLSSMPGYFGFQVIVSKGWYLDSYLKPSEWVGYYENEIYSPRLYPDVYSDFEPKNVIGGEACMWIEWQSDETVIQRIWYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPZ8</accession>
    <name>A0A0R3WPZ8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2823</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001552">
        <property type="protein sequence ID" value="VDM21251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPZ8"/>
    <dbReference type="WBParaSite" id="TTAC_0000283801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000283801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000283801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2339771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010561">
        <property type="entry name" value="LIN-9/ALY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045831">
        <property type="entry name" value="LIN9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689">
        <property type="entry name" value="LIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689:SF2">
        <property type="entry name" value="PROTEIN LIN-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19438">
        <property type="entry name" value="LIN9_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIN-9 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LIN-9 C-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000283801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30256" checksum="B7EF859B404247D4" modified="2016-01-20" version="1">MERILAKKQKAVAVLREMNEAVEFQVPNEPSPVTPEFQHKYATLILHLDELNQELKYHINIVIRHITEVRPLLKTPPPINADGYVPHYRDHEFHVSMPSRQCSVLPVYESQEVIDTLPISGGSCDVAREYGMQDVLVTDWRRRCEDEAYEIVNRLKASQGSSTVDESKFVLVAKLTTILTLLSHLQENRMSNSELSCIEEVFTDIRQHLHPSNLKCFEQSVEQLISHIVLNLSPSIIPMSTPNTSFIPPNSNTNPTEPHYPGHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ79</accession>
    <name>A0A0R3WQ79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2904</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001659">
        <property type="protein sequence ID" value="VDM21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ79"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ79"/>
    <dbReference type="WBParaSite" id="TTAC_0000291901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000291901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000291901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10465751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000291901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="248" mass="25720" checksum="52FBBFE141A3D5D7" modified="2016-01-20" version="1">MVLQPATMQNQFCSRAATVSTSGVSLLPPPPPVPQPQQQRQPNNTTAGFSQPILQTGYISVPRGEETTSLFHAPTNGICANSQFATAEDANANTNATTAANSGFIELVPANGVDGSGPILSTGDLSKWIRSGTSTAKVIGGRVSTGQQIFHQQACLDSANSAIIRLPQAASRAPASQQQQHQQQQLLFLTASNGATTAAATNPHTSFSNVATIVQQTTGLDHNRGVWTANSTTTGTTVTALPNPTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQH1</accession>
    <name>A0A0R3WQH1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2996</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001784">
        <property type="protein sequence ID" value="VDM21706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQH1"/>
    <dbReference type="STRING" id="6205.A0A0R3WQH1"/>
    <dbReference type="WBParaSite" id="TTAC_0000301101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000301101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000301101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="64"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="11">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM21706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000301101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="38189" checksum="B341AF014F6DB7CD" modified="2016-01-20" version="1">MSKAKRRRLDFPEVKGWVPYKPFSKNSSFAAFDEKSERVDVPEDWKEPKFSPEDNPNGRLYSLSTFSTLFPQYREKYLREVWPAVVKILREHFVKAELDLGESTMSVRTTQKTFDPFIILKARDMIRLLARSVPFDVAARVLNDEIFADIIEIKLKNRERFIKRRNRLIGDEGNTLKAIELSTECYVMIQGKTVAAVRQVVNGCIYDNIHPAYYIKRFVIIQKLMSDPNRKNISWEKFLPSIKKKTLSRRRKPRKVRKKGEYTPFPPPPQPSKVDIELEKGTYFLAKAEKRRVKKEAKVATSEETSRRRQQEKRAAAFIEPEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQH4</accession>
    <name>A0A0R3WQH4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2999</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001788">
        <property type="protein sequence ID" value="VDM21714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQH4"/>
    <dbReference type="WBParaSite" id="TTAC_0000301401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000301401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000301401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6225202at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000301401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55252" checksum="DF208A464AC09E89" modified="2016-01-20" version="1">MDDSVNDCLSSMQERLFGFYKEGKLTDITWAVGAEGCETEYISAHSSVCALSGRLKELMLAHSNDQLKSCIRVPPSLTLIPSDFRCVLHLAYTGTFAEGHSFEQCLRLCELFEMPLGIDACLSGLKNLLTELLIRPSIDSETQNGLRDFFINSINDSKMKSVHPIILNFFRMHPLIFDSKLIPSIANSSLFIAEPCLSKVPVEWVIELLKKGKLWMQHPDGFVYFGGKYMSEAAQFVERLCTAHNMEPLEVQIARTRSMLAPLRVSTFVSPPFGYHSTYAYGYNYSELEGRHRTHDNYPPNEWKIAALTGYITRNWDGRQVLAGLDITYRNFETGNEEVVEWEHQNEEHYTVQTVFVPEDDVIIGFEINCGWLIDRVTFTTRKGVRLNQLGTSDGGNRTVFDGSSLARVNAGEWSDDEQTERSDRDDVIVSLHGISYKEILSRRQLLWNKVVFHFASIDRSLVETLNPEHGPIMHQILKDKQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQL4</accession>
    <name>A0A0R3WQL4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3039</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01001835">
        <property type="protein sequence ID" value="VDM21803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQL4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQL4"/>
    <dbReference type="WBParaSite" id="TTAC_0000305401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000305401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000305401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132938" description="small monomeric GTPase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000305401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30972" checksum="4DA562926C8C0FD7" modified="2016-01-20" version="1">MGGGGGGGVGVLCDWALPWSRLLAVIDSADAYLVVYAIDDRESFKGAQTIISEILGRCKIASAIVLVGNKTDLVRARSVSYDGEWLSSLLTGHHAHVVLRPSIPSSTSTFITTSTHPLFTHLPFAASTALHCIALVVHSTGHRHRVELMHDMKPPTPNDGCQCAPRECFRLEHLRRVDEKWKVCGMNKAIHQPHRNRATAIYVAVHLHQSDFPSLTALLLLLLRPLCLLLSHPPSTHPATTSRSCTTPPQLHLLQCRYASTIAQDLSLTLTLHTLLQPHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQR6</accession>
    <name>A0A0R3WQR6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3091</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001911">
        <property type="protein sequence ID" value="VDM21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQR6"/>
    <dbReference type="WBParaSite" id="TTAC_0000310601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000310601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000310601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264476at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000310601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49140" checksum="5F7D03C914ABCE62" modified="2016-01-20" version="1">MSTNTATAKHKHHKERISAEFKSDGVVEGRVPIKPQDEVDIQGAREVLEMRSHRNLGKAYKVKVIGTDTRLIIKRKSVVGSGQRELSLLCNEVYRFFIFARDPKLVILVVPDQSEGKRAYLLLKMKSESDANRVCNVIQSGRKRLNSQAPLPAQPEATSPGQSRASESAISEEPEVEMQENGKSVDKPSSYEVEEGNDHSEDEESEAASESTTKSIHTRTPDTSPRTISPRKASETESKPEVNEIAVHSTPEVRSAFPAMLNPRKPESEKEDDEEDTSPRTLPRTPLHSGPPSTKANKKKQQHRREPPRIEEMYVEPPKNWKVAQPICARREEELREALLVDMYDDDWAVDVKLIKTDGGFGSRLSDSGNVYMFTAHHLVPENYSYFECSSSSDEEVELREKPMRRVNRPTNSGIGRRISSSSESDRRNSYAGMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRF5</accession>
    <name>A0A0R3WRF5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002257">
        <property type="protein sequence ID" value="VDM22408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRF5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRF5"/>
    <dbReference type="WBParaSite" id="TTAC_0000334501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000334501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000334501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10667528at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000334501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14394" checksum="C1A8E7F78DF19E9C" modified="2016-01-20" version="1">MLGSCGIKNCEDVLDGGALTVCAERTEIAKGPMGGHRPPLELAMDVQTVMESSSGTPPSMVDAKKASPVSPSSHSWPSVSSEISKSSICVQNPTLALDESEERLNSGQMEIFTDSIQPNTDGIYFCHLCEYTGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRX6</accession>
    <name>A0A0R3WRX6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS3500</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002538">
        <property type="protein sequence ID" value="VDM22757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRX6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRX6"/>
    <dbReference type="WBParaSite" id="TTAC_0000351601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000351601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000351601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM22757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000351601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38353" checksum="7861B0CC464CDC4E" modified="2016-01-20" version="1">MADFDEFKMDLKIERVTPSDEGEYICLYRGEKLVHEKHVYLKVLAVLKGHTLNAVPPFINPNGSSNTRVVVREGLTQKLICNVSGVPAPTVKWYVSTTDGKARRVITAKDQPRFLLSISALIISNVTRDLRGVFTCVAYNGIEGKVSRNIHLDVYFRPVVKMSAEVIYRKPYQTTMIFAIVIGNPIYSLYWEFDHKPIRSVNGDCFFTLSGDKYCVVSDRETANPMTVRTKLTIYNLTLDDYGTYTCVVHSPFGMERGSTKLVQKLKINTLSLIFFFPVKPDETKFFPTLWNPSSWRASQGEYASQQTPKAATSGEPKKFLSLFLNVLIGVNAYFLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSC1</accession>
    <name>A0A0R3WSC1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3647</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002798">
        <property type="protein sequence ID" value="VDM23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSC1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSC1"/>
    <dbReference type="WBParaSite" id="TTAC_0000366101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000366101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000366101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273936at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000366101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14322" checksum="0A4992C4E25210EB" modified="2016-01-20" version="1">MAGGDWICYGVDWMRFFQPSVFQFFLLLTMSLLLRSLPTAVILIKGHRYRRLPSLFLGSALFGTLVGCLVCLGGYLHTADNLHTCLVITLVTAFLLGVWLWVATTPGGGAAAVSLGQGRLRLVIALLPSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT72</accession>
    <name>A0A0R3WT72_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3947</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003340">
        <property type="protein sequence ID" value="VDM23825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT72"/>
    <dbReference type="WBParaSite" id="TTAC_0000396201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000396201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000396201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674273at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132979" evidence="1">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000396201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26606" checksum="E66CD119BF44C67D" modified="2016-01-20" version="1">MDVIKKAFCLIILQSAVAFWPTTDVERRQILEAHHRARESVKPPASNMKLMMYSKKLENLAARWASRCVFEHPDRNTYPEYRELGQNLALAAGFTPNITEAACGWRSEIKFYDSVSGRCRHVCGHYTQMIWASSSALGCAMWRCDGVRPDWHNPQYITACQYSPPGNYIGSKPYIQGRSCSRCSPGEQCYRNQCARNARHNQVYPLAKFKSPRYRSLPPCKLPQSYSTFEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTG1</accession>
    <name>A0A0R3WTG1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Malate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS4036</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01003529">
        <property type="protein sequence ID" value="VDM24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTG1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTG1"/>
    <dbReference type="WBParaSite" id="TTAC_0000405101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000405101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000405101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="171"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000405101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="227" mass="23825" checksum="7B76650851D2CA29" modified="2016-01-20" version="1">MKFLRSISVIVGWSAKRFSTSAQNPQKIAILGASGGIGQPLALLMKQSVFVSDIALYDIANTAGVAADLSHIETRARVTGHTGPDNLKAALEGAKLVLIPAGVPRKPGMTRDDLFSKNASVVAELSRACGKYCADAMICIITNPVNSTVPIAAEMLKKEGAYNPKNLFGVTTLDIIRSNTFIAETKGLDVAKVSCPVIGGHSGNTIIPVFSQCTPSVSFPQVGTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTQ1</accession>
    <name>A0A0R3WTQ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4126</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003724">
        <property type="protein sequence ID" value="VDM24239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTQ1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTQ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000414101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000414101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000414101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="43"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000414101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39925" checksum="4205729D1DA36E95" modified="2016-01-20" version="1">MPSDACAPFTKLQSEKAGIIIKHLESGYDLQCLKFWSLSRYGLVNDAVRRKVWPILSGLEGSNSENPHSNALYDLRDLLSHPQAKQVELDVRRMGSMIPKCLSSDESERLITETKRLALSILAEYPDLHYYQGFHDVCYTCLAVLGPDEAFAVLKQLVPKHFDVFMQETMDATSETLQSVFDLLQLTSPEIWFRFRALNFEPFFTLSWFLTWFTHILSDSNDIHRLYDLFMASEPSMLIYLSVSVIICSTEEISSTSDDFGELHHALTHLPMKHDVEKLIQCALDIYLKIRPEKLLEKAEDRRKAGHTARKSSRSSPTLVLVNQRLFFCGAVAVLTMGLVWHHFFSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTU9</accession>
    <name>A0A0R3WTU9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4174</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003833">
        <property type="protein sequence ID" value="VDM24358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTU9"/>
    <dbReference type="STRING" id="6205.A0A0R3WTU9"/>
    <dbReference type="WBParaSite" id="TTAC_0000418901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000418901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000418901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM24358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000418901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11841" checksum="871FCC59D6A1DA23" modified="2016-01-20" version="1">MAMLKIVGRQILDSRGNPTVEVDIITYRGLFRASVPSGASTGLHEACELRDNNPQEFNGLGVKQAVRNINEIIAPALLKKELLVTQQAEIDSFMVNELDGTPNKSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTV0</accession>
    <name>A0A0R3WTV0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS4176</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003840">
        <property type="protein sequence ID" value="VDM24361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTV0"/>
    <dbReference type="STRING" id="6205.A0A0R3WTV0"/>
    <dbReference type="WBParaSite" id="TTAC_0000419001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000419001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000419001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000011">
        <property type="entry name" value="Aryl hydrocarbon receptor nuclear translocator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM24361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000419001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="38840" checksum="1F68894FD4469702" modified="2016-01-20" version="1">MTNDQHICEGGNCNGCTQPDKEETFAQLEKERSARENHCQIERRRRNKMSAYINELCAMVPSCSSVSRRPDKLTILRMAVSHLKTLRGATNISDGYLKPSFLSDQELKHLILEAADGFLFVCRCDTGKVMYVSDSVSPILNATQSDWYHRTVYDLCHPDDADKIREQLIGVQRTSSCAALGLDSPHESLTNGADYNKSTDSSTGCITSRVLDLKSGIMKRDGSAKSRCGLSDDRRGFICRMKLGSPLPTQASPSASTVARQARLRHQQIVLSAADSLNGDIGDFVAGPLQQRYALMHVTGFVKSAPPAVGSPSTVNAEGFSIAHSSTDFVTSLLGMLFCASTPYFIPFIGMNARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVI9</accession>
    <name>A0A0R3WVI9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005265">
        <property type="protein sequence ID" value="VDM25599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVI9"/>
    <dbReference type="STRING" id="6205.A0A0R3WVI9"/>
    <dbReference type="WBParaSite" id="TTAC_0000477901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000477901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000477901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249493at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000477901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16850" checksum="CB5A8DA0EA102269" modified="2016-01-20" version="1">MSVGKDSGVGLFDVNLVSIMMMGMWVLVLTWELQVTLLLSWNSMSTECRFVGLTSEFVNEGLLKVPSLELLRDRSLVACRSQLILKCSGKFRLISIPSSLNARFRRAGGLVDFLRFLRTQVAFVFRPSLPSMSSAFVALSNLRALFPVGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVL3</accession>
    <name>A0A0R3WVL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCDC92 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4787</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005328">
        <property type="protein sequence ID" value="VDM25643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVL3"/>
    <dbReference type="STRING" id="6205.A0A0R3WVL3"/>
    <dbReference type="WBParaSite" id="TTAC_0000480301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000480301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000480301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12083">
        <property type="entry name" value="DD_cGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000480301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19956" checksum="A1205BF5D7ADFB90" modified="2016-01-20" version="1">MAFAKEGQSSADLSTVHTPASPTTAKPPHNLAARLRNLAFHFSRSSSMLESKRNPPLSSSPASPSHGSNHNNTKIEHDVGVYQEQIQKCEGIIADLRKQVTLKDKQIAYLSSELDKYQSVCNQKTQILGRGRSWGVKMEVRGTKSEPDGGRRKRGIGISAEPRALQLGENEQPKHYPKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW96</accession>
    <name>A0A0R3WW96_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ski_Sno domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5021</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005975">
        <property type="protein sequence ID" value="VDM26081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW96"/>
    <dbReference type="STRING" id="6205.A0A0R3WW96"/>
    <dbReference type="WBParaSite" id="TTAC_0000503601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000503601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000503601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000503601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28178" checksum="954F5649D6797013" modified="2016-01-20" version="1">MEPLNALTTLVRKPSAQIADISSSSQASTVLCNAFDFEVCPSVFKLYTYIRSHPLVVRHLRLVDESDEIQNHLRLLDRRLYFRTAYHYNTIGCPALTLEVLSRLPHLPPADVVRTDGRKVDLPVPDSKNSSGGAELTFFEPNEDARALVSDSDFKVVWSDEEDEEEKCGDFAEVTDSSSNLSSTIKSTTFRHSATPGNSVSNHFLQNVDDDAHFTRSFEVHFSVSASSTLVSHGSVIDSNQRLAEISKSNSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYI4</accession>
    <name>A0A0R3WYI4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Growth-regulating factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009155">
        <property type="protein sequence ID" value="VDM27704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYI4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYI4"/>
    <dbReference type="WBParaSite" id="TTAC_0000582401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000582401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000582401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000582401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23270" checksum="763B848CA8930F30" modified="2016-01-20" version="1">MTAEARGCLPSDSHSVALLQREPSRSGSGGEVQRLLKGVECSGDLTTLILNSSSVSTPTNTTSNQGCLKGHGLPLTAGVPYLTGVGGFQSSTQSGAYNMINSLPGFSTESPNGQLVQYDTQWNDSQLQNSAGSRTEALHEVPPYASSNVVSPEMNQSTWNSAIEVPMKMHLANQSNTLDKHSCPIRLMPSLASIPYIANGPFLLSYSLLVQVNLVFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZK2</accession>
    <name>A0A0R3WZK2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6215</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZK2"/>
    <dbReference type="STRING" id="6205.A0A0R3WZK2"/>
    <dbReference type="WBParaSite" id="TTAC_0000623001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000623001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000623001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000623001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9492" checksum="97EF2758711EE8E2" modified="2016-01-20" version="1">MGEATTFSLEEVKKHNSENDCWIVIHDKVYDVSKFLDQHPGGDFVILESGGGYATESFEDVGHSEAESSLKFSSNYSRDRKPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZX0</accession>
    <name>A0A0R3WZX0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TTAC_LOCUS6360</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 24">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZX0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZX0"/>
    <dbReference type="WBParaSite" id="TTAC_0000637501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000637501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000637501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24814">
        <property type="entry name" value="WD40_Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VDM30554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000637501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56231" checksum="2CBB3144691CBACA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZZ7</accession>
    <name>A0A0R3WZZ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nkap_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6395</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZZ7"/>
    <dbReference type="STRING" id="6205.A0A0R3WZZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000641001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000641001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000641001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="227"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000641001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38718" checksum="C2EDD437BB626A7A" modified="2016-01-20" version="1">MSTGIRYHSSHHRDRSRSPFGESRRSRHRQRSLSPFGNEFKRPSGDYYNQHSRRYKPFEIGYQTPEFWQNRRQAREDAGASTNRKIWGPPPEEPYTDSGEDEYFEITREGPLPPSTPPLDQKVEKGKKGENMTKKSRKHKRHHHHRHHHGKGKKKKHHHSSSNSSSSNTSSSSADSEEDEARSFIRQMKAKKAELERRRQEEEEATEIIGPVLPGANGADSTNQRIDYGKALLPGEGAAMAAYIAEGKRIPRRGEIGLTSEEIEKFEQVGYVMSGSRHHRMEAVRLRKENQIYSADEKRALESFNHTERAKREAKLQAQFKALVKKKLEDKQNVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0J4</accession>
    <name>A0A0R3X0J4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6640</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0J4"/>
    <dbReference type="STRING" id="6205.A0A0R3X0J4"/>
    <dbReference type="WBParaSite" id="TTAC_0000665501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000665501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000665501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000665501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44208" checksum="BCE3C767048F26C6" modified="2016-01-20" version="1">MVCHDDTHFCNGQKECDHRVPLVLIHGFASGVGLWCKNFDTLSASRRVYAFDLLGFGRSSRPPFPDTAEEVEDKFVEIIEEWRKNINLEKFILLGHSMGGFIASSYALSHPERVVHLVLIDPWGFTGQEESNSAYPSGVRGWVARKLASFRALTTMRMIGPFGLNAMRKVRQDFGHVYFQTSASTNGPCEVDDEHHNFERGDSWPPDKKQNTASRLIVSKASRFDSLSPYDSSVVYNYIYHINVRNPTGEDAFKSMSVLGWAVRPMLPRIQALKVDVPITFIYGGRSWVDFSSGFTTHDLRPNSYVDVMVLRVVLKLLYPASLTMQVIEDGGHHAYAEYAEEFNNYVNTIARLVDEGYVFQPGNEDVVQAAAASSYHSTSSPVRTNGSQVQASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0N2</accession>
    <name>A0A0R3X0N2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6691</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020316">
        <property type="protein sequence ID" value="VDM30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0N2"/>
    <dbReference type="STRING" id="6205.A0A0R3X0N2"/>
    <dbReference type="WBParaSite" id="TTAC_0000670601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000670601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000670601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="386"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="592"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000670601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115281" checksum="9B435CA2D3992C88" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X142</accession>
    <name>A0A0R3X142_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nanos-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6875</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020328">
        <property type="protein sequence ID" value="VDM31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X142"/>
    <dbReference type="STRING" id="6205.A0A0R3X142"/>
    <dbReference type="WBParaSite" id="TTAC_0000689001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000689001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000689001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10010129at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="9">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000689001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29053" checksum="892A87E27783EF54" modified="2016-01-20" version="1">MPAGSLLWGAFSPSRSVSPGSVQVSQSPWHLGNASPQQNQGYGERYSLAVEQINRWRDLWLVSSISKFLGLCTQNVDAPSTFIPLWTLYCFPRIKSYYEQGIPMDNPLLYRLTNFLGQLILLIRHLCEANMDLCVFCRNNNETFEMYTSHKVKDRAGRVICPVLRRFVCPLCSATGDYAHTIRYCPFSSHNAAASVGFGMRPPNSTITTAHHRIFEAPPTTTSFDGGVSRCVNMDDNSDGGRRLIDQLMLETCRSLSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1V2</accession>
    <name>A0A0R3X1V2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="15">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS7202</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="15"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020353">
        <property type="protein sequence ID" value="VDM31543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1V2"/>
    <dbReference type="STRING" id="6205.A0A0R3X1V2"/>
    <dbReference type="WBParaSite" id="TTAC_0000721701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000721701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000721701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000012">
        <property type="entry name" value="Blast:Putative inositol monophosphatase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0452">Lithium</keyword>
    <keyword evidence="7 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM31543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000721701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36225" checksum="D5959912A18242E3" modified="2016-01-20" version="1">MEPPFIMKLMASSVSIATVAGSIVRRVLASGKLDIVDKGVNDLQTQADRSAQHCIVSSLSKRFPGICIIGEEDLGDSEQPYSELVEGTDSSVLAKSCPQTLESTNVDDVVVWVDPLDGTSEFAQGFLEHVTILIGVSVRGRAVGGVVCQPFYMADFRRVIEIAGEQERRPRVEETHQRVIWGLEGLGVFGLAGEPIAKAPIFSSSTSDDERANCIVCTRSHTTPTAAAAVESCSPSKIYRLGGCGFKMLMLLEGVAHAYVYASVGCKRWDTCAPEALINAIGGRVSGVDGRAYSYASHVHPVDGRGVIATPTAAWHSAYVERIPRSIVNTLCASAPPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X224</accession>
    <name>A0A0R3X224_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FRA10AC1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7293</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020359">
        <property type="protein sequence ID" value="VDM31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X224"/>
    <dbReference type="STRING" id="6205.A0A0R3X224"/>
    <dbReference type="WBParaSite" id="TTAC_0000730801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000730801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000730801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000730801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="25246" checksum="ED879CA072AA5A29" modified="2016-01-20" version="1">MVNDYLQYYGGSRKDFKRDTTNDKRDIDVIKANARFVWEDRDNPDTWEERLAKHYWDRLYKEYAIADFSRYKEKKLGLRWRSEREVVLGKGQFVCGSVDCNEVEYLRSWEVDFAYNERGEKRNALVKVRLCPTCSQKLNYHKQHSEVTLNVGHKEPAEENKVLDQHESQELTSGGDHWKEPSTSNQQGSDRHESQRTQEDEFDEYLRNMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2J5</accession>
    <name>A0A0R3X2J5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7497</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020378">
        <property type="protein sequence ID" value="VDM31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2J5"/>
    <dbReference type="WBParaSite" id="TTAC_0000751201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000751201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000751201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17536at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16094">
        <property type="entry name" value="PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000751201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28182" checksum="91397AEA22E2B330" modified="2016-01-20" version="1">MATLFPKKVPAFTRALGGNDDIFDSETDLPVEAEVAVTFSVNFNQRISVLVFGIGAAQCEVLSANIDFSKAVKMRVVDLTVSNQIVMSCSAFMFDQKIVIWLCDTQERDSCYGFRKWVDTLLSSFLLDQNSCIYILTDSPASEFQSDFKPSTPFIRTLRTPRASGLCFPDVKPLEPPNIIAGFASPIMAHCIYHSLPACVLIVYYENLRTSLAKTDIFPVLIPILAAIGELRPFILSDGISGRPTAHNFDQMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X338</accession>
    <name>A0A0R3X338_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7723</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020398">
        <property type="protein sequence ID" value="VDM32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X338"/>
    <dbReference type="STRING" id="6205.A0A0R3X338"/>
    <dbReference type="WBParaSite" id="TTAC_0000773801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000773801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000773801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000773801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39131" checksum="7B12AD2DEFE8D2AB" modified="2016-01-20" version="1">MADRLTELQDAINLQAENLGNAVGVIQQLAQPSLFRELNHNGRREKEWASNPEFQALLQNQSQEDNAHKFAVAIATTAKQIDLLISSLPAEEASLELQDEATRHLLSDYRKESAKLVHLITKSFQTRLSKVRQLLSKIAEVQLLTRTLENEVSRILWSDLVAAIIVCRFVGILLPILVPKLATHLIPSCRAHCRASQLRYQEVRDLRKKMSQLNMVDNFAVYSKLERKVKALDRQQAESDRSHLGTKLVCSLFAQCVRYILHGILLAWLAYQAPRERLSDEQLALLYETRALVGSLVHWIHYVPSWVITMLWIPLCEATASLLLSKVQRCIEGEEDVMVAPAACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X355</accession>
    <name>A0A0R3X355_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YccV-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7741</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020400">
        <property type="protein sequence ID" value="VDM32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X355"/>
    <dbReference type="STRING" id="6205.A0A0R3X355"/>
    <dbReference type="WBParaSite" id="TTAC_0000775601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000775601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000775601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053189">
        <property type="entry name" value="Clp_protease_adapter_ClpF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48439:SF1">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="2">
        <location>
            <begin position="125"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000775601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29375" checksum="0EF9A5D54EAAF532" modified="2016-01-20" version="1">MPLLDDDRVHLFIILLLIPLQFIVWNYIHASQVDTEPIFKPSIYFKSNPFFLFNYLKNATVKIYQKGIAGILSLKLKDLFVLPISLRSNKPALPPPPPPKIIELYERNHVFFGANQRVHQTRPPSLRFSVGQVVRHRLGFKAVVIGWDEVACAPASWMVLRYPRLERELEARQQPNYRLLADAKDTLFQLGPVYVTQDELESLSVEELKSETRGLYPHEPIIKHPIIAEFFDFFDGKKFSPRPWLRRIYPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X377</accession>
    <name>A0A0R3X377_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7768</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020403">
        <property type="protein sequence ID" value="VDM32222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X377"/>
    <dbReference type="STRING" id="6205.A0A0R3X377"/>
    <dbReference type="WBParaSite" id="TTAC_0000778301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000778301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000778301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM32222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000778301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23097" checksum="5649AA493958E8B0" modified="2016-01-20" version="1">MILFVSATTNPLSHYWIQGAVPRIRTAFEKALGTSSSSNPMLRFGGTSGEMPCLALTMTPSFWTDHLRIVLWSAYMAFEWTLAGVSASSTSTPANDFDAHRKQRSAFKAIFYRAVEDLPWAKASTVLLFFFMLSESRMFPSVLTMHLMEVTVKVIDVSLFQVLYTDLARYCPEDAEEVVDLLTSKGLRLRTFMEEVDLLLTSKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3N5</accession>
    <name>A0A0R3X3N5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dynactin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS7956</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020425">
        <property type="protein sequence ID" value="VDM32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3N5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3N5"/>
    <dbReference type="WBParaSite" id="TTAC_0000797101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000797101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000797101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000797101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44195" checksum="D801D039337D6B42" modified="2016-01-20" version="1">MSVDPKFANMPWIAHDEPDVYETDDLPEADQRKSESNDVEQVLPKEIERISISAIKARHRFEHCKVDASNVDFSDKISGTGKVGYAVESPEYESNINGEKESTLTARFQRLQAEVRQLIDDAEAVKKEAGSVATEGELSAEQISTLATSLISQLNELQLEEIFGSDLDLTDLCVHDVLLQKRLYEQIANFRPKQSLQKDGAPGERITFELYSKPSDKTDAAIEKTLELDRRLQRLETIVGTREITAMGACGLMETAARLSERVLLLQPSYLDQIEARISTMQAKLADITKNPENAAIADADTQNKIAELFEIVKKWNSFSADLPSIVDRLKDLQTLHAQASEFSTSLVNMEVAQRRIDDSLAAYGSQLRNVQESLLNALSTFKENTMAIEKALKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I4</accession>
    <name>A0A0R3X4I4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS8309</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="3">Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020482">
        <property type="protein sequence ID" value="VDM32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I4"/>
    <dbReference type="STRING" id="6205.A0A0R3X4I4"/>
    <dbReference type="WBParaSite" id="TTAC_0000832401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000832401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000832401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="586"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="795"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000832401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="950" mass="104633" checksum="23669C134C94DD1E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4L0</accession>
    <name>A0A0R3X4L0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dual-specificity kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8339</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020486">
        <property type="protein sequence ID" value="VDM32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4L0"/>
    <dbReference type="STRING" id="6205.A0A0R3X4L0"/>
    <dbReference type="WBParaSite" id="TTAC_0000835401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000835401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000835401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="440"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="937"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="962"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000835401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="986" mass="106416" checksum="C8ADC50A9DFB78E6" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5H8</accession>
    <name>A0A0R3X5H8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">B-cell CLL/lymphoma 7 protein family member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8706</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020567">
        <property type="protein sequence ID" value="VDM33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X5H8"/>
    <dbReference type="WBParaSite" id="TTAC_0000872101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000872101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000872101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5989898at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000872101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14614" checksum="802D7A63F1FD641E" modified="2016-01-20" version="1">MFARALRAETRSRARDDTRRVHKSTEKVQRWEKKWVPVKDTSMLIYKWVPIAEDEHAQPKKSGFARAQANVLAPTGGSIITMSSCPPELRTVESAPSESTPADRVPKIETPGEISNDAKDGLTVDTPVDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5R9</accession>
    <name>A0A0R3X5R9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEK_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8814</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020594">
        <property type="protein sequence ID" value="VDM33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5R9"/>
    <dbReference type="STRING" id="6205.A0A0R3X5R9"/>
    <dbReference type="WBParaSite" id="TTAC_0000882901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000882901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000882901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000882901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="6710" checksum="409D016C8EC28029" modified="2016-01-20" version="1">MPVVTAQGPAAGTGETVPAPAETSPSPQSPATTTSSNQNSNAKIQEQVKVVINDLAKKLHGKTTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X662</accession>
    <name>A0A0R3X662_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8969</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020641">
        <property type="protein sequence ID" value="VDM33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X662"/>
    <dbReference type="WBParaSite" id="TTAC_0000898401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000898401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000898401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6264453at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133200" evidence="2">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000898401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9285" checksum="FB9000A8E3AA2CF4" modified="2016-01-20" version="1">MSILCFLLVAFSHFASAVTLKEGMEDKEKYIFYDTSPFNVGLHAGLALLITYGILGTFTPSVMIITKALEKRRKRRTRTMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6H2</accession>
    <name>A0A0R3X6H2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9089</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020676">
        <property type="protein sequence ID" value="VDM33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6H2"/>
    <dbReference type="STRING" id="6205.A0A0R3X6H2"/>
    <dbReference type="WBParaSite" id="TTAC_0000910401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000910401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000910401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000009">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000910401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49622" checksum="C6C33669FCBFA508" modified="2016-01-20" version="1">MASSNGETMATQADKNVEMWRIKKLIKSLEAARGNGTSMISLIIPPKDQVTRVAKMLAEEYGTASNIKSRVNRLSVLSAITSVQQRLKLYNKVPPNGLVVYCGTIITEDGKEKKVNIDFEPFRPVNTSLYLCDNKFHTEALNALLTDDSKFGFIIMDGSGTLFGTLSGNTREVLHKFSVELPKKHGRGGQSALRFARLRVEKRHNYVRKVAETAVQLFITNDKVNVEGLILAGLADFKTDLSQSGMFDPRLQAKVLKIVDISYGGESGFNQAIELASDTLAGVKFIQEKKLIQRYFDEISQDTGKYCFGVDDTLKALEMGAVDSLIVWENLAVTRYVLRSSSSDEKRVIHLRPEQERDRSHFIDPETQTEMEVEESQLLLDWLALNYRSFGAILEIVTDKSQEGSQFVRGFGGIGGILRYQVDFQHLAGGDLDFDEDFDLDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6M4</accession>
    <name>A0A0R3X6M4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9149</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020694">
        <property type="protein sequence ID" value="VDM33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6M4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6M4"/>
    <dbReference type="WBParaSite" id="TTAC_0000916401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000916401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000916401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22383">
        <property type="entry name" value="KH-I_Hqk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="96"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000916401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="540" mass="57608" checksum="7C3B4B0CCE697B84" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6S4</accession>
    <name>A0A0R3X6S4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9207</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020715">
        <property type="protein sequence ID" value="VDM33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6S4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6S4"/>
    <dbReference type="WBParaSite" id="TTAC_0000922201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000922201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000922201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6228084at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000922201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26413" checksum="16424D1E16CC0AC3" modified="2016-01-20" version="1">MPYAACKFIEMGNIADVAGRLRTGSEPQRVVMLGLDAAGKSTILCSMNLGNNTAPKPTIGFNVDEVHIPGTRVSFVVWDLGGQESLRVIWRQYLQGISGLVFVVDSADVSRIEEARSCLHALVRDAHLAGVPIALVANKQDLADSLSVSQVEELLDMGRLSPIRNPYIVRPTIALSGVGVTQLFVDFAKLVRLQEKRWAAYNRRNSAASSASDDSLIRRSWKARFSARVPHIFRRSGETPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X774</accession>
    <name>A0A0R3X774_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9379</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020788">
        <property type="protein sequence ID" value="VDM34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X774"/>
    <dbReference type="WBParaSite" id="TTAC_0000939401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000939401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000939401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979034at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="17"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="207"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="375"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000939401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54323" checksum="35DFE5485E951C1A" modified="2016-01-20" version="1">MQNWKHGPTESDNMINPLKNISLTPLSHDKVNVSWKSLDGEDTTDVYIAYAKGSAGKSCRGVSNDANCTIGGLSPLTTYEICVIAFIPSFALNIAYTFEDLHIRCRISNYFPCFLVADKRLMNILLGIFIPLFIILLLILLFVFRNRIACVRDLFGGKSPASDVEPALFSIEYCDPPDPKSTANVPPPIPITRFGAELQVLNGNNGFQSLFQTMGGIAISEVEDKYQLTRRAALKNGSRNRYCDMIPYDQSLVMLGRPWSTAVKDPKPQFTVSEVEEGYINASYVRRPEYGSGGEAMVASITCLPEYIATQGPLQSTVADFLTMCGGKXXXXGEETFGNVIRRQLKIHPSSEASPWTVTQFHFMGWSDYGVPDMESFYSLITMQNNFLATHHVGDEYGPTVVHCSAGVGRTGTFIAARFLLDRLRNNPQNVDIVGTVLAIRKWRRSMVQVPLQLQFLYNFVNFCIEKKNIDVKSTPLRPTLPPTSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7E1</accession>
    <name>A0A0R3X7E1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9451</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020824">
        <property type="protein sequence ID" value="VDM34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7E1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7E1"/>
    <dbReference type="WBParaSite" id="TTAC_0000946601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000946601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000946601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000551">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="229"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000946601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="683" mass="74110" checksum="7DA94B8909291313" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Z1</accession>
    <name>A0A0R3X7Z1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020960">
        <property type="protein sequence ID" value="VDM34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Z1"/>
    <dbReference type="WBParaSite" id="TTAC_0000966601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000966601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000966601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252446at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000966601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24103" checksum="F01F05FC79DA7CD2" modified="2016-01-20" version="1">MPIVEALEPDPEFAMTFKNLFDTVHFRSFAQLQEQFTRFYEITGACYIRRHTTKLPHNHADCGTCVYRRLTLECKHSGTFRSRSTRGVSRKSKMINCPSRMNFIYDNGFLRLLNYNLRHNHLLSPVAIPRNEPCNVVPKRRSHLRHPSSKYEDRVPPEIAPNAFWQTEPALVSGTSDEINPLVAVSSELPLHSSKLRQLMSEMRDRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X850</accession>
    <name>A0A0R3X850_HYDTA</name>
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        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 14 A</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">TTAC_LOCUS9710</name>
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    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TTAC_0000972501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
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    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="50"/>
        </location>
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            <begin position="262"/>
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    </feature>
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            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000972501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="554" mass="63061" checksum="A2C1C67CFA0B4E01" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8I5</accession>
    <name>A0A0R3X8I5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Four and a half LIM domains protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9845</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021103">
        <property type="protein sequence ID" value="VDM34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8I5"/>
    <dbReference type="STRING" id="6205.A0A0R3X8I5"/>
    <dbReference type="WBParaSite" id="TTAC_0000986001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000030">
        <property type="entry name" value="Four and a half LIM domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056807">
        <property type="entry name" value="LIM_FHL1/2/3/5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25076">
        <property type="entry name" value="LIM_FHL2-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="165"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30527" checksum="A9D82BBA001AE281" modified="2016-01-20" version="1">MTGAESGENFQCTKCEKSLVGQRYILNSEKPYCIDCYDANFTNTCAACGERITSASKDLSFQDRHWHEACFVCMECKTSLADRPFATKEEAIFCPDCFDEKFAARCDGCGKTFKAAMRKYEYKGGAWHEECFLCAECHQPIGAKSFIPRGNDIICVQCYEDKFAQKCAKCEAVREPLVFGICSTSSLNQHNFSCSSVNTGADRVINKSGITYKGQPWHKECFLCANCGSQLAGQKFTSKDDKIYCADCYSELFAKRCSACSKPISGTYFSGNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J1</accession>
    <name>A0A0R3X8J1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9851</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021111">
        <property type="protein sequence ID" value="VDM34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8J1"/>
    <dbReference type="STRING" id="6205.A0A0R3X8J1"/>
    <dbReference type="WBParaSite" id="TTAC_0000986601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF9">
        <property type="entry name" value="UNCOORDINATED 115A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HP" evidence="2">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25829" checksum="CB281C136624ADCC" modified="2016-01-20" version="1">MYACAVTAPSRESQRSSVSPHRLDHSLDLVNLGNRVWTASDRHRCRHDGTSSRKTISTMHVYPSHFTLPISIPSAHFLSPPCFTPGNSTSLRPGYTAGQLSLSSTKTSSIGGSHCFSSPRLDTSQANGHTNGKVSEDAPVQSQTSPIRRNGHRVNDEASNLSQDFDTSLLGSTPSYPSVVCSTPYTMSVKLEGSSAKMYLSDSEFEKVFQLSRVAFYRLPEWKRNDLKRRVDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8S2</accession>
    <name>A0A0R3X8S2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021170">
        <property type="protein sequence ID" value="VDM34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8S2"/>
    <dbReference type="STRING" id="6205.A0A0R3X8S2"/>
    <dbReference type="WBParaSite" id="TTAC_0000994701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000994701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000994701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000994701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15175" checksum="D310CF48660CB1A7" modified="2016-01-20" version="1">MTAYRGYKGGPVGYGDPDDRTIGDTERGTLFSKFVKERLMFDLCEREWRHWRSCIRAHKDSLVPSRKCKLEFALVNECQNTLVQDPEQMKKFEEEYLQRRAEFRRTGVGVCYLTKEMLRKPDVGTDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8W6</accession>
    <name>A0A0R3X8W6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021207">
        <property type="protein sequence ID" value="VDM34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8W6"/>
    <dbReference type="STRING" id="6205.A0A0R3X8W6"/>
    <dbReference type="WBParaSite" id="TTAC_0000999101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000999101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000999101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000999101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12160" checksum="046EE444CCCF7257" modified="2016-01-20" version="1">MSSRHHHHCHSKKGSEDPCDARAKFVSKDLHEKNETRFLEVVQTACQLYDDLVDLSTAIKQTMDETYGPTWHVVVGPNFASHIMHEKSAFAHIKCNNLSFLIYKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X957</accession>
    <name>A0A0R3X957_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021285">
        <property type="protein sequence ID" value="VDM35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X957"/>
    <dbReference type="WBParaSite" id="TTAC_0001008201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001008201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001008201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001008201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15661" checksum="91369FCB22142C64" modified="2016-01-20" version="1">MHATLLGQAGVLQTEFKDTLLKDAFAGYEQWRILTRVSRSEVEQSLFQLPAQWANVARSTITGAVGLTMLLAFDLIHGYCQSRDYTTTREDSSMQWICHFDSTLPPPLVCPHKIQQRLSYEADGKEEENAPPCLAANGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAU4</accession>
    <name>A0A0R3XAU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10654</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021997">
        <property type="protein sequence ID" value="VDM35634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAU4"/>
    <dbReference type="STRING" id="6205.A0A0R3XAU4"/>
    <dbReference type="WBParaSite" id="TTAC_0001067101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001067101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001067101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001067101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27679" checksum="8CBEABEA0AE4876C" modified="2016-01-20" version="1">MDTAVLCLAFSRDSELLASGSMDGKVKIWRIQSGQCLRRFEKAHTKGVTAAHFSMDNVQLLTASYDHTIRIHGMKSGNLLKEFVGHTGFVNDVVFSPDGRHVLSGSADGSVRIWSTRTAECVSNCKTISGLVGREVPILSVQLMPRNADQFIVCSRSNTIAIMNMQGQVIRSCTNGKREGGEFVGLTVSSGGEWIYAVCEDRLLYCFNVSSGGKLERTLPVHEKEILGVAHHPHQNLIATFSEDGLLRLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAV6</accession>
    <name>A0A0R3XAV6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10666</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022015">
        <property type="protein sequence ID" value="VDM35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAV6"/>
    <dbReference type="WBParaSite" id="TTAC_0001068301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001068301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001068301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6263945at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001068301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14628" checksum="A1F6A18DBBC10588" modified="2016-01-20" version="1">MLCDTPDLPDTLFPLDSLGNSSSPPSPPHHSCKKSYRSPSSHRIHHVADADRQSKKRKLNRDAAYRYRQKVKMKNGMLQDELNSAIQAFKEARNMYEFSRSAFDALKKIVLDMGVIDAPSCHQTHSILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB59</accession>
    <name>A0A0R3XB59_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10769</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022214">
        <property type="protein sequence ID" value="VDM35749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB59"/>
    <dbReference type="WBParaSite" id="TTAC_0001078601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001078601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001078601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133357" evidence="2">
        <location>
            <begin position="34"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001078601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30173" checksum="1A971554B075AA74" modified="2016-01-20" version="1">MWRRSETTGFEVTPSLRLFSLLLLYQDLLGVHSHPSKISYTLPPPLSISLSSMSVTLGDSVTIRCHINSNSEGGTLMAQSSMTLYCPATPRDTFCFQNCRPQEVCNGNGGCRVIPALEGVTCRSIIHSSGEIVYEYTLVHVTPEWVDTQHPGFACHSAAGQTGWSRLSVKTEDALEKNGNKATSPPPPKTTTTSTTTTTTSTTTTTTTTPEPRKTTASHDKTSNETKAVIMSSSNVGDDSVQWLKFLRNSSSGTCESTLPILNYCVFNLARILALLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBL3</accession>
    <name>A0A0R3XBL3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022536">
        <property type="protein sequence ID" value="VDM35904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBL3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBL3"/>
    <dbReference type="WBParaSite" id="TTAC_0001094001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001094001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001094001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001094001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29731" checksum="2A2C6551CF121C75" modified="2016-01-20" version="1">MNSKALLTKRVRDVRIDVHPFEQALVICYKAEATILGESGDPVIGDKKECATKSPANEALADPGAFDSAKIDETANMADLDEYLDLLYEDTTEQLRSSALILQLARNPDNLEELFQNGTLCMSILERETQTYASWMEDLRQLRIAQGEDCLEYKQNAERCGDLIRKQEQLLRVAIYLLLNLAENVEVEEKMHRKGIVALLCRCLKRKNHDLVVLVVSFLRKLSLFQENIDEMDLLGMEFRAARQALPSAQQQQRRRRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBM6</accession>
    <name>A0A0R3XBM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022571">
        <property type="protein sequence ID" value="VDM35916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBM6"/>
    <dbReference type="WBParaSite" id="TTAC_0001095301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001095301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001095301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001095301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16894" checksum="1AC27183AF4F40C0" modified="2016-01-20" version="1">MAQLGVFHDAVILSEWILKVLAIMALQTVSIVTFNFSAFYQSSQSFDLMQITVTTKRNLKLAMCHKTGHVSIANPSQPQTMEPTSTGMNMANHRTPSRRLSLVLPTTDLCARLYSLSVGLSTRSVILWHDAFGPNASADACPSGDSCYVSGVDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBP0</accession>
    <name>A0A0R3XBP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Syntaxin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022595">
        <property type="protein sequence ID" value="VDM35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBP0"/>
    <dbReference type="STRING" id="6205.A0A0R3XBP0"/>
    <dbReference type="WBParaSite" id="TTAC_0001096701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001096701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001096701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283009at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049538">
        <property type="entry name" value="PCN-like_spectrin-like_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21020">
        <property type="entry name" value="Spectrin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001096701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19865" checksum="BA019CFBD5BEF6FB" modified="2016-01-20" version="1">MESQFSSFQSIDINSELKRWMAQLEVVETGVNNLFGQVQILRNGRYIRTEQVYRKVCTLHQRLLELQRRCRNFLKVTSLSQSEDRIQTLRANGGSWTAAPGGRSSSSLRWLVKQSKHFGVLQAALDWIQERNETIANAPFGDNRKCKHKALAVPKLKQLLRQNTLKKFHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBY8</accession>
    <name>A0A0R3XBY8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11048</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022804">
        <property type="protein sequence ID" value="VDM36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBY8"/>
    <dbReference type="WBParaSite" id="TTAC_0001106501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001106501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001106501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001106501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15230" checksum="6C49544834781273" modified="2016-01-20" version="1">MKECGLLNGAVAGSECMQATRGREAALPRVVREELVVREMTSEVAQHGSGRGSQASRMNDGGEGCEVEATAAAAAPPPPPPLPPLLQRTHFLTPPSHSILLLSATVHPPTHSLHSISPPHPATSHNASLYHIDGMSRTGAIVECPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC02</accession>
    <name>A0A0R3XC02_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022836">
        <property type="protein sequence ID" value="VDM36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC02"/>
    <dbReference type="WBParaSite" id="TTAC_0001107901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001107901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001107901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285352at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001107901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33612" checksum="B6BFD1DE0570637A" modified="2016-01-20" version="1">MDGVSSLEELMECNSYVRGRFLSCQNRLFVILWGSFQKAISGLARLYKEKLDNRCDNQCLLQALYRIESFYQMSQNLLKYAKNFGITLGYNCRRLLLRDALFSSSSNDLCAYDVYAAVLQPFIVGGVLTHGHKRKRVQRCKRCFKRRRRLSIKRCCVISPENERKINQVMQPFLNHYDLSTSALDGHGNWTVSISGFSSPAPPALGNWRSFLSTEAAASVDTLELIMPSVNELQLPLSPNQSLILSRRKRRLGFTDDYHPYSLIDSMSKFCLHSNSKIQCLESVIDADIREDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCE0</accession>
    <name>A0A0R3XCE0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LBH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023191">
        <property type="protein sequence ID" value="VDM36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCE0"/>
    <dbReference type="STRING" id="6205.A0A0R3XCE0"/>
    <dbReference type="WBParaSite" id="TTAC_0001121701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001121701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001121701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001121701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18217" checksum="608A1A8DFA6291FF" modified="2016-01-20" version="1">MMMQRSVDNSEMPAQVFMSPYWSCEVNPQVDGDFLDELIYLWPYSRRLMSPLPEGEEEDEDSSEAELKEVSGPSKDVITPFDWSAASARIDKILPTESEESPRLPGMTTVILSQEILTPRMETTDTYHKDANSLPKGSIESVVEKPVTSSLRCDTVVVHFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD07</accession>
    <name>A0A0R3XD07_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024092">
        <property type="protein sequence ID" value="VDM36428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD07"/>
    <dbReference type="STRING" id="6205.A0A0R3XD07"/>
    <dbReference type="WBParaSite" id="TTAC_0001143401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001143401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001143401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10530768at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001143401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14304" checksum="DA60E3E9071BF431" modified="2016-01-20" version="1">MVSSGRSTPRCSHLSTSRHGIVIDPELTLPQHVQLHAVDPYGVNMTWQLPAKHYNPLTGYTIEWMLEDYWQERLLPPSRLFYTSSRLTPGQSISAAVRAHNLPNTSMIFDYIGERSTHITATTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD23</accession>
    <name>A0A0R3XD23_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HDNR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11433</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024160">
        <property type="protein sequence ID" value="VDM36465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD23"/>
    <dbReference type="WBParaSite" id="TTAC_0001145001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001145001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001145001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001145001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12701" checksum="DC94178DE4ECA9D6" modified="2016-01-20" version="1">MLRQWKMQSHVDSLDHMTVEFPTITEKPQRQPILKSRIRFIDPSEAASMKSRPFDEEALGTAQHRRYNHLFPDSPFFLSDSSHPVPLEGHYSNQSALRHANLTSMTKSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD63</accession>
    <name>A0A0R3XD63_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11473</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024329">
        <property type="protein sequence ID" value="VDM36612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD63"/>
    <dbReference type="STRING" id="6205.A0A0R3XD63"/>
    <dbReference type="WBParaSite" id="TTAC_0001149001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001149001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001149001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001149001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23453" checksum="F54FEC2441B1B80B" modified="2016-01-20" version="1">MIGNLLKMQQAVSTDDLPSASEMAATTLVKRASVDEGDTRPTWIRQLQSSADAWKSLLPDRLRPLERTAENIADPLFRCFDREVSAGTTLLNTVRDDLSNVIKVCSGTTKPTNYHRDLMSDLAKGLIPTSWRRYYTTPSTLTVIQWINDFAARIRQLIEISEAASSADHGNLRGLRVWLGGLFMPEAYITATRQAVAQTHGWALEELFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDF7</accession>
    <name>A0A0R3XDF7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MICOS complex subunit MIC60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11567</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01025090">
        <property type="protein sequence ID" value="VDM37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDF7"/>
    <dbReference type="WBParaSite" id="TTAC_0001158401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001158401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001158401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001158401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5320" checksum="3B15C801F85AC44D" modified="2016-01-20" version="1">MLFRDSLFLASSAAVPTSEAIESPESQKALADVRQVALSWLEQAARWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE24</accession>
    <name>A0A158RE24_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6507</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020306">
        <property type="protein sequence ID" value="VDM30726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RE24"/>
    <dbReference type="WBParaSite" id="TTAC_0000652201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000652201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000652201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287100at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1971"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2401"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2450"/>
            <end position="2475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2496"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1983"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="2458"/>
            <end position="2467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000652201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2629" mass="287452" checksum="4A47F07E424316C5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REG7</accession>
    <name>A0A158REG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7264</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020357">
        <property type="protein sequence ID" value="VDM31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158REG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000727901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000727901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000727901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
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    </dbReference>
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            <begin position="7"/>
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            <dbReference type="PROSITE" id="PS50800"/>
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        <source>
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        </source>
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    <sequence length="1493" mass="162592" checksum="166C2C4C10CCAB72" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REK6</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="8" type="ORF">TTAC_LOCUS7481</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000749601-mRNA-1"/>
        </source>
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    <sequence length="169" mass="18679" checksum="957F5EF392281923" modified="2016-06-08" version="1">MGKIFGGICSLSGVLVIALPVPVIVSNFARIYQQSQQADKKITQQALKVARFKILEQEQHSAFLMGKRLAEAHINALHRTKGDMAKCSSEAATPEASVDYVGTMATCGVLETIQEELDDTRSLLSQLTMSPVQLQHYHLLICLERLIVSLPDDHLFYAVAKLIREISTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REM4</accession>
    <name>A0A158REM4_HYDTA</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="19 20" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ig"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF34">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="541"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="643"/>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="17">
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    <feature type="domain" description="Ig-like" evidence="17">
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    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1040"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1132"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1232"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1326"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1426"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1521"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1613"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1726"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1814"/>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="1958"/>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="17">
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        </location>
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        </location>
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    <feature type="domain" description="Ig-like" evidence="17">
        <location>
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    <feature type="domain" description="Ig-like" evidence="17">
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        </location>
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    <feature type="domain" description="Ig-like" evidence="17">
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    <feature type="domain" description="Ig-like" evidence="17">
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    <feature type="domain" description="Ig-like" evidence="17">
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        </location>
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            <begin position="4176"/>
            <end position="4218"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000758301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="4430" mass="485971" checksum="04FC95F0F52FFEFD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E7M3</accession>
    <name>A0A3P7E7M3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000614">
        <property type="protein sequence ID" value="VDM18670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6272950at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Cyclin"/>
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        <property type="entry name" value="Cyclin-like_dom"/>
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        <property type="entry name" value="Cyclin-like_sf"/>
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        <property type="entry name" value="Cyclin_C-dom"/>
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    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="279"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM18670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="480" mass="54125" checksum="1AB8CCA1C1BC51FD" modified="2019-02-13" version="1">MGLPQSYDDHLIALFFKDDQPTTNADASPAGVDTPQPVRVEQHATTADGSQPLEEAPNLAAAEQFVTPADACPPHEESFHLTMDEQYASPGDPCSSHGETINLFRDEQQASASFTAPPDDEVLETPWEAPHPPLQQDYEAVVNDNESPESAFNSNEIETAVDPLCELLELLIFTQELNLAPSDSVYHPRLGIVTVEECIQTIIEYLRSHIVSTDELNALGFETLLRDNLGDPLIRNDLDCYLQDLEGHLEQDNRYINAYNPNFLCRCGITSEIRNCVVQWMVQLHLWLRIPTQTLHVAVGLMDLYTWLQPILRSDYQLLALAAIRLASHVEFPEISISTRKLCRAVKGAYTPTQIDRMVETIHLYTGNIIIFPTPHTFLESYIIGFSDFSPSRLEWAKKVCKYFFDLGLCQDKLCKYSASLRCAGVLYLIRRMQNVVYTPDYGRVGGAEALRGHSYLPSSSLDDLIWLEPSLFHLSRRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ECB5</accession>
    <name>A0A3P7ECB5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Egal-1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000144">
        <property type="protein sequence ID" value="VDM17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ECB5"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="286"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="520"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="922" mass="99600" checksum="53710421A9FC5291" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EPD9</accession>
    <name>A0A3P7EPD9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004374">
        <property type="protein sequence ID" value="VDM24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EPD9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="197" mass="22443" checksum="CCFABF54A46A9430" modified="2019-02-13" version="1">MDKMMRMEEAARPLPRGATSEVIGYWLQRTVDAFKPASLGHHPMRELGQRLEERIRAWKTYETKLNEAVAHMEEVFSHLQGDEAGHKKMDLEVIEEMLQDAEAAAAALGTPTQLSSVAISRRQFEELKAATEEKAREVALLEEVVRKRVQKVLTSISNWNGRAQDLLTVPEQMPRKLTEKIIAIRELLAETDPVSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ER79</accession>
    <name>A0A3P7ER79_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005434">
        <property type="protein sequence ID" value="VDM25721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ER79"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17588" checksum="BE92110E4904C290" modified="2019-02-13" version="1" fragment="single">MQQQQQQQQQRHQPSPRHNPPPSTTSPSYHGARPRVTEETFEDLLGGFSSSSGQAFGSSRRTQHPKTLAEIRHQKLAQTEDHEALKPMQAPRCIVLEWLEGKEKNVRALLCTLNSVLWEGVRWEQISMADVMTVKQVKQQYRKAARAVHPDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F5M3</accession>
    <name>A0A3P7F5M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020319">
        <property type="protein sequence ID" value="VDM30991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F5M3"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="257" mass="28770" checksum="BB57254CDCF970DC" modified="2019-02-13" version="1">MSFCNGCRRGSGSACRSMFGGFVHWERSRPDSEHVPQSVKQLFPCTHWPELRVLICVISSHHKSVSSREAMLRTVTTSPLYQEARATVVRHRLPRFIDAFGQRDFAALAELTMRESNELHAFCLDSWPPVVYLNSTSFAVMDFVHALNQHMHRYVVAYTFDAGPNAFLLTLADDAPLVLALLAECFGEVEGKRGLSGYGDDSDKKGPHIETHTGHLEVEGIQYSSEVDLSDHRGFLESFPRSGGSIQYVISTEASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F729</accession>
    <name>A0A3P7F729_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003891">
        <property type="protein sequence ID" value="VDM24409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F729"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="69" mass="7805" checksum="9C43CB36C895DB70" modified="2019-02-13" version="1">MTNEFTSILSPVECIIRFQIGLIFRGCSHNCIHMISYLHDEVCNLGRLHHLIGKSHSIFNSFGDSSTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCM7</accession>
    <name>A0A3P7FCM7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006811">
        <property type="protein sequence ID" value="VDM26594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCM7"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="84" mass="9674" checksum="36EAE9F94514279A" modified="2019-02-13" version="1">MHHQHHVSPEKAPTVQGRVSAPLKGHRHLCHHVHQRIRPGRIDSNFLMKTLFHRHRRLTVGRELMCGVASMIPRVVKGLIRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGQ7</accession>
    <name>A0A3P7FGQ7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020355">
        <property type="protein sequence ID" value="VDM31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGQ7"/>
    <dbReference type="OrthoDB" id="10263060at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="241" mass="26990" checksum="22BFD33DD370047C" modified="2019-02-13" version="1">MVFAGCESSGKSTLINNLLEKNEVPRKTLALEFSFCRRSRGSCLPKIVVHLWELGGGMKLSDLLDVIITKDSVKKLCIVIVLDLSKPTQLWAHLIHFISSLESNINIALEEIRSQSNHPDCGLISTFPVPLTIIGSKYDTFLNFKLEYRDLIARSLRFVAHFHGAALFVIIRDYLNCLAFDTSFPVIPPTVEGGPLHILPGQDSFDSIGPPPSDSYLKQTNEGTPFQLWEKAFTRRFPQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FQP2</accession>
    <name>A0A3P7FQP2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS7131</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020348">
        <property type="protein sequence ID" value="VDM31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FQP2"/>
    <dbReference type="OrthoDB" id="6233852at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="14">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="14">
        <location>
            <begin position="249"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="490" mass="56185" checksum="63E6DB371B79A38C" modified="2019-02-13" version="1">MDKSPSKLPCDVLIQGSTSLGVSFKKSDLDAVLITPNFVYREDFFTSFAEVLRNNQNIQDLLVITDTFVPLIKMKFSGTSVDLIMSRYKFSYVPSPLNFDEDPELFYLDVDHYSVHGLSGLHLSQKIRDLVPSFPLFTDLLKVIKIWASRRLISDYVYGFPASVAWAVLCAYICMHTTRFSNGNYPYYGLLSPSINAQVGEDRYETVEGPLSHSYAANQPWKSVTPFNLIQILPRGGNSIDRNSRIRLTTLVKIFFAYFSNWVWPSPVMIAPIVVVPKLRLYSWDPRVDIQNGHEIMPIITPIFPHKNAAYTVRPSSRDIVVKELHRGFHLTKKIVEGSATWEDLFEPYDIRHDYRHFLKLELVADNFQELGRLGGLIDSRLRDLAGYLEEHQYIESVRITKASDLPKHFDIKIGPENLPGISECGREKCFNRAWLLGMKILRAAPLPNGTYPERIVDVTQCLQRFYINLQDRDPNTNFLAKLKSSYVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FUG5</accession>
    <name>A0A3P7FUG5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020368">
        <property type="protein sequence ID" value="VDM31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FUG5"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="174" mass="19514" checksum="8127B3A13E673ABA" modified="2019-02-13" version="1">MAFCPVCNQKVLTHVELEAGKFAHLWAVIFCLLGNDGFRGCFGCCFIPFYLRGFSDVTHTCPRCGTTLGARARRKESYRTKALSSSENVFTTTIEDVIHLNSIMRSGFISFKIGESFFHLSTEEANDKVGEQKAQLKERLVTLESELSDCKATMATLKKELYAKFGDNINLEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6H8</accession>
    <name>A0A3P7G6H8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS10867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022398">
        <property type="protein sequence ID" value="VDM35847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G6H8"/>
    <dbReference type="OrthoDB" id="6225908at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM35847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="148" mass="17077" checksum="9DBE2F167F779460" modified="2019-02-13" version="1">MYTSWRRLHANAMECLDHAVYAHAGPSYPPFPELASVCRNDMKVQLRRGTQLRRANRHLRQITSDHLIYLEESPNFCAVDSLTGKTLTSGRECLLQGHANERCAVLCCGRGHQTYTREVQERCFCQFHWCCSVECQTCSRKEEVHICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G796</accession>
    <name>A0A3P7G796_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS11127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01023025">
        <property type="protein sequence ID" value="VDM36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G796"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010273">
        <property type="term" value="P:detoxification of copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447:SF2">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="411" mass="44883" checksum="7C33A96D54C511CC" modified="2019-02-13" version="1">MVDLRQPTSPGETVESFRSCLLTICSQSLSTSGTILVVSYDRKAVKQTGSGHYALVGGYHPKRDLILLLETAAFKYPSHWAPLTAIYNGMCALDKVTGRPRGYIAGGRLRAVADEWTLYLNSTPLGSLGKTCCCLLQSEGQERGCGWRQDRHDLHSCSGPGNCSPIIRPTSPLQIGPAHRCECPCLVDTLFDHLLAFLIKHRPPDFFFTCHPLWADSSVIVSSTTETATQVIFELVSSAAGRRARLALERLQHRSYEWLTSGSGGPLTYRPISTLGLRLKEAIGTATTSESGVLCRRPACAMPHITDPKIRATALLTAFLLAFPYHTISRRFEAADDAIATDDGGTQGAIVEALRSSNHLLYHLPRLPSQTCFTELTLGTRNELNTLSKILAQLISVRRAPGSRCTENTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GEY1</accession>
    <name>A0A3P7GEY1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001604">
        <property type="protein sequence ID" value="VDM21348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GEY1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM21348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="737" mass="79020" checksum="84146E805A813EF6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GZW4</accession>
    <name>A0A3P7GZW4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS5727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01008775">
        <property type="protein sequence ID" value="VDM27535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GZW4"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM27535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="61" mass="7140" checksum="239FE4AD03BF18FC" modified="2019-02-13" version="1">MCKTTRDYQAAIRLFRQALAVGTDDITVLSAIYSQLGNAYFYEHDFLHALEFHRWDLSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HEV7</accession>
    <name>A0A3P7HEV7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GHMP kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020477">
        <property type="protein sequence ID" value="VDM32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HEV7"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="3">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39684" checksum="A4C058B5F846DB64" modified="2019-02-13" version="1">MRSLIVDRYPEVHRCEFIVRAPGRINLIGACEHIDYSGYAVLPMALRQAVYIAVSSQPTSGRKQIKICSENETLETYEEEMERALNFANCGPPQPLKWYHYVLCGVCGFSEYAKHHFSPIMIEFTKPNLTITPVRIPKGGVFCVADSGARLNKAATPDYNTRVLQCKQAAKILLNHLGKNGGGNEEEVILRSAQRAYGKAQPGQMLGPDSPLARVFVGKLAECAAVRCATHCYAEAQRVLDFKGLCEEEGQGDRDNEDILRKLGELMNASHESCRDLYKCSCPELDRLVDICRWAGSYGSRLTGAGWGGCVISLVPESHSEEFLATVAKTYYNATPEAVSQELFLTQPGRAAGIIDVSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HHT2</accession>
    <name>A0A3P7HHT2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021065">
        <property type="protein sequence ID" value="VDM34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249877at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="451" mass="50831" checksum="C44511780EB12CAF" modified="2019-02-13" version="1">MEEELMVALAADNFTHEGIEAESTKSISLYLPLSLIALWGTGPLNNISLVVQSAQYYEGPENPVLVLYDNHPYDDGIFHNHPIMGVSEIYDFQPNNLGTIVVLFPYRSHEVYDGWEVLVTGSMNCMWAESLHDCFFVLGDGTGFPRNSHYFNGPLDSNTKYAYNFSSSLIPSRDITTTAVFIDASYVCAPDYEDMQSGCARVAPNDRHPDFIVATSPTRSNVGDFLFMLVQQRTKVVVMLDDSRIVNESAVASTLVEDEEEDYVATVPYWPVEEMVNLENFFSTYHVCQIIRHSEQYTHDCCCRMLSVTPVDVMQPWSLTQLQFTGWPRHGVPRVDIFYHFVIKCLKYLNNFPVGSEYGPPTVHSRCERIESDNKPQLIGKSHAFDIXXXXEYGPPTVHSRPNDGRAGTFVCAVVLLNQLRNDSQKVDVFGTVLALSKFRPHIITSQASDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HK20</accession>
    <name>A0A3P7HK20_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021029">
        <property type="protein sequence ID" value="VDM34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HK20"/>
    <dbReference type="OrthoDB" id="9978456at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270">
        <property type="entry name" value="ARMADILLO-TYPE FOLD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="165"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="387" mass="44096" checksum="748A4D8B047B27C7" modified="2019-02-13" version="1">MREMAKNDTSTSRILQCGGIQALESVLSKGTSREKCAAALALLSLALHESTAAMARAQIRSALLDDINMQLSTLQSQMPVSISAEGRRGAVEDMVEDYRSFKSWILERGTLLPEVKAISPVDRRIKTALWMQSVFRRLQWEIHVDDELHGRPEVSKADEKERLHVMLSYSYMQKNIAHKIARTISQSGYRIWLDTQHMPTENDIMDAMAIAVERAFAVCVLYSEAYKRCPNTRLEAQYAQKLDKPMIFCRVEQGYQPGGWLGVLTARQPYIDFAGKFAFEDASGELLQRLANIKMSVRGEKAEIKSKAMTTHQTNEISLWDMEKVNEWFMDQGLPMVYRENISGKDLLFLKKMQSSAPESFFRFLSETWKIASVPVMRSFAEALEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HP01</accession>
    <name>A0A3P7HP01_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024993">
        <property type="protein sequence ID" value="VDM36998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HP01"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="117" mass="12531" checksum="FB60A8E306F4E269" modified="2019-02-13" version="1">MAVIGNDGDFRVWDLKSETVLLHTTLQTPSSSSRRLQGEGDGGDVEMQDEPISDSLSGFLCMAAPQPDVSATANIVDIVAVAGHELIVFVPCRPPPLEEISEGSKKIPLTAVSVRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WID6</accession>
    <name>A0A0R3WID6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS356</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000028">
        <property type="protein sequence ID" value="VDM16299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WID6"/>
    <dbReference type="STRING" id="6205.A0A0R3WID6"/>
    <dbReference type="WBParaSite" id="TTAC_0000035501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000035501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000035501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM16299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000035501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9920" checksum="E58EAB173111A37B" modified="2016-01-20" version="1">MPHQKAVVKTTDMPDDMQQFVVEVAFAAIKTGADNQGIASYVRDAVRREYPGNWHCIVGTNFGSEVTHGKRGLIFFKLAEHGVLLFRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIF3</accession>
    <name>A0A0R3WIF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS377</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000030">
        <property type="protein sequence ID" value="VDM16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIF3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000037601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000037601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000037601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
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        <source>
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    <sequence length="690" mass="77218" checksum="2CC3B3C21FE5D302" modified="2016-06-08" version="2"> </sequence>
</entry>
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        <name evidence="5" type="ORF">TTAC_LOCUS402</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000040101-mRNA-1"/>
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    </evidence>
    <sequence length="359" mass="41700" checksum="FCFC618640963F4F" modified="2016-01-20" version="1">MSRVYIGRLPARCCERDIEKFFRGYGRLRDIVLKTGYGFVEFDDERDADDAVYDLHGRELRGERIVVEHARLPPGARGIRRYGPPTRTDYRVIVENLSSRVSWQDLKDMMRKAGEVTYADAHKQVRNEGYALSFQLNPFSIVEFATYNDMKAAIDKYDGYVLYERRLKVYADKPRHRSRSGSRRSRSRRSSRRSKSRGSRRRDRSRSDSRRRSSSRHSRSDRDRSRRSDHSRSDESRKSGSRSRSRSRRSDRSTSHRSDRRSAGRHSCSASRNGDGSTADKARSRSASRDRSRSGSHERSRSPSRSGSERRSRSGSPVERSRSASKSRSRSRSMSETEEARQEVVEHHSEDEKQESMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIT7</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">TTAC_LOCUS536</name>
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    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
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        </citation>
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    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="925"/>
        </location>
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        </location>
    </feature>
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        </location>
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            <end position="593"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1228" mass="135767" checksum="B0E0FF776D619BDF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIZ6</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">TTAC_LOCUS611</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Hydatigera</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="78"/>
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        </location>
    </feature>
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            <begin position="182"/>
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        </location>
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        <location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="213" mass="23262" checksum="5384AAA58C7B7CEF" modified="2016-01-20" version="1">MLDKRIGFGDLEEKPTLTPTFSARSIGEDTETVAEDGDAEMLETDRLLAQVEARDLIEFGIIPEFVGRFPIITAFHALSERMLTRILTEPRNALLLQYKLLFQIDKCTLTVTEDALRAIARQAMVMKTGARGLRAIMEKVLLQPRYDVPGSDISEVIINEDVILGRTEPTYVYADTQDSCGLGEESVDDGADEVTAEAASSNTAGSTTASISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ80</accession>
    <name>A0A0R3WJ80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein RER1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS715</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000082">
        <property type="protein sequence ID" value="VDM16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ80"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ80"/>
    <dbReference type="WBParaSite" id="TTAC_0000071401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000071401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000071401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000071401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17755" checksum="504668B330F42A07" modified="2016-01-20" version="1">MLFFDKIVPFTFCRWLFFFGTLTFYIVLSGFFRYFLCFIQIQRWEYYLGDPLLPTNSDGEFRPFMRRLSEFKFWKNCTIGTAISITCTFFPFFDLPVFWPILLIYFLTLFYVTMRRQIEHMIRYKYLPFTYGKPRPQGKSVLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJE7</accession>
    <name>A0A0R3WJE7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">TTAC_LOCUS796</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30 31" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000100">
        <property type="protein sequence ID" value="VDM17003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WJE7"/>
    <dbReference type="WBParaSite" id="TTAC_0000079501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000079501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000079501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6272564at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140006">
        <property type="term" value="F:histone H3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0678">Repressor</keyword>
    <keyword evidence="21" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="29">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="27">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="28">
        <location>
            <begin position="992"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="498"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="606"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="920"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="VDM17003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000079501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1796" mass="200715" checksum="1DE331AB97738866" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJF4</accession>
    <name>A0A0R3WJF4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic reticulum oxidoreductin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS803</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000101">
        <property type="protein sequence ID" value="VDM17013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJF4"/>
    <dbReference type="STRING" id="6205.A0A0R3WJF4"/>
    <dbReference type="WBParaSite" id="TTAC_0000080201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000080201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000080201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM17013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000080201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30119" checksum="35C68CE0A327BF2B" modified="2016-01-20" version="1">MQCLIFYHCHCLDESEQGTIYVDLLKNVEKYTGYKGESSARVWRSIYLENLDTTTCKEKRLFYRLISGLQTSISLQLCYNHLLSGFLPKENVWGPSVEEFVRRFHPALVPEALGRLRNLFLAYVVEMRAIAKAAPYLMQQAFYTGDAATDTRTRSMVLDFLSDIDAVFDESQLFHEPGKEILDLKEEFRLRFLNITRIMDCVGCDKCRMWGKLQIQGIGTALKILFNNNLFNKSRCCFAQTQPNAQLKRSEIVSLFNGFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJN9</accession>
    <name>A0A0R3WJN9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTP1_C1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS898</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000124">
        <property type="protein sequence ID" value="VDM17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJN9"/>
    <dbReference type="STRING" id="6205.A0A0R3WJN9"/>
    <dbReference type="WBParaSite" id="TTAC_0000089701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000089701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000089701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057347">
        <property type="entry name" value="TANGO6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25267">
        <property type="entry name" value="TANGO6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 N-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="860"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000089701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127208" checksum="1F871266C1997388" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJT5</accession>
    <name>A0A0R3WJT5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="2 5">3.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS952</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'-&gt;5' exosome-mediated mRNA decay pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="2 5"/>
    <dbReference type="EMBL" id="UYWX01000139">
        <property type="protein sequence ID" value="VDM17222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJT5"/>
    <dbReference type="STRING" id="6205.A0A0R3WJT5"/>
    <dbReference type="WBParaSite" id="TTAC_0000095101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000095101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000095101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM17222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000095101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40654" checksum="F05266962DFDD4E5" modified="2016-01-20" version="1">MSQSDSPNSHISSAESPPCKRRRTSATCSPSPTSSVNAYSPSNTRILRVLRNDIRNKAIYLHARFKDSLDQDAIVILQKSPFPNEVSDLCEARVGVAYAEDNHDLSENVTNFPPWKVNEIVNNDIYHRFTILSGLERANCINMTVIHPAEAHHFSKYTTSKRCMISESPETYKNVVLPLLESNPKDLGWVDNILSGTAEVDRVLLEDKDPNFGFSLVLDYRWDGSKLCELHALALARNSDLKCLRELRACHLPMLRTMLMEGRKQLVAKYNDEENALREEQIIAYFHYPPTFYRLHMHFVHIEGPADGGTQVGKAILAEDVIANLEMRSEYYAERIMPILLHENHTFLTAIQKSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WK15</accession>
    <name>A0A0R3WK15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1042</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000163">
        <property type="protein sequence ID" value="VDM17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WK15"/>
    <dbReference type="STRING" id="6205.A0A0R3WK15"/>
    <dbReference type="WBParaSite" id="TTAC_0000104101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000104101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000104101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249568at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="321"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000104101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62005" checksum="EE839D120673547B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKJ2</accession>
    <name>A0A0R3WKJ2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1235</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000228">
        <property type="protein sequence ID" value="VDM17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKJ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000123401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000123401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000123401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000123401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26998" checksum="97AE2F24CD432D05" modified="2016-01-20" version="1">MVDESLVTTTSLFNAIPDGPEVVLRRFQRLIALEQQQQESDVTSSENGKEWMARLATMKESLHEKEVSFERRYARHQKQLKEVEFQETELRRLRDWRNTLKEQLQSLSDQDADAVSNTNGIDSEIHRLQDRVSLYERTFGLEIRRTKNHDNIQVVMRGCCEDDYDTLSYVILRLSSDSTPMELVKCNPPIADIRKLVEHFNKVGDFRSFLLVLRNRFVRYFQLRKKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKK0</accession>
    <name>A0A0R3WKK0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS1244</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000232">
        <property type="protein sequence ID" value="VDM17686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKK0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKK0"/>
    <dbReference type="WBParaSite" id="TTAC_0000124301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000124301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000124301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM17686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000124301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118643" checksum="FE0DCDAFBB0C9002" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKU8</accession>
    <name>A0A0R3WKU8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 10">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1351</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 10"/>
    <dbReference type="EMBL" id="UYWX01000273">
        <property type="protein sequence ID" value="VDM17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKU8"/>
    <dbReference type="STRING" id="6205.A0A0R3WKU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000136401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000136401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000136401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000010">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000136401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="757" mass="84802" checksum="6DCBE5F1568AC289" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL43</accession>
    <name>A0A0R3WL43_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1464</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in sperm motility, especially in the regulation of flagellar function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000326">
        <property type="protein sequence ID" value="VDM18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL43"/>
    <dbReference type="STRING" id="6205.A0A0R3WL43"/>
    <dbReference type="WBParaSite" id="TTAC_0000147701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000147701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000147701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
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        <property type="entry name" value="KP78A-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="61"/>
            <end position="350"/>
        </location>
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        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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            <begin position="507"/>
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            <begin position="690"/>
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            <begin position="903"/>
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        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038181"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000147701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1133" mass="122913" checksum="C420C12E357DA6D4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL45</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="12" type="ORF">TTAC_LOCUS1466</name>
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    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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            <taxon>Eucestoda</taxon>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM18054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000147901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="829" mass="89647" checksum="B3FFC64E340A9716" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK2</accession>
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        <submittedName>
            <fullName evidence="4">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1627</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000414">
        <property type="protein sequence ID" value="VDM18308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="WBParaSite" id="TTAC_0000164001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164001"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM18308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39838" checksum="0CF51676F3E2B47C" modified="2016-01-20" version="1">MSLRIQSLTHYSDFDGTSESETSELSIVLPFSSRFRSKKQSQPSEGRIRQKKGARAIRRYENGRHLSQPQSLLFLLSVILDLPFSDAYLSTLAMITEASGEDDMEDYWVDRVTGDTGFNIREIWDAFISLSETEQIELLGSLASHSAFSNDFDVDMGNGMAAHPSPRNYNNANRNNSCGRQRRKNKGRSRQRPVVHLEPIFEDPMEMSIDAFDPLSPQDVSSDVAVLPASGVISPKLLQFIRNMVEQQHREQDFVSSRAGVKGGRKKQRRFCVQDLCLIQRVETELRNVFGVVESPVRVWTPSTSLLRSSISSNQTYRGRPWVRGLLLALNGFQRMLVHATANYLGLRSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WML1</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1986</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000662">
        <property type="protein sequence ID" value="VDM18726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WML1"/>
    <dbReference type="STRING" id="6205.A0A0R3WML1"/>
    <dbReference type="WBParaSite" id="TTAC_0000199901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000199901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000199901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="46"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="332"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM18726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000199901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45396" checksum="CDF1E5FACAE555FC" modified="2016-01-20" version="1">MKRPAKTSKQTLAKLRADRENGLFDLKELESLLADYNSPHIDILEQRLQKLGDALLPNFRVYLMEGFNIILYGVGSKLRLLSRLRSEYLNGDNCLVVSGYSSTIGIRKVCICVIFVIFSPQILNVIIDEVMQIEDAPAGIDKRLDLIIDHFSRPTAADAPLFLLINCIDGRNLRTARVQAILARLAAVPHIHIVATMDNINLPILWSQTEVSRFSWIWEECSTLLPYSIEAGFASSHLLQELFGSTGNVGSQLTDRHVFLNPDVDVVALTRLRHVMASLTKNGCDIFRLLVEYQIQAVEEAQADLHEKNATKIIGPKASLKKSRRNEEGEAAPKGMPLEELYWRCRDAFLTNTEVNLRAQLTEFKDHKLIKFLKDSDGTELLCIPLDLASLREIIENKEMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WND2</accession>
    <name>A0A0R3WND2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000901">
        <property type="protein sequence ID" value="VDM19409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WND2"/>
    <dbReference type="WBParaSite" id="TTAC_0000227001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000227001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000227001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6245351at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000227001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52962" checksum="B11347AC9CABB236" modified="2016-01-20" version="1">MGESWKHAGESTEELHSEKSRLCFSTAGNHGESAHVLVKRSFSIISSSTTEVNVAKLPTAQSSGRGRFRNVTRRPYRRTIDLSLSSSGVSDVDELVDQRRKVIDKHRRVNNKCSQDAERTKLQPNNPTTITSCNRDCRQCKRRQTRLGKQLSATSTDLGISTSDIDDDILKSTHNTPPECSTSDSEMDEADEDTLTGGGMKTKLGRRRSTLYSRMEAHHCRMCCDIDAQTSECEFCGLALCDVCCRLHFNTHAADVKSRLERLRNQAVVSTSKEVRHQLMLEIDKAALDLTIACNTALDRALDVYRATASVSTSFIGSLVDRRIKLSNSLKYLLRQIPRILLSDDVYELMYFVKVAKSVHERMEELKIAIGDPRSKEVFKLVLTNPFSSFAPLFEQNSLLLPLDNCDKLQDGCEMSLPTRLTRLKGVAVNSGFFNNAEPRSVSVIAAARGRFIIVIAERGREEEEEEEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNF7</accession>
    <name>A0A0R3WNF7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HintN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2282</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000924">
        <property type="protein sequence ID" value="VDM19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNF7"/>
    <dbReference type="STRING" id="6205.A0A0R3WNF7"/>
    <dbReference type="WBParaSite" id="TTAC_0000229501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000229501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000229501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050387">
        <property type="entry name" value="Hedgehog_Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000320">
        <property type="entry name" value="Hedgehog_signalling_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Zn_M74/Hedgehog-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889">
        <property type="entry name" value="HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889:SF31">
        <property type="entry name" value="PROTEIN HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01085">
        <property type="entry name" value="HH_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="Hedgehog/DD-peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hint" evidence="1">
        <location>
            <begin position="235"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000229501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45695" checksum="1680EC54C361E8D0" modified="2016-01-20" version="1">MIDEPVYKLERFYVAHGCRDRLQKLVSLVHNTWPNNDIGLRILDGWIKPPASLLRQSKVITKRDFMGRHKQTLKMSVPEELVDFETPNKAQHSASRYQSASNGLGIKVSSSDNRVIMQRPLPKQSNNTDTSHHYSIYRNRQWSGQDSTVVGFESPRRQLNQHPVMMEEFHYAGRAVDMILVDTKIDGSPRLRSVYPGKLAQLAYYGALFDWCYFARQGHVHCSVKPDSIITSQWFGCFPGTANAMSATGAPIPLSNLRIGDHVMTLDSRTLKLQPTRVTAFLHRDEHQYSPWIEITYLRRDETTPSKLRVTANHLIYRWQGRRTSVFANQLQPGDKIICNINHPEDLCQVEATRLVNASLTETGVYAPLTRTGDLIIDGVLVSCFAHIRNDWLAQLAVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNI2</accession>
    <name>A0A0R3WNI2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TACC_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2307</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000947">
        <property type="protein sequence ID" value="VDM19586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNI2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNI2"/>
    <dbReference type="WBParaSite" id="TTAC_0000232001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000232001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000232001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000232001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57002" checksum="ED68D5CB9D41E6F3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNK1</accession>
    <name>A0A0R3WNK1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2326</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000965">
        <property type="protein sequence ID" value="VDM19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNK1"/>
    <dbReference type="STRING" id="6205.A0A0R3WNK1"/>
    <dbReference type="WBParaSite" id="TTAC_0000233901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000233901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000233901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000233901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10808" checksum="7C3CAC56AC4967EF" modified="2016-01-20" version="1">MWSNLFVRSTNSPFFKNDVYLIATHGLLTGNAAEKIEQSLLDEVVVTNTVPHEVQKMQCHKIRTVDISSLLAEAIRRIHNGESMSYLFMNVSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ30</accession>
    <name>A0A0R3WQ30_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">glutamate synthase (ferredoxin)</fullName>
            <ecNumber evidence="16">1.4.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS2855</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="16"/>
    <dbReference type="EMBL" id="UYWX01001595">
        <property type="protein sequence ID" value="VDM21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ30"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ30"/>
    <dbReference type="WBParaSite" id="TTAC_0000287001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000287001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000287001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050711">
        <property type="entry name" value="ET-N_metabolism_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938">
        <property type="entry name" value="FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938:SF133">
        <property type="entry name" value="GLUTAMATE SYNTHASE (NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="17">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000287001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51200" checksum="4D6DEDECD4D60122" modified="2016-01-20" version="1">MTAIFILRSSLKVIEQANTMLNRMEHRGACGCDDETGDGAGVMTGIPYELYERFAREAGVTLPTLGEFAVGMFFVNGKDKVEEAMNRFAKYADECEMRVLFWRKADVNNSQIGVVAASAEPVTVQVFVESSRKEEDFKNMKFICKVFFLRKYASHGFEKDEIAYICSLSPNTVVYKGMFTSRQLWDYFEDLQSPDFKTHFAIVHNRFSTNTFPSWSRAHPQRMMAHNGEINTLRGNVNYARARQALMESTRFGERLKQLFPIIENGMSDSGCFDNLLEFLCYCSTRSLPEVVISMIPEAWQADEAMPQQKRYFYKWAASFLEPWDGPALVVFSDGRYIGAILDRNGLRPARYYTTTDGMIYMSSEVGVVDLPDVVGVKAKCRLKPGRLLIVDTQAGELLNDEQLKQDIASHYPIFEWVHKGVSIFLFIHYKFPVNKNLGGSASSIVSSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQN7</accession>
    <name>A0A0R3WQN7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001871">
        <property type="protein sequence ID" value="VDM21870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQN7"/>
    <dbReference type="WBParaSite" id="TTAC_0000307701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000307701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000307701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000307701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9292" checksum="FCB39103FF5552FB" modified="2016-01-20" version="1">MGIRSVDKGKLDWDTRLTTTVVYRWRLLPEGEYAAEDNLTCSIGHVEWLRPQAPLFATAGIAEVEAFSQDDGTVATVSLDLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR12</accession>
    <name>A0A0R3WR12_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1 family domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3186</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002041">
        <property type="protein sequence ID" value="VDM22124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR12"/>
    <dbReference type="STRING" id="6205.A0A0R3WR12"/>
    <dbReference type="WBParaSite" id="TTAC_0000320201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000320201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000320201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000320201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="583" mass="63994" checksum="F11CAA675176D435" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WR90</accession>
    <name>A0A0R3WR90_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3265</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002152">
        <property type="protein sequence ID" value="VDM22273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WR90"/>
    <dbReference type="STRING" id="6205.A0A0R3WR90"/>
    <dbReference type="WBParaSite" id="TTAC_0000328001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000328001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000328001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000328001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7240" checksum="58D1E6A27C429B38" modified="2016-01-20" version="1">MALQDLNARLGKKPEPLEEWPTLFDEEGSGSHSSNPLDVPLHTPSKPPDDMETKSVQQSTDSLPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRN6</accession>
    <name>A0A0R3WRN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3411</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002393">
        <property type="protein sequence ID" value="VDM22578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRN6"/>
    <dbReference type="WBParaSite" id="TTAC_0000342601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000342601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000342601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000342601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12092" checksum="23EA8713F2576996" modified="2016-01-20" version="1">MAEMSLVENLQRRIARAFDFAARGASDAVDRKEQSKLADGENRDRNSPRTTKHFDDPTEQSDKIEPQDYAFQIHMITIDKAPKWNRETQNTKASQRTGQAGRSAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRW5</accession>
    <name>A0A0R3WRW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3490</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002522">
        <property type="protein sequence ID" value="VDM22740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRW5"/>
    <dbReference type="STRING" id="6205.A0A0R3WRW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000350501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000350501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000350501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="74"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000350501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21271" checksum="BD824EF6552D8BF4" modified="2016-01-20" version="1">MWKNVKPGVYIEFTTDDGESLDGEVLCSDENKKFFMFQRPAKSGRHDTYDVFLYRHENVKEMKIVKQNSSFSYPELDLEKVTARSSRNERQEQERIKLFESDVPKEVRELFEHLSKTLPGDAQFSVRWVKPDIHVLDQTIIKAPYSVESVQFKNESAKAKSERDYVRKLVEKFYSERSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRX4</accession>
    <name>A0A0R3WRX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM78A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3499</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002536">
        <property type="protein sequence ID" value="VDM22753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRX4"/>
    <dbReference type="STRING" id="6205.A0A0R3WRX4"/>
    <dbReference type="WBParaSite" id="TTAC_0000351401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000351401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000351401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9971204at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029638">
        <property type="entry name" value="FAM78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31655">
        <property type="entry name" value="PROTEIN FAM78A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31655:SF7">
        <property type="entry name" value="PROTEIN FAM78A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000351401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34328" checksum="2203CECCCA14A287" modified="2016-01-20" version="1">MSRLTVDKIHVKNLRAYYDDNTGTEVEETDAMLYYKTQTFYCKITIELPTCTADKDWSIGLVQACDFMYLANDYGGLGNSLWEFHPLKSGLRKVINDSDGRQYPFYSVNQSLYNIKKGIVRRTTVNLQIKDYFHPSVVWELPYSKGVHLSEINRKQKFFIWLVAIKYGKKTYGKDEIHILKKIRWEYNLHMEVDPHMPLGQKVRKIYDVQDGSIMMCDSSRSQKLPAAATYAPHCNAAQSLIWYPRDPLRHSRILVPPKQIIVPWETWVYDMLGSTARIRRPIDVTEISESVVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS92</accession>
    <name>A0A0R3WS92_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3620</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002750">
        <property type="protein sequence ID" value="VDM22998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS92"/>
    <dbReference type="STRING" id="6205.A0A0R3WS92"/>
    <dbReference type="WBParaSite" id="TTAC_0000363201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000363201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000363201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM22998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000363201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18689" checksum="E8A2B54E25318402" modified="2016-01-20" version="1">MHVTYQQAQPINRATWGGKFEFVLSCISYAVGLGNVWRFPYLCHKNGGGAFLLPYLVMLALVGLPLFFLEFAFGQFASLGPISIWNVSPLFKGIGYAMVAGSWLLSLYYNVIVAQSLLYLFYSFNSVLPWTYCNNAWNDNATCIDFTRNLTQRFTSGIVWFNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WST6</accession>
    <name>A0A0R3WST6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS3811</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01003094">
        <property type="protein sequence ID" value="VDM23448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WST6"/>
    <dbReference type="STRING" id="6205.A0A0R3WST6"/>
    <dbReference type="WBParaSite" id="TTAC_0000382601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000382601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000382601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6079678at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="250"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="348"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM23448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000382601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60608" checksum="F65D4672C9375D10" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTH9</accession>
    <name>A0A0R3WTH9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 45B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS4054</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003572">
        <property type="protein sequence ID" value="VDM24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTH9"/>
    <dbReference type="WBParaSite" id="TTAC_0000406901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000406901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000406901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042127">
        <property type="entry name" value="TMEM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007">
        <property type="entry name" value="EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 45B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000406901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34190" checksum="C4FE40D8D8273FEB" modified="2016-01-20" version="1">MGGEHDEHSSNQSTTLVTHLSHNGLLPSHIYFGSCFFVLGTWWLIAILRSRYRRDKRKEVALAYPGRCDSCSSKLIEGLVKLVVCIVGVIIEQTTVKFLERPANYTYDSIYVSFMLAAVVDIFGGLRIALPEGIDFLAHSVAFANLGILARSHAWGHLHLTVATRMLTSYVAISATLALVLELHRPQSHILQFIRTGAVMLQGVWFWQAGIVLDSPFARRWVENDHGNLMFITIAFAWDMCGVVLFQTFIAVVVAKLMGRRELEAPMHRLRGSKQNGPSGPVNTEVGDGYKPLQSTEPLEIDHSSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTP7</accession>
    <name>A0A0R3WTP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein_heavy domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003716">
        <property type="protein sequence ID" value="VDM24229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTP7"/>
    <dbReference type="STRING" id="6205.A0A0R3WTP7"/>
    <dbReference type="WBParaSite" id="TTAC_0000413701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000413701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000413701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF37">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000413701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13672" checksum="690614A91D14D997" modified="2016-01-20" version="1">MGQGQEVHARQYIEQAMRQGSWVLLQNCHLSLDYINELPTLLAGLRTESESHCRFTTDALSYTDTVDESVIEQHTPQPNMSYTSSIKPVASDQFRLWIITKDHSRFPVNCLQMPVKFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU88</accession>
    <name>A0A0R3WU88_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4313</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004132">
        <property type="protein sequence ID" value="VDM24660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU88"/>
    <dbReference type="WBParaSite" id="TTAC_0000432801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000432801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000432801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000432801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11387" checksum="7F20A6F144C8F05F" modified="2016-01-20" version="1">MYFTTEDENERQLWVQAIYRATGQTHKPVPPPIHSTTPATDAGAASATANAAGTSSKGVKSGVCLNLHKLTTFFLIIRLRLPKWTVSISLMVSEVFVFKWHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVD7</accession>
    <name>A0A0R3WVD7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005152">
        <property type="protein sequence ID" value="VDM25503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVD7"/>
    <dbReference type="STRING" id="6205.A0A0R3WVD7"/>
    <dbReference type="WBParaSite" id="TTAC_0000472701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000472701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000472701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000472701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17364" checksum="8A5CA16D6928E8D6" modified="2016-01-20" version="1">MEAKVPQPVSLPVVYDCREDFLSYFAGKAFSTFEAFSKELQAFEEATGMQYMMKRTCLFNEGTLGREYLIYRYMHYACVRHVRPASKMGQRICSRDAEPMSDTIGLAFQFVGLSLKLLCNFSRMASFLPAERMALTDFLKAIVLSLFSDLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX26</accession>
    <name>A0A0R3WX26_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS5301</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01006944">
        <property type="protein sequence ID" value="VDM26653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX26"/>
    <dbReference type="STRING" id="6205.A0A0R3WX26"/>
    <dbReference type="WBParaSite" id="TTAC_0000531601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000531601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000531601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM26653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000531601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17500" checksum="1BCC0B7A17A96104" modified="2016-01-20" version="1">MPPKIDPTAITTVFLRVTGGEVAATSALAPKLGPLGLPPKKVADDIAKETADMKGLRLTVKLTIQNRQATVSFVPTTSALLIKALKEPVRDRKKVKNIKHNGNITFLDVLEVARVMRPRSLARELAGTVKEVLGTARSIGCSIDGETPQAVIEKINSGEIVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXS4</accession>
    <name>A0A0R3WXS4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5549</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007945">
        <property type="protein sequence ID" value="VDM27209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXS4"/>
    <dbReference type="WBParaSite" id="TTAC_0000556401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000556401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000556401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000556401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22835" checksum="2BAEB463F2C0B6C7" modified="2016-01-20" version="1">MKKPKFEAKYYEHREELDLLIHDPEDVKGKFGGFEVLLRIGSPVLRNEWNSEANLTASERKYKVGTLLPSVPYELTVRGLVLPNVFSELADPLLFKPSKADQCAPQNVKLEAIDPHTVNMKWDLPAKSHGHIVGYTILWNLNNRKQKSIHLSSGQSYIFTNLQPKVSLSASVCAHYKPEVPPNLEYIGSFSKPSTVITPPSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ46</accession>
    <name>A0A0R3WZ46_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010271">
        <property type="protein sequence ID" value="VDM28221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ46"/>
    <dbReference type="WBParaSite" id="TTAC_0000603601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000603601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000603601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000603601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8816" checksum="AC7E6C387BD07FD5" modified="2016-01-20" version="1">MDTGDLNRPAPLSTSSSTSHSSRNRPRQPRSLPNAVLQTAKELKGRANWEVDAEENHERIHFGRMKHVAAMAKRDRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ81</accession>
    <name>A0A0R3WZ81_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6068</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WZ81"/>
    <dbReference type="WBParaSite" id="TTAC_0000608301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000608301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000608301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="722"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1574"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM30214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000608301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1609" mass="175732" checksum="02E6F00BCE43B3B3" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZD4</accession>
    <name>A0A0R3WZD4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6132</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZD4"/>
    <dbReference type="STRING" id="6205.A0A0R3WZD4"/>
    <dbReference type="WBParaSite" id="TTAC_0000614701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000614701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000614701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000177">
        <property type="entry name" value="Transcription initiation factor IIE subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM30292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000614701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="33127" checksum="5962D8ABDA60C135" modified="2016-01-20" version="1">MDPGLLKEREEFLRRAKNIPVVEKLRPQSQTLPQLNATSPQTKKPPVSSTREYLTMDTRSQNQGKFALLSRIVKYMRRRHLERELHPLSVEEILEELQLYDTPRSDIVWLENEALPNNPKIATTPDKKFKFKPRYDIRSRNDLYQLLKRHETRGLGGIYLDDICEAIPDAEKVIQSLGDTIVQVTTPHDKKTVLFFNDKSFDLNVEDEFKQLWRAVSVEGVHEGKIEEYLHRNGIMSMSADKKVFTPAIKQKRRGQRRNIRPVKLRDNEHLRGILKDFSDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZQ6</accession>
    <name>A0A0R3WZQ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZQ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000629401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000629401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000629401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252983at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000629401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="53478" checksum="9E99D70F13A05261" modified="2016-01-20" version="1">MTGTCKKTTLRTRLVYCSGKAHSIQVVCSPRCPRSCDVLEQFCARKGIQLSPDHPSRNVSDDKASNDSKKPNQEGNLKPNFSPATDNVDNRVHQRIGKSSSDEKTSNEFKKTERDSTKRGNFPSRSSKRDTKRHSQPTSPSNSDDKASNDSKWSGRSSNGKRNSISSSGKRDTKKRSYQLSPPNTAEKSSNESRKSLYDDSKRSNTSSMTGRSDTKRGSQQKGHFTSEEGGFNGEKDGKDGNLRSLHTPSSTPRKGSTKKDIQQNAQSTSVKNPRHDENEELDSISPNGRNDRRKKSPTTASSVSEEESSLNSKNRTGTVGTASDMVDKASIQETSSKDKDIGGRSGTKKGRDYHYATQNGSYVRNQPSLGLKNPEVNSQTQPNDSRKLIADEVGNGGTKKGTDQMDQLSVGPESPNVDNGSQSGGPRKATINRADDEGTRYGFDQSIQASSGPNNAKIDDTSKPNNRIRKNPDGAERDGTRNEQMLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZV1</accession>
    <name>A0A0R3WZV1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6338</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZV1"/>
    <dbReference type="STRING" id="6205.A0A0R3WZV1"/>
    <dbReference type="WBParaSite" id="TTAC_0000635301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000635301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000635301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6245048at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="326"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="446"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="679"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM30528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000635301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="755" mass="82706" checksum="D10B82AE3F58513B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0A6</accession>
    <name>A0A0R3X0A6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6531</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01020307">
        <property type="protein sequence ID" value="VDM30753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0A6"/>
    <dbReference type="STRING" id="6205.A0A0R3X0A6"/>
    <dbReference type="WBParaSite" id="TTAC_0000654601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000654601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000654601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000654601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68774" checksum="C3778C8D44B54F8B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0H9</accession>
    <name>A0A0R3X0H9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS6623</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0H9"/>
    <dbReference type="STRING" id="6205.A0A0R3X0H9"/>
    <dbReference type="WBParaSite" id="TTAC_0000663801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000663801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000663801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM30857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000663801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="804" mass="89959" checksum="1EF371E9D0931E67" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0P9</accession>
    <name>A0A0R3X0P9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS6711</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="UYWX01020317">
        <property type="protein sequence ID" value="VDM30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0P9"/>
    <dbReference type="STRING" id="6205.A0A0R3X0P9"/>
    <dbReference type="WBParaSite" id="TTAC_0000672601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000672601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000672601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM30964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000672601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="556" mass="61080" checksum="4228E517CACA61C5" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X189</accession>
    <name>A0A0R3X189_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6934</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020333">
        <property type="protein sequence ID" value="VDM31222.1"/>
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        <property type="gene ID" value="TTAC_0000694901"/>
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    </dbReference>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0R3X1A9</accession>
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        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TTAC_LOCUS6957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="TTAC_0000697201"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000697201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7143" checksum="03C3A61F87B2952A" modified="2016-01-20" version="1">MHLIAGCFATAVSTLGKTTVAMGQRVRSALRPRGAANRGDAQRCRTAHCYFNCPLSPIDEIRPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS6999</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020337">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="473" mass="54949" checksum="25A74BDD2337ACE3" modified="2016-01-20" version="1">MSDYLRLIPQNRMPQGYAYALRVGFSPGTMGSEYVSVVIPPVRLPGRSRLHPWYSFPRDQWIRTTIQSSRLEAICKRGAQYWLDCVFRWLHFLQQQVKMNELQVAANQDFRRMLQKTILQVFAFRLEYVVFYCHLRRVWQERRLDQLILPDPYGLCPRVCSDRSGRIEEDDGVIEVNRGLARPENRLEQCVSSTSLPTILTSSCFPDPHVGLHTTISFSCQCPANTDYKWMCGPKLCSLHRNWRTPGYWQEGDAKQKLRSTMWRFDPPAYYKHLQCSREGTLDVAYVCINDKIQLTYGFVRPQCRQAEYCVCKPRYHGALCDKVTNGNRYRRRTRKCLDPYHGDCQFPEERDDVTRSDTKVTELRLCRPRPCDRYLKLISQSIEKAPIKAMQVIWQSTKAIRVIMIVTCLLLLLVMALAFWTVSLQSRRAGLFAKECHIGPKEGDGKNGNVIEEKHISNFNHSLCGLAVSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1F3</accession>
    <name>A0A0R3X1F3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7013</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1F3"/>
    <dbReference type="STRING" id="6205.A0A0R3X1F3"/>
    <dbReference type="WBParaSite" id="TTAC_0000702801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000702801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000702801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000702801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="492" mass="52631" checksum="9C3F2F9F2CC6BA3C" modified="2016-01-20" version="1">MTLAQIPRNVDTRYLPRVTVLQKGSRGYGFVVQSKRATGGIFVPTDEIPSLHYLGHVEENNVASRANLRPDDFILEVNGINVATLSHQEVVEAIRDSGDMLSLKVVTLPSPEIEGPNQASGILKNDSGCNTLGRRSCRGGGGGGGVGYSSPTCTTTSPRMIKSGSFVNGASQQDQRTFSREPDGFGTIRRSNDSRQRSCSQGGTSDSAYNPQPYLVISPPKPANGNGYPYDMVNSIINESTLRRSAPQSSIGIPTVSSPPPPPPPPPPPPPPACNTQRKKGFSSAPSPSADFNGTSIFKKSCLRRSTHTPDFQDELKPMESKPSMTSPPPLFCNANGTVNPLLASVLAKLDASETEGITSLASEPPKSKPLQAPIENSFEETLKAAIARRRRQMNQSRESSESEDDFHSLRPVSSGFNQPQSPPSSLSQSKANVTMSCGGVTAPERTTLSSRFEVGRAERPIYSRSQPPPPPPPAPPPPPPQMSGGFRRGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1G0</accession>
    <name>A0A0R3X1G0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">WAC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS7021</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020339">
        <property type="protein sequence ID" value="VDM31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X1G0"/>
    <dbReference type="WBParaSite" id="TTAC_0000703601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000703601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000703601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090535">
        <property type="term" value="C:WICH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140801">
        <property type="term" value="F:histone H2AXY142 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047174">
        <property type="entry name" value="BAZ1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="16">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1153"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1271"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1430"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1354"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="734"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1354"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1370"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VDM31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000703601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1532" mass="171577" checksum="6B2396088C510B6D" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1G9</accession>
    <name>A0A0R3X1G9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7032</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020340">
        <property type="protein sequence ID" value="VDM31338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1G9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1G9"/>
    <dbReference type="WBParaSite" id="TTAC_0000704701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000704701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000704701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62930" checksum="6DFCDF75007A3894" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1N0</accession>
    <name>A0A0R3X1N0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7116</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020347">
        <property type="protein sequence ID" value="VDM31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1N0"/>
    <dbReference type="WBParaSite" id="TTAC_0000713101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000713101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000713101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000713101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20421" checksum="96E696F2CADB6D43" modified="2016-01-20" version="1">MRDQLGVCVALENEKKGTDLGLSEGSSSQHPRTPVFRLPVCPFNPTHLCLIDLVLLLLLLLLLLTTLIRPTHPCACFTQWQESVRLVDKLCDDGRVNLEATFLNCSTPRLSPIASPSHMTHGGGSKTLHSGTNVVDTKGRGGVRIVRRQKEGRGKEEEEEEEEEEEAKWVWVDGDHQLMFVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1W9</accession>
    <name>A0A0R3X1W9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin_4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7222</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020354">
        <property type="protein sequence ID" value="VDM31567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1W9"/>
    <dbReference type="STRING" id="6205.A0A0R3X1W9"/>
    <dbReference type="WBParaSite" id="TTAC_0000723701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000723701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000723701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5834362at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000723701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31645" checksum="B40BF9913CAF661C" modified="2016-01-20" version="1">MEDQDLTSNENLDRASPELWPDQSVSEFITTRQPDLSIQTPSKYRTDLDKEDLELIHDFGSLSTQQLMDKIKHLQNLAYQLMCSHNLNGTCYRWMDCGLAKDVKDLLTSFRSFRCMIITKISGLTDNDDSMKDIKHSNADLTEKHIDNMMALNCGQAMRLVVVRGEEKLPVIIPEGGKVHDVFSAVANAIDEKLRKEKEEYKTLVSRLDKRNAVAIARAFSSNPPPGRLNWRRFWRTHCLTSNEVTLANRDIPLNKIPGLGNGVMLRFVRRNRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2I2</accession>
    <name>A0A0R3X2I2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin_alpha2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TTAC_LOCUS7484</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020376">
        <property type="protein sequence ID" value="VDM31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X2I2"/>
    <dbReference type="WBParaSite" id="TTAC_0000749901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000749901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000749901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
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        <property type="term" value="P:cell adhesion mediated by integrin"/>
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        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
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        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
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        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FG-GAP"/>
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    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
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    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
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        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
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        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043073567" evidence="13">
        <location>
            <begin position="30"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="348"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="469"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="796"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="879"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000749901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1354" mass="150390" checksum="581B6EC750A52538" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X363</accession>
    <name>A0A0R3X363_HYDTA</name>
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        <submittedName>
            <fullName evidence="6">KH_dom_type_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7750</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020400">
        <property type="protein sequence ID" value="VDM32199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="6205.A0A0R3X363"/>
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        <property type="protein sequence ID" value="TTAC_0000776501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000776501"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nuclear exosome (RNase complex)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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    </dbReference>
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        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
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        <property type="entry name" value="S1_RRP4"/>
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        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    </dbReference>
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    <feature type="domain" description="RRP4 S1" evidence="3">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000776501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39747" checksum="C7F5C1E502309B16" modified="2016-01-20" version="1">MPISITPTILQEAYAKGGKDGERREEVKEDFRGIVIPGEVIFTSGANLITGHGTYRVDDSSEVAEVTTPEQSAVKDDSTSVSVLPMHASLAGRLKSVNKLVYVEPPNTRYSGNVGDTVVGRIVEVEQKRWKVDVNSYHLANLSLANVKLPTGELRRKSEDDERAMRSFMREGDLIVAEVREVYRDGSLQLHMPGMRTGRLGEGCVLRLPPSLIRRQKIHRHQLVVPCGGGASVSEEPARNTCVGVIFGCNGLVWIGPERGMNLGARLGATISAQKPCSANGAINTEFEERVAVGRVRNVVLALVACGHLVWETAVLAGCEASFFEELEDVEGSVGGNGADGGARITRLLLPEHQRHLVDLVIAKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3P1</accession>
    <name>A0A0R3X3P1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7962</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020426">
        <property type="protein sequence ID" value="VDM32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3P1"/>
    <dbReference type="STRING" id="6205.A0A0R3X3P1"/>
    <dbReference type="WBParaSite" id="TTAC_0000797701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000797701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000797701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10032067at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000797701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10112" checksum="6576C1586EF87905" modified="2016-01-20" version="1">MSSDDYVRQQQQQENNLTAGMIKMEPTMGRGVASCAASTTGGGGTKTLRGKPSSVLHMEEEKYIALRKRNNIAVRKSREKQRAKQNEVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3P5</accession>
    <name>A0A0R3X3P5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2-C2_1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS7966</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020426">
        <property type="protein sequence ID" value="VDM32444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X3P5"/>
    <dbReference type="STRING" id="6205.A0A0R3X3P5"/>
    <dbReference type="WBParaSite" id="TTAC_0000798101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000798101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000798101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPGR-interacting protein 1 first C2" evidence="7">
        <location>
            <begin position="342"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="61"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM32444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000798101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="685" mass="78074" checksum="28ED1D5A20E1B41A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4L9</accession>
    <name>A0A0R3X4L9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein hairless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8349</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020488">
        <property type="protein sequence ID" value="VDM32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4L9"/>
    <dbReference type="WBParaSite" id="TTAC_0000836401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000836401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000836401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260319at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000836401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="607" mass="64224" checksum="A5A71D7AB0E887FF" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X511</accession>
    <name>A0A0R3X511_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAC1E protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS8515</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020521">
        <property type="protein sequence ID" value="VDM33080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X511"/>
    <dbReference type="STRING" id="6205.A0A0R3X511"/>
    <dbReference type="WBParaSite" id="TTAC_0000853001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000853001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000853001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261431at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF0">
        <property type="entry name" value="STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000853001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="489" mass="53903" checksum="D4B9C84AFF212855" modified="2016-01-20" version="1">MRPAAFFPPAGLLLLCLGGGCGLAACWGRRRSRRLLFLSGGACIVSGILTLIGIVLYVGSVSLAFDSISGPLRVETRYVYSFGAAFRLCIGAFVLSEFSGVFVIHLFLAELRHRQNQRNKARVYGYNMINSVSTVLLSPSRIPTATTSVAQISLTENCLDKAKPRDTPFLSTNRRPLVSKSNHIAVSNHITNSTRVKVIPHAKPPSKKIQVLEVPAHSPQSPKPTEIVNSSPFDESVRWPSVKRRRIVDLTTESMTGVLPVGRLRRGNARSAVNIRNEEEIPDFLSCHKSTQSSKQLLYYSCRECEQMAKQQQQHQQQRHQQHQGNTPNSISRRSPNFHQRPTSESSSSTSSDSITPSISVSYSSYSESEEKLSDKLYYDPSPGRLPHSQCLRQSDSAANKRRFVGHLSNKNNPSMNVHQVEGSTASDSDRDGAELLSTAVCRCPDTCSGAETLTSLSEALAHSPSSTINTPLQRPRKRAKPYQQVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5F1</accession>
    <name>A0A0R3X5F1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcium homeostasis endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS8675</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="VDM33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X5F1"/>
    <dbReference type="WBParaSite" id="TTAC_0000869001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000869001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000869001"/>
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    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
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    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
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    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
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    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
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    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
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    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
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    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SURP motif" evidence="14">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="15">
        <location>
            <begin position="214"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="404"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="747"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1434"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="486"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="561"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="801"/>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="832"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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        </location>
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        <location>
            <begin position="863"/>
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1466"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1511"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1541"/>
            <end position="1554"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000869001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="175151" checksum="DBEB8DA3A5E80C52" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5S0</accession>
    <name>A0A0R3X5S0_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">TFIIS central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020595">
        <property type="protein sequence ID" value="VDM33467.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5S0"/>
    <dbReference type="WBParaSite" id="TTAC_0000883001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000883001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000883001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000883001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8229" checksum="83CB8CD7CEE0DC31" modified="2016-01-20" version="1">KKKEEEEEEEEEEEEEEEEEEKKEEEEEEVVEEKEEEEVVGQEEEEEVLGQEEEEEDFDYTGCNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5S3</accession>
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        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8819</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
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    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020596">
        <property type="protein sequence ID" value="VDM33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5S3"/>
    <dbReference type="STRING" id="6205.A0A0R3X5S3"/>
    <dbReference type="WBParaSite" id="TTAC_0000883401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000883401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000883401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="136"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="368"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000883401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="689" mass="76241" checksum="E6491F32EE1E1631" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5U8</accession>
    <name>A0A0R3X5U8_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">Zgc:</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TTAC_LOCUS8847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020606">
        <property type="protein sequence ID" value="VDM33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5U8"/>
    <dbReference type="WBParaSite" id="TTAC_0000886201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000886201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000886201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000886201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9316" checksum="E2A11D88C5FDA530" modified="2016-01-20" version="1">MSSDAKKDEDTKKEGFFKKMFSAPGKGSSTDKPKKHTNKIGGLGKTSKHSGGNADQKNTHDESPDAGHGEKDPNPDQVLRDSTDACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5Z7</accession>
    <name>A0A0R3X5Z7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020623">
        <property type="protein sequence ID" value="VDM33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="WBParaSite" id="TTAC_0000891501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000891501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000891501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000891501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23261" checksum="4BE36FECCB403296" modified="2016-01-20" version="1">MQKFLSIAYSADGQHLLAAGDSKFVCLYSVSERLLVKRFELTVNLSLEGVQEAHDRRRYLATFGAEAAAARADHRDALLLPGVRSGDDHCRRWWRPDVRVASVSFAPTGDAFAVAATEGVFVYTLEKGGLVSGLLGGVSKWLFDTMAVDEETTPSNARLQLAQGNFSSSLDMALRLQMHSLIEEVIEAVPYSLSEYHPSILDFESSIIRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X642</accession>
    <name>A0A0R3X642_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AGC-kinase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8946</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020633">
        <property type="protein sequence ID" value="VDM33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X642"/>
    <dbReference type="STRING" id="6205.A0A0R3X642"/>
    <dbReference type="WBParaSite" id="TTAC_0000896101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000896101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13588" checksum="2B3CDEB6F4A95838" modified="2016-01-20" version="1">MTVFVFIFISHITFHCLLACLVYIFSSVLRLTVLFSTDLDITPPWKPDVNGDMDTKYIPEEFQRENVAVTPPEKSVYSDFLDQPYFQRFSYHGSRQSLSRQSVLSFGDNGSIPEGALPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6U0</accession>
    <name>A0A0R3X6U0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020725">
        <property type="protein sequence ID" value="VDM33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6U0"/>
    <dbReference type="WBParaSite" id="TTAC_0000924301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000924301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000924301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10046764at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000924301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="751" mass="79615" checksum="435D12A185C6AE6E" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X710</accession>
    <name>A0A0R3X710_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9306</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020754">
        <property type="protein sequence ID" value="VDM34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X710"/>
    <dbReference type="WBParaSite" id="TTAC_0000932101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22856" checksum="9E89BC462C573588" modified="2016-01-20" version="1">MQCKVESEEAKGCVNRVPLASTCACRGRVICAVCIETVEARRDGTCGGSGDSEGVGAVGKAERGDAISPTAPRAHNRRIDAALRVDARSTCVQQLDYRRTLPRPADLQQPPRCHIITTPSTPPLRLTSLTYANACDSPITSRIGASLDCPMCHRCHSWLRPRVAPISWLVGAILTSTRIRLAEVSGLRSRIGGRRERLTVIARTRAMRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7D1</accession>
    <name>A0A0R3X7D1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9441</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020819">
        <property type="protein sequence ID" value="VDM34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7D1"/>
    <dbReference type="STRING" id="6205.A0A0R3X7D1"/>
    <dbReference type="WBParaSite" id="TTAC_0000945601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000945601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000945601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000945601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24442" checksum="E19FF5DE84399B49" modified="2016-01-20" version="1">MVFPGTLLLILGEPAPIDVNCTDGIRWIWVVFRQCAVSPQEIVAVTFGLLSTTIWVVFAVPQIVENCRKGIPDQAVSPFLLLCFLVGDTVNLAGCIFVHQLPLQVSHDSTFYGFTSSLVVGYVLGWISASIYISSRIPQILKNWRRGSTDGLSPITFIFAIVGNVAYALQTFLTSVELTFIIRALPWLFGSLGVVLFDLIFCRYHGRGYISLEEDVEVTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X879</accession>
    <name>A0A0R3X879_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino_oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9739</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021014">
        <property type="protein sequence ID" value="VDM34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X879"/>
    <dbReference type="STRING" id="6205.A0A0R3X879"/>
    <dbReference type="WBParaSite" id="TTAC_0000975401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000975401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000975401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254623at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000975401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="222" mass="23753" checksum="469D30846F27173F" modified="2016-01-20" version="1">GRPRLLFAGEGTIDSQGGQQCTHGAFLSGIERAFDVLDYLQQGGRCRLRDVRIVDYLMGRGSRSFPPHSMVRRGMKSVASSASTSTGTASPPSTPRRHYRRRARRYSETASLDGDTTSPSTSATSSSASSNCSADSPRGGSRLHWPSRTSKWALTKAASDSSPACVPPPRKRLCQESRPNSVEFVESSVASINNGGAMASLGAVRQLFNLPPCHLLALEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9A0</accession>
    <name>A0A0R3X9A0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10110</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021319">
        <property type="protein sequence ID" value="VDM35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9A0"/>
    <dbReference type="STRING" id="6205.A0A0R3X9A0"/>
    <dbReference type="WBParaSite" id="TTAC_0001012501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001012501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001012501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="166"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001012501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="611" mass="70015" checksum="5B6FEDE663A34BC2" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9E0</accession>
    <name>A0A0R3X9E0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10150</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021358">
        <property type="protein sequence ID" value="VDM35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9E0"/>
    <dbReference type="WBParaSite" id="TTAC_0001016501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001016501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001016501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001016501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12411" checksum="38F0154F46894F6B" modified="2016-01-20" version="1">MDGEEDGRGILADFGGETTTLVPKVINGGIAGIVGVSCVFPIDLVKTRLQNQQKGSGVNLLLITPEKAIKLVGNDFFRYHLKTEGLQEDIELPSYDSALAASENGDLCFHAVHAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9W1</accession>
    <name>A0A0R3X9W1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10321</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021547">
        <property type="protein sequence ID" value="VDM35301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9W1"/>
    <dbReference type="STRING" id="6205.A0A0R3X9W1"/>
    <dbReference type="WBParaSite" id="TTAC_0001033601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001033601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001033601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001033601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="476" mass="50304" checksum="1C932E7DC9B2BECD" modified="2016-01-20" version="1">MLAMQTNYPSLPTENESTTSTNPPAPAASATVAAVVVGGVGTNAGRYTSSTLTSTPFPGSSAIDASFSRCAPPANETPTSLNEVLHRSLMASSFAANEINEPVIPRAHSNGKTFDLNALREAASREKKLFECDPSERKEGVMGGYDLPFHMPTGHPQWTTQQDNHPIDMPPKLGQAQETSPPTNTKLGSFSPNVGMLPYTNTGSTKELDYFLAANAARALVNHLGGAGGTGNSGGSAATGGSGGSTVPQPSDDRSKSPSMGFRDIVNPHISPPQQPSSMEPLYAHQRSLSDRSSPSRSSFGLPSLGMSGNAPPNMSVPFNSSPLPFSVPPHFRQNNPSYSSHPSHHLLPPNPFGGLDPNFADRMKDYSTPHHLMDPRFPVANSMSRLPRSVSPMDGDGRNAGIIGDSGMSDASPNSSSSGKFVSPHNQAGGTTGNGGNIVLYPWMNPKSCGKIMLIPLNSKVYCVKFVIRIHEPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA34</accession>
    <name>A0A0R3XA34_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS10395</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021648">
        <property type="protein sequence ID" value="VDM35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA34"/>
    <dbReference type="STRING" id="6205.A0A0R3XA34"/>
    <dbReference type="WBParaSite" id="TTAC_0001041101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001041101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001041101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="273"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001041101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60287" checksum="43BB0634D5CEF13A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB15</accession>
    <name>A0A0R3XB15_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10725</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022134">
        <property type="protein sequence ID" value="VDM35705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB15"/>
    <dbReference type="WBParaSite" id="TTAC_0001074201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001074201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001074201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001074201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8150" checksum="349E5AAFCD259EC8" modified="2016-01-20" version="1">MVWATSEKLGCAINRCDNIFPQWPKPIYLLACQYKPPGNFFRKKPYEEGAPCTQCPEFSTCKDKQCSSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB69</accession>
    <name>A0A0R3XB69_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10779</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022231">
        <property type="protein sequence ID" value="VDM35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB69"/>
    <dbReference type="STRING" id="6205.A0A0R3XB69"/>
    <dbReference type="WBParaSite" id="TTAC_0001079601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001079601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001079601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002470">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001079601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37287" checksum="1B3E90C3B338A6C2" modified="2016-01-20" version="1">MNEMQDVVRAINLTKCYPKKAKPAVNQLTFGVRPGECFGLLGVNGAGKTTTFNMLTTTIHPTSGTILIGDCNITEKSGLSSHDLIGYCPQFDALLSNLTGFETLQLFARIHGYPERVISTLANRLIDRMSLSPHANKPVHTYSGGNLRKLSTAVATVGNPQVLLLDEPTSGMDPGAKRCLWEVIKSLQKAGCSVVLTTHSMEECEALCNRLAIMMDGQFQCFGTVPHLKQRFGEGYILEVDLRVDEPNPQRLFPPPTSITLTDAVGKKCNFEAHGEVRLSKIFRQLLDLRSAGKITTFAVRQVSLDSVFVNFVRSYENAKEDGDFDGDLSGGEPDRVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB89</accession>
    <name>A0A0R3XB89_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDB1-and CUL4-associated factor 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022256">
        <property type="protein sequence ID" value="VDM35777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB89"/>
    <dbReference type="STRING" id="6205.A0A0R3XB89"/>
    <dbReference type="WBParaSite" id="TTAC_0001081601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001081601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001081601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9610195at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="2">
        <location>
            <begin position="60"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001081601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68097" checksum="4722F7FCD174EB88" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBE2</accession>
    <name>A0A0R3XBE2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10852</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022367">
        <property type="protein sequence ID" value="VDM35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBE2"/>
    <dbReference type="STRING" id="6205.A0A0R3XBE2"/>
    <dbReference type="WBParaSite" id="TTAC_0001086901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001086901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001086901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001086901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46573" checksum="738D348D07550E65" modified="2016-01-20" version="1">MDLKIQGVSVHFPYKPYGCQLSMLNRVITALNNKQGCLIESPTGTGKTLALLCAALGWLEHQMLEGSKKVVQDDDLDDFMEGNVQKSLPVCTCGAADSRQIDENIRIPHIIYATRTHKQISQVIRELRKTKYSTINRNRRTAARCIRALNLNGPWDLEEYVEAMTKAHTCPYFFAFKLFERVPLCFCPYNYLLDPVFRETVESEISGSVIIIDEAHNIEDAARAATSVTLLEREVLTASEDLKRCFPLLQSTSDVLAGDVKALINLLSAIHQVMMLTRPRLVAAGSFASSAQVWSDTEIKGLLSTVGLGVDRFETVRRSFNRLNNMIQKEAAFNRDSSRLQSDSRFPNSATIRLFAYIFTMLKFLYSDDMYRIRNYRAVLMEVVNFERQPLGEDLDSSNVSINQWVSKARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBW7</accession>
    <name>A0A0R3XBW7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11027</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022765">
        <property type="protein sequence ID" value="VDM36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBW7"/>
    <dbReference type="STRING" id="6205.A0A0R3XBW7"/>
    <dbReference type="WBParaSite" id="TTAC_0001104401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001104401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001104401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5402602at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001104401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24680" checksum="7C1C95D523809F8C" modified="2016-01-20" version="1">MFDAVTYAYSPSLSLSKERPTLDNPSAAGATNITLSQAVDNNMLSVAKQLLESGVSDFAFSSSPSSPSSPSSLLLRLIAICSLHPLIHGYIEMMELLIDNGAYTYLVDNSGNTPLHWAARNGNLAAVAVLCRSAPTTYVENANCRTPLKEARKHGHPEIVQYLAFHDSTEESEQPEGSEFEHTIVDAVVSNAFHFPFNSFIIHVFVTGSSVRSVPLQALHARCAVRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBY5</accession>
    <name>A0A0R3XBY5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11045</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022799">
        <property type="protein sequence ID" value="VDM36025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBY5"/>
    <dbReference type="STRING" id="6205.A0A0R3XBY5"/>
    <dbReference type="WBParaSite" id="TTAC_0001106201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001106201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001106201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001106201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21323" checksum="29F46A40A18C59FB" modified="2016-01-20" version="1">MGSDCDESDTAAEFTASGQDSTPNESPRAGELDERSIEVEACTQALNVEVPEHLPSPEELIQRGQYLVDCPSWLAFLGEDKRLQYSNHFISRNDKIWELISTEIRYVDLLVMIRDVYLKAFPPRREDSLNLNENLFPHLDEVLKSHTLLLCYMLEAHNARTDHITNNLGQCFIKTVNSIMIACYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD10</accession>
    <name>A0A0R3XD10_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS11420</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01024099">
        <property type="protein sequence ID" value="VDM36431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XD10"/>
    <dbReference type="STRING" id="6205.A0A0R3XD10"/>
    <dbReference type="WBParaSite" id="TTAC_0001143701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001143701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001143701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM36431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001143701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19009" checksum="759DA29F44F2C6A7" modified="2016-01-20" version="1">MRDCNLDCLPENYVMKYYFYHGLSWPQLSYIAEESDGEIVGYVLAKMEEDPDDLPYGHITSLAVKRSHRRLGLARTLMNLASRAMVENFQARYVSLHVRKSNRAALTLYTKNLGFQAYDVEPKYYADGEDAYAMKKDLKPFWDKYGPSDVPFKAVKEKSKQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDM4</accession>
    <name>A0A0R3XDM4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01026167">
        <property type="protein sequence ID" value="VDM37576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDM4"/>
    <dbReference type="STRING" id="6205.A0A0R3XDM4"/>
    <dbReference type="WBParaSite" id="TTAC_0001165101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001165101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001165101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6273183at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM37576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001165101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8581" checksum="3984E9B08DA21BE4" modified="2016-01-20" version="1">MSDQVENSNPRAKAETRTARTGLLFPVGRARRILRRGNYAERVGDAAPVYLAAVLEYLTASVLELAGNAVHDYGLMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD82</accession>
    <name>A0A158RD82_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS63</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000004">
        <property type="protein sequence ID" value="VDM15774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RD82"/>
    <dbReference type="WBParaSite" id="TTAC_0000006201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000006201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000006201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873834at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF1">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="472"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1312"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1408"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1474"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1314"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1409"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM15774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000006201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1510" mass="164757" checksum="3BF2DE224DDF875B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDY4</accession>
    <name>A0A158RDY4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6319</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020299">
        <property type="protein sequence ID" value="VDM30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000633401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000633401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000633401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256281at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="461"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000633401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="938" mass="99743" checksum="BDD48805841F1ADF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE92</accession>
    <name>A0A158RE92_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nup54 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS6899</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE92"/>
    <dbReference type="STRING" id="6205.A0A158RE92"/>
    <dbReference type="WBParaSite" id="TTAC_0000691401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000691401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM31181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="571" mass="61726" checksum="FC77097E79FD854A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF65</accession>
    <name>A0A158RF65_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9008</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020653">
        <property type="protein sequence ID" value="VDM33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF65"/>
    <dbReference type="WBParaSite" id="TTAC_0000902301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000902301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000902301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6220226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000902301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="650" mass="74873" checksum="BD3879FDB0945C72" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7ELC7</accession>
    <name>A0A3P7ELC7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003250">
        <property type="protein sequence ID" value="VDM23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7ELC7"/>
    <dbReference type="OrthoDB" id="6274516at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="181" mass="19701" checksum="495543DA00F1ECF0" modified="2019-02-13" version="1">MRVATMSVLGSAMQSTLTDVAMEWDVKVNGKAADILTIPSQLPPLFSGVFMTAFGLIQADDERKEAHVEGTLKLSYKVEGRTHSQETTVRCLPVKEEEEEEEEDAVVNLGLHRLAAKAQLLELVDKHAALQGDEGEKVEGSGESEVRQQIVDISTNTNVISPFTCFVCVDPDKIGEVGCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EMR3</accession>
    <name>A0A3P7EMR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000282">
        <property type="protein sequence ID" value="VDM17884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EMR3"/>
    <dbReference type="OrthoDB" id="190434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018187895" evidence="2">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM17884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="203" mass="23585" checksum="860A634A1143F9AC" modified="2019-02-13" version="1">MLTLLIILCLISLVWCFNLLRLSPRDLCQPVHYSLAAMMLILLYLIYLFECLNCRTRLELARATKVRFTSDLKSSRHSDGAAVLETEAHDRVITSVKQHFINESTTFKFHLTFVKELIFADEVTRRQYEEHKSRFMKLQQSNDDFVEIKEGSLSQPLVNVFACTYAAFLWAPVNCKQGFKIICMSAPKNNSKTDPYHLILLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EX05</accession>
    <name>A0A3P7EX05_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS4911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005653">
        <property type="protein sequence ID" value="VDM25863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EX05"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM25863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="283" mass="30875" checksum="4567162AD280A9A7" modified="2019-02-13" version="1">MLLQAFFPTLQIDLNQVVNRDGDSLLLQAAMHGSDRSLRIILIYGGAVNSADRYGNTALHWAAVTGNMNCVHYLLDYGIDLDTFNCTNVTPLMLALSFGHIEVANHLLYHGASTTPELNNYDESALTFALNTNNNAIVELILAAEVPPEHRIRELYVSLGQAAFSGCMATVQLLLSHGAPVDFSNALIESPLHAAIRGDNEEIVEFLLSKGANINALNPDGYTPLMEATRRRNVNAVYALINAGADIMALNDANGKTAYTLAEEGKYFEISDMLLEALNCRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EXB0</accession>
    <name>A0A3P7EXB0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009778">
        <property type="protein sequence ID" value="VDM27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EXB0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="255" mass="27722" checksum="8A991519AC5EBFC7" modified="2019-02-13" version="1" fragment="single">MLKDPEASPATDATQSNATKTMETTQSNADIQATNAGVSESFRRHLDEMDTSEKERMRMRRKIMQAKMAAAVKNLNLGRNESRVLTSALALGHKIDSKMRARLMKACMAMQQARTEQCNVAAVTACYRIQTSAVISTGLPLFIGPWCSSYVTKGTACPTGEALEKAKTECGSSGYNIGLKDGFGAHFAVAQSGLQQFAENFQIAVGYKKLKSAAAQIRAMHHDTEDAIEQLAYLTLDATRAVFAIVLLFSTLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZP9</accession>
    <name>A0A3P7EZP9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Laminin EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS5395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01007336">
        <property type="protein sequence ID" value="VDM26883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZP9"/>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000135">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM26883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="72" mass="7925" checksum="90C4316B09E45983" modified="2019-02-13" version="1">MPFTMGRACDECLPGYFNLTTGVGCQDCECHPYGSTHRQCDPNGQCFCRSFASGKKCDQCEASHNTFHPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F762</accession>
    <name>A0A3P7F762_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004202">
        <property type="protein sequence ID" value="VDM24724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F762"/>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="227" mass="25112" checksum="18E43EEA2491C50A" modified="2019-02-13" version="1">MVQISHCGGTAADLLRMEDILTSKLGGDLDGVNAFDFLRLFASAAIVLPEENVSPSFGGTEVSGTPPMEAEDPQGQPLLPPNSMPESGSVEITTAAARNPQSRRMYDIWSAMTSRLVVALCSLEIYRFRPATVALAVLHHFRVSEVETLAKLCDVQMNDVHQCSTLVEELYDVFYRDSHPSSRRALAWTLSKRTFFRIGCSSPTTLDTISEDCETDKEDNLQFMFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FBK1</accession>
    <name>A0A3P7FBK1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipid scramblase CLPTM1L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cisplatin resistance-related protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleft lip and palate transmembrane protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS5028</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71495"/>
            <dbReference type="ChEBI" id="CHEBI:190691"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)</text>
            <dbReference type="Rhea" id="RHEA:71491"/>
            <dbReference type="ChEBI" id="CHEBI:57997"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005999">
        <property type="protein sequence ID" value="VDM26099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FBK1"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM26099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="275" mass="32066" checksum="34440A0364898765" modified="2019-02-13" version="1">MLSSQNNSSVSQTTRLTTHWLSHLEVYVLKDAVSFPINAVPRELMPHFHVVQRKSELVYLPLFFIDPQLQPTYYWMELPGVPTERLNFTIEVIPLSIGRFRLRCMLAQAVEQLKVMGIKDKDLEDLQGIFTETNLYLLLTTVVVSAFHLFFDFLAFKNDVQFWRNAENTTGISIRTIVWRCFSTSIIFLYLYEEKSSLLVVIPSGISAIIEFWKLCRMTKVSFSLRGGVSIGQRSREEEETDKLDAYFMRRLMYFMIPLCVSGAIYSLLYMPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FW64</accession>
    <name>A0A3P7FW64_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024670">
        <property type="protein sequence ID" value="VDM36846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FW64"/>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="89" mass="9729" checksum="37A6AD1235CE2B06" modified="2019-02-13" version="1">MKRRGSANVGSRPPSQKKSSSLEEHIAGLEQDRDYWKSQVELLSQMLTCPGISGSRGTINKQGGSRVSSASKVGRGKIQKDERTSRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G5T2</accession>
    <name>A0A3P7G5T2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS10627</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021956">
        <property type="protein sequence ID" value="VDM35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G5T2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="247" mass="28136" checksum="3D2C1090149CA8E2" modified="2019-02-13" version="1">MTLSSFPDAPNVHISQQVGRLWRNLSNDFREVYAKEARRLQSLHSLEFPDYKYQPRRRLRTLDGDEVDCHPSPLCSASNPPSSNINVVNSYFDELLQNGRPKSQPKPSFPSEFGSKERTNFTDGLLDFTVLRYNPNMDTLTSPQSINGERSIMKYQPEDSNVYQPAFNYPAITDSAANRLSWLDARSIEPFGLPTQTQVTFTGSSFLQPENIFPSNEHWYQYHKEGSFGDPLPLPGIETWTFSGSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G6S7</accession>
    <name>A0A3P7G6S7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS1737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000479">
        <property type="protein sequence ID" value="VDM18468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G6S7"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM18468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="179" mass="20005" checksum="8D3225E9E5B5170A" modified="2019-02-13" version="1">MVIGDFHIPDRSVCIHPAFKALLSPGKIHHVWCTGNLTSRAIYDQLKFICADVHVVKGDFDQLPFPETKVLTVGNLKIGLTHGHQIVPWGNRASLSMLRRQLNVDILISGHTHAAEAYQYDGGTFLNPGSATGAFTPLQKDPQATFMLLDIQESTINLYTYRLVGDEHKVERTEFPRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GCZ9</accession>
    <name>A0A3P7GCZ9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NF-X1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS2526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001174">
        <property type="protein sequence ID" value="VDM20352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GCZ9"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM20352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="342" mass="36575" checksum="8171C0138F2F8C27" modified="2019-02-13" version="1">MLGCSHRCLRQCHAGDCLLPDDDGRVVCKQPCSAPRPECGHPCGKPCHEAAGISCAEALGSLKCHVLVSLSCVCGHRREEQPCYRVKALVANLSKKDPNLLLRCSASTGLPFGLPSTDVLPCDSSCTQAMRAAKEAKEEAEAAASSVPKMWVRGGAHGIDASLPPAFAPPEYSDWLKQFASNNLSFAVEVEKVLYNLVDETLSLMKSSGSKPNLNKCISHRFSPMNHTKRRFIIELAEFYGVECVELDPPPHRYVEALAIGGRVHFPGGGSKQHYMSLAGQMEASFVGSVKINATALMPVHAAARPAPLRCAADTTSARLVSFSSIVGGTSDNSDNRTSKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GKH3</accession>
    <name>A0A3P7GKH3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002477">
        <property type="protein sequence ID" value="VDM22692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GKH3"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="133" mass="13240" checksum="F3931F849EE9D930" modified="2019-02-13" version="1">MAATLQQQQQQQQQHPHHTGTVIVTASPNLLNTAAAAAAMTQRQVTLNGASAVPATTTIEVQGAAGTEVKQVVAATLEGNELKPGATAPAGATAGAPTHLTMASTATGQTFLVPFSGQVAIVNGNTVVTSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GST7</accession>
    <name>A0A3P7GST7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004643">
        <property type="protein sequence ID" value="VDM25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GST7"/>
    <dbReference type="OrthoDB" id="1918237at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="333" mass="37069" checksum="0F8B868FAE8556E8" modified="2019-02-13" version="1">MTMTSKAKFEHDELGDIEVLCDLHHIYLKPICKVHLTVQISGLSCIGAQGRCLSTWEVSEKLRQLCPPLLSPPIQMKVTGATVDFVRFVVELNSRADVRRVIKAADSQRIKLSGFPQTLRVRAGDAPIDCPRKHDWEAFFRDAKDMNELVPGERPDTVVISRLPVRWFARSNSTTKFQPDPDVVEEVFKVYGKIRRIDIPMLDPCQNPQLLTKMGLSVEYVRTLLCDFGHAISAEPDTPVSSSSVHGHDGFGKMAPSTIKPLFSDEKSPTSIDSTSPLTFTAFIQYTDYAGFAAAMEALRGKKLIYAPNDKNNTDSPKFFSAEIKVGTPSSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7GZN6</accession>
    <name>A0A3P7GZN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008281">
        <property type="protein sequence ID" value="VDM27342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7GZN6"/>
    <dbReference type="OrthoDB" id="197735at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030465">
        <property type="entry name" value="CEP131"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31540">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 131 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31540:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 131 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="130" mass="14998" checksum="932F1E6271E7BB39" modified="2019-02-13" version="1">MERVLSVDQLSGQSRCLQEQNAVGVEKALQDCEKRLRDEYETKLEKNYRLIDELIAEKKALTEQCDKLVADMRQISEKALAKQKLMEENHKVELKKAEAKAAAAEKIKRERWEAAKTKSIKVSKSIAMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HH25</accession>
    <name>A0A3P7HH25_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020631">
        <property type="protein sequence ID" value="VDM33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HH25"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="296" mass="32014" checksum="CCDAD2DA797D670D" modified="2019-02-13" version="1">MKTSKLARSTRISLASVVYLTAVLEYLSSTAFSCEVVDLAGRVTKGIKRKTISPRSIMLAVRADEELFKVLSGVIFPFSGTTPYIYPSLLPQKPPKQPSTPRAPSTVKKAKVLHKIKLPLGQTLQIVQADIAELSVDAVVNPTNSTFWMGGMVGSRLMAVGGDAFAKVMRDVRSCITNLQKNSAFVTKGTGIKARNVIHVNGPTWNSNRSAYCIRDLGKTISNCLVTAEKAGFTSIALPSVGSGKANFPKDLAAEIIVNTIKTHLNQGKTSLTDARFVLFDQASIDAYTYELNRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHJ4</accession>
    <name>A0A0R3WHJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000001001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000001001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000001001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21201">
        <property type="entry name" value="CH_VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="150"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000001001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41637" checksum="FEF9CEB797782F9A" modified="2016-01-20" version="1">MPTSNSNSVSEEECDLRQCAEWLNRCRIIPDDHPTLMPDGCGLQLVQTLMDGVKLCNLLSTLTNGEVDPRKMKDFSPQTQQSPFLCFKNIRLFVKLCEDEFGIDKNFLIEPGDLYHAKNFGKVIELLSRLSRCSRAQLSGIPEDMHVTAESNYADMEEETNEIVYDTIVHGGKGSTTKYKWPLSKWLSSQELEEIFKYIEELHCIHRELLSNLSLAVSTTLAVVTLGEVFIKIRDRLLIYGGYCGHVQKAQTLVLEITKNDVEKRNKIQECQAQSDNYSKFHLTELLTVPMQRVLKYHLLLEQLCRLTDDDHPEKPELLTALDGMRELAQTINEVKRDLDTISAIDQIQARYAHILTSSNALLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI08</accession>
    <name>A0A0R3WI08_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RPAP3_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS203</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Dynein-attachment factor required for cilia motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DNAAF19/PR46b family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI08"/>
    <dbReference type="STRING" id="6205.A0A0R3WI08"/>
    <dbReference type="WBParaSite" id="TTAC_0000020201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000020201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000020201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447931at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042422">
        <property type="entry name" value="CC103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031733">
        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein attachment factor N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="11">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM16067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000020201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25992" checksum="06ECF79971898D54" modified="2016-01-20" version="1">MEESHLKSIGLNIDALEVDLKRSVREEQRHWHENDAKLRAVQQKVATYEEFRSMVEGCELRPLKFKEMEEVTKCYAGWSPLPISSASSAVTVPQIHSQSPPSDFQITRFNKIDDFIRCWGDLESHRYDRMLASLLMEQSKELLQEVFVSSAGLPILPQVLRCLLTASSEEPQRVISTLQAIGSSRNFELIATFLSDEEKALIGQIFEVLENNTGSPINSNLRKQWLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIM2</accession>
    <name>A0A0R3WIM2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS458</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="6"/>
    <dbReference type="EMBL" id="UYWX01000040">
        <property type="protein sequence ID" value="VDM16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WIM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000045701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000045701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000045701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="2108"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1413"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1627"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2009"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1371"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2015"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="2504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000045701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="2537" mass="275691" checksum="5C9E53BB3E3C3FA5" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIN5</accession>
    <name>A0A0R3WIN5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YEATS domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS472</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000042">
        <property type="protein sequence ID" value="VDM16498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIN5"/>
    <dbReference type="STRING" id="6205.A0A0R3WIN5"/>
    <dbReference type="WBParaSite" id="TTAC_0000047101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000047101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000047101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16909">
        <property type="entry name" value="YEATS_GAS41_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000047101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25953" checksum="49F5442426B6701E" modified="2016-01-20" version="1">MQQDEAERVKTTVVKPIVFGNISRYLGKKREVDGRTHLWTAFLRPLDPREDMSVYIRRVQFKLHDSYPNPIRIFHRPPYEVTETGWGEFDIVIKVTFVDQNVKPLVITHLLKLFHCDHDIMMGQKSLVREIYDEMIFVDPPPTFYRTLVSPPRGDSSRLPPFNHETDFNEAKQQALARIEDLNKKVTDAITAYREQLILKKDIVEEAKILADEIEASSMGSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIY4</accession>
    <name>A0A0R3WIY4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000062">
        <property type="protein sequence ID" value="VDM16718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIY4"/>
    <dbReference type="STRING" id="6205.A0A0R3WIY4"/>
    <dbReference type="WBParaSite" id="TTAC_0000059501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000059501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000059501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM16718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000059501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48859" checksum="FA4C3441FB41B0DB" modified="2016-01-20" version="1">MIHIPHILMLITGTYLEVILKAITRKLFCLGLTRELLVFRRMANGRILAHTAVTTKDILGSSSSESESEDDALQEANKGQSLLTSTDESIPGSPKEDGFIREVDFIGHEQGDHRKTATEEDESDEIRIAADFPPIRADLGKEMYLVKMPNFLSVETRPFDPSFYEGELDEDEILDEEGRTRLKLKVENTIRWRLSKNANNNVTQESNARIVRWSDGSLSLHLGDEIFDVHKMDIQSDFNHLFIREDRGLQGQAIFRSKLSFRPHSTDSFTHRKMTLSLADKTSKSQKVKILPVAGADPESNRSLAVRKEEERLRVALRRESQQRRMQERQLAAASAHRQRRSVPGPSGYESFGDSDADNTVSLSAIKRNAKAGFLSSSQKNRGECSLSSFPYFIACLNSFGTIDRVGFLTVHTQHLLMVGRSVSDSDDASVSDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ42</accession>
    <name>A0A0R3WJ42_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS669</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000076">
        <property type="protein sequence ID" value="VDM16813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ42"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ42"/>
    <dbReference type="WBParaSite" id="TTAC_0000066801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000066801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000066801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF5">
        <property type="entry name" value="POU DOMAIN MOTIF 3, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific" evidence="8">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="277"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000066801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37343" checksum="79604CF1E1ADA49F" modified="2016-01-20" version="1">MDELATLMSDSALDLSVLPVYNNSSADVSQFPPSHVIMLPASAITISGSDNIPFYISPSGGIVYVAGQLILANTTVERVNEGLVFKQAPLAAVPTSCAAVDEQEPSEQIEFDENSEPDVSSDAGQKLLNQKVKKLASKISKDSFATSSNIVVGGYNVSKLALLADRLKRYRTARALSQAKLSRKISETTTGGLKFSQSFLCRFEKLDVTLRAALGAQPYLEQWLDQVESEEQVALGTSQRSSLHSNEAMVDLLDLRERVVSEGDLEPVKCFLPARRNRKSRAVFSEAAVEQLIQHFKRNSRPRGEELSRLADSIGYERESVRIWFSNRRYQLGVTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKA7</accession>
    <name>A0A0R3WKA7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF4206 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1144</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000194">
        <property type="protein sequence ID" value="VDM17534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKA7"/>
    <dbReference type="STRING" id="6205.A0A0R3WKA7"/>
    <dbReference type="WBParaSite" id="TTAC_0000114301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000114301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000114301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62364at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="6">
        <location>
            <begin position="110"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000114301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41605" checksum="772697C63A7ECB57" modified="2016-01-20" version="1">MATFLPESNILTNVESAHWLCVDCPPYNHEESTIEDQDDQSNSNGDSLSESSWEVLGDGINISVSDDHLSLLARAFPGVMALPHATSVYGGKCALCLSRLFPDDATLDFFDGNFYCSNCHQGQEAVIPRDIIECWDFTPKPVSFATKKFLDSISCHPLIDIGLVNPSLFAWVPELPNVRLLRRTLSLLWSLVSRCSKATSRDLVLALKHRGYMLDNIGTIDSVQDFLDIRSGDLEDHIQAVVTRVALTHVSSCSGCRAWVLSCDICKDVSRPIWPYNLTQFRRCGTPGCRRAMHLDCLLRLKEEKRISLRDSFHTANCLTENKSEITDDPNLANESKLIGNSLLRAGQIELLPRCTACNNNLHVFKIDCPSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKS3</accession>
    <name>A0A0R3WKS3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS1324</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000262">
        <property type="protein sequence ID" value="VDM17813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKS3"/>
    <dbReference type="STRING" id="6205.A0A0R3WKS3"/>
    <dbReference type="WBParaSite" id="TTAC_0000133701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000133701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000133701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF183">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="51"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000133701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34068" checksum="42EE0A742F96F56C" modified="2016-01-20" version="1">MDTVSITKSAAGLQKRGENLRALVQRLTEDLAMRELLRQLAETPRLEENSTTNGSSRTNPEKLVGHICGGSLISASWILTAKHCFDSQLDPSLTQDPSRLTVRVGEYNLHKPEEFQVDHEVEKIFIYPSTENSYDNQYGVLDDIALLKLKRPVTFNKNVQPACLPYPGEQFKAGTVCTVAGWGATEEGLSLLSFLGSQKKLSGTKLSPILRHINVPLISLDDCRDIFAPLTLWNPKFQIHTSFICAGNSESMDACQYDSGGPMMCKSGVDGQYIVVGIISFGIKCASGYPGIYTRVTSFLDWIHDTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL10</accession>
    <name>A0A0R3WL10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rad60-SLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000309">
        <property type="protein sequence ID" value="VDM17978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL10"/>
    <dbReference type="STRING" id="6205.A0A0R3WL10"/>
    <dbReference type="WBParaSite" id="TTAC_0000144101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000144101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000144101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM17978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000144101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7648" checksum="30FFC02BE5F59857" modified="2016-01-20" version="1">MGDDNAPKEKNNEPINLTVHGQDGSVIHFKIKRTTPFKKLMNAYCQRLLDLHDNDTIEVFQTQTGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WL32</accession>
    <name>A0A0R3WL32_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1453</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01000321">
        <property type="protein sequence ID" value="VDM18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WL32"/>
    <dbReference type="STRING" id="6205.A0A0R3WL32"/>
    <dbReference type="WBParaSite" id="TTAC_0000146601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000146601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000146601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF462">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="511"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="845"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000146601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="980" mass="110084" checksum="DCB9D194FDA47BDD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLH1</accession>
    <name>A0A0R3WLH1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000396">
        <property type="protein sequence ID" value="VDM18265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLH1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLH1"/>
    <dbReference type="WBParaSite" id="TTAC_0000160901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000160901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000160901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000160901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30626" checksum="3E63F838CF2D8478" modified="2016-01-20" version="1">MRAWCANLRKIDLPESQTYDKSYDPSGWSAQNVQKPCIAEPPPPRTHGCDPSSGRSRSKKRQIREETIQKLCHPQYPFFKLPPIPPEKSYEKHSCFNETLLGHLEYHDHDARKYYRIFQNRFDLDIVGRFAPHNLCKDYPSAITRKYAFNWPECCIMAFTDTHIPIGIIMAHQTDSKRARITMFAVEHRVDENDVCTYKIAVSMKNKKLIWLEIQRLRKNGIRTVVLAPKDEDRKKQLAHMCRETGPLRQLNVQGEFHFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLI3</accession>
    <name>A0A0R3WLI3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1608</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000400">
        <property type="protein sequence ID" value="VDM18279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLI3"/>
    <dbReference type="WBParaSite" id="TTAC_0000162101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000162101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000162101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10461178at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000162101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="904" mass="101533" checksum="59D6040C61583406" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLK5</accession>
    <name>A0A0R3WLK5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS1630</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000416">
        <property type="protein sequence ID" value="VDM18312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLK5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLK5"/>
    <dbReference type="WBParaSite" id="TTAC_0000164301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM18312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="693" mass="78849" checksum="6200CC90BAC273A9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMI5</accession>
    <name>A0A0R3WMI5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neur_chan_LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS1960</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000640">
        <property type="protein sequence ID" value="VDM18700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMI5"/>
    <dbReference type="STRING" id="6205.A0A0R3WMI5"/>
    <dbReference type="WBParaSite" id="TTAC_0000197301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000197301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000197301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043073563" evidence="11">
        <location>
            <begin position="23"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="63"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="283"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM18700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000197301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="647" mass="73884" checksum="105D6D8CCC9DDC00" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN65</accession>
    <name>A0A0R3WN65_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2190</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000836">
        <property type="protein sequence ID" value="VDM19180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN65"/>
    <dbReference type="STRING" id="6205.A0A0R3WN65"/>
    <dbReference type="WBParaSite" id="TTAC_0000220301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000220301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000220301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM19180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000220301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11262" checksum="703D43BA41067BE7" modified="2016-01-20" version="1">MIFYSFFKTLVGKDVVVELKNDLCIHGTLHSVDQYHNFRLSDITVTDPEKHPYMLSVRNCFIRGSIVRYVQLPADECDVYELQNASRKEATLGKQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNB6</accession>
    <name>A0A0R3WNB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2241</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000886">
        <property type="protein sequence ID" value="VDM19348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WNB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000225401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000225401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000225401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="687"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM19348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000225401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111435" checksum="353B4E0E05ABA148" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP77</accession>
    <name>A0A0R3WP77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2552</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001201">
        <property type="protein sequence ID" value="VDM20428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP77"/>
    <dbReference type="STRING" id="6205.A0A0R3WP77"/>
    <dbReference type="WBParaSite" id="TTAC_0000256501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000256501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000256501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000256501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="40315" checksum="3E2D36A9F979F88D" modified="2016-01-20" version="1">MTPWTSWSVCKVDPLSGRCQQTRTRTCFNVTAIEETALPPSGAAFPDSTPTCPQSVLESRFCESSECAIGEALQTTNEKKNGPSSTNIREIMFYVGLVAAFTVTALIIFTVCRLNRRKPSSFSNPLCPRRFSTRQNEYGKSMTILRNSRSSTYDMPPITNGVGSLPRQLKAGEGTPIGLPDYPANNASPRHLVQSQTQRPVSGTEAGNTYNQPYSPIPTMFAPLSPSFPNGRPFQSPKFNYLVKESPSFGSTGNSVPYSPLPGGGGYTNPPPPGQPIPPLPPPHMVPSRSSASSSTGGVQTQSPQQQQPIYLSPSSTPNTGLGGAEGGDDSSSAFYHEIGTAAESIFPLIPPLPVAAGETGSTTWANIGSVGGVVNLPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPC8</accession>
    <name>A0A0R3WPC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS2604</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001274">
        <property type="protein sequence ID" value="VDM20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPC8"/>
    <dbReference type="STRING" id="6205.A0A0R3WPC8"/>
    <dbReference type="WBParaSite" id="TTAC_0000261801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000261801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000261801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000261801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="555" mass="62254" checksum="A070C77C25E41C01" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPH9</accession>
    <name>A0A0R3WPH9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coactosin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS2654</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001335">
        <property type="protein sequence ID" value="VDM20781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPH9"/>
    <dbReference type="STRING" id="6205.A0A0R3WPH9"/>
    <dbReference type="WBParaSite" id="TTAC_0000266901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000266901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000266901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM20781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000266901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15488" checksum="6CE7CCD9E46ED414" modified="2016-01-20" version="1">MTAAIDKATISTAYEEVRNDNEETTWMCVGDQGGTLTVLEKGTTFNEIYALLDSAARLFFFVRLTVGDEMSKRAKFGLITWIGNDCRPIQKGRVASEKSRIKECIQNFAVDLTYSEAADLTQEAVEEAMRRAGGANYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ92</accession>
    <name>A0A0R3WQ92_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS2915</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01001670">
        <property type="protein sequence ID" value="VDM21501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ92"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ92"/>
    <dbReference type="WBParaSite" id="TTAC_0000293201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000293201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000293201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6283679at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048179">
        <property type="term" value="C:activin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048185">
        <property type="term" value="F:activin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017002">
        <property type="term" value="F:activin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM21501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000293201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25836" checksum="585D6C68C6C1C4E6" modified="2016-01-20" version="1">MSAVTRILSEGETDRISGAGEGSPVVEYWLVTDYLAFGSVYDYIHDRELSWGQMLWIAMGMARGLSYLHTELPRTVSQYPKPSIAHRDFKSRNVLLKPDLTPCISDLGLATRLETGRGFGDAHLQVGTARYMAPEVLDGAIQFTRDAFLRIDVYALGLVIWELMTRAHGPSDIPPDENAPPRLPPYMAPFEAEVGPIPTMDKLQHYVAKLKNRPRARPWWEKDQVSECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU1</accession>
    <name>A0A0R3WQU1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3116</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001949">
        <property type="protein sequence ID" value="VDM21988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU1"/>
    <dbReference type="STRING" id="6205.A0A0R3WQU1"/>
    <dbReference type="WBParaSite" id="TTAC_0000313101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546764at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF3">
        <property type="entry name" value="PROTEIN KINTOUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="3">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM21988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37683" checksum="C6A474C740D2445D" modified="2016-01-20" version="1">MEKSLRDLKLTSDELTKLEKAFKDPEFCKLFAEYAEELNDPENKRRFVAGFVHLQTARFGLYEEEIKLAEMERGVDVEFIKPIPFCVLKSRNWPSLRSGLAGANQFHKEALGMVEGQKVFINICSSEKLGMPEIIPGGDGRSPSWSIPHSFSPPVEDLDKENKLCLVKQAKTVWSTSHSGEKAILASVHLLKGLTHKGTLRATVIRRKRADFKQCQERLAEAEKAAFAEARNGPNPKETLAALSKYKRYLDENMGTIEKMAKDEEAALPSKYKKPEVMITHSSEFDMLDYTNDCCHSIRSTRPTAIKVEITLPGIESAACLDLDITEKKLHLQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQU2</accession>
    <name>A0A0R3WQU2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps39_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001950">
        <property type="protein sequence ID" value="VDM21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQU2"/>
    <dbReference type="STRING" id="6205.A0A0R3WQU2"/>
    <dbReference type="WBParaSite" id="TTAC_0000313201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000313201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000313201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6232571at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000313201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41348" checksum="4C00705A9F7A1933" modified="2016-01-20" version="1">LNESELCPCSSGFISVSDAAYRDNVLAIAYGTRVLLANVQNHATSLLICISDAAILKAISGVRFFNNYVYFSSQDGIIGKAAIPTQLNKSYDLTILNKASTLGGKNFHRFFGGLHITHNGVYAVYVESTVAPAFCNITSNLVFMVLLSNLEVVDLIDRLSGPMRRNVDCLYQVTRLLLSTEYYKSSSMECPSVDMDSEVWSQKLLTFSESALFDTKADLSKLELHKIQFQRAVTMLLIEESSRSPDTKQMLQNQLDRLNKILALRQIDQCYRLFLKTEVQRQYQDCILILRIAVLCQQYLRSDAAKDCGVVALCSMLHRATEAVMSVAQKLLVKRFEVTLSDVNTTVLLVCPVCQTDILFTCSTQFLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQV9</accession>
    <name>A0A0R3WQV9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3134</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001967">
        <property type="protein sequence ID" value="VDM22014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQV9"/>
    <dbReference type="STRING" id="6205.A0A0R3WQV9"/>
    <dbReference type="WBParaSite" id="TTAC_0000314901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000314901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000314901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF423">
        <property type="entry name" value="PROTOCADHERIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000314901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21824" checksum="EB1CC5B9C6F9A3EA" modified="2016-01-20" version="1">MNRPPCQCGHKIQTSTAARRPAQLDREVIERITLIVTVTDSLKKPVFTATATVSIEVQDENDNSPVFVNPPANIGFPFHQNDFQSHAFTVRENAPRYTRLSGRLEARDPDAEIVKEKRVSLILLTYLEKSVAQNCAQRRLIWRRYLQKLASRTARSLKCQRQLSVFGPHVTRFPWFDFMEARICNPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRW9</accession>
    <name>A0A0R3WRW9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002527">
        <property type="protein sequence ID" value="VDM22745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRW9"/>
    <dbReference type="WBParaSite" id="TTAC_0000350901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000350901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000350901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000350901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="49" mass="5565" checksum="DC04BCA9A34C240B" modified="2016-01-20" version="1">MYVCSATLILHASQQRGNENVRLRFGILKTEKRELHFTSLLFDGDAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRZ2</accession>
    <name>A0A0R3WRZ2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3517</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002569">
        <property type="protein sequence ID" value="VDM22789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRZ2"/>
    <dbReference type="STRING" id="6205.A0A0R3WRZ2"/>
    <dbReference type="WBParaSite" id="TTAC_0000353201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000353201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000353201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF25">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000353201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25372" checksum="504877280D254383" modified="2016-01-20" version="1">MDATARDDVVLTLTESDDVTYRQIVKRRRLALLCHFIARSSALIFYLFCSWFTTAFIAPVVALLTLFAIDFWLVKNVSGRLLVGLRWWNSIDPQTGASKWVFESADRAAAGDESVSSRERASRRSAARLFWLGLLLFPVIWAILVLVAVFSLKLAWCLVAACGCLSGSVNAYGYLRCRFKGNSIGGNTAGTSLNGFLTAKMAKSVISDLWSNDANQHNQQQQQQPPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSS4</accession>
    <name>A0A0R3WSS4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003076">
        <property type="protein sequence ID" value="VDM23405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSS4"/>
    <dbReference type="WBParaSite" id="TTAC_0000381401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000381401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000381401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000381401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18030" checksum="8A0681CF9EA0D11D" modified="2016-01-20" version="1">MSAVAWRISMGWFALMHSNELDLWLFLLRGVNAVSGINSLQYLLVKLLAFIDHIEASDSMLPENQNLLSRITALMDRLQPQRMERCADGGSENCSSSQARSRDAVKRLQQYVSENVLMPLHSSTPFSTLGALSANVRAYFQNEDVSSRTFGSSTKNLSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WT77</accession>
    <name>A0A0R3WT77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS3953</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003353">
        <property type="protein sequence ID" value="VDM23841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WT77"/>
    <dbReference type="STRING" id="6205.A0A0R3WT77"/>
    <dbReference type="WBParaSite" id="TTAC_0000396701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000396701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000396701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88853at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM23841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000396701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15801" checksum="6492F7F898F5AB10" modified="2016-01-20" version="1">MGKDLKNLHIIHTEPVKLRHFRSPSNDHSKLIAKALHLTHDDEGQGEKPQQDGVNSIKGEGVAATREKDCALTCSLTAVQPVCGSDGNTYLNPCLLKLRRCMSKRPDELYVVHWGYCPARPPGKLCEAQTSDHYKRGDMSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTG8</accession>
    <name>A0A0R3WTG8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4043</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003551">
        <property type="protein sequence ID" value="VDM24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTG8"/>
    <dbReference type="STRING" id="6205.A0A0R3WTG8"/>
    <dbReference type="WBParaSite" id="TTAC_0000405801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000405801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000405801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000405801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7727" checksum="13E79639C3C1EB48" modified="2016-01-20" version="1">MSTAVSTVPDSTTSPFGNMSVGDPPRLLSELEGGITVQEGDPVHLDVRVASDSDVQITWLKDGNPILPGMYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUL7</accession>
    <name>A0A0R3WUL7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004451">
        <property type="protein sequence ID" value="VDM24960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUL7"/>
    <dbReference type="WBParaSite" id="TTAC_0000445701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000445701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000445701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10551092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000445701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="14852" checksum="6D07C7D58CE2FB83" modified="2016-01-20" version="1">MKTPGFQLCIEEEAVTTATSSGTSVGTLKTSDSRQSVASPNLPSEVASGPLTPVLPPPRRAIHSHSLAFRLRHQTAQKEGATKATTVTTGLQERSNPSLTSQSRTAFTGGLTSASKTIPSVSFLLPSCFFFKSSTLNARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUU8</accession>
    <name>A0A0R3WUU8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004657">
        <property type="protein sequence ID" value="VDM25108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUU8"/>
    <dbReference type="STRING" id="6205.A0A0R3WUU8"/>
    <dbReference type="WBParaSite" id="TTAC_0000453801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000453801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000453801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000453801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12720" checksum="042563E47686E16B" modified="2016-01-20" version="1">MVRGGGADSSALFEDEDTRLFYESLQDIRAMIPAILYKESEQSTSKSAQPQKDDPASTDESSNDAMPFPFRMSFLCLCHRKTIETLKAKQKNMVYYLNRSATSFDFEDGDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUZ9</accession>
    <name>A0A0R3WUZ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4574</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004797">
        <property type="protein sequence ID" value="VDM25218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUZ9"/>
    <dbReference type="STRING" id="6205.A0A0R3WUZ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000458901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000458901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000458901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267848at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000458901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="381" mass="41190" checksum="48BCE7F3805DD3AF" modified="2016-01-20" version="1">MTKSSTFHHQKDIMLSKVAPPQDATKFSTLKKPAKVATVLQQPSCSRQTRKALVEPSANQRFSSMTLPTGIVQPQVSALRYPFCRIQSPQMIRQNSVPNSPCCPSGPFPRFVGRTQNPQQTQQHASMALPYPTTTIPTTTLSCIATPMTQRHAKYLAKQTFTSEEVPKTPSSSSSSRDSGIMSQDSSTSSQSFSNDDFNTSHQMNGAGFRTPQCIARRGKHIAKKIVVEAPSVRYRGSGSSTGGTLSRFRVAKSANVGSRILSTSTSTTSSPVTPRASWTSPSAGGESISMKASSRVGRSTSLCSETLEKEKKRRNVQGRQDPASLAITAAKISGRIPRPTNLAGDENPRGENDVVVLSKKVRQIFKVDEKPTRNSSLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WV75</accession>
    <name>A0A0R3WV75_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VGLL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004959">
        <property type="protein sequence ID" value="VDM25364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WV75"/>
    <dbReference type="WBParaSite" id="TTAC_0000466501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000466501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000466501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000466501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8112" checksum="879419451057A16D" modified="2016-01-20" version="1">MEKPDFMERVITSGKFSKPQLHPQPQGHQSNADTHCGRDFDDKVKQLSSSCSSSASLLLHPDGSASLDGAAKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVC9</accession>
    <name>A0A0R3WVC9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4702</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005131">
        <property type="protein sequence ID" value="VDM25485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVC9"/>
    <dbReference type="STRING" id="6205.A0A0R3WVC9"/>
    <dbReference type="WBParaSite" id="TTAC_0000471901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000471901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000471901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM25485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000471901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13055" checksum="6A02D7889C521A1C" modified="2016-01-20" version="1">MKSWLKDRLFDVTRQITRCIVAEPVVAAALIRHYREWRVEPSGAIRELTSQLVQLRFILRQVLLVSPHETAVRDEYIEKAEKQGAKQGETLQRLIDRLEFMTQEHNKLVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVY8</accession>
    <name>A0A0R3WVY8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4914</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005657">
        <property type="protein sequence ID" value="VDM25869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVY8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVY8"/>
    <dbReference type="WBParaSite" id="TTAC_0000492801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000492801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000492801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6286883at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="265"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000492801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39210" checksum="0B1FDD6ADBB0D0BC" modified="2016-01-20" version="1">MIAQRILNGSYHTFGEVERDFVQMGRNAKHFNEPKSKIYQDAVTLLRIIKEKKIVIKKRFKADPDEETIESNAHEITEDYANLPDAVGMTSPVPKVEDDDEVEDYEADEDGEESSSAAISTPAGFAVVKRRRGRPRKHPLDSVSATPASPTPSEGSADRRSTSSTTTTTITTPIAGGNGSGVGGVVSSGNGSGSGNAATVDLSFLMLDESVAPPGSPPHMAPFVDPTVSSEEQLIPTMLSTAAVGSLRWWGEHVLEAICTATNSMGTLLALPFMRLPSRKLYPDYFRRISNPICLAKIRRKIKRNEYHSLADVRGDIDRVFMNAQAYNMEGSDIYKVAVYLQQLTKSRFVELSQIAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWG7</accession>
    <name>A0A0R3WWG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5093</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006228">
        <property type="protein sequence ID" value="VDM26245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWG7"/>
    <dbReference type="STRING" id="6205.A0A0R3WWG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000510701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000510701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000510701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285946at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000510701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18889" checksum="008BAABEDF1FE22C" modified="2016-01-20" version="1">MSDIDELDYTESQQQDSSSLQYSVEPPGTPPSLPNSPDIHPTQDNLERKHRRSVSEQLFSVPNFHAIASKGNILGHHRKRNTFDKNGDGDTDMGSLGERYGGGSPSGYNTGWDYGNHSVPGAYLSDFSPFERSCETSTNHHSSAGRPYGGTHLKQALKRKVKRALNSSRTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWP0</accession>
    <name>A0A0R3WWP0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006460">
        <property type="protein sequence ID" value="VDM26384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWP0"/>
    <dbReference type="WBParaSite" id="TTAC_0000518001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000518001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000518001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000518001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11742" checksum="78597792256AB2CE" modified="2016-01-20" version="1">SFHLLSYFKHSLFFLAGDDRPRVSSVLNHEPGVPSNDVGSLAIVGKPVAKVCPHVQRNSGKVERSYLVQDYLERRLAAAKNRAKSDNRSYGVACALGHSPVCKCLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWW5</accession>
    <name>A0A0R3WWW5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5239</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006720">
        <property type="protein sequence ID" value="VDM26547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWW5"/>
    <dbReference type="WBParaSite" id="TTAC_0000525501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000525501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000525501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10448616at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000525501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18079" checksum="F73916BAE2D05629" modified="2016-01-20" version="1">MPRSTSSQVYLHRRKTPIPQFLHSAELAHNYEKFGAVQCNNHSLSSSRVDLSTQELCEAVTRAEMWTQRSMRGLREHARSVLAATEAEERRLRARLASLQNQMTMAVETQQSEESSESASITDCPAAERPKSDLMAQEQVSRQLALLRVRALKPYVTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXB3</accession>
    <name>A0A0R3WXB3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAF-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5388</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007303">
        <property type="protein sequence ID" value="VDM26864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXB3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXB3"/>
    <dbReference type="WBParaSite" id="TTAC_0000540301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000540301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000540301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000540301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19316" checksum="6FA479DA7510B4B9" modified="2016-01-20" version="1">MSVTLEDTYCYKHCRNCIFANCPSQECHVLKCPLNCGHKMHACKAEEHISNVCPLAEVPCISASFGCPRRMRRQFLGHHLLKCPASIVHCTAEWNRMPRNVPVNRTSDPHIRSNHYCLLSSKVSDKTKGALRSDLTKLYPALPMTSPLYNGYVILFYFEPEKHVYGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXM5</accession>
    <name>A0A0R3WXM5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5499</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007749">
        <property type="protein sequence ID" value="VDM27099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXM5"/>
    <dbReference type="STRING" id="6205.A0A0R3WXM5"/>
    <dbReference type="WBParaSite" id="TTAC_0000551501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000551501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000551501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10622447at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000551501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30671" checksum="2D9348B5F665C38C" modified="2016-01-20" version="1">MSLDSSPSEGDSEDHVSTSSDSSGASTLATDQEDVFGLISNAGLPLNEALEPYSSNGWPLQPPITEPEDWDGDSPYQSIVNVLRHEATLPLRQLLPPGYHPITSSALEMNGSDDTSIRRRQPQRRPNRLALVNGCSPHDETVDAVVDGLVDDDVDREDEVRSETSAEAEPMELDGYPSDSEVSAASSMTTAAHFWNSVTDAAATPLVPSASPGELARRARGLSQWRTQVPSRRALHSRLPAFGPTCRVPFLPTSSLRECMDSVYFCRCSGNHQVGILAFDEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZH5</accession>
    <name>A0A0R3WZH5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HYPK_UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6181</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020295">
        <property type="protein sequence ID" value="VDM30349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZH5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000619601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000619601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000619601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000619601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11464" checksum="E1E9C85A05B2DAE6" modified="2016-01-20" version="1">MPVAETTLEEKSKRPATHAERNAADLEKMTYNFEETEVTAGMTDALKKVTEEKQSATPAPRIKIKSKDVNLIVQEFEISSIAAEKKLKECHGDVREALCALCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0I8</accession>
    <name>A0A0R3X0I8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6633</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020312">
        <property type="protein sequence ID" value="VDM30869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0I8"/>
    <dbReference type="WBParaSite" id="TTAC_0000664801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000664801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000664801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6267516at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM30869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000664801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15153" checksum="7042A81F71EB7DEB" modified="2016-01-20" version="1">MESEYYTADSSSDKISPPEEKDSRIRQAAQEVAVAAVVVPLSKVMVEDTLPPLYDDAGHYDRYAGVPRNVRTRFLHEDESLLRQVAQGLVKNAVRRATYRVRRSRAVICPWLGNTVPTFGLEHVFHSNCRNHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X134</accession>
    <name>A0A0R3X134_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SagB/ThcOx family dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6865</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020327">
        <property type="protein sequence ID" value="VDM31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X134"/>
    <dbReference type="STRING" id="6205.A0A0R3X134"/>
    <dbReference type="WBParaSite" id="TTAC_0000688001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000688001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000688001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6041973at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010793">
        <property type="entry name" value="Ribosomal_mL37/mL65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039982">
        <property type="entry name" value="Ribosomal_mL65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07147">
        <property type="entry name" value="PDCD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000688001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="593" mass="66776" checksum="FCD16F694B501C42" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X141</accession>
    <name>A0A0R3X141_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS6874</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020328">
        <property type="protein sequence ID" value="VDM31153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X141"/>
    <dbReference type="STRING" id="6205.A0A0R3X141"/>
    <dbReference type="WBParaSite" id="TTAC_0000688901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000688901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000688901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF52">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="15">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM31153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000688901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17030" checksum="D4179D9F05FC1363" modified="2016-01-20" version="1">MAEQIERAFQKQKLLGKKGSRYYKSIGLGYKTPKEAIFGTYIDKKCPFTSDVTIRGRILTGTVRKMKMNRTIVIRRDYMKYVRKYKRFEKRHKNMSVHMSPCFRDVQIGDTVTCGECRPLSKTVSYNVIKVSKASGYKSKKGFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X163</accession>
    <name>A0A0R3X163_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS6901</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020330">
        <property type="protein sequence ID" value="VDM31184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X163"/>
    <dbReference type="STRING" id="6205.A0A0R3X163"/>
    <dbReference type="WBParaSite" id="TTAC_0000691601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000691601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000691601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000691601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35049" checksum="ACCC666BD4E3472D" modified="2016-01-20" version="1">MKGFQYRWVVVESTNGVLEYYEREEHKKFQKPRSSVSLVFATVCPSDEDSQTFIVNTSQGENLRFKGELPKLILRRSFQGVAPLSVGLAGLPSPVQRPSLLPVKEARPVMLNSSNSGRYLAPLLSHPLFKLPCDSHTRTRGYGVDASCNSRKRGVNVARLEHKHTIFNKSEYLKSTSRSEATALSAVELDAVLIENLPWMPLLLIRMLLPFASSLSSEVNLNANDAPALVDPYHQLNELFRLLEREGNLLGRDIDDLYNQPTVAFANRSPEVTELYRNLLIIKATSQASIKSLKQCLGGLQRDNSNVSLDVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1E2</accession>
    <name>A0A0R3X1E2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS7001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020338">
        <property type="protein sequence ID" value="VDM31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1E2"/>
    <dbReference type="WBParaSite" id="TTAC_0000701601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000701601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15394" checksum="02D98064416EA220" modified="2016-01-20" version="1">MRIGLDASFTLIPPPPTQVTQACATSDLPFNRRVSWWRGDTEPSLHPQPFSWGRDGTNQQLLTVEENRGRSTQHCLIEGVDRCQRKPLNVSHACLLGHAQIPPFNCVAATAKTHKTAASSSSSSSCSSSYEPLFALAFEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1J4</accession>
    <name>A0A0R3X1J4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS7067</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020342">
        <property type="protein sequence ID" value="VDM31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1J4"/>
    <dbReference type="STRING" id="6205.A0A0R3X1J4"/>
    <dbReference type="WBParaSite" id="TTAC_0000708201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000708201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000708201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000176">
        <property type="entry name" value="pancreas/duodenum homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000708201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44750" checksum="4013770CD50C114A" modified="2016-01-20" version="1">MQQPLPKCREELKDPSRLVAQGPIKTSKQVNFNTQKSNDGVKNRKRLLEDEPLSSKKTFSDSDKLENTSESVDSLNQGSEDSDAASGTGGDDLSLDMVGSSCDPKRTRTAYTRQQILELEKEFHYNKYLTRKRRLEIAHTLNLSERQIKIWFQNRRMKWKKEHCLPGNKQRLSEPPILTIPSQTFPMRNQESMQFCSNRHGFDVSAVNGDPMMTTRFLPFFPKYLSPTPSAVKTTGMTPLSAPPKRFYDEEGGFDTVWFNDRCYQQSSPQPGFNYPTTSTQSTPPPPPPPSSNNPFSNTLAVAPTDFYSGLLTSTWTSKAPSQQQQQIRHTVNPSYDGEYVNSSNNNSSSPFCIAAHKPSNFPSDDELAISGRNAGSEIEIPNMASAGRIEKECRIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1U0</accession>
    <name>A0A0R3X1U0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS7188</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020352">
        <property type="protein sequence ID" value="VDM31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1U0"/>
    <dbReference type="STRING" id="6205.A0A0R3X1U0"/>
    <dbReference type="WBParaSite" id="TTAC_0000720301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000720301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000720301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000720301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11407" checksum="EE84E3B2AAA944A6" modified="2016-01-20" version="1">MHIEDHLHEGVYLAEMGPSYDTKAESRFSKLIGADAVGMSTAHKTIVAKHVGMKVFAISVITDKVVLDEDFEVIYTHEEVLRTAAKCAEMMKSLLIKMLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X229</accession>
    <name>A0A0R3X229_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glypican-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS7303</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020361">
        <property type="protein sequence ID" value="VDM31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X229"/>
    <dbReference type="STRING" id="6205.A0A0R3X229"/>
    <dbReference type="WBParaSite" id="TTAC_0000731801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000731801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000731801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF29">
        <property type="entry name" value="DIVISION ABNORMALLY DELAYED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000731801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41253" checksum="A7A8F2F5167B6196" modified="2016-01-20" version="1">MLIGMAEASEYELRRILSNLLETTAENFRNDTIVLKSFVADTLGSTMEQLHSQLRNDFSYKFQAHEQFFIKFFSTIQSYLSGTVDALPQLVSSFFDELLYRITQILLNSNSTDTYTVCVINSLRSKQPFLRIPSVITNMTMEAFPPIRVAINSMAFARETLLAASITIHLSNECLAEYQRLRFCSLCAGVINANLCESACFRLAEICTPQQLALGAQWEKFIAALQEILNLVDKFPKVHRPLQMHLTDAIMNLKSVYTLHEQEILSNCSSSSSQVGNVTSAGSDDNGHRRGGHWPFGGHRRSRRQQPPAFYQPPVVYQQPLGHLRSHALEARPLPTVALGEQGIAGLQVWARGVKQRVGLSPSVPLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2M3</accession>
    <name>A0A0R3X2M3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7534</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020381">
        <property type="protein sequence ID" value="VDM31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2M3"/>
    <dbReference type="STRING" id="6205.A0A0R3X2M3"/>
    <dbReference type="WBParaSite" id="TTAC_0000754901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000754901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000754901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000754901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="58502" checksum="52C4E8D94B4682D3" modified="2016-01-20" version="1"> </sequence>
</entry>
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        <name evidence="3" type="ORF">TTAC_LOCUS7760</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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    <reference evidence="3 4" key="2">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="3093"/>
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</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="ARBA" id="ARBA00034036"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
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        <source>
            <dbReference type="EMBL" id="VDM32750.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000824901-mRNA-1"/>
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    <sequence length="1325" mass="148305" checksum="D79A7D3349EB45C0" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4F1</accession>
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        <submittedName>
            <fullName evidence="16">Integrin_alpha2 domain-containing protein</fullName>
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        <name evidence="14" type="ORF">TTAC_LOCUS8273</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type I membrane protein</topology>
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        <text evidence="2 11">Belongs to the integrin alpha chain family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="1"/>
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            <begin position="22"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1227"/>
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    </feature>
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        <location>
            <begin position="410"/>
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        </location>
    </feature>
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            <begin position="905"/>
            <end position="1144"/>
        </location>
    </feature>
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        <location>
            <begin position="1300"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1300"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1357"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003762"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM32793.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000828801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1357" mass="152597" checksum="9DDB14209D6EF81A" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4H9</accession>
    <name>A0A0R3X4H9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8303</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020481">
        <property type="protein sequence ID" value="VDM32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4H9"/>
    <dbReference type="WBParaSite" id="TTAC_0000831801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000831801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000831801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000831801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="11906" checksum="E0275D87A9EF5348" modified="2016-06-08" version="2">MDECGLRETGRVGGRAGEAGGGGGGGNVGAGSGGGGDGRGKRKLAVVEQPPVEWYCGPQFAYVVTNLAVSCVWLHRLMCGANATPGDDVVRGTECDHFKIAPPIAALTTPPPSGKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4P8</accession>
    <name>A0A0R3X4P8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein sister of odd and bowel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS8381</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020494">
        <property type="protein sequence ID" value="VDM32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4P8"/>
    <dbReference type="STRING" id="6205.A0A0R3X4P8"/>
    <dbReference type="WBParaSite" id="TTAC_0000839601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000839601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000839601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000839601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36960" checksum="A2A0B648F3CD85D1" modified="2016-01-20" version="1">MVQASTEHSEIGPPTVSPIPLEELETAEGEDVEPLDLSLSSASTTTARLEESVKSSFSSPVCGTEETRIPLTSPEIPFQLNASSSATLLQLYQILTCIRLWRSAAMEQSFKSDVELNSPFLSIASMPSLHLAPTPLPPPVPPPPPPPPPPSISSMQTRGGANVHALIDPEELRIPTFGKPLRRPIRAPITMAKPPLRKRNLHGSSTPTYLCSHCGRGFTKAYNRTIHERTHTDERPFECNVCARRFRRKDHLRDHRFVSIESNVERLHNSFRAAEQVITGSLLCSYTHLLKKPFACTFCNRGFCQARSLENHKKTNHSEQSAMDVVSINEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4W4</accession>
    <name>A0A0R3X4W4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS8458</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020509">
        <property type="protein sequence ID" value="VDM33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4W4"/>
    <dbReference type="WBParaSite" id="TTAC_0000847301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000847301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000847301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000847301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="47" mass="5102" checksum="FC45C4FB59FB86C9" modified="2016-01-20" version="1">MPFGNASKTPILRVVSSPILSVSLNVSPFVRHMRRSAQSLGYAQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5I8</accession>
    <name>A0A0R3X5I8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="12">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8719</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 12">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41733"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01020569">
        <property type="protein sequence ID" value="VDM33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5I8"/>
    <dbReference type="STRING" id="6205.A0A0R3X5I8"/>
    <dbReference type="WBParaSite" id="TTAC_0000873401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000873401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000873401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000149">
        <property type="entry name" value="Glycogen phosphorylase, muscle form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000873401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="978" mass="112228" checksum="B0AE8A4C1F60E519" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5N0</accession>
    <name>A0A0R3X5N0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS8770</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="UYWX01020582">
        <property type="protein sequence ID" value="VDM33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5N0"/>
    <dbReference type="STRING" id="6205.A0A0R3X5N0"/>
    <dbReference type="WBParaSite" id="TTAC_0000878501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000878501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000878501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000878501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58388" checksum="169C8CC2F5FDFB27" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5T8</accession>
    <name>A0A0R3X5T8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8837</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020602">
        <property type="protein sequence ID" value="VDM33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5T8"/>
    <dbReference type="STRING" id="6205.A0A0R3X5T8"/>
    <dbReference type="WBParaSite" id="TTAC_0000885201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000885201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000885201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285502at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000885201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42369" checksum="39A647D5B7FAF2F0" modified="2016-01-20" version="1">MKTSTCAHVTARQSKKLEAYKPKQCCAYSKDPVVNKIVLKLINQYEEYGAWRQKSRKVAILAGIPPSTSLTRGSYYKPRQTFRDPPADVLNLHANFFTEPKDFCPRTLRSSASSRIRELACYNPPRRRQVGEHLEKSDSGEFRGVSLGNAYQSQVPGLSRKGASQNFVPSPSYIPNQKEQQLKAIRHIAVKLEVPADLMLEFLIHPNHNPVEFDTTKKAELNSSVSTNGTKAPNDKNSDTDSQKNEDSLSSPSTPSQDSCRTTITSQSRQFDCSSRKIGDESDVGSESDDATISLASLSPSDCQSSQQRSSKLTSEIDTSSGLSGGLPAIDSEIEETSRSLSSFDIKRTVKSDKKSKDNSGNDEEEEGTDIDESCTIESFDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X655</accession>
    <name>A0A0R3X655_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cas1_AcylT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8961</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020638">
        <property type="protein sequence ID" value="VDM33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X655"/>
    <dbReference type="WBParaSite" id="TTAC_0000897601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000897601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000897601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6253237at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000897601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61962" checksum="BDE42774920042C0" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X661</accession>
    <name>A0A0R3X661_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8967</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020640">
        <property type="protein sequence ID" value="VDM33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X661"/>
    <dbReference type="WBParaSite" id="TTAC_0000898201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000898201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000898201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000898201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19494" checksum="B62D4D852929CDE7" modified="2016-01-20" version="1">MCTSSPSSLRFTLSRLTPQLTTVYALTTPRSNNSDDCRPRHTIRSCVCTHTIGETPLPSLLLQAAIICCEVCPHLASPQFHLLLQLGTGYRLSDISPTSAFLPRQGGWHNSNASWDDESSSSSNNNNNTAGYLQLLRQMKGLFTRRHRNPIPHSRIETPHFHSSQQHSSSKATVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6B1</accession>
    <name>A0A0R3X6B1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9023</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020658">
        <property type="protein sequence ID" value="VDM33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6B1"/>
    <dbReference type="STRING" id="6205.A0A0R3X6B1"/>
    <dbReference type="WBParaSite" id="TTAC_0000903801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000903801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000903801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000340">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="843"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="800"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000903801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115989" checksum="FF22817B2856B62B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6E0</accession>
    <name>A0A0R3X6E0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020667">
        <property type="protein sequence ID" value="VDM33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6E0"/>
    <dbReference type="WBParaSite" id="TTAC_0000906801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000906801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000906801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6250581at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000906801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19293" checksum="7F744D3F9B2A7AD7" modified="2016-01-20" version="1">MDVLTSITSLKEFVLLRGREQSSKNGSTSFYVDDSLIKSWLDHVKKSLENIADVSEKLFYVASSIQNQFESNEKQCGENGLCSPSFLNEVEVGKHSMRNLIEAISSLQCEIQKLPELIETSRKKFQEEITQFYEEQLEKALSTAIETCLSISKQKIDELTSFVVTNLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Q7</accession>
    <name>A0A0R3X6Q7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9187</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020708">
        <property type="protein sequence ID" value="VDM33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Q7"/>
    <dbReference type="STRING" id="6205.A0A0R3X6Q7"/>
    <dbReference type="WBParaSite" id="TTAC_0000920201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000920201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000920201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="241"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000920201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58306" checksum="CF11B93549512251" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6Y1</accession>
    <name>A0A0R3X6Y1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PseudoU_synth_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9272</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020743">
        <property type="protein sequence ID" value="VDM34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6Y1"/>
    <dbReference type="WBParaSite" id="TTAC_0000928701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000928701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000928701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000928701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8310" checksum="9BC01E6A12C5928F" modified="2016-01-20" version="1">MIITKPTELKEQLTVERFITMTKPDGDINTMTLLIKHLPANLKDLCVLAALTNIHHRGSSNHAGSKENEEEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7B9</accession>
    <name>A0A0R3X7B9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9429</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020813">
        <property type="protein sequence ID" value="VDM34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7B9"/>
    <dbReference type="STRING" id="6205.A0A0R3X7B9"/>
    <dbReference type="WBParaSite" id="TTAC_0000944401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000944401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000944401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9983318at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="118"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000944401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55146" checksum="B6A290F7E5E9E23A" modified="2016-01-20" version="1">MNSTENYSRFLACQRNILEYVRKFGLGYFGVLIVFGTIGNIISLLVIRGVGQTYRQRSYQIQKEPSEEQGQELSALQIGLRHNTSVNIAIEPSQSPSSKAKTGGPKPSGTGAFSHARLSISSPSAVPKRQPMRKHPSKSIFTALAIADTVALWVNPIRYWILFAFGFDIRQHDGVTLCRVHTFLTYATRDIAIWVLCLLTFERYLIGCFPHKAKIIWRGRRKVFAWVGIFAVILAKNSILIFILQLIYPDDVGEFAIVGPSYARLNSSRLLLCDTLDLTSRRVFFYLDIVIYSLVPTGLLLVLNIALFKVIQQRTFMRRRCRFSPKSDDVSAAPREESMQNSVIMHSGSLKIKGSVVQANRLLIPVGIFHLITSVPICIFSIVEDSMQLKRSPSAYVRCVANACGYLLVMLGATTYGVNCLIYFLSSRQFRERLYALTYPTRLARDVEPTSCFLDPNTAMGSPHNPKDRNIKDENPVESMQFCNDALRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7I6</accession>
    <name>A0A0R3X7I6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1_PfpI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020850">
        <property type="protein sequence ID" value="VDM34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7I6"/>
    <dbReference type="STRING" id="6205.A0A0R3X7I6"/>
    <dbReference type="WBParaSite" id="TTAC_0000951101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000951101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000951101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008747">
        <property type="entry name" value="PRK11780.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF17">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000951101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20371" checksum="CAD5C8B3A1D5B281" modified="2016-01-20" version="1">MLIHLSKAGVDVCAFAPNIQQDHVTNHSTGSQVPEKRNVMVESARISRGKIAPLSELKSEGFDALFIPGGFGAATTLSNFVSDGASCAVLPDVKRVLTEFVHAKKPIGLCCIAPVLAARCLPGVHVTTGTDTGTAMAIKKMGAVHENREITEVCIDEDLKVVTAPAYMCATATIADVFENIGLLVKKVLSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7L1</accession>
    <name>A0A0R3X7L1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9521</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020864">
        <property type="protein sequence ID" value="VDM34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7L1"/>
    <dbReference type="WBParaSite" id="TTAC_0000953601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000953601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000953601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6240327at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000953601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12170" checksum="E7981757ACA8E762" modified="2016-01-20" version="1">MYVKLSASFIFFYHDQTPSPKPLRKSPQKPCFEGRIKTTFIVDEADPFLSPTEIIEPLHEDDSDRRGSSDSQGRRKQWLRQAISVDGERVPAKLLHQFSLDVSSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7R0</accession>
    <name>A0A0R3X7R0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PBPb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020894">
        <property type="protein sequence ID" value="VDM34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7R0"/>
    <dbReference type="WBParaSite" id="TTAC_0000958501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000958501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000958501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133243" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000958501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13223" checksum="895017FA65AABAC9" modified="2016-01-20" version="1">MALPFCLIMLAVPTLAAGTAGEDREVTMTKNEVSPESPLSQYFHWRHVAPYSYELGWDVDKLASLAANRIDVFMVVAESFDSPNKRTANFSQGAVVMEKVRPSTLYVARLDALKDKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X881</accession>
    <name>A0A0R3X881_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9741</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021015">
        <property type="protein sequence ID" value="VDM34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X881"/>
    <dbReference type="STRING" id="6205.A0A0R3X881"/>
    <dbReference type="WBParaSite" id="TTAC_0000975601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000975601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000975601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000975601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29139" checksum="B7BC83AA721037C9" modified="2016-01-20" version="1">MPLQGKYEVKLGRSFLDPSQNCFMTMRCDFLPASVDREQPGSIRIVNEKEVDVRLPNVSGAEQSSTLLKGNMRPVQKECLLIYNKTTGELTLERISRAAQLKNVRDGPPGKKPSEPVQNSLPSQSTTTSNQSSKAKVRTMSESSSESSVRVPKPKRTSPPDQRPPPSSNLKRSTLSSSSSSSSSSISEAGSLSNPLHKQRHEQLSSLSSLSEPDDKPVPPPPSALQQSQPTSRDPSSLQPSVSMQRALVANYLHLSESESEEDGEDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8I7</accession>
    <name>A0A0R3X8I7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATG16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021106">
        <property type="protein sequence ID" value="VDM34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8I7"/>
    <dbReference type="STRING" id="6205.A0A0R3X8I7"/>
    <dbReference type="WBParaSite" id="TTAC_0000986201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31781" checksum="DA8DE74D83CF8DAC" modified="2016-01-20" version="1">MTAAGTPSWINDILSQLFIRDAKQSRGYRSIVDYYTGVRDRVFRLDAVNARLERENKRLSAKVEAGRIVANLPNPSELESKVLNLQEEVINLHRQIDKLQCEAKEKQNKIEEQTNRIKELNNLLAESNKINRTCMETIEHLKSANSTLLDEQTANALTVERLEYDKRELVEERTQYLAQITFLQKQIEDLKNTESDMRLQLQRELIHRGLLDAACMPLSVEESPSDQKCRTLSSLPDVIAFSITTADDVNCVRISPSGDLFSYGGLDRKVWLCNIKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Z1</accession>
    <name>A0A0R3X8Z1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HOOK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10001</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021230">
        <property type="protein sequence ID" value="VDM34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Z1"/>
    <dbReference type="WBParaSite" id="TTAC_0001001601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001001601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001001601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6254539at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001001601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22184" checksum="EEDC356552E4D6BA" modified="2016-01-20" version="1">MKPVKDLQQECHALNMRLDMMKKMESEYLEEIEELKRTVDNLAHQLEERRCDPHPESTANVTLEANKSTVEIVQQIDLLQAELELSEKKIIDLESQNALLRERIDILELTKESTILNTTVENTTNELIAEIDGLKTQLCSEISEKERMHILFEEKEQDLVAARFQINELQLTVKVRSLALTSVTLLHQLPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X934</accession>
    <name>A0A0R3X934_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIK helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10042</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021264">
        <property type="protein sequence ID" value="VDM35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X934"/>
    <dbReference type="WBParaSite" id="TTAC_0001005901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001005901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001005901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001005901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24912" checksum="C72162D7D26FEF0E" modified="2016-01-20" version="1">MNRISCAEVFISLCSKSEIIVIVCYPQRLCAAGDQINAESANQQESAVSEKVVFLEPAPSNFSLPSIIPACKKSKDGTHVQSHPEVTAISKRPLSEVANSAARVHKEQPVDSDARQLAQGKAKPACWRDLYWHLVGSRGLKTEEEKVRALFTWICSTSLDRQLFPSAVEEDDAHKVKGKGKHQVDSPDVVLPKLVEGRANYVQVSIKYNRQYVCKWMVSSSKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9F7</accession>
    <name>A0A0R3X9F7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10167</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021381">
        <property type="protein sequence ID" value="VDM35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9F7"/>
    <dbReference type="STRING" id="6205.A0A0R3X9F7"/>
    <dbReference type="WBParaSite" id="TTAC_0001018201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001018201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001018201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10539592at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001018201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16334" checksum="DA7943446682F2AB" modified="2016-01-20" version="1">MTSGDSKAFHVVRPTDSLHSEGVVCTSRKYSIKIVLTVICIADEDYSPSSFTAVAADNGDGNPTSLPITSEAGIAQLDDDVTVTTTDSASVGGRTSICHGDDSDQCRRPQMYTSELKTLRMVENAPYELLRLPDDFLFPVVVSANILRYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9Y1</accession>
    <name>A0A0R3X9Y1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10341</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021573">
        <property type="protein sequence ID" value="VDM35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9Y1"/>
    <dbReference type="STRING" id="6205.A0A0R3X9Y1"/>
    <dbReference type="WBParaSite" id="TTAC_0001035801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001035801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001035801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001035801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17943" checksum="5E638C57F14756D0" modified="2016-01-20" version="1">MFSTDYTLAEVDRGIPHHSVIEDNLYDDREACLHCHSEKDIVSNLYDLDDDLRETQIVVDWLEGKVREEIVKVAEKHECLFNEIAVWENTRHLLETLNASELRSRHLVTQLFPDVALVGEDTLAQKDVSDENRYLHYLFLCVRGGDLQRVCFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA10</accession>
    <name>A0A0R3XA10_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021603">
        <property type="protein sequence ID" value="VDM35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA10"/>
    <dbReference type="WBParaSite" id="TTAC_0001038701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001038701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001038701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001038701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13544" checksum="BBC5DA18A8615701" modified="2016-01-20" version="1">MAAGMPIALSLPLERPRSDANSLSKRAHCSDLHLYVLGARLFGSWLNGAFKDAIMTLNVAIPVSRRLIIAQIESINLATTSIAQSISHPVILKCLIFALNNGVEMNVGRPLDGAIQINVTQTVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA11</accession>
    <name>A0A0R3XA11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021604">
        <property type="protein sequence ID" value="VDM35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA11"/>
    <dbReference type="WBParaSite" id="TTAC_0001038801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001038801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001038801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001038801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11870" checksum="2C954750E9EC53D9" modified="2016-01-20" version="1">MSKGSDMLDMDTAPPLAISSLPPKYVGQVTFKLHSSIPEGKLQSSSFVSDIQHGVLGFVWLLFDCSGAAYKGSKQVAFHIDQQKCLPILAVRVASIHRHNCGSLPTVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA29</accession>
    <name>A0A0R3XA29_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10389</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021634">
        <property type="protein sequence ID" value="VDM35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA29"/>
    <dbReference type="STRING" id="6205.A0A0R3XA29"/>
    <dbReference type="WBParaSite" id="TTAC_0001040601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001040601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001040601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001040601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54099" checksum="7192D3539FB5B4F8" modified="2016-01-20" version="1">MPIYYDRKNQLIFTVHHSVATIAFYLILVSLVRSIYAHRVDLLENATFLAEVAQVTSFIDRRRVAIVSLIFSIFFAITRNFMVIPYWLFIYSIYGTPKHMAAREQLPGLDVPMFVSSLILDALNIYWALMVYPIGYKAAYMLYKADWRTDFDRVRDRIRGRFLSARRRAMNTELLASLRRSTSFNLIQRAWEEWSLIPEDFSETEFCTMSVSERSSPLRRYSDSDDSNINDEGPCTFNMLIPSPMKSISSFCLFAELFLVIFFVDCAILSVGICENLKLTTGSLYYPNFQIYRFFTFFLVNTNVILFVIDAAGFFAFDSLLQRRWNFAEKMKFLMITTWLPGFMCLIYYYIKFACSRTEADLFFTGVNGSSSFVAAVTIVSRQLLYDTSSDAKVQTLYRYASLFYLILIALLQGFGAIPSITLLYSFFGLLYGWTYLRFFQNHTDGKRGDFRGSFSFARQVVARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAZ7</accession>
    <name>A0A0R3XAZ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10709</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022097">
        <property type="protein sequence ID" value="VDM35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAZ7"/>
    <dbReference type="WBParaSite" id="TTAC_0001072401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001072401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001072401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001072401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14213" checksum="E58090A3C03765BC" modified="2016-01-20" version="1">MSNRAYVVLFVAPRISQSNAHSHHHRHSEVHVQCAALPRLWEHSAAACAARCARTCIHPHVCTHVRTYDDVVKSLLISAECASGFVPTLQDDSCTPFMEGLMRHRVRHGQGGDANGRWAPGQPPSDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB08</accession>
    <name>A0A0R3XB08_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10718</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022116">
        <property type="protein sequence ID" value="VDM35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB08"/>
    <dbReference type="WBParaSite" id="TTAC_0001073501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001073501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001073501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001073501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8300" checksum="05CACED1FF2564D3" modified="2016-01-20" version="1">MRLYELIKWAPADAPDAVQTAEVKEDLMSEVINYTIENLSKATNYRIYVASKNSLHKASPFTDYLIAATTGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XB80</accession>
    <name>A0A0R3XB80_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022246">
        <property type="protein sequence ID" value="VDM35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XB80"/>
    <dbReference type="WBParaSite" id="TTAC_0001080701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001080701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001080701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256317at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001080701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34250" checksum="9900028B0804D2CB" modified="2016-01-20" version="1">MLMNVNNNATSGISVPQPQRRSLILIPLGPAEEPPVFNLTLNLNGARSSFLMGIDEWVMKRPSNLQLVHRLVNSFKANLEMVPFTCDSLAKSSLVNHAKWLEEIFSMLLPIEDNDSSILHLACVRQQVRSNGRHVRLIILFTYIDEMLSSMLCSHGITKEVLTPCCKAYATLLCLVAALTPPRKLALELIQSTQQPSVPLPQVQLPQNQQVGFGASVAVTPVKMSESMLGLRVYQETFCCWSAATVQFEHIAIFYSSKEKPVALERHALQVRTRRTSDLIHQSFEYMMQQQQQPRPQPQQNTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD97</accession>
    <name>A0A158RD97_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS167</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000010">
        <property type="protein sequence ID" value="VDM16004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RD97"/>
    <dbReference type="WBParaSite" id="TTAC_0000016601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000016601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000016601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="625"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1283"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM16004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000016601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1849" mass="207745" checksum="E1D39436BD645FBE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDT6</accession>
    <name>A0A158RDT6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6053</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDT6"/>
    <dbReference type="STRING" id="6205.A0A158RDT6"/>
    <dbReference type="WBParaSite" id="TTAC_0000606801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000606801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000606801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF250">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="925"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000606801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118979" checksum="7FFCDE048037AC4D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RED8</accession>
    <name>A0A158RED8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7104</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020346">
        <property type="protein sequence ID" value="VDM31425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RED8"/>
    <dbReference type="WBParaSite" id="TTAC_0000711901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000711901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000711901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6276232at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000711901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56193" checksum="DF17D73DA0A0EB0D" modified="2016-06-08" version="1">MNSWVSGDLTNTQIFCLQCLEGLRYNPTFPHLAACLYFLAFCAKSDKRTECILFISYLRVYCAENADDVIDCLQNKCNTKALRFNLPWSLLESFNGTSKSFFELANNENVTALCNGDINGDSEVDGGGDGEYFIAPPAWYHHSCNHFTPENYESLALFCLEMGLRELGVAFAVRAHQESKRRESPDFCVNDGDGTSTTTTSSFLRIPSLSLPLLRHLDLPLPLRQDEEGWLGCFFVIDRKSLPPALFPFHALNPFHQMCIEAKTVLPFFHSIGLPTDDLEAIFPSVSSSQPPQKPQPEESAVRRRARGSILKSPSCSNDCDRLVHSDATGDDGGVCHDSPRVEKRVRFSLSASHPPPDIEAEFGGRSNSQRLQDMARRRGYLYPTDDVISTGNDNDDSDDSGGGAFDRLVGVFWPDGSRNGGHRRLRWRGRRRYHHHNFGRCLLDVSAFLTCLFALLIFSLLFLSLVVCIPLAWFTTSTGDGTVLTGTCIRLLNAFGLHALLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REJ7</accession>
    <name>A0A158REJ7_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7405</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020369">
        <property type="protein sequence ID" value="VDM31780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REJ7"/>
    <dbReference type="STRING" id="6205.A0A158REJ7"/>
    <dbReference type="WBParaSite" id="TTAC_0000742001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000742001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000742001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="52"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000742001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51729" checksum="83DC63D9CA4854CA" modified="2016-06-08" version="1">MQYAVRGPIVTRSLELEKELQSGEKKNFQQVVKCNIGDCHATGQKPITFFRQVIALCSYPPLLDDSKFPEDAKNRARSILAGCAGGSVGSYSISTGVVSIRERISEYIKRRDGIPTNHTNIFLSNGASEAIKAVLLLLSSSQSGSNRVGVMIPTPQYPLYSATLSEYNVYQINYYLDEDNNWDLDIADMERALAESKENCKPRALVVINPGNPTGQVLSRKSMEDIIRFVKRHGLVLLADEVYQFNVYHPEITPWTSFKRVLHDMGPDYADSVELASFMSASKGYMGECGFRGGYCELTNFDPDVQAQLFKYLSARLCPAVLGQVMIGLICDPPRPSEPSYDLYICQRDSVLADLKEKAQLTTGTLNGLEGVTCNAVQGAMYAFPQIRLPSKAVAVAKEKGMEPDFFYCLSLLEEKGICFVPGSGFGQKPGTYHFRTTILPSIPVMRRVMADLEDFHKAFLAKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REM6</accession>
    <name>A0A158REM6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubulin--tyrosine ligase-like protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS7583</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020385">
        <property type="protein sequence ID" value="VDM31988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REM6"/>
    <dbReference type="STRING" id="6205.A0A158REM6"/>
    <dbReference type="WBParaSite" id="TTAC_0000759801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000759801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000759801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF161">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000759801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="713" mass="81167" checksum="A1DDCA1969900ED4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RET3</accession>
    <name>A0A158RET3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">PBPe domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS8013</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020431">
        <property type="protein sequence ID" value="VDM32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RET3"/>
    <dbReference type="STRING" id="6205.A0A158RET3"/>
    <dbReference type="WBParaSite" id="TTAC_0000802801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000802801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000802801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="264"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000802801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="45999" checksum="4CD00B31351739E0" modified="2016-06-08" version="1">MQAPIEDANDLAKQTKIKYGTRSGGSSAAFFAKSNQSVYQRMWQYMSSQKGVMINNATEAIARVKRGGYAYILESTMNEYFTQRNCDLIQIGDNLDSKGYGIGFPQGSKYRDAFTEVILQLQASQRLEQIRHHWWRYYNITTPCSEKVTKNKDTSSLGVEQIGGCFVMILIGLGASVLISLQEFLYKVYHRVTITKRPFSEEVAREFRFSMARSSTRDFGAESALRLPPPPLPSQCLLPSKECRMAALAYAPCLPAVVRTSPPASATGTAGSVQPGMRRSRSSDSRRPSALEVARMHRRASCRRSSSRYALKNSPQPSQATSSEGPINSANANPAFISDSTRILHPVNGVSAPVEINTHRLMAVSGQSNDLRRYPPPPPPIPQIGFVVRGNGDTYPPPLAGPTGRSYGDIRVKKFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RF20</accession>
    <name>A0A158RF20_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8632</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020549">
        <property type="protein sequence ID" value="VDM33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RF20"/>
    <dbReference type="STRING" id="6205.A0A158RF20"/>
    <dbReference type="WBParaSite" id="TTAC_0000864701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000864701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000864701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17400at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF15">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000864701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="417" mass="49706" checksum="AD237C53C5ECF3ED" modified="2016-06-08" version="1">MALSYFSPCKALFFVRSPTKLASRGLQLAAQCDFEHIKPPPFDFLSTGYPQWLMFDKTKHRFTENTKFVCVEGNIACGKGHVAKKIAEYFGMIHRPDPTDDTIFTLKNYNPPIDVRMHNTMLPKWAQYFTTEMFWTEEDLKEKGKPMYLQYQYYLNRYWNYLIGLCTLFHTGKGIVTDRSHFSDMAFAEALLNCGYISEYAHDWFGYLHANTAINLWKPHLIVYIKASIDQIHDEIKKRGIAWQINAKNLNDDFFCEYRKALEMYLEKMSRYSEIFVVDRSNTDIYNDDDLLIVMEKLTDIDYEGRRLIRDDYKFLEWRTGLVNERSATDNRAKFSSAMMKFTTQFKKFHMPFDMTDGVYSFDAKELQYLVYKRDPRLKYLPGYDPSKDSILRILFDPWLEKRNFRKDWPTFFLTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E626</accession>
    <name>A0A3P7E626_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetratricopeptide repeat protein 21B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000288">
        <property type="protein sequence ID" value="VDM17901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E626"/>
    <dbReference type="OrthoDB" id="10259630at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000219">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="8">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="7">
        <location>
            <begin position="287"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="6">
        <location>
            <begin position="543"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM17901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="83940" checksum="BECE965B062C2195" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E6H0</accession>
    <name>A0A3P7E6H0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000385">
        <property type="protein sequence ID" value="VDM18240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E6H0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM18240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="221" mass="23738" checksum="EB5EBEFCF34D2ECF" modified="2019-02-13" version="1">MVAILIPDNHAYLNLPTTVSGAAASATAQSKSRRLGHGMSSNSESTSNLLLACEEEEVEGYGCPSQDAESPSSNSSFVAFTSNAIDRRRRLRDCRHHRQPSASKIPRIPQAVPPVNTTAQTFFQAHTKLANPLRRIISGGFRQRSNSLRPQSATSSSNHHFFGDVQTQETEAADLANFRVSRKISEGVAGSGGGGVTEPDTFFLPQSSNLTFFGGGQSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7E7W9</accession>
    <name>A0A3P7E7W9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysophospholipid acyltransferase 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS2040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000705">
        <property type="protein sequence ID" value="VDM18780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7E7W9"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF16">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="457" mass="52549" checksum="0C13CB8AB17ECB3B" modified="2019-02-13" version="1">MWGFSYLVFFHTAQFYGFSKPSPLTKMFHLFMTLRVVGVAFELHDTWTTVNALKSNKRNSHSPHGMSDLELKYKGIMTTPYDIVSYVFCYIGMLTGPYYTYRTYNDMLNGWPPKAPGLSFGPLWRRLQEAPFFGVAYLISSQFVSFDDLRDPEFQNGSLVNILVYLSVLFFVYRTRLYFAWIMGECVCMSVGLGAYPAISRPAVGEGPTDLVALNRWVSQFNHKEKSEFQYGSEQHYFPADDIVSNVNSDDPVVIESHSHFYNYATVQAVSVWKCEFSPTVRESFGAWNQTLYYWMDRYMYRRCFGPRFIRSVATLVVNSLWYGVQPIYFIAHLTLPIISLAEDGMATTMAFCGFSLPPGGLAFLRWFFRMRYFEYLAAGWIIISLEDTLVLWSSLGYFVQVIGFLLSLAHLTLGRFVSAFERWTVENPGEDVAEITARNLSQTGKAWEPPVTDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZD9</accession>
    <name>A0A3P7EZD9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007107">
        <property type="protein sequence ID" value="VDM26753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZD9"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="29" mass="3208" checksum="09433C99F27C2028" modified="2019-02-13" version="1">MRIAALVKLVQGEEEHLTEQDKSAVSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EZS0</accession>
    <name>A0A3P7EZS0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007373">
        <property type="protein sequence ID" value="VDM26913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EZS0"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM26913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="119" mass="12678" checksum="E51302C16E31F84A" modified="2019-02-13" version="1">MAVIGNDGDFRVWDLKSETVLLHTTLQTPSSTSRRLQGEGDGGDVEMQDEPISDSLSGFLCMAAPQPDVSATANIVDIVAVAGHELIVFVPCRPPPLEEISEGSKKIPLTAFELSSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F5I0</accession>
    <name>A0A3P7F5I0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003418">
        <property type="protein sequence ID" value="VDM23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F5I0"/>
    <dbReference type="OrthoDB" id="6141884at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19829" checksum="F91390251B12A10D" modified="2019-02-13" version="1">MADCRKACPLIAAMCICMPWDVLQTSDKLEKSLDWFLFNKPLTYGLRRVVMRNADVLSKEYDVPRILKSRSIREFDDNFTAGMFGYKSAKEYYASASTITKISHVCAPILCLNAADDPFVPFNCESLLQFEKIVCVSPTLLSCSVPDLMQMNKFMHVFVNKLGLVEFISYHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FAP5</accession>
    <name>A0A3P7FAP5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005451">
        <property type="protein sequence ID" value="VDM25739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FAP5"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="175" mass="19620" checksum="423AB6F0B2462FFE" modified="2019-02-13" version="1">MLLQLVFSLIKDYVQRPKYAALRKTNLFFTYDRQPFDVGDWYRTVRLNPAANHNEGRHTPISPASSTVTLSPDGNRSWLDSEIDARRNNQRETSLTRRSPAPLPFDPPNHLLWKEYVSPNWQKSLVCSSARSQTLPPPGASSLRHASPTPPPLSNAFEKSGVLGSNSSGLFAIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FCC5</accession>
    <name>A0A3P7FCC5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006468">
        <property type="protein sequence ID" value="VDM26389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FCC5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="314" mass="34969" checksum="168B7745560E5B18" modified="2019-02-13" version="1">MEPKQSKFISVLYYSFLVHGSPVLIISKGSGIDLQDLISYTGGITEKSAIFYTSEIICGLEHLHALQIVHLDIKPANVLLTDTGHVMISDFDRSYDITREAKPPTSLDFTGTAYFMAPEIIQRKVITTKADVWSLGILMAVLVCGLKRLKPSTLNEITESSKRGTLAVKVFANFSGPLKSFFNACLQYHYRGRASVAALKRLRFYKSVDWNQVAAGGTRPPYKTSEIPKPASRMELKADPHDPSILAAAYGKDSPQVNGHFLCKKDGKNKWFLRTHPPSLFKLPVARKVLKKDNGCITDFHFINPRLSSNVHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FEW6</accession>
    <name>A0A3P7FEW6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS5396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01007339">
        <property type="protein sequence ID" value="VDM26887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FEW6"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM26887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19566" checksum="2ACA4F34EC78C4A3" modified="2019-02-13" version="1">MHYSLHATCCCSPPAFQNWQLSFGRKFRSLKLWFVIRRFGVSGLQSYIRGHIRMAKYLEALLRADSRFEIVCDVVLGLVCFRVKDDNEATKELSKEIAEDGRIHLVTATVTRPNMEEVFVIRVAIVHLFTDEEICQFAFDVICELTEKVMRRRQSDLTAGTGGSANCSAPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FFQ7</accession>
    <name>A0A3P7FFQ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021142">
        <property type="protein sequence ID" value="VDM34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FFQ7"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="92" mass="10127" checksum="32320A089AC978D1" modified="2019-02-13" version="1">MSRAGVPAIPLSSPSVLLSRSILTRPAFVQKLYDRLDAAERSIDEEGKPGTNLPFDTKNPRRLALTMILFIGIAFNIPFFITYSQMKAAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FGP8</accession>
    <name>A0A3P7FGP8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021352">
        <property type="protein sequence ID" value="VDM35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FGP8"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="178" mass="20044" checksum="12A3FDBF6EFE52A2" modified="2019-02-13" version="1">MKEAMHNITYNPQDESVRFLCDIVGQPIPNITWYRGNKRIRPDDGRGKYRIKPKLWGTAPSDKTTHLFCLANRLSCSTVDFYDLFGTSMKAASLPSRPRLRIKNPTPEDFGEYTCAAENAGGKRSTTAWLLPQQRQKARVKFLESPKRLMSVGFLEPISSLAASHYKFVCGVCGLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7G1E1</accession>
    <name>A0A3P7G1E1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS10184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021399">
        <property type="protein sequence ID" value="VDM35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7G1E1"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="135" mass="16038" checksum="A4AC4FBEC1DDF16B" modified="2019-02-13" version="1">MTLSVYQLAVKGVAAVSKTREIDVETDAEKLVNFCCINYRINEQPIPLKPDSEYPTWLWSLRVSRRPPRLADIDPDSYYYWRRIRRLHNRHLNNLAAADGWHRREHRDPRSHSERAYGDLSRALGKWLREHEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJN6</accession>
    <name>A0A3P7HJN6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021179">
        <property type="protein sequence ID" value="VDM34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJN6"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="177" mass="19151" checksum="669D7F91ABC097E1" modified="2019-02-13" version="1">MELAKFGVECISLSIVSLFLAEIVLKLWIFGIGLYLHSLIEGIDAVVICVSFGIDVYLMVTENHRHPISSLSTSHTLAMTTTSAPETTLRSGIKSLPEAAGFLVLFRLWRVVRIANAILVSVSATQETKIQELKAERDKAASRVSQLENFILALGQDVPSDSNSSPAKSTPLPPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI13</accession>
    <name>A0A0R3WI13_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NTP_transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS208</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000013">
        <property type="protein sequence ID" value="VDM16073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI13"/>
    <dbReference type="STRING" id="6205.A0A0R3WI13"/>
    <dbReference type="WBParaSite" id="TTAC_0000020701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000020701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000020701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="316"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000020701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50088" checksum="FED63DB6DB95E2F5" modified="2016-01-20" version="1">MLVKKTVKAVILIGGPAKGTRFRPLSLEMPKPLFPIAGYPMIYHHIEAFSKIPNMKEIIIIGFYQPNEILTRLINDTEKEFGISIRYLQEFTSLGTAGGIFQFRDQISAGGLDLLFVMNADVCCDAPLQEMVDFHVSLNSVDKFVILSTEATREQSMEFGCLVENPETNEITHYVEKPDTFVSVRINCGIYLFTPSIFKFIRVAFLEHQDQKFTKPGGTCKESIHLETEIFQPLAGSGTLYAFHTERFWSQIKHPGAVIYANRQMLALYHRTHPHRLAVHRDTTSTNGNIAIDTTDITTEASGDNETTTTSSARILGDVYLHPTARVHPTAVLGPNVSVGAGAVIGAGVRLRDTIVLRNAEIHANACCLNCVVGWNAVVGRWARVEGTAPFGPNPNTPFTKLEVVPVFNAKGQLNPSITVIGSNVDVPPEVIVLNSIVLPHKELSRSVKNQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIG7</accession>
    <name>A0A0R3WIG7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS392</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000032">
        <property type="protein sequence ID" value="VDM16350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIG7"/>
    <dbReference type="STRING" id="6205.A0A0R3WIG7"/>
    <dbReference type="WBParaSite" id="TTAC_0000039101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000039101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000039101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM16350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000039101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25487" checksum="19DD3E9E4800C1E6" modified="2016-01-20" version="1">MQQDDEVESRGRARAKRRFSLILQDLEYQLMFLSASVAEPPRTQTPNQEEAFTRIDTTKHWAIRSPLDEYREEPQESRLVTVFFNSTLRCFECDEELDSQCQIYRGKALCSQCFLTTPEIAVCCACHHTIEDRVVLALGKVWHPHHLKCSKCEEILSGGGHFYERDGEPLCFHHFRGLTQEVCHKCHNLLPECLVEFTNKLYCLKHFTCEFCDKLLQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIM3</accession>
    <name>A0A0R3WIM3_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dynamin GTPase</fullName>
            <ecNumber evidence="1">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS459</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="1"/>
    <dbReference type="EMBL" id="UYWX01000040">
        <property type="protein sequence ID" value="VDM16481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIM3"/>
    <dbReference type="STRING" id="6205.A0A0R3WIM3"/>
    <dbReference type="WBParaSite" id="TTAC_0000045801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000045801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000045801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="516"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="12">
        <location>
            <begin position="652"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM16481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000045801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="960" mass="106129" checksum="8F6766723A362A15" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIP7</accession>
    <name>A0A0R3WIP7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0506 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS486</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000043">
        <property type="protein sequence ID" value="VDM16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIP7"/>
    <dbReference type="WBParaSite" id="TTAC_0000048501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000048501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000048501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5021976at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021712">
        <property type="entry name" value="UPF0506"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11703">
        <property type="entry name" value="UPF0506"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0960">Knottin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UPF0506" evidence="6">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0506" evidence="6">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000048501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15087" checksum="7C0D2BDA73091646" modified="2016-01-20" version="1">MLSRLTTSDSSSLICLLFKDSCKRMGERCDRTVFNRCCEGLYCVLKGFADGSCEKCLPQGHFCFSDAECCSDCRREGEDCSRTIFSRCCDPLFCQLHSFAQGKCVKCLAGRQFCMSDSECCSGKCHWYRICSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJG5</accession>
    <name>A0A0R3WJG5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgi phosphoprotein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS814</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000104">
        <property type="protein sequence ID" value="VDM17030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJG5"/>
    <dbReference type="STRING" id="6205.A0A0R3WJG5"/>
    <dbReference type="WBParaSite" id="TTAC_0000081301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000081301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000081301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM17030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000081301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32798" checksum="847A0D8FB6A567B0" modified="2016-01-20" version="1">MAGTGETVVFRRNTRRDGSSSSDINLALQDDKQRGDDSKQTRFTLMEEVLLLGLKDREGYTSFWSDNISLGLRGCFLIELAFRGRIALEPPSARRLILNRNVIVVKNVPTGDMLLDEALRTISSNNPADAKSWIDYLSGTLFFLITQLLGDTWNPFKIALQMRNVRERIAKNLVEKGICSTEKQNFILFDMTTHPLINTPAKQLIIQRINDALLCNWTTDIQRMDRRLLSLIVVSQRADVLENAFLTLSNQDYNTATKHVRTLMDLNYNDYGSTGTPADVMWAVFAALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKF0</accession>
    <name>A0A0R3WKF0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS1189</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000208">
        <property type="protein sequence ID" value="VDM17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKF0"/>
    <dbReference type="STRING" id="6205.A0A0R3WKF0"/>
    <dbReference type="WBParaSite" id="TTAC_0000118801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000118801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000118801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000118801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30726" checksum="5F663136C704DD4C" modified="2016-01-20" version="1">MEDVAKVHVHPVVLLSIIDSYERRNEDAQNVVGTLLGTFEKGIIEVTHSFSVPHKESKTDVSMDLEFGRAMLNLERKVNRNLRPVGWYATGSEVTESSLLIHQDYYMKHVKNPIFLLVNPNLEIGKKMSIQAFQSRPIGIPDGTMGTMFLSLEVNLEFFDTERCAVDMMVADSLNKENQLSEAADDLSYLYKLTGRLLSMLERVNKKVEAFANGEQPADSELGMAIARLIFSTPKLDSDNVEDLISSSFKDLLMVTYLTNLIRSHTKLLSLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLB5</accession>
    <name>A0A0R3WLB5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1540</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000367">
        <property type="protein sequence ID" value="VDM18178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLB5"/>
    <dbReference type="STRING" id="6205.A0A0R3WLB5"/>
    <dbReference type="WBParaSite" id="TTAC_0000155301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000155301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000155301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132897" evidence="10">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000155301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24337" checksum="E213A6A3426D5FFF" modified="2016-01-20" version="1">MRLFVGTLFTILASFLTVLVDCFPKQLTFELPGTEKLCFYEKLEKQEQCSFMFQVLKGSSSDVEVVIRDPNTNVIVKKEESPHETIGLTATADGDYSFCFHNRFPPMSPKRIFFELRLDESLREEAGLLGSGPSSMIGTLAETIHEHLSVSESYQTELRAKLTADRIFAHELLSHITIWSTAVSVIIIVTVVAQLSILKSFFKDRERLHMTHNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLU0</accession>
    <name>A0A0R3WLU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Replication stress response regulator SDE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS1715</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000464">
        <property type="protein sequence ID" value="VDM18434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WLU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000172801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000172801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000172801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2/SF3A3 SAP" evidence="10">
        <location>
            <begin position="284"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM18434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000172801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39236" checksum="24BEC415289C0EAA" modified="2016-01-20" version="1">MMCSSANVTERRFITRKEYLVLFNMGVDCYFSVGGRLINHPSDVEDEETLVQVHPRLRGGKGGFGSMLRAIGNQIEKTNNHDMCRDLSGRRMRDVNAEAKLKEWYAKAGERERAKVDRYLEKQRRRREALDKGLLHDHKFNDPDFAKRKEHISAELQDAVEAMLSQVVADAASSEPAKKKAKLWIEQLDEDVSSSNDDGSDGNDSDDSSPLDLTEKEDHIAPSLESIANSETNLEFVSNKENDEKVTEQVVLTEEVLAESQNEGNVTMTSEKEVSPVTGRPSEAVSITDSVLDAASSAVELESYGLEVLKQALSCRGLKCGGTLSERANRLFSVRGLDPSQYPAKILAKPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WMR3</accession>
    <name>A0A0R3WMR3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LAM_G_DOMAIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2038</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000702">
        <property type="protein sequence ID" value="VDM18778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WMR3"/>
    <dbReference type="STRING" id="6205.A0A0R3WMR3"/>
    <dbReference type="WBParaSite" id="TTAC_0000205101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000205101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000205101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268171at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132907" evidence="1">
        <location>
            <begin position="28"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="335"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000205101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="571" mass="63879" checksum="69F5C9D725B04559" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN47</accession>
    <name>A0A0R3WN47_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS2173</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000821">
        <property type="protein sequence ID" value="VDM19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN47"/>
    <dbReference type="STRING" id="6205.A0A0R3WN47"/>
    <dbReference type="WBParaSite" id="TTAC_0000218501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000218501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000218501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
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        <property type="term" value="F:TBP-class protein binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00382">
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    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="90"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="184"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000218501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31563" checksum="4628F012CC7687BC" modified="2016-01-20" version="1">MVCSMCGLVVAERVIDVGSEWRTFSNDANAKDMSRVGAAENPLFDGGDLSTMISGTSYNDMRQFDEQGRALYRNRRNVSGSDRALINAFKEISQMAERLNLPKSISDHANLLFKQVYETKNLRGRSNDAVSTACLYMACRQEGVPRTFKEVCAVTRVSKKDIGKVFKKILKTLETNVASVSVEDFMTRFCANLNLDIAVQQLANTVARRALNLNLVSGRSPVSVAAAAIYMAALALGCRKEKKEIGDVAGCAEATITCTYRAMHPRAVELFPDDVRLCIRPEKFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNG4</accession>
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        <submittedName>
            <fullName evidence="3">DNA_pol_B_exo1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2289</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000929">
        <property type="protein sequence ID" value="VDM19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000230201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000230201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000230201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285070at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000230201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="539" mass="59255" checksum="C50AC456901399BA" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNH3</accession>
    <name>A0A0R3WNH3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyco_hydro_30C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2298</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000938">
        <property type="protein sequence ID" value="VDM19559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNH3"/>
    <dbReference type="WBParaSite" id="TTAC_0000231101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000231101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000231101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000231101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="259" mass="27804" checksum="1D36AED8A31159C2" modified="2016-01-20" version="1">MLELHAKALAPAGIQAAHFTYFFETTTPPPKRESSVFPRIAKKSYGSNVNVKEGGQNESAFLSSNLRFLCPVKMNVLTFYGQQLMCGALNAPPPPPPPPPPPPPRSHQPRIANNCMLHDDGASLIILLNKNKSSQYTVPTDNAEVTISDSVGDRDGGGGGGDDDDGDGGNWGLPPSSANLFISPPTQLGQSLVCHIKAPMHEEMKAMISPSSSSQQRFTVASPESSKRQWVHGVVLTWRVDCSETEEEVVLCGVVSQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WNS2</accession>
    <name>A0A0R3WNS2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ufd2P_core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001036">
        <property type="protein sequence ID" value="VDM19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WNS2"/>
    <dbReference type="STRING" id="6205.A0A0R3WNS2"/>
    <dbReference type="WBParaSite" id="TTAC_0000241001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000241001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000241001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000241001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14136" checksum="8DF01AB539976B08" modified="2016-01-20" version="1">TVSERAISFQHDLSAEVALRLCINSTGASFDPQAVERLRDVCQVLATLARDHAAKAVVPRSQSKLHQKARQMSLLLLPSVPVCRLLRAFAACNFDPRHPRWLHPREGLMPLRVAWHAMRRTSSVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPJ9</accession>
    <name>A0A0R3WPJ9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001367">
        <property type="protein sequence ID" value="VDM20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPJ9"/>
    <dbReference type="WBParaSite" id="TTAC_0000268901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000268901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000268901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6249806at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000268901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28138" checksum="447CFB4A17D9C88B" modified="2016-01-20" version="1">MKLRLKFGAHFKVAEVDEEALLSSLLERAASLFNLTTSNVLLSLNATDFYASSDGRLKLKDIGIVPGDIVYVQSLVQSDDIRKARSCEVLASVANYAIQKQMAIKYDNFFVDPEKIDADSRGNLSVIYKNPQDLIIKLSDELIEPILVDIHEGMVVNIFDRLPLTDLAYVTLSSRKVNAFINSCEALWRRKLVSIFGCSNADGRLVNQVYLAHIIKIFPNYLAFSFSYKLCVLARRFIGPAWQMSITFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPM8</accession>
    <name>A0A0R3WPM8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001406">
        <property type="protein sequence ID" value="VDM20937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPM8"/>
    <dbReference type="WBParaSite" id="TTAC_0000271801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000271801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000271801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000271801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10970" checksum="1D90FEBA0911BD74" modified="2016-01-20" version="1">MIFCGRLWRVNWVSLYLPTMLPKTLCVISLFLLVQKSRKPVLGQTFLIVVLTSLRFDIGSPFGPLIVTSIVCVYPMRLYMLLCRHLPLIIFRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ03</accession>
    <name>A0A0R3WQ03_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IgGFc_binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS2828</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001558">
        <property type="protein sequence ID" value="VDM21265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ03"/>
    <dbReference type="WBParaSite" id="TTAC_0000284301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000284301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000284301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6268680at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM21265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000284301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21059" checksum="AC28547820BA8FE4" modified="2016-01-20" version="1">MFLNDGRVVYGKLGSTFKYQTVLPGLYDRVVSGMHSVTIKDWDCSTPLFVCTIEEDMPYRSVATLTGTMNYGLKRVTFFGKYSIPITILFYTDHYWPEMDDHTFQWQYSLPLVTYAKDTDIVTLSAYILHVSAISLPNQPFASFKAKPDVVNDFISLLPMEEIVSYFLGSATRTSILSSLVWIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQG5</accession>
    <name>A0A0R3WQG5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS2993</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01001781">
        <property type="protein sequence ID" value="VDM21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQG5"/>
    <dbReference type="WBParaSite" id="TTAC_0000300501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000300501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000300501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF637">
        <property type="entry name" value="EAG-LIKE K[+] CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="35"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000300501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17667" checksum="9D4C72BFEB9E2EF6" modified="2016-01-20" version="1">MLPHLSTKNSIPEYKVQDLKASRCILLHYSILKIVWDWLIVLCTFYFAIMVPYNAAFQKDSNERTLRTLDMIIEVLFIVANAIHLGDESVAGVNHVGAAEPRNKSGQVVHHSKEIALNYIRGWFILDLIAAVPFDVIWTIQSPESPVVKFNIPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRB6</accession>
    <name>A0A0R3WRB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3291</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002194">
        <property type="protein sequence ID" value="VDM22329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRB6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRB6"/>
    <dbReference type="WBParaSite" id="TTAC_0000330601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000330601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000330601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000330601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31056" checksum="EB3489B7122369E3" modified="2016-01-20" version="1">MTYAFQTPEKLCFILDLMNGGDLHYHLTQHNVFSESEVRFYAAEVILGLEHMHNRFIVYRDLKPANILLDEYGHVRISDLGLACDFLRKRPHASVGTHGYMAPEVLQRGRSYDSSADWFSLGCMLYKLLRGHSPFRHHKVRDKHEIDRMTMTMVSAVPLNSPVWRAVPPPNILRRRVHASCCKLAICNFCPLISDLAASCVLESIIKRALHDIELPEDLSPEMYSLLSKLLARDVDCRLGCMGRGYVHQDPKKLLFCVRLFNLHLNLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS22</accession>
    <name>A0A0R3WS22_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3547</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002622">
        <property type="protein sequence ID" value="VDM22848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS22"/>
    <dbReference type="STRING" id="6205.A0A0R3WS22"/>
    <dbReference type="WBParaSite" id="TTAC_0000356201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000356201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000356201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM22848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000356201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9530" checksum="37084122354C8D6B" modified="2016-01-20" version="1">MGTLTPKPFLSSITGKKVIVKLKWGMEYKGYLVAVDRYMNLQLHSTDEYIDNCFTGSLGEVLIRCNNVLYIRECEDDSKTDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSH5</accession>
    <name>A0A0R3WSH5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS3700</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01002889">
        <property type="protein sequence ID" value="VDM23175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSH5"/>
    <dbReference type="STRING" id="6205.A0A0R3WSH5"/>
    <dbReference type="WBParaSite" id="TTAC_0000371501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000371501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000371501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM23175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000371501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36085" checksum="3F8C293881A003EB" modified="2016-01-20" version="1">MRPSSKKSKDLLSIKTGGIRFQRGKGQHILKNPLLIQSIVEKAGVKSVDTVLEIGSGTGNLTMKLLEKAKKVCAFELDPRMVAELQKRVQNTPYRRKLEITVGDVIKAKNWPKFDLCVANLPYQISSPFIGRLITVEHHYRAAVVMLQKEFADRLLAEAGSKIYCRLSANAQFHFKIAQLMKVSRNSFKPPPRVDSSVIRIEPRHPKPPVSFAEWDALLRLVFQRKNKTIASNLKSNAITASLRKNYLALLQKKNDSSGESCSPDPPEISEEGPTGLEAMHAKIRRILQKSGFESSRARSMDEDDLLRLLLAFRKEGIPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSI1</accession>
    <name>A0A0R3WSI1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor SYF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3706</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in cooperative interactions with calmodulins or calmodulin-like proteins. Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IQD family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002898">
        <property type="protein sequence ID" value="VDM23188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSI1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSI1"/>
    <dbReference type="WBParaSite" id="TTAC_0000372101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000372101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000372101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000055">
        <property type="entry name" value="Putative microtubule-associated protein futsch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF6">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM23188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000372101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24003" checksum="75C4AE6BB99F3D68" modified="2016-01-20" version="1">MFRGYNTRKHIQEEREHGMEISNPTSPDQPDPDLAATKIQATFRGYLARKELAQVLKHPDITICDSEKLSPDFVDLKLGQEKSTQKGLNDTSNKSSLQRVQDEEKRCNWTKTRIQTGYQVRTNLAQEEGSGASSPCVSPYLSEDEAATKIQAAFRGYQVRKNMRAQTAPIPRYADQKYDEAARKIQATYRGYRVRKEIGNLRRHLHGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSM2</accession>
    <name>A0A0R3WSM2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase-activating protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002973">
        <property type="protein sequence ID" value="VDM23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSM2"/>
    <dbReference type="STRING" id="6205.A0A0R3WSM2"/>
    <dbReference type="WBParaSite" id="TTAC_0000376201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000376201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000376201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274208at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000376201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19449" checksum="62A5B4DF63E83E18" modified="2016-01-20" version="1">MQDSAALIECLRTGNEPPGDVPITHLEVSDPPCGSSVDYSMSNHRSARLENVDNGIHYASIPVSPGPPANGGPFTGADPIVEPTETHRLPTVSATSYPTLSRSGRRFSMSSMGLGSNGNASAHSSFLWKVFSRRSKSREAERRSDVTPQNVRASGSQSQCDSPTKKLYVCQTFYLQFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTB4</accession>
    <name>A0A0R3WTB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3988</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003423">
        <property type="protein sequence ID" value="VDM23923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000400401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000400401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000400401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10444479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000400401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22371" checksum="3FDA58EF301F5627" modified="2016-01-20" version="1">MDCTLRFGEHYDLDERLKVFNVALRKDDIESAAKKAFQCPLCLFHAASRWALTEHAFFSHWLRLCYVCCHHISEAGTRKGGEQSIWEHTFSCLSRRHAALLRANTDDGDSIESLHDGPIWRRHQRVLHPQEDVKGTVPLQLPPHLDVVATAANCDDSRFADPPSGECASPSYWRKYAHFVATYLDTFHASTVHIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTR4</accession>
    <name>A0A0R3WTR4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4139</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003755">
        <property type="protein sequence ID" value="VDM24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTR4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTR4"/>
    <dbReference type="WBParaSite" id="TTAC_0000415401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000415401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000415401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000415401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="212" mass="21901" checksum="2A9EE0FB7C2B80E0" modified="2016-01-20" version="1">MVKTHEATRSSPAIGGHNTAKTISTDNEHSDDQAKTSMPSTTEPSAVADNDSECEDEEYNNEDVRHTKPTSHRSCAGGGGSGSANGSGNYAMGSQCLDSGMLLRQGISLWARSSSPGDSVEVVATATTSAPAGATGGPAPPHPTSSVTGAVNNRSYVNLQNPRPSAARTPLGKQHQAPASGGNAGANGGGSREYFYFCLLLLLYIVFDTDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WU76</accession>
    <name>A0A0R3WU76_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4300</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01004110">
        <property type="protein sequence ID" value="VDM24636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WU76"/>
    <dbReference type="STRING" id="6205.A0A0R3WU76"/>
    <dbReference type="WBParaSite" id="TTAC_0000431601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000431601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000431601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM24636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000431601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16101" checksum="56C0B70289178ACF" modified="2016-01-20" version="1">MRVKEVEELLQRSEHNGFPVVESLASRHLVGFVSRMDLIKALDLDRPHSSRRYSFNSIVCFTDRTPLLDQSNRMDNPEAFPLLADVRNIVDLSPTTLTQATPASTIFDVFRSLGLRQVLVTNLGRVTGIITKKDLLRFLDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVC8</accession>
    <name>A0A0R3WVC8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4704</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005134">
        <property type="protein sequence ID" value="VDM25488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVC8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVC8"/>
    <dbReference type="WBParaSite" id="TTAC_0000471801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000471801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000471801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000471801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30993" checksum="5A5AFD2FE59C3963" modified="2016-01-20" version="1">MTEPTHELKHLFRKPPEDFFFWLESQGVDTETRKLFEQHMIDGFTFSMLTMNDLREMGVVKIGILKKLVFLIDVWRSRHQSCCFCLGLLSDHDLDCSHCCESYQSSAVSSACELHPKIWKVIISAIYAFLSLGVTSFVMVLAHERLPDISKYPPLPDILLDNLPYIPWAFEAAEIIAVCLCLIWFTVLFFHKHRLILFRRFCSLLGTVFLLRSVTMIITSLSVPGKHLLTECRPFVFDSYGERLARAAEIWFGMGRRFHFTIDCQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVG1</accession>
    <name>A0A0R3WVG1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4736</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005205">
        <property type="protein sequence ID" value="VDM25553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVG1"/>
    <dbReference type="WBParaSite" id="TTAC_0000475101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000475101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000475101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6284045at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000475101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11992" checksum="B4E2DB66568CAA7B" modified="2016-01-20" version="1">MLDYRLSVFPKATAPVPTPDQSALASDDTEQICVSLDYVPDRGHMLWSRWVLILACLAQLLSAFGVIGCHAMDFSEDTKLEVGVSLGILAFGNIFGAVTLYLFLHQFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW66</accession>
    <name>A0A0R3WW66_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Lig_chan-Glu_bd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS4991</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01005882">
        <property type="protein sequence ID" value="VDM26016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW66"/>
    <dbReference type="STRING" id="6205.A0A0R3WW66"/>
    <dbReference type="WBParaSite" id="TTAC_0000500601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000500601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000500601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM26016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000500601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19150" checksum="A7B5A972DF9A9298" modified="2016-01-20" version="1">FCIDLLNECAEKLEFNYTVHPVPDGNYGTAKVIDGHEVWDGIIGQLQFRKADLAVAMLTINHERERVIDFTTPFMNLGMSIIFKKPEQKKPDLFSFLRPLSPAVSWLIAFYLFTIIIIYFYAFAVLHSANALVFPTSYGLANRFLLQAVLPKLEAAATAFLTSALVSSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWB4</accession>
    <name>A0A0R3WWB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5039</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006033">
        <property type="protein sequence ID" value="VDM26128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWB4"/>
    <dbReference type="WBParaSite" id="TTAC_0000505401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000505401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000505401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000505401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18806" checksum="11D736F6EAF9E4C9" modified="2016-01-20" version="1">MCRQSTAESTSTGEISSPCPLHAGLEQSPSLPHIGIGSSQQSQPLAMVNGGCRSGLNGSRPTPTPSRQQSHHQPGRWTGETPTPTATPTPTPTPAPLLMSQHPAPPWFQAYLPREVALELLMHEEVRWFCHSLLSVSVKPYFQPMHNLKDCYLYVATDINLIRFKRHYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWK4</accession>
    <name>A0A0R3WWK4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006332">
        <property type="protein sequence ID" value="VDM26325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWK4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000514401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000514401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000514401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10634624at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000514401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20269" checksum="B67E6336449F4A71" modified="2016-01-20" version="1">MENEEGEDVEGSGEAEQREEGTALITSTKLPGIPPPSIFDALFAESGKTQNTMETIEKNEAPREIGQTAPAPSNTPAVGDSGGSSMDLFKSIFASDEEIEDVDDAENEDMPPPPSSPEVLSSMTSLAHDKDNTDGNTAYKDDAVREAPISPPHPEPALPDLSVHKLFKHLFNPELDSGRWWSLYFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWK9</accession>
    <name>A0A0R3WWK9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Miff domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006350">
        <property type="protein sequence ID" value="VDM26331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWK9"/>
    <dbReference type="WBParaSite" id="TTAC_0000514901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000514901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000514901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6261177at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000514901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7640" checksum="3A2DC5F3251A6EAD" modified="2016-01-20" version="1">MAPSGTAGHNNIIERLRTAETRLSHLEAYVSRLSSRLRGVEQQQALLGGLITIYFGLKVVRFLVAALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWU0</accession>
    <name>A0A0R3WWU0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS5215</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01006636">
        <property type="protein sequence ID" value="VDM26492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWU0"/>
    <dbReference type="STRING" id="6205.A0A0R3WWU0"/>
    <dbReference type="WBParaSite" id="TTAC_0000523001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000523001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000523001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133084" evidence="9">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="170"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="317"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM26492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000523001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49129" checksum="D03EC17FE74B8429" modified="2016-01-20" version="1">MDCLKVWNLLSLLHCMTLAAELTFRLEEEVSSGKVVATNSDLASLLVTPNALPVIINRKSPGASSFSFVKRTQSGLELVVTGRVDREAICPAKSAISSGLRLDTSPRPLFHIEDPSRLLPFRSTFHDYDAMSPNSPASDCVVSLRVASGDKIFNVRIEILDINDNAPSWNSSTLYLSLRDGDPAGTILYLPLAEDEDVGLNGEITYSLQALDDDLHGGYSRAQLGLFELIKHCETSGGQRMPDIVLPHQANDQKLALRTKTSIDREQLPEIIQLRLVARDAGTPTSQQSSLKLVINVTDVNDNAPMFERAINKIDILSEDAPVGRTLLQLRAKDMDSGANAELTYRFESNGQPMLEVIRHFFEITPSGQLKILRRLNVDKMEGEQSLPSSTPISFGVEAVDGASPAYALTGRTTIQLQISDTNDEAPRILVYPVHPPKERPAGSTSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WWX4</accession>
    <name>A0A0R3WWX4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase_M1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5249</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01006760">
        <property type="protein sequence ID" value="VDM26559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WWX4"/>
    <dbReference type="STRING" id="6205.A0A0R3WWX4"/>
    <dbReference type="WBParaSite" id="TTAC_0000526401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000526401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000526401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000526401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12148" checksum="B9CBF4ECAE074EBE" modified="2016-01-20" version="1">MLHNYMGPCLFQAGLKTYFEKFRYANARTKDLWTALETTGIDNVAEVMTLWTKQTGYPVISVRLVHAPDGTYSIGIKQQRFLADGSSSKGGSLFFVTSVSRFNRLCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXR7</accession>
    <name>A0A0R3WXR7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007898">
        <property type="protein sequence ID" value="VDM27186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXR7"/>
    <dbReference type="STRING" id="6205.A0A0R3WXR7"/>
    <dbReference type="WBParaSite" id="TTAC_0000555701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000555701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000555701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229490at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000555701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23582" checksum="8602123858DC4EB3" modified="2016-01-20" version="1">MGYSHHVAVFFMETLISLLPGPLFRKFLQNHLLNMPSLSEYTTDGVSVVSVLASHENACRVLRAAIRAVKRASDLEQIMSALQLPGIGKIETGLRGALDSGQHYLLNALAEACHRCSGSRAEAVQATFEKILLEAFEYGQKMKVDDQLIKSIVRLKRQSELESSDGMEEEGKKLSAGFLFLCHLLRGQQLKHLDCTLAILLSAADGKLGERGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WY68</accession>
    <name>A0A0R3WY68_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transducer and activator of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5693</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008604">
        <property type="protein sequence ID" value="VDM27460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WY68"/>
    <dbReference type="STRING" id="6205.A0A0R3WY68"/>
    <dbReference type="WBParaSite" id="TTAC_0000570801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000570801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000570801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000570801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14474" checksum="5DBE8B91B662FC46" modified="2016-01-20" version="1">MPLENWPLFLAQLRQINDWLAHQDANFHQLKGTVGGDSESVSQLINSFSVLEEELRLQRFQVEDLLDRGQIFMRDQLSEGKYGFSTESEGKVMDNKWTPLFPLSTSRMQQFFLFLNCLLFPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYJ4</accession>
    <name>A0A0R3WYJ4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDE_Tnp_1_7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5819</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009203">
        <property type="protein sequence ID" value="VDM27733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYJ4"/>
    <dbReference type="STRING" id="6205.A0A0R3WYJ4"/>
    <dbReference type="WBParaSite" id="TTAC_0000583401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000583401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000583401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256119at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase ARIH1-like UBA-like" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000583401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16910" checksum="74AA6340C10E759C" modified="2016-01-20" version="1">MDESFVDLMSHSDSEEFPDDIDTEFYRADDCEDSLEYQNPEFIPLTPDMLVQYMLETVNAVHQITTLPKTIIRLLLDYFKWDKDALIEQYFEHSNPHNFVKSTILPSLVENNDDIPSLVLRSYTDAYGNGEFLWSLLLVFVSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYL8</accession>
    <name>A0A0R3WYL8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS5842</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009332">
        <property type="protein sequence ID" value="VDM27790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYL8"/>
    <dbReference type="STRING" id="6205.A0A0R3WYL8"/>
    <dbReference type="WBParaSite" id="TTAC_0000585801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000585801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000585801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9979034at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="28"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM27790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000585801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30148" checksum="526B6BADE08BE216" modified="2016-01-20" version="1">MAVENDVPRRVIQLQLTCWDKLKVPRRDDFYIFLKTYWDDFNAVNKQSTDSVLVHCSGGVGRTGTFIAIDMLARYLQRVMGMEEKKSVGEAMAAEDDMSWHESVYENMRESEKPIPLYNCAALDQSTSTLDIYHTVLWLRSQRFKSVQQDVSRLSTSSVRCIHASQFYSSQCRFSHQRLKPTPTPHTFEWSEDRHAAVLSPSCTTSSPCKRFTRPLATLRIHRQRRPKLIVACMLMGRTEQITACPIFWPFRYNTSSSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYZ1</accession>
    <name>A0A0R3WYZ1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5971</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01010013">
        <property type="protein sequence ID" value="VDM28086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYZ1"/>
    <dbReference type="WBParaSite" id="TTAC_0000598101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000598101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000598101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000598101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8580" checksum="F06DF5D035F1C936" modified="2016-01-20" version="1">MRFQWHNPNGTLISNQWFLRLADMSIYESGVYVCTVSVEVNGTQREASRGTNIQVKPGKTDTVITGGSAQTPHVVSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZG0</accession>
    <name>A0A0R3WZG0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TTAC_LOCUS6164</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="UYWX01020294">
        <property type="protein sequence ID" value="VDM30326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZG0"/>
    <dbReference type="STRING" id="6205.A0A0R3WZG0"/>
    <dbReference type="WBParaSite" id="TTAC_0000617901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000617901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000617901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="57"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="219"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="487"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="586"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="668"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="720"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VDM30326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000617901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1193" mass="135874" checksum="B288DFEE52736703" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZN3</accession>
    <name>A0A0R3WZN3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS6255</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZN3"/>
    <dbReference type="STRING" id="6205.A0A0R3WZN3"/>
    <dbReference type="WBParaSite" id="TTAC_0000627001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000627001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000627001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM30439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000627001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47632" checksum="938801092E736D82" modified="2016-01-20" version="1">MHVAESEDIIEERVINEEYKIWKRNTPFLYDMLMSHALEWPSLSAQWLPVVETTDEDYSIHRLILGTHTSDEQNHLLIATVHLPNDSAEFDASTYESEKGNFGGFYFPSGKLEITMKINHEGEVNRARYMPQNPDIIATKTPSGDVLVFDYANHPVRPSSELGSQPDLRLKGHQKEGYGLSWNATHSGHLLSASDDQTICLWDISGSPLDGRCIDAMAIFTGHHSVVEDVAWHLMHGHIFGSVADDNKLMIWDTRSASRNKAQHQVDAHTAEVNCLAFNPFSEFILATGSADKTVALWDLRNLRLKLHSFESHRDEIFQVQWSPHNETILASSGTDRRLHIWDLSKIGVDQTTEDAEDGPPELLFIHAGHTAKISDFTWNVNEPWVICSVSEDNILQIWQMAENIYNDEELDIGGMELGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZZ5</accession>
    <name>A0A0R3WZZ5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Partitioning defective 6 homolog gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6393</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZZ5"/>
    <dbReference type="STRING" id="6205.A0A0R3WZZ5"/>
    <dbReference type="WBParaSite" id="TTAC_0000640801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000640801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000640801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5868434at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="149"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000640801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="318" mass="34590" checksum="B8CF45BDB5CA0E41" modified="2016-06-08" version="2">MTVLAVKSKYNAEFRRFHLDRSVVTTFADLYRIVEKAHGLYNAHFILQYVDPKENTLLPINNDKNCERALAVASDPLRLLIQLKGESYGEIKGYKSPGTVFLRKKPADIVRSIGSEKIKPGHQSIILCDDFHKVSSIIDDGTLPECMRRVHLIRTGSKPLGFYIRDGFSIRATPTGVQPVPGIFISRLLPGGLAESTGLLAVKDEVIEVNGIEVYGKTLDQVTDMMVANSSNLIITVKPFNQKTCIHRTKFMAPVSAVAGSVSNQGSAASTSHHSSASSSSTAAGVAEVRRQVLPSRDSPKSPVQAHTVPEVPGTIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X025</accession>
    <name>A0A0R3X025_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Otolin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6431</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020303">
        <property type="protein sequence ID" value="VDM30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X025"/>
    <dbReference type="WBParaSite" id="TTAC_0000644601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000644601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000644601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256523at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133089" evidence="2">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000644601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34193" checksum="9418A5F7045C3D9C" modified="2016-01-20" version="1">MKWYLIQLHLIVAASITQIPLIHTSKFDYDTASTSSAKSRGRTSQTALTECHLQVECTAPQTSHLAANESESLGMVRKIRIPVRAARGPQGPRGLRGPAGPRGPPGFSPEINEDIVTNGRVKRRVTSQRLPSYTPPERHFIVWRLEEQRDYEDIHILELRVGAHGFSDRLASLEDFAGTCSIEMVRPNSSGAQYCFSLESMLPELISTSVGIVIDWDAIEGTTADEIWRAFQQRLVDETVFRPVIAAYSAQFRSAEAFSAWQRNLQDNTRRRDSERNSGSKPCLFEFRFPLLLISGWLWILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0H3</accession>
    <name>A0A0R3X0H3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein krueppel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS6616</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020311">
        <property type="protein sequence ID" value="VDM30850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0H3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0H3"/>
    <dbReference type="WBParaSite" id="TTAC_0000663101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000663101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000663101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8918594at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM30850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000663101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="430" mass="47019" checksum="5B78A73513A2E74E" modified="2016-01-20" version="1">MDASNELANAAKVDPDGYTLDDDVDLTNITPMPKHVFLNTLPGHLAPFPTIPRSRYDTDRNQREFYGQESFLNAFITTHCRDHTSAANVNGLTDSQQHQLSQQQQQNRRGSSAPLKRNQCSLCFRVFANSASLKQHMRLHRGEKPFKCRFCDKTSATMCNILTHERTHTRERPYKCTLCSADFSSSSNLKVGLRRTHMRTHSGDRPFRCNLCDRRFVTSNALTTHLRAHWGLRLHPCPDCDRQFSTSSNLRVHHRTVHLGIKQYHCVVCGKAFATSSNLNAHSRQHPESAYLVKYAGPSSFCPSTQQSTNTTTVNTAAVESTVATTVTVATTTAAAVVVSAATAVAGEEEEEGGEESGEETGNMLVTPTGYNHAPTLLPVALSPSPVGPSRKFAKVTVYCPGDVEIAATATSSVSSSASHANTAKLAPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X0T3</accession>
    <name>A0A0R3X0T3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Echinoderm microtubule-associated protein-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6753</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020320">
        <property type="protein sequence ID" value="VDM31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X0T3"/>
    <dbReference type="STRING" id="6205.A0A0R3X0T3"/>
    <dbReference type="WBParaSite" id="TTAC_0000676801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000676801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000676801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269842at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21931">
        <property type="entry name" value="TD_EMAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049813">
        <property type="entry name" value="Elp-1-like_TD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000676801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25126" checksum="107EAC6351D226F2" modified="2016-01-20" version="1">MSNGAVGLDGLVTAEKDELLERMAYLEKQTTDLAEELICLKSALADCLRRVQLLESSRGTHSPTSSRVVPRTASESRASRTPTATMVGRQSRHMPRMPSTSAASSARRPPSQASTRPANLVSPSGNAPSTLPSFKTSGSTGSVVRPPTGVSKSGASFGCVDFEDPYEPSSWSTIYGLPTAPRMISQRTLLRRPTSTRYSAALHRIRRNSMPLNSVTASSIWSSQVDTGCYCGAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X148</accession>
    <name>A0A0R3X148_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RPOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6881</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020328">
        <property type="protein sequence ID" value="VDM31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X148"/>
    <dbReference type="STRING" id="6205.A0A0R3X148"/>
    <dbReference type="WBParaSite" id="TTAC_0000689601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000689601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000689601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000689601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55962" checksum="282A518FC6B81079" modified="2016-01-20" version="1">MSGRSGPLISVNQHGLSFFPSVQEEWSADKFMSEFQVVVTSFTPETIEFDLINIDCTFANAIRRILIAEVPSFAIDRVFLYQNTSVIADETFSHRLGLVPLNVDPDKMGFCTTDLPDSDELSKFDPTCHLVFDLSVKAGRSSSKENGDCQSRENFRSFPLYSLDALCNVRSDTGCYLVLLYYIVLTNEFCYSSSLTWVPLPGQEDAFKNEGASYPAPVSRKILLNKLGSGDEILARCLAVKGIGRDHAKFSPVSAAFYKLLPSIEIKGTVRGELAKKLQRSFAKGVIDVDSRTQLASVADARLDNGSREHLRHPDLANLVHVFLNPRHLIFTVESIAPGYRPPDTLVKCAIDVMLLKCAHYLTIVEKPGFAASPQCASTGDVVEAERIGEEAAKTSLNGRVVGLDVAFVSNDLRRATFHFTGEDHTLGAPLRYCILRSGTVKLCGYCQPHPLEDSITFEIQSRGEMAVVVLQKGLCCLRECFEQIKRKFKSAMKKVQKQASKSTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1B8</accession>
    <name>A0A0R3X1B8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6970</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020335">
        <property type="protein sequence ID" value="VDM31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1B8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1B8"/>
    <dbReference type="WBParaSite" id="TTAC_0000698501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000698501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000698501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976063at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="165"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000698501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="662" mass="69999" checksum="5E25A247764A9162" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1G8</accession>
    <name>A0A0R3X1G8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS7031</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="UYWX01020339">
        <property type="protein sequence ID" value="VDM31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1G8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1G8"/>
    <dbReference type="WBParaSite" id="TTAC_0000704601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000704601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000704601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF101">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000704601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57764" checksum="4FA5BBBAEAD236CF" modified="2016-01-20" version="1">MLFTLSTRCRGSEQVKMAKKSGLNTSVIIVFHNEAWSTLLRTIHSVLNRSPPKLLQEVILVDDASDRDYLGASLETYVDALGEQVRLLRLRERSGLIRARLAGAREARGSTLTFLDAHCEVTLGWLEPLIVHVFSNPHSVVCPAIDVISDTTFEYLQSTERTWGVFSWDLLFDWDVVSSREEVRRHHNPAMPIRTPAMAGGLFLIRRDYFYSASRIHILSCELGAYDEGMEVWGGENVEMSLRVWQCGGELLIIPCSRVGHVFRKVSPYSWPGGVTHVLHRNRVRTARVWLDEFIELPFTLDPFRLHFSSRKALRTFEFGDVSERIALRRRLKCKSFSWYLQNVFPESNIRPRIERLGQIRNPVHELCFDTGGGRKGQVISAAACRSISSGSSAQQTFTVSTAGELTASVGCLGAQHIRDNLILGQCDGDAGAFQKFIYDDQVELHNFLYSMAASRQSTSSTSTQIFASVWILHGGSCPCFLFLYLDHCATSDEFIWELPPPFHNQTLRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1V6</accession>
    <name>A0A0R3X1V6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS7206</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="UYWX01020353">
        <property type="protein sequence ID" value="VDM31548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1V6"/>
    <dbReference type="STRING" id="6205.A0A0R3X1V6"/>
    <dbReference type="WBParaSite" id="TTAC_0000722101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000722101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000722101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133154" description="procollagen-proline 4-dioxygenase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="464"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM31548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000722101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="596" mass="66839" checksum="FD655FAD86152153" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X263</accession>
    <name>A0A0R3X263_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7341</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020364">
        <property type="protein sequence ID" value="VDM31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X263"/>
    <dbReference type="WBParaSite" id="TTAC_0000735601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000735601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000735601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6227221at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000735601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24425" checksum="CB5BAA45F4F8854A" modified="2016-01-20" version="1">MDTDIYVLHAFYCGFCSIRHQPLDQNDIPDYLARRVQMKPRVNCTIHGDICGFVVTTAKSRAFPAAVINGYIALNNAAHTVAVRHCETDHFLAGYRFFSFNNTHEQDYFVQYLDTILDSHVSMFKRNSALYYDYPMRGGMGESRKPFGAYNIPLGQMQYMAAPVPTKMHREQLRKKSRKNSQRPESEDRYPIDRLRRMAHIRNLQTNGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2G1</accession>
    <name>A0A0R3X2G1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020374">
        <property type="protein sequence ID" value="VDM31840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2G1"/>
    <dbReference type="WBParaSite" id="TTAC_0000747501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000747501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000747501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6248794at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000747501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55527" checksum="7F4E60FB2312BD2F" modified="2016-01-20" version="1">MTSTFVAASSPNVRVSYSRLYQLPERDQFETNPTLDDEAQPIGWDRRYGMLFFSERALLYGPYSVATAEEKFILSQFPNFMRDRGKKCLYRIFEAYTAIKLGRSGLRARPRDPATDRVYYFPSHYPSCIALSVLHYDGDSCRTCAALIYKFRTPEVAALAFKMLTDTNSVPRGRRTSLSPATFPVAQFLTKSSPTRAPSRRNGSTRRVQEREVKIAAPRCSVRQSRSRQIDIQSSPHWGASYIDFEGSKRKLESPEKIFRGRSHHRSKSRSKGQKGLVHLQHQNCCCCNHQCIHCGGVKNCHSAAKGLKGNIPKIEDGSLLIINGKKYPLSLLHELVDQFDETAPAFRLSESKSTTSSDSSSSNNINGVGVDNDSADSGSGSGEPVVELVFDKLKNTSKLNGTEMTFCNRVSSRNGMRGDGGTPVTVIRLSRQGHSDSEQEDGINGCGYLASPTKVLGDGTTVYNLYGRQRSEDRTIKQFNNPTFTADETPDETPDENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Y2</accession>
    <name>A0A0R3X2Y2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EamA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS7661</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020392">
        <property type="protein sequence ID" value="VDM32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Y2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Y2"/>
    <dbReference type="WBParaSite" id="TTAC_0000767601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000767601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000767601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000767601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43212" checksum="D721FA8C61DB37D3" modified="2016-01-20" version="1">MPICEVDQLPTNGNSRLCQTGPQSGDIDSLSSCSNDSFGILTPSAPSRFLHYLRRLAVPLALGQFLSALIAVTGIASNYLVRFGVSLPLTQNLPHYFLLTIIYGIFSCHRFLSHPTETLHTRSLDLWYFLRSRGWQYFIAGTIDMHANWAIVSAYGYTNLTSVQLLDCLTIPTAMILTRFCLKTHYKWVHLVGVIICLAGAGAMVGADYLAAKDVDTGVGSEAASAVSQTSSVMFGDFLVIAGAVGYGASNVYQEHLVRKFGIIDYLSLTALAGTFWTAIYCIVVERKKIAIELTHLSENLNLAASLGCLAGYAAAMFLLYTTLPFALSKTNSVLVNLSLLTADIYALLIGIYLFGNIFHPLYLVAFGAIMVGLCLFASRDPILRDTVATPLNEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X2Z2</accession>
    <name>A0A0R3X2Z2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARF7EP_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS7672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020393">
        <property type="protein sequence ID" value="VDM32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X2Z2"/>
    <dbReference type="STRING" id="6205.A0A0R3X2Z2"/>
    <dbReference type="WBParaSite" id="TTAC_0000768701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000768701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000768701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5984406at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536:SF3">
        <property type="entry name" value="ARF7 EFFECTOR PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000768701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21163" checksum="0FFB5DA35FA20533" modified="2016-01-20" version="1">MEKRKKKQVCRKSTALSQSISSAEVSRLKFLNPGKQNEDLTLSWDCGSITRGFKRQHTLHIQGIGVAQASASATAELDRLRFINPGRQNTDLKPINWTQEGVYMTRGHRRQMELHAKLCEANSSDPPLYDSRGLLLSNMQDRCDCMRLDCPGCFLPCRRCHTTKCGPLCRIMRNFHYEKVGSGSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X3Q8</accession>
    <name>A0A0R3X3Q8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS7980</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020427">
        <property type="protein sequence ID" value="VDM32461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X3Q8"/>
    <dbReference type="WBParaSite" id="TTAC_0000799501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000799501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000799501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000799501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1309" mass="144255" checksum="0B95D91A71086B9B" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X469</accession>
    <name>A0A0R3X469_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clarin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8176</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020459">
        <property type="protein sequence ID" value="VDM32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X469"/>
    <dbReference type="WBParaSite" id="TTAC_0000819101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000819101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000819101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000819101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31995" checksum="1452D07FF405C6FC" modified="2016-01-20" version="1">MAKEGATSKNSGGAVGNGEPRLRHQRKRPRRCAIGCYHASAVILLIGIIVALAGVSSSRLFEIFIYDNRHPPLFHHISIHVGLFDIRGEITGNDAISVVEVLEYPPVLDEPRWLTAKAATVIGLIFGFLALIIHTALLCCHRGQEDKPCGTVAVEVLFYLITVIGLLVGLSLAESEIEGVHNHGDETLVRMLQANRLIGSATEIDKSALPSDTSEVLHTPTSLSSGYVAEFNLVLSNPQQSFYVLIAADFICLLAFLMALIYFVRLSERKEELRKQLQKAKVAKPVSERPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5A1</accession>
    <name>A0A0R3X5A1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS8612</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020545">
        <property type="protein sequence ID" value="VDM33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5A1"/>
    <dbReference type="STRING" id="6205.A0A0R3X5A1"/>
    <dbReference type="WBParaSite" id="TTAC_0000862701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000862701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000862701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000862701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14666" checksum="98CC4EB12F8EBA59" modified="2016-01-20" version="1">MPRSSALKLKYRRRDLDQIYEDQKPENISKRLRVATEIDEEKPALGQIYCLSCDKYFCDVPSLKAHEKGKPHKRRVKDLSVEPHTQDVADWAAGTGPPPKILRLHDRLSTELKATKPAEEPSELRSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5G6</accession>
    <name>A0A0R3X5G6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8693</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020564">
        <property type="protein sequence ID" value="VDM33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X5G6"/>
    <dbReference type="WBParaSite" id="TTAC_0000870801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000870801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000870801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064659at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="219"/>
            <end position="241"/>
        </location>
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            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="591"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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            <end position="1208"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1432"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1451"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1535"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000870801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1570" mass="167715" checksum="407C6DF0007C07C3" modified="2016-06-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5R0</accession>
    <name>A0A0R3X5R0_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS8804</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020592">
        <property type="protein sequence ID" value="VDM33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5R0"/>
    <dbReference type="STRING" id="6205.A0A0R3X5R0"/>
    <dbReference type="WBParaSite" id="TTAC_0000881901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000881901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000881901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000881901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46095" checksum="E0952EB9BA23A607" modified="2016-01-20" version="1">MRQSPDDAVTELDELEMDEDKELDAEVNISEMLDEEVPEEEEEEAEDEETEGEAITRIEEEISERIETANSNADEVIEAFTEAKIPHFSIRADDQLTRVRYRLVKKIKNVIINREAIFERVYPITLEEGENLVASGFKHLSPFSRFCPVSWDRVSIARLPPLNPSPILRYSRLDPRLVEPQLGDEIAPSMPAKKGKKRSANGVKTCCAVYRECVYWFVSEAERKVFIANPISVIRRAGEQIHTLVHQPLEVAVTGGPTSEREFISRRFGTDLHVAYVTTAGAIQWLLRSVCQSWTTLARQIHEVLISGAAICDDLVAKALRVALYAPQIQARGYVLDNYPITVDQAKFMHAASIRPFLMLELHSKHCNHPSIEVSWFDNWNNQEPPDCPFLKVWLNMKARRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6B3</accession>
    <name>A0A0R3X6B3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plastin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9025</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020658">
        <property type="protein sequence ID" value="VDM33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6B3"/>
    <dbReference type="STRING" id="6205.A0A0R3X6B3"/>
    <dbReference type="WBParaSite" id="TTAC_0000904001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000904001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000904001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21218">
        <property type="entry name" value="CH_PLS_FIM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="126"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="370"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000904001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54018" checksum="3532D21C6CD985E2" modified="2016-01-20" version="1">MPLDPFSDKLYEAVAEGVIPCKVINCLFSNAIDERAINMSNNLFYASHRVENLQLALTAALCNGCAVKNITVDDLMGTRPNFKLASLEFLKQVILKGYYQNINIHEHPEIFTLREVHEDINDLKCLSPEQILTRYVNYHLRSAGITNVLTNFEYDLSDCVVYAHLLYKIAPVTIRPRLLPDHQVLVYSNIENRAKAVLQNLRELGAEMFLCEDDFLHPEHQRKSRGVLHLMTVAFLFDRFAGEMKAHGGGDFPISKEDVNELSSRNFINSINVKPYCTHVISNLRDGLIAKQVFEVLRPGFTTGVKFTHEFDLIRRDAQFLQNNTCILRLVQGYSFRLPSLDASRLTTSDQEMCEVLLMEMLRSYLTHDAYDEHELLKWVNDQLARAGKPVELRSFQDRLIADECLFAVVLNNLTNGLASKDYLRGKRYENAKYYISVAHKAGFRVFTRPEHFDVCSPRWVAIAFAALRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6B5</accession>
    <name>A0A0R3X6B5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho-related GTP-binding protein RhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS9027</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020658">
        <property type="protein sequence ID" value="VDM33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6B5"/>
    <dbReference type="STRING" id="6205.A0A0R3X6B5"/>
    <dbReference type="WBParaSite" id="TTAC_0000904201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000904201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000904201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001799">
        <property type="entry name" value="Rac2 family GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000904201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19993" checksum="A5C2B63BFB777579" modified="2016-01-20" version="1">MTNSTIKCVLVGDGAVGKTCLLMKKVTGNFPTSYIPTVFDNYTVPIEIGKTTYRLSLIDTAGQEAYENIRRHVYPDTSVFVLCFSVTLRSSFCNVVDKWVRDIRSVCPTTPILLVGCQTDLRGGSNSTATPYSEGKKLAKDIGAVQYVECSAKTNDGVDDVFNKAILIGAGLKTRKRSRCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6R8</accession>
    <name>A0A0R3X6R8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Replication protein A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS9200</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020713">
        <property type="protein sequence ID" value="VDM33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6R8"/>
    <dbReference type="STRING" id="6205.A0A0R3X6R8"/>
    <dbReference type="WBParaSite" id="TTAC_0000921501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000921501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000921501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000921501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13772" checksum="3828496739F98C5C" modified="2016-01-20" version="1">MEKRGPRFRIVGALIPRLENREVCILGKALSVDASGQRITLQCADGTEVRLATPYYLTVFVKVSPELCIVEVQGLVTQAHEIQATADPVIFSQEASNNFDLERYAYAVNLTATFDGLYMQSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X6V4</accession>
    <name>A0A0R3X6V4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9242</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020730">
        <property type="protein sequence ID" value="VDM33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X6V4"/>
    <dbReference type="STRING" id="6205.A0A0R3X6V4"/>
    <dbReference type="WBParaSite" id="TTAC_0000925701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000925701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000925701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550309at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000925701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48572" checksum="89949133263DEA76" modified="2016-01-20" version="1">MSMLQLQETRVAQLLQTIRHQVGNPLQKRIRSVIKAWQKLLEPGSACATVIPLQRNINTSNNNGSTATKFSSSTPNITNSSPSTQSSNGRSKILRNQSSINHHNQEPPTKIPDRKKISSTTALPNGCSPKLPSSLNGRVSVITDVPKLAKVKSTAELVQEAGGCIDSVTKDRILSNRIAKESDEFPRLVPLAAMRSSRKAKHPPSTLPSTTHHHQKSVSRNADRILPPPPPPPPPPVTQPSPQCNLSIPPTKSEIIAKFLEHAPSQMESPRETRSISSDHNSRHHHHHKEKRKHGKRRRENKEEGDGEDALTEPKQPPVTNHMDDWPTLSPLTEEVMREAAATWLRDYHSGRTPSQTELGDVGRVADLLQGTWEEVSASRGDNGCLEPMTALYSVDMGDDQLVHILPWTNLGDYKQTFFPPGSTTASDLDRLIDLPEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7I8</accession>
    <name>A0A0R3X7I8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CLP1_P domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS9498</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020850">
        <property type="protein sequence ID" value="VDM34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7I8"/>
    <dbReference type="STRING" id="6205.A0A0R3X7I8"/>
    <dbReference type="WBParaSite" id="TTAC_0000951301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000951301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000951301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057570">
        <property type="entry name" value="NOL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25467">
        <property type="entry name" value="NOL9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="10">
        <location>
            <begin position="208"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="NOL9 C-terminal" evidence="11">
        <location>
            <begin position="422"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000951301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="566" mass="61356" checksum="D66E810816A3B7BD" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7Z6</accession>
    <name>A0A0R3X7Z6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS9656</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020962">
        <property type="protein sequence ID" value="VDM34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7Z6"/>
    <dbReference type="WBParaSite" id="TTAC_0000967101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000967101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000967101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000967101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12243" checksum="79DC0CC7076E7E9D" modified="2016-01-20" version="1">MHCPTSAILPPPANDCCSQHDETQIYEESIAWVWNLNLRSVVLSFVQKPGLPCASSMQVEHCPSSAITVGAEDRTLRAHTGWGSGEGGEKGKSSDTRREQDLNLRGESPMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X845</accession>
    <name>A0A0R3X845_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9705</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01020993">
        <property type="protein sequence ID" value="VDM34603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3X845"/>
    <dbReference type="WBParaSite" id="TTAC_0000972001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000972001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000972001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="468"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000972001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="685" mass="77081" checksum="555194113979BCB7" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8J3</accession>
    <name>A0A0R3X8J3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aa_trans domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS9853</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021111">
        <property type="protein sequence ID" value="VDM34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8J3"/>
    <dbReference type="STRING" id="6205.A0A0R3X8J3"/>
    <dbReference type="WBParaSite" id="TTAC_0000986801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000986801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000986801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278520at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="34"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000986801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29678" checksum="96273E92778849E6" modified="2016-01-20" version="1">MATYDSLSDGDHGIEVADDHQPQEQDHPELSVKNIGAVSALFNFLKGNIGTGILALPVAFKRSGLCLGFAFLIFYACLSTYLMHVLLRISNVVIIKNNLDRSKIDYAEAVFYVVKFGPERFRSYKGKAKHTINIFLLLTQIGFCCIYMLFVAQNTKYVSWNDETTWPEVRANLYLIGFIVAVLLVMLNIKMTMLIFAIPSAIALIATTLGLVLIFVYIFSTGLEDITSLPAFTSFSEVLVALGIFIFSFEGIALVRSSFNYRQSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8T8</accession>
    <name>A0A0R3X8T8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9948</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="UYWX01021185">
        <property type="protein sequence ID" value="VDM34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8T8"/>
    <dbReference type="STRING" id="6205.A0A0R3X8T8"/>
    <dbReference type="WBParaSite" id="TTAC_0000996301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000996301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000996301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF2">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133267" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="709"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000996301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116423" checksum="C5E43AE211B01A9B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8U4</accession>
    <name>A0A0R3X8U4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS9954</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021189">
        <property type="protein sequence ID" value="VDM34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8U4"/>
    <dbReference type="STRING" id="6205.A0A0R3X8U4"/>
    <dbReference type="WBParaSite" id="TTAC_0000996901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000996901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000996901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF394">
        <property type="entry name" value="APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="295"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000996901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64031" checksum="764FA75ABBB03FF4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X8Y6</accession>
    <name>A0A0R3X8Y6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS9996</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="UYWX01021224">
        <property type="protein sequence ID" value="VDM34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X8Y6"/>
    <dbReference type="STRING" id="6205.A0A0R3X8Y6"/>
    <dbReference type="WBParaSite" id="TTAC_0001001101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001001101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001001101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000109">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001001101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44185" checksum="1B4F777B9AF75BB5" modified="2016-01-20" version="1">RNFDFVEFFTPVSTASRLPALPSLREIIRIYNLRAQKQLSQNFLLQPSSINSLVGCAGSLLDACVLEVGPGPGGLTRAILRQRPRHLVVVELDRRFIPLLEELRLSACEMGVKMDIYRGDILKVNTGDIFSVTSIHQSETWGSAVNNVISKLNGVSTAVVEAGMERPPRVRIIGNLPFSTSTALLISWLDNIANHRQIWRLGRVPMTLTFQKEVCERLVADVWDEQRSRLSVMAQAFCEVQFLKVIPGSAFVPQPKVDAGVVRLIPLSQPLISAPFPYVEKLVRHAFQFRQKLIVRCLESLFPPERPDLVIRLFKEAAVQPMKRPIQLSNLEFRDLCEVYARICASNEGVFGYEFRKPENLPHWHSRKDTQRRILGSAITAEVVRKEMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X975</accession>
    <name>A0A0R3X975_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MHD2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10085</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021297">
        <property type="protein sequence ID" value="VDM35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X975"/>
    <dbReference type="STRING" id="6205.A0A0R3X975"/>
    <dbReference type="WBParaSite" id="TTAC_0001010001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001010001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001010001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD2" evidence="2">
        <location>
            <begin position="479"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001010001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="697" mass="78470" checksum="923526ECCBAF5A15" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9B1</accession>
    <name>A0A0R3X9B1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10121</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021330">
        <property type="protein sequence ID" value="VDM35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9B1"/>
    <dbReference type="WBParaSite" id="TTAC_0001013601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001013601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001013601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133242" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001013601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10139" checksum="12AA5947C2D613BD" modified="2016-01-20" version="1">MQSASTLICLCLLLPSPSSLSHRILSLPPQRLWRMRKRGGGRRESAEVGDVSDAEESDDVVADVFEMQSLGVSNEAEENEYVLIPAKPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9H2</accession>
    <name>A0A0R3X9H2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TdIF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10182</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021397">
        <property type="protein sequence ID" value="VDM35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9H2"/>
    <dbReference type="STRING" id="6205.A0A0R3X9H2"/>
    <dbReference type="WBParaSite" id="TTAC_0001019701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001019701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001019701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860246at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TdIF1 C-terminal" evidence="1">
        <location>
            <begin position="206"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001019701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="310" mass="32791" checksum="9C765DB9CE81E1C0" modified="2016-01-20" version="1">MDATAQYQVPSVESPCPEAAVTPTIAAPCAPAEYPSPIAVTASNPAADLRRSVLLRSSTRHLRRRTLSSCGGSSLARSPSPLSDNVGLMLLPDTGASPFPLPSLGEEGDGCVAVGDRSTPAKRRRRYGGKVDSLQVGFLDNAISLNGSITDGDPSVVDVLGPLELELPDNASRGQGSSTASEAASNATAHSFHLDGHLPPHLLANDSFALGSCANAWLGLGAARGRIYSKHPWIFRYACDREDKSWLSRAGHLPNCGAKAFLVLAKQIYEVASMDNSLSTAATTRGPLPQFVLPPWLFRKVRLLLALCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X9P3</accession>
    <name>A0A0R3X9P3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10253</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021478">
        <property type="protein sequence ID" value="VDM35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X9P3"/>
    <dbReference type="WBParaSite" id="TTAC_0001026801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001026801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001026801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001026801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13157" checksum="4C9862FE17B869E9" modified="2016-01-20" version="1">MRIRRNKAVLTTNKAIDYYKEALEVEVNGRHIGESGGVRRRSMCNGLMWEEEEEEEMVEEEEEEEEQSVGLDEPKPGTSPLITFSFSSSIHFKQTRLSFLGLASGQHVRDAPKGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA84</accession>
    <name>A0A0R3XA84_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021708">
        <property type="protein sequence ID" value="VDM35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA84"/>
    <dbReference type="STRING" id="6205.A0A0R3XA84"/>
    <dbReference type="WBParaSite" id="TTAC_0001046101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001046101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001046101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001046101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64667" checksum="985ABA7B3DDC33F4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA99</accession>
    <name>A0A0R3XA99_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyltranfer_dom domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS10460</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021724">
        <property type="protein sequence ID" value="VDM35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA99"/>
    <dbReference type="STRING" id="6205.A0A0R3XA99"/>
    <dbReference type="WBParaSite" id="TTAC_0001047601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001047601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001047601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF78">
        <property type="entry name" value="EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001047601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="595" mass="66444" checksum="7592AA740FDEF423" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XAE7</accession>
    <name>A0A0R3XAE7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS10507</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021782">
        <property type="protein sequence ID" value="VDM35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XAE7"/>
    <dbReference type="STRING" id="6205.A0A0R3XAE7"/>
    <dbReference type="WBParaSite" id="TTAC_0001052401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001052401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001052401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000255">
        <property type="entry name" value="serine/threonine-protein kinase Chk2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="108"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001052401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52063" checksum="B163AF10D3DD99DF" modified="2016-01-20" version="1">MAVMSDLPPTQEVGDLSTQDINSQPVSQIWGGLFPLKRKIPHLAMSKESYTVGREGSCDIVLTPEMFTTGPFLSAVSKVHFRIARFVQGFLFTDRLSSDYPEEVSSKYTICRSLGRGACGEVRVAYARETCIQYAMKIVPKRTLSSHGSRFGNRELTEVEILKKLNHPCIVKIHDVIETEDTLFIVLELVEGGELFDRILNSGHLSEDDSKFFFLQILMATKYLHDNGITHRDLKPENILLTGKSNRCLIKITDFGLSKIVNDNTMLRTFCGTPTYLAPEVLLTAGNGTYTSSIDVWSLGVILYVCLVGYPPFTDERKDYDLKTQITNGLYDFPDVYWKGVSESAKDLVRRLMCVNPTERITLEEALLHPWLADQTIRDQLADLMKTAGFLDLVDGVLDAHNLVSCVRRDRSSTPVKLDENDKGADEGESNDTVSTLRNSSASRKRSIEAMTDEGCQSQLKKSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBB4</accession>
    <name>A0A0R3XBB4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COPIIcoated_ERV domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS10824</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022309">
        <property type="protein sequence ID" value="VDM35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBB4"/>
    <dbReference type="STRING" id="6205.A0A0R3XBB4"/>
    <dbReference type="WBParaSite" id="TTAC_0001084101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001084101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001084101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001084101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10737" checksum="A208CE1A58BABB0C" modified="2016-01-20" version="1">MARSINHNNQSHGVPGVFFRYDVFPVRVEVDVSGGDGASIVRLLVRLSAIIGGVFATGGFLCLLLRAITSFYYMMKTYLMPATLTPGLSASAPLIPDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBF3</accession>
    <name>A0A0R3XBF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-tubulin complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022392">
        <property type="protein sequence ID" value="VDM35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBF3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBF3"/>
    <dbReference type="WBParaSite" id="TTAC_0001088001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001088001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001088001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6256226at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001088001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11063" checksum="69272BBE882F3F0F" modified="2016-01-20" version="1">MQVKEQHMQRCVSFLTDELKVCGHEEAMERVFFVSAREVLTIRAKSLNGGTPPGSAPNIGSPSTGGMSFLHQLLGRIDRLCISLLRVCSFQPFLAITRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBJ7</accession>
    <name>A0A0R3XBJ7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyco_hydro_38N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10907</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022484">
        <property type="protein sequence ID" value="VDM35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBJ7"/>
    <dbReference type="STRING" id="6205.A0A0R3XBJ7"/>
    <dbReference type="WBParaSite" id="TTAC_0001092401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001092401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001092401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001092401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17500" checksum="2C01C62A139C8690" modified="2016-01-20" version="1">MFIRGPLRRFVVVFTVFFVVVLLIYFYATRGFIDMEILQEKVQQFNDDIAEKLKWSGGAFGFMKQKELKCEPQVVASFADIEPGTLYDSIPFKNEDGGVWKQGFNISYSLSDWDKQKLEVIVLPHSHQDTGSFWTMTFSVFSGILWLKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBQ3</accession>
    <name>A0A0R3XBQ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS10964</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022615">
        <property type="protein sequence ID" value="VDM35944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBQ3"/>
    <dbReference type="STRING" id="6205.A0A0R3XBQ3"/>
    <dbReference type="WBParaSite" id="TTAC_0001098001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001098001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001098001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001098001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7751" checksum="CA25CA6DCC9A6D87" modified="2016-01-20" version="1">MATKLSSCHYVCVNPALSTSLQSAATVSRIFHPNLLEMACDSVIGLLAMPQSVRFEPFAKACIVENVFDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC38</accession>
    <name>A0A0R3XC38_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022956">
        <property type="protein sequence ID" value="VDM36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC38"/>
    <dbReference type="WBParaSite" id="TTAC_0001111501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001111501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001111501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001111501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23145" checksum="03FB67459C111063" modified="2016-01-20" version="1">MSFERQASLYIGGGGSKGLTGTNQEENMNANCADRMKEFMKLIFLPPSCCYDLLEVCLISGLDDDHRGAHTALARWSDFQVMLQVVIVFSFGAVPFPTYEGVVVENEREFGSMSSLVATVCDKIGGVMEVCSATRDGRTSSAFTISMFLCHAIHLGNDRTCKSPANASSRCLPHSNIHARRREKRLQFLLHSHGSVLQPSGTSRSFERDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC52</accession>
    <name>A0A0R3XC52_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS11112</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022989">
        <property type="protein sequence ID" value="VDM36092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC52"/>
    <dbReference type="STRING" id="6205.A0A0R3XC52"/>
    <dbReference type="WBParaSite" id="TTAC_0001112901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001112901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001112901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM36092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001112901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23884" checksum="93CE92BEAFFA0AB0" modified="2016-01-20" version="1">MHDDPLRKFLNNFEELDPRAFYCDLRPYLSGWSHGKISKGLVYEGVPDSVLTGAEAGDLSGETIPKKRVYMGASAGQSVSLQSFDALLGIEHFKDVETFFADLRKYMILEHRRFIEDLRKYVHLRDFVTKSASKELKMAYNSCVNELLCFRKDHLQIVDKFIIEPSKLYTAKIEGLKSQGTGGTGRLQIEFHDTSSFLSIYHDVDGSPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCG2</accession>
    <name>A0A0R3XCG2_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lysine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS11222</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01023255">
        <property type="protein sequence ID" value="VDM36202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCG2"/>
    <dbReference type="STRING" id="6205.A0A0R3XCG2"/>
    <dbReference type="WBParaSite" id="TTAC_0001123901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001123901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001123901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="10"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM36202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001123901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36984" checksum="50425F31E09A2B91" modified="2016-01-20" version="1">MMSILPGGAAAKPFITHHNELDLDLYLRVSPELFLKMLVVGGMPRVYEIGKLFRNEGIDLTHNPEFTSCEFYMAFADYNDLITITEDLISGMVMKLFGTYKLTYQPEPDMPPQEVDFTPPFKRIDLYDALKEHYTGVEFPPPETLHTEEARHKLVAIAAKFGVQCSEPQTSARLLDKLVGERIEPLCINPTFIMNHPEVMSPLAKWHRSRPGLTERFEMFCLTKELINAYTELNDPVVQRERFEEQAKDKAAGDDEAMFVDENFVNALTYGLAPTAGWGFGIDRFMMFMSNTNNIREVIIFPTMRPEENSTSCEASVDAKTSVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XCP8</accession>
    <name>A0A0R3XCP8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD:protein FMN transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01023577">
        <property type="protein sequence ID" value="VDM36288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XCP8"/>
    <dbReference type="STRING" id="6205.A0A0R3XCP8"/>
    <dbReference type="WBParaSite" id="TTAC_0001132501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001132501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001132501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1695393at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001132501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7507" checksum="50F733F06399E54D" modified="2016-01-20" version="1">MGTEAAMMTWVMPGLDRLRLDFVEAGEKGSAEELEQLSSDLRQRLANHNSPTGFDINVLSGWWAIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDB2</accession>
    <name>A0A0R3XDB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS11522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024647">
        <property type="protein sequence ID" value="VDM36830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDB2"/>
    <dbReference type="STRING" id="6205.A0A0R3XDB2"/>
    <dbReference type="WBParaSite" id="TTAC_0001153901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001153901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001153901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM36830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001153901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11999" checksum="A2250759CFB1826B" modified="2016-01-20" version="1">MMCSAAFTQATVASTKASPDLMQSLHWASAPLVLEGRSVEDEIVRQSHSDIATIVISYTIMVVYVSICLGNYRGLRTCLSLLLLAVVLAPQDDRKLATGQKKADAMRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RD72</accession>
    <name>A0A158RD72_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TTAC_LOCUS10</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 21 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="EMBL" id="UYWX01000001">
        <property type="protein sequence ID" value="VDM15565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RD72"/>
    <dbReference type="STRING" id="6205.A0A158RD72"/>
    <dbReference type="WBParaSite" id="TTAC_0000000901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000000901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000000901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.10">
        <property type="entry name" value="btk motif of tyrosine-protein kinase itk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="277"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="451"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VDM15565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000000901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="735" mass="82026" checksum="890DD2417064DBFB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDE4</accession>
    <name>A0A158RDE4_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TTAC_LOCUS481</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000043">
        <property type="protein sequence ID" value="VDM16509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A158RDE4"/>
    <dbReference type="WBParaSite" id="TTAC_0000048001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000048001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000048001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="240"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1300"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VDM16509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000048001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1364" mass="152378" checksum="CE5DE71D16F0AEA8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RE35</accession>
    <name>A0A158RE35_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6554</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020308">
        <property type="protein sequence ID" value="VDM30781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RE35"/>
    <dbReference type="STRING" id="6205.A0A158RE35"/>
    <dbReference type="WBParaSite" id="TTAC_0000656901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000656901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000656901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251248at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM30781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000656901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="635" mass="70154" checksum="18054D41B202738A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REG9</accession>
    <name>A0A158REG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS7272</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020358">
        <property type="protein sequence ID" value="VDM31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REG9"/>
    <dbReference type="STRING" id="6205.A0A158REG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000728701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000728701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000728701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="247"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000728701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="600" mass="66852" checksum="CDF956FEA8AB839D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REY9</accession>
    <name>A0A158REY9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8383</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020494">
        <property type="protein sequence ID" value="VDM32924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REY9"/>
    <dbReference type="STRING" id="6205.A0A158REY9"/>
    <dbReference type="WBParaSite" id="TTAC_0000839801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000839801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000839801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6285121at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM32924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000839801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133994" checksum="0D44A281DABCE56B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RFA0</accession>
    <name>A0A158RFA0_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS9282</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="UYWX01020747">
        <property type="protein sequence ID" value="VDM34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RFA0"/>
    <dbReference type="STRING" id="6205.A0A158RFA0"/>
    <dbReference type="WBParaSite" id="TTAC_0000929701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000929701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000929701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="518"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000929701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="765" mass="85357" checksum="2406ECBC72ACDEDB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EKP1</accession>
    <name>A0A3P7EKP1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Troponin T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000096">
        <property type="protein sequence ID" value="VDM16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EKP1"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31200" checksum="57D74771BD445444" modified="2019-02-13" version="1">MSFFALQEERTRKKREEEQRKREERERKRAEFAEKSKLTTRRNFVINKKAGSVEQVEEVKQEEVQKSKEQLEAERKAILEQRIQPLQIDGLKGEQLRAKAKELNDIILRLEGDKYDLEQRFSRQSYDASFLLCAIHSSTSFSTHPFIHLSIPSFMQELAERARQMNKGDKRGTKVQNTPDPLAAKISGLPPKISMYSEYERVKDHRSFSERQGVFSGPLFVERYERIEPKVHVVMTEDGFQVGDAPHHPPPPPVSETPAEPTEPVAVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7EVM1</accession>
    <name>A0A3P7EVM1_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS2514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001162">
        <property type="protein sequence ID" value="VDM20299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7EVM1"/>
    <dbReference type="OrthoDB" id="5964980at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="393"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM20299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="580" mass="63989" checksum="D742ACFBEB62D2BB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F2X8</accession>
    <name>A0A3P7F2X8_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KY-like immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002641">
        <property type="protein sequence ID" value="VDM22877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F2X8"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KY-like immunoglobulin-like" evidence="1">
        <location>
            <begin position="98"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM22877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="336" mass="37984" checksum="025BA44957B96263" modified="2019-02-13" version="1" fragment="single">MHCKLLLGYAKGADYSPGMRFSGAAAGQHSWNAVLVDGTWHLVDCHWAARRLIVKRASVENVRYILDTFYFLTNPSQLIYTHFPHDKDWQLLHHPITLEEFEALPLVKSAFFKYNLSLVSHRTAVILFSDPEVRVVIGYPKDANNTFLFTIGLSFDDSESSEHYNNISLMRYARQEVVARECCVAFYIRPPRPGAYKLLVYAKKRDGSGMDGIYREEEAPGISRAAGEKNLYGAVCEYRLMARTPSNACLPPFPPCQTGNYGVTEMFNRFNVVPIGPEANEATLRARNGVVEVRFALIGGSQRPMPRMMGRLRCSLLPEEDLDNCILYRVLKSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7F447</accession>
    <name>A0A3P7F447_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020297">
        <property type="protein sequence ID" value="VDM30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7F447"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="68"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="VDM30451.1"/>
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    </evidence>
    <sequence length="295" mass="34408" checksum="28E922802829E456" modified="2019-02-13" version="1">MIVLFIQSSWQSFPLLAIGRYLFEKSKFLQKFHLDYFLFVRLLRTYFSVFYIVLGQIEDLYHENNPYHNALHAADVTQATYCLLKRLRVEGFISAFDFMCALLAAICHDIDHPGVNQAFLIKTKQMLSIFYEESVLEHHHSNVCISVLLQSQCHLKRLILATDISKQEEYLDRLEVRLSFDIMAIKCADISNPCRHWEACLQWANCITEEFFQQGDRENLLALPVLPLMNRKKTTKAKVQIGFIQFQVLPLFEQWDAYVRSKFTRSLVAKCKKNLAVWLARDTVATGEQHANLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FAN5</accession>
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        <name type="scientific">Hydatigena taeniaeformis</name>
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        <name type="synonym">Taenia taeniaeformis</name>
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            <dbReference type="EMBL" id="VDM25729.1"/>
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            <dbReference type="Proteomes" id="UP000274429"/>
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</entry>
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    <sequence length="1095" mass="122156" checksum="7FCD3DF827BB45CB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FJ46</accession>
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        <recommendedName>
            <fullName evidence="8">Annexin</fullName>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the annexin family.</text>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0041">Annexin</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM36210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21168" checksum="DC7C56ADD85D751B" modified="2019-02-13" version="1">MEKDIVSETSGDFRRILVAMLQAQRDENPQVNQTQVEVDVDALYESGEGRVGTEESRFTQIFSQRSFPHIKEIAKTYANRYKKTIYEAIRSETSGNYCETLVTIVSYAEDQISLFVNWLQDSMAGLGTRDDDLIRLILSWAEVISTLDSVFPTYQRKTNKLLTNAIESETSGDYKRMLISIVEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7FS27</accession>
    <name>A0A3P7FS27_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS7290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020359">
        <property type="protein sequence ID" value="VDM31649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7FS27"/>
    <dbReference type="OrthoDB" id="6273279at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114173" checksum="EE2D0B170ECB56B9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HJ36</accession>
    <name>A0A3P7HJ36_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS9778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="UYWX01021045">
        <property type="protein sequence ID" value="VDM34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HJ36"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="510" mass="58558" checksum="ED8A0F4983C5B02C" modified="2019-02-13" version="1">MKLSKSKLVVYPSHSTDFEVHRNWLAITYSTNVSEWYNEATSQWTLDYPPLFAYFEWALAQLASKVDPKIVLLSAEPYSSLATVYFQRISVLLSECILFYSICSCLVSLTFFRAKDIHFQYNGFLFGILFLSILKAFQGSILWSGFWFSILLNLKHIFVYIAPVYFVFILFHYCLKREKGRFKAMLSRLFAIAGVVGIVFAVSLAPFIYWGKMANLLARLFPFKRGLCHSYWAPNFWAVYNTVDRTLTLPIKFCSRQPTGSWNNVVPMTSGLTGNYEHLCLPTIRPLHTAVLTAVFMIPSLVLCKYNNESMCPVDSGFLLLRSIVAASWACFLFGWHVHEKAVLMITLPLTFLAVASRRLRGIAFYVNTVAHFSLLPLIFTPNEQPIVLSSYLVYSLTQYLLLGRSSSPVTRGLLFTFWPQLTGLARVHLLGLIPLLLVNRVFLPLVYPHLEFLPLMLTSVYCAVGLLLAFLVYVWINFVWLRAEKETEMEDETENYFYQVNASFFKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P7HKP5</accession>
    <name>A0A3P7HKP5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS9927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021167">
        <property type="protein sequence ID" value="VDM34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P7HKP5"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="106"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <sequence length="473" mass="52183" checksum="A5B2DCFE0494A362" modified="2019-02-13" version="1">MSLQPVQEKPGTIQISWIDTYADFIRDHGPLVFILQTRFCVCKSFSEKKASKWQTVLMAVNTTTTVDTFDPGHIYQFRLAAVSTQGSRGFGPASRPYPLNALRPQPPRNVTATKWSIHPNGEVSVRLSWAPPEATGLPLIEYSVSWALDSGYPTTTSSKPLEDSGVPFMQSVQTKDSEITINSLRPGSSYKVQVTAIYFHDDGNLQSLPHNFFISTQSLLPLYRQRNMALENAKNIPPATGHVDNNGGGYDGGNRGDSETCRCSGLTKNDERLEIQPPEVFNGDLTALVQLKSFSLDMDTQSYRIEWFPQVCIDTIENALTLPPAVSSPTAVNAASGSPHSVDTDSEVITATVRSRIFRLTKLKFSCVYLVRLTPEKADDMRSRFDSPRQPEQYRLVNGAPSSAFSSSSDSAEDVVAGCFCTRSCHETKTAWGTKPIDCPAAEIADFPYKTVNYSKHQPLLEEDFAREEGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WHT4</accession>
    <name>A0A0R3WHT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4757 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS122</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000008">
        <property type="protein sequence ID" value="VDM15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WHT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WHT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000012101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000012101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000012101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000012101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15676" checksum="CE0B8D54FD9A1A83" modified="2016-01-20" version="1">MDGESWQTNLESWRERRRAAAKALALEIQQHCDASPQSRAVTKDHILYPNNDTQDNMQKLKTPDRDILKMGPQCASQCDVCSGIGNFVSSAPSLPSDRKQSFSFHTEPKQASPPSRPDVKTVQSDDMVILHQAAIVVEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WI75</accession>
    <name>A0A0R3WI75_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS285</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000020">
        <property type="protein sequence ID" value="VDM16194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WI75"/>
    <dbReference type="STRING" id="6205.A0A0R3WI75"/>
    <dbReference type="WBParaSite" id="TTAC_0000028401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000028401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000028401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000028401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50233" checksum="2736F5560653488D" modified="2016-01-20" version="1">MEGKSLSKNLTEENNELKQYIDSLNKECMELQAALFEEANKMAQNAYAAEHAAVKRTKEVERENLILKKEVQSLKNSLRLQVEEKRDVVAVRRSMSGVVSQANALEAEDKGKGNRLRRLSILLNPSPNLPQSSACLAAPVDRRRWSSTLSTSIINVTSQEPVTRKYLLEALTSGVNCAETFCPVVGRTSVLTFSLLMLERNPIEFVDWVDCGCCLNWPVNSDGSGGETNQQPMMSITFADSTSNGEDFRTRSASDVGDIRLPHPAPPPPPLPSSKEQAFFHRLVREDIAPALAFADSHICAALPLALSRLGVEMEPLSSIFASSPTTDVDVTDIPTCPLVPGEPVKFSLKLEMVNEDDSISVECCNISSWARQRIAAVADLFQYLSLIRRGLTGTPTTPVTRSSSNSLPPVNRASLSLTVDSDAPTELIRRHQFENVQRRRLVIALSRLGYGLPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIF7</accession>
    <name>A0A0R3WIF7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS381</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000031">
        <property type="protein sequence ID" value="VDM16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIF7"/>
    <dbReference type="STRING" id="6205.A0A0R3WIF7"/>
    <dbReference type="WBParaSite" id="TTAC_0000038001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000038001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000038001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="8"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000038001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="458" mass="49617" checksum="4F8288B9462ABBAA" modified="2016-01-20" version="1">MKVRFSIWGILCVLGGFLYHLALGYFYTVGNMIPYVVSYMGIKSSEAAWFSSTLLALQAVFMPTGAILATKLGYRPVFIIAMVFSAGGILLTRLTIDYGLGPYIATYCILNGIGMGVPYSVIFSVASSWFPEHRATVVGIISSGFGLGALVFTPIQTAIINPNNLPVNGTKFPPSVEEGIPMAFIVLGGIVLGLELIGTILDDDETAISLTNSTAEVKKKTLNVPKSYTVSEALKSVDFYLLWLIAFCDIIPVYGIRSAFDDQFLSAIATTSAAFNCLGRVFWGHMVDRFSSKCPLMCFLVMWGSLFVTFPYVAVGAAGKTLYAIWVFGLFFALSAHFVIIPGTCTRVFGPANMATIYGLIYFASCPSSLITAGVISQFDILGKWIAVYTACACACLLSFTMALFIRDRDAHCVGFTNKFCAALCDPYRKTIYNASEQEEEGHEEERGEGEEAGGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WIU4</accession>
    <name>A0A0R3WIU4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5726 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS546</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000053">
        <property type="protein sequence ID" value="VDM16623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WIU4"/>
    <dbReference type="STRING" id="6205.A0A0R3WIU4"/>
    <dbReference type="WBParaSite" id="TTAC_0000054501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000054501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000054501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6229818at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM16623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000054501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49535" checksum="74F3457415E2ED5C" modified="2016-01-20" version="1">MAACRNQPLLAPDYARVSNRFHRVVSNWSLPDLDKVIWALERDNMLSVEELSRIVPSKKIEEIEQLISLCLSSEEADFGGNLEPQRISTEESTLEIIKNSVKSVVPGQFSPGPGISSVLRDIAKKERFNNMDNVCGAKRLGGHKGFILPDYGRIYEYIADLLTLAKTRPHIGDSDMVVLLDMLFCLLQATDYLLRKGSAGDIEQAFSVVRDKIGVLISSISASYQHRCAFLKQISVSSVYDIDSLTSCFPQAALTSAPCRPNVLPYMAPILVVKEARLSYNVSQCALLKRTMRDVFRQYWQPPVMKEDEDLQIVHKKLAKFILNPLCLNEKLVPSVCEYLSTLSMLMRHYEERITSLTSITTTESHSFCKQNVLIQSAAKLIADYRSGKKNFVRRISLPVERHEIDKFINAVSFSFPLAMFKAKKASSRQPKLYRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ11</accession>
    <name>A0A0R3WJ11_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS631</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01000069">
        <property type="protein sequence ID" value="VDM16767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ11"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ11"/>
    <dbReference type="WBParaSite" id="TTAC_0000063001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000063001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000063001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM16767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000063001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="551" mass="60946" checksum="D3ECB2829050399F" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJ15</accession>
    <name>A0A0R3WJ15_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TTAC_LOCUS638</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000070">
        <property type="protein sequence ID" value="VDM16776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJ15"/>
    <dbReference type="STRING" id="6205.A0A0R3WJ15"/>
    <dbReference type="WBParaSite" id="TTAC_0000063701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000063701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000063701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VDM16776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000063701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="935" mass="105828" checksum="76F386F68E71D98A" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJB2</accession>
    <name>A0A0R3WJB2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD_REPEATS_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS752</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000089">
        <property type="protein sequence ID" value="VDM16937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJB2"/>
    <dbReference type="STRING" id="6205.A0A0R3WJB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000075101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000075101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000075101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM16937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000075101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="855" mass="95399" checksum="A7ECE293897EDC62" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WJF6</accession>
    <name>A0A0R3WJF6_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TTAC_LOCUS805</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000101">
        <property type="protein sequence ID" value="VDM17016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WJF6"/>
    <dbReference type="STRING" id="6205.A0A0R3WJF6"/>
    <dbReference type="WBParaSite" id="TTAC_0000080401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000080401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000080401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132877" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VDM17016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000080401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34805" checksum="33A7BEC09E3EA70E" modified="2016-01-20" version="1">MFLGFLPFACLIGVVFSKPQDPTLRAHDRKLNDPLVGLDELTSGHSPSTTRKEGEKLLAQLVDKMDLDNDGFISEDEMRMWLKSVASKYVDQDVSRTFDEYRNEFKTDYVTFEQHKNKTSDDYEEDGESDDGELQQTLVRDKRRFEKADADGDGKLTKEEFAAFLHPEEFEHMRDIVIAETLEDLDSNKDGLIDLEEYTRDMWVDDSQSPPEWVRTEQQQFREARDKNKDGFLDREEVYAWLFPADYDHIESELKHLMSETDDDQDGKLSKDEILSHYHVFVGSQATDFGQALYSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKE7</accession>
    <name>A0A0R3WKE7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-RVT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS1186</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000207">
        <property type="protein sequence ID" value="VDM17594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKE7"/>
    <dbReference type="WBParaSite" id="TTAC_0000118501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000118501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000118501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM17594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000118501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13836" checksum="B5B7664EB74DFFF7" modified="2016-01-20" version="1">MLEGGGEMGTREMAGTIRCDVCGCILRNLNFQITKPYSIIAERLTTALRWESPQQLNAIVLTYLLTYFPLSRRFYVPSSQVLSVGPDERKQVRIEKWLTFCRIDSQALLHVLEDDTILKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WKX7</accession>
    <name>A0A0R3WKX7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TTAC_LOCUS1387</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000290">
        <property type="protein sequence ID" value="VDM17907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WKX7"/>
    <dbReference type="STRING" id="6205.A0A0R3WKX7"/>
    <dbReference type="WBParaSite" id="TTAC_0000140001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000140001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000140001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9986177at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11722">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132855" evidence="13">
        <location>
            <begin position="22"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VDM17907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000140001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="659" mass="72989" checksum="32A91994F00F925C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLL1</accession>
    <name>A0A0R3WLL1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS1636</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000419">
        <property type="protein sequence ID" value="VDM18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLL1"/>
    <dbReference type="STRING" id="6205.A0A0R3WLL1"/>
    <dbReference type="WBParaSite" id="TTAC_0000164901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000164901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000164901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057825">
        <property type="entry name" value="WWE_SEC23-DDH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23464">
        <property type="entry name" value="WWE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC23-DDH2 WWE" evidence="2">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000164901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39428" checksum="3DDB739267611F0A" modified="2016-01-20" version="1">MCLTEPIRAANLMRNTARLAAPAVGFPAPGMYTSPNTNVPSSLHNVASNSRLTINFNPAELLSGPSLIPPPMASSTAISGDQLPKKDQENLHVNTTSDIVPPPPIQLQSLIASANRPAGQLRSRYVLPPQLSQCSSPAPPLSTEDNLTESSTPTSQLESSFSTMTVLPTPTYFDCSSLTQTQEAKQSNDFTAPKVPYEPTKAHWFYSTKTVAHGIIWWPFDIADSQRLEAAATSANLLYVDALSVEAPNTAVPVRGGLYDVLLRERIYKPVYWPADEEEAGEVRRVMWLYRPQNEQRVLPFSETLSKTLEEHYRRALETNIWGGRFSLPSEDVPNETDTYIFHNEKVWEMINREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WLV2</accession>
    <name>A0A0R3WLV2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1727</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000473">
        <property type="protein sequence ID" value="VDM18453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WLV2"/>
    <dbReference type="STRING" id="6205.A0A0R3WLV2"/>
    <dbReference type="WBParaSite" id="TTAC_0000174001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000174001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000174001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20803">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000174001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16894" checksum="89DC67B456CAA02E" modified="2016-01-20" version="1">MDEPFLSKPTETITSLEVESTADTDTQSSSPRGGTAVKGWFQGHAFIKKNLHKPATCHHCCDLLWGILGTTGMICEICNFLAHEKCIRQVVSPCTCIIPFLIQDPMAHCWSDVGHFKRKFCNVCRKRLDDLLSVRCESKCHSSLLFYVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WM88</accession>
    <name>A0A0R3WM88_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Receptor protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS1863</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01000562">
        <property type="protein sequence ID" value="VDM18603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WM88"/>
    <dbReference type="WBParaSite" id="TTAC_0000187601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000187601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000187601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043132888" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="654"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="768"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="969"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM18603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000187601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1441" mass="161707" checksum="904822D564C445A9" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WME2</accession>
    <name>A0A0R3WME2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS1917</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000604">
        <property type="protein sequence ID" value="VDM18657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WME2"/>
    <dbReference type="STRING" id="6205.A0A0R3WME2"/>
    <dbReference type="WBParaSite" id="TTAC_0000193001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000193001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000193001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
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    <dbReference type="PANTHER" id="PTHR48051">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="202"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM18657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000193001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32215" checksum="86ED0AEF1D248584" modified="2016-01-20" version="1">MCSVQCKYHGDAGLTKAREILSRQHLVVTRGIERVRSFPDWVSGVLVVQSCWGLAIRSVFFLLLPFCVRVATTKRTGMRDCAKKISRCRDEGKGHLNLSNSQLHALPTSIRDLGAHLCELFLYTNKLVSLPNEIGTLTQLTKLMVQENSLTSLPDSLAECTHLSILDVRHNKLCEIPPVIYRLPNLVLLLLRCNRIRVVDCEIGRLTKLQVLSLRENKIRQLPSIPGICELKQLTTLDVSKNQLEHLPEEIGQCRNLTEISLQNNELTSLPESIGELALLERLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WN57</accession>
    <name>A0A0R3WN57_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2182</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01000830">
        <property type="protein sequence ID" value="VDM19155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WN57"/>
    <dbReference type="WBParaSite" id="TTAC_0000219501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000219501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000219501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM19155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000219501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17710" checksum="AE0A95C1F78F7B6B" modified="2016-01-20" version="1">MVEEEKEEEEEEEEVKTMLTSEWTDYFCKEEEEEEEEEEEMEEQEEQEEQEEQEEEEEQEQEEEEQEEEEQEEQEEEDEEEEEGIGTLSRPPPYASQSRQGELRKEAQFNPLKVTMLPSTIVSATSVNWQQKALLLDLSDTTDMLTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WP56</accession>
    <name>A0A0R3WP56_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2531</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001178">
        <property type="protein sequence ID" value="VDM20374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WP56"/>
    <dbReference type="WBParaSite" id="TTAC_0000254401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000254401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000254401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000254401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10350" checksum="861300BC23FA6B53" modified="2016-01-20" version="1">MEVGDEASGGGQRDMQEGGFVSALLTRHANALLHAFRNGTESACASRLADFSPMVVAASFASPIASCITLCFSKANFATTVGLACVAELVVVVMVVVVALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPC5</accession>
    <name>A0A0R3WPC5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2600</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001268">
        <property type="protein sequence ID" value="VDM20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPC5"/>
    <dbReference type="STRING" id="6205.A0A0R3WPC5"/>
    <dbReference type="WBParaSite" id="TTAC_0000261501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000261501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000261501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000261501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24366" checksum="CD1F9E07BB074FEB" modified="2016-01-20" version="1">MQVQREAFNLGQLAHRNVVEFFGLWETQETVSHLPALVMEFAHGGALHTVVRRRPPVRPLSLADWALQIAEGMRYLHECAGLVHRDLKTANILIREPLVASPGPDDLINKTLIISDFGMSCPTDTIDSWVSGVGTAAYAAPEVICMEIFSLASDVWSYGVVLWEIFTMLEPFKEFDRAQQLVNIGRYRQKLFIPRPEAGFPEVIGAILTCKLLPPCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WPN1</accession>
    <name>A0A0R3WPN1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS2706</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001409">
        <property type="protein sequence ID" value="VDM20944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WPN1"/>
    <dbReference type="STRING" id="6205.A0A0R3WPN1"/>
    <dbReference type="WBParaSite" id="TTAC_0000272101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000272101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000272101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10563258at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM20944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000272101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40119" checksum="E257F7B6EE0E8284" modified="2016-01-20" version="1">MEPQTVYYSGTPMTPPQGVHIVKAGSQFVQPSGSGATQPVYYASGSQAQYHPQQVSNASTTTSSMTYNPQQPQQNFYTVQPTQYTSSAVPNSPQVYTVGASYQQQQATPQYQSLSQGQPQSPQLFYSPSQQSSSRLVYASSAQAQTPATQYQPQSSQIQYQSSPGQAQYYPPQSASTTRMVQYTPQTSYQVQSVQAYSSPPQQQIHVASRQVLQPQVQTATYQPQQTMYQPTQVSSTPVQAQVMRVSQPSSQQQIQVQQQIQPQQRQYVQNAGKPIDRAAYPMGAEANQQLTGYQPMGRAAPVGVATPPQQQQLQQYQPSQQRSHLQLAAAQQPRSVPQSPSQRPPTSPSGATPKLRQLVRLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQ55</accession>
    <name>A0A0R3WQ55_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TTAC_LOCUS2880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="UYWX01001629">
        <property type="protein sequence ID" value="VDM21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQ55"/>
    <dbReference type="STRING" id="6205.A0A0R3WQ55"/>
    <dbReference type="WBParaSite" id="TTAC_0000289501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000289501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000289501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054419">
        <property type="entry name" value="NSF_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21964">
        <property type="entry name" value="NSF_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NSF AAA+ ATPase lid" evidence="5">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VDM21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000289501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17133" checksum="6E9E9BC84539BE64" modified="2016-01-20" version="1">MSVVIVDNIEGLIEYNPVGPRFSNYMVQALKDLVSQPLPAGRKMLVLATTSMREAMEEQQLTRAFAWHLHVGMMSTPEHILSALEEDQRFTPQECRVIEQSLVQRKQTDPSFNLCVGIKHLIDLIDLVTQMEPDHRVSEFLSKLEDDNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQN4</accession>
    <name>A0A0R3WQN4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS3059</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001864">
        <property type="protein sequence ID" value="VDM21860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQN4"/>
    <dbReference type="STRING" id="6205.A0A0R3WQN4"/>
    <dbReference type="WBParaSite" id="TTAC_0000307401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000307401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000307401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM21860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000307401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22881" checksum="B39E703F00C989C2" modified="2016-01-20" version="1">MLLVCVVKILSAFIDNGYPPPVKKRVRQPKVGKQGTSLPEVSRLDMRVGKIVEVEQHPDADLLYVEKVDLGEDNLRTVVCGLARHMSSEEMRGLVGVFLCNLKPVKMRGIESQGMLMCATDASGRVEPLIIQSPTEITLGDRVYVHGYPSEPDSQSHLKQKVWDKVKSDMRVDGAHMATYKGELWRLKNTPDAVVKAPTVMDAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQS5</accession>
    <name>A0A0R3WQS5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS3100</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01001928">
        <property type="protein sequence ID" value="VDM21952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQS5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQS5"/>
    <dbReference type="WBParaSite" id="TTAC_0000311501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000311501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000311501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260408at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM21952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000311501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62395" checksum="BB204161436D35DE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WQX5</accession>
    <name>A0A0R3WQX5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH_38 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01001986">
        <property type="protein sequence ID" value="VDM22053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WQX5"/>
    <dbReference type="STRING" id="6205.A0A0R3WQX5"/>
    <dbReference type="WBParaSite" id="TTAC_0000316501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000316501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000316501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM22053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000316501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9171" checksum="B8564AA52249BE8A" modified="2016-01-20" version="1">MVKKKMLEPGFQDQTRELLLLHHSTLYTRQKRRAKSGQQLHIIRSLAEIGKRHSAKDVNKCEFVQPLFVSSSLIRREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WRZ6</accession>
    <name>A0A0R3WRZ6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS3521</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01002576">
        <property type="protein sequence ID" value="VDM22798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WRZ6"/>
    <dbReference type="STRING" id="6205.A0A0R3WRZ6"/>
    <dbReference type="WBParaSite" id="TTAC_0000353601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000353601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000353601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252026at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM22798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000353601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28229" checksum="BA00983A86002AFF" modified="2016-01-20" version="1">MECRNTLTEIKVLKAQPKQMLVICRDNGTPSRSASADVHLALLDVNDCIPLFSQSAYNFTVVEDYSTAFQGQRLVGSIRATDCDGPEFNHVVYLLLNSYHLFSIDSEGRIFTTRSLDREQEPVYELQVVATDGPIGNANSDERAYNSEALLLSTPYNSVTATVSVIVQDLNDNPPHFVHPANTSIPIRVSFQEDVGFVLTRMVAIDPDNGNNGTISYRVIRGNRHGIFKLGEHSGDLYIGKKMIPEQVVSQSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS20</accession>
    <name>A0A0R3WS20_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rap-1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS3545</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002617">
        <property type="protein sequence ID" value="VDM22842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS20"/>
    <dbReference type="STRING" id="6205.A0A0R3WS20"/>
    <dbReference type="WBParaSite" id="TTAC_0000356001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000356001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000356001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001686">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM22842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000356001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22387" checksum="F6DBE4406B7D4CAB" modified="2016-01-20" version="1">MTNLEYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKKVESLSEVLFLQEQFTAMRDLYMKNGQGFVLTYSITSPPSLFDLFDLREHIIRVKDTENVPIVLVGNKCDLEDERAVGKEEGQKLARRWNCSFMETSAKSKINVSEVCSLPSFLCTSFLLQEYSLISQYGLISEVNVITFLLIHVLWILTLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WS53</accession>
    <name>A0A0R3WS53_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS3578</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01002668">
        <property type="protein sequence ID" value="VDM22909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WS53"/>
    <dbReference type="STRING" id="6205.A0A0R3WS53"/>
    <dbReference type="WBParaSite" id="TTAC_0000359301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000359301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000359301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM22909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000359301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18002" checksum="A95075A10CF10F95" modified="2016-01-20" version="1">MHCWHTRQCADLSEQETLCIACDKHRDKIRESERSNVIVSAKLFLFTDDHYSIRQAVNKTLDRLGLEDLETLIISLSSELSRGALVDHPPCMGLPWARIPQNTAHSLLKIWPVLEEFVEANKIFRLGVCDMPVTDLEVLCAAVKVRSYFILLLRAVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSD1</accession>
    <name>A0A0R3WSD1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS3656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002812">
        <property type="protein sequence ID" value="VDM23080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSD1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSD1"/>
    <dbReference type="WBParaSite" id="TTAC_0000367101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000367101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000367101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM23080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000367101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14745" checksum="7D9E5037861C0322" modified="2016-01-20" version="1">MESYLETGELHANSMFAVLCPNLKSMQSVIQAEGERKASRALREASLMLNDKPVALQLRYLQTLSGIAAEHHSTIIFPLPIDLTTSFLMSNPAQSMKGGVGVHPGVNGTHTTAVATATTSTATTATTVSSGNNNSSDLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WSF1</accession>
    <name>A0A0R3WSF1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotran_5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS3677</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01002855">
        <property type="protein sequence ID" value="VDM23136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WSF1"/>
    <dbReference type="STRING" id="6205.A0A0R3WSF1"/>
    <dbReference type="WBParaSite" id="TTAC_0000369101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000369101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000369101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="6"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM23136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000369101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55683" checksum="F29CF215C8B3E1F0" modified="2016-01-20" version="1">MTSVTSLQTTMYRHEAKDIVRNAVRASDYDAVFFVGSGCTGAVHKLIHNLHLEKPPIVITGPFEHHSNMLPWRHLAAKVIRLNTDKCGNVSVHHLEEVLSTERMRANELGCSLIVCLAAASNVTGILVDVDKFSAVVHRHGGLVFWDYATAAPYVKIDMNPVVSGPNHGLVYKDAVYFSMHKFVGGVQTPGVLIAKKVLFKAGEKHPDGCGGGSVCFVRRNHQVYLKDVEEREEGGTPAIVESIRAGLVMQLKEAVTSEVIVSREAAIVKRAWMRFKSSPNLLVLGGDEAPRLPIFSVVVRHVFPDISTSGGQQELTPCERPMFLHHTFVAALLNDLFGVQCRAGCVCAGPYAMDLLGIDETLAKLYEDALVTSEVPVCRVQKTFDNVSREVLRPGFTRFSIPYFMSDEEANFVLEAVCFVADYGWAFLPLYSYDAMTGEWKHRQYDQLEDRQWLGHIKYTKEGMVWRRAKVKARSALPGGLQVRLLRTVFALRNVFCCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTB1</accession>
    <name>A0A0R3WTB1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS3986</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01003420">
        <property type="protein sequence ID" value="VDM23921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTB1"/>
    <dbReference type="STRING" id="6205.A0A0R3WTB1"/>
    <dbReference type="WBParaSite" id="TTAC_0000400101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000400101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000400101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61124at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM23921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000400101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21694" checksum="5DF0E51991A0E32A" modified="2016-01-20" version="1">PPLLSYNKATLVKSTFTYLSILFQIENDEGNRVPEVLLVVFTAFASLLVVVHITALMISTCILPQLENCNILHFSYIEMAWIFSTALGMLLFLVVVVLACWVKFWNISKWSAGVCFLIVGPVVVVFILFAIFFYRTLISFKYQHASKMVDSLDRWMSELERGTYSPVQPHSTSLPTSPTVKRSQDVTFVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WTS4</accession>
    <name>A0A0R3WTS4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell cycle checkpoint protein RAD9B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS4148</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01003777">
        <property type="protein sequence ID" value="VDM24292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WTS4"/>
    <dbReference type="STRING" id="6205.A0A0R3WTS4"/>
    <dbReference type="WBParaSite" id="TTAC_0000416401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000416401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000416401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM24292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000416401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39297" checksum="5753EAEDEF07FEA7" modified="2016-01-20" version="1">MAAICVFILSKDEPRFSNDVGDIHEMKISLLLAELKKLFRYWVNLVMKYILNVIHMRCAHSQMDDSSLQFSLRCVNSTRSAFAAVHFSECFFENASKLTETSVRFKLSAKTCCKVFRQNIAWEKALQRCKMCLENDQNRLIVQFFQRHGIVKTYNLSIIECESLEAVYSISSSTCQIVMSSKVASEIMQNFRPSQTEVTMDLQEGECVFRNYVPDSDFTAVITHIPVAPTEFEAYQLGEECDLTFSQKDFRTALMFGESMNALFVINCSRPGKPLILTFADEKYYKAHFVLATLPLPYFTTRIPLNSINTSLHSRSKSNADVSATSLYVNLSLKSNFTFCESTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUS6</accession>
    <name>A0A0R3WUS6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS4501</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004616">
        <property type="protein sequence ID" value="VDM25076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUS6"/>
    <dbReference type="STRING" id="6205.A0A0R3WUS6"/>
    <dbReference type="WBParaSite" id="TTAC_0000451601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000451601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000451601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM25076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000451601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47365" checksum="3F534E92608C42DC" modified="2016-01-20" version="1">MEKMRKQLLFFQRLRQDLERARLLSELVRKRERVKLELVSNSRAQLESRIVPTFRMLRNLIEDLQAKDTRNFFEAPVSTDVAPDYYSVIRKPMDFETMRNKCIDHEYLQVSEVQNDFNLIVKNCCEYNGRDTVYYKAAVAMAEQCAPILKEALENERFDIFDWNGEDTSTPTVSLTESIKAPEGTGVNSGGLLIPIPLEENNRDNRTFEDKLELTKPATITRGRLKSRDPAETASVFEEPPSKKRCLRESTTTSVTQPQSHRLRRSWFPEPLTLVTESTTNEAPVVGGTMSTFLMPEMLSNQDSTTKTTVLRLPHSPDRARPAFTIYRSRLATKEEDEDDSDDDSEEETEDSEDTQDTLAAAAAAAATTSTNYATPRNTTNTSTGVADGGRLLRNRSIEKSDVNAIKSASVRVSSNFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUT4</accession>
    <name>A0A0R3WUT4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM32A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4507</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01004631">
        <property type="protein sequence ID" value="VDM25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUT4"/>
    <dbReference type="STRING" id="6205.A0A0R3WUT4"/>
    <dbReference type="WBParaSite" id="TTAC_0000452401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000452401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000452401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000452401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12512" checksum="8D656757E2A1593F" modified="2016-01-20" version="1">MSQYSNVIKGALKLKTEGRITKKSKKRALKSSEKRDPNKDMLEDRSEAKITKTAAEVEFEKKKEKRMMERILTKAEKSHKQRIMEFNEHLNSMSEHFDIPKVSWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WUT5</accession>
    <name>A0A0R3WUT5_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS4511</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01004635">
        <property type="protein sequence ID" value="VDM25088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WUT5"/>
    <dbReference type="WBParaSite" id="TTAC_0000452501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000452501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000452501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043133000" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM25088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000452501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12096" checksum="0474727F790A9C0F" modified="2016-01-20" version="1">MRPLSGLALLLAFATYCVERFEGGLLEVPNFPSNEDKAEAREVDEKKGEGEEEEEEEELSKEAHEVDRQRTLLLTAGWSRLRLRKPRKYPIPICPHGDRSPGPMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WVP8</accession>
    <name>A0A0R3WVP8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM133-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS4826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01005438">
        <property type="protein sequence ID" value="VDM25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WVP8"/>
    <dbReference type="STRING" id="6205.A0A0R3WVP8"/>
    <dbReference type="WBParaSite" id="TTAC_0000483801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000483801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000483801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM25725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000483801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="293" mass="31700" checksum="176FB250ECDCB779" modified="2016-01-20" version="1">MAAVIGRFAAAGAKSGGKFATKAVTKKGGKGLAKSVGKVGKKKGLKKLAGGKGGKLKKFAEGQLKGAVMSGIENNCGDEGRESGGKHSKKPIKIKSPDRSHKSPEKKSGALPKGGKSKIHSKAENYAKSKVRGRHDTDGEDDDDSECGGESGGSDRERSTSREKGKKRGRSSDSNSKSKKKIRGDKKDKKNHKHHSTKDESDRKSKKGKEKNKKERSGDKSTDSESEKTRKTEKRKDRKSGKKNAKRSSEDACPDTSDSEMEKSVKKHHKKGKIAREEDLEDSSDGCDTEYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WW33</accession>
    <name>A0A0R3WW33_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TTAC_LOCUS4958</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P2X receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01005769">
        <property type="protein sequence ID" value="VDM25951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WW33"/>
    <dbReference type="STRING" id="6205.A0A0R3WW33"/>
    <dbReference type="WBParaSite" id="TTAC_0000497301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000497301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000497301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="494673at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004931">
        <property type="term" value="F:extracellularly ATP-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.940">
        <property type="entry name" value="atp-gated p2x4 ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="entry name" value="atp-gated p2x4 ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001429">
        <property type="entry name" value="P2X_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059116">
        <property type="entry name" value="P2X_receptor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00863">
        <property type="entry name" value="P2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125">
        <property type="entry name" value="P2X PURINOCEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125:SF31">
        <property type="entry name" value="P2X RECEPTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00864">
        <property type="entry name" value="P2X_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01307">
        <property type="entry name" value="P2XRECEPTOR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VDM25951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000497301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42395" checksum="5819CE7FCDB91F52" modified="2016-01-20" version="1">MYYEKGYQAFDEAVSGVTAKLKGVAFSNLTNSNIGAMVWDAADYVVPPQQRSAFFVMTNLVATPGQTLGTCEESHDITGNGCKSDKDCEAGRMVMMGSGVQTGICVPSTRKANLSVCEIYGWCPTEYDGPPNGFTLTNAPNFTVMLKNSIEFPQYHVKRRNILGWMDKHFLSTCRYNPNNEKLKYCPIFRLADIMEYTEAENKQIWNKGGMVSIRIEWNCDLDYSEEQCLPKYIFRRLDDFDSPVGKGWNFRFSHHYIENKVRKRNLIKAYGIQFFITVYGKGGKFHLLTFSMNLGSGLALLGIATVLCDAIVLNVTKKREIYRNARLDLVAQVQKKQKKVKNLCIGRRPNGSRLLRCERGFPTISLTTWFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX45</accession>
    <name>A0A0R3WX45_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diphosphoinositol-pentakisphosphate 1-kinase</fullName>
            <ecNumber evidence="3">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS5320</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01007022">
        <property type="protein sequence ID" value="VDM26685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX45"/>
    <dbReference type="STRING" id="6205.A0A0R3WX45"/>
    <dbReference type="WBParaSite" id="TTAC_0000533501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000533501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000533501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM26685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000533501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36512" checksum="8143069AF55611DF" modified="2016-01-20" version="1">MQCKRWTFISDKSGTDDKSSASSATTNTSGNSNTEKGSGEVNAILEGGQSTSTGTASGNEPCILLVVKWGGELTAAGRQQAEQLGRAFRCIYPGGDGNYGKNPGLGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGFLALEGELPPILVQMVKSANTNGLLDNDNDCHQYQQMVKKRIKKVMSYKGVWGEEHRQALAPTGAKSLLNAMDYVGNPTEACTKLFGYVQRLANRVAMLTANLREREKMSLYHNESWDLLLRRWGKLVKDFRSPNGDYDVSKLPDIYDNIKYDIQHNPGILIESEMLDFFSLARALADIVVPQVRVIFHLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX58</accession>
    <name>A0A0R3WX58_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4439 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007086">
        <property type="protein sequence ID" value="VDM26735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX58"/>
    <dbReference type="STRING" id="6205.A0A0R3WX58"/>
    <dbReference type="WBParaSite" id="TTAC_0000534801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000534801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000534801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10645128at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000534801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12726" checksum="A9F6A1972F56FB4A" modified="2016-01-20" version="1">MAPPPDRPLPYAVAEELDNLAAVVRLASTSSASDAASLAFNRCLEYKKQYKQYPGFLWRFARATHLMLMTSTVVGQTAGLRSGGTDDANSADNHWIDAGLSIARSAVRQVEASKPVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX79</accession>
    <name>A0A0R3WX79_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5354</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007160">
        <property type="protein sequence ID" value="VDM26781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX79"/>
    <dbReference type="WBParaSite" id="TTAC_0000536901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000536901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000536901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269896at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000536901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20962" checksum="02B7A4E55E111B38" modified="2016-01-20" version="1">MMKENRSRMHQRSFSAQTCDTIFKPCEYISILTSTSATPVNKTPNYQQPGQAYLTTNTYPTPNGNIRVVERRTRLKQEEREPRSSSVPVYKFTRDKAEGEEVRDTIIPSMDDSPTSVLRGVAPWMAAEERAAVIKKDRRNRMKQNVHTIRDHMLSSWGQVNFDGKPPRHPSATHVYPSPELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WX86</accession>
    <name>A0A0R3WX86_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Usp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5359</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007181">
        <property type="protein sequence ID" value="VDM26792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WX86"/>
    <dbReference type="STRING" id="6205.A0A0R3WX86"/>
    <dbReference type="WBParaSite" id="TTAC_0000537601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000537601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000537601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000537601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19825" checksum="BF779312948AB2CE" modified="2016-01-20" version="1">MPGYRRILFAVDESQYCRRAFQWFLHFMWHSGAKSNGARKAEDEAGGEDAITLIHVISPDLNTPMEAEVPVSMVEVNGGRGSKGVPRVMEKAFTEGKAVCQAFLQLASEAGATCCNACITVESRSSIGKAILRSAQIRGADMIVMGSHGHKAIHRAVHLGSVSKYITRHSHIPVVVIPPEALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXF3</accession>
    <name>A0A0R3WXF3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4704 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007475">
        <property type="protein sequence ID" value="VDM26966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXF3"/>
    <dbReference type="STRING" id="6205.A0A0R3WXF3"/>
    <dbReference type="WBParaSite" id="TTAC_0000544301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000544301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000544301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM26966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000544301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9093" checksum="B5667A35CFDB7E9F" modified="2016-01-20" version="1">MSVWQDWVIGLASLFPQNRQNSYATATVMEILRCLLFYALRFEFGGWRVWIDTLAILHSRIAFEEFRRANQQVISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG4</accession>
    <name>A0A0R3WXG4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5439</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007518">
        <property type="protein sequence ID" value="VDM26998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG4"/>
    <dbReference type="WBParaSite" id="TTAC_0000545401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM26998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="96" mass="9772" checksum="DE0F4744C0E7EC4E" modified="2016-01-20" version="1">MHVLGVGGKSWQVDGRGKEPRLAPVQLRGRVGCSVRSVAWLVAGAVADCWCQYGYYTTWLPLPACLACLPAAATAGSPASCGCRGTGPPVVDAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXG9</accession>
    <name>A0A0R3WXG9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5442</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01007536">
        <property type="protein sequence ID" value="VDM27006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXG9"/>
    <dbReference type="STRING" id="6205.A0A0R3WXG9"/>
    <dbReference type="WBParaSite" id="TTAC_0000545901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000545901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000545901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10540260at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000545901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21284" checksum="7359A14C1543898A" modified="2016-01-20" version="1">MPISLQALTWEERERLLSKSQGLSRKFPSADPLPTLPRSGEETTSSVGDGGKNHKIGDCCSPIARIRSLEEIQAKSSGFLEKQMATLLVASRFCGKDEKVVIEVAAFDEDIHKSESEDVVSLSDWLFAMREHIEEQVKWGVEAFGHEVYIPEATSLTKHGTVICASTIPDIPAASLEALCSSTTKEVSEPPVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WXX9</accession>
    <name>A0A0R3WXX9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS5603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008175">
        <property type="protein sequence ID" value="VDM27306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WXX9"/>
    <dbReference type="WBParaSite" id="TTAC_0000561901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000561901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000561901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM27306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000561901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10447" checksum="4DA3C1702828D4F0" modified="2016-01-20" version="1">MNKSEEQPLSTAECILNKPSAALTFQLAMQLREYTRDNDSNLTQALKRLVQVHSPLLKRDHVLCSLSLSLSLVALGHAESNVEQVRRKETPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYB7</accession>
    <name>A0A0R3WYB7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Longin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01008830">
        <property type="protein sequence ID" value="VDM27572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYB7"/>
    <dbReference type="STRING" id="6205.A0A0R3WYB7"/>
    <dbReference type="WBParaSite" id="TTAC_0000575701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000575701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000575701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000575701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21725" checksum="7629F90B147E4282" modified="2016-01-20" version="1">MYQNSYQLRDESLSMMSFKILLNISGAYLIVTDPEKKKDLSSEPSVSTSSYKTSQEDAIVPENEGSKEETKKTPMIILYSLTKGNNNSCVLVMIDLSKEIADQTSAYRQFTRSAQHMRRTYSIARDFSSRLQPFLQARSNARRSILGSVSFEALSYRVPRPSINLQLSRLRREDKRDKKTKKEVFLCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYJ3</accession>
    <name>A0A0R3WYJ3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009189">
        <property type="protein sequence ID" value="VDM27725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYJ3"/>
    <dbReference type="STRING" id="6205.A0A0R3WYJ3"/>
    <dbReference type="WBParaSite" id="TTAC_0000583301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000583301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000583301"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10642305at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000583301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33612" checksum="92AE11F8926E34D2" modified="2016-01-20" version="1">MVEMICSQPDAEVAFNLASALGYASAFGREKVCRVLLRRGADPTVTGKDGLRPIDRVKAAKPLGGREVIELLEGYMSKKEESAYVPAQGSSSQLLPIYQNEESSSTEKQLFILATEIFPGLVDVFAQTQLESVKYQAVLILLQLVSRLSSQSLTIINTYPFGISLGFRLTQMIFMALAEESERTVHCVFQLCHQLLTKARSIYLPLMHRTGIIPLIKSIDSVMQLPHFRFLCENDYGNYYYPIREISNETDGQGSDDSSDSTVDFIPNENVGESDGTDSEYTEAADVATEGSHEGAEGEQQNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WYP1</accession>
    <name>A0A0R3WYP1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rootletin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS5867</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01009418">
        <property type="protein sequence ID" value="VDM27836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WYP1"/>
    <dbReference type="STRING" id="6205.A0A0R3WYP1"/>
    <dbReference type="WBParaSite" id="TTAC_0000588101-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000588101-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000588101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM27836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000588101-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11903" checksum="980725E7644F78EF" modified="2016-01-20" version="1">MISEKEVRVRELEQALRESVRLTAEREAHVASREDSTRQLEHQLRELRSTVEHLQRERNNLSSQLASLQEELHDRESQLKNLKSECVSFFTALSYLTFAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZ91</accession>
    <name>A0A0R3WZ91_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Programmed cell death protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6079</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020293">
        <property type="protein sequence ID" value="VDM30225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZ91"/>
    <dbReference type="STRING" id="6205.A0A0R3WZ91"/>
    <dbReference type="WBParaSite" id="TTAC_0000609401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000609401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000609401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF9">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM30225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000609401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20362" checksum="7E08985A3E75F7CE" modified="2016-01-20" version="1">MSQGFSRDRLYQIFQKLDKDGSGSLSAPELQKALSNGTWTPFNIITVQAMIDLFCPNNSMDINFDGFLRLWDFVEGWQRYFKAVDRDNSGCIDIHELQSAISQAGYRLSPGLYQLMMCRFDRKKKGVIYFDDFMYMCIILQKLTEQFRNLDTDRDGFIQIGFEDFLVRIFTVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZV4</accession>
    <name>A0A0R3WZV4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe_hyd_lg_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6341</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020300">
        <property type="protein sequence ID" value="VDM30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3WZV4"/>
    <dbReference type="STRING" id="6205.A0A0R3WZV4"/>
    <dbReference type="WBParaSite" id="TTAC_0000635601-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000635601-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000635601"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM30533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000635601-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="580" mass="64198" checksum="3EFBF168B58CAED4" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3WZY3</accession>
    <name>A0A0R3WZY3_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS6377</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020301">
        <property type="protein sequence ID" value="VDM30578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3WZY3"/>
    <dbReference type="WBParaSite" id="TTAC_0000639201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000639201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000639201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037288at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF966">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXII) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="139" mass="15617" checksum="392F808B058386DC" modified="2016-01-20" version="1">MRVRMVPGCLAEGVKITPVVINYRGVAETTNIVEGRFINASDITILVFRGTVISQEIRGELVRLGVRIHDVWRNKGSVAQRYLPSHVRRNQAPVIPVWVPLTNQLKSPHSTCVCPRFVNDQSYLFISQAYEASVSTDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X151</accession>
    <name>A0A0R3X151_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CYTOSOL_AP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TTAC_LOCUS6885</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020329">
        <property type="protein sequence ID" value="VDM31165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X151"/>
    <dbReference type="STRING" id="6205.A0A0R3X151"/>
    <dbReference type="WBParaSite" id="TTAC_0000690001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000690001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000690001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VDM31165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000690001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="542" mass="58706" checksum="D001F5823D02BFDE" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X188</accession>
    <name>A0A0R3X188_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS6933</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020333">
        <property type="protein sequence ID" value="VDM31221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X188"/>
    <dbReference type="STRING" id="6205.A0A0R3X188"/>
    <dbReference type="WBParaSite" id="TTAC_0000694801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000694801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000694801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22674">
        <property type="entry name" value="FHA_PPP1R8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM31221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000694801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42014" checksum="EC9B24B39AA8F191" modified="2016-01-20" version="1">MGGVSGEPLVNNFKIPSWAAKPPPGVHLDVMKDGKLIQKLMMDDKSCYFFGRNRQLCDFAIDHQSCSRIHAALVWHKNLNRAFLIDLGSVHGTFIGRIKLEPERPQQVPIDSEIHFGASTRVYIIRERPNPIINSSTAEADRLIKEAADATGNANKLPQSEVELDNLTQFNTAHNRRIAVSDMQPPTVSVVQRGRRNSLNQRLSVHFSDIEEVINPEDVDPSIGRFRNLVQETFIPNKGAHKHEGADIGIAAPRSNPTPSRPSINEPVANQSTRLATTVSNPSFTLAAKLGLPMPNLAPEIDSVEPQTTPLMHRLPTTGATRLSAEDIFGGPLPGPKDEAATGGKRPANTSSGGEEAENAAPKKKKYAKEAWPGKRPGFLVGPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X1D8</accession>
    <name>A0A0R3X1D8_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TTAC_LOCUS6997</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01020337">
        <property type="protein sequence ID" value="VDM31297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X1D8"/>
    <dbReference type="STRING" id="6205.A0A0R3X1D8"/>
    <dbReference type="WBParaSite" id="TTAC_0000701201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000701201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000701201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VDM31297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
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            <taxon>Metazoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020411">
        <property type="protein sequence ID" value="VDM32307.1"/>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
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            <begin position="412"/>
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            <begin position="1"/>
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            <begin position="12"/>
            <end position="33"/>
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            <begin position="142"/>
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            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="452"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="585"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="TTAC_0000785701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="690" mass="73398" checksum="A8EDA77D2A46AF29" modified="2016-01-20" version="1"> </sequence>
</entry>
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    <accession>A0A0R3X3H7</accession>
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        <submittedName>
            <fullName evidence="4">HYPK_UBA domain-containing protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">TTAC_LOCUS7889</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM32360.1"/>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="15"/>
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        <location>
            <begin position="74"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="221"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM32360.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000790401-mRNA-1"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TTAC_LOCUS8019</name>
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        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
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    </reference>
    <reference evidence="1 2" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM32504.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="TTAC_0000803401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000803401"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="VDM32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000803401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11212" checksum="06C2930E20821CFA" modified="2016-01-20" version="1">MRCSAVKNAVTLPLHLPHACRLAEESPLNFVSTVTAAAFVNAAAAAATVVPLRSHQPASGLAGACTCAGASAYDMRPDPTDESDRSERATGYTCLYICYYSAASNNW</sequence>
</entry>
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    <accession>A0A0R3X3U4</accession>
    <name>A0A0R3X3U4_HYDTA</name>
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        <submittedName>
            <fullName evidence="4">Usp domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TTAC_LOCUS8024</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2017-02" db="UniProtKB">
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    </reference>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR46989:SF3">
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    </dbReference>
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        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000803901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17968" checksum="67E690DC32DE6F13" modified="2016-01-20" version="1">MAEKGRKIGIPVDGSDNSKKAVHWYLENVADENDYVFFIHVQELLDLPLLHIKSGLNIPSDQWMKAITERNRLDEEISTEVIGLCRAKKIACDYITASDKRPGDGIVSMVGDLGIQLIIMGSRGLSTIRRTILGSVSDYVLHHSQVPVCIVPAEYTPASSTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4I9</accession>
    <name>A0A0R3X4I9_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-related protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS8314</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
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            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020483">
        <property type="protein sequence ID" value="VDM32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4I9"/>
    <dbReference type="STRING" id="6205.A0A0R3X4I9"/>
    <dbReference type="WBParaSite" id="TTAC_0000832901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000832901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000832901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000832901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45713" checksum="999BAD8981481359" modified="2016-01-20" version="1">MTVYDSIIGEKTPIIFDLGTAYIKCGFAGEACPRFILPSLFVKMDFSTTNLYDSLKELFYRLCYRYLLVNPKERRVVMVESIMTPTNFRQTIADLLFRHFEVPSILFAPAHLVALFTLGISTGLVLDCGYSEALVLPVCEGFTLLSTWHSAHLGSRHIHKRLEGLIREHAFVEDDGAERQKLSEVPDICVDGHAMLEDILMRACFISPANRAASWRKWMEESEKSEESCSIQPPPYATESFTCPLEGCGEGTRLVHIPSWLRESATEILFTADDADGVTITTLFLDCLLMCPIDCRMSLAQNVVCIGGTTMLPGFMERLNEELQKALELPHYASLAALKQHIKFHNPPAKANYTAWLGGAIFGALECLPGRSLLRDAYLKDPKLPDWNDIPDTTVPSAHPDLEPKYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4M1</accession>
    <name>A0A0R3X4M1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS8352</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020488">
        <property type="protein sequence ID" value="VDM32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4M1"/>
    <dbReference type="STRING" id="6205.A0A0R3X4M1"/>
    <dbReference type="WBParaSite" id="TTAC_0000836701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000836701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000836701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="43"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000836701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39819" checksum="E11DF97F3CBA01AA" modified="2016-06-08" version="2">MMIALSSLFNSRSPLGEADGDSETHCHSGPNEGGVDKIARRKLLIASALCLIFMIGEATGGALAGSLAIMTDAAHLLTDFASFLISLFAIFLSGRPATRMMSFGWYRAEVVGALVSVLMIWLVTGILVYLAVMRVIHQHYEIDGMVMLITSAVGVAVNMVMAATLHQHGHGHGGESHGHSHDSGSHTHSHGFFSKMKKKISSMNLSRSDDIKISKDSTGDASTAICEGGEFQQGLHKPYTTDHPHDHHSHKHLAKEGTTDSEHGEENINVRAAFIHVIGDLLQSLGVMIAAFVIYFRDAMNILMEGVPKGLNFAEVRSSLQAIPGIVEVHNLRMWSLTMNKTAVSVHLATGKLFNTIVFQNPLSFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X4P4</accession>
    <name>A0A0R3X4P4_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ENTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8377</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020493">
        <property type="protein sequence ID" value="VDM32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X4P4"/>
    <dbReference type="STRING" id="6205.A0A0R3X4P4"/>
    <dbReference type="WBParaSite" id="TTAC_0000839201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000839201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000839201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000839201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="578" mass="63836" checksum="02CCC85FE1BFDC4B" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5C9</accession>
    <name>A0A0R3X5C9_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TTAC_LOCUS8650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020556">
        <property type="protein sequence ID" value="VDM33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5C9"/>
    <dbReference type="STRING" id="6205.A0A0R3X5C9"/>
    <dbReference type="WBParaSite" id="TTAC_0000866501-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000866501-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000866501"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901858">
        <property type="term" value="P:regulation of mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VDM33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000866501-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22981" checksum="9D2E13282B8B8E2C" modified="2016-01-20" version="1">MSSLVKLYHGYSNLLVKYPVRTQAISTAIIMGSGDIIAQKLVEKRKWEPSRTIKFGAIGLFTIGPLLNFWYAFLDRIYKGQSVVRTVKMVATDQIVMAPILCSSIIGLAAFTRNWSVEEAKQKLSTSFCSALKKNYMVVALIGIGDDGLVAIILVSEAVNVLKQKYYAILTFHLLFSSRSGLQRSSLTLHSFQFTSGNHHLLLTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X5V2</accession>
    <name>A0A0R3X5V2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UNC80 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS8852</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020608">
        <property type="protein sequence ID" value="VDM33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X5V2"/>
    <dbReference type="STRING" id="6205.A0A0R3X5V2"/>
    <dbReference type="WBParaSite" id="TTAC_0000886701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000886701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000886701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000886701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49886" checksum="E6719D34754C4DA4" modified="2016-01-20" version="1">MIRQRLKSTPPMDTKGRGKTQPVICSQRPPLRFDQAETKLLYTLQWLLLDAASECADNDPNFKINSQRERAYLHDLASLQLFIYLFAPVLERLKCEDFDTLKLESGLRLWAPLILHRQPYEGSFPVPVKIPLRQYDEELNVNPLRSYVDQFGPLPPVFQRPGEELGEENEFGGLETASRASRLVPHSIAPFYPTSPNLRIPNAESSDEDSAWYDRHSVPINASAMKHSHNRPVVPMARLNDICPVSLKDTDSEESESNCSESFTAGRSYLEQTLEEQIESLTQTVLKEAMATDTVLASHCDLAVMRCLFSPEWSESGAVWALRYMERRLTLLRHDRRRERVEASAHLRFQRLRATLPEACFAAADAVTGQAVDLRVLRSLSMPQLTPQYQRPSYEASSVTAMPSSQRNITTGPSSVVTTTNDIVDDGNDDERYSAEGKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X649</accession>
    <name>A0A0R3X649_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS8954</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020635">
        <property type="protein sequence ID" value="VDM33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X649"/>
    <dbReference type="STRING" id="6205.A0A0R3X649"/>
    <dbReference type="WBParaSite" id="TTAC_0000896901-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000896901-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000896901"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="104"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000896901-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26945" checksum="F5DEDC4654EC5910" modified="2016-01-20" version="1">MEIPVRRGGRSRDRQLAVRHSSGGRDTSRERDFPICPFTDLNRQFETMERQLADFKPFDMFPFSGSSTGPWFARINNEMRRVHSEMMDFMRDSGMQPNFDDFWHFPSMADCFTKDENGQTWFRTKFDLHSFNPEDIEIKVENQTLSVHAKHTQRGRNSSSGQYFCRAMLLPDGVLTEELKSKLDKNGILTVEAPAPGVEVERLSSSRSTRIPIEENSRRRRLYDRSVGMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X716</accession>
    <name>A0A0R3X716_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RF_PROK_I domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS9312</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020757">
        <property type="protein sequence ID" value="VDM34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X716"/>
    <dbReference type="STRING" id="6205.A0A0R3X716"/>
    <dbReference type="WBParaSite" id="TTAC_0000932701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000932701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000932701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VDM34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000932701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35181" checksum="9F6E3009478490C5" modified="2016-01-20" version="1">MQLNAPAADSWGSIYEAYTCYRGWRFASIANAGARKSAVGADSPIHHVEVRVESSSPIDPVHPYLQWEAGVHRVQRVPLTSKLNKIHTGTVAVIIAPSYRRGSQLLATSLRSMLPLSAGICSHIVGTASSYITTVEVELDPEDLEWEVFRASGAGGQHVNKTESAVRVRHRPTGHVAACQADRSQHANRGKALQLLRAKLANEVARRQVETEMVEKRSQIGSLARSDRIRTYNYQQDRITDHRLGRSWSGLATVMRQGLPVVNETAFALDIAYKLAALASLDKPYFFMLIYCYLIHKRILFPDWSTALHSTLDTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7I2</accession>
    <name>A0A0R3X7I2_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="1 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS9492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020849">
        <property type="protein sequence ID" value="VDM34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7I2"/>
    <dbReference type="WBParaSite" id="TTAC_0000950701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000950701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000950701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000950701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15322" checksum="4BAB5C75FEF9A1F4" modified="2016-01-20" version="1">MSQSNRSTDWPVGKDEGEVANCSYSAPTKVVKVRQRPLQLSEKLLEMLNEHFHTFGRPRFGKRYYSNDDWMYFLPPQEVNDVLWLEDFEPLHRPQLLEPVAPEFIVDTNDDSLPQAQRGRLLRSLRLDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X7N5</accession>
    <name>A0A0R3X7N5_HYDTA</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Phospholipase ABHD3</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Abhydrolase domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">TTAC_LOCUS9545</name>
    </gene>
    <organism evidence="36">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34 35" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54456"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54457"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54404"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:131738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
            <dbReference type="ChEBI" id="CHEBI:138269"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 5-oxopentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40483"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16120"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77890"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40484"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 9-oxononanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61042"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77812"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = glutarate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77756"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:78207"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:75220"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = hexanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138212"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = nonanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54472"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32361"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54473"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138213"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = pentanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31011"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54400"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76085"/>
            <dbReference type="ChEBI" id="CHEBI:86162"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:54401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:86102"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="UYWX01020883">
        <property type="protein sequence ID" value="VDM34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X7N5"/>
    <dbReference type="STRING" id="6205.A0A0R3X7N5"/>
    <dbReference type="WBParaSite" id="TTAC_0000956001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000956001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000956001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000079">
        <property type="entry name" value="Abhydrolase domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="33">
        <location>
            <begin position="69"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00059841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00082158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="VDM34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000956001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="634" mass="70795" checksum="AE41628F58958B7C" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X827</accession>
    <name>A0A0R3X827_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Beta-1,4-galactosyltransferase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TTAC_LOCUS9687</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01020982">
        <property type="protein sequence ID" value="VDM34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X827"/>
    <dbReference type="STRING" id="6205.A0A0R3X827"/>
    <dbReference type="WBParaSite" id="TTAC_0000970201-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000970201-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000970201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="11">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VDM34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000970201-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30931" checksum="31F85BE77C74B0C4" modified="2016-01-20" version="1">MSFFVCTRLSFFQKYCLLILATSILILTAWSIIQPDCKSPSKISVNHTLGVIVPFRDRFTNLLSFLPHMHRYLKRKGIPHTFYIVNQADDYRFNRGSLLNVGVKESEVMESRHFESSKSRRTRPQPACSMVALHDVDLLPIDDALRYEHFGRHPYHLIPYWMHPLYYAYSSYIGGAIIISRESYKLINGFSNRFWGWGQEDDEFGLRMREANLVATHLRDHTSGLNTTRYTVLSRISAEISNVNVWILNVQLHCDTLTTPHCRQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3X923</accession>
    <name>A0A0R3X923_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS10033</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="UYWX01021255">
        <property type="protein sequence ID" value="VDM35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3X923"/>
    <dbReference type="STRING" id="6205.A0A0R3X923"/>
    <dbReference type="WBParaSite" id="TTAC_0001004801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001004801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001004801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF54">
        <property type="entry name" value="MAD-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VDM35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001004801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39769" checksum="22437E6AF78FE171" modified="2016-01-20" version="1">MTESPLKDGLLLLLQAAQKIDRESKSTCHHPERWDARTGSSRHFYDDGPAHFPSPYSSSSIHRRNAPSTRCTHNELEKSRRAHLRTCMDALKELLVFDTEAPRITTLTVLRKATSTIQQLQQRNEYLEACEDGEKQRFSQLMKRRQALRKKIEAKRNRTLKIQNWRERNRNYSECSVLTTSSEDSEMGYSSRHMPSNVYSILPLPHHQQQQQLSANDNHRYASPYGTTAGVVATTANSTATTAAATVSMMNSDSATTVTTPATNTSAAAVTYAASQAHPNPSYHPKMVSHSPHLSTGAQGMSPTDAYDASSSDSGFEEVITATSAADEQQTLKMVPSVVSNTEEVVYTAYQSGDGFKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA50</accession>
    <name>A0A0R3XA50_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10410</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01021666">
        <property type="protein sequence ID" value="VDM35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA50"/>
    <dbReference type="STRING" id="6205.A0A0R3XA50"/>
    <dbReference type="WBParaSite" id="TTAC_0001042701-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001042701-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001042701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433755at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19856">
        <property type="entry name" value="DSRM_Kanadaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001042701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="746" mass="83421" checksum="DE922B6C26A9E030" modified="2016-01-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XA83</accession>
    <name>A0A0R3XA83_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat domain phosphoinositide-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS10443</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01021705">
        <property type="protein sequence ID" value="VDM35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XA83"/>
    <dbReference type="STRING" id="6205.A0A0R3XA83"/>
    <dbReference type="WBParaSite" id="TTAC_0001046001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001046001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001046001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001046001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24249" checksum="FE3E4AD920EB7C62" modified="2016-01-20" version="1">MAGGVSSTMLEDLPILFIDFNQDFTTLCIGTRSGYSLLSTDNHEILETYSVNGESMCLVSRLFTSNLVVLVSLRDTRKLLIFHSRRDSLICDYRYTNTILSVKMNRQRLVVCLENEIFIHNIRDMSVLHRIEDTPSNRNGVIAFSTCPDKCLLAYPGSSRVGTVYIFDALTFTKVLLFNLSVNIHVTSVCEIGGIPVTGLDFFGREKSERKFVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBB6</accession>
    <name>A0A0R3XBB6_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS10826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01022315">
        <property type="protein sequence ID" value="VDM35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBB6"/>
    <dbReference type="WBParaSite" id="TTAC_0001084301-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001084301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001084301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001084301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12620" checksum="811C91755899938C" modified="2016-01-20" version="1">MADRLPTTLPLQMPIDCITVGSLVHAQLTTYKVGGGEEGEIFPPPPTPPNTVQRSVRHYERTVPLLPPLPPPPPPPRLVTRHSNFTSPPPTPVRGDTMCQAVMEGEGPDRTRQSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XBV7</accession>
    <name>A0A0R3XBV7_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2'-phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TTAC_LOCUS11017</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01022744">
        <property type="protein sequence ID" value="VDM35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XBV7"/>
    <dbReference type="STRING" id="6205.A0A0R3XBV7"/>
    <dbReference type="WBParaSite" id="TTAC_0001103401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001103401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001103401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VDM35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001103401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16700" checksum="B8EA58339A5EB4A7" modified="2016-01-20" version="1">MIASFAFKGGYLYVDEILKSRQFIGVTISKLEEIVRCDAKGRYELNQSPRSGRLRIRAVQGHSAKVDGLDLTPIVRGAVKTAVHGTYLRFWPSISKQGLSRMSRSHIHFATGDPGDESVISDMRSSAQVLIYIDIDAAIRGKVKVWNLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XC71</accession>
    <name>A0A0R3XC71_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TTAC_LOCUS11131</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01023032">
        <property type="protein sequence ID" value="VDM36111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XC71"/>
    <dbReference type="STRING" id="6205.A0A0R3XC71"/>
    <dbReference type="WBParaSite" id="TTAC_0001114801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001114801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001114801"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048495">
        <property type="term" value="F:Roundabout binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050919">
        <property type="term" value="P:negative chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF4">
        <property type="entry name" value="PROTEIN SLIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VDM36111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001114801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22008" checksum="06E77EDD11BD49B6" modified="2016-01-20" version="1">MPCDPPHNQCQHGTCETLYEVFETRVQNQTKTASLISSFRCICDPGWTGVVCNHPIDVCLRHRCQNGAQCVAKGEHYECRCPEGYEGVFCEEPINQALSNQSTKKRDTQNDLEEHCLLLGCTGTAETNGTCSGRCIQAGCFNQEQLDACKAWIDCLEATKTEFSVGQPTCVERYRDGVCDHACSISSCFYDGFDCTSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XD77</accession>
    <name>A0A0R3XD77_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ERAP1_C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS11487</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="UYWX01024420">
        <property type="protein sequence ID" value="VDM36660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6205.A0A0R3XD77"/>
    <dbReference type="WBParaSite" id="TTAC_0001150401-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001150401-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001150401"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM36660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001150401-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34150" checksum="4519D1D1D1FDF269" modified="2016-01-20" version="1">MAVPPKVGVFRDIHETPVYWRIPINVCLVDDSSKLLLRKVTNIPSSSNASHHGDKVQSKVEADAECKEILYPIPDFIKDPQXXXXIPINVCLVDDSSKLLLRKVSFAEESKEICGLNRLYLELALPVYEKIGFEPKSGESNNDRELRPIIISILGRIGHGDVIAKAESAFERHYGAVTCVPVGEAVVDQSKLIGADLRGAVYCMCMRNGGEEEYKKLLELHDRATLNDERVRVLGSLGATTNGDLMQRLFELTFTEYVRKQDRARTLLGVTGTPGGRRALWNLVRGRIATLSDDLGTSHLLARVIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0R3XDE1</accession>
    <name>A0A0R3XDE1_HYDTA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TTAC_LOCUS11551</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01024936">
        <property type="protein sequence ID" value="VDM36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0R3XDE1"/>
    <dbReference type="WBParaSite" id="TTAC_0001156801-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0001156801-mRNA-1"/>
        <property type="gene ID" value="TTAC_0001156801"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VDM36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0001156801-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9671" checksum="DE7D2E10B7FB68B1" modified="2016-01-20" version="1">MRHRTPIIEARSQGHHDVVQYLLRAEHTDAASKVDESGHTRVPATTTTTTATATASLMARNAQPFNPVCTTRYCYKCVPLRPLPHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDK4</accession>
    <name>A0A158RDK4_HYDTA</name>
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        <submittedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TTAC_LOCUS791</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="VDM16996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158RDK4"/>
    <dbReference type="WBParaSite" id="TTAC_0000079001-mRNA-1">
        <property type="protein sequence ID" value="TTAC_0000079001-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000079001"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6269290at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VDM16996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000079001-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="644" mass="69425" checksum="4A42B428B78098A8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158RDR0</accession>
    <name>A0A158RDR0_HYDTA</name>
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        <submittedName>
            <fullName evidence="11">Zinc finger C2HC domain-containing protein 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TTAC_LOCUS1354</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TTAC_0000136701"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255185at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF25">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1A"/>
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    </dbReference>
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        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
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        </location>
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            <end position="389"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VDM17859.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000136701-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59297" checksum="57F464E677AC9292" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TTAC_LOCUS6818</name>
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    <organism evidence="4">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
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            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="TTAC_0000683301-mRNA-1"/>
        <property type="gene ID" value="TTAC_0000683301"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VDM31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="TTAC_0000683301-mRNA-1"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142189" checksum="A1DDB8A76404DF10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A158REB2</accession>
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    <protein>
        <submittedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TTAC_LOCUS6987</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Hydatigena taeniaeformis</name>
        <name type="common">Feline tapeworm</name>
        <name type="synonym">Taenia taeniaeformis</name>
        <dbReference type="NCBI Taxonomy" id="6205"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Cestoda</taxon>
            <taxon>Eucestoda</taxon>
            <taxon>Cyclophyllidea</taxon>
            <taxon>Taeniidae</taxon>
            <taxon>Hydatigera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-04" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2018-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="UYWX01020336">
        <property type="protein sequence ID" value="VDM31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A158REB2"/>
    <dbReference type="STRING" id="6205.A0A158REB2"/>
    <dbReference type="WBParaSite" id="TTAC_0000700201-mRNA-1">
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        <property type="gene ID" value="TTAC_0000700201"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000274429">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KELCH PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BACK"/>
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    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="